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Journal articles on the topic 'Fucose'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 May 2024

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1

Becerra, Jimmy E., María J. Yebra, and Vicente Monedero. "An l-Fucose Operon in the Probiotic Lactobacillus rhamnosus GG Is Involved in Adaptation to Gastrointestinal Conditions." Applied and Environmental Microbiology 81, no. 11 (March 27, 2015): 3880–88. http://dx.doi.org/10.1128/aem.00260-15.

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ABSTRACTl-Fucose is a sugar present in human secretions as part of human milk oligosaccharides, mucins, and other glycoconjugates in the intestinal epithelium. The genome of the probioticLactobacillus rhamnosusGG (LGG) carries a gene cluster encoding a putativel-fucose permease (fucP),l-fucose catabolic pathway (fucI,fucK,fucU, andfucA), and a transcriptional regulator (fucR). The metabolism ofl-fucose