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1

Rijks, L. G. "Friedewald formula." Clinical Chemistry 41, no. 5 (1995): 761. http://dx.doi.org/10.1093/clinchem/41.5.761.

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2

Langlois, Michel R., and Pieter-Jan Briers. "Concordance of apolipoprotein B concentration with the Friedewald, Martin-Hopkins, and Sampson formulas for calculating LDL cholesterol." Biochemia medica 32, no. 1 (2022): 51–61. http://dx.doi.org/10.11613/bm.2022.010704.

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Two new formulas, the Martin-Hopkins and the Sampson formula, were recently developed to overcome shortcomings of the Friedewald formula for calculating LDL-cholesterol. We aimed to compare the concordance of the two formulas with apolipoprotein B (apoB), a surrogate marker of the number of LDL particles. In a study of serum lipid data of 1179 patients who consulted the AZ St-Jan Hospital Bruges for cardiovascular risk assessment, the correlation and concordance of the Friedewald, Martin-Hopkins and Sampson formulas with apoB concentration, measured by immunonephelometry, were determined and c
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3

Kanani, Dhara N., and Avanish Mishra. "Comparison of Different estimated Formulas with Direct Estimation of Low-density Lipoprotein Cholesterol." Indian journal of Medical Biochemistry 21, no. 2 (2017): 151–56. http://dx.doi.org/10.5005/jp-journals-10054-0040.

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ABSTRACT Introduction Recent recommendations of the Adult Treatment Panel and the Adolescents Treatment Panel of the National Cholesterol Education Program make the low-density lipoprotein cholesterol (LDL-C) levels in serum the basis of classification and management of hypercholesterolemia. This makes accurate reporting of LDL-C decisive in the management of coronary heart disease (CHD). Direct measurement of LDL by homogeneous method is accurate but reagent is costly. Therefore, we have to compare different calculated LDL values with direct LDL (D-LDL) values. Aim The aim of this study was (
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4

Dintshi, Mogomotsi, Ngalulawa Kone, and Siyabonga Khoza. "Comparison of measured LDL cholesterol with calculated LDL-cholesterol using the Friedewald and Martin-Hopkins formulae in diabetic adults at Charlotte Maxeke Johannesburg Academic Hospital/NHLS Laboratory." PLOS ONE 17, no. 12 (2022): e0277981. http://dx.doi.org/10.1371/journal.pone.0277981.

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Background The National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) and the European Society of Cardiology recommend using low-density lipoprotein cholesterol (LDL-C) as a treatment target for cholesterol lowering therapy. The Friedewald formula underestimates LDL-C in non-fasted and hypertriglyceridemia patients. This study aimed to compare measured LDL-C to calculated LDL-C in diabetic patients using the Friedewald and Martin-Hopkins formulae. Methods The data of 1 247 adult diabetes patients were retrospectively evaluated, and included triglycerides (TG), LDL-C,
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5

Parvin, Mimi, Muhammad Saiedullah, Aminul Haque Khan, Muhammad Rezwanur Rahman, and Md Saiful Islam. "Validation of the Modified Friedewald’s Formula to Calculate Low-density Lipoprotein Cholesterol in Bangladeshi Population." Journal of Bangladesh College of Physicians and Surgeons 30, no. 3 (2012): 141–44. http://dx.doi.org/10.3329/jbcps.v30i3.12463.

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Objective: A modification of Friedewald’s formula was proposed to calculate LDL cholesterol in Bangladeshi population up to serum triglyceride concentration of 1000 mg/dL. The aim of this study was to validate the modification of Friedewald’s formula in Bangladeshi population.Methods: Serum total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol concentrations were measured in specimens obtained form 314 adult Bangladeshi subjects selected conveniently. LDL cholesterol concentrations were also calculated by modified Friedewald’s formula and
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6

Basir, Hassan, Shahram Bagheri, and Mahlagha Zahedi. "Effect of low serum triglyceride on LDL-cholestrol estimation by friedewald formula." Revista Latinoamericana de Hipertensión V15, no. 1 (2020): págs 21–25. https://doi.org/10.5281/zenodo.4074192.

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<strong>Abstract</strong> The aim of the current study was to investigate the impact of low serum triglyceride (TG) on LDL-cholestrol estimation by Friedewald formula. Methods: Serum samples were taken from 540 patients and divided into 4 groups based on the level of the TG 100&gt;, 100-150, 150-250 and 250-400 mg/dl. The total cholestrol (TC), TG, high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured. Then, the LDL of patients whose serum levels of TG&gt;400 was measured with the direct method and calculated as follows: Friedewald method= LDL &ndash; C (mg/ dl) = TC&n
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7

Isiksacan, Nilgun, Cennet Yildiz, Fatma Nihan Turhan Caglar, et al. "Comparison of direct low density lipoprotein cholesterol measurement with the Friedewald formula and alternative formulas." Journal of Clinical Medicine of Kazakhstan 20, no. 1 (2023): 24–30. http://dx.doi.org/10.23950/jcmk/12904.

