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Journal articles on the topic 'Freund's complete adjuvant-induced arthritis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chenchula, Santenna. "Anti-arthritic efficacy of Bombax ceiba ethanolic extract in a murine model for rheumatoid arthritis using in vivo, in vitro and radiological analysis." Bioinformation 19, no. 8 (2023): 833–39. http://dx.doi.org/10.6026/97320630019833.

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Rheumatoid arthritis (RA) is a multisystem autoimmune disease that causes discomfort, synovial membrane inflammation, peripheral joint inflammation, morning stiffness, articular tissue loss, and restricted joint movement. In the present study, we aim to explore the anti-arthritic efficacy of Bombax ceiba ethanolic extract in a Freund's Complete Adjuvant-induced arthritis, in murine model. The hot soxhlet method was used to extract dried aerial components of Bombax ceiba using an ethyl alcohol: water (70:30) ratio. Bombax ceiba ethanolic extract at two doses of 200 and 400 mg/kg was investigate

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Sabale, Ajay Sunil, Anjali Sunil Sabale, Gajendra Kale, Arati Machale, H. V. Kamble, and Supriya Hambir. "To Carry Out Anti-Arthritic Activity of Combination of Quercetin and Curcumin Using FCA (Freund’s Complete Adjuvant) Induced Arthritis in Laboratory Rats." Journal of Drug Delivery and Therapeutics 14, no. 3 (2024): 80–87. http://dx.doi.org/10.22270/jddt.v14i3.6463.

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To investigate anti-arthritic activity of Quercetin and Curcumin in Freund's complete adjuvant (FCA)-induced arthritis in rats. AA was induced by injecting with Freund's complete adjuvant (FCA). Rats were randomly divided into six groups with 10 mice in each group: (1) Normal group (saline), (2) Vehicle control, (3) Leflunomide (LF, 10 mg/kg), (4) Curcumin (80), (5) Quercetin (40), (6) Curcumin (80) + Quercetin (40). Male SD rats were subjected to treatment with Lut at 10 mg/kg from days 18 to 24 after immunization. Arthritic scores, tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), p

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3

Liu, Yan-li, Hai-ming Lin, Rong Zou, et al. "Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin." Acta Pharmacologica Sinica 30, no. 2 (2009): 219–27. http://dx.doi.org/10.1038/aps.2008.20.

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Zhang, Maoquan, Baolong Liu, and Zonghui Ji. "Effect of Wu-Wei-Gui-Shao decoction on complete Freund's adjuvant-induced arthritis rats." Tropical Journal of Pharmaceutical Research 19, no. 9 (2020): 1977–83. http://dx.doi.org/10.4314/tjpr.v19i9.25.

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Purpose: To investigate the anti-rheumatic potential of Wu-Wei-Gui-Shao decoction (WGD) and its possible mechanism of action. Methods: Adjuvant arthritis (AA) rats were established using complete Freund's adjuvant. The rats were then given different doses of WGD (100, 200, and 400 mg/kg, for 28 days). The anti-arthritic effects of WGD were evaluated. Furthermore, the in vitro anti-arthritic effects of WGD and its related mechanisms were also determined in MH7A cells. Results: WGD (100 - 400 mg/kg) exhibited significant anti-rheumatic properties after 28 days of treatment, inhibitin

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5

Kim, Jae-Hyo, Hee-Kee Kim, Yong-Il Park, et al. "Moxibustion at ST36 Alleviates Pain in Complete Freund's Adjuvant-Induced Arthritic Rats." American Journal of Chinese Medicine 34, no. 01 (2006): 57–67. http://dx.doi.org/10.1142/s0192415x06003631.

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This study was to investigate the antinociceptive effects of moxibustion in a complete Freund's adjuvant (CFA)-induced arthritic rat model, and the effects of moxibustion on immunohistochemical changes at the spinal cord level. Moxibustion was applied to the ipsilateral (right) Zusanli (ST36) acupoint to the lesion side for 9 days to CFA-induced arthritic rats. The stepping force was measured as a behavioral test, c-Fos immunohistochemistry, NO production and nNOS Western blots were examined to evaluate antinociceptive effects. Moxibustion at ST36 significantly improved the stepping force in t

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Putri, Dwi Kurnia, and Endang Darmawan. "Analgesic Activity of Chitosan in Arthritis Rats Induced by Complete Freund's Adjuvant (CFA)." PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) 19, no. 1 (2022): 132. http://dx.doi.org/10.30595/pharmacy.v19i1.13842.

