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Journal articles on the topic 'FTO rs9939609'

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Published: 11 September 2021
Last updated: 30 July 2025

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1

Wang, Li, QiZhong Yi, Hua Yao, et al. "Correlations between FTO Gene Polymorphisms and TSH Level in Uyghur Chinese Patients with Type 2 Diabetes." BioMed Research International 2021 (June 26, 2021): 1–7. http://dx.doi.org/10.1155/2021/6646750.

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Objective. The aim of this study was to investigate the correlation between polymorphisms in the FTO gene and TSH level in Uyghur patients with type 2 diabetes in the Xinjiang region. Material and Methods. This cohort was made up of 498 Uyghur patients with type 2 diabetes who underwent genotype screening for rs8050136 and rs9939609 using the Sequenom MassARRAY system. The distribution frequencies of the genotypes and alleles at rs8050136 and rs993960 were compared between two patient groups, those with TSH < 2.5 mU/L and those with TSH ≥ 2.5 mU/L group. We further evaluated the relationshi
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Nurmaliana, Tati, and Vector Stephen Dewangga. "Polimorfisme Gen FTO Rs9939609 Terhadap Konsentrasi Trigliserida Pada Subyek Obesitas Sentral." Jurnal Analis Kesehatan 12, no. 2 (2023): 65–70. http://dx.doi.org/10.26630/jak.v12i2.3908.

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Obesitas sentral merupakan keadaan bagian perut bagian tengah terdapat lemak yang berlebih. Penumpukan lemak berlebihan mengakibatkan peningkatan jumlah asam lemak bebas yang dihidrolisis LPL endotel. Free Fatty Acid (FFA) dilepaskan karena adanya penimbunan lemak yang berlebihan juga menghambat lipogenesis sehingga menghambat klirens serum triasilgliserol dan terjadinya hipertrigliseridemia. Gen FTO (fat mass and obesity associated) rs9939609 banyak dikaitkan dengan massa lemak dan obesitas. Tujuan penelitian untuk mengetahui gambaran polimorfisme gen FTO rs9939609 dan faktor risiko polimorfi
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HIZ ÇİÇEKLİYURT, Meliha Merve, Sevilay OĞUZ KILIÇ, and Levent ELMAS. "EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION." Journal of Scientific Perspectives 4, no. 4 (2020): 255–62. http://dx.doi.org/10.26900/jsp.4.022.

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Obesity is a disease that is affected by environmental conditions as well as genetic predisposition. This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity. The relation between the rs9939609 polymorphism and obesity in 80 ower-weight (BMI≥30) and 131 under/normal weight (BMI<30) subjects was examined. The allele and genotype frequencies of each group were determined by the allele counting method. The relationship between single nucleotide exchange and obesity risk was calculated using the odds ratio. Statistical analyzes were
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Yusof, Hartini, Nur Aimi Mohd Rodzi, Nurhanis Syahira Shakir, Azrina Begam Mohd Ali, Zana Jamal Kareem, and Fazleen Haslinda Mohd Hatta. "DEVELOPMENT OF PCR-BASED GENOTYPING METHOD FOR FAT MASS OBESITY-ASSOCIATED (FTO) GENE POLYMORPHISM RS9939609." Journal of Health and Translational Medicine sp2023, no. 1 (2023): 51–54. http://dx.doi.org/10.22452/jummec.sp2023no2.5.

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Malaysia has the highest obesity rate in Southeast Asia and is growing. Environmental and genetic factors influence weight increase and obesity, leading to numerous diseases and mortality. This study aimed to develop a genotyping method to detect FTO gene variant rs9939609, known for its association with body mass index (BMI) and obesity. In-house primers detected rs9939609. Two common primers flanked the variation region, and two more primers identified the wild type and alternative allele. Capillary sequencing verified results. We developed FTO gene variant rs9939609 genotyping. This method
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Abd Ali, A. H., O. V. Bocharova, T. P. Shkurat, M. A. Shkurat, and M. A. Amelina. "Association of Ser447Ter polymorphisms of the LPL gene and rs9939609 of the FTO gene with obesity in children and adolescents in the Rostov-on-Don population." Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, no. 2 (2021): 119–27. http://dx.doi.org/10.17072/1994-9952-2021-2-119-127.

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The aim of this study was to study the correlation between the Ser447ter (C-G) polymorphisms of the LPL gene and rs9939609 of the FTO gene and obesity in children and adolescents of the Rostov region (Russia). A case-control study examined the relationship between the rs9939609 polymorphisms of the FTO gene and Ser447Ter (S447X) of the LPL gene with obesity in 520 children and adolescents of both sexes aged 3 to 18 years: the main group consisted of 370 obese children and adolescents, and the control group - 150 children and adolescents without obesity. Genotyping of polymorphisms T / A rs9939
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6

Priliani, Lidwina, Sukma Oktavianthi, Ria Hasnita, et al. "Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms." PeerJ 8 (January 3, 2020): e8327. http://dx.doi.org/10.7717/peerj.8327.

