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Academic literature on the topic 'FTCD'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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Journal articles on the topic "FTCD"

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Gao, Ya-sheng, and Elizabeth Sztul. "A Novel Interaction of the Golgi Complex with the Vimentin Intermediate Filament Cytoskeleton." Journal of Cell Biology 152, no. 5 (February 26, 2001): 877–94. http://dx.doi.org/10.1083/jcb.152.5.877.

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The integration of the vimentin intermediate filament (IF) cytoskeleton and cellular organelles in vivo is an incompletely understood process, and the identities of proteins participating in such events are largely unknown. Here, we show that the Golgi complex interacts with the vimentin IF cytoskeleton, and that the Golgi protein formiminotransferase cyclodeaminase (FTCD) participates in this interaction. We show that the peripherally associated Golgi protein FTCD binds directly to vimentin subunits and to polymerized vimentin filaments in vivo and in vitro. Expression of FTCD in cultured cells results in the formation of extensive FTCD-containing fibers originating from the Golgi region, and is paralleled by a dramatic rearrangements of the vimentin IF cytoskeleton in a coordinate process in which vimentin filaments and FTCD integrate into chimeric fibers. Formation of the FTCD fibers is obligatorily coupled to vimentin assembly and does not occur in vim−/− cells. The FTCD-mediated regulation of vimentin IF is not a secondary effect of changes in the microtubule or the actin cytoskeletons, since those cytoskeletal systems appear unaffected by FTCD expression. The assembly of the FTCD/vimentin fibers causes a coordinate change in the structure of the Golgi complex and results in Golgi fragmentation into individual elements that are tethered to the FTCD/vimentin fibers. The observed interaction of Golgi elements with vimentin filaments and the ability of FTCD to specifically interacts with both Golgi membrane and vimentin filaments and promote their association suggest that FTCD might be a candidate protein integrating the Golgi compartment with the IF cytoskeleton.

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Lagopoulos, Jim, Gin S. Malhi, Belinda Ivanovski, Catherine M. Cahill, Erhard W. Lang, Yugan Mudaliar, Nick Dorsch, Alan Yam, Jane Griffith, and Jamin Mulvey. "Cerebrovascular autoregulation as a neuroimaging tool." Acta Neuropsychiatrica 18, no. 2 (April 2006): 100–104. http://dx.doi.org/10.1111/j.1601-5215.2006.00133.x.

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Functional transcranial Doppler (fTCD) sonography provides a high temporal resolution measure of blood flow and has over the years proved to be a valuable tool in the clinical evaluation of patients with cerebrovascular disorders. More recently, due to advances in physics and computing, it has become possible to derive indices of cerebrovascular autoregulation (CA) as well as cerebrovascular pressure reactivity (CR), using non-invasive techniques. These indices provide a dynamic representation of the brain's regulatory blood flow mechanisms not only in pathological states but also in health. However, whilst the temporal resolution of these regulatory indices is very good, spatially, the localization of brain regions remains very poor, thus limiting its brain mapping capacity. Functional MRI, on the contrary, is a brain-imaging technique that operates on similar blood flow principles; however, unlike fTCD, it provides high spatial resolution. Because both fTCD and fMRI determine blood flow-dependant imaging parameters, the coupling of fTCD with fMRI may provide greater insight into brain function by virtue of the combined enhanced temporal and spatial resolution that each technique affords. This review summarizes the fTCD technique with particular emphasis on the CA and CR indices and their relationship in traumatic brain injury as well as in health.

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Hayashi, Seiju, Tomoyuki Nakasa, Masakazu Ishikawa, Atsuo Nakamae, Shigeru Miyaki, and Nobuo Adachi. "Histological Evaluation of Early-Phase Changes in the Osteochondral Unit After Microfracture in a Full-Thickness Cartilage Defect Rat Model." American Journal of Sports Medicine 46, no. 12 (August 1, 2018): 3032–39. http://dx.doi.org/10.1177/0363546518787287.

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Background: The microfracture (MF) technique is an established surgical treatment for cartilage injury. However, the early-phase histological changes in full-thickness cartilage defects (FTCDs) after MF and the concomitant changes in the subchondral bone are still unknown. Purpose: To determine the early-phase histological changes in FTCD associated with subchondral bone remodeling after MF in rat model. Study Design: Controlled laboratory study. Methods: Rats were subjected to FTCD, followed by MF at the trochlear groove. For histological analysis, experiment and untreated control rats were sacrificed at 0, 1, 3, 7, 14, 28, and 56 days postoperatively (n = 6 knees per time point). Cartilage healing response was evaluated with the Pineda score. Osteoclast activity was evaluated by counting and locating the number of tartrate-resistant acid phosphatase (TRAP)–positive cells in the subchondral bone. MF hole diameter and bone mineral density in the subchondral bone were measured sequentially in 3 rats (n = 6 knees) by 3-dimensional μ–computed tomography. Results: Pineda score showed no difference in cartilage response from day 0 to day 3 but a significant improvement from day 7 to day 56. Although the MF holes were filled with blood clots in all specimens, the defect sites were not. The number of TRAP-positive cells peaked at day 3, mostly accumulating around the deeper zone of the MF holes. Over time, the number of TRAP-positive cells decreased to preoperative levels, localizing around the aperture of the MF holes where there was active remodeling of the osteochondral unit. The MF hole diameter was largest at day 14, and most holes disappeared by day 28. Bone mineral density was also highest at day 14 and decreased to preoperative levels by day 56. Conclusion: Histological changes in the FTCD after MF were derived from endochondral ossification within the deeper zone of the MF holes. Clinical Relevance: The absence of healing by blood clot in the FTCD should be noted by surgeons performing MF, and indications for MF should be carefully considered not only for maximizing the postoperative clinical outcome but also minimizing potential complications, such as formation of subchondral bone cysts or intralesional osteophytes.