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Arthritis is inflammation and pain in joints, often accompanied by stiffness and difficulty to move. The current pain treatment in arthritis is synthetic drugs that have many side effects. Chitosan’s structure similar to that of glucosamine which can be used as anti-arthritis. This study aims to evaluate the analgesic activity of chitosan in arthritic rats. The heat stimulation method with a hot plate at temperature of 55±1oC was utilized. A total of 25 male Sprague Dawley rats, weighing 150-250 g, were fed and given water ad libitum. There were grouped into group I (normal control), group II

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M., TamizhMozhi* D. Nagavalli. "CURATIVE EFFECT OF FORMONOETIN-7-O-Β-D-GLUCOPYRANOSIDE FROM METHANOLIC EXTRACT OF OPERCULINA TURPETHUM IN FREUND'S COMPLETE ADJUVANT INDUCED ARTHRITIS". iajps,csk publications 03, № 11 (2016): 1415–23. https://doi.org/10.5281/zenodo.208204.

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Objective: To investigate the anti arthritic potential of isolated compound Formonoetin-7-O-β-D-glucopyranoside from Methanolic Extract of Operculina turpethum. Methods: F-7-β-D-g was subjected to assess the anti arthritic activity by foot pat thickness, body weight measurement, rheumatoid factor, spleen index score assessment and hematological estimation using a model Complete Freund’s Adjuvant (CFA) induced arthritis in wistar rat. Result: Administration of F-7-β-D-g at the doses of 10, 20, 40, 50 mg/kg b. w. p. o exhibited statistically significant (p < 0.001) inhibition of the edema, rh

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Neeraj, Srivastava, Dashora Nipun, Menaria Jyoti, and Kumar Neeraj. "Evaluation of Anti-inflammatory and Anti-arthritic Activity of Ajmodadi Churna- A Polyherbal Formulation." International Journal of Pharmaceutical and Phytopharmacological Research 6, no. 5 (2016): 72. http://dx.doi.org/10.24896/eijppr.2016651.

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Anti-inflammatory and anti- arthritic activity of aqueous extract of Ajmodadi Churna (AJM) were evaluated by three methods namely, Carrageenan paw edema, Carrageenan induced Air Pouch Model in Rats and Freunds’ complete adjuvant Arthritis. The Carrageenan paw edema was carried out to test the effect of the extract on acute phase of inflammation. Carrageenan induced Air Pouch Model was used for local inflammation and Freunds’ complete adjuvant Arthritis was used for evaluation of chronic inflammation. Results showed that AJM have significant anti-inflammatory activity and Anti-arthritic Activit

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Alghulami, Omar, Ghaith A. Jasim, and Suzan Yousif Jasim. "Effect of Docetaxel on Matrix Metalloproteinase 1 Expression in Freund’s Adjuvant Induced Arthritis." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 33, no. 1 (2024): 163–71. http://dx.doi.org/10.31351/vol33iss1pp163-171.

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Rheumatoid arthritis is an autoimmune disorder that affects the synovial joints. It lead to inflammatory changes occur in synovial tissue, cartilage, bone, and, less frequently, extra-articular structures. Docetaxel, is an anti-neoplastic drug. Methotrexate is a treatment for early-stage rheumatoid arthritis but have 30% failure in treatment within the first year due to resistance or side effects. Matrix metalloproteinase 1 is the proteinase primarily in charge of the irreversible degradation of cartilage, bone, and tendons in the joints, which are induced by cytokines. This study aims to eval

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Lan, Zhou, Meng Wei, Lvyi Chen, Guangjing Xie, Xiao Liu, and Xiuqiao Zhang. "Role of Sinomenine on Complete Freund's Adjuvant-Induced Arthritis in Rats." IUBMB Life 68, no. 6 (2016): 429–35. http://dx.doi.org/10.1002/iub.1499.

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11

Chih, Hwa-Woei, Chun-Ching Lin, and Kung-Sheng Tang. "Anti-inflammatory Activity of Taiwan Folk Medicine "Ham-Hong-Chho" in Rats." American Journal of Chinese Medicine 23, no. 03n04 (1995): 273–78. http://dx.doi.org/10.1142/s0192415x95000328.

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"Ham-Hong-Chho" is a folk medicine in Taiwan, derived from the entire plants of Bidens pilosa L. var. minor (Blume) Sherff (Compositae), B. pilosa L. and B. chilensis DC. The anti-inflammatory effect of aqueous extracts of the three plants against paw edema induced by carrageenan and chronic arthritis induced by complete Freund's adjuvant were determined in rats. The results indicated that paw edema induced by carrageenan was significantly decreased by treatment with aqueous extracts (150 or 300 mg/kg) of all three plants ( p < 0.05) and that the effect of Bidens pilosa var. minor was the m

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Zhou, Lei, Yongli Yu, Liang Chen, et al. "Recombinant mycobacterial HSP65 in combination with incomplete Freund's adjuvant induced rat arthritis comparable with that induced by complete Freund's adjuvant." Journal of Immunological Methods 386, no. 1-2 (2012): 78–84. http://dx.doi.org/10.1016/j.jim.2012.09.002.