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Obesity prevalence is increasing worldwide, including in the Bali Province, Indonesia, a popular tourism destination area. The common single nucleotide polymorphisms (SNPs) rs9939609 and rs1421085 of the fat mass and obesity-associated (FTO) gene have been repeatedly reported as one of the important obesity genetic risk factors. We have examined the associations of FTO rs9939609 and rs1421085 SNPs with obesity in the 612 unrelated Balinese subjects living in urban and rural areas. Linear and logistic regression analyses with adjustment for age and gender were employed to investigate the associ
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NING, MEIWEI, AOHONG XU, RONG ZENG, JINRUO XUE, BODA WANG, and XIANG LIU. "The effect of overweight/obesity and FTO gene polymorphism on liver function-related parameters in Chinese adolescents." National Medical Journal of India 37 (February 7, 2025): 248–52. https://doi.org/10.25259/nmji_264_2022.

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Background Overweight/obesity is an important risk factor for liver disease, affecting changes in liver function-related parameters. The fat mass and obesity associated (FTO) gene has been reported to have a link between overweight/obesity and liver fat metabolism. We studied the association of FTO rs9939609 variants with liver function-related parameters and overweight/obesity in Chinese adolescents aged 16 to 26 as freshmen. Methods We examined rs9939609 polymorphisms in 198 control and 173 overweight/obese people, and the genotypes of the samples were analyzed by Sanger sequencing. We inves
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А.А., Яковлева,, Торгунакова, А.В., Соболева, О.А., and Минина, В.И. "FTO (rs9939609), FABP2 (rs1799883), and PPARG (rs1801282) gene polymorphisms and obesity risk in men living in Kuzbass." Nauchno-prakticheskii zhurnal «Medicinskaia genetika, no. 9 (September 30, 2022): 13–16. http://dx.doi.org/10.25557/2073-7998.2022.09.13-16.

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Цель: изучение ассоциаций полиморфизма генов FTO, FABP2, PPARG и ожирения у жителей Кузбасса. Методы. Выборка для исследования составила 395 мужчин, жителей Кузбасса. Средний возраст испытуемых составил 59±7,7 года. Согласно анкетным данным, все обследованные мужчины отнесли себя к русской национальности. Частота ожирения в данной выборке (индекс массы тела>30) составила 46,3%. Генотипирование полиморфных вариантов FTO (rs9939609), FABP2 (rs1799883) и PPARG (rs1801282) проводилось с использованием TaqMan PCR. Далее проводилась проверка ассоциации данных полиморфных вариантов с ожирением в р
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Sun, Yanlei, Jiazhong Sun, Xiang Wang, Wei You, and Mei Yang. "Variants in the fat mass and obesity associated (FTO) gene are associated with obesity and C-reactive protein levels in Chinese Han populations." Clinical & Investigative Medicine 33, no. 6 (2010): 405. http://dx.doi.org/10.25011/cim.v33i6.14592.

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Purpose: Various genetic variants of the fat mass and obesity associated gene (FTO) have been linked to obesity in populations of Europeans. Low-grade inflammation is a key feature of obesity, characterized by elevated plasma levels of C-reactive protein (CRP). In the present study, we have investigated whether the FTO-risk variant is associated with obesity and CRP in the Chinese population. Methods: 1799 individuals aged 50-70 years (896 men and 903 women), including both obese (560 cases) and control individuals, (1200 cases) were recruited. The FTO rs9939609 polymorphism was tested using s
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Tabassum, Sobia, Sadaf Mushtaq, M. Naveed Anwar, et al. "Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population." Pakistan Journal of Medical and Health Sciences 15, no. 11 (2021): 2985–88. http://dx.doi.org/10.53350/pjmhs2115112985.

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Background: Hypertension is a medical condition that often occurs parallel to diabetes and obesity. Previously, the role of fat mass and obesity associated (FTO) gene rs9939609 polymorphism (c.46-23525T>A) with obesity has been reported while prevalence and etiological differences exist among different regions and ethnic groups. Aim: To investigate the association of FTO rs9939609 SNP with hypertension in Pakistani population. Study design: Cross-sectional study. Place and duration of study: Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan from 1st January 2019 to
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11

Berentzen, T., S. I. I. Kring, C. Holst, et al. "Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity." Journal of Clinical Endocrinology & Metabolism 93, no. 7 (2008): 2904–8. http://dx.doi.org/10.1210/jc.2008-0007.

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Abstract Context: A common variant in the first intron of FTO (rs9939609, T/A) is associated with fatness in Caucasians. Objective: FTO may regulate energy homeostasis through the hypothalamus, and we hypothesized that AA-genotypes of rs9939609 FTO have lower energy expenditure and/or a lower level of physical activity. Methods: The study population included all obese young men (body mass index ≥ 31 kg/m2) at the mandatory draft board examinations in the Copenhagen area from 1943 to 1977 and a randomly selected control group from this population. Subgroups of 234 obese and 323 controls were ex
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LEAR, SCOTT A., WEI Q. DENG, GUILLAUME PARÉ, DIAN C. SULISTYONINGRUM, RUTH J. F. LOOS, and ANGELA DEVLIN. "Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort." Genetics Research 93, no. 6 (2011): 419–26. http://dx.doi.org/10.1017/s001667231100036x.

