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Journal articles on the topic 'FreeSurfer (Software)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Muschelli, John, Elizabeth Sweeney, and Ciprian M. Crainiceanu. "freesurfer: Connecting the Freesurfer software with R." F1000Research 7 (May 16, 2018): 599. http://dx.doi.org/10.12688/f1000research.14361.1.

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We present the packagefreesurfer, a set of R functions that interface with Freesurfer, a commonly-used open-source software package for processing and analyzing structural neuroimaging data, specifically T1-weighted images. Thefreesurferpackage performs operations on nifti image objects in R using command-line functions from Freesurfer, and returns R objects back to the user. freesurferallows users to process neuroanatomical images and provides functionality to convert and read the output of the Freesurfer pipelines more easily, including brain images, brain surfaces, and Freesurfer output tab

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Aljondi, Rowa, Cassandra Szoeke, Chris Steward, Elaine Lui, Salem Alghamdi, and Patricia Desmond. "The impact of hippocampal segmentation methods on correlations with clinical data." Acta Radiologica 61, no. 7 (2019): 953–63. http://dx.doi.org/10.1177/0284185119885120.

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Background In vivo measurement of hippocampal volume with magnetic resonance imaging (MRI) has become an important element in neuroimaging research. However, hippocampal volumetric findings and their relationship with cardiovascular risk factors and memory performance are still controversial and inconsistent for non-demented adults. Purpose To compare total and regional hippocampal volumes from manual tracing and automated Freesurfer segmentation methods and their relationship with mid-life clinical data and late-life verbal episodic memory performance in older women. Material and Methods This

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Cardinale, Francesco, Giuseppa Chinnici, Manuela Bramerio, et al. "Validation of FreeSurfer-Estimated Brain Cortical Thickness: Comparison with Histologic Measurements." Neuroinformatics 12, no. 4 (2014): 535–42. http://dx.doi.org/10.1007/s12021-014-9229-2.

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Wittens, Mandy Melissa Jane, Diana Maria Sima, Ruben Houbrechts, et al. "Diagnostic Performance of Automated MRI Volumetry by icobrain dm for Alzheimer’s Disease in a Clinical Setting: A REMEMBER Study." Journal of Alzheimer's Disease 83, no. 2 (2021): 623–39. http://dx.doi.org/10.3233/jad-210450.

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Background: Magnetic resonance imaging (MRI) has become important in the diagnostic work-up of neurodegenerative diseases. icobrain dm, a CE-labeled and FDA-cleared automated brain volumetry software, has shown potential in differentiating cognitively healthy controls (HC) from Alzheimer’s disease (AD) dementia (ADD) patients in selected research cohorts. Objective: This study examines the diagnostic value of icobrain dm for AD in routine clinical practice, including a comparison to the widely used FreeSurfer software, and investigates if combined brain volumes contribute to establish an AD di

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Lee, Jungbin, Ji Young Lee, Se Won Oh, et al. "Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer." Journal of Clinical Neurology 17, no. 2 (2021): 307. http://dx.doi.org/10.3988/jcn.2021.17.2.307.

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Bruurmijn, Mark L. C. M., Wouter Schellekens, Mathijs A. H. Raemaekers, and Nick F. Ramsey. "A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex." Neuroinformatics 18, no. 2 (2019): 283–93. http://dx.doi.org/10.1007/s12021-019-09441-y.

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AbstractFor some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, or if one needs to compare the left and right hemisphere in the same subject. Here we propose a new standard representation, building upon existing normalization methods: Cgrid (Cartesian geometric representation with isometric dimensions). Cgrid is based on imposing a Cartesian grid over a cortical region of interest that is bounded by anatomical (atlas-based) lan

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Sörös, Peter, Louise Wölk, Carsten Bantel, Anja Bräuer, Frank Klawonn, and Karsten Witt. "Replicability, Repeatability, and Long-term Reproducibility of Cerebellar Morphometry." Cerebellum 20, no. 3 (2021): 439–53. http://dx.doi.org/10.1007/s12311-020-01227-2.

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AbstractTo identify robust and reproducible methods of cerebellar morphometry that can be used in future large-scale structural MRI studies, we investigated the replicability, repeatability, and long-term reproducibility of three fully automated software tools: FreeSurfer, CEREbellum Segmentation (CERES), and automatic cerebellum anatomical parcellation using U-Net with locally constrained optimization (ACAPULCO). Replicability was defined as computational replicability, determined by comparing two analyses of the same high-resolution MRI data set performed with identical analysis software and

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Enyagina, Irina M., Andrey N. Polyakov, Alexey A. Poyda, and Vadim L. Ushakov. "System for Automatic Processing and Analysis of MRI/fMRI Data on the Kurchatov Institute Supercomputer." EPJ Web of Conferences 226 (2020): 03006. http://dx.doi.org/10.1051/epjconf/202022603006.