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Jain, Sourabh, Harshit Sharma, Megha Jha, Ragini Bundela, and Karunakar Shukla. "Anti-arthritic potential of jatropha curcas flowers extract using complete freund’s adjuvant (CFA)-induced arthritis model." IP International Journal of Comprehensive and Advanced Pharmacology 8, no. 1 (2023): 59–64. http://dx.doi.org/10.18231/j.ijcaap.2023.010.

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Jatropha curcas is a member of the euphorbiaceae family and has a number of therapeutic benefits. The anti-arthritic potential of Jatropha curcas flowers extracted using various solvents is the focus of the current investigation. The use of several antioxidant assays has been researched for qualitative and quantitative evaluation of isolated chemicals and antioxidant activity. By administering crude extract orally at dose concentrations of 200 mg/kg and 400 mg/kg to rats that had Complete Freund's adjuvant (CFA)-induced arthritis, it was possible to assess the anti-arthritic effectiveness of t

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14

Alshehri, Sultan, Shareefa A. AlGhamdi, Amira M. Alghamdi, et al. "Protective effect of fustin against adjuvant-induced arthritis through the restoration of proinflammatory response and oxidative stress." PeerJ 11 (July 26, 2023): e15532. http://dx.doi.org/10.7717/peerj.15532.

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Rheumatoid arthritis causes irreparable damage to joints. The present research sought to check fustin’s anti-arthritic efficacy against the complete Freund’s adjuvant-induced arthritis paradigm in animals by altering the inflammatory response. In the rats, complete Freund’s adjuvant was used to trigger arthritis and they received fustin at 50 and 100 mg/kg for 21 days. At regular intervals, the hind paw volume and arthritic score were assessed. After the trial period, hematological, antioxidant, pro-inflammatory cytokines, and other biochemical parameters were estimated. Fustin-treated rats sh

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Lee, Jae Yeong, Joong-Hyun Kim, Seong Soo Kang, Chun Sik Bae та Seok Hwa Choi. "The Effects of α-Viniferin on Adjuvant-Induced Arthritis in Rats". American Journal of Chinese Medicine 32, № 04 (2004): 521–30. http://dx.doi.org/10.1142/s0192415x04002168.

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This study was performed to assess the efficacy of α-viniferin (Carex humilis Leyss) on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced by a single subcutaneous injection of 0.1 ml complete Freund's adjuvant (CFA) containing 7.5 mg Mycobacterium butyricum suspended in 1 ml sterile paraffin oil into the right hind paw. Forty female Sprague-Dawley rats were injected. Righting reflex was uniformly lost and considered to be the initial point of arthritis development on day 7 after CFA injection. Rats were divided into four groups, and upon development of arthritis, tested groups

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Castro, Allyne Aparecida Dias da Silva, Roberta Mello Cachuba, Wagner de Fátima Pereira, et al. "Anti-arthritic Potential of Alocasia macrorrhizos Aqueous Extract in an Adjuvant Induced Arthritis Model." Journal of Advances in Medicine and Medical Research 37, no. 4 (2025): 166–77. https://doi.org/10.9734/jammr/2025/v37i45790.

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Rheumatoid arthritis is a chronic, inflammatory and autoimmune disease characterized by joint inflammation and systemic manifestations. This study aimed to evaluate the therapeutic potential of Alocasia macrorrhizos (EAAm) aqueous extract in an Adjuvant-Induced Arthritis (AIA) model. Holtzman strain rats were used and AIA was performed by intradermal injection of 100 µL of Freund's Complete Adjuvant (FCA) at the base of the tail, followed by injection into the left knee joint. Induced animals were treated with Phosphate-buffered saline or EAAm (100 mg/kg) during nine days. Arthritic animals of

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Uwaya, Dickson Onyenmulo, MacDonald Idu, Joy osaruese Ikonomwan, and Benjamin Ogunma Gabriel. "Anti-arthritic potential of aqueous leaf extract of Combretum platypterum (Welw) Hutch & Dalziel (Combretaceae) on rats." Journal of Current Biomedical Research 2, no. 5, September-October (2022): 440–55. http://dx.doi.org/10.54117/jcbr.v2i5.4.

