Relevant bibliographies by topics / FTL Associates

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'FTL Associates'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'FTL Associates.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "FTL Associates"

1

Sirasanagandla, Srinivasa, Varna Taranikanti, and Raghu Jetti. "A Complex Cross Link between the Tendons of Flexor Hallucis Longus and Flexor Digitorum Longus." Journal of Morphological Sciences 35, no. 03 (September 2018): 177–79. http://dx.doi.org/10.1055/s-0038-1675225.

Full text
Abstract:
AbstractAnatomical variations involving the flexor digitorum longus (FDL) and flexor hallucis longus (FHL) tendons are clinically important because of their significant role in reconstructive surgeries of tibialis posterior tendon insufficiencies and Achilles tendinopathies. Harvesting of grafts from these complex variations of FDL and FHL are surgically challenging. In the present case, we report a complex structural cross link between the FDL and FHL associated with morphological variations of the first lumbrical and flexor digitorum accessorius (FDA) attachments. A connecting slip from FHL was found to be inserted into the FDL tendon of the second toe. The FDA was inserted into the fibular side of the connecting slip of the FHL as well as into the FDL tendons of the third and fourth toes. The first lumbrical took origin from the tibial side of FHL connecting slip and from the tibial side of FDL tendon for second toe.
APA, Harvard, Vancouver, ISO, and other styles
2

Ali, Sayed, Nicole L. Griffin, Whitney Ellis, and Andrew J. Meyr. "Communication of Contrast in the Flexor Hallucis Longus Tendon with Other Pedal Tendons at the Master Knot of Henry." Journal of the American Podiatric Medical Association 107, no. 2 (March 1, 2017): 166–70. http://dx.doi.org/10.7547/14-148.

Full text
Abstract:
It is important to have a full appreciation of lower-extremity anatomical relationships before undertaking diabetic foot surgery. We sought to evaluate the potential for communication of the flexor hallucis longus (FHL) tendon with other pedal tendons and plantar foot compartments at the master knot of Henry and to provide cadaveric images and computed tomographic (CT) scans of such communications. Computed tomography and subsequent anatomical dissection were performed on embalmed cadaveric limbs. Initially, 5 to 10 mL (1:4 dilution) of iohexol and normal saline was injected into the FHL sheath as it coursed between the two hallux sesamoids. Subsequently, CT scans were obtained in the axial plane using a multidetector CT scanner with sagittal and coronal reformatted images. The limbs were then dissected for specific evaluation of the known variable intertendinous connections between the FHL and flexor digitorum longus (FDL) and quadratus plantae (QP) muscles. One cadaver demonstrated retrograde flow of contrast into the four individual tendons of the FDL, with observation of a large intertendinous slip between the FHL and FDL on dissection. Another cadaver demonstrated contrast filling in the QP with an associated intertendinous slip between the FHL and QP on dissection. These results indicate that the master knot of Henry (the location in the plantar aspect of the midfoot where the FHL and FDL tendons decussate, with the FDL passing superficially over the FHL) has at least the potential to serve as one source of communication in diabetic foot infections from the medial plantar compartment and FHL to the central and lateral compartments via the FDL and to the rearfoot via the QP.
APA, Harvard, Vancouver, ISO, and other styles
3

Hildreth, Cara M., James R. Padley, Paul M. Pilowsky, and Ann K. Goodchild. "Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 1 (January 2008): H474—H480. http://dx.doi.org/10.1152/ajpheart.01009.2007.

Full text
Abstract:
Serotonin (5-HT) is crucial to normal reflex vagal modulation of heart rate (HR). Reduced baroreflex sensitivity [spontaneous baroreflex sensitivity (sBRS)] and HR variability (HRV) reflect impaired neural, particularly vagal, control of HR and are independently associated with depression. In conscious, telemetered Flinders-Sensitive Line (FSL) rats, a well-validated animal model of depression, we tested the hypothesis that cardiovascular regulatory abnormalities are present and associated with deficient serotonergic control of reflex cardiovagal function. In FSL rats and control Flinders-Resistant (FRL) and Sprague-Dawley (SD) rat strains, diurnal measurements of HR, arterial pressure (AP), activity, sBRS, and HRV were made. All strains had normal and similar diurnal variations in HR, AP, and activity. In FRL rats, HR was elevated, contributing to the reduced HRV and sBRS in this strain. In FSL rats, sBRS and high-frequency power HRV were reduced during the night, indicating reduced reflex cardiovagal activity. The ratio of low- to high-frequency bands of HRV was increased in FSL rats, suggesting a relative predominance of cardiac sympathetic and/or reflex activity compared with FRL and SD rats. These data show that conscious FSL rats have cardiovascular regulatory abnormalities similar to depressed humans. Acute changes in HR, AP, temperature, and sBRS in response to 8-hydroxy-2-(di- n-propylamino)tetralin, a 5-HT1A, 5-HT1B, and 5-HT7 receptor agonist, were also determined. In FSL rats, despite inducing an exaggerated hypothermic effect, 8-hydroxy-2-(di- n-propylamino)tetralin did not decrease HR and AP or improve sBRS, suggesting impaired serotonergic neural control of cardiovagal activity. These data suggest that impaired serotonergic control of cardiac reflex function could be one mechanism linking reduced sBRS to increased cardiac risk in depression.
APA, Harvard, Vancouver, ISO, and other styles
4

Goss, David A., Adam Halverson, Terrence M. Philbin, and Patrick E. Bull. "Minimally Invasive Retrograde Method of Harvesting the Flexor Hallucis Longus Tendon: A Cadaveric Study." Foot & Ankle International 40, no. 10 (July 1, 2019): 1214–18. http://dx.doi.org/10.1177/1071100719858074.

Full text
Abstract:
Background: Use of the flexor hallucis longus (FHL) tendon is well described for several tendon augmentation procedures. Harvesting the FHL through an open medial approach is commonly done, but is associated with anatomic risks. Recently, several authors have described a minimally invasive (MI) technique to harvest the FHL tendon utilizing a hamstring tendon stripper commonly used in ACL reconstruction. The purpose of this study was to evaluate the safety and effectiveness of harvesting the FHL tendon using this novel minimally invasive retrograde approach. Methods: The FHL tendon was harvested through a transverse plantar incision over the interphalangeal joint of the great toe in 10 fresh-frozen cadaver lower extremities. A lateral-based incision for peroneal tendon repair was made and the FHL was retrieved. Tendon length, complications, and interconnections between the FHL and flexor digitorum longus (FDL) were recorded and classified. The specimens were then dissected by a single surgeon in a standardized fashion, and damage to any surrounding structures was recorded. Results: The average length of the FHL tendon from the distal stump to the first intertendinous connection was 13.3 cm (range 8.8-16 cm, SD 2.3 cm). Eight cadavers demonstrated Plaass type 1 interconnections whereas 2 demonstrated type 3. There was no injury to the medial and lateral plantar arteries and nerves, plantar plate, or FDL tendons. One FHL tendon was amputated at the level of the sustentaculum during graft harvest. No injury of the medial neurovascular structures occurred with retrieval of the FHL tendon through the lateral incision. Conclusions: We found that care must be taken when approaching the sustentaculum with the tendon harvester in order to avoid amputation of the graft against a hard bony endpoint. Additionally, flexion and extension of the lesser toes could aid in successful tendon harvest when tendon interconnections were encountered. Clinical Relevance: Using this MI technique appears to be a safe and effective way to obtain a long FHL tendon graft for tissue augmentation.
APA, Harvard, Vancouver, ISO, and other styles
5

Strich, David, Gilad Karavani, Shalom Edri, and David Gillis. "TSH enhancement of FT4 to FT3 conversion is age dependent." European Journal of Endocrinology 175, no. 1 (July 2016): 49–54. http://dx.doi.org/10.1530/eje-16-0007.

