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Journal articles on the topic 'FRK'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

WELSH, Michael, Charlotte WELSH, Maria EKMAN, et al. "The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity." Biochemical Journal 382, no. 1 (2004): 261–68. http://dx.doi.org/10.1042/bj20040285.

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Hallmarks of the inflammatory process in Type I diabetes are macrophage activation, local release of β-cell-toxic cytokines and infiltration of cytotoxic T lymphocytes. We have observed recently that mice overexpressing active FRK (fyn-related kinase)/RAK (previously named GTK/Bsk/IYK, where GTK stands for gut tyrosine kinase, Bsk for β-cell Src-homology kinase and IYK for intestinal tyrosine kinase) in β-cells exhibit increased susceptibility to β-cell-toxic events, and therefore, we now attempt to find a more precise role for FRK/RAK in these processes. Phosphopeptide mapping of baculovirus-

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2

Granot, David. "Role of tomato hexose kinases." Functional Plant Biology 34, no. 6 (2007): 564. http://dx.doi.org/10.1071/fp06207.

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Hexose phosphorylation is an essential step of sugar metabolism. Only two classes of glucose and fructose phosphorylating enzymes, hexokinases (HXK) and fructokinases (FRK), have been found in plants. Tomato (Lycopersicon esculentum Mill.) is the only plant species from which four HXK and four FRK genes have been identified and characterised. One HXK and one FRK isozyme are located within plastids. The other three HXK isozymes are associated with the mitochondria, and the other three FRK isozymes are dispersed in the cytosol. These differences in location suggest that the cytoplasmic HXK and F

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3

Annerén, Cecilia, Michael Welsh, and Leif Jansson. "Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter." American Journal of Physiology-Endocrinology and Metabolism 292, no. 4 (2007): E1183—E1190. http://dx.doi.org/10.1152/ajpendo.00168.2006.

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The FRK tyrosine kinase has previously been shown to transduce β-cell cytotoxic signals in response to cytokines and streptozotocin and to promote β-cell proliferation and an increased β-cell mass. We therefore aimed to further evaluate the effects of overexpression of FRK tyrosine kinase in β-cells. A transgenic mouse expressing kinase-active FRK under control of the insulin promoter (RIP-FRK) was studied with regard to islet endocrine function and vascular morphology. Mild glucose intolerance develops in RIP-FRK male mice of at least 4 mo of age. This effect is accompanied by reduced glucose

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4

Chandrasekharan, Subhashini, Ting Hu Qiu, Nawal Alkharouf, Kelly Brantley, James B. Mitchell, and Edison T. Liu. "Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak." Molecular and Cellular Biology 22, no. 14 (2002): 5235–47. http://dx.doi.org/10.1128/mcb.22.14.5235-5247.2002.

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ABSTRACT Frk/rak belongs to a novel family of Src kinases with epithelial tissue-specific expression. Although developmental expression patterns and functional overexpression in vitro have associated these kinases with growth suppression and differentiation, their physiological functions remain largely unknown. We therefore generated mice carrying a null mutation in iyk, the mouse homolog of Frk/rak. We report here that frk/rak−/− mice are viable, show similar growth rates to wild-type animals, and are fertile. Furthermore, a 2-year study of health and survival did not identify differences in

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5

Wang, Jun, Chang Cai, Dekang Nie, et al. "FRK suppresses human glioma growth by inhibiting ITGB1/FAK signaling." Biochemical and Biophysical Research Communications 517, no. 4 (2019): 588–95. http://dx.doi.org/10.1016/j.bbrc.2019.07.059.

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6

Bayard, Quentin, Stefano Caruso, Gabrielle Couchy, et al. "Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas." Gut 69, no. 9 (2020): 1667–76. http://dx.doi.org/10.1136/gutjnl-2019-319790.

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BackgroundInflammatory hepatocellular adenomas (IHCAs) are benign liver tumours characterised by an activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway caused by oncogenic activating mutations. However, a subset of IHCA lacks of identified mutation explaining the inflammatory phenotype.Methods657 hepatocellular adenomas developed in 504 patients were analysed for gene expression of 17 genes and for mutations in seven genes by sequencing. 22 non-mutated IHCAs were analysed by whole-exome and/or RNA sequencing.ResultsWe identified 296 IHCA (45%)

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7

You, Xiong. "Limit-Cycle-Preserving Simulation of Gene Regulatory Oscillators." Discrete Dynamics in Nature and Society 2012 (2012): 1–22. http://dx.doi.org/10.1155/2012/673296.