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Combretum platypterum is used in the treatment of malaria, swellings, lumps, conjunctivitis, backache, fever, helminthiasis and diarrhea in ethnomedicine. This study evaluates the anti-arthritis activity of aqueous leaf extract of C.platypterum. C. platypterum leaf sample was pulverized and the powdered sample was extracted using cold maceration, which was freeze dried, and graded doses of 50, 100, 200 and 400 mg/kg of the extract were administered for the anti-arthritis property using an established formaldehyde and Complete Freund’s adjuvant induced arthritis models in rats. The result showe

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Xiaoming, Donghui Guo, Jianyong Zhao, et al. "Fisetin Attenuates Cartilage Destruction in Adjuvant-Induced Arthritis by Modulating Cartilage Cytokine Expression Correlated with Oxidative Status in the Early Phase in Experimental Animals." Folia Biologica 67, no. 4 (2019): 177–89. http://dx.doi.org/10.3409/fb_67-4.18.

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The present study was designed to evaluate the effect of Fisetin on the progression of adjuvant-induced arthritis in rats and explore the mechanisms underlying fisetin mediated immunomodulation. Adjuvant-induced arthritis (AIA) was induced by a single subcutaneous injection of Freund's complete adjuvant (FCA). AIA rats were treated with Fisetin daily via oral gavage, for a period of 28 days. Paw swelling changes were assessed and histopathological and radiographic analysis was conducted to evaluate the antiarthritic effect. Lipid peroxidation and antioxidant enzyme activities in the joint tiss

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Mali, Sharad M., Arulmozhi Sinnathambi, Chinmay U. Kapase, Subhash L. Bodhankar, and Kakasaheb R. Mahadik. "Anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund's complete adjuvant induced arthritis." Biomedicine & Aging Pathology 1, no. 3 (2011): 185–90. http://dx.doi.org/10.1016/j.biomag.2011.09.004.

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Lin, Chun-Ching, Ming-Feng Chen, and Chieh-Fu Chen. "The Anti-inflammatory Effects of Chinese Crude Drug Prescriptions on Experimental Arthritis." American Journal of Chinese Medicine 23, no. 02 (1995): 145–52. http://dx.doi.org/10.1142/s0192415x95000195.

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San-Miao-Warn (SMW), Tuhwo-Jih-Shen-Tang (TJS) and Dang-Quei-Nian-Tong-Tang (DGT) are Chinese traditional prescriptions. In this study, we evaluated the anti-inflammatory activities of these crude drug prescriptions in carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. It was found that pretreatment with SMW, TJS or DGT at a dosage of 100 mg/kg or 300 mg/kg, significantly inhibited carrageenan-induced acute arthritis. Moreover, these crude drugs also significantly suppressed the development of chronic arthritis induced by CFA. These resu

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Ibanez De Caceres, I., MA Villanua, L. Soto, AI Martin, and A. Lopez-Calderon. "IGF-I and IGF-I-binding proteins in rats with adjuvant-induced arthritis given recombinant human growth hormone." Journal of Endocrinology 165, no. 3 (2000): 537–44. http://dx.doi.org/10.1677/joe.0.1650537.

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Adjuvant-induced arthritis in rats is associated with growth failure, hypermetabolism and accelerated protein breakdown. We have previously reported that adjuvant-induced arthritis in rats results in a decrease in body weight gain, pituitary GH mRNA, circulating GH and IGF-I together with an increase in serum IGF-binding proteins (IGFBPs). The aim of this study was to analyze the role of GH in the decrease in body weight and in the alterations in the IGF-I system observed in chronic inflammation. Male Wistar rats were injected with complete Freund's adjuvant and 16 days later arthritic rats we

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Patil, Kalpesh Ramdas, Chandragouda Raosaheb Patil, Ramchandra Baburao Jadhav, Vallabh Krishnalal Mahajan, Prabhakar Raosaheb Patil, and Pradeep Sampatrao Gaikwad. "Anti-Arthritic Activity of Bartogenic Acid Isolated from Fruits ofBarringtonia racemosaRoxb. (Lecythidaceae)." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/nep148.

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The fruits ofBarringtonia racemosaare prescribed in the ayurvedic literature for the treatment of pain, inflammation and rheumatic conditions. In present investigation, activity guided isolation of bartogenic acid (BA) and its evaluation in the Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported. Among the various extracts and fractions investigated preliminarily for carrageenan-induced acute inflammation in rats, the ethyl acetate fraction displayed potent anti-inflammatory activity. Large-scale isolation and characterization using chromatography and spectral study confirme

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Zhang, Xiuying, Yanfeng Dong, Hanyu Dong, Wen Zhang, and Fang Li. "Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis." Experimental and Therapeutic Medicine 13, no. 2 (2016): 710–16. http://dx.doi.org/10.3892/etm.2016.3995.