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&lt;b&gt;Aim:&lt;/b&gt; Our aim was to compare the direct enzymatic measurement with four formulas which are used in determining the value of low density lipoprotein cholesterol (LDL-C) levels.&lt;br /&gt; &lt;b&gt;Material and methods:&lt;/b&gt; A total of 33842 patients’ files were retrospectively reviewed and data was collected. Triglyceride (TG) group 1, 2, 3, 4 and 5 were consisted of TG levels ≤99 mg/dl, 100-199 mg/dl, 200-299 mg/dl, 300-399 mg/dl and ≥ 400 mg/dl, respectively. LDL-Group 1, 2, 3, 4 and 5 were composed of LDL-C≤100 mg/dl, 101-130 mg/dl, 131-160 mg/dl, 160-190 mg/dl and &a
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8

Setyawati, Putu Ayu, Sianny Herawati, and A. A. Ngurah Subawa. "COMPARISON OF DIRECT AND INDIRECT LDL CHOLESTEROL LEVELS CALCULATIONS (FRIEDEWALD & CHEN) IN PATIENTS AT RSUP PROF. DR. I.G.N.G. NGOERAH DENPASAR." E-Jurnal Medika Udayana 13, no. 11 (2024): 69. https://doi.org/10.24843/mu.2024.v13.i11.p11.

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High LDL cholesterol levels are the risk factor for coronary heart disease. Proper measurement of LDL levels helps in determining the accuracy of evaluation and therapy. Measurement of LDL cholesterol levels can be done by direct or indirect methods. Until now, the Friedewald formula is a method that is still often used but has shortcomings. So many new calculation formulas have emerged, one of which is the Chen Formula. This study was to comparison of LDL-direct with the LDL levels measured by the Friedewald and Chen formula. This study was conducted at Prof. Dr. I.G.N.G. Ngoerah Hospital, De
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9

Lippi, U., M. S. Graziani, F. Manzato, and M. Schinella. "The Friedewald formula: statistical acrobatics?" Clinical Chemistry 32, no. 5 (1986): 909–10. http://dx.doi.org/10.1093/clinchem/32.5.909.

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10

Kazi-Aoul, T., and M. Benmiloud. "The Friedewald formula: another restriction?" Clinical Chemistry 33, no. 7 (1987): 1301. http://dx.doi.org/10.1093/clinchem/33.7.1301.

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11

Rahayu, Cahyawati, and Afisya Agriyanti. "Perbedaan Hasil Pemeriksaan Ldl Direk (Metode Homogen) Dengan Indirek (Formula Friedewald) Pada Pasien Penderita Dislipidemia Di Rumah Sakit Islam Jakarta Cempaka Putih." Anakes : Jurnal Ilmiah Analis Kesehatan 5, no. 1 (2019): 35–42. http://dx.doi.org/10.37012/anakes.v5i1.329.

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Pemeriksaan LDL metode direk (homogen) mempunyai kemampuan otomatisasi penuh dalam penentuan LDL kolesterol secara langsung. Selain itu juga memerlukan volume sampelyang kecil dan waktu pemeriksaan yang singkat, sedangkan pemeriksaan LDL kolesterol indirek (formula Friedewald) banyak digunakan, dimana kolesterol trigliserida dan HDL kolesterol diukur, kemudian LDL kolesterol dihitung dengan menggunakan rumus Friedewald. Tujuan penelitian ini adalah untuk melihat perbedaan hasil LDL direk (metode homogen) denganindirek (formula Friedewald) pada pasien penderita dislipidemia. Data diperoleh dari
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12

Rudolf, Gaško, Peter Pavlov, Zuzana Mináriková, Mária Podobová, and Ľudovít Gašpar. "Reliability of LDL cholesterol estimation (Friedewald, Martin) is not affected by the thyroid metabolism." Laboratorna Diagnostika XXIII, no. 1 (2019): 9–13. https://doi.org/10.5281/zenodo.7764443.