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Mikadze, Yu V., M. D. Bogdanova, E. S. Lysenko, A. R. Shakhnovich, and S. M. Abuzaid. "Assessment of hemodynamic cerebral lateralization during the performance of verbal mnestic tasks with the use of functional transcranial doppler ultrasound." Experimental Psychology (Russia) 8, no. 3 (2015): 62–73. http://dx.doi.org/10.17759/exppsy.2015080306.

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There are the preliminary results of the research of interhemispheric asymmetry of cerebral hemodynamics during the performance of auditory-verbal and visual memory tasks with the use of functional transcranial doppler ultrasound (fTCD). The fTCD is considered as a non-invasive and objective method for assessment the dominant hemisphere for verbal functions. The aim of two experiments was to analyze the effect of a) different types of verbal and nonverbal tasks and b) the conditions of the mnestic activity performance (memorize and recognize) on the changes of blood flow velocity in left and right hemispheres in 62 healthy subjects. There are preliminary results of possible application fTCD to identify the dominant hemisphere for speech functions with combination of concrete verbal cognitive tasks and condition of its presentation.

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Schuepbach, D., S. Egger, and S. C. Herpertz. "Cerebral hemodynamics in schizophrenia during the Trail Making Test: A functional transcranial Doppler sonography study." European Psychiatry 33, S1 (March 2016): S107. http://dx.doi.org/10.1016/j.eurpsy.2016.01.094.

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IntroductionSchizophrenia is a severe mental disorder, with complex symptoms involving psychosis, negative symptoms and cognitive impairment. The Trail Making Test (TMT) has been widely used to assess attention and executive function. Functional transcranial Doppler sonography (fTCD) of basal cerebral arteries allows monitoring of aberrant cerebral hemodynamics during cognitive tasks in this patient group.ObjectivesWe assessed cerebral hemodynamics in the middle cerebral arteries (MCA) using fTCD while patients with schizophrenia and healthy subjects performed the TMT and a control task.MethodsFifteen patients with chronic schizophrenia and 15 healthy controls performed the TMT-A and -B during fTCD measurements of the MCA. Dependent measures were performance, mean cerebral blood flow velocity (MFV) and the lateralization.ResultsPatients demonstrated an overall decreased speed of solution (P = 0.002), and there was no significant effect of age. They showed a significantly increased flow pattern for the TMT-B (P = 0.005). There were no lateralization differences between diagnostic groups.ConclusionsThere was a performance deficit in patients with schizophrenia for both TMT-A and -B that fits well with results of existing literature. The aberrant hemodynamic response supports the idea that cognitive performance elicits an aberrant cerebral hemodynamic correlate. It adds to the notion that fTCD is a valuable tool to correlate psychological paradigms with brain perfusion in patients with schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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WHITEHOUSE, ANDREW J. O., NICHOLAS BADCOCK, MARGRIET A. GROEN, and DOROTHY V. M. BISHOP. "Reliability of a novel paradigm for determining hemispheric lateralization of visuospatial function." Journal of the International Neuropsychological Society 15, no. 6 (November 2009): 1028–32. http://dx.doi.org/10.1017/s1355617709990555.

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AbstractIn most individuals, language production and visuospatial skills are subserved predominantly by the left and right hemispheres, respectively. Functional Transcranial Doppler (fTCD) provides a noninvasive and relatively low-cost method for measuring functional lateralization. However, while the silent word generation task provides an accurate and reliable paradigm for investigating lateralization of language production, there is no comparable gold-standard method for measuring visuospatial skills. Thirty undergraduate students (19 females) completed a task of spatial memory while undergoing fTCD recording. Participants completed this task at two different time points, separated by between 26 to 155 days. The relative activation between hemispheres averaged across all participants was found to be consistent across testing sessions. This was observed at the individual level also, with a quantitative index of lateralization showing high reproducibility. These findings indicate that the use of the spatial memory task with fTCD is a robust methodology for examining laterality of visuospatial skills. (JINS, 2009, 15, 1028–1032.)

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Piper, Megan E., Timothy B. Baker, Neal L. Benowitz, Stevens S. Smith, and Douglas E. Jorenby. "E-cigarette Dependence Measures in Dual Users: Reliability and Relations With Dependence Criteria and E-cigarette Cessation." Nicotine & Tobacco Research 22, no. 5 (March 15, 2019): 756–63. http://dx.doi.org/10.1093/ntr/ntz040.

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Abstract Background Electronic cigarettes (e-cigarettes) have drastically changed the nicotine and tobacco product landscape. However, their potential public health impact is still unclear. A reliable and valid measure of e-cigarette dependence would likely advance assessment and prognostication of the public health impact of e-cigarettes. The aim of this research was to examine the internal consistency, structure, and validity of three e-cigarette dependence scales. Methods Adult dual users (smokers who also vape, N = 256) enrolled in an observational cohort study (45.1% women, 70.7% white). At baseline, participants completed the e-cigarette Fagerström Test of Cigarette Dependence (e-FTCD), the e-cigarette Wisconsin Inventory of Smoking Dependence Motives (e-WISDM), and the Penn State Electronic Cigarette Dependence Index (PS-ECDI). All participants provided a urine sample for cotinine analysis and reported e-cigarette use at 1 year. Results The e-WISDM subscales had the highest internal consistency (α = .81–.96), then the PS-ECDI (α = .74) and e-FTCD (α = .51). A single-factor structure for the e-FTCD and an 11-factor structure for the e-WISDM were supported, but the PS-ECDI did not have a single-factor structure. All three e-cigarette dependence scales were highly correlated with validation criteria including continued e-cigarette use at 1 year, but not with e-liquid nicotine concentration or cotinine. Conclusions The e-WISDM and PS-ECDI had stronger internal consistency than did the e-FTCD, despite the e-FTCD’s single-factor structure, but all 3 measures appear to be valid measures of e-cigarette dependence as suggested by their significant relations with self-perceived addiction, heavy use, early use after overnight deprivation, and continued use over time. Implications This research provides empirical support for three e-cigarette dependence measures: the e-FTCD, the PS-ECDI, and the e-WISDM among dual users of e-cigarettes and combustible cigarettes. The PS-ECDI and e-WISDM are more reliable, but all three measures were strongly correlated with key dependence constructs such as heavy use and continued use over time.