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This paper presents the Computer Model of the System for Automatic Processing and Analysis of MRI/fMRI tomography data, obtained at the Kurchatov Institute Resource Center “Cognimed”. The System is based on the “Digital Lab” IT-Platform, involving the Kurchatov Institute Supercomputer Cluster HPC4, which allows speeding up the processing of data for groups (2–350 subjects) by parallelization of computations on the supercomputer nodes (1 subject – 1 node). The proposed System allows scientists to remotely use the installed on the supercomputer specialized software to process and analyze MRI/fMR

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Palumbo, L., P. Bosco, M. E. Fantacci, et al. "Evaluation of the intra- and inter-method agreement of brain MRI segmentation software packages: A comparison between SPM12 and FreeSurfer v6.0." Physica Medica 64 (August 2019): 261–72. http://dx.doi.org/10.1016/j.ejmp.2019.07.016.

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Leon-Llamas, Juan Luis, Santos Villafaina, Alvaro Murillo-Garcia, Francisco Javier Dominguez-Muñoz, and Narcis Gusi. "Effects of 24-Week Exergame Intervention on the Gray Matter Volume of Different Brain Structures in Women with Fibromyalgia: A Single-Blind, Randomized Controlled Trial." Journal of Clinical Medicine 9, no. 8 (2020): 2436. http://dx.doi.org/10.3390/jcm9082436.

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Background: Exergame-induced changes in the volume of brain gray matter have not been studied in fibromyalgia (FM). This study evaluates the effects of a 24-week exergame-based intervention on the gray matter volume of different brain structures in patients with FM through magnetic resonance imaging (MRI). Methods: A total of 25 FM patients completed 24 weeks of intervention program, and another 25 FM patients did not receive any intervention. T1-weighted MRI was used to assess brain volume, and FreeSurfer software was used to segment the brain regions. Results: No significant effects on gray

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Leon-Llamas, Juan Luis, Santos Villafaina, Alvaro Murillo-Garcia, and Narcis Gusi. "Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1549. http://dx.doi.org/10.3390/ijerph18041549.

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Patients with fibromyalgia (FM) show widespread pain associated with other symptoms such as cognitive problems, depression, and anxiety among others associated with alterations in the central nervous system. The hippocampal subfields had differences in function, histology, and connectivity with other brain regions, and are altered in different diseases. This study evaluates the volumetric differences between patients with FM compared with a healthy control group. A total of 49 women with, and 43 healthy women completed this study. T1-weighted MRI was used to assess brain volume, and FreeSurfer

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12

Dieckmeyer, Michael, Abhijit Guha Roy, Jyotirmay Senapati, et al. "Effect of MRI acquisition acceleration via compressed sensing and parallel imaging on brain volumetry." Magnetic Resonance Materials in Physics, Biology and Medicine 34, no. 4 (2021): 487–97. http://dx.doi.org/10.1007/s10334-020-00906-9.

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Abstract Objectives To investigate the effect of compressed SENSE (CS), an acceleration technique combining parallel imaging and compressed sensing, on potential bias and precision of brain volumetry and evaluate it in the context of normative brain volumetry. Materials and methods In total, 171 scans from scan-rescan experiments on three healthy subjects were analyzed. Each subject received 3D-T1-weighted brain MRI scans at increasing degrees of acceleration (CS-factor = 1/4/8/12/16/20/32). Single-scan acquisition times ranged from 00:41 min (CS-factor = 32) to 21:52 min (CS-factor = 1). Brai

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Mullins, D., E. Daly, A. Simmons, et al. "Comparison of Brain Morphology in Alzheimer’s Dementia in the General Population and Demented Subjects with Down’s Syndrome." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70928-9.

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Aim:To compare Magnetic Resonance Imaging (MRI) findings in Alzheimer's dementia (AD) in the general population with Down's syndrome dementia.Background review: AD is characterised by cognitive dysfunction interfering with activities of daily living. Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia. People with Down's syndrome have an increased risk of developing AD. AD pathology initially appears in the entorhinal cortex, followed by the hippocampus and later in the temporal lobes. These areas are critical for memory functioning.Method:Volumetric anal

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Prakhova, L. N., Ye P. Magonov, A. G. Ilves, et al. "EFFECT OF NEURODEGENERATIVE CHANGES IN THE BRAIN ON THE FORMATION OF THE DISEASE CLINICAL PICTURE IN PATIENTS WITH MULTIPLE SCLEROSIS." Bulletin of Siberian Medicine 12, no. 3 (2013): 52–60. http://dx.doi.org/10.20538/1682-0363-2013-3-52-60.