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Objective: The main purpose of the study is&nbsp;to determine whether hypothyroidism and/or hyperthyroidism has any significant effect on the reliability of the LDL-cholesterol (LDL-C) estimation by the Friedewald and the Martin equation. Design: Comparative Study Material and Methods: 40 patients with newly diagnosed autoimmune hypothyroidism (36 female, 4 male). Comparison of the deviations of the LDL-C assessments by the Friedewald and the Martin equation in a group of non-treated patients in an euthyreotic state. Results: The deviations in the LDL-C levels estimated by Friedewald or by Mar
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13

Sadovnikov, Pavel S., and Victor S. Gurevich. "Calculation formulas for low density lipoprotein cholesterol in cardiological practice: the more, the better?" Almanac of Clinical Medicine 53, no. 1 (2025): 43–52. https://doi.org/10.18786/2072-0505-2025-53-005.

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Monitoring of low density lipoprotein cholesterol (LDL-C) levels is a key element of anti-atherogenic therapy in patients with atherosclerotic cardiovascular diseases, especially those at high and very high risk. The target LDL-C levels ( 1.8 mmol/L for high risk and 1.4 mmol/L for very high risk) are important indicators for quality of medical care. Traditionally, the Friedewald formula has been used to estimate LDL-C, but its accuracy is limited when triglyceride (TG) levels exceed 4.5 mmol/L. This article reviews current approaches to optimization of the LDL-C calculation formulas, their ap
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14

Chowdhury, N., M. Saiedullah, MAH Khan, and MR Rahman. "Comparison of modified Friedewald’s formula with direct measurement of low-density lipoprotein cholesterol in Bangladeshi population." Bangladesh Medical Research Council Bulletin 39, no. 3 (2014): 120–23. http://dx.doi.org/10.3329/bmrcb.v39i3.20312.

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A modification of Friedewald’s formula to estimate serum low-density lipoprotein cholesterol (LDLC) up to serum triglyceride (TG) level of 11.3 mmol/L in Bangladeshi population has recently been published. The aim of this study was to compare the modified formula with direct measurement of LDLC in Bangladeshi population in a different setting. One thousand and fifty two specimens from adult subjects were analyzed. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), LDLC and TG were measured by standard methods. The modified Friedewald’s formula was applied to estimate LD
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15

Massé, Jacques. "SI Units and the Friedewald Formula." Annals of Internal Medicine 117, no. 10 (1992): 876. http://dx.doi.org/10.7326/0003-4819-117-10-876_1.

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16

Scanu, A. M. "Lipoprotein(a) further invalidates Friedewald formula." Clinical Chemistry 40, no. 11 (1994): 2115. http://dx.doi.org/10.1093/clinchem/40.11.2115.

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17

Ortega, R., V. Pardo, and F. Lozano. "848 THE FRIEDEWALD FORMULA IN RUNNERS." Medicine & Science in Sports & Exercise 26, Supplement (1994): S152. http://dx.doi.org/10.1249/00005768-199405001-00850.

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18

Rosales-Rimache, Jaime, Jeisson Apaza-Condori, Jhonatan Rabanal-Sanchez, Jari Li, and Fernando Soncco-Llulluy. "Comparison of the Friedewald and Vujovic methods with the calculated LDL concentration in a biochemical auto-analyzer." Medwave 24, no. 04 (2024): e2775-e2775. http://dx.doi.org/10.5867/medwave.2024.04.2775.

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Objective To compare the concentration of Low-Density Lipoprotein (LDL-c) obtained using the Friedewald formula with those obtained directly with the RAYTO CHEMRAY 120 autoanalyzer. Methods Cross-sectional study. We evaluated outpatients with a medical request for a lipid profile study (total cholesterol, triglycerides, LDL, and HDL). The analyses were carried out in a RAYTO CHEMRAY 120 autoanalyzer under the principle of spectrophotometry. We obtained LDL-c using the Friedewald and Vujovic formulas. Results We evaluated 199 individuals whose direct LDL concentration averages were measured by
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19

Kurschinski, D. T., D. A. Dennen, M. Garcia, and A. M. Scanu. "Plasma lipoprotein(a) and the Friedewald formula." Clinical Chemistry 35, no. 10 (1989): 2156–57. http://dx.doi.org/10.1093/clinchem/35.10.2156.

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20

Scanu, Angelo M. "Lipoprotein(a), friedewald formula, and NCEP guidelines." American Journal of Cardiology 87, no. 5 (2001): 608–9. http://dx.doi.org/10.1016/s0002-9149(00)01440-5.

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21

Ćwiklińska, Agnieszka, Ewa Wieczorek, Anna Gliwińska, et al. "Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 5 (2020): 857–67. http://dx.doi.org/10.1515/cclm-2020-1366.