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SummaryThe fat mass and obesity associated (FTO) gene has been implicated with obesity and dietary intake predominantly in European populations. We assessed the association between the FTO rs9939609 variant with body fat distribution and dietary intake in a multi-ethnic population. Aboriginal, Chinese, European and South Asian participants living in Canada (n=706) were assessed for body fat and inner-abdominal fat using imaging techniques, dietary intake and genotyped for the FTO rs9939609 variant. Linear regression was used to study the associations between the minor allele of the variant and
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Ostadsharif, Maryam, Y. Badri Ebrahimi, Farzad R. Khorasgani, and Shahin Eghbalsaied. "Gene Polymorphisms of Human FTO and Obesity in Part of Iranian Population." Recent Advances in Biology and Medicine 5 (2019): 1. http://dx.doi.org/10.18639/rabm.2019.881123.

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As obesity is a multifactorial characteristic, identifying genetic risk factors can help to prevent obesity prevalence. In 2007, FTO (fat mass and obesity associated) gene was identified according to genome-wide association study. Several studies revealed that FTO polymorphisms are responsible for the risk of obesity. The primary objective of our study was assessment of FTO rs9939609 and rs9926289 polymorphisms as risk factors of obesity in part of the Iranian population. In our case–control study, 62 patients with obesity and 75 controls were selected according to their BMI (obese: BMI ≥ 30 k
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Bogdanova, O. G., I. Yu Tarmaeva, E. Yu Sorokina, N. V. Efimova, and I. V. Mylnikova. "Assessment of health risks caused by overweight in children depending on the FTO gene rs9939609 polymorphism." health risk analysis, no. 1 (March 2023): 55–62. http://dx.doi.org/10.21668/health.risk/2023.1.06.eng.

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In this study, we aimed to estimate the association between the rs9939609 FTO (fat mass and obesity associated) polymorphism and a risk of overweight in children living in the Baikal region. We performed a case – control study that included 113 schoolchildren living in industrial centers of the Baikal region (Irkutsk, Angarsk, and Ulan-Ude). Anthropometric parameters were measured and body mass index was calculated with its values being ranked in accordance with the WHO BMI curves depending on a sex and age. Genotyping of the rs9939609 FTO polymorphism was performed by allele-specific amplific
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Bogdanova, O. G., I. Yu Tarmaeva, E. Yu Sorokina, N. V. Efimova, and I. V. Mylnikova. "Assessment of health risks caused by overweight in children depending on the FTO gene rs9939609 polymorphism." Health Risk Analysis, no. 1 (March 2023): 55–62. http://dx.doi.org/10.21668/health.risk/2023.1.06.

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In this study, we aimed to estimate the association between the rs9939609 FTO (fat mass and obesity associated) polymorphism and a risk of overweight in children living in the Baikal region. We performed a case – control study that included 113 schoolchildren living in industrial centers of the Baikal region (Irkutsk, Angarsk, and Ulan-Ude). Anthropometric parameters were measured and body mass index was calculated with its values being ranked in accordance with the WHO BMI curves depending on a sex and age. Genotyping of the rs9939609 FTO polymorphism was performed by allele-specific amplific
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16

Lubis, Siska Mayasari, Miswar Fattah, Harun Alrasyid Damanik, and Jose Rizal Latief Batubara. "Association of Fat Mass and Obesity-associated Gene (FTO) rs9939609 Variant with Early Onset Obesity among Bataknese and Chinese Children in Indonesia: A Case-control Study." Indonesian Biomedical Journal 9, no. 3 (2017): 147. http://dx.doi.org/10.18585/inabj.v9i3.322.

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BACKGROUND: Childhood obesity is associated with the risk of adult obesity and obesity-related chronic disease. The fat mass and obesity-associated gene (FTO) rs9939609 variant are of particular interest because of its association with body mass index (BMI) and obesity-related phenotypes. This study was conducted to investigate the association between FTO gene rs9939609 variant with early onset obesity among Bataknese and Chinese children in Medan, Sumatera Utara, Indonesia.METHODS: The case-control study was carried out at 10 elementary schools in Medan. There were 212 children recruited; 56
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Mangge, Harald, Wilfried Renner, Gunter Almer, Daniel Weghuber, Reinhard Möller, and Renate Horejsi. "Rs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents." Journal of Obesity 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/186368.

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A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adolescents towards degree of obesity, subcutaneous adipose tissue (SAT)-distribution determined by lipometry, early metabolic and preatherosclerotic symptoms. The percentage of AA homozygotes for the rs9939
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Yasri, Sora, and Viroj Wiwanitkit. "Association of FTO rs9939609 with Obesity." Medical Principles and Practice 27, no. 5 (2018): 496. http://dx.doi.org/10.1159/000490495.