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The aim of the study was to determine the relationship of global and regional cerebral atrophy and volume of demyelination lesions in the brain with a clinical picture in patients with multiple sclerosis (MS). The study involved 55 patients with MS. Control group included 22 healthy volunteers. Patients were divided into groups according to the severity of disability, the type and duration of disease. Assessment of general and regional atrophy was performed by post-process volumetric segmentation of MRI data, which was acquired at 3T Philips Achieva scanner. The post-processing was done with t

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Kambe, Taiki, Asako Yasuda, Setsuo Kinoshita, Masahiro Shigeta, and Toru Kinoshita. "Severity of Depressive Symptoms and Volume of Superior Temporal Gyrus in People Who Visit a Memory Clinic Unaccompanied." Dementia and Geriatric Cognitive Disorders Extra 8, no. 2 (2018): 207–13. http://dx.doi.org/10.1159/000489008.

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Background/Aims: Depression and cognitive decline are reported to be interrelated. Depression of older adults with memory complaints who seek medical help have not been well documented. This study was carried out to test the hypothesis that a relatively high level of depressive symptoms associated with brain structure is characteristic of people who visited a memory clinic unaccompanied (UA). Method: We retrospectively compared Center for Epidemiologic Studies Depression Scale (CES-D, for evaluation of depressive symptoms) scores of UA subjects (n = 21) with those of people who were accompanie

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Cheng, Bastian, Robert Schulz, Marlene Bönstrup, et al. "Structural Plasticity of Remote Cortical Brain Regions is Determined by Connectivity to the Primary Lesion in Subcortical Stroke." Journal of Cerebral Blood Flow & Metabolism 35, no. 9 (2015): 1507–14. http://dx.doi.org/10.1038/jcbfm.2015.74.

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Cortical atrophy as demonstrated by measurement of cortical thickness (CT) is a hallmark of various neurodegenerative diseases. In the wake of an acute ischemic stroke, brain architecture undergoes dynamic changes that can be tracked by structural and functional magnetic resonance imaging studies as soon as 3 months after stroke. In this study, we measured changes of CT in cortical areas connected to subcortical stroke lesions in 12 patients with upper extremity paresis combining white-matter tractography and semi-automatic measurement of CT using the Freesurfer software. Three months after st

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Iskhakova, E. V., A. G. Trufanov, A. Yu Efimtsev, A. A. Yurin, A. S. Lepekhina, and V. A. Fokin. "Magnetic resonance morphometry of the brain in the advanced stages of Parkinson's disease and vascular parkinsonism." Diagnostic radiology and radiotherapy 11, no. 4 (2021): 16–22. http://dx.doi.org/10.22328/2079-5343-2020-11-4-16-22.

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Introduction. MR-morphometry is a method of image processing independent of the researcher, which allows you to get the results of measuring the volume of the brain structures and the thickness of various areas of the cortex and helps in the differential diagnosis in assessing the results of MRI. Our study used MR-morphometry to identify structural markers in the differential diagnosis of vascular parkinsonism in the examination of patients with Parkinson's symptoms. Purpose of research. Visualization of the distribution of atrophic changes in brain structures in vascular parkinsonism and in t

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Bae, Seongryu, Kenji Harada, Sangyoon Lee, et al. "The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial." Journal of Clinical Medicine 9, no. 5 (2020): 1312. http://dx.doi.org/10.3390/jcm9051312.

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The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining physical exercise and cognitive training in older adults with cognitive decline. This study involved a secondary analysis of neuroimaging data from a randomized controlled trial with 280 older adults having cognitive decline who were randomly assigned to either a multicomponent exercise group (n = 140) that attended weekly 90-minute exercise and cognitive training sessions or a health education control group (n = 140). The cortical thickness and cognitive performance

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Schultz, C. C., K. Koch, G. Wagner, et al. "FC07-02 - Increased parahippocampal and lingual gyrification in first-episode schizophrenia." European Psychiatry 26, S2 (2011): 1847. http://dx.doi.org/10.1016/s0924-9338(11)73551-9.

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IntroductionSurface based MRI methods are a promising approach for the identification of cerebral shape alterations in schizophrenia [1]. In particular, investigating gyrification might offer important evidence for disturbed neurodevelopmental mechanisms in schizophrenia.ObjectiveThe present study is the first to compare on a vertex - wise basis mean curvature as a sensitive parameter for the identification of local gyrification changes in first episode schizophrenia.Methods54 patients with first-episode schizophrenia and 54 healthy control subjects underwent high-resolution T1-weighted MRI sc

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Liang, Xue, Zhenyu Yin, Renyuan Liu та ін. "The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects". Neurodegenerative Diseases 18, № 5-6 (2018): 270–80. http://dx.doi.org/10.1159/000495754.

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Purpose: (1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer’s disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ε4 gene and cognitive status. Methods: The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive

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Petzold, Axel, Martijn D. Steenwijk, Judith M. Eikelenboom, Mike P. Wattjes, and Bernard MJ Uitdehaag. "Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study." Multiple Sclerosis Journal 22, no. 9 (2016): 1154–62. http://dx.doi.org/10.1177/1352458516645206.