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Abstract Objectives Low-density lipoprotein cholesterol (LDL-C) is the main laboratory parameter used for the management of cardiovascular disease. The aim of this study was to compare measured LDL-C with LDL-C as calculated by the Friedewald, Martin/Hopkins, Vujovic, and Sampson formulas with regard to triglyceride (TG), LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C)/TG ratio. Methods The 1,209 calculated LDL-C results were compared with LDL-C measured using ultracentrifugation-precipitation (first study) and direct (second study) methods. The Passing-Bablok regression was app
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22

Bharathan, Nimi, Sunitha S. Nair, and Rini Raveendran. "LOW-DENSITY LIPOPROTEIN CHOLESTEROL ESTIMATION BY FRIEDEWALDS FORMULA AND BY DIRECT MEASUREMENT - A COMPARISON." International Journal of Advanced Research 10, no. 07 (2022): 689–97. http://dx.doi.org/10.21474/ijar01/15087.

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Introduction: Low-density lipoprotein cholesterol (LDL-C) levels in serum is the basis of diagnosis, classification and management of hypercholesterolemia as per the current recommendations of the Adult Treatment Panel III of National Cholesterol Education Program. Friedewalds formula is used in most laboratories to measure LDL-C levels indirectly. But, Friedewalds formula is not reliable always. Now-a-days, various homogenous assay kits for direct estimation of LDL-C based on precipitation and solubilisation using specific detergents have been evolved. This makes estimation of LDL-C levels ea
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Ephraim, Richard K. D., Emmanuel Acheampong, Swithin M. Swaray, et al. "Developing a Modified Low-Density Lipoprotein (M-LDL-C) Friedewald’s Equation as a Substitute for Direct LDL-C Measure in a Ghanaian Population: A Comparative Study." Journal of Lipids 2018 (December 31, 2018): 1–9. http://dx.doi.org/10.1155/2018/7078409.

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Despite the availability of several homogenous LDL-C assays, calculated Friedewald’s LDL-C equation remains the widely used formula in clinical practice. Several novel formulas developed in different populations have been reported to outperform the Friedewald formula. This study validated the existing LDL-C formulas and derived a modified LDL-C formula specific to a Ghanaian population. In this comparative study, we recruited 1518 participants, derived a new modified Friedewald’s LDL-C (M-LDL-C) equation, evaluated LDL-C by Friedewald’s formula (F-LDL-C), Martin’s formula (N-LDL-C), Anandaraja
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Kurniawan, Liong Boy, Windarwati Windarwati, and Budi Mulyono. "ANALYSIS OF LDL-C MEASUREMENT USING DIRECT AND FRIEDEWALD FORMULA IN TYPE 2 DIABETES MELLITUS PATIENTS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 24, no. 3 (2018): 255. http://dx.doi.org/10.24293/ijcpml.v24i3.1339.

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LDL-C is important to evaluate the risk of cardiovascular disease. LDL-C can be measured directly or by using the Friedewald equation. Type 2 Diabetes Mellitus (DM) patients have tighter LDL-C target compared with normal population. This research is aimed to analyze the difference of LDL-C level measured by direct test and Friedewald equation in DM and non-DM. This research was a cross-sectional study using LDL-C data of 208 patients who were tested in Laboratory of Clinical Pathology, Hasanuddin University Hospital from a period of August 2015 to January 2016. LDL-C and other lipid were measu
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Alpdemir, Mehmet Fatih, and Medine Alpdemir. "Comparison of different equations for estimation of low-density lipoprotein (LDL) – cholesterol." Turkish Journal of Biochemistry 45, no. 5 (2020): 601–11. http://dx.doi.org/10.1515/tjb-2019-0260.

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AbstractObjectivesThe aim of this study was to compare low-density lipoprotein cholesterol (LDL-C) estimations using various formulas with directly measured LDL-C (d-LDL-C) in the Turkish population.Material and methodsA total of 1,478 participants who were aged between 18 and 80 were classified into five groups according to serum triglyseride (TG) concentration as follows: &lt;100, 100–199, 200–299, 300–399, and 400–1000 mg/dL. Glucose (Glu), LDL-C, total cholesterol (TC), HDL-C, TG, and HbA1C were measured with Cobas 6000 c501. d-LDL-C concentrations were measured by a homogenous direct assa
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Dakouri, Bénédicte Yékayo Kone, Amidou Toure, Marie Laure Attoungbre Hauhouot, Adele Kacou-N'douba, and Ismael Namory Karamoko. "Concordance between low density lipoprotein cholesterol concentration measurement by enzymatic method and calculation by Friedewald formula in cardiovascular risk classification." International Journal of Clinical Biochemistry and Research 10, no. 3 (2023): 217–22. http://dx.doi.org/10.18231/j.ijcbr.2023.038.