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Todendi, Pâmela Ferreira, J. Alfredo Martínez, Cézane P. Reuter, Elisa I. Klinger, Marilu Fiegenbaum, and Andreia Rosane de Moura Valim. "Influence of FTO (Fat mass and obesity) gene and parental obesity on Brazilian children and adolescents adiposity." Journal of Pediatric Endocrinology and Metabolism 33, no. 8 (2020): 975–82. http://dx.doi.org/10.1515/jpem-2019-0594.

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AbstractObjectivesEvaluate the influence of the genetic variant rs9939609 of the FTO gene on anthropometric characteristics and whether parental obesity is related to children and adolescents being overweight.MethodsA total of 2,364 children and adolescents between 6 and 17 years old were genotyped and the lipid profile, plasma glucose level, and anthropometric characteristics were measured to assess adiposity.ResultsThe AA genotype (risk) was associated with higher body mass index (BMI Z-score; p = 0.006), waist circumference (WC; p = 0.001), and triglycerides (p = 0.033). The association of
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Moleres, Adriana, M. Carmen Ochoa, Tara Rendo-Urteaga, et al. "Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case–control study of children." British Journal of Nutrition 107, no. 4 (2011): 533–38. http://dx.doi.org/10.1017/s0007114511003424.

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The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts. This association appears to be dependent on dietary macronutrients. Therefore, the aim of the present study was to evaluate whether dietary fatty acid intake distribution could interact with this FTO genetic variation and obesity in a Spanish case–control study of children and adolescents. A total of 354 Spanish children and adolescents aged 6–18 years (49 % males) were genotyped for the rs9939609 variant of the FTO gene. Anthropometric par
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Bakhashab, Sherin, Najlaa Filimban, Rana M. Altall та ін. "The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study". Genes 11, № 1 (2020): 98. http://dx.doi.org/10.3390/genes11010098.

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Type 2 diabetes mellitus (T2DM) is a common polygenic disease with associated comorbidities. Obesity is a major risk factor for the development of T2DM. The aim of this study is to determine the allele and genotype frequency of peroxisome proliferator-activated receptor-γ (PPARγ) rs1801282, fat mass and obesity-associated protein (FTO) rs9939609, and melanocortin 4 receptor (MC4R) rs2229616 polymorphisms and their association with risk of T2DM in the western Saudi population as mediators of adiposity phenotypes. In a cross-sectional prospective study, genomic DNA from control and T2DM patients
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Ponce-Gonzalez, Jesús G., Ángel Martínez-Ávila, Daniel Velázquez-Díaz, et al. "Impact of the FTO Gene Variation on Appetite and Fat Oxidation in Young Adults." Nutrients 15, no. 9 (2023): 2037. http://dx.doi.org/10.3390/nu15092037.

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The FTO rs9939609 gene, which presents three polymorphisms (AA, AT, and TT), has been associated with the development of obesity through an increased fat accumulation; however, the associations of the gene with other physiological mechanisms, such as appetite or fat oxidation, are still unclear. Therefore, this study aims to evaluate the influence of the FTO rs9939609 gene on different obesity-related factors in young adults. The FTO rs9939609 polymorphism was genotyped in 73 participants (28 women, 22.27 ± 3.70 years). Obesity-related factors included dietary assessment, physical activity exp
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Moraes, Greice Graziela, Cézane Priscila Reuter, Elisa Inês Klinger, Daniel Prá, Andréia Rosane de Moura Valim, and Miria Suzana Burgos. "FTO POLYMORPHISM AND PHYSICAL FITNESS IN OBESE SCHOOLCHILDREN AFTER AN INTERVENTION PROGRAM." Revista Brasileira de Medicina do Esporte 24, no. 1 (2018): 13–16. http://dx.doi.org/10.1590/1517-869220182401160996.

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ABSTRACT Introduction: Recent studies have shown that the association of FTO rs9939609 gene polymorphism with obesity depends on the level of the individual’s physical activity. However, there are some studies that evaluated physical fitness, health, and motor performance in relation to the rs9939609 FTO gene polymorphism. Objective: To evaluate how the rs9939609 FTO gene polymorphism affects the results of physical fitness tests related to health and athletic performance in schoolchildren after 4 months of intervention of physical exercise. Method: The rs9939609 FTO gene polymorphism was geno
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Gomaa, Azza A., Said S. Khamis, Amany M. Zeid, and Mohamed R. Mazen. "The role of genetic polymorphism of fat mass and obesity-associated in lupus nephritis among patients with systemic lupus erythematosus." Journal of The Egyptian Society of Nephrology and Transplantation 25, no. 2 (2025): 82–92. https://doi.org/10.4103/jesnt.jesnt_34_24.

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Background Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by diverse clinical manifestations, with lupus nephritis (LN) representing a severe form of renal involvement. The fat mass and obesity-associated (FTO) gene has been implicated in various autoimmune diseases, but its role in SLE and LN remains understudied. This study aimed to explore the association of FTO gene polymorphisms with LN in Egyptian patients with SLE. Patients and methods In this case-control study, a cohort of 240 Egyptian SLE patients (120 with LN and 120 without LN) was enrolled. PCR of two t
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Айдарбекова, Д. Н., Г. О. Нускабаева, К. Ж. Садыкова та ін. "МЕТАБОЛИЗМДІК СИНДРОМЫ БАР АДАМДАРДА NPY ЖӘНЕ FTO ГЕНДЕР ПОЛИМОРФИЗМДЕРІН ЗЕРТТЕУ: ӘДЕБИ ШОЛУ". Наука и здравоохранение, № 6(26) (30 грудня 2024): 184–95. https://doi.org/10.34689/sh.2024.26.6.021.