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Background: Body fluid and structural imaging biomarkers give information on neurodegeneration. The relationship over time is not known in multiple sclerosis. Objective: To investigate the temporal relationship of elevated cerebrospinal fluid (CSF) neurofilament (Nf) protein levels, a biomarker for axonal loss, with magnetic resonance imaging (MRI) atrophy measures. Methods: In patients with multiple sclerosis, CSF Nf heavy chain (NfH) phosphoform levels were quantified at baseline and dichotomised into ‘normal’ and ‘high’. Atrophy was assessed by MRI at baseline and 15-year follow-up using SI

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Batista, Sonia, Otília C. d’Almeida, Ana Afonso, et al. "Impairment of social cognition in multiple sclerosis: Amygdala atrophy is the main predictor." Multiple Sclerosis Journal 23, no. 10 (2016): 1358–66. http://dx.doi.org/10.1177/1352458516680750.

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Background: Patients with multiple sclerosis (MS) frequently reveal social behavior disturbance. Nevertheless, little is known regarding the impact of MS on social cognition, particularly theory of mind (ToM), and its neural basis. Objectives: To explore how ToM is affected in MS and its neural correlates. Methods: Enrolled 60 consecutive MS patients and 60 healthy controls (HC) matched on age, sex, and education. Participants underwent ToM testing (Eyes Test, Videos Test) and 3 T brain magnetic resonance imaging (MRI). Using Freesurfer software, cortical and subcortical gray matter (GM) volum

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Santos, Alicia, Esther Granell, Beatriz Gómez-Ansón, et al. "Depression and Anxiety Scores Are Associated with Amygdala Volume in Cushing’s Syndrome: Preliminary Study." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/2061935.

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Introduction. Cushing’s syndrome (CS) has repeatedly been associated with hippocampal volume reductions, while little information is available on the amygdala, another structure rich in glucocorticoid receptors. The aim of the study was to analyze amygdala volume in patients with CS and its relationship with anxiety, depression, and hormone levels. Material and Methods. 39 CS patients (16 active and 23 patients in remission) and 39 healthy controls matched for age, sex, and education level completed anxiety (STAI) and depression tests (BDI-II) and underwent a 3 Tesla brain MRI and endocrine te

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Du Plessis, Stéfan, Hilmar Luckhoff, Sanja Kilian, et al. "S201. HIPPOCAMPAL SUBFIELD VOLUMES AND CHANGE IN BODY MASS OVER 12 MONTHS OF TREATMENT IN FIRST-EPISODE SCHIZOPHRENIA SPECTRUM DISORDERS." Schizophrenia Bulletin 46, Supplement_1 (2020): S114—S115. http://dx.doi.org/10.1093/schbul/sbaa031.267.

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Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size

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Osechinskiy, Sergey, and Frithjof Kruggel. "Cortical Surface Reconstruction from High-Resolution MR Brain Images." International Journal of Biomedical Imaging 2012 (2012): 1–19. http://dx.doi.org/10.1155/2012/870196.

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Reconstruction of the cerebral cortex from magnetic resonance (MR) images is an important step in quantitative analysis of the human brain structure, for example, in sulcal morphometry and in studies of cortical thickness. Existing cortical reconstruction approaches are typically optimized for standard resolution (~1 mm) data and are not directly applicable to higher resolution images. A new PDE-based method is presented for the automated cortical reconstruction that is computationally efficient and scales well with grid resolution, and thus is particularly suitable for high-resolution MR imag

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Cuesta, M. J., A. M. Sánchez-Torres, T. Cabada, et al. "Parkinsonism and basal ganglia volumes in first-episode psychosis." European Psychiatry 33, S1 (2016): S87. http://dx.doi.org/10.1016/j.eurpsy.2016.01.046.

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IntroductionParkinsonian motor signs are the most frequent of the genuine motor abnormalities present in drug-naïve patients with schizophrenia, and are also present in patients with a first-episode of psychosis (FEP).ObjectiveTo study whether there are differences in basal ganglia volumes depending on the presence of Parkinsonism in FEP.MethodsForty-six patients with a FEP were included in the study. Twenty-three controls were included to normalise patients’ brain volume data. Parkinsonism was assessed with the UKU scale. Brain volumes were obtained with MRI (1.5 Tesla Siemens Avanto). Recons

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Pastoriza, F., L. Galindo, A. Mané, et al. "Cortical and subcortical morphology deficits in cerebral gray matter in patients with schizophrenia and not affected siblings." European Psychiatry 33, S1 (2016): s249. http://dx.doi.org/10.1016/j.eurpsy.2016.01.632.