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Chillingworth, Naomi L., and Lucy F. Donaldson. "Characterisation of a Freund's complete adjuvant-induced model of chronic arthritis in mice." Journal of Neuroscience Methods 128, no. 1-2 (2003): 45–52. http://dx.doi.org/10.1016/s0165-0270(03)00147-x.

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R, DIVISHA, USHA RANI M, GOPALA REDDY A, and KALA KUMAR B. "Boswellia serrata normalizes altered haematological indices, attenuates pain and inflammation associated with adjuvant induced arthritis in rats." Indian Journal of Animal Sciences 90, no. 5 (2020): 678–82. http://dx.doi.org/10.56093/ijans.v90i5.104603.

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A study was carried out to evaluate the anti-arthritic potential of Boswellia serrata on haematological parameters, pain and inflammation associated with adjuvant induced rheumatoid arthritis in rats. Thirty male Wistar rats were randomly divided in to 5 groups. While Group 1 served as normal control, Group 2 served as arthritic control, Groups 3, 4 and 5 served as treatment groups. Arthritis was induced in animals from Groups 2 to 5 with 0.1 ml of Freund's complete adjuvant injected intradermally into the foot pad of hindlimbs. Consequently, the onset of rheumatoid arthritis was indicated by

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Alamgeer, Umme Habiba Hasan, Ambreen Malik Uttra, and Shahid Rasool. "Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys." Bangladesh Journal of Pharmacology 10, no. 4 (2015): 807. http://dx.doi.org/10.3329/bjp.v10i4.23779.

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<p class="Abstract">The present study was commenced to evaluate the anti-arthritic effect of 70% methanol extract and <em>n</em>-butanol and aqueous fractions of <em>Berberis calliobotrys</em> using both <em>in vitro</em> and <em>in vivo</em> arthritis models. Extract and fractions were investigated<em> in vitro</em> for inhibition of protein (bovine serum and egg albumin) denaturation and human red blood cell membrane stabilization. <em>In vivo</em> anti-arthritic activity of extract and fractions at 50, 100 and 200

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Nkiru, N. Ezeani, Udu, Ibiam A., et al. "Effects of Aqueous and Ethanol Root Extracts of Rauwolfia Vomitori on Inflammatory Parameters in Complete Freund's Adjuvant-Collagen Type II Induced Arthritic Albino Rat." Pharmaceutical and Chemical Journal 5, no. 2 (2018): 72–83. https://doi.org/10.5281/zenodo.13899716.

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This study was designed to evaluate the effects of <em>Rauwolfia vomitoria</em> Oliv. ethanol and aqueous root extracts on adjuvant induced arthritis in albino rats. A total of 135 female albino rats were used for this study. The albino rats were divided into nine groups, each containing 15 animals. Arthritis was induced by intradermal administration of 0.1ml Chicken type 11 collagen-Complete Freund’s adjuvant into the left hind paw of the albino rats. Treatment with the extracts at doses of 400, 600 and 800 mg/kg body weight commenced on day 10 of the 32-day study period. The parameters

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Li, Jinghua, Tao Ke, Chao He, et al. "The Anti-Arthritic Effects of Synthetic Melittin on the Complete Freund's Adjuvant-Induced Rheumatoid Arthritis Model in Rats." American Journal of Chinese Medicine 38, no. 06 (2010): 1039–49. http://dx.doi.org/10.1142/s0192415x10008457.

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Bee venom (BV) has been used for millennia in Chinese traditional medicine to treat rheumatoid arthritis (RA). However, its components and mechanism remain unclear, which has hampered its development and application for the treatment of RA. In this study, we examined the anti-arthritis effects of melittin, which composes nearly 50% of the dry weight of whole BV, on the complete Freund's adjuvant-induced (CFA-induced) RA model in rats. The RA animal models were treated with solutions of BV, melittin, and saline by injection into a specific acupoint (Zusanli). The BV and melittin treatments stat

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Lee, Jae-Dong, Su-Young Kim, Tae-Woo Kim, et al. "Anti-inflammatory Effect of Bee Venom on Type II Collagen-Induced Arthritis." American Journal of Chinese Medicine 32, no. 03 (2004): 361–67. http://dx.doi.org/10.1142/s0192415x04002016.