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Кіріспе. Кешенді генетикалық зерттеу жүргізу метаболизмдік синдромның генетикалық предикторларының тұтас бейнесін қалыптастыруға мүмкіндік береді, бұл қазіргі заманғы денсаулық сақтаудың басым бағыты - адам ағзасының адекватты генетикалық маркерлерін анықтауға негізделген дербестендірілген медицина болғандықтан маңызды болып саналады, бұл өз кезегінде аталған зерттеудің өзектілігін анықтайды. Зерттеу мақсаты: Метаболизмдік синдромы бар пациенттерде Нейропептид Y және FTO (fat mass and obesity associated) гендерінің полиморфизмі мәселесі бойынша әдебиеттерге шолу жасау. Іздеу стратегиясы: Әдеби
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Sitek, Aneta, Iwona Rosset, Dominik Strapagiel, Małgorzata Majewska, Lidia Ostrowska-Nawarycz, and Elżbieta Żądzińska. "Association of FTO gene with obesity in Polish schoolchildren." Anthropological Review 77, no. 1 (2014): 33–44. http://dx.doi.org/10.2478/anre-2014-0003.

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Abstract The goal of the study was verification of fat mass and obesity-associated (FTO) gene polymorphisms as significant risk factors of obesity in the population of Polish children. Body mass index (BMI) and DNA were evaluated, where DNA was extracted from saliva, collected from 213 children at the age of 6-13 years. DNA was genotyped by PCR (polymerase chain reaction) and HRM (high resolution melting) techniques, as well as by direct sequencing. Three (3) FTO polymorphisms were identified: rs9939609, rs9926289 and rs76804286, the last polymorphism located between the first two. For the fir
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Bochurov, A. A., N. I. Pavlova, A. V. Krylov, and S. K. Kononova. "Association of the FTO gene polymorphism (rs9939609) with body mass index in Yakut population." YAKUT MEDICAL JOURNAL 86, no. 1 (2024): 35–38. https://doi.org/10.25789/ymj.2024.86.08.

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The study is devoted to studying the relationship between the rs9939609 polymorphism of the FTO gene and body mass index (BMI) in the Yakut population. The sample consisted of 521 participants of Yakut nationality without diabetes mellitus and not registered with a dispensary, aged from 18 to 75 years, 222 women and 299 men. An analysis of the distribution of frequencies of occurrence of alleles and genotypes was carried out, as well as an analysis of BMI indicators in groups with different genotypes of the rs9939609 polymorphism of the FTO gene, during which similarities were found in the rat
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West, Nathan R., James Dorling, Alice E. Thackray, et al. "Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women." Journal of Obesity 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/7560707.

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Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean (SD): 34.9 (9.5) years, 26.6 (4.3) kg·m−2) carrying different risk variants of FTO SNP rs9939609. Sex, age, and anthropometric measurements (stature, body mass, and waist circumference) were self-reported using an online questionnaire, and body mass index and waist-to-height ratio were calculated.
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Al-Serri, Ahmad, Suzanne A. Al-Bustan, Maisa Kamkar, et al. "Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?" Medical Principles and Practice 27, no. 2 (2018): 145–51. http://dx.doi.org/10.1159/000486767.

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Objective: To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide. Subjects and Methods: Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait’s Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the
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В.В., Зорина,, Мельникова, Е.С., Иванова, А.А., Гуражева, А.А., and Максимов, В.Н. "Association of FTO rs9939609, TCF7L2 rs7903146, FABP2 rs1799883 polymorphisms with morbid obesity in women." Nauchno-prakticheskii zhurnal «Medicinskaia genetika, no. 7 (July 29, 2022): 52–55. http://dx.doi.org/10.25557/2073-7998.2022.07.52-55.

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Цель. Изучение ассоциации полиморфизмов rs9939609 гена FTO, rs7903146 гена TCF7L2, rs1799883 гена FABP2 с морбидным ожирением у женщин. Материалы и методы. Группа морбидного ожирения (n=192, средний возраст 57,02 ± 7,16 лет, ИМТ> 40 кг/м2) и контрольная группа (n=450, средний возраст 55,44 ± 7,41 лет, ИМТ 20 - 25 кг/м2) сформированы из банка ДНК международного исследования HAPIEE. Генотипирование выполнено методами ПЦР-ПДРФ и ПЦР в режиме реального времени с использованием TaqMan зондов (Applied Biosystems, США). Статистическая обработка полученных результатов осуществлена в программном обе
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Tan, Ava Grace, Annette Kifley, Victoria M. Flood, et al. "Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study." American Journal of Clinical Nutrition 110, no. 4 (2019): 969–76. http://dx.doi.org/10.1093/ajcn/nqz167.