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ObjectiveExplore the basis of cortical morphometry in patients with schizophrenia and non-affected siblings by Magnetic Resonance Structural analyzing cortical thickness.MethodsTwenty-nine patients with schizophrenia treated with atypical antipsychotics and clinically stable in the last 6 months were recruited. Twenty-three not affected siblings of patients with schizophrenia and 37 healthy volunteers were recruited. Magnetic Resonance Structural was performed. FreeSurfer the brain imaging software package for analysis of Cortical Thickness is used. In the analysis of group differences in cort

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Zanghieri, Marcello, Giulia Menichetti, Alessandra Retico, Sara Calderoni, Gastone Castellani, and Daniel Remondini. "Node Centrality Measures Identify Relevant Structural MRI Features of Subjects with Autism." Brain Sciences 11, no. 4 (2021): 498. http://dx.doi.org/10.3390/brainsci11040498.

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Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions characterized by impairments in social interaction and communication and restricted patterns of behavior, interests, and activities. Although the etiopathogenesis of idiopathic ASD has not been fully elucidated, compelling evidence suggests an interaction between genetic liability and environmental factors in producing early alterations of structural and functional brain development that are detectable by magnetic resonance imaging (MRI) at the group level. This work shows the results of a network-based

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Crivelli, Lucia, Ismael-Luis Calandri, Belén Helou, et al. "La Cognición Social en la Esclerosis Múltiple Temprana: Enfoque neuropsicológico y anatómico." Journal of Applied Cognitive Neuroscience 2, no. 1 (2021): e00153735. http://dx.doi.org/10.17981/jacn.2.1.2021.03.

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Cognitive impairment and deficits in social cognition (SC) are frequent in patients with multiple sclerosis (MS). The aim of the present work is to study SC in patients with early MS and to analyze its neuroanatomical correlation. Thirty-four patients with relapsing remitting MS, with ≤ 2 years of disease progression and EDSS and ≤2, and 30 healthy control subjects matched for age, sex, and educational level were recruited. Subjects performed a comprehensive neuropsychological assessment (Rao BRB). SC was assessed using the International Affective Picture System IAPS, The Eyes in the Mind Test

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Bae, Seongryu, Sangyoon Lee, Kenji Harada, et al. "Engagement in Lifestyle Activities is Associated with Increased Alzheimer’s Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults." Journal of Clinical Medicine 9, no. 5 (2020): 1424. http://dx.doi.org/10.3390/jcm9051424.

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The aim of this study was to examine the association between lifestyle activities, including physical, cognitive, and social activities, and Alzheimer’s disease (AD) signature cortical thickness, as well as to examine the mediating role of AD signature cortical thickness in lifestyle activities and cognitive function in community-dwelling healthy older adults. Participants were 1026 older adults who met the study inclusion criteria. The physical, cognitive, and social activities of daily life were assessed using a self-reporting questionnaire. AD signature cortical thickness was determined usi

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Assunção Leme, Idaiane Batista, Ary Gadelha, João Ricardo Sato, et al. "Is there an association between cortical thickness, age of onset, and duration of illness in schizophrenia?" CNS Spectrums 18, no. 6 (2013): 315–21. http://dx.doi.org/10.1017/s1092852913000333.

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ObjectiveSeveral studies have shown cortical volume loss in frontotemporal regions in schizophrenia patients, and it is known that these reductions may be associated with disease symptoms and cognitive deficits. The aim of this study was to investigate possible cortical thickness correlations in frontotemporal regions in relation to age at onset and duration of illness.MethodsOne hundred forty-eight schizophrenia patients (97 males; age and SD 36.30 ± 10.06) and 87 (57 males; age and SD 36.48 ± 10.10) age-matched healthy subjects underwent a brain MRI scan. Cortical segmentation and surface st

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Irimia, Andrei, Jun Kim, Shania Wang, et al. "Statistical Estimation of Accelerated Biological Brain Aging After Mild Traumatic Brain Injury in Older Adults." Innovation in Aging 4, Supplement_1 (2020): 890. http://dx.doi.org/10.1093/geroni/igaa057.3282.

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Abstract Estimating biological brain age (BA) has the potential of identifying individuals at relatively high risk for accelerated neurodegeneration. This study compares the brain’s chronological age (CA) to its BA and reveals the BA rate of change after mild traumatic brain injury (mTBI) in an aging cohort. Using T1-weighted magnetic resonance imaging (MRI) volumes and cortical thickness, volume, surface area, and Gaussian curvature obtained using FreeSurfer software; we formulated a multivariate linear regression to determine the rate of BA increase associated with mTBI. 95 TBI patients (age

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Zhu, Xueling, Shaohui Liu, Weihua Liao, Lingyu Kong, Canhua Jiang, and Fulai Yuan. "Executive function deficit in betel-quid-dependent chewers: Mediating role of prefrontal cortical thickness." Journal of Psychopharmacology 32, no. 12 (2018): 1362–68. http://dx.doi.org/10.1177/0269881118806299.