Full text
Abstract:
ObjectiveWe previously reported increasing free T3 (FT3) to free T4 (FT4) ratios as thyroid-stimulating hormone (TSH) increases within the normal range in children. It is not known if this phenomenon is age-related among humans, as previously reported in rats. This study examines the relationships between TSH and FT3/FT4 ratios in different ages.DesignRetrospective examination of thyroid tests from patients without thyroid disease from community clinics.MethodsFree T3, free T4, and TSH levels from 527 564 sera collected from patients aged 1 year or greater were studied. Exclusion criteria were the following: missing data, TSH greater than 7.5mIU/L, and medications that may interfere with thyroid hormone activity. A total of 27 940 samples remaining after exclusion were stratified by age. Samples with available anthropometric data were additionally stratified for body mass index (BMI). Correlations of TSH to FT4, FT3, and FT3/FT4 ratios by age group were examined.ResultsUp to age 40, for each increasing TSH quartile, FT3 and the FT3/FT4 ratio increased and FT4 decreased significantly (for both FT3, FT4 and FT3/FT4 ratio,P<0.05 for every TSH quartile when compared with the 1st quartile, except FT3 in the 30–40 age group). In older age groups, increasing TSH was not associated with increased FT3/FT4 ratio.ConclusionAs TSH levels increase, FT3/FT4 ratios increase until age 40, but this differential increase does not occur in older age groups. This may reflect a decrease in thyroxine (T4) to triiodothyronine (T3) conversion with age, which may be part of the aging process.
APA, Harvard, Vancouver, ISO, and other styles
6

Yeasmin, Shahanara, AFM Anwar Hossain, Tahmina Yeasmin, Md Ruhul Amin, Qazi Shamima Akhter, Md Abdul Kader, and Mostafa Kamal. "Study of serum FT3, FT4 and TSH in pregnant women." Journal of Dhaka Medical College 23, no. 1 (March 26, 2015): 68–72. http://dx.doi.org/10.3329/jdmc.v23i1.22697.

Full text
Abstract:
Background: Thyroid diseases have a strong predominance in woman of childbearing age. Pregnancy may be associated with thyroid dysfunction. The aim of the present study was to assess the serum FT3, FT4 and TSH levels in pregnant women. Methods: This cross-sectional analytical study was done in the Department of Physiology of Dhaka Medical College, Dhaka, from July 2006 to June 2007. Total 50 apparently healthy women of low socioeconomic class, age ranged from 18-40 years were selected from the Outpatient Department of Urban Primary Health Care Project (UPHCP) at Mirpur, Dhaka. Out of them 30 pregnant women of different trimester were taken as study group (group A) and 20 age matched non pregnant women were taken as control (group B). Serum FT3, FT4 and TSH levels were parameters in both groups. Statistical analysis was done by the SPSS version 12.0. Results: The mean serum FT3 levels were 6.36±1.16 pmol/L and 6.381.36 pmol/L in group A (Study) and group B (control) respectively. The mean serum FT4 levels were 20.25±4.77 pmol/L and 19.39±8.17 pmol/L in group A (Study) and group B (control) respectively. The mean serum TSH levels were 0.96±0.96 mIu/L and 1.27±0.86 mIu/L in group A (Study) and group B (control) respectively. The difference was not significant (p>0.05) between group A and B. Conclusion: From the results obtained in the present study, it may be concluded that there is no change of serum FT3, FT4 and TSH level in pregnancy. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22697 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 68-72
APA, Harvard, Vancouver, ISO, and other styles
7

Yeasmin, Shahanara, AFM Anwar Hossain, Tahmina Yeasmin, and Md Ruhul Amin. "Study of Serum FT3, FT4 and TSH Levels in Pregnant Women." Medicine Today 27, no. 2 (October 22, 2016): 1–4. http://dx.doi.org/10.3329/medtoday.v27i2.30033.

Full text
Abstract:
Thyroid disease have a strong predominance in woman of childbearing age. Pregnancy may be associated with thyroid dysfunction. Our objective was to assess the serum FT3, FT4 and TSH levels in pregnant women. This cross-sectional analytical study was done in the Department of Physiology of Dhaka Medical College from July 2006- June 2007. Total 50 apparently healthy women of low socioeconomic class, age ranged from 18- 40 years were selected from the Outpatient Department of urban primary health care project at Mirpur, Dhaka. Out of them 30 pregnant women of different trimester were taken as study group and 20 age matched non pregnant women were taken as control. Serum FT3, FT4 and TSH levels were parameters in both groups. Statistical analysis was done by the SPSS 12.0 programme. The means ( SD) of serum FT3 levels were 6.36 1.16 p mol/L and 6.38 1.38 p mol/L, FT4 levels were 20.25 4.77 pmol/L and 19.39 8.17 pmol/L and TSH levels were 0.96 0.96 mIu/L and 1.27 0.86 mIu/L in group A (Study) and group B (control) respectively. The difference of means ( SD) of serum FT3 , FT4 and TSH levels were not significant (p>0.05) between group A and B. From the statistical analysis of the results obtained in the present study and their comparison with those of published reports, it may be concluded that there is no change of serum FT3, FT4 and TSH levels in pregnancy.Medicine Today 2015 Vol.27(2): 1-4
APA, Harvard, Vancouver, ISO, and other styles
8

Turner, Stefanie, Carolyn Dress, and Vinod K. Misra. "A 3′-truncating FTL mutation associated with hypoferritinemia without neuroferritinopathy." European Journal of Medical Genetics 64, no. 3 (March 2021): 104159. http://dx.doi.org/10.1016/j.ejmg.2021.104159.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Nahin, Paul J. "Oliver Heaviside: an accidental time traveller." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, no. 2134 (October 29, 2018): 20170448. http://dx.doi.org/10.1098/rsta.2017.0448.

Full text
Abstract:
A little discussed aspect of Heaviside's work in electromagnetics concerned faster-than-light (FTL) charged particles, precursors to the hypothetical tachyon and his discovery that such motion should produce a characteristic radiation signature (now called Cherenkov radiation ). When Heaviside wrote, the time travel implications of FTL were not known (Einstein was still a teenager), and in this paper some speculations are offered on what Heaviside would have thought of FTL time travel, and of the associated (now classic) time travel paradoxes, including the possibility (or not) of sending information into the past. This article is part of the theme issue ‘Celebrating 125 years of Oliver Heaviside's ‘Electromagnetic Theory’’.
APA, Harvard, Vancouver, ISO, and other styles
10

de Ronde, Willem, Yvonne T. van der Schouw, Huibert AP Pols, Louis JG Gooren, Majon Muller, Diederick E. Grobbee, and Frank H. de Jong. "Calculation of Bioavailable and Free Testosterone in Men: A Comparison of 5 Published Algorithms." Clinical Chemistry 52, no. 9 (September 1, 2006): 1777–84. http://dx.doi.org/10.1373/clinchem.2005.063354.