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In order to simulate gene regulatory oscillators more effectively, Runge-Kutta (RK) integrators are adapted to the limit-cycle structure of the system. Taking into account the oscillatory feature of the gene regulatory oscillators, phase-fitted and amplification-fitted Runge-Kutta (FRK) methods are designed. New FRK methods with phase-fitted and amplification-fitted updated are also considered. The error coefficients and the error constant for each of new FRK methods are obtained. In the numerical simulation of the two-gene regulatory system, the new methods are shown to be more accurate and m

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8

Shimada, Toshio, Taeko Hirose, Itsuro Matsumoto, and Tadaomi Aikawa. "Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals." Journal of Endocrinology 195, no. 1 (2007): 29–38. http://dx.doi.org/10.1677/joe-07-0251.

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We examined the cross-regulation of signaling between ACTH-and platelet-activating factor (PAF)-mediated steroidogenesis in the perfused guinea pig adrenal gland. Our method of in situ perfusion using an artificial medium can evaluate whether cortisol secretion in response to ACTH and PAF is interactive. Treating adrenal glands with 100 pg/ml ACTH diminished the subsequent cortisol response to 10 nM PAF. By contrast, PAF resulted in subsequent potentiation of ACTH-induced cortisol secretion. A mixture of 50 μM l-α-1-oleoyl-2-acetyl-sn-glycerol (OAG), an activator of protein kinase C (PKC), and

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9

Caescu, Cristina I., Olivier Vidal, Frédéric Krzewinski, Vlad Artenie, and Stéphane Bouquelet. "Bifidobacterium longum Requires a Fructokinase (Frk; ATP:d-Fructose 6-Phosphotransferase, EC 2.7.1.4) for Fructose Catabolism." Journal of Bacteriology 186, no. 19 (2004): 6515–25. http://dx.doi.org/10.1128/jb.186.19.6515-6525.2004.

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ABSTRACT Although the ability of Bifidobacterium spp. to grow on fructose as a unique carbon source has been demonstrated, the enzyme(s) needed to incorporate fructose into a catabolic pathway has hitherto not been defined. This work demonstrates that intracellular fructose is metabolized via the fructose-6-P phosphoketolase pathway and suggests that a fructokinase (Frk; EC 2.7.1.4) is the enzyme that is necessary and sufficient for the assimilation of fructose into this catabolic route in Bifidobacterium longum. The B. longum A10C fructokinase-encoding gene (frk) was expressed in Escherichia

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10

Drabble, Eric, Sofia Spanopoulou, Eleni Sioka, et al. "How to tie dangerous surgical knots: easily. Can we avoid this?" BMJ Surgery, Interventions, & Health Technologies 3, no. 1 (2021): e000091. http://dx.doi.org/10.1136/bmjsit-2021-000091.

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ObjectiveSecure knots are essential in all areas of surgical, medical and veterinary practice. Our hypothesis was that technique of formation of each layer of a surgical knot was important to its security.DesignEqual numbers of knots were tied, by each of three groups, using three techniques, for each of four suture materials; a standard flat reef knot (FRK), knots tied under tension (TK) and knots laid without appropriate hand crossing (NHCK). Each knot technique was performed reproducibly, and tested by distraction with increasing force, till each material broke or the knot separated complet

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11

Kustec, Aleksander. "The fusion of the imagination and the material universe: Hugh Hood, Flying a red kite (1962)." Acta Neophilologica 32 (December 1, 1999): 85–94. http://dx.doi.org/10.4312/an.32.0.85-94.

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In the first weeks of January 1957 Hugh (John Blagdon) Hood moved to Hartford, Connecticut, U. S. A, where he became Professor at Saint Joseph College. At the time Hood did not know that he was going to become one of Canada's greatest stylists and contemporary short story writers. Between January 1957 and March 1962, when he was going through a final selection o short stories for his first book, Flying a Red Kite (FRK), Hugh Hood wrote thirty-eight short stories and two novels (God Rest You Merry and Hungry Generations). The numbers show that Hood was an extremely productive writer in that per

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12

Kustec, Aleksander. "The fusion of the imagination and the material universe: Hugh Hood, Flying a red kite (1962)." Acta Neophilologica 32 (December 1, 1999): 85–94. http://dx.doi.org/10.4312/an.32.1.85-94.