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Background: Betel quid is the fourth most popular psychoactive agent worldwide. Neuroimaging studies have suggested betel-quid dependence is accompanied by abnormality in brain structure and function. However, the neural correlates of executive function deficit and prefrontal cortical thickness associated with betel-quid chewing still remain unclear. Objective: The present study aimed to examine the relationship between executive function deficit and prefrontal cortical thickness in chronic betel-quid chewers. Methods: Twenty-three betel-quid-dependent chewers and 26 healthy controls were recr

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Corrêa, Diogo G., Nicolle Zimmermann, Nina Ventura, et al. "Longitudinal evaluation of resting-state connectivity, white matter integrity and cortical thickness in stable HIV infection: Preliminary results." Neuroradiology Journal 30, no. 6 (2017): 535–45. http://dx.doi.org/10.1177/1971400917739273.

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Purpose The objectives of this study were to determine if HIV-infected patients treated with highly active antiretroviral therapy (HAART), without dementia, suffer from longitudinal gray matter (GM) volume loss, changes in white matter (WM) integrity and deterioration in functional connectivity at rest, in an average interval of 30 months. Methods Clinically stable HIV-positive patients (on HAART, CD4 + T lymphocyte > 200 cells/μl, and viral loads <50 copies/μl) were recruited. None of them had HIV-associated dementia. Each patient underwent two scans, performed in a 1.5-T magnetic reson

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Pistoia, Francesca, Riccardo Cornia, Massimiliano Conson, et al. "Disembodied Mind: Cortical Changes Following Brainstem Injury in Patients with Locked-in Syndrome." Open Neuroimaging Journal 10, no. 1 (2016): 32–40. http://dx.doi.org/10.2174/1874440001610010032.

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Locked-in syndrome (LIS) following ventral brainstem damage is the most severe form of motor disability. Patients are completely entrapped in an unresponsive body despite consciousness is preserved. Although the main feature of LIS is this extreme motor impairment, minor non-motor dysfunctions such as motor imagery defects and impaired emotional recognition have been reported suggesting an alteration of embodied cognition, defined as the effects that the body and its performances may have on cognitive domains. We investigated the presence of structural cortical changes in LIS, which may accoun

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Yang, Huanqing, Hua Xu, Qingfeng Li, et al. "Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls." General Psychiatry 32, no. 2 (2019): e100005. http://dx.doi.org/10.1136/gpsych-2018-100005.

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BackgroundWith an aggravated social ageing level, the number of patients with Alzheimer’s disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer’s disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic.AimsThe purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC).Methods20 AD patients, 21 aMCIs and 25 NC were recr

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Bahchevanov, Karamfil M., Penka A. Atanassova, Kostadin A. Chompalov, et al. "Cortisol Correlates with Structural Magnetic Resonance Imaging Parameters in Middle Aged Bulgarian Patients with Metabolic Syndrome: A Pilot Study." Folia Medica 60, no. 4 (2018): 546–52. http://dx.doi.org/10.2478/folmed-2018-0029.

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Abstract Background: There is a dose-dependent relationship between chronically increased cortisol levels and the number of metabolic syndrome (MetS) components. Both cortisol and MetS are linked to various brain abnormalities. Aim: To investigate an association of MetS components and salivary cortisol levels with cortical thickness in middle-aged Bulgarian patients with MetS. Materials and methods: We examined 26 healthy volunteers (mean age 50, 16±3.1 yrs) divided into two groups depending on whether or not they were diagnosed with MetS. Salivary cortisol was sampled and tested at two time p

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Zdanovskis, Nauris, Ardis Platkājis, Andrejs Kostiks, and Guntis Karelis. "Structural Analysis of Brain Hub Region Volume and Cortical Thickness in Patients with Mild Cognitive Impairment and Dementia." Medicina 56, no. 10 (2020): 497. http://dx.doi.org/10.3390/medicina56100497.

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Background and Objectives: A complex network of axonal pathways interlinks the human brain cortex. Brain networks are not distributed evenly, and brain regions making more connections with other parts are defined as brain hubs. Our objective was to analyze brain hub region volume and cortical thickness and determine the association with cognitive assessment scores in patients with mild cognitive impairment (MCI) and dementia. Materials and Methods: In this cross-sectional study, we included 11 patients (5 mild cognitive impairment; 6 dementia). All patients underwent neurological examination,

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Lavagnino, L., F. Amianto, B. Mwangi, et al. "Identifying neuroanatomical signatures of anorexia nervosa: a multivariate machine learning approach." Psychological Medicine 45, no. 13 (2015): 2805–12. http://dx.doi.org/10.1017/s0033291715000768.