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Zhang, Wenfeng, Chaoying Wu, Rui Ni, Qifen Yang, Lingfei Luo, and Jianbo He. "Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1." PLOS Genetics 17, no. 12 (December 23, 2021): e1009980. http://dx.doi.org/10.1371/journal.pgen.1009980.

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The liver is a crucial center in the regulation of energy homeostasis under starvation. Although downregulation of mammalian target of rapamycin complex 1 (mTORC1) has been reported to play pivotal roles in the starvation responses, the underpinning mechanisms in particular upstream factors that downregulate mTORC1 remain largely unknown. To identify genetic variants that cause liver energy disorders during starvation, we conduct a zebrafish forward genetic screen. We identify a liver hulk (lvh) mutant with normal liver under feeding, but exhibiting liver hypertrophy under fasting. The hepatomegaly in lvh is caused by enlarged hepatocyte size and leads to liver dysfunction as well as limited tolerance to starvation. Positional cloning reveals that lvh phenotypes are caused by mutation in the ftcd gene, which encodes the formimidoyltransferase cyclodeaminase (FTCD). Further studies show that in response to starvation, the phosphorylated ribosomal S6 protein (p-RS6), a downstream effector of mTORC1, becomes downregulated in the wild-type liver, but remains at high level in lvh. Inhibition of mTORC1 by rapamycin rescues the hepatomegaly and liver dysfunction of lvh. Thus, we characterize the roles of FTCD in starvation response, which acts as an important upstream factor to downregulate mTORC1, thus preventing liver hypertrophy and dysfunction.

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Woodhead, Zoe V. J., Holly A. Rutherford, and Dorothy V. M. Bishop. "Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks." Wellcome Open Research 3 (August 24, 2018): 104. http://dx.doi.org/10.12688/wellcomeopenres.14720.1.

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Background: Relative blood flow in the two middle cerebral arteries can be measured using functional transcranial Doppler sonography (fTCD) to give an index of lateralisation as participants perform a specific task. Language laterality has mostly been studied with fTCD using a word generation task, but it is not clear whether this is optimal. Methods: Using fTCD, we evaluated a sentence generation task that has shown good reliability and strong left lateralisation in fMRI. We interleaved trials of word generation, sentence generation and list generation and assessed agreement of these tasks in 31 participants (29 right-handers). Results: Although word generation and sentence generation both gave robust left-lateralisation, Bland-Altman analysis showed that these two methods were not equivalent. The comparison list generation task was not systematically lateralised, but nevertheless laterality indices (LIs) from this task were significantly correlated with the other two tasks. Subtracting list generation LI from sentence generation LI did not affect the strength of the laterality index. Conclusions: This was a pre-registered methodological study designed to explore novel approaches to optimising measurement of language lateralisation using fTCD. It confirmed that sentence generation gives robust left lateralisation in most people, but is not equivalent to the classic word generation task. Although list generation does not show left-lateralisation at the group level, the LI on this task was correlated with left-lateralised tasks. This suggests that word and sentence generation involve adding a constant directional bias to an underlying continuum of laterality that is reliable in individuals but not biased in either direction. In future research we suggest that consistency of laterality across tasks might have more functional significance than strength or direction of laterality on any one task.

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Woodhead, Zoe V. J., Holly A. Rutherford, and Dorothy V. M. Bishop. "Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks." Wellcome Open Research 3 (October 15, 2018): 104. http://dx.doi.org/10.12688/wellcomeopenres.14720.2.

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Background: Relative blood flow in the two middle cerebral arteries can be measured using functional transcranial Doppler sonography (fTCD) to give an index of lateralisation as participants perform a specific task. Language laterality has mostly been studied with fTCD using a word generation task, but it is not clear whether this is optimal. Methods: Using fTCD, we evaluated a sentence generation task that has shown good reliability and strong left lateralisation in fMRI. We interleaved trials of word generation, sentence generation and list generation and assessed agreement of these tasks in 31 participants (29 right-handers). Results: Although word generation and sentence generation both gave robust left-lateralisation, Bland-Altman analysis showed that these two methods were not equivalent. The comparison list generation task was not systematically lateralised, but nevertheless laterality indices (LIs) from this task were significantly correlated with the other two tasks. Subtracting list generation LI from sentence generation LI did not affect the strength of the laterality index. Conclusions: This was a pre-registered methodological study designed to explore novel approaches to optimising measurement of language lateralisation using fTCD. It confirmed that sentence generation gives robust left lateralisation in most people, but is not equivalent to the classic word generation task. Although list generation does not show left-lateralisation at the group level, the LI on this task was correlated with left-lateralised tasks. This suggests that word and sentence generation involve adding a constant directional bias to an underlying continuum of laterality that is reliable in individuals but not biased in either direction. In future research we suggest that consistency of laterality across tasks might have more functional significance than strength or direction of laterality on any one task.

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Dissertations / Theses on the topic "FTCD"

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Rösler, Julia [Verfasser], and Hajo M. [Akademischer Betreuer] Hamer. "Sprachdominanz und Verbalgedächtnis bei Patienten mit rezidivierender depressiver Erkrankung : eine Studie mittels funktioneller transkranieller Dopplersonographie (fTCD) / Julia Rösler. Betreuer: Hajo M. Hamer." Marburg : Philipps-Universität Marburg, 2012. http://d-nb.info/1027183743/34.

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Flekal, Lukáš. "FTC řízení průmyslových robotů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229960.

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This diploma thesis presents theoretical possibilities of force/torque control algorithms for industrial robots equipped with force sensor so it deals with interaction between industrial robot and environment. The most important types of control schemes are presented. Practical part deals with design gripper for specific workpiece and for grinding using industrial robot with force feedback. For this operation is given force/torque control design, using industrial robot KUKA KR16, FTC sensor SCHUNK FTC 50-80V and PLC. Further deals with compensation of gravity and dynamics forces.

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Westlin, Johan, and Thomas Carlsson. "Analys ac konstruktionsprocessen inom FTC." Thesis, Uppsala universitet, Tillämpad kärnfysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202772.

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This thesis work was made to optimize the writing of the construction specifications at FKA. These construction specifications are created before each plant modifications that is started because requirements from the Swedish radiation safety authority (SSM) and internally on Forsmarks nuclear group as constructions / implementation documentation The study was done through seven interviews of two people at three different groups involved in the construction specification and an interview from the group accredited verification. The four selected groups were selected through an extensive analytical work resulted in an elimination matrix where these four groups was considered to be most involved with the construction specification. The questions asked to these individuals were based on the instructions and sample text that are described in the construction specification. To ensure the quality of the thesis were to limit itself to the chapters that were considered most relevant to improve. The analysis revealed a number of points that should be improved, partly into the routines when writing the construction specification and when ether sample text or suggestions should be changed and complemented. Some of the most interesting results where that there are some relatively simple improvements that can be implemented with a small amount of work. Some of those results where an implementation of a table for the radiation in a specific room as well as using an excel file where all people involved in the construction specification can make suggestions for the updated version of the operating instructions. Other improvements are more complicated to implement as they are soft issues like a continuous improvement of the communication between different groups at FKA

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Ratti, Elena. "Longitudinal Characterization of the FTD-ALS Spectrum." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17613739.

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Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are heterogeneous neurodegenerative diseases that, despite presenting divergent clinical features, can occur within the same person. Based on shared genetics and pathology, characterizing FTD-ALS with clinical and quantitative imaging measures over time may highlight patterns of disease progression and specific brain system vulnerabilities, leading to needed biomarkers development. We propose to build, characterize and compare concurrent FTD-ALS, ALS and FTD cohorts with a prospective observational cohort study performed at Massachusetts General Hospital, including clinical and MRI based imaging measures specific to both ALS and FTD. We will perform quantitative cortical thickness and sub-cortical structures analysis, white matter anatomical and functional integrity evaluations, correlations between anatomical and clinical measures, both within patient and inter-patient populations. To date, there are no longitudinal studies or quantitative cortical thickness evaluations across the entire FTD-ALS continuum. Our longitudinal comprehensive and specialized assessments will lead to the development of a unique dataset evaluating the full FTD-ALS spectrum with standardized measures in a multidisciplinary approach. This will provide the basis for further FTD-ALS research and it will contribute to the development of quantitative biomarkers of disease and disease progression across clinically heterogeneous diseases, impacting both clinical and research practices.

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Schwenk, Benjamin. "The FTLD risk factor TMEM106B controls lysosomal trafficking and dendrite outgrowth." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-181956.

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Frontotemporal dementia is the second most common neurodegenerative disease in people younger than 65 years. Patients suffer from behavioral changes, language deficits and speech impairment. Unfortunately, there is no effective treatment available at the moment. Cytoplasmic inclusions of the DNA/RNA-binding protein TDP-43 are the pathological hallmark in the majority of FTLD cases, which are accordingly classified as FTLD-TDP. Mutations in GRN, the gene coding for the trophic factor progranulin, are responsible for the majority of familiar FTLD-TDP cases. The first genome-wide association study performed for FTLD-TDP led to the identification of risk variants in the so far uncharacterized gene TMEM106B. Initial cell culture studies revealed intracellular localization of TMEM106B protein in lysosomes but its neuronal function remained elusive. Based on these initial findings, I investigated the physiological function of TMEM106B in primary rat neurons during this thesis. I demonstrated that endogenous TMEM106B is localized to late endosomes and lysosomes in primary neurons, too. Notably, knockdown of the protein does neither impair general neuronal viability nor the protein level of FTLD associated proteins, such as GRN or TDP-43. However, shRNA-mediated knockdown of TMEM106B led to a pronounced withering of the dendritic arbor in developing and mature neurons. Moreover, the strong impairment of dendrite outgrowth and maintenance was accompanied by morphological changes and loss of dendritic spines. To gain mechanistic insight into the loss-of-function phenotypes, I searched for coimmunoprecipitating proteins by LC-MS/MS. I specifically identified the microtubule-binding protein MAP6 as interaction partner and was able to validate binding. Strikingly, overexpression of MAP6 in primary neurons phenocopied the TMEM106B knockdown effect on dendrites and loss of MAP6 restored dendritic branching in TMEM106B knockdown neurons, indicating functional interaction of the two proteins. The link between a lysosomal and a microtubule-binding protein made me study the microtubule dependent transport of dendritic lysosomes. Remarkably, live cell imaging studies revealed enhanced movement of dendritic lysosomes towards the soma in neurons devoid of TMEM106B. Again, MAP6 overexpression phenocopied and MAP6 knockdown rescued this effect, strengthening the functional link. The MAP6-independent rescue of dendrite outgrowth by enhancing anterograde lysosomal movement provided additional evidence that dendritic arborization is directly controlled by lysosomal trafficking. From these findings I suggest the following model: TMEM106B and MAP6 together act as a molecular brake for the retrograde transport of dendritic lysosomes. Knockdown of TMEM106B and (the presumably dominant negative) overexpression of MAP6 release this brake and enhance the retrograde movement of lysosomes. Subsequently, the higher protein turnover and the net loss of membranes in distal dendrites may cause the defect in dendrite outgrowth. The findings of this study suggest that lysosomal misrouting in TMEM106B risk allele carrier might further aggravate lysosomal dysfunction seen in patients harboring GRN mutations and thereby contribute to disease progression. Taken together, I discovered the first neuronal function for the FTLD-TDP risk factor TMEM106B: This lysosomal protein acts together with its novel, microtubule-associated binding partner MAP6 as molecular brake for the dendritic transport of lysosomes and thereby controls dendrite growth and maintenance.
Frontotemporale Demenz ist die zweithäufigste Form neurodegenerativer Erkrankungen bei Menschen unter 65 Jahren. Patienten leiden an Verhaltensauffälligkeiten und Sprach- sowie Artikulationsstörungen. Leider steht zurzeit keine wirksame medikamentöse Therapie zur Verfügung. Das pathologische Hauptmerkmal der meisten FTLD-Fälle sind zytoplasmatische Einschlüsse des DNA/RNA-bindenden Proteins TDP-43. Diese Fälle werden entsprechend als FTLD-TDP klassifiziert. Für einen Großteil der familiären FTLD-TDP Fälle sind Mutationen in GRN, dem für den Wachstumsfaktor Progranulin kodierenden Gen, verantwortlich. Die erste für FTLD-TDP durchgeführte genomweite Assoziationsstudie führte zur Entdeckung von genetischen Varianten im bis dato uncharakterisierten Gen TMEM106B. Diese Varianten sind mit einem erhöten Risiko an FTLD zu erkranken assoziiert. Initiale Studien in Zellkultur zeigten eine Lokalisierung des TMEM106B Proteins in Lysosomen, die Frage nach der neuronale Funktion des Proteins blieb allerdings bisher unbeantwortet. Auf diesen ersten Ergebnissen aufbauend untersuchte ich während meiner Dissertation die physiologische Funktion von TMEM106B in primären Ratten-neuronen. Ich konnte zeigen, dass endogenes TMEM106B auch in primären Neuronen in späten Endsosomen und Lysosomen lokalisiert ist. Beachtenswerterweise verminderte die Herunterregulierung (shRNA-vermittelter Gen-Knockdown) des Proteins weder das generelle Überleben der Neuronen noch die Level von anderen FTLD-assoziierten Proteinen, wie GRN oder TDP-43. Die Herunterregulierung von TMEM106B führte jedoch zu einem ausgeprägten Verlust von Dendriten in sich entwickelnden und ausgereiften Neuronen. Des Weiteren war die starke Beeinträchtigung dendritischen Wachstums und Aufrechterhaltung von einer morphologischen Veränderung und dem Verlust der Dornfortsätze begleitet. Um den Mechanismus dieser Phänotypen zu erklären, suchte ich nach TMEM106B coimmunopräzipitierenden Proteinen mittels Massenspektrometrie. Ich konnte das Mikrotubuli bindende Protein MAP6 als spezifischen Bindungspartner identifizieren und die Interaktion beider Proteine validieren. Hervorzuheben ist, dass die Überexpression von MAP6 in primären Neuronen den Effekt der Herunterregulation von TMEM106B auf die Dendriten kopierte und die Herunterregulation von MAP6 die dendritischen Verästelungen in TMEM106B depletierten Neuronen sogar wiederherstellen konnte. Diese Ergebnisse legen eine funktionelle Interaktion beider Proteine nahe. Die Verbindung zwischen einem lysosomalen und einem an die Mikrotubuli bindenden Protein brachte mich dazu, den Mikrotubuli abhängigen Transport von dendritischen Lysosomen zu untersuchen. Bemerkenswerterweise zeigten mittels Lebendzellmikroskopie erzeugte Aufnahmen eine erhöhte Bewegung dendritischer Lysosomen Richtung Zellsoma in TMEM106B depletierten Neuronen. Auch in diesem Kontext konnte die Überexpression von MAP6 den Effekt kopieren und die Herunterregulation von MAP6 den Effekt aufheben und somit die These einer funktionellen Interaktion festigen. Die MAP6 unabhängige Wiederherstellung des dendritischen Wachstums durch die Erhöhung des lysosomalen Transports in anterograder Richtung lieferte einen zusätzlichen Beweis dafür, dass das dendritische Wachstum direkt von lysosomalem Transport abhängt. Ausgehend von diesen Ergebnissen schlage ich folgendes Modell vor: TMEM106B und MAP6 wirken zusammen als molekulare Bremse für den retrograden Transport dendritischer Lysosomen. Die Herunterregulation von TMEM106B und die (wahrscheinlich dominant negative wirkende) Überexpression von MAP6 lösen diese Bremse und verstärken die retrograde Bewegung von Lysosomen. Daraufhin könnten der gestiegene Proteinumsatz und der Verlust von Plasmamembranbestandteilen zu einem Fehler im dendritischen Wachstum führen. Die Ergebnisse dieser Arbeit legen nahe, dass fehlerhafter, lysosomaler Transport in TMEM106B Risikoallelträgern zu einer Verstärkung der lysosomalen Fehlfunktion in Patienten mit GRN Mutation führt und dabei zur Krankheitsentwicklung beiträgt. Zusammengefasst habe ich die erste neuronale Funktion für den FTLD-TDP Risikofaktor TMEM106B entdeckt: Dieses lysosomale Protein wirkt zusammen mit seinem neuentdeckten, Mikrotubuli assoziierten Bindungspartner MAP6 als molekulare Bremse für den dendritischen Transport von Lysosomen und kontrolliert dadurch Wachstum und Aufrechterhaltung von Dendriten.

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Hu, Quan. "The molecular pathology, genetic involvement and biochemical characteristics of fused in sarcoma (FUS) protein and chromosome 9p-linked frontotemporal lobar degeneration." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-molecular-pathology-genetic-involvement-and-biochemical-characteristics-of-fused-in-sarcoma-fus-protein-and-chromosome-9plinked-frontotemporal-lobar-degeneration(4ac87100-f73a-41c9-a921-f6af5d54dd27).html.

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The fused in sarcoma (FUS) protein has been shown to be a significant disease protein in a subgroup of patients with frontotemporal lobar degeneration (FTLD). Nevertheless, the mechanism underlying FUS associated FTLD is only poorly understood. Recent research has identified a large hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72), reinforcing the association between C9orf72 and FTLD. Moreover, an unusual histopathological change has been observed within the granule cell layer of the cerebellum in chromosome 9p-linked frontotemporal dementia with motor neuron disease. Whether this type of cerebellar pathology is a pathological marker for chromosome 9p-linked families remains unknown. The purpose of this study was to genetically, neuropathologically and biochemically characterize FUS and C9orf72 in FTLD, and also to investigate the association between the cerebellar pathology and chromosome 9p-linked families. The genetic sequencing study searching for potential genetic factors of FUS in FTLD failed to detect any pathogenic mutations or variations. Immunohistochemical study for FUS pathology in FTLD provided strong evidence for FUS being the specific pathological protein in all forms of FTLD-FUS. Immunoblotting for FUS in FTLD detected one novel disease-associated FUS aggregate (~37 kDa) in the urea fraction of atypical FTLD with ubiquitinated inclusions (aFTLD-U) frontal cortical samples, suggesting this unique protein product might be more associated with disease than the full-length protein itself. Immunohistochemical study of C9orf72 in FTLD detected a 'synaptic' staining in CA sectors, as the most prominent histological feature identified. Immunoblotting for C9orf72 protein demonstrated no distinctive bands among different diagnostic groups, in frontal and cerebellar cortical regions. The present study also confirmed the presence of cerebellar p62 neuronal cytoplasmic inclusions (NCI) in a proportion of FTLD-TDP cases. Although most of these cases showed an autosomally dominant pattern of inheritance, not all of them shared a common C9orf72 haplotype, or mutation in C9orf72.Much work is still needed to investigate the underlying pathogenesis of FTLD-FUS. Attention should still be given to identifying possible genetic risk factors in FUS using a large series of FTLD samples and searching for other possible proteins within the FUS immunoreactive neuronal inclusions. Moreover, the target protein within the cerebellar p62 NCI remains unknown, but it is clear that it is not C9orf72 protein.

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Licata, Nausicaa Valentina. "Identification of new pathways modulating C9orf72-derived DPRs expression." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276572.

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The hexanucleotide repeat expansion GGGGCCn (also known as G4C2n) localizes in the first intron of the C9ORF72 gene and is the most common genetic cause of ALS and FTD (C9ALS/FTD). The pathomechanisms proposed for C9ALS/FTD suggest that from sense (G4C2)n- and anti-sense (C4G2)n-containing transcripts originate two different mechanisms of toxicity: i) by the alteration of RNA processing due to binding and sequestration of RNA-binding proteins, thereby leading to impairment of RNA metabolism; and ii) by their unconventional Repeat-associated non AUG (RAN) translation into five different dipeptide-repeats (DPRs). In addition, pathological expansion of (G4C2)n reduces the C9orf72 transcription causing loss of function of the C9ORF72 protein. The toxicity of some of these DPRs has been showed in several cell lines, in iPSC-derived neurons, in Drosophila and in mouse models. An impairment of the ubiquitin-proteasome system (UPS) due to aggregation of toxic proteins is largely demonstrated in neurodegenerative disorders and among the mechanisms of DPR-related toxicity. RAN translation of (G4C2)n-RNAs has been recently shown to require a near-cognate start codon upstream of the repeat in frame +1 and to be triggered by stress conditions in a cap-dependent or cap-independent way. However, the mechanism regulating RAN translation is still largely unknown. Importantly, no small molecules are known to selectively modulate RAN translation, even if antisense oligonucleotides (ASOs) and small molecules binding the r(GGGGCC)n have been proposed as therapeutics for C9ALS/FTD. In addition, no effective pharmacological approach to reduce the pathological load of DPRs is currently available. Here, I developed a high-throughput drug-screening assay to identify small molecules and relative molecular targets that can modulate the DPR level. Among the identified hits, two hits reduced DPRs expression levels triggering the protein clearance system in vitro. Moreover, the screening identified compounds having the same target that increased DPRs expression levels indicating the targeted pathway as a crucial modulator of the translation process of the C9orf72 repeat-containing mRNAs. Conversely, I showed that pharmacological inhibition of the pathway reduced DPRs expression levels in vitro, while in vivo it rescued climbing ability and increased life span of Drosophila flies carrying G4C2X36 repeats. Moreover, genetic ablation of the target reduced DPRs expression levels by decreasing their translation efficiency in vitro and rescued the pathological phenotype in vivo. Together, the results show the identification of new pathways as new drug targets for C9ALS/FTD.

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Mimochodek, Martin. "FTC řízení průmyslových robotů a jeho aplikace v oblasti broušení." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229176.

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This diploma thesis deals with a conception of force-torque control of industrial robot applied on a finishing technology of grinding. This work includes a classification of various force-torque sensors currently available on the market. The practical part of this thesis deals with a setting-up of communication and connection among the force-torque sensor SCHUNK FTC 050-80, PLC Beckhoff CX and industrial robot KUKA KR3. Practical part is further focused on a simple model of grinding, especially the grinding force control in relation to the robot movement.

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Mueller, Julius [Verfasser], Armin [Forscher] Küllmer, Arthur [Sonstige] Schmidt, Robert [Sonstige] Thimme, Dominik [Sonstige] Bettinger, Hannes Philipp [Sonstige] Neeff, and Arthur [Akademischer Betreuer] Schmidt. "Effektivität und Sicherheit bei der endoskopischen Vollwandresektion von Adenokarzinomen mit dem FTRD® - System." Freiburg : Universität, 2020. http://d-nb.info/1211326772/34.

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Krampe, Stefan. "Nutzung von "Floating Traveller Data (FTD)" für mobile Lotsendienste im Verkehr." Darmstadt Techn. Univ, 2007. http://d-nb.info/996669663/34.

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Books on the topic "FTCD"

1

McCune, Sandra K. CliffsTestPrep FTCE. New York: John Wiley & Sons, Ltd., 2007.

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Kaplan, Jeffrey S. CliffsTestPrep FTCE. New York: John Wiley & Sons, Ltd., 2005.

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FTCE: General knowledge. Boston: XAMonline, Inc., 2015.

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FTCE general knowledge. 3rd ed. Boston: XAMonline, Inc., 2010.

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Association, Research and Education, ed. FTCE: General knowledge. 2nd ed. Piscataway, N.J: Research & Education Assoc., 2011.

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FTCE general knowledge. 5th ed. Boston: XAMonline, Inc., 2014.

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FTCE Chemistry 6-12. Cambridge: XAMonline, 2009.

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FTCE Physics 6-12. Cambridge: XAMonline, 2009.

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Cain, Alexander Vi, ed. FTCE: Professional education test. Hoboken, NJ: Wiley Pub., 2007.

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Ann, Tattner Nancy, Green Betty Nielsen, and Research and Education Association, eds. FTCE elementary education K-6. 2nd ed. Piscataway, N.J: Research & Education Association, 2012.

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Book chapters on the topic "FTCD"

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Vadikolias, Konstantinos, and Georgios Tsivgoulis. "Applications of Functional Transcranial Doppler (fTCD)." In Cerebrovascular Ultrasound in Stroke Prevention and Treatment, 177–86. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444327373.ch9.

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Khalaf, Aya, Ervin Sejdic, and Murat Akcakaya. "Hybrid EEG–fTCD Brain–Computer Interfaces." In Neuroergonomics, 295–314. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-34784-0_15.

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Desnick, Robert J., Orlando Guntinas-Lichius, George W. Padberg, Gustav Schonfeld, Xiaobo Lin, Maurizio Averna, Pin Yue, et al. "FTD." In Encyclopedia of Molecular Mechanisms of Disease, 675. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8311.

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Madsen, Tanja. "Die Medienmarke FTD." In Erfolgreiche Führung von Medienmarken, 129–42. Wiesbaden: Gabler Verlag, 2004. http://dx.doi.org/10.1007/978-3-663-08025-1_7.

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Imam, Ibrahim. "Frontotemporal dementia (FTD)." In 700 Essential Neurology Checklists, 12–13. New York: CRC Press, 2021. http://dx.doi.org/10.1201/9781003221258-6.

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Bertoux, Maxime, Claire O’Callaghan, Emma Flanagan, and Michael Hornberger. "Frontotemporal Dementia (FTD)." In Encyclopedia of Geropsychology, 1–17. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-287-080-3_311-1.

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Bertoux, Maxime, Claire O’Callaghan, Emma Flanagan, and Michael Hornberger. "Frontotemporal Dementia (FTD)." In Encyclopedia of Geropsychology, 917–33. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-287-082-7_311.

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Luo, Hao. "Basics of FTC Structure." In Plug-and-Play Monitoring and Performance Optimization for Industrial Automation Processes, 25–39. Wiesbaden: Springer Fachmedien Wiesbaden, 2016. http://dx.doi.org/10.1007/978-3-658-15928-3_3.

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Maciejowski, J., and J. M. Lemos. "Predictive Methods for FTC." In Control of Complex Systems, 229–40. London: Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-0349-3_11.

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Elamin, Marwa, Taha Omer, Siobhan Hutchinson, Colin P. Doherty, and Thomas H. Bak. "Fronto-Temporal Dementia (FTD)." In Neurodegenerative Disorders, 117–43. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23309-3_7.

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Conference papers on the topic "FTCD"

1

Khalaf, Aya, Matthew Sybeldon, Ervin Sejdic, and Murat Akcakaya. "An EEG and fTCD based BCI for control." In 2016 50th Asilomar Conference on Signals, Systems and Computers. IEEE, 2016. http://dx.doi.org/10.1109/acssc.2016.7869581.

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Krishna, Athul, Adithya K. Moorthy, and R. G. Gayathri. "Heuristic Based Ex-FTCD Algorithm for Incremental Path Finding in Dynamic Graphs." In 2018 International Conference on Data Science and Engineering (ICDSE). IEEE, 2018. http://dx.doi.org/10.1109/icdse.2018.8527805.

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Khalaf, Aya, Ervin Sejdic, and Murat Akcakaya. "Mutual Information for Transfer Learning in SSVEP Hybrid EEG-fTCD Brain-Computer Interfaces." In 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2019. http://dx.doi.org/10.1109/ner.2019.8717018.

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Dagois, Elise, Aya Khalaf, Ervin Sejdic, and Murat Akcakaya. "Bhattacharyya Distance-based Transfer Learning for a Hybrid EEG-FTCD Brain-computer Interface." In ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). IEEE, 2019. http://dx.doi.org/10.1109/icassp.2019.8683308.

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Ali Hosseini, Seyed, and Karim Salahshoor. "A Q-Learning based Fault-Tolerant Controller with Application to CSTH System." In 7th International Conference on Software Engineering and Applications (SOFEA 2021). Academy and Industry Research Collaboration Center (AIRCC), 2021. http://dx.doi.org/10.5121/csit.2021.111605.

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Systems are continually subjected to faults or malfunctions because of age or sudden events, which might degrade the operation performance and even result in operation failure that is a quite important issue in safety-critical systems. Thus, this important problem is the main reason to use the Fault-Tolerant strategy to improve the system’s performance with the presence of faults. A fascinating property in Fault-Tolerant Controllers (FTCs) is adaptability to system changes as they evolve throughout system operations. In this paper, a Q-learning algorithm with a greedy policy was used to realize the FTC adaptability. Then, some fault scenarios are introduced in a Continuous Stirred Tank Heater (CSTH) to compare the closed-loop performance of the developed Q-learning-based FTC with concerning conventional PID controller and an RL-based FTC. The obtained results show the effectiveness of Q-learningbased FTC in different fault scenarios.

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Yi, Zhengming, Yiping Yao, and Kai Chen. "FTSD." In APSys '21: 12th ACM SIGOPS Asia-Pacific Workshop on Systems. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3476886.3477518.

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Liu, Ying, Lawrence T. Pileggi, and Andrzej J. Strojwas. "ftd." In the 35th annual conference. New York, New York, USA: ACM Press, 1998. http://dx.doi.org/10.1145/277044.277174.

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Peng, Nian, Tianshou Ma, Ping Chen, and Yu Qiao. "Effects of Near-Wellbore Supercharging and Hydro-Mechanical Coupling on Pressure Response for Formation Testing While Drilling." In 2022 SPWLA 63rd Annual Symposium. Society of Petrophysicists and Well Log Analysts, 2022. http://dx.doi.org/10.30632/spwla-2022-0088.

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Formation testing while drilling (FTWD) shows a great potential for characterizing reservoir type, estimating reserves, and determining reservoir energy. With the increasing in unconventional reservoirs, however, the utilization of FTWD has encountered some challenges. The near-wellbore formation prior to conducting the formation testing is usually supercharged due to the mud filtrate invasion during drilling. The supercharged pore pressure can directly influence the pressure response of FTWD. If the pressure response curves are misinterpreted, it may bring some mistakes or risks to engineering design. In addition, the formation testing process is a hydro-mechanical (H-M) coupling process, and the variation of pore pressure in formation can change the porosity and permeability of the rock, which will in turn affect the pressure response of formation testing while drilling. To clarify the effects of near-wellbore supercharging and H-M coupling on pressure response of FTWD, a three-dimensional simulation model of FTWD was built andthe pressure responses with different parameters wereanalyzed. The simulated results indicated that: In thesupercharged condition, the initial probe pressure ishigher than the original pore pressure. And during thepressure recovery stage, the probe pressure rises abovethe original formation pressure in the early part of thebuildup and then decreases to reach the equilibrium state.Also, the supercharging effect can result in theoverestimation of the original formation pressure. TheH-M coupling can produce an extra coupling skin on thepressure response of FTWD, and H-M coupling cancontribute to the underestimation of the originalformation mobility. The results of this paper can help usto understand the pressure response behavior andimprove the formation parameter interpretation accuracyof FTWD.

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Al-Dhaferi, Yousef, Anes Usman, Abdullah Al-Fawwaz, Rehab Al-Khalifah, and Ahmed Taher. "Reservoir Evaluation Utilizing Integrated Formation Pressure Testing while Drilling Along with Flow Testing Across Burgan Formation." In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210386-ms.

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Abstract Logging-While-Drilling (LWD) formation testers have been successfully used for years in measuring formation pressure and estimating formation mobility. In terms of applications, among many others, this data has been useful for mud weight optimization while drilling, reservoir fluid characterization, and selecting intervals for injectivity tests based on mobility variation. Recently, an LWD formation-pressure-testing-while-drilling (FTWD) tool was deployed in an onshore water-disposal injection well with minimal offset data. An intensive LWD program was utilized across the Burgan formation, including gamma ray, triple combo, multipole sonic, and FTWD, along with mud-logging and geomechanics services for pore-pressure prediction. Both LWD triple combo and surface logging data were used to confirm lithology for optimum pressure-point selection while drilling, prior to any wellbore damage, evaluating the reservoir for any potential compartmentalization and selection of potential water-injection zones. Due to an unfortunate wellbore collapse, flow testing was not an option to estimate the wellbore injectivity; therefore, the FTWD results were used to select where to drill a sidetrack lateral. The FTWD direct formation pressure and mobility measurements enriched the understanding of the reservoir by establishing pressure gradients. By interpreting the results of the selected points, reservoir zonation was estimated based on the calculated mobility, which indicated a high degree of permeability variation. Along with consistent formation-pressure measurements, the established water gradient from the measured FTWD pressure-test results while drilling were used as a baseline for comparison with FTWD pressure-test results repeated after a wiper trip. This comparison allowed the evaluation of pressure changes between the two runs and identification of time-lapse effects at the sand face. The challenging conditions in the drilled wellbore resulted in an unfortunate loss of the main borehole due to hole collapse across some shale intervals. As a result of losing the wellbore, it was not possible to obtain crucial reservoir flow-testing information. The FTWD interpreted data gave crucial insight, facilitating the decision on where to drill a sidetrack lateral that would meet the injectivity requirements. Based on the measured mobility, the sidetrack was drilled and tested for injectivity, yielding favorable results. This paper focuses on enhancing permeability estimation, along with fluid and mobility identification in clastic formations, utilizing an integrated approach of FTWD and injection testing for better formation evaluation and reservoir characterization. The integration of the LWD data with the water injectivity profile evaluation highlighted the importance of proper characterization of the mobility/permeability of the formation. This in turn provided clue to the observed variation in injection profile with time as shown by periodic PLT logging.

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Cazzaniga, R., Marco Rosa-Clot, Paolo Rosa-Clot, and Giuseppe M. Tina. "Floating tracking cooling concentrating (FTCC) systems." In 2012 IEEE 38th Photovoltaic Specialists Conference (PVSC). IEEE, 2012. http://dx.doi.org/10.1109/pvsc.2012.6317668.

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Reports on the topic "FTCD"

1

Leahy, Andrew. A Euclidean Approach to the FTC. Washington, DC: The MAA Mathematical Sciences Digital Library, September 2004. http://dx.doi.org/10.4169/loci002156.

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Schaff, Gerald G. The Discretionary Function Exception in FTCA Litigation Alleging Medical Malpractice. Fort Belvoir, VA: Defense Technical Information Center, April 1993. http://dx.doi.org/10.21236/ada264701.

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Skone, Timothy J. Fischer-Tropsch Diesel (FTD) Energy Conversion Facility Commissioning/Decommissioning. Office of Scientific and Technical Information (OSTI), February 2010. http://dx.doi.org/10.2172/1509378.

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