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Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is important for cardiovascular risk assessment and guiding cholesterol-lowering therapy. Due to the high cost of β-quantification (Gold standard) and time-consuming, direct measurement of LDL-C is an alternative method. However, unlike the calculation of LDL-C by Friedewald formula, there is an additional cost in terms of reagents for performing a direct LDL-C test. The current study aimed to compare direct LDL-C concentration determination to data calculated by Friedewald formula. 752 lipid profiles of 710 people with LDL-C e
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Nair, Suriyan S., Reshma Kiran, K. K. Jisna, M. B. Prathima, P. Sushith, and Janice D’sa. "Comparison of ten formulae for calculating low-density lipoprotein cholesterol with direct low-density lipoprotein cholesterol measurement." Current Medicine Research and Practice 14, no. 5 (2024): 192–99. http://dx.doi.org/10.4103/cmrp.cmrp_98_24.

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ABSTRACT Background: Accurate lipid profile assessment, mainly low-density lipoprotein cholesterol (LDL-C) measurement, is crucial for diagnosing and managing cardiovascular disease (CVD). The widely used Friedewald formula for LDL-C calculation has limitations, prompting the exploration of alternative equations. Aims: This study aims to compare ten LDL-C calculation formulas with direct measurement among study participants attending a tertiary care centre. Materials and Methods: Conducted from September 2021 to July 2022 at a tertiary healthcare centre in India, the study involved 114 partici
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Ertürk Zararsız, Gözde, Serkan Bolat, Ahu Cephe, et al. "Validation of low-density lipoprotein cholesterol equations in pediatric population." PeerJ 11 (January 5, 2023): e14544. http://dx.doi.org/10.7717/peerj.14544.

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Several studies have shown a high prevalence of dyslipidemia in children. Since childhood lipid concentrations continue into adulthood, recognition of lipid abnormalities in the early period is crucial to prevent the development of future coronary heart disease (CHD). Low density lipoprotein cholesterol (LDL-C) is one of the most used parameters in the initiation and follow-up of treatment in patients with dyslipidemia. It is a well known fact that LDL-C lowering therapy reduces the risk of future CHD. Therefore, accurate determination of the LDL-C levels is so important for the management of
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Ertürk Zararsız, Gözde, Serkan Bolat, Ahu Cephe, et al. "Validation of Friedewald, Martin-Hopkins and Sampson low-density lipoprotein cholesterol equations." PLOS ONE 17, no. 5 (2022): e0263860. http://dx.doi.org/10.1371/journal.pone.0263860.

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Background Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration is essential in cardiovascular disease diagnosis and prognosis. Sampson recently proposed a new formula for the estimation of LDL-C. However, little is known regarding the validation of this formula. Objectives This study aimed to validate this new formula with other well-known formulas in Turkish population, composed of adults. Methods A total of 88,943 participants above 18 years o
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Biyik, Ismail, Nilgun Isiksacan, Murat Koser, and Fatma Nihan Turhan Caglar. "Comparison of Alternative Formulas for Low Density Lipoprotein Cholesterol Measurement with Friedewald Formula." American Journal of Cardiology 121, no. 8 (2018): e105. http://dx.doi.org/10.1016/j.amjcard.2018.03.243.

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31

Pezeshki, Babak, Mojtaba Golrazeghi, Sayed Reza Hojati, et al. "Comparison of Formulas for Low-Density Lipoprotein (LDL) Calculation for Predicting the Risk of Metabolic Syndrome." Galen Medical Journal 9 (January 27, 2020): 1607. http://dx.doi.org/10.31661/gmj.v9i0.1607.

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Background: The correlation between serum cholesterol level and the risk of developing atherosclerosis and metabolic syndrome has been well established in previous studies. Serum low-density lipoprotein (LDL-C) measurement is conducted using different methods which are generally divided into two groups, namely direct and indirect. Using indirect methods or calculations such as the Friedewald or Iranian formula for measuring LDL, particularly in developing countries, is quite common. The present study has stepped in to compare the robustness of the extant formulas in prognosticating and determi
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Cohen, Hofit. "Why Should We Measure Low-Density Lipoprotein Cholesterol Directly? Comparison of Low-Density Lipoprotein Cholesterol Assessment by Friedewald Estimation, and Direct Measurement." Journal of the Endocrine Society 5, Supplement_1 (2021): A305. http://dx.doi.org/10.1210/jendso/bvab048.622.