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ABSTRACT Background The obesity–cataract association has been inconsistently reported. The fat mass and obesity–related (FTO) single-nucleotide polymorphism (SNP) rs9939609 is a major SNP associated with obesity and has been used as an instrumental variable for obesity in a Mendelian randomization (MR) approach. An interaction between the FTO SNP and macronutrient intake for obesity was suggested previously. Objective The aim of this study was to assess the associations between obesity and cataract, using FTO SNP rs9939609 as an instrumental variable in an MR approach, and explore interactions
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Labayen, Idoia, Jonatan R. Ruiz, Francisco B. Ortega, et al. "Body size at birth modifies the effect of fat mass and obesity associated (FTO) rs9939609 polymorphism on adiposity in adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study." British Journal of Nutrition 107, no. 10 (2011): 1498–504. http://dx.doi.org/10.1017/s0007114511004600.

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The present study was intended to examine whether ponderal index (PI) at birth modifies the effect of the fat mass and obesity associated (FTO) rs9939609 polymorphism on adiposity in European adolescents. A total of 628 adolescents aged 14·4 (se 1·3) years (56·8 % female) were recruited. PI was calculated from parental reports of birth weight and length (kg/m3), and the BMI (kg/m2), body fat percentage and fat mass index (FMI, kg/m2) were calculated. The rs9939609 polymorphism was genotyped and physical activity assessed by accelerometry. Sex, duration of pregnancy, pubertal status, centre and
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Ramzy, Tarek, Susan El Zayat, Marwa Sheta, Mohamed D. Sarhan, Tamer Elgaabary, and Reham Zeyada. "ESR1 and FTO genetic variants: impact on body weight reduction following bariatric surgery." Egyptian Journal of Surgery 42, no. 3 (2023): 676–84. http://dx.doi.org/10.4103/ejs.ejs_134_23.

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Background Variation in reduction of body weight after bariatric surgery has been observed. Genetics may have a role in the varying outcomes among obese patients. Aim of this research work was to examine the effect of genetic variants within the Fat Mass and Obesity-Related gene (FTO) (rs9939609) and Estrogen Receptor Alpha gene (ESR1) (rs712221) on body weight reduction and blood glucose control in obese individuals, six months following laparoscopic sleeve gastrectomy (LSG). Patients and methods Ninety obese individuals with BMI ≥35 kg/m2 undergoing LSG were recruited and followed up after 6
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Danaher, Jessica, Christos G. Stathis, and Matthew B. Cooke. "Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge." Nutrients 11, no. 10 (2019): 2518. http://dx.doi.org/10.3390/nu11102518.

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The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been associated with obesity, and studies have also shown that environmental/lifestyle interaction such as dietary intake might mediate this effect. The current study investigates the postprandial hormonal regulators of hunger and indirect markers of substrate utilisation and metabolic flexibility following a dietary challenge to determine if suppression of circulating ghrelin levels and/or reduced metabolic flexibility exist between FTO genotypes. One hundred and forty seven healthy, sedentary males and females (
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Diakonova, Aleksandra, Khariton Kurtanov, Nadezhda Pavlova, and Tuyara Aleksandrova. "The FTO, PNPLA3 and TM6SF2 Gene Polymorphisms and Genetic Predisposition to NAFLD in Yakut Population." International Journal of Biomedicine 11, no. 1 (2021): 92–95. http://dx.doi.org/10.21103/article11(1)_oa16.

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The aim of our research was to study the distribution of alleles and genotypes of the FTO rs9939609 SNP, the PNPLA3 rs738409 SNP, and the TM6SF2 rs58542926 SNP in the Yakut population. Methods and Results: A total of 85 DNA samples from the population were tested. An analysis of the frequency distribution of alleles and genotypes of the FTO rs9939609 SNP in the study group did not reveal significant differences. An analysis of the frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP revealed that in men and women the G allele and the homozygous GG genotype prevailed. The
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Santos, Karina dos, Eliane Lopes Rosado, Ana Carolina Proença da Fonseca, et al. "FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial." Nutrients 14, no. 5 (2022): 1050. http://dx.doi.org/10.3390/nu14051050.

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Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (n = 41) or DASH diet (n = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of
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Ruiz Díaz, María Stephany, Diana Mena-Yi, Doris Gómez- Camargo, and Gustavo José Mora-García. "Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess." Colombia Medica 53, no. 2 (2022): e2044874. http://dx.doi.org/10.25100/cm.v53i2.4874.