Full text
Abstract:
Abstract Background: Estimation of serum concentrations of free testosterone (FT) and bioavailable testosterone (bioT) by calculation is an inexpensive and uncomplicated method. We compared results obtained with 5 different algorithms. Methods: We used 5 different published algorithms [described by Sodergard et al. (bioTS and FTS), Vermeulen et al. (bioTV and FTV), Emadi-Konjin et al. (bioTE), Morris et al. (bioTM), and Ly et al. (FTL)] to estimate bioT and FT concentrations in samples obtained from 399 independently living men (ages 40–80 years) participating in a cross-sectional, single-center study. Results: Mean bioT was highest for bioTS (10.4 nmol/L) and lowest for bioTE (3.87 nmol/L). Mean FT was highest for FTS (0.41 nmol/L), followed by FTV (0.35 nmol/L), and FTL (0.29 nmol/L). For bioT concentrations, the Pearson correlation coefficient was highest for the association between bioTS and bioTV (r = 0.98) and lowest between bioTM and bioTE (r = 0.66). FTL was significantly associated with both FTS (r = 0.96) and FTV (r = 0.88). The Pearson correlation coefficient for the association between FTL and bioTM almost reached 1.0. Bland-Altman analysis showed large differences between the results of different algorithms. BioTM, bioTE, bioTV, and FTL were all significantly associated with sex hormone binding globulin (SHBG) concentrations. Conclusion: Algorithms to calculate FT and bioT must be revalidated in the local setting, otherwise over- or underestimation of FT and bioT concentrations can occur. Additionally, confounding of the results by SHBG concentrations may be introduced.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "FTL Associates"

1

Smajlovic, Dzenan. "Bestämning av FTO (Fat mass and obesity associated gene) polymorfism." Thesis, University of Kalmar, School of Pure and Applied Natural Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-804.

Full text
Abstract:

Vetenskapen har på senare år försökt fastställa de olika orsaker som leder till fetma. Det är känt att högt energiintag och för lite motion för eller senare hos de flesta individer resulterar i fetma. Det som kan konstateras är att ärftlighet i samspel med miljön vi lever i och påverkas av kan vara den huvudsakliga orsaken till en rad sjukdomar inklusive fetma. På senare år har forskare upptäckt olika gener som på ett eller annan sett är involverade i ämnesomsättningen. En sådan gen är ”fat mass and obesity associated gene”, FTO. Denna gen återfinns på kromosom 16 och har en storlek på 410 kilobaspar. Genen består av nio kodande områden, exoner, och 8 icke kodande områden, introner. Genens funktion är inte fastställd men den tycks både reglera ämnesomsättningen och lipolysen i kroppen. Tidigare studier har konstaterat att en specifik polymorfi i nukleotid rs9939609 medför ökad risk för sjuklig fetma. Uppsättningen som förekommer i nukleotiden uttrycks med A och T. Där dubbel uppsättning av A- allelen klassas som ärftlig risk för fetma. Syftet med detta examensprojekt är att bestämma polymorfi hos FTO genen med hjälp av två olika pyrosekvenserings- baserade metoder. Metod 1 bygger på extraktion av DNA från helblod, sedan amplifiering med PCR och slutligen pyrosekvensering. Metod 2, som jämfördes med metod 1, bygger på PCR direkt på helblod och pyrosekvensering. Blod från 97 friska individer analyserades. Med metod 1 konstaterades förekomst av följande genotyper i provmaterialet, 11 A/A homozygota, det vill säga har riskallelen för fetma i dubbeluppsättning, 50 A/T heterozygota och 36 T/T, vildtyp, som står för minskad ärftlig risk för fetma respektive ingen alls. Med metod 2 som skulle testas, visade sig resultatet överensstämma med metod 1. Med metod 2 erhölls följande resultat 11 A/A, 49 A/T och 34 T/T. Med metod 2 kunde inte 3 prov analyseras. Slutsatsen som kan dras utifrån studien i detta projekt är att metod 2 är likvärdig metod 1 ur analyssynpunkt. Metod 2 är arbetsbesparande tidsmässigt och även billigare då DNA extraktionssteget inte behöver genomföras.

2008:BL10


Science has for a long time looked for an answer for obesity. Obesity is often explained as the problem of the energy we eat and don’t use, but obesity might also have  hereditary causes, where specific genes might play an important role. One of the recent genes found is the fat mass and obesity associated gene, FTO, which is located  on chormosome 16 and has a size of 410 kilobasepairs. The gene is composed of nine exons and eight introns. The function of the gene is not known in detail, but studies has indicated that the gene could play a part in regulating the metabolism and fat cell lipolysis. The purpose with this examination degree project was to compare two methods for analysis of polymorphism in the FTO gene. Method 1 is based on DNA purification from whole blood, amplification with PCR, and finally detection using pyrosequencing. In method 2 PCR is performed on whole blood  directly without prior DNA purification. Pyrosequencing was used with this method also to detect the polymorphism. Earlier studies have shown that theSNP (single nucleotid polymorphism) rs9939609, is associated with increased risk for obesity. Results obtained using method 1 were, 11 individuals had the A/A genotype, 50 was heterozygous (A/T), and 36 the wild type form (T/T), that is not associated with an increased risk for obesity. With method 2, the same result as with method 1 was obtained for the 94 samples of blood analyzed; 11 A/A, 49 A/T and 34 T/T were obtained. Remaining three samples of the 97 analyzed, failed in the pyrosequencing with method 2.

The conclusions  with this degreeprojcet were that method 1 and 2 gave the same results. Method 2 is recommended as it is faster and less expensive, as no prior DNA purification is needed.

APA, Harvard, Vancouver, ISO, and other styles
2

Laber, Samantha. "Deciphering the function of obesity-associated regulatory elements within FTO." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:5608bad0-f089-408b-bf88-792e875f0326.

Full text
Abstract:
Genome-wide association studies have repeatedly shown that the strongest association with obesity arises from variants in the first intron of FTO. The intronic FTO variant rs1421085 is within an adipocyte-specific enhancer and that risk allele carriers have increased IRX3 and IRX5 expression in early adipogenesis (Claussnitzer et al., 2015). Additionally, the same human risk variant was linked to decreased AKTIP, RPGRIP1L and FTO expression in iPSC-derived neurons (Stratigopoulos et al., 2016). These data point towards several likely causal transcripts and tissues at the FTO locus and essentially, several likely mechanisms. Importantly, whether any of the high-risk variants at the FTO locus has any effect on the organismal level has not been addressed so far. The aim of my DPhil project was to use novel gene manipulation strategies in vivo to mechanistically dissect the Fto regulatory circuitry in mouse to pinpoint causal transcripts their effector tissues and to unravel their physiological role in body weight regulation . Using publicly available as well as my own genomic data (ATAC-seq) revealed that the intronic FTO regulatory element in human adipocytes is conserved in mouse pre-adipocytes. Manipulation of the corresponding motif in mouse (by deleting 82 nucleotides at the mouse orthologous region around rs1421085) resulted in depot- and sex-specific alteration of target genes Irx3 and Irx5 in pre-adipocytes. In addition to recapitulating many of the human findings in mouse, my results further unravelled a new level of regulatory complexity at the FTO/Fto locus. When these mutant mice were put on a high fat diet, I found a reduction on overall fat-mass that could be linked to altered mRNA levels of Irx3 and Irx5 in pre-adipocytes. Using a number of genetic techniques, I further showed that Irx3 regulates several processes during adipocyte development, amongst which is modulation of mitochondrial function. In summary, my findings provide new insight into how variants in FTO intron 1 affect adipocyte development and more specifically how IRX3 affects early adipocyte differentiation.
APA, Harvard, Vancouver, ISO, and other styles
3

Cheung, Man Ka. "Investigating the cellular function of the fat mass and obesity associated (FTO) protein." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608074.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Stasiak, Lukasz. "Functional analysis of the fat mass and obesity associated (Fto) gene and protein." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:74abbb87-26f6-423d-b231-2d910f707bcd.