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Abstract Intorduction: Plasma levels of low-density lipoprotein cholesterol (LDL-C) are an important biomarker for coronary artery disease. In clinical and research settings worldwide, levels LDL-C are often not measured and are estimated using the Friedewald equation (total cholesterol - HDL cholesterol - triglycerides)/5). Bias of either over or underestimation of LDL-C can be corrected by direct measurement of LDL-C. We assessed the precision of the Friedewald equation in a heterogonous patients population within a wide range of lipid levels. Methods: A sample of consecutive fasting lipid p
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Gillespy, William G. "Use of cholesterol/triglyceride ratio and the Friedewald formula." Clinical Chemistry 37, no. 6 (1991): 1132–33. http://dx.doi.org/10.1093/clinchem/37.6.1132a.

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34

Wang, Teh Y., Michel Haddad, and Thomas S. Wang. "Low Triglyceride Levels Affect Calculation of Low-Density Lipoprotein Cholesterol Values." Archives of Pathology & Laboratory Medicine 125, no. 3 (2001): 404–5. http://dx.doi.org/10.5858/2001-125-0404-ltlaco.

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Abstract The Friedewald formula for the calculation of low-density lipoprotein cholesterol (LDL-C) values is fairly accurate provided the triglyceride value is less than 400 mg/dL. It is not clear whether the estimation is also valid in the presence of low triglyceride and high cholesterol levels. We describe herein a patient with a low triglyceride value of approximately 50 mg/dL, a high cholesterol level, and a discrepant LDL-C level. The LDL-C level using the Friedewald calculation turned out to be much higher than the LDL-C level using direct measurement. We, therefore, suggest that in the
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35

Cohn, J. S., J. R. McNamara, and E. J. Schaefer. "Lipoprotein cholesterol concentrations in the plasma of human subjects as measured in the fed and fasted states." Clinical Chemistry 34, no. 12 (1988): 2456–59. http://dx.doi.org/10.1093/clinchem/34.12.2456.

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Abstract Lipoprotein cholesterol concentrations in plasma are routinely estimated by using the Friedewald formula, whereby very-low-density lipoprotein cholesterol (VLDL-C) is estimated to be one-fifth the plasma triglyceride concentration. Ordinarily, this formula is applied only to plasma sampled from patients in the fasted state. To determine whether lipoprotein cholesterol measurements are altered substantially in plasma sampled from nonfasting subjects, we obtained postprandial blood samples from 22 healthy subjects (nine men, 13 women, ages 22-79 years) fed a fat-rich meal (1 g fat per k
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Osorio, José Henry, and Jorge Abel Castañeda. "Comparación de la Formula de Friedewald con el método precipitado para la determinación de los niveles de colesterol LDL en bovinos." Revista de Investigaciones Veterinarias del Perú 29, no. 1 (2018): 120. http://dx.doi.org/10.15381/rivep.v29i1.14087.

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El objetivo de este estudio fue comparar dos métodos (precipitado y Friedewald) para la determinación de los valores de colesterol LDL en bovinos. Se tomaron 56 muestras de sangre de bovinos en las primeras horas de la mañana. Se determinaron los niveles de colesterol LDL en el suero mediante el método de precipitación y mediante la fórmula de Friedewald. Los resultados fueron analizados mediante un análisis de varianza de una vía. El método precipitado reportó valores (mg/dl) de 14.33, 0.36, 59.11, 58.75 y 11.21 para promedio, mínimo, máximo, rango y desviación estándar, respectivamente, y me
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Nikiema-Ndong, Rosalie, Aude Syntia Mbang Bengone, Alexandrine Nsi, et al. "Comparaison de six méthodes de dosage indirect du cholestérol LDL chez des personnes vivant avec le VIH à Libreville." International Journal of Biological and Chemical Sciences 14, no. 7 (2020): 2423–33. http://dx.doi.org/10.4314/ijbcs.v14i7.5.

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L’objectif de cette étude était, de comparer six méthodes de dosage indirect du cholestérol LDL en vue de mettre en place une méthode plus pertinente dans le suivi des modifications cardiométaboliques chez les personnes vivant avec le VIH (PVVIH) sous traitements. Il s’agissait d’une étude prospective descriptive et analytique chez des PVVIH sous antirétroviraux à Libreville, allant du 13 août au 30 novembre 2018. Les patients de plus de 15 ans ont été inclus après avoir donné leurs consentements. Le dosage du cholestérol total, cholestérol HDL, cholestérol LDL et triglycérides a requis un aut
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38

Rao, A., A. H. Parker, N. A. el-Sheroni, and M. M. Babelly. "Calculation of low-density lipoprotein cholesterol with use of triglyceride/cholesterol ratios in lipoproteins compared with other calculation methods." Clinical Chemistry 34, no. 12 (1988): 2532–34. http://dx.doi.org/10.1093/clinchem/34.12.2532.