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Bee venom (BV) has been used to relieve pain and reduce inflammation in traditional Oriental medicine, especially in chronic inflammatory diseases such as rheumatoid arthritis (RA). We previously reported that the BV injection into a traditional acupuncture point (Zusanli) reduced arthritis-associated edema and nociceptive responses in Freund's adjuvant-induced arthritis in rats (Kwon et al., 2001). This study was designed to evaluate the anti-inflammatory and anti-cytokine effect of BV on a murine type-II collagen-induced arthritis (CIA) model. Male mice were immunized by spontaneous injectio

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G., Vijayabaskar, and Elango V. "Effect of Keelvayu Nivarana Churunam (KNC) Extract on Glycoproteins in Complete Freund's Adjuvant (CFA) induced Arthritic Rats." RESEARCH REVIEW International Journal of Multidisciplinary 3, no. 12 (2018): 388–90. https://doi.org/10.5281/zenodo.2483245.

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Glycoproteins are important groups of compounds involved in the cellular function. They play a significant role in contributing to the surface properties of the cells and also important role in tumorigenesis and as mediators of immunological specificity. Carbohydrates moieties of glycoproteins have also been implicated in the transport of metabolites across cell membranes and also observed a direct relationship between glycolproteins and tumorigenesis. In the present study to evaluate the Keelvayu Nivarana Churunam (KNC) on glycoproteins as hexose, hexosamine and sialic acid in the plasma agai

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Taurog, J. D., S. S. Kerwar, R. A. McReynolds, G. P. Sandberg, S. L. Leary, and M. L. Mahowald. "Synergy between adjuvant arthritis and collagen-induced arthritis in rats." Journal of Experimental Medicine 162, no. 3 (1985): 962–78. http://dx.doi.org/10.1084/jem.162.3.962.

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Adjuvant arthritis (AA) in rats is susceptible to cell-mediated passive transfer. Collagen-induced arthritis (CIA) in rats is susceptible to passive transfer with antibody to type II collagen. We report here the development of strikingly severe arthritis in Lewis rats as the result of synergy between passively transferred antibody to type II collagen from rats with CIA and concanavalin A (Con A)-stimulated lymph node or spleen cells from syngeneic rats with AA. Similar synergy was seen in rats with AA given anticollagen antibody, in rats with CIA given Con A-stimulated adjuvant spleen cells, a

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Djunarko, Ipang, Nanang Fakhrudin, Arief Nurrochmad, and Subagus Wahyuono. "Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats." Journal of Pharmaceutical Sciences and Community 19, no. 2 (2022): 93–102. http://dx.doi.org/10.24071/jpsc.004746.

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Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three group

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Gupta, Veerendra, Balaji Panigrahi, Subrata De, and Mukeshkumar B. Nariya. "Evaluation of the anti-arthritic activity of Rhuflex-F – A proprietary Ayurvedic herbomineral formulation in albino rats." AYU (An International Quarterly Journal of Research in Ayurveda) 44, no. 1 (2023): 30–37. http://dx.doi.org/10.4103/ayu.ayu_327_21.

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Abstract Background: Rhuflex-F is a proprietary Ayurvedic herbo-mineral formulation clinically used to combat and relieve stiffness in joints and muscles, reduce edema, restore mobility, and also effective in relieving the symptoms of other autoimmune illnesses that lead to rheumatism. Aims: The aim and objective of the research study is to evaluate the efficacy of Rhuflex-F against in vitro protein denaturation and in vivo Freund’s adjuvant-induced arthritis in albino rats. Materials and methods: In vitro inhibition of protein denaturation activity was carried out using bovine serum albumin.

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Luo, Shasha, He Li, Jingjing Liu, et al. "Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis." Chemico-Biological Interactions 319 (March 2020): 108984. http://dx.doi.org/10.1016/j.cbi.2020.108984.

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Zheng, Cong-Long, Md Aslam Hossain, Akiko Kukita, Kazunori Ohki, Toshimi Satoh, and Osamu Kohashi. "Complete Freund's Adjuvant Suppresses the Development and Progression of Pristane-Induced Arthritis in Rats." Clinical Immunology 103, no. 2 (2002): 204–9. http://dx.doi.org/10.1006/clim.2002.5205.

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Ravada, Suryachandra R., Lakshmareddy Emani, Ganeswara R. Mallula, and Trimurtulu Golakoti. "Synthesis and Biological Evaluation of Nonaprenylsulfates." Natural Product Communications 8, no. 11 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801124.

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A naturally occurring nonaprenylsulfate (1) and its synthetic analogue (2) were synthesized from substituted phenolic precursors in three steps with an overall yield of 40–45%. Both compounds exhibited potent anti-inflammatory activity against 5-lipoxygenase, and potent brine shrimp lethality. They also showed moderate anti-oxidant activity in the super oxide radical scavenging model. Nonaprenylsulfate (1) showed moderate inhibition of paw edema in Freund's Complete Adjuvant (FCA) induced model of arthritis, thus confirming its anti-inflammatory activity.