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Background:
 Fat Mass and Obesity-related (FTO) has been one of the genes consistently related to common obesity. Single nucleotide polymorphisms (SNPs) in FTO have been linked with the IRX3 gene.
 Aim:
 This study was designed by testing the hypothesis that: i) common SNPs in FTO and IRX3 are associated with obesity and related disorders; ii) there is significant linkage disequilibrium between both genes.
 Methods:
 A cross-sectional study was carried out on the Colombian Caribbean Coast. Anthropometric and biochemical variables were measured, and obesity and metaboli
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Рустамов, Мардонкул, та Лиля Гарифулина. "АССОЦИАЦИИ ПОЛИМОРФИЗМА ГЕНА FTO (RS9939609) И PPARG 2 (RS18012820) У ДЕТЕЙ С АБДОМИНАЛЬНЫМ ОЖИРЕНИЕМ И МЕТАБОЛИЧЕСКИМ СИНДРОМОМ". Международный журнал научной педиатрии 3, № 7 (2024): 662–68. http://dx.doi.org/10.56121/2181-2926-2024-3-7-662-668.

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В оригинальной статье представлены результаты исследования частоты распределения полиморфизма гена FTO (rs9939609) и PPARG 2 (rs18012820) у детей с абдоминальным ожирением и проявлениями метаболического синдрома, а также детей с нормальной массой тела. Результаты исследования рекомендуются для широкого использования в практике семейных врачей, врачей педиатров и детских эндокринологов. Цель исследования: изучить особенности ассоциации полиморфизма гена FTO (rs9939609) и PPARG 2 (RS18012820) у детей с абдоминальным типом ожирения и проявлениями МС Материалы и методы. Обследовано 72 ребенка с аб
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Molina-Luque, Rafael, Natalia Ulloa, Manuel Romero-Saldaña, et al. "Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children." Nutrients 13, no. 6 (2021): 2014. http://dx.doi.org/10.3390/nu13062014.

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Background: The increasing prevalence of obesity in children has raised the incidence of Metabolic Syndrome (MetS) in this age group. Given the short- and long-term health impact of MetS, it is essential to prevent its onset by detecting its main triggers. Besides, genetic factors play an essential role in influencing which individuals within a population are most likely to develop obesity in response to a particular environment. In this regard, a common variation in the FTO gene is reproducibly associated with BMI and obesity from childhood and the genetic load has been linked to several card
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Dorling, James L., Alice E. Thackray, James A. King, et al. "No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males." Nutrients 12, no. 12 (2020): 3857. http://dx.doi.org/10.3390/nu12123857.

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The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is linked to obesity and dyslipidemia, yet the independent influence of this polymorphism on blood lipids remains equivocal. We examined the influence of the FTO rs9939609 polymorphism on fasting and postprandial blood lipids in individuals homozygous for the risk A-allele or T-allele with similar anthropometric and demographic characteristics. 12 AA and 12 TT males consumed a standardized meal after fasting overnight. Blood samples were collected at baseline (−1.5 h), before the meal (0 h), and for five hours postprandially to
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Pogozheva, A. V., E. Yu Sorokina, and A. A. Sokolnikov. "Associations between obesity and vitamin D availability depending on the rs2228570 polymorphism of the VDR gene and rs9939609 polymorphism of the FTO gene in the midland and the Extreme North of Russia." Almanac of Clinical Medicine 47, no. 2 (2019): 112–19. http://dx.doi.org/10.18786/2072-0505-2019-47-015.

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Background: It has been shown that vitamin D availability depends on the body mass index (BMI). Genetic polymorphisms contribute to the development of vitamin D deficiency.Aim: To study the availability of vitamin D in the population of various regions of the Russian Federation, depending on the BMI values and the rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene.Materials and methods: The rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene were identified in 311 subjects (136, from the midland of Russia, and 175 from the Far North). Serum 25-hydroxyvitami
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Barbian, Cláudia Daniela, Cézane Priscila Reuter, Jane Dagmar Pollo Renner, et al. "Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents." Journal of Pediatric Genetics 09, no. 01 (2019): 019–26. http://dx.doi.org/10.1055/s-0039-3399511.

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AbstractFew studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk genotypes for obesity of the FTO rs9939609 gene polymorphism, have different anthropometric and biochemical responses to an interdisciplinary intervention program. The quasi-experimental study involved 34 adolescents aged 10 to 15 years. Schoolchildren with AA/AT genotype decreased glucose, total cholesterol, low-density lipoprotein cholest
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López-Bermejo, Abel, Clive J. Petry, Marta Díaz, et al. "The Association between the FTO Gene and Fat Mass in Humans Develops by the Postnatal Age of Two Weeks." Journal of Clinical Endocrinology & Metabolism 93, no. 4 (2008): 1501–5. http://dx.doi.org/10.1210/jc.2007-2343.

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Abstract Objective: Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates. Design: We conducted a cross-sectional, hospital-based study. Patients: Patients included 234 full-term, healthy newborns [122 girls and 112 boys; gestational age (mean, range), 39.0 (37.0–42.0) wk; birth weight, 3.2 (1.9–4.2) kg]. Methods: Cord-blood insulin, IGF-I, IGF-binding protein-1, adiponectin, and visfatin were measured by specific immunoassays
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Lappalainen, Tiina, Jaana Lindström, Jussi Paananen, et al. "Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study." British Journal of Nutrition 108, no. 10 (2012): 1859–65. http://dx.doi.org/10.1017/s0007114511007410.