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Abstract Low-density lipoprotein cholesterol was calculated with a formula that utilizes the triglyceride/cholesterol ratios in the different lipoprotein fractions, and also with different modifications of the Friedewald formula. Results of the former calculation correlated well with the ultracentrifugation-derived values and performed better than the other calculations at different lipid concentrations.
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39

Malve, Harshad, and Amit Asalkar. "Which LDL Value Should Clinicians Look at?" Journal of Laboratory Physicians 13, no. 02 (2021): 129–33. http://dx.doi.org/10.1055/s-0041-1729131.

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Abstract Objectives LDL cholesterol is routinely estimated by the Friedewald formula to guide the treatment of dyslipidemia. However, Friedewald equation has certain limitations, especially with high triglyceride levels. Direct methods are available for LDL estimation but have received relatively little scrutiny in the Indian setting. This study was aimed at comparing the calculative and direct methods of LDL estimation in Indian hyperlipidemic patients. Materials and Methods In this observational study, data from 380 consecutive lipid profiles of patients visiting a tertiary care hospital in
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Knopfholz, José, Caio César Diniz Disserol, Andressa Jardim Pierin, et al. "Validation of the Friedewald Formula in Patients with Metabolic Syndrome." Cholesterol 2014 (February 6, 2014): 1–5. http://dx.doi.org/10.1155/2014/261878.

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Currently, the Friedewald formula (FF) is the main method for evaluating low-density lipoprotein cholesterol (LDL-c). Recently, many limitations have emerged regarding its use, including patients with triglyceride levels ≥400 mg/dL, diabetes mellitus, and kidney or hepatic chronic diseases. We analyzed the use of the FF in patients with metabolic syndrome. We selected patients with known metabolic syndrome that fulfilled the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report and
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41

Bansal, Ekta, and Navpreet Kaur. "Does Friedewald Formula Underestimate the Risk of Ischemic Heart Disease?" Indian Journal of Clinical Biochemistry 29, no. 4 (2013): 496–500. http://dx.doi.org/10.1007/s12291-013-0392-2.

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42

Demacker, P. N. M. "Determination of low-density lipoprotein-cholesterol by the Friedewald formula." TrAC Trends in Analytical Chemistry 4, no. 9 (1985): VI—VII. http://dx.doi.org/10.1016/0165-9936(85)85002-0.

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43

Matas, C., M. Cabré, A. La Ville, et al. "Limitations of the Friedewald formula for estimating low-density lipoprotein cholesterol in alcoholics with liver disease." Clinical Chemistry 40, no. 3 (1994): 404–6. http://dx.doi.org/10.1093/clinchem/40.3.404.

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Abstract The accuracy of the Friedewald formula in estimating low-density lipoprotein (LDL) cholesterol was investigated in 47 alcoholic patients with liver disease (21 minimal-change, 26 cirrhotic) by comparing the results with those obtained by sequential preparative ultracentrifugation. In 14% of subjects with minimal-change disease, the error in the estimated LDL cholesterol was 50% +/- 9% (mean +/- SD; range 40-59%) and was related to the degree of attendant hypertriglyceridemia (r = 0.98; P &amp;lt; 0.001). A similar degree of error was observed in patients with cirrhosis, despite the ab
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44

Gaško, Rudolf, Jindřich Lacko, and Margita Hefler. "Are studies comparing only mathematical formulas for determining LDL-cholesterol superfluous?" Klin Biochem Metab 31, no. 2 (2023): 48–61. https://doi.org/10.5281/zenodo.8103924.

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Objective: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is important for guiding cholesterol-lowering therapy. Different methods currently exist to estimate LDL-C. Among them are the Friedewald, Martin-Hopkins and Sampson/NIH equations. In the last three years, many studies have been published that compare only LDL-cholesterol calculated by these equations, without comparison with measured values. The aim of this study is to confirm that, using artificial data or simulated data set, such a comparison can be made with absolute reproducibility. Design: Methodical study. Mat
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Hong, Jinyoung, Hyunjung Gu, Juhee Lee, et al. "Intuitive Modification of the Friedewald Formula for Calculation of LDL-Cholesterol." Annals of Laboratory Medicine 43, no. 1 (2023): 29–37. http://dx.doi.org/10.3343/alm.2023.43.1.29.