Full text
Abstract:
Genome wide association studies have shown that common variants in the human fat mass and obesity-associated (FTO) gene predispose to obesity and increased fat mass. Mice globally lacking Fto are lean, while mice globally overexpressing Fto have increased body weight due to increased fat mass. FTO protein was shown to localise to the nucleus and demethylate ssDNA and ssRNA. However, the mechanisms by which FTO mediates its effects on body phenotype remain unknown. In this thesis, I found that native FTO can be detected in both the nucleus and the cytoplasm during interphase, and that nuclear FTO was exported through the nuclear membrane during early prophase of the mitotic cell division. I developed co-immunoprecipitation (Co-IP) protocol to pull-down native FTO and identified a large number of new candidate binding partners (CBPs). Computational analysis predicted a role for FTO, and many CBPs, in RNA post-transcriptional modification and processing. I confirmed that the E3 ubiquitin-protein ligase TRIM21 interacts with FTO in multiple mouse tissues and binds FTO through its SPRY domain. Importantly, TRIM21 ubiquitinated FTO which did not lead to its degradation. FTO partially co-localised with TRIM21 and the decapping enzyme DCP2 in mRNA processing bodies (p-bodies). Overexpression of TRIM21 led to the accumulation of FTO outside the nucleus, but was reversed when both proteins were overexpressed. Additionally, I created a muscle specific Fto knock-out mouse model and found that lack of FTO in muscle did not result in the body composition phenotype reported in global Fto knock-out mice. Taken together, FTO can function in both the cytoplasm and the nucleus, where it interacts with TRIM21 which ubiquitinates FTO and potentiates its cytoplasmic localisation. Moreover, function of FTO in muscle does not mediate the obesity phenotype in mice.
APA, Harvard, Vancouver, ISO, and other styles
5

Moens, Thomas Grover. "Molecular mechanisms of pathogenesis in Drosophila models of C9orf72 mutation associated ALS/FTD." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046295/.

Full text
Abstract:
A GGGGCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). Toxicity has been proposed to be due to loss of function of the gene, or by a toxic gain of function, mediated either by the transcription of repetitive sense and antisense RNA molecules, or by translation of RNA into five repetitive dipeptide proteins (DPRs) via repeat associated non-ATG initiated translation. In order to fully assess the role of sense and antisense RNA in vivo, Drosophila models were created where expression of sense or antisense RNA was induced whilst suppressing the formation of DPRs. Despite the formation of cardinal pathological features (RNA binding protein sequestering intranuclear RNA foci) toxicity was not observed in these models suggesting that repeat RNA plays a limited role in disease pathogenesis. When individual DPRs are expressed in Drosophila neurons a strong toxicity is induced by the arginine containing DPRs (poly-GR and poly-PR). To gain insight into the mechanism(s) by which this toxicity occurs, the protein-interactome of these DPRs was investigated in vivo using novel transgenic Drosophila that inducibly express affinity tagged DPR constructs, with identification of interacting proteins using mass spectrometry. In parallel, inclusions of dipeptide proteins were laser-capture microdissected from patient brain tissue and enriched proteins identified by mass spectrometry. The overlap of these datasets suggested that translation may be impaired by the arginine-containing DPRs and methods were adapted to assess the rate of translation in adult Drosophila brains. In parallel, enzymelinked immunosorbent assays (ELISAs) were developed against poly-GR and an abundant non-toxic DPR poly-GP. Measurement of these proteins was performed in various model systems (transfected immortalised cell lines, induced pluripotent stem cell derived neurons, Drosophila models) to confirm the validity of the assays and the potential therapeutic value of interventions.
APA, Harvard, Vancouver, ISO, and other styles
6

ru, neretin@main mccme rssi. "Groups of Vassalomorphisms and Hilbert Spaces Associated with Trees." ESI preprints, 2001. ftp://ftp.esi.ac.at/pub/Preprints/esi1047.ps.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

McMurray, Fiona. "Investigating the role of the fat mass and obesity associated gene (Fto) in obesity." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d7b76f58-6206-47fc-a208-7eeefac7fe27.

Full text
Abstract:
In 2007, a genome wide association study identified a SNP in intron 1 of FTO with increased BMI. Homozygous risk allele carriers are on average three kg heavier than those homozygous for the protective allele. Mouse models have been made, including a conditional knockout, which is lean when globally expressed, as well as a conditional overexpression allele, which has increased body weight when globally expressed. The results from these and other studies suggest that the FTO SNPs lead to weight gain by increasing FTO activity and/or expression. Adult inactivation of Fto using the tamoxifen inducible Cre demonstrated that removal of Fto may be as deleterious as overexpression, with the adult knockout mice having increased fat mass and decreased lean mass. It also supported the role FTO plays in development as adult inactivation of Fto did not increase mortality rates as seen in the global Fto-/- pups. This study also revealed the importance of effective energy expenditure analysis in the mouse. I have confirmed a link between Fto-/- and increased mortality, which may be caused by alterations to developmental processes. Fto-/- reduces cilia formation in MEFs and results in dysregulated cilia formation in specific tissues in Fto-/- embryos. Levels of FTO also appear to affect adipogenic differentiation, which could be due to altered WNT/β-CATENIN signalling. Pharmacological inhibition of FTO was a success in vitro and a compound screen identified FG2216, which could be used in vivo to inhibit FTO. The in vivo effects of FG2216 at 60 mg/kg/2days did not affect body weight or composition in the mouse. My research suggests that there is dysregulation of gut hormones and neuronal signalling pathways in the FTO overexpression mice, which could cause the hyperphagia and increased body weight. These studies add to our current knowledge of FTO function, and suggest a role for FTO in control of body composition, development, and satiety signalling.
APA, Harvard, Vancouver, ISO, and other styles
8

Church, Christopher David. "Mouse models for the functional analysis of the fat mass and obesity associated gene FTO." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534152.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Dietrich, Kerstin. "Molekulare Evolution der metabolisch relevanten Gene MTNR1B (Melatoninrezeptor 1B) und FTO (Fat Mass and Obesity Associated)." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-104580.