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In the first weeks of January 1957 Hugh (John Blagdon) Hood moved to Hartford, Connecticut, U. S. A, where he became Professor at Saint Joseph College. At the time Hood did not know that he was going to become one of Canada's greatest stylists and contemporary short story writers. Between January 1957 and March 1962, when he was going through a final selection o short stories for his first book, Flying a Red Kite (FRK), Hugh Hood wrote thirty-eight short stories and two novels (God Rest You Merry and Hungry Generations). The numbers show that Hood was an extremely productive writer in that per

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13

Balister, Paul, Béla Bollobás, Amites Sarkar, and Mark Walters. "Sentry Selection in Wireless Networks." Advances in Applied Probability 42, no. 1 (2010): 1–25. http://dx.doi.org/10.1239/aap/1269611141.

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Let be a Poisson process of intensity one in the infinite plane ℝ2. We surround each point x of by the open disc of radius r centred at x. Now let Sn be a fixed disc of area n, and let Cr(Sn) be the set of discs which intersect Sn. Write Erk for the event that Cr(Sn) is a k-cover of Sn, and Frk for the event that Cr(Sn) may be partitioned into k disjoint single covers of Sn. We prove that P(Erk ∖ Frk) ≤ ck / logn, and that this result is best possible. We also give improved estimates for P(Erk). Finally, we study the obstructions to k-partitionability in more detail. As part of this study, we

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14

Yang, X. Y., T. Kinoshita, N. Miyano, et al. "Preliminary X-ray analysis of human Frk kinase domain." Acta Crystallographica Section A Foundations of Crystallography 64, a1 (2008): C321. http://dx.doi.org/10.1107/s0108767308089721.

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15

Shimoya, K. "Fractalkine (FRK) levels in amniotic fluid and its production during pregnancy." Molecular Human Reproduction 9, no. 2 (2003): 97–101. http://dx.doi.org/10.1093/molehr/gag009.

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16

Yu, Xiu-Zhang, Jia-Ling Yuan, Hui Ye, Ke Yi, Ming-Rong Qie, and Min-Min Hou. "TRIM44 facilitates ovarian cancer proliferation, migration, and invasion by inhibiting FRK." Neoplasma 68, no. 04 (2021): 751–59. http://dx.doi.org/10.4149/neo_2021_201128n1285.

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17

Kaneko, Hitomi, Taku Kaitsuka, and Kazuhito Tomizawa. "Response to Stimulations Inducing Circadian Rhythm in Human Induced Pluripotent Stem Cells." Cells 9, no. 3 (2020): 620. http://dx.doi.org/10.3390/cells9030620.

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Regenerative medicine and disease modeling are expanding rapidly, through the development of human-induced pluripotent stem cells (hiPSCs). Many exogeneous supplements are often used for the directed differentiation of hiPSCs to specific lineages, such as chemicals and hormones. Some of these are known to synchronize the circadian clock, like forskolin (Frk) and dexamethasone (Dex); however, the response to these stimulations has not been fully elucidated for hiPSCs. In this study, we examined the response of clock genes to synchronizing stimulation, and compared it with fully differentiated c

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18

Cao, Yunpeng, Shumei Li, Yahui Han, et al. "A new insight into the evolution and functional divergence of FRK genes in Pyrus bretschneideri." Royal Society Open Science 5, no. 7 (2018): 171463. http://dx.doi.org/10.1098/rsos.171463.

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In plants, plant fructokinases (FRKs) are considered to be the main gateway of fructose metabolism as they can phosphorylate fructose to fructose-6-phosphate. Chinese white pears ( Pyrus bretschneideri ) are one of the popular fruits in the world market; sugar content is an important factor affecting the quality of the fruit. We identified 49 FRKs from four Rosaceae species; 20 of these sequences were from Chinese white pear. Subsequently, phylogenic relationship, gene structure and micro-collinearity were analysed. Phylogenetic and exon–intron analysis classified these FRK s into 10 subfamili

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19

Mukherjee, Thiya, Mariana Ivanova, Marisela Dagda, Yoshinori Kanayama, David Granot, and A. Scott Holaday. "Constitutively overexpressing a tomato fructokinase gene (LeFRK1) in cotton (Gossypium hirsutum L. cv. Coker 312) positively affects plant vegetative growth, boll number and seed cotton yield." Functional Plant Biology 42, no. 9 (2015): 899. http://dx.doi.org/10.1071/fp15035.

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Increasing fructokinase (FRK) activity in cotton (Gossypium hirsutum L.) plants may reduce fructose inhibition of sucrose synthase (Sus) and lead to improved fibre yield and quality. Cotton was transformed with a tomato (Solanum lycopersicum L.) fructokinase gene (LeFRK1) under the control of the CMV 35S promoter. In a greenhouse, the LeFRK1 plants had increased fibre and leaf FRK activity over nonexpressing nulls, but not improved fibre length and strength. Compared with the nulls, LeFRK1 plants yielded 13–100% more seed-cotton mass per boll and more bolls per plant, and therefore more seed c

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20

Åkerblom, Björn, Cecilia Annerén, and Michael Welsh. "A role of FRK in regulation of embryonal pancreatic beta cell formation." Molecular and Cellular Endocrinology 270, no. 1-2 (2007): 73–78. http://dx.doi.org/10.1016/j.mce.2007.02.009.

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21

Jin, Guang, Hyo-Sung Jeon, Enyue Yang, and Jae Yong Park. "Mutation analysis of the FRK gene in non-small cell lung cancers." Lung Cancer 71, no. 1 (2011): 115–17. http://dx.doi.org/10.1016/j.lungcan.2010.10.002.

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22

Lee, James, Zhengyu Wang, Shiuh-Ming Luoh, William I. Wood, and David T. Scadden. "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinaseencoding gene." Gene 138, no. 1-2 (1994): 247–51. http://dx.doi.org/10.1016/0378-1119(94)90817-6.

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23

Arshad, Muhammad Sarmad, Dumitru Baleanu, Muhammad Bilal Riaz, and Muhammad Abbas. "A Novel 2-Stage Fractional Runge–Kutta Method for a Time-Fractional Logistic Growth Model." Discrete Dynamics in Nature and Society 2020 (June 10, 2020): 1–8. http://dx.doi.org/10.1155/2020/1020472.

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In this paper, the fractional Euler method has been studied, and the derivation of the novel 2-stage fractional Runge–Kutta (FRK) method has been presented. The proposed fractional numerical method has been implemented to find the solution of fractional differential equations. The proposed novel method will be helpful to derive the higher-order family of fractional Runge–Kutta methods. The nonlinear fractional Logistic Growth Model is solved and analyzed. The numerical results and graphs of the examples demonstrate the effectiveness of the method.

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24

Ogunbolude, Yetunde, Chenlu Dai, Edward T. Bagu, et al. "FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition." Oncotarget 8, no. 68 (2017): 113034–65. http://dx.doi.org/10.18632/oncotarget.22958.

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25

Brauer, Patrick M., and Angela Tyner. "RAKing in AKT: A tumor suppressor function for the intracellular tyrosine kinase FRK." Cell Cycle 8, no. 17 (2009): 2728–32. http://dx.doi.org/10.4161/cc.8.17.9389.

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26

Yamada, Yuta, Naoki Kimura, Ken‐ichi Takayama, et al. "TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma." Cancer Science 111, no. 3 (2020): 881–90. http://dx.doi.org/10.1111/cas.14295.

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27

Goel, Raghuveera Kumar, and Kiven Erique Lukong. "Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology." Cancer and Metastasis Reviews 35, no. 2 (2016): 179–99. http://dx.doi.org/10.1007/s10555-016-9623-3.

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28

McClendon, Chakia J., and W. Todd Miller. "Structure, Function, and Regulation of the SRMS Tyrosine Kinase." International Journal of Molecular Sciences 21, no. 12 (2020): 4233. http://dx.doi.org/10.3390/ijms21124233.

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Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a tyrosine kinase that was discovered in 1994. It is a member of a family of nonreceptor tyrosine kinases that also includes Brk (PTK6) and Frk. Compared with other tyrosine kinases, there is relatively little information about the structure, function, and regulation of SRMS. In this review, we summarize the current state of knowledge regarding SRMS, including recent results aimed at identifying downstream signaling partners. We also present a structural model for the enzyme and discuss the

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29

Hua, Lei, Guanghui Wang, Zhen Wang, et al. "Activation of STAT1 by the FRK tyrosine kinase is associated with human glioma growth." Journal of Neuro-Oncology 143, no. 1 (2019): 35–47. http://dx.doi.org/10.1007/s11060-019-03143-w.

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30

Boddicker, R. L., G. Hu, S. Dasari, et al. "TARGETABLE FUSIONS OF THE FRK TYROSINE KINASE IN ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA." Hematological Oncology 35 (June 2017): 59. http://dx.doi.org/10.1002/hon.2437_45.

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31

Jin, L., and R. J. Craven. "The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor." Oncogene 33, no. 3 (2013): 326–35. http://dx.doi.org/10.1038/onc.2012.589.

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32

Hu, G., S. Dasari, Y. W. Asmann, et al. "Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma." Leukemia 32, no. 2 (2017): 565–69. http://dx.doi.org/10.1038/leu.2017.309.

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33

Öberg-Welsh, Charlotte, and Michael Welsh. "Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution." Gene 152, no. 2 (1995): 239–42. http://dx.doi.org/10.1016/0378-1119(94)00718-8.

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34

Hua, Lei, Ming Zhu, Xu Song, et al. "FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation." Journal of Neuro-Oncology 119, no. 1 (2014): 49–58. http://dx.doi.org/10.1007/s11060-014-1461-y.

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35

Serfas, Michael S., and Angela L. Tyner. "Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 13, no. 6 (2003): 409–19. http://dx.doi.org/10.3727/096504003108748438.

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36

Yu, Yi, Tushar R. Bhangale, Jesen Fagerness, et al. "Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration." Human Molecular Genetics 20, no. 18 (2011): 3699–709. http://dx.doi.org/10.1093/hmg/ddr270.

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37

YANG, Xiaoyan, Takayoshi KINOSHITA, Masaki GOUDA, Koichi YOKOTA, and Toshiji TADA. "A Silent Mutation Made Possible Efficient Production of Active Human Frk Tyrosine Kinase inEscherichia coli." Bioscience, Biotechnology, and Biochemistry 74, no. 1 (2010): 125–28. http://dx.doi.org/10.1271/bbb.90648.

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38

Zhou, Xiuping, Lei Hua, Weijian Zhang, et al. "FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling." Journal of Neuro-Oncology 110, no. 1 (2012): 9–19. http://dx.doi.org/10.1007/s11060-012-0933-1.

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39

Karolina Br. Sebayang, L., and S. Utami. "Social Capital and Unseen Inequalities: The Case of Tourism Cluster Dialogue Forum (FRK- Forum Rembuk Klaster)." KnE Social Sciences 3, no. 10 (2018): 249. http://dx.doi.org/10.18502/kss.v3i10.3133.

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40

Pilati, Camilla, Eric Letouzé, Jean-Charles Nault, et al. "Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation." Cancer Cell 25, no. 4 (2014): 428–41. http://dx.doi.org/10.1016/j.ccr.2014.03.005.

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41

Shi, Qiong, Xu Song, Jun Wang та ін. "FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/β-catenin Complex Formation". Journal of Molecular Neuroscience 55, № 1 (2014): 32–41. http://dx.doi.org/10.1007/s12031-014-0355-y.

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42

Miah, S., C. A. S. Banks, Y. Ogunbolude, et al. "BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential." Science Advances 5, no. 10 (2019): eaaw3113. http://dx.doi.org/10.1126/sciadv.aaw3113.

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The tumor-suppressing function of SMAD4 is frequently subverted during mammary tumorigenesis, leading to cancer growth, invasion, and metastasis. A long-standing concept is that SMAD4 is not regulated by phosphorylation but ubiquitination. Our search for signaling pathways regulated by breast tumor kinase (BRK), a nonreceptor protein tyrosine kinase that is up-regulated in ~80% of invasive ductal breast tumors, led us to find that BRK competitively binds and phosphorylates SMAD4 and regulates transforming growth factor–β/SMAD4 signaling pathway. A constitutively active BRK (BRK-Y447F) phosphor

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43

Jing, Zhi-Fei, Jian-Bin Bi, Ze-Liang Li, et al. "miR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis." OncoTargets and Therapy Volume 12 (April 2019): 2713–27. http://dx.doi.org/10.2147/ott.s199238.

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44

Anneren, Cecilia, Cecilia Lindholm, Vitezslav Kriz, and Michael Welsh. "The FRK / RAK-SHB Signaling Cascade: A Versatile Signal- Transduction Pathway that Regulates Cell Survival, Differentiation and Proliferation." Current Molecular Medicine 3, no. 4 (2003): 313–24. http://dx.doi.org/10.2174/1566524033479744.

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45

Bianchi, Michele Wolfe, Catherine Damerval, and Nicole Vartanian. "Identification of proteins regulated by cross-talk between drought and hormone pathways in Arabidopsis wild-type and auxin-insensitive mutants, axr1 and axr2." Functional Plant Biology 29, no. 1 (2002): 55. http://dx.doi.org/10.1071/pp01113.

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Ten proteins differentially regulated by progressive drought stress in Arabidopsis Columbia wild-type, axr1-3 and axr2-1auxin-insensitive mutants, were identified from internal amino acid microsequencing. These proteins fell into two categories: (i) stress-related proteins, known to be induced by rapid water stress via abscisic acid (ABA)-dependent or -independent pathways [late embryogenesis abundant (LEA)-like and heat shock cognate (HS) 70, respectively], or in response to pathogens or oxidative stress [β-1,3 glucanase (BG), annexin] and (ii) metabolic enzymes [glutamine synthetase (GS), fr

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46

Ly, Brenda, and Claudiu V. Cotta. "The Utility of the BIOMED-2 Primers in the Detection of 2 Clonal, B-Lymphoproliferative Disorders Simultaneously Involving the Same Site." Archives of Pathology & Laboratory Medicine 137, no. 11 (2013): 1654–59. http://dx.doi.org/10.5858/arpa.2012-0666-oa.

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Context.—Molecular tests for clonality performed on atypical lymphoid lesions may yield abnormal results because of the coexistence of monoclonal B lymphocytosis or monoclonal gammopathy of undetermined significance in the sample investigated. Objective.—To investigate the ability of the BIOMED-2 sets of primers to identify 2 clonal populations in the same formalin-fixed, paraffin-embedded tissue sample. Design.—Ten cases with 2 B-lymphoproliferative disorders at the same site were analyzed using 5 BIOMED-2 primer sets (IGH FR1, FR2, FR3, IGK VJ, and IGK VKde). Results.—All 10 cases (100%) sho

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47

Joshi, Pramod S., Yogesh B. Patil, Bhagyashri Nagarkar, Tania S. Paul, and Kishori G. Apte. "In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L." Journal of Natural Remedies 21, no. 1 (2021): 51. http://dx.doi.org/10.18311/jnr/2021/26255.

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<em>Ficus religiosa</em> L. (FR) and <em>Morus alba</em> L. (ML) belonging to the family Moraceae have been tested as novel herbal agents for hair growth promotion and Hair Follicles (HFs) regeneration in BALB/c athymic nude mouse model. Current study tested different mixtures of 5% aqueous fractions: Test 1 (ML2+ML3+ML4+FR4), Test 2 (FR1+FR2+FR4), or Test 3 (ML2+ML3+ML4+FR1+FR2+FR4) from leaves of both plants including standard of care 2% minoxidil. Control mice were untreated. Animals were treated for 33 days by topical application on the back skin and changes in hair

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Mila, Danielle, Adriana Calderon, Austin T. Baldwin, et al. "Asymmetric Wnt Pathway Signaling Facilitates Stem Cell-Like Divisions via the Nonreceptor Tyrosine Kinase FRK-1 in Caenorhabditis elegans." Genetics 201, no. 3 (2015): 1047–60. http://dx.doi.org/10.1534/genetics.115.181412.

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Wang, Bin, Li Zhang, Jindong Li, Peiyan Hua, and Yan Zhang. "Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK)." Digestive Diseases and Sciences 65, no. 10 (2020): 2853–62. http://dx.doi.org/10.1007/s10620-019-06015-5.

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Creeden, Justin F., Khaled Alganem, Ali S. Imami, et al. "Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia." International Journal of Molecular Sciences 21, no. 22 (2020): 8823. http://dx.doi.org/10.3390/ijms21228823.

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Abstract:

Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase targeting have been unable to appreciably increase patient survival. This may be due, in part, to unchecked desmoplastic reactions to pancreatic tumors. Desmoplastic stroma enhances tumor development and progression while simultaneously restricting drug delivery to the tumor cells it protects. Emerging evidence indicates tha

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