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Suseela, Prema, and Chitra Krishnan. "Anti-Arthritic Potential of Ethyl Acetate Extract of Stereospermum colais in Animal Model." Journal of Evolution of Medical and Dental Sciences 10, no. 14 (2021): 991–98. http://dx.doi.org/10.14260/jemds/2021/213.

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BACKGROUND Stereospermum colais also known as yellow snake tree is widely utilised to alleviate rheumatic pain and inflammation in the conventional medicinal system. Lapachol has been reported to be anti-inflammatory by inhibiting the production of nitric oxide (NO) and tumour necrosis factor (TNF)-alpha by means of modulating the metabolism of arachidonic acid, activation of NF-aB, suppression of nitric oxide synthase (iNOS) expression and expression of cyclooxygenase-2 (COX-2). It has also been analysed for anticancer and antioxidant activity, renal disorders, endometriosis and cardiac dysfu

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Baroroh, Hanif Nasiatul, Rupa Lesty, Esti Dyah Utami, and Nur Ayunie Zulkepli. "Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats." Acta Pharmaciae Indonesia : Acta Pharm Indo 10, no. 1 (2022): 5789. http://dx.doi.org/10.20884/1.api.2022.10.1.5789.

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Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves

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Zhao, Jun, Zhengyi Gu, Tao Liu, et al. "Anti-arthritic effects of total flavonoids from Juniperus sabina on complete freund's adjuvant induced arthritis in rats." Pharmacognosy Magazine 12, no. 47 (2016): 178. http://dx.doi.org/10.4103/0973-1296.186346.

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Doncheva, Nina, Anita Mihaylova, Hristina Zlatanova, Mariya Ivanovska, Delian Delev, and Ilia Kostadinov. "Immunomodulatory properties of cholecalciferol in rats with experimentally induced inflammation." Pharmacia 71 (May 30, 2024): 1–9. https://doi.org/10.3897/pharmacia.71.e122410.

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The study aimed to investigate anti-inflammatory and immunomodulatory effects of cholecalciferol (vitamin D<sub>3</sub>) in rats with complete Freund's adjuvant-induced arthritis (AIA) and lipopolysaccharide (LPS)-induced inflammation. In the first experiment, rats were treated with cholecalciferol 14 days before or from the day of induction of arthritis. In the second set-up, animals received cholecalciferol for 14 days which was followed by LPS injection. TNF (tumour necrosis factor)-alpha, IL (interleukin)-1β, TGF (transforming growth factor)-β1 levels were measured by enzyme linked immunos

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Zhong, Jian, Taotao Ma, Cheng Huang та ін. "Flavonoids from Litsea coreana Decreases TNF-α Secretion from Peritoneal Macrophages in Adjuvant-Induced Arthritis Rats via UPR Pathway". American Journal of Chinese Medicine 42, № 04 (2014): 905–19. http://dx.doi.org/10.1142/s0192415x14500578.

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Macrophages play a crucial role in rheumatoid arthritis (RA). Their activation is the initial step of RA. This study was designed to detect the effects of total flavonoids from Litsea coreana Levl. (TFLC) on the complete Freund's adjuvant-induced (CFA-induced) arthritis (AA) in rats and to explore whether inflammatory cytokines were induced by the IRE1/mTORC1/TNF-α-dependant mechanism in peritoneal macrophages. In vivo, our data indicated that TFLC (100, 200 mg/kg, i.g. × 10 days) could significantly suppress secondary paw swelling and serum levels of TNF-α and IL-1β. Histopathological figures

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Sadalage, Nikita A., Nayeem A. Khatib, Sunil S. Jalalpure, Shrinivas Patil, and Mrityunjaya B. Ullagaddi. "Ventoluft Polyherbal formulation modulates Freund’s Complete Adjuvant induced arthritis in experimental rats." International Journal of Ayurvedic Medicine 12, no. 3 (2021): 523–28. http://dx.doi.org/10.47552/ijam.v12i3.2132.

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Background: Ventoluft Polyherbal formulation composes multiple traditional medicinal plants composed of various anti-inflammatory agents. Hence, the present study aimed to investigate the effect of Ventoluft Polyherbal formulation on Freund’s complete adjuvant-induced arthritic male Wistar rats. Materials and methods: The study included thirty-six rats, containing six in each. Arthritis was induced by injecting FCA (0.1ml) in joints of the right sub-plantar region of rats in negative control and all test groups i.e. (20, 40, and 80mg/kg p.o) for 28 days except normal group. A positive control,

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Ezeani, Nkiru N. "Effects of Rauwolfa vomitoria (Akata) and Olax subscorpioidea (Asaja) Roots on Hematology of Chicken Type II Collagen-Freund’s Adjuvant-induced Rheumatoid Arthritis in Albino Rats." NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES 5, no. 2 (2024): 57–71. http://dx.doi.org/10.59298/nijrms/2024/5.2.05771.