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46

Li, K. M., D. E. Wilcken, and N. P. Dudman. "Effect of serum lipoprotein(a) on estimation of low-density lipoprotein cholesterol by the Friedewald formula." Clinical Chemistry 40, no. 4 (1994): 571–73. http://dx.doi.org/10.1093/clinchem/40.4.571.

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Abstract The calculation of serum low-density lipoprotein cholesterol (LDL-C) by the Friedewald formula does not account for the cholesterol associated with lipoprotein(a) [Lp(a)]. To quantify the contribution of Lp(a) cholesterol to total serum cholesterol, we measured concentrations of serum Lp(a) by an ELISA and concentrations of other serum lipids and lipoproteins by standard assays in 23 normolipemic women, ages 50-60 years. In measuring serum high-density lipoprotein we found that polyethylene glycol 6000 precipitated &amp;gt; 99.8% of all Lp(a). When serum Lp(a) concentrations were &amp
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González Estrada, M., C. R. Rodríguez Ferrer, I. R. Astarloa, and E. M. Lahera. "Use of serum cholesterol/triglyceride ratio to discern for which individuals the Friedewald formula can be used confidently." Clinical Chemistry 36, no. 9 (1990): 1673–75. http://dx.doi.org/10.1093/clinchem/36.9.1673.

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Abstract The values of low-density lipoprotein cholesterol obtained according to the Friedewald formula (Clin Chem 1972; 18:499-502), or by the De Long transformation (J Am Med Assoc 1986;256:2372-7), were compared with the values obtained when the individual cholesterol/triglyceride ratio of very-low-density lipoprotein was used for estimating the contribution of this lipoprotein to the total cholesterol. We found that these formulas gave the greatest errors for individuals with a low serum cholesterol/triglyceride ratio. We propose criteria for deciding when the numerically calculated value
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48

Kapoor, Reema, Montosh Chakraborty, and Navpreet Singh. "A Leap above Friedewald Formula for Calculation of Low-Density Lipoprotein-Cholesterol." Journal of Laboratory Physicians 7, no. 01 (2015): 011–16. http://dx.doi.org/10.4103/0974-2727.154780.

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ABSTRACT Purpose: The purpose was to compare the different calculated methods of low-density lipoprotein cholesterol (LDL-C) estimation and to determine which of them correlate best with the direct method. Materials and Methods: The records of 480 samples for lipid profile were analyzed. Apart from the direct method, LDL-C was calculated by Friedewald low-density lipoprotein cholesterol method (F-LDL-C), modified Friedewald low-density lipoprotein cholesterol method (MF-LDL-C), and Anandaraja low-density lipoprotein cholesterol method (A-LDL-C). Paired t-test and Pearson correlation were evalu
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Sentí, M., J. Pedro-Botet, X. Nogués, and J. Rubiés-Prat. "Influence of intermediate-density lipoproteins on the accuracy of the Friedewald formula." Clinical Chemistry 37, no. 8 (1991): 1394–97. http://dx.doi.org/10.1093/clinchem/37.8.1394.

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Abstract Values of low-density lipoprotein (LDL) cholesterol (C) according to the Friedewald formula (Clin Chem 1972;18:499-502) were compared with those obtained by lipoprotein fractionation in 98 healthy subjects (control group), 135 specimens from patients with peripheral vascular and cerebrovascular disease (atherosclerotic group), and 45 with chronic renal failure on hemodialysis (CRF group). All had concentrations of total cholesterol between 3.23 and 7.76 mmol/L (1.25-3.00 g/L) and triglycerides less than 3.39 mmol/L (less than 3.00 g/L). The percentage error of calculated LDL-C was 4%
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Saiedullah, M., N. Chowdhury, M. A. H. Khan, S. Hayat, S. Begum, and M. R. Rahman. "Comparison of Regression Equation and Friedewald’s Formula with Direct Measurement of Low-density Lipoprotein Cholesterol in Bangladeshi Population." Journal of Scientific Research 6, no. 1 (2013): 143–52. http://dx.doi.org/10.3329/jsr.v6i1.14864.

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Friedewald’s formula (FF) is the most widely used formula in clinical practice to calculate low-density lipoprotein cholesterol (LDLC) from total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDLC). But this formula frequently underestimates LDLC. The aim of this study was to derive a regression equation (RE) to abolish the underestimation and to compare the performance of RE and FF in Bangladeshi population. RE was derived from 531 lipid profiles (equation derivation group) for the calculation of LDLC by multiple linear regression analysis. The RE was then used
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