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BackgroundThere are currently no neuroanatomical biomarkers of anorexia nervosa (AN) available to make clinical inferences at an individual subject level. We present results of a multivariate machine learning (ML) approach utilizing structural neuroanatomical scan data to differentiate AN patients from matched healthy controls at an individual subject level.MethodStructural neuroimaging scans were acquired from 15 female patients with AN (age = 20, s.d. = 4 years) and 15 demographically matched female controls (age = 22, s.d. = 3 years). Neuroanatomical volumes were extracted using the FreeSur

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Gerritsen, L., L. van Velzen, L. Schmaal, et al. "Childhood maltreatment modifies the relationship of depression with hippocampal volume." Psychological Medicine 45, no. 16 (2015): 3517–26. http://dx.doi.org/10.1017/s0033291715001415.

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Background.Childhood maltreatment (CM) may modify the relationship between major depressive disorder (MDD) and hippocampal volume reduction. To disentangle the impact of MDD and CM on hippocampal volume we investigated the association between MDD and hippocampal volume in persons with and without a history of CM in two independent cohorts.Method.We used data of 262 participants from the Netherlands Study of Depression and Anxiety (NESDA) (mean age 37 years, 32% male) and 636 participants from the SMART-Medea study (mean age 61 years, 81% male). In both studies a 12-month diagnosis of MDD and C

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Molent, Cinzia, Eleonora Maggioni, Filippo Cecchetto, et al. "Reduced cortical thickness and increased gyrification in generalized anxiety disorder: a 3 T MRI study." Psychological Medicine 48, no. 12 (2017): 2001–10. http://dx.doi.org/10.1017/s003329171700352x.

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AbstractBackgroundAlthough the study of the neuroanatomical correlates of generalized anxiety disorder (GAD) is gaining increasing interest, up to now the cortical anatomy of GAD patients has been poorly investigated and still no data on cortical gyrification are available. The aim of the present study is to quantitatively examine the cortical morphology in patients with GAD compared with healthy controls (HC) using magnetic resonance imaging (MRI). To the best of our knowledge, this is the first study analyzing the gyrification patterns in GAD.MethodsA total of 31 GAD patients and 31 HC under

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Wei, Dongtao, Kangcheng Wang, Jie Meng, et al. "The reductions in the subcallosal region cortical volume and surface area in major depressive disorder across the adult life span." Psychological Medicine 50, no. 3 (2019): 422–30. http://dx.doi.org/10.1017/s0033291719000230.

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AbstractBackgroundImaging studies have shown that the subcallosal region (SCR) volume was decreased in patients with major depressive disorder (MDD). However, whether the volumetric reductions in the SCR are due to thinning of the cortex or a loss of surface area (SA) remains unclear. In addition, the relationship between cortical measurements of the SCR and age through the adult life span in MDD remains unclear.MethodsWe used a cross-sectional design from 114 individuals with MDD and 112 matched healthy control (HC) individuals across the adult life span (range: 18–74 years). The mean cortica

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Pravatà, Emanuele, Maria A. Rocca, Paola Valsasina, et al. "Gray matter trophism, cognitive impairment, and depression in patients with multiple sclerosis." Multiple Sclerosis Journal 23, no. 14 (2017): 1864–74. http://dx.doi.org/10.1177/1352458517692886.

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Background: Cognitive impairment and depression frequently affects patients with multiple sclerosis (MS). However, the relationship between the occurrence of depression and cognitive impairment and the development of cortical atrophy has not been fully elucidated yet. Objectives: To investigate the association of cortical and deep gray matter (GM) volume with depression and cognitive impairment in MS. Methods: Three-dimensional (3D) T1-weighted scans were obtained from 126 MS patients and 59 matched healthy controls. Cognitive impairment was assessed using the Brief Repeatable Battery of Neuro

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Novo, Ana Margarida, Sonia Batista, Carolina Alves, et al. "The neural basis of fatigue in multiple sclerosis." Neurology: Clinical Practice 8, no. 6 (2018): 492–500. http://dx.doi.org/10.1212/cpj.0000000000000545.

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BackgroundFatigue is a frequent disabling symptom in multiple sclerosis (MS), but its pathophysiology remains incompletely understood. This study aimed to explore the underlying neural basis of fatigue in patients with MS.MethodsWe enrolled 60 consecutive patients with MS and 60 healthy controls (HC) matched on age, sex, and education. Fatigue was assessed using the Portuguese version of the Modified Fatigue Impact Scale (MFIS). All participants underwent 3T brain MRI (conventional and diffusion tensor imaging [DTI] sequences). White matter (WM) focal lesions were identified and T1/T2 lesion v

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Sasabayashi, Daiki, Yoichiro Takayanagi, Tsutomu Takahashi, et al. "Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State." Schizophrenia Bulletin 46, no. 4 (2020): 834–45. http://dx.doi.org/10.1093/schbul/sbaa011.