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A cluster of variants in the fat mass and obesity-associated (FTO) gene are associated with the common form of obesity. Well-documented dietary data are required for identifying how the genetic risk can be modified by dietary factors. The objective of the present study was to investigate the associations between the FTO risk allele (rs9939609) and dietary intake, and to evaluate how dietary intake affects the association between FTO and BMI in the Finnish Diabetes Prevention Study during a mean follow-up of 3·2 years. A total of 479 (BMI >25 kg/m2) men and women were genotyped for rs9939609
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Rivera, Margarita, Adam E. Locke, Tanguy Corre, et al. "Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals." British Journal of Psychiatry 211, no. 2 (2017): 70–76. http://dx.doi.org/10.1192/bjp.bp.116.183475.

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BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for
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Valeeva, Farida V., Kamilya B. Khasanova, Elizaveta A. Sozinova, et al. "Analysis of the association of FTO, PPARG and PPARGC1A gene polymorphisms with carbohydrate metabolism disorders." Kazan medical journal 103, no. 4 (2022): 592–601. http://dx.doi.org/10.17816/kmj2022-592.

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Background. Conducting molecular and genetic studies to investigate susceptibility to multifactorial and polygenic diseases, such as type 2 diabetes melitus and pre-diabetic conditions, is of great importance for the development of personalized prevention programs and the choice of optimal treatment. Taking into account regional and ethnic features, the study of polymorphic markers of candidate genes for fat and carbohydrate metabolism has a great practical value.
 Aim. To investigate associations of polymorphisms of the FTO rs9939609, PPARG rs180128, PPARGC1A rs8192678 genes with the ris
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García-Pastor, Teresa, Iván Muñoz-Puente, Miriam Pérez-Pelayo, Isabel Púa, Justin D. Roberts, and Juan Del Coso. "Maximal Fat Oxidation During Exercise in Healthy Individuals: Lack of Genetic Association with the FTO rs9939609 Polymorphism." Genes 16, no. 1 (2024): 4. https://doi.org/10.3390/genes16010004.

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Background/Objectives: Previous studies suggest that there is a genetically determined component of fat oxidation at rest and during exercise. To date, the FTO gene has been proposed as a candidate gene to affect fat oxidation during exercise because of the association of the “at-risk” A allele with different obesity-related factors such as increased body fat, higher appetite and elevated insulin and triglyceride levels. The A allele of the FTO gene may also be linked to obesity through a reduced capacity for fat oxidation during exercise, a topic that remains largely underexplored in the curr
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Valeeva, Farida V., Nadezhda I. Pavlova, Alexey A. Bochurov, et al. "Comparative analysis of the association of polymorphism rs9939609 of the <i>FTO</i> gene in patients with type 2 diabetes mellitus in the Tatar and Yakut populations." Consilium Medicum 26, no. 4 (2024): 232–37. http://dx.doi.org/10.26442/20751753.2024.4.202662.

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Background. One of the most important gene polymorphisms that may be responsible for the development of insulin resistance is the rs9939609 of the FTO gene. Aim. To investigate the association of the rs9939609 polymorphism of the FTO gene in patients with type 2 diabetes (T2D) in the Yakut and Tatar populations. Materials and methods. The study involved patients with T2D from the population of the Yakut nationality of the Republic of Sakha (Yakutia), Yakutsk (n=132) and the Tatar population – residents of the Republic of Tatarstan (n=134). Molecular genetic analysis was carried out on in the c
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Yusuf, Noaman, Waleed Iqbal, Afsheen Bashir, et al. "Association of Fat, Mass and Obesity (FTO) Gene Polymorphism with Diabetes and Prediabetes in Pakistani Population." Molecular Medicine Communications 3, no. 01 (2023): 11–20. http://dx.doi.org/10.55627/mmc.003.01.0307.

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Obesity and Type 2 Diabetes Mellitus (T2DM) have become the most prevalent public health issue around the world. The etiology of obesity and T2DM is multifactorial; with genes like Fat, Mass and Obesity-associated or FTO gene add to the complexity of the disease and diagnosis. Pakistan has recently been reported the highest prevalence of T2DM in the world. Since Pakistanis have a unique genetic disposition to T2DM due to the influence of genetic variations like rs9939609 in the FTO gene, as it is likely to be quantifiably different against the global genetic backdrop. A total of 300 participan
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Tesi Maratni, Ni Putu, Desak Made Wihandani, and Gde Ngurah Indraguna Pinatih. "The Association of Fat Mass and Obesity-Associated (FTO) rs9939609 Gene Polymorphisms with Leptin Levels in Obese Subjects." International Journal of Health Sciences and Research 15, no. 6 (2025): 241–50. https://doi.org/10.52403/ijhsr.20250631.

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Background: Obesity is a multifactorial disorder that involves intricate interactions between environmental and hereditary factors. Single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated (FTO) gene has been linked to an increased risk of obesity. The hormone leptin, an essential component of energy balance regulation, is highly expressed in obese people, which is indicative of increased fat mass; nevertheless, the physiological effects of leptin are frequently hindered by paradoxical leptin resistance. The purpose of this study is to investigate the relationship
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