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This study evaluated the effects of ethanol and aqueous root extracts of Rauwolfia vomitoria and Olax subscorpioidea on Chicken type II collagen in Complete Freund’s Adjuvant-induced arthritis in albino rats. A total of 225 albino rats, weighing between 120-200 g, were used and divided into 15 groups of 15 rats each. Rheumatoid Arthritis (RA) was induced by administering 0.1 ml of Chicken type II-Complete Freund’s Adjuvant into the left hind paw. The study duration was 32 days, during which the arthritic rats were treated with Rauwolfia vomitoria and Olax subscorpioidea root extracts at doses

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Kang, Seong Soo, Sok Cheon Pak, and Seok Hwa Choi. "The Effect of Whole Bee Venom on Arthritis." American Journal of Chinese Medicine 30, no. 01 (2002): 73–80. http://dx.doi.org/10.1142/s0192415x02000089.

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This study was performed to assess the clincotherapeutic effect of whole venom of honeybee (Apis mellifera) in adjuvant-induced arthritic rat. Ninety Sprague-Dawley male rats were injected with complete Freund's adjuvant (CFA). Adjuvant arthritis was produced by a single subcutaneous injection of 1 mg Mycobacterium butyricum suspended in 0.1 ml paraffin oil into the right hind paw. Righting reflex was uniformly lost and considered to be the point of arthritis development on day 14 after CFA injection. The experiments were divided into three groups. When arthritis was developed in the rat, test

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Taşçı Bozbaş, Gülnur. "Effect of Ozone in Freund’s Complete Adjuvant-Induced Arthritis." Archives of Rheumatology 33, no. 2 (2018): 137–42. http://dx.doi.org/10.5606/archrheumatol.2018.6371.

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Wang, Yanming, Tao He, Zhiming Li, and Shujun Gai. "Effect of ethanol extract of Punica granatum L against Freund’s complete adjuvant-induced arthritis in rats." Tropical Journal of Pharmaceutical Research 18, no. 3 (2021): 591–95. http://dx.doi.org/10.4314/tjpr.v18i3.21.

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Purpose: To investigate the protective effect of ethanol extract of P. granatum against arthritis in rat model. Methods: Twenty-six adult male Wistar rats (120 - 150 g) were separated into four groups (n = 6): normal control, arthritic control and two treatment groups. With the exception of normal control group, arthritis was induced by intraplantar administration of Freund’s complete adjuvant (FCA) on the 1st day of drug administration. The arthritic control group was not treated, while the treatment groups received extract orally at 500 or 750 mg/kg for the period of 4 weeks and at the

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Ratkay, L. G., L. Zhang, J. Tonzetich, and J. D. Waterfield. "Complete Freund's adjuvant induces an earlier and more severe arthritis in MRL-lpr mice." Journal of Immunology 151, no. 9 (1993): 5081–87. http://dx.doi.org/10.4049/jimmunol.151.9.5081.

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Abstract A study was performed on the effect of CFA on the spontaneous arthritis of MRL-lpr mice. The development of swelling and erythema was monitored for 1 mo after injecting 13- to 14-wk-old mice intradermally with CFA, at which time the histopathology of the joints and serologic responses to extracellular matrix proteins were investigated. In a series of six experiments, 67 to 82% of mice showed early clinical evidence of arthritis in contrast to the low percentage observed in control animals. Similarly, the histopathologic analyses on the CFA-injected mice indicated a significantly highe

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Patil, ChandragoudaR, SachinS Patil, UmeshB Mahajan, SameerN Goyal, and Sateesh Belemkar. "Homoeopathic drug dilutions of Thuja occidentalis attenuate complete Freund's adjuvant-induced arthritis in Wistar rats." Indian Journal of Research in Homoeopathy 12, no. 4 (2018): 202. http://dx.doi.org/10.4103/ijrh.ijrh_49_18.

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BEN, INEMESIT, Eric Woode, George Koffuor, Eric BoakyeGyasi, and Nicholas Titiloye. "Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freund's adjuvant-induced arthritis." Journal of Intercultural Ethnopharmacology 6, no. 2 (2017): 1. http://dx.doi.org/10.5455/jice.20170218092913.

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Chung, J. I., S. Barua, B. H. Choi, B. H. Min, H. C. Han, and E. J. Baik. "Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium." Osteoarthritis and Cartilage 20, no. 4 (2012): 314–22. http://dx.doi.org/10.1016/j.joca.2012.01.005.

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