Full text
Abstract:
Die hier vorliegende Arbeit zeigt die molekulare Evolution des Melatoninrezeptor 1 B-Gens (MTNR1B) und des Fat Mass and Obesity Associated-Gens (FTO). Für beide Gene wurden in genomweiten Assoziationsstudien (GWAS) Varianten entdeckt, welche zu der Entwicklung einer Adipositas bzw. deren Folgeerkrankungen beitragen können. So wurde für Einzelbasenaustausche (SNPs) im MTNR1B (rs10830963, rs4753426) eine Verschlechterung der Nüchternglukose sowie der Insulinausschüttung gezeigt. Zudem wurde für die Allelfrequenz des rs4753426 C-Allels ein Zusammenhang mit der täglichen Sonnenscheindauer beschrieben. Im FTO wurde eine (tagging) Variante im ersten Intron identifiziert (rs9939609), welche einen erhöhten Körpermasseindex (BMI) zu vermitteln scheint und robust repliziert werden konnte. Zusätzlich konnte in den Sorben, einer in der Lausitz ansässigen Volksgruppe, eine Variante im dritten Intron (rs17818902) beschrieben werden, die ein zusätzliches, stärkeres Assoziationssignal mit einem erhöhten BMI zeigte. Dies führte zu der Fragestellung, ob MTNR1B und FTO einer Konservierung unterlegen sind. Zudem interessierten populationsspezifische Unterschiede, um die Untersuchungen in den Kontext der Hypothese des sparsamen Genotyps stellen zu können. Demnach haben Individuen mit einer genetischen Veranlagung, die ihnen eine effizientere Energiespeicherung ermöglicht, zu Zeiten von Nahrungsmangel einen Fitness-Vorteil gegenüber Nicht-Trägern. Die Konservierung zwischen den Spezies wurde mit Phylogenetic Analysis by Maximum Likelihood (PAML) betrachtet, eine Analyse die auf dem Verhältnis von nichtsynonymen zu synonymen Basenaustauschen innerhalb einer kodierenden Sequenz beruht. Die Selektion innerhalb bzw. zwischen menschlichen Populationen wurde anhand verschiedener populationsgenetischer Variablen näher beleuchtet. Sowohl für MTNR1B als auch für FTO konnte gezeigt werden, dass sie über die betrachteten Spezies im Durchschnitt stark oder sehr stark konserviert sind, was die physiologische Relevanz dieser Gene untermauert. Für MTNR1B zeigte sich zudem, dass es auf dem Ast zum Menschen nicht konserviert, sondern positiv selektioniert ist. Dies kann als Anzeichen für durch die Umwelt bedingte Einflüsse gedeutet werden. Essentielle Residuen des Rezeptors sind jedoch auch hier hochgradig konserviert. Die populationsgenetischen Variablen implizieren bei beiden Genen eine nicht-neutrale Selektion. Während sich beim MTNR1B insbesondere populationsspezifische Unterschiede anhand des Fixierungsindex Fst zeigten, konnten für FTO marginal signifikante Korrelationen zwischen der Konservierung der Haplotypen und der Stärke der Assoziation mit BMI in den Sorben gezeigt werden. Für beide Gene kann die Hypothese des sparsamen Genotyps nicht prinzipiell ausgeschlossen werden, allerdings sind weitere Untersuchungen diesbezüglich von Nöten.
APA, Harvard, Vancouver, ISO, and other styles
10

Killgore, William D. S., Ryan Smith, Elizabeth A. Olson, Mareen Weber, Scott L. Rauch, and Lisa D. Nickerson. "Emotional intelligence is associated with connectivity within and between resting state networks." OXFORD UNIV PRESS, 2017. http://hdl.handle.net/10150/626076.

Full text
Abstract:
Emotional intelligence (EI) is defined as an individual's capacity to accurately perceive, understand, reason about, and regulate emotions, and to apply that information to facilitate thought and achieve goals. Although EI plays an important role in mental health and success in academic, professional and social realms, the neurocircuitry underlying this capacity remains poorly characterized, and no study to date has yet examined the relationship between EI and intrinsic neural network function. Here, in a sample of 54 healthy individuals (28 women, 26 men), we apply independent components analysis (ICA) with dual regression to functional magnetic resonance imaging (fMRI) data acquired while subjects were resting in the scanner to investigate brain circuits (intrinsic resting state networks) whose activity is associated with greater self-reported (i.e. Trait) and objectively measured (i.e. Ability) EI. We show that higher Ability EI, but not Trait EI, is associated with stronger negatively correlated spontaneous fMRI signals between the basal ganglia/limbic network (BGN) and posterior default mode network (DMN), and regions involved in emotional processing and regulation. Importantly, these findings suggest that the functional connectivity within and between intrinsic networks associated with mentation, affective regulation, emotion processing, and reward are strongly related to ability EI.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "FTL Associates"

1

FTL: Todd Dalland, Nicholas Goldsmith : softness, movement and light. Chichester, West Sussex: Academy Editions, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Dumas, Roland. Le fil et la pelote: Mémoires. [France]: Plon, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Dumas, Roland. Le fil et la pelote: Mémoires. [Paris]: Plon, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Doubles-croches: Au fil des jours, au gré des rencontres. Paris: Pommier, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Lawrence, H. Lea. A Hemingway odyssey: Special places in his life. Nashville, Tenn: Cumberland House Pub., 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Kronenburg, Robert H., Todd Dalland, and Nicholas Goldsmith. FTL (Future Tents Limited): Softness Movement and Light (Architectural Monographs No 48). Academy Press, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Graff-Radford, Jonathan, and Keith A. Josephs. Frontotemporal Lobar Degeneration. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0018.

Full text
Abstract:
Frontotemporal dementia (FTD) is an uncommon but important form of degenerative disease characterized by clinical syndromes that result from degeneration of the frontal and temporal lobes. FTD is divided based on clinical presentation into behavioral variant FTD (bvFTD), semantic dementia, and progressive nonfluent/agrammatic aphasia. Several recent studies have advanced our knowledge of the genetics of FTD, with the three most common FTD genes being microtubule-associated protein tau (MAPT) and progranulin (GRN), and a noncoding repeat expansion in C9ORF72. Tau and TDP-43 are the most common pathologies associated with FTD. No pharmacological therapies are currently approved for use in FTD.
APA, Harvard, Vancouver, ISO, and other styles
8

Chung, Dah-Eun Chloe, Jeannette N. Stankowski, and Leonard Petrucelli. Neurobiology of FTD. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0056.

Full text
Abstract:
Frontotemporal dementia (FTD) is the third most common form of dementia, and is one that predominantly affects the frontal and temporal lobes. Pathological heterogeneity of FTD is highlighted in various types of protein inclusions in the brain, which can include tau, TDP-43, or FUS. The discovery of novel genes and mutations associated with FTD, along with the exciting advancement of molecular technologies, led to the development of numerous animal- and human-based model systems. These valuable models allow not only for the investigation of pathogenic mechanisms underlying FTD, but also for their utilization as powerful platforms for the screening of novel therapies.
APA, Harvard, Vancouver, ISO, and other styles
9

Buy America Issues Associated with the State DOT Procurement of Paratransit Vehicles Using FTA Funds. Washington, D.C.: Transportation Research Board, 2007. http://dx.doi.org/10.17226/23167.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Belohlavek, Radim, Joseph W. Dauben, and George J. Klir. Fuzzy Logic and Mathematics. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190200015.001.0001.

Full text
Abstract:
The term “fuzzy logic” (FL) is a generic one, which stands for a broad variety of logical systems. Their common ground is the rejection of the most fundamental principle of classical logic—the principle of bivalence—according to which each declarative sentence has exactly two possible truth values—true and false. Each logical system subsumed under FL allows for additional, intermediary truth values, which are interpreted as degrees of truth. These systems are distinguished from one another by the set of truth degrees employed, its algebraic structure, truth functions chosen for logical connectives, and other properties. The book examines from the historical perspective two areas of research on fuzzy logic known as fuzzy logic in the narrow sense (FLN) and fuzzy logic in the broad sense (FLB), which have distinct research agendas. The agenda of FLN is the development of propositional, predicate, and other fuzzy logic calculi. The agenda of FLB is to emulate commonsense human reasoning in natural language and other unique capabilities of human beings. In addition to FL, the book also examines mathematics based on FL. One chapter in the book is devoted to overviewing successful applications of FL and the associated mathematics in various areas of human affairs. The principal aim of the book is to assess the significance of FL and especially its significance for mathematics. For this purpose, the notions of paradigms and paradigm shifts in science, mathematics, and other areas are introduced and employed as useful metaphors.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "FTL Associates"

1

Shenouda, Marc, Ashley B. Zhang, Anna Weichert, and Janice Robertson. "Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD." In Advances in Neurobiology, 239–63. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89689-2_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Marcocci, Claudio, Alberto Luini, Pilar Santisteban, and Evelyn F. Grollman. "Norepinephrine and TSH Stimulation on Iodide Efflux in FRTL-5 Thyroid Cells Involves Metabolites of Arachidonic Acid and is Associated with the Iodination of Thyroglobulin." In Frontiers in Thyroidology, 397–401. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5260-0_69.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Gustafson, Lars, and Arne Brun. "Frontotemporal dementias." In New Oxford Textbook of Psychiatry, 344–50. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199696758.003.0043.