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Abstract Previous structural magnetic resonance imaging studies of psychotic disorders have demonstrated volumetric alterations in subcortical (ie, the basal ganglia, thalamus) and temporolimbic structures, which are involved in high-order cognition and emotional regulation. However, it remains unclear whether individuals at high risk for psychotic disorders with minimal confounding effects of medication exhibit volumetric changes in these regions. This multicenter magnetic resonance imaging study assessed regional volumes of the thalamus, caudate, putamen, nucleus accumbens, globus pallidus,

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Derome, Mélodie, Emiliana Tonini, Daniela Zöller, Marie Schaer, Stephan Eliez, and Martin Debbané. "Developmental Trajectories of Cortical Thickness in Relation to Schizotypy During Adolescence." Schizophrenia Bulletin 46, no. 5 (2020): 1306–16. http://dx.doi.org/10.1093/schbul/sbaa020.

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Abstract Investigating potential gray matter differences in adolescents presenting higher levels of schizotypy personality traits could bring further insights into the development of schizophrenia spectrum disorders. Research has yet to examine the morphological correlates of schizotypy features during adolescence prospectively, and no information is available on the developmental trajectories from adolescence to adulthood. We employed mixed model regression analysis to investigate developmental trajectories of cortical thickness (CT) in relation to schizotypy dimensions in a cohort of 109 ado

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Li, Yadi, Haibo Dong, Feng Li, et al. "Microstructures in striato-thalamo-orbitofrontal circuit in methamphetamine users." Acta Radiologica 58, no. 11 (2017): 1378–85. http://dx.doi.org/10.1177/0284185117692170.

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Background Striato-thalamo-orbitofrontal (STO) circuit plays a key role in the development of drug addiction. Few studies have investigated its microstructural abnormalities in methamphetamine (MA) users. Purpose To evaluate the microstructural changes and relevant clinical relevance of the STO circuit in MA users using diffusion tensor imaging (DTI). Material and Methods Twenty-eight MA users and 28 age-matched normal volunteers were enrolled. 3T magnetic resonance imaging (MRI) was employed to obtain structural T1-weighted (T1W) imaging and diffusion-tensor imaging (DTI) data. Freesurfer sof

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Kline, Richard P., Elizabeth Pirraglia, Hao Cheng, et al. "Surgery and Brain Atrophy in Cognitively Normal Elderly Subjects and Subjects Diagnosed with Mild Cognitive Impairment." Anesthesiology 116, no. 3 (2012): 603–12. http://dx.doi.org/10.1097/aln.0b013e318246ec0b.

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Background Structural magnetic resonance imaging is used to longitudinally monitor the progression of Alzheimer disease from its presymptomatic to symptomatic phases. Using magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative, we tested the hypothesis that surgery would impact brain parameters associated with progression of dementia. Methods Brain images from the neuroimaging initiative database were used to study normal volunteer subjects and patients with mild cognitive impairment for the age group 55 to 90 inclusive. We compared changes in regional brain anat

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Bensassi, I., J. Lopez-Castroman, R. Calati, and P. Courtet. "Hippocampal Volume Recovery After Depression: Evidence from an Elderly Sample." European Psychiatry 41, S1 (2017): S170. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2061.

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ObjectivesStructural neuroimaging studies have revealed a consistent pattern of volumetric reductions in both the hippocampus and the anterior cingulate cortex (ACC) of individuals with a major depressive episode (MDE). This study investigated hippocampal and ACC volume differences in the elderly comparing currently depressed individuals and individuals with a past lifetime history of MDE versus healthy controls.MethodsWe studied non-demented individuals from a cohort of community-dwelling people aged 65 and over (ESPRIT study). T1-weighted magnetic resonance images were used to acquire anatom

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Chaves, Hernán, Cecilia Eugenia Rollan, Fernando Ventrice, Ismael Luis Calandri, Mauricio Franco Farez, and Paulina Yañez. "Volumetría hipocampal: análisis comparativo de los métodos de evaluación en enfermedad de Alzheimer." Revista Argentina de Radiología / Argentinian Journal of Radiology 82, no. 02 (2018): 057–63. http://dx.doi.org/10.1055/s-0038-1656522.

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Objetivo La atrofia hipocampal es uno de los biomarcadores radiológicos más sensibles de la enfermedad de Alzheimer (EA) y existen diferentes métodos para evaluarla: análisis subjetivo visual (ASV), análisis objetivo manual (AOM) y análisis objetivo automático (AOA). Nos proponemos comparar esos métodos, y evaluar si el AOA presenta una confiabilidad cercana al AOM (método de referencia) y superior al ASV. Materiales y Métodos Se seleccionaron retrospectivamente imágenes de resonancia magnética (RM) fast spoiled gradient-echo (FSPGR) de 28 sujetos (14 con deterioro cognitivo leve, 7 con EA y 7

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