Full text
Abstract:
Nosological classification of organic dementia is based on current knowledge and theories of aetiology, including genetics, clinical picture, the pathological substrate, and the predominant location of brain damage. This chapter is concerned with dementia syndromes caused by a degenerative disease primarily affecting the frontal and temporal lobes, named frontal-lobe dementia or frontotemporal dementia (FTD). The terminology should be viewed from a historical perspective. The relationship between localized cortical atrophy in dementia and symptoms of aphasia was first reported by Pick in 1892. The pathological account of this lobar degeneration by Alzheimer in 1911 described ‘ballooned’ neurones (Pick cells) and argentophilic globes (Pick bodies), and the clinicopathological entity was named Pick's disease. In the 1980s, attention was drawn to a larger group of frontal-lobe dementias associated with frontotemporal cortical degeneration. The Lund–Manchester consensus of 1994 delineated the prototypical clinical syndrome of FTD with three neuropathological constituents, frontal lobe degeneration of non-Alzheimer type (FLD), (alternatively designated ‘dementia lacking distinctive histology’), Pick's disease, and motor neurone disease (MND) with dementia (FTD-MND). The 1998 consensus on clinical diagnostic criteria for frontotemporal lobar degeneration (FTLD) encompassed two additional dementia syndromes; progressive non-fluent aphasia (PA), and semantic dementia. Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) have also been associated with FTLD. A changing clinical classification is shown in Fig. 4.1.3.1. The addition of important genetic and histochemical characteristics has further added to the complex classification of FTD and FTLD with a risk of developing numerous and partly competing definitions. FTLD may be further subclassified into forms positive or negative for tau and ubiquitin. The ubiquitinated form will be referred to as FTD-U, which is synonymous to FLTD-U.
APA, Harvard, Vancouver, ISO, and other styles
4

Takeda, Akitoshi, and Bruce Miller. "Frontotemporal dementias." In New Oxford Textbook of Psychiatry, edited by John R. Geddes, Nancy C. Andreasen, and Guy M. Goodwin, 405–13. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198713005.003.0041.

Full text
Abstract:
Fronto-temporal dementia (FTD) is a heterogenous clinical syndrome with a progressive decline in behaviour, executive function, and language. Approximately 40% of FTD patients report a family history, and 10–15% of FTD cases show an autosomal dominant pattern of inheritance. FTD often mimics psychiatric disorders because of the prominent behavioural features, and particularly in the early stages, the only manifestation of illness may be purely behavioural. There is significant clinical, pathological, and genetic overlap between FTD and motor neuron disease/amyotrophic lateral sclerosis (FTD-ALS) and two atypical Parkinsonian syndromes—progressive supranuclear palsy (PSP) and cortico-basal degeneration (CBD). FTD is associated with non-Alzheimer’s disease pathology and the molecular aggregation of specific proteins—tau, TAR-DNA binding protein (TDP), and fused in sarcoma (FUS). Advances in clinical, imaging, and molecular characterization have increased the accuracy of FTD diagnosis. At present, appropriate management of FTD symptoms involves a combination of pharmacological therapy with techniques involving behavioural, physical, and environmental manipulation.
APA, Harvard, Vancouver, ISO, and other styles
5

Novak, Peter. "Case 39: Hypothermia in Frontotemporal Dementia." In Autonomic Testing, edited by Peter Novak, 229–32. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190889227.003.0044.

Full text
Abstract:
This case illustrates severe generalized autonomic failure associated with frontotemporal dementia (FTD) and hypothermia. The tilt test provoked severe sustained orthostatic hypotension associated with reduced heart rate response and a decline in cerebral blood flow velocity. Thermoregulation is a vital function of autonomic nervous system.
APA, Harvard, Vancouver, ISO, and other styles
6

Blass, David M. "Frontotemporal Dementia." In Psychiatric Aspects of Neurologic Diseases. Oxford University Press, 2008. http://dx.doi.org/10.1093/oso/9780195309430.003.0017.

Full text
Abstract:
Frontotemporal dementia (FTD) is a family of neurodegenerative diseases and syndromes that most commonly involve the frontal and temporal lobes, producing dramatic alterations of personality, behavior, language, and other cognitive abilities (McKhann et al., 2001). Age of onset tends to be younger than in Alzheimer’s disease (AD), with most patients becoming symptomatic in the sixth decade of life. Although population-based epidemiologic studies of FTD have found a prevalence of approximately 5–10 per 100,000 in patients 50 years of age and older, autopsy-based case series have found that approximately 5% to15% of people with dementia have FTD, a discrepancy suggesting that many cases go undiagnosed during life (Rosso et al., 2003). Recent advances in clinicopathologic correlation have revealed that a number of neurologic conditions previously conceived of as independent disease entities such as progressive supranuclear palsy (PSP), corticobasilar degeneration (CBD), and hippocampal sclerosis dementia are in many cases better classified in the FTD family (McKhann et al., 2001; Blass et al., 2004). Many patients with FTD develop other neurologic syndromes as well, including parkinsonism and amyotrophic lateral sclerosis (ALS). FTD is actually a group of clinical syndromes with overlapping neuropathologies. The clinical expression of the disease relates primarily to the anatomic location of disease involvement rather than the neuropathologic subtype; there are many such subtypes. Clinical variants are most distinct early in the disease course, when the degree of anatomic involvement may be limited to discrete regions. As the disease spreads through the brain, many patients have symptoms that become complex and take on char acteristics of other variants. The first clinical FTD variant is one in which behavioral abnormalities and personality changes dominate the clinical presentation. This syndrome is usually associated with disease involvement of the frontal and anterior temporal lobes. In addition, there are two language presentations: primary progressive aphasia and semantic dementia (McKhann et al., 2001). The neurologic syndromes of PSP, CBD, and ALS with dementia are familiar to the neurologist because of their neurologic symptoms; it is noteworthy that patients with any of the previously mentioned syndromes routinely develop the psychiatric symptoms reviewed below.
APA, Harvard, Vancouver, ISO, and other styles
7

"Networking Fundamentals." In Constructing an Ethical Hacking Knowledge Base for Threat Awareness and Prevention, 106–18. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7628-0.ch004.

Full text
Abstract:
This chapter introduces to basics of computer networking and associated widely used essential networking communication protocols. The chapter provides the comparison of OSI and TCP model along with details of internet layer protocols including internet protocol (IP), IP addressing schemes, internet control messaging protocol (ICMP), etc. Next, the chapter discusses transport layer protocols transmission control protocol (TCP) and user datagram protocol (UDP) in detail. Application layer protocols including dynamic host control protocol (DHCP), secure shell (SSH), file transfer protocol (FTP), trivial FTP (TFTP), simple network management protocol (SNMP), hyper text transfer protocol secure (HTTPS), network time protocol (NTP), domain name system (DNS), and simple mail transfer protocol (SMTP) are also explained in this chapter. One just cannot attack a networking protocol without knowing how it works. Having a solid introduction about computer networking and network protocols is fundamental in the ethical hacking world. This chapter quickly revisits all essential concepts related to computer networking.
APA, Harvard, Vancouver, ISO, and other styles
8

Burrell, James R., John R. Hodges, and Olivier Piguet. "Neuropsychological assessment of dementia." In Oxford Textbook of Neuropsychiatry, edited by Niruj Agrawal, Rafey Faruqui, and Mayur Bodani, 115–26. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198757139.003.0011.

Full text
Abstract:
Dementia presents itself in many guises, from its more common forms, such as Alzheimer’s disease (AD), vascular dementia (VaD), and dementia with Lewy bodies (DLB), to the less prevalent such as frontotemporal dementia (FTD). Although clinical diagnostic criteria for dementia, such as the DSM-5, do exist, they can be difficult to implement due to the variability of clinical features at presentation of dementia. This chapter provides an insight into the common neuropsychological profiles associated with the symptoms of various forms of dementia, along with overviews of a number of cognitive assessments, from the Mini-Mental State Examination (MMSE) to the Addenbrooke’s Cognitive Examination-III (ACE-III), along with a description of the way each tests for cognitive deficits.
APA, Harvard, Vancouver, ISO, and other styles
9

Brinton, Daniel A., and Charles P. Wilkinson. "Evaluation and Management." In Retinal Detachment. Oxford University Press, 2009. http://dx.doi.org/10.1093/oso/9780195330823.003.0008.

Full text
Abstract:
Evaluation of a patient for retinal detachment includes a thorough history and a complete ocular exam, including measurement of visual acuity, external examination, ocular motility testing, testing of pupillary reactions, anterior-segment biomicroscopy, tonometry, and binocular indirect ophthalmoscopy with scleral depression. Posterior-segment biomicroscopy, perimetry, and ultrasonography are also sometimes required. Rhegmatogenous retinal detachment is a diagnosis generally made by clinical examination of the retina alone, but a full history, ocular examination, and sometimes selected ancillary tests are also important parts of the evaluation (Figure 4–1). The symptoms of retinal detachment include fl ashes of light, new floaters, visual Field defect, decreased visual acuity, metamorphopsia, and rarely, defective color vision. The perception of light fl ashes, or photopsia, is due to the production of phosphenes by pathophysiologic stimulation of the retina. The retina is activated by light but is also capable of responding to mechanical disturbances. In fact, the most common cause of light fl ashes is posterior vitreous detachment. As the vitreous separates from the retinal surface, the retina is disturbed mechanically, stimulating a sensation of light. This perception is more marked if there are focal vitreoretinal adhesions. Generally, vitreous separation is benign and may almost be regarded as normal in the senescent eye. In approximately 12% of symptomatic posterior vitreous detachments, however, a careful search of the periphery reveals a tear of the retina. If the fl ashes are associated with floaters, it is wise to assume that a retinal tear exists, until proved otherwise. These symptoms demand a prompt and careful examination of the periphery with binocular indirect ophthalmoscopy and scleral indentation. The patient’s localization of the photopsia is of little value in predicting the location of the vitreoretinal pathology. If no breaks are evident in the first examination after symptomatic vitreous detachment, they rarely appear at a later date. If there is no associated hemorrhage or other pathologic condition, the patient needs counseling only. However, if pigment or blood is detected in the vitreous, a follow-up examination is often required. It is prudent to forewarn patients about the symptoms of retinal detachment. Flashes alone or floaters alone are less significant than if they occur together, in which case they are more likely to be associated with a retinal break.
APA, Harvard, Vancouver, ISO, and other styles
10

Becker, Richard C., and Frederick A. Spencer. "Fundamentals and Patient Evaluation." In Fibrinolytic and Antithrombotic Therapy. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195155648.003.0033.

Full text
Abstract:
Thrombophilia is the term used to describe a tendency toward developing thrombosis. This tendency may be inherited, involving polymorphism in gene coding for platelet or clotting factor proteins, or acquired due to alterations in the constituents of blood and/or blood vessels. An inherited thrombophilia is likely if there is a history of repeated episodes of thrombosis or a family history of thromboembolism. One should also consider an inherited thrombophilia when there are no obvious predisposing factors for thrombosis or when clots occur in a patient under the age of 45. Repeated episodes of thromboembolism occurring in patients over the age of 45 raise suspicion for an occult malignancy. A summary of inherited thrombophilias are summarized in Table 24.1. This list continues to grow, as new genetic polymorphisms and combined mutations are being detected. The prevalence of common thrombophilias is shown in Figure 24.1. Factor V Leiden (FVL) mutation and hyperhomocysteinemia are present in nearly 5% of the general population and are often found in patients with venous thrombosis, while deficiencies of antithrombin (AT), protein C, and protein S are relatively uncommon. Elevated levels of factor VIII (FVIII) are uncovered frequently in the general population and in patients with thrombosis. This is not surprising as FVIII is an acute-phase reactant that increases rapidly after surgery or trauma; however, prospective studies have shown that FVIII elevation in some patients cannot be attributed to a stress reaction and probably represents mutations in the genes regulating FVIII synthesis or release (Kyrle et al., 2000). The same may be true for factors IX and XI. The relative risks for thrombosis among patients with inherited thrombophilias have been determined. While AT mutations are the least common, they are associated with a substantial risk of venous thrombosis; similar risk is seen with protein C and S deficiency. In contrast, the lifetime risk of having a thromboembolic event in an individual heterozygous for FVL is comparatively low (Martinelli et al., 1998). Incidence rates markedly increase with age, and are highest among those with AT deficiency, followed by protein C and protein S, and least with FVL.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "FTL Associates"

1

Brčić, Jasna, and Janez Plavec. "NMR study of DNA oligonucleotides containing ALS/FTD associated GGGGCC repeat." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414236.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Marino, E., H. Nguyen, C. Lugni, L. Manuel, and C. Borri. "Irregular Nonlinear Wave Simulation and Associated Loads on Offshore Wind Turbines." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-11047.

Full text
Abstract:
The accuracy of predicted loads on offshore wind turbines depends on the mathematical models employed to describe the combined action of the wind and waves. Using a global simulation framework that employs a domain-decomposition strategy for computational efficiency, this study investigates the effects of nonlinear waves on computed loads on the support structure (monopile) and the rotor-nacelle assembly of a bottom-supported offshore wind turbine. The fully nonlinear (FNL) numerical wave solver is invoked only on sub-domains where nonlinearities are detected; thus, only locally in space and time, a linear solution (and associated Morison hydrodynamics) is replaced by the FNL one. An efficient carefully tuned linear-nonlinear transition scheme makes it possible to run long simulations such that effects from weakly nonlinear up to fully nonlinear events, such as imminent breaking waves, can be accounted for. The unsteady nonlinear free-surface problem governing the propagation of gravity waves is formulated using potential theory and a higher-order boundary element method (HOBEM) is used to discretize Laplace’s equation. The FNL solver is employed and associated hydrodynamic loads are simulated in conjunction with aerodynamic loads on the rotor of a 5-MW wind turbine using the NREL open-source software, FAST. We assess load statistics associated with a single severe sea state. Such load statistics are needed in evaluating relevant load cases specified in offshore wind turbine design guidelines; in this context, the influence of nonlinear wave modeling and its selection over alternative linear or linearized wave modeling is compared. Ultimately, a study such as this one will seek to evaluate long-term loads using the FNL solver in computations directed towards reliability-based design of offshore wind turbines where a range of sea states will need to be evaluated.
APA, Harvard, Vancouver, ISO, and other styles
3

Marino, E., C. Lugni, L. Manuel, H. Nguyen, and C. Borri. "Simulation of Nonlinear Waves on Offshore Wind Turbines and Associated Fatigue Load Assessment." In ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/omae2014-24623.

Full text
Abstract:
By using a global simulation framework that employs a domain-decomposition strategy for computational efficiency, this study investigates the effects of fully nonlinear (FNL) waves on the fatigue loads exerted on the support structure (monopile) of a fixed-bottom offshore wind turbine. A comparison is made with more conventional linear wave hydrodynamics. The FNL numerical wave solver is invoked only on specific sub-domains where nonlinearities are detected; thus, only locally in space and time, a linear wave solution is replaced by the FNL results as input to the Morison equation used for the hydrodynamic loads. The accuracy and efficiency of this strategy allows long timedomain simulations where strongly nonlinear free-surface phenomena, like imminent breaking waves, are accounted for in the prediction of structural loads. The unsteady nonlinear free-surface problem governing the propagation of gravity waves is formulated using potential theory and a higher-order boundary element method (HOBEM) is used to discretize Laplace’s equation. The FNL solver is employed and associated hydrodynamic loads are predicted in conjunction with aerodynamic loads on the rotor of a 5-MW wind turbine using the NREL open-source software, FAST. We assess fatigue loads by means of both time- and frequency-domain methods. This study shows that the use of linear theory-based hydrodynamics can lead to significant underestimation of fatigue loads and damage.
APA, Harvard, Vancouver, ISO, and other styles
4

Manka, P., L. Bechmann, S. Sydor, J. Best, A. Canbay, G. Gerken, WK Syn, and H. Wedemeyer. "Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677173.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Aleksandrowicz, Gadi, Eli Arbel, Roderick Bloem, Timon Ter Braak, Sergei Devadze, Goerschwin Fey, Maksim Jenihhin, et al. "Designing reliable cyber-physical systems overview associated to the special session at FDL'16." In 2016 Forum on Specification and Design Languages (FDL). IEEE, 2016. http://dx.doi.org/10.1109/fdl.2016.7880382.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Thurman, Samuel T., and James R. Fienup. "Signal-to-Noise Ratio Tradeoffs Associated with Coarsely Sampled Fourier Transform Spectroscopy." In Fourier Transform Spectroscopy. Washington, D.C.: OSA, 2007. http://dx.doi.org/10.1364/fts.2007.fwa5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Ronmark, Eva, Hayley R. James, Jillian M. Roper, Mariko Mori, Bo Lundback, and Thomas A. Platts-Mills. "Do IgG And IgG4 Isotype Antibodies To The Cat Allergen Fel D 1 Alter The Risk For Asthma Associated With IgE Antibodies To Fel D 1?" In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2774.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Emily A. Carter, John P. Fulton, and Brian J. Burton. "Site Impacts Associated with Biomass Removals in Lower Alabama." In 2005 Tampa, FL July 17-20, 2005. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2005. http://dx.doi.org/10.13031/2013.20066.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Ciravegna, Gabriele, Francesco Giannini, Marco Gori, Marco Maggini, and Stefano Melacci. "Human-Driven FOL Explanations of Deep Learning." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/309.

Full text
Abstract:
Deep neural networks are usually considered black-boxes due to their complex internal architecture, that cannot straightforwardly provide human-understandable explanations on how they behave. Indeed, Deep Learning is still viewed with skepticism in those real-world domains in which incorrect predictions may produce critical effects. This is one of the reasons why in the last few years Explainable Artificial Intelligence (XAI) techniques have gained a lot of attention in the scientific community. In this paper, we focus on the case of multi-label classification, proposing a neural network that learns the relationships among the predictors associated to each class, yielding First-Order Logic (FOL)-based descriptions. Both the explanation-related network and the classification-related network are jointly learned, thus implicitly introducing a latent dependency between the development of the explanation mechanism and the development of the classifiers. Our model can integrate human-driven preferences that guide the learning-to-explain process, and it is presented in a unified framework. Different typologies of explanations are evaluated in distinct experiments, showing that the proposed approach discovers new knowledge and can improve the classifier performance.
APA, Harvard, Vancouver, ISO, and other styles
10

Arnaout, Karim, Mustapha Khalife, and Amr Hanbali. "Abstract 1885: Malignancies associated with immune thrombocytopenic purpura." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1885.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "FTL Associates"

1

Ruiz, Pablo, Craig Perry, Alejando Garcia, Magali Guichardot, Michael Foguer, Joseph Ingram, Michelle Prats, Carlos Pulido, Robert Shamblin, and Kevin Whelan. The Everglades National Park and Big Cypress National Preserve vegetation mapping project: Interim report—Northwest Coastal Everglades (Region 4), Everglades National Park (revised with costs). National Park Service, November 2020. http://dx.doi.org/10.36967/nrr-2279586.

Full text
Abstract:
The Everglades National Park and Big Cypress National Preserve vegetation mapping project is part of the Comprehensive Everglades Restoration Plan (CERP). It is a cooperative effort between the South Florida Water Management District (SFWMD), the United States Army Corps of Engineers (USACE), and the National Park Service’s (NPS) Vegetation Mapping Inventory Program (VMI). The goal of this project is to produce a spatially and thematically accurate vegetation map of Everglades National Park and Big Cypress National Preserve prior to the completion of restoration efforts associated with CERP. This spatial product will serve as a record of baseline vegetation conditions for the purpose of: (1) documenting changes to the spatial extent, pattern, and proportion of plant communities within these two federally-managed units as they respond to hydrologic modifications resulting from the implementation of the CERP; and (2) providing vegetation and land-cover information to NPS park managers and scientists for use in park management, resource management, research, and monitoring. This mapping project covers an area of approximately 7,400 square kilometers (1.84 million acres [ac]) and consists of seven mapping regions: four regions in Everglades National Park, Regions 1–4, and three in Big Cypress National Preserve, Regions 5–7. The report focuses on the mapping effort associated with the Northwest Coastal Everglades (NWCE), Region 4 , in Everglades National Park. The NWCE encompasses a total area of 1,278 square kilometers (493.7 square miles [sq mi], or 315,955 ac) and is geographically located to the south of Big Cypress National Preserve, west of Shark River Slough (Region 1), and north of the Southwest Coastal Everglades (Region 3). Photo-interpretation was performed by superimposing a 50 × 50-meter (164 × 164-feet [ft] or 0.25 hectare [0.61 ac]) grid cell vector matrix over stereoscopic, 30 centimeters (11.8 inches) spatial resolution, color-infrared aerial imagery on a digital photogrammetric workstation. Photo-interpreters identified the dominant community in each cell by applying majority-rule algorithms, recognizing community-specific spectral signatures, and referencing an extensive ground-truth database. The dominant vegetation community within each grid cell was classified using a hierarchical classification system developed specifically for this project. Additionally, photo-interpreters categorized the absolute cover of cattail (Typha sp.) and any invasive species detected as either: Sparse (10–49%), Dominant (50–89%), or Monotypic (90–100%). A total of 178 thematic classes were used to map the NWCE. The most common vegetation classes are Mixed Mangrove Forest-Mixed and Transitional Bayhead Shrubland. These two communities accounted for about 10%, each, of the mapping area. Other notable classes include Short Sawgrass Marsh-Dense (8.1% of the map area), Mixed Graminoid Freshwater Marsh (4.7% of the map area), and Black Mangrove Forest (4.5% of the map area). The NWCE vegetation map has a thematic class accuracy of 88.4% with a lower 90th Percentile Confidence Interval of 84.5%.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'FTL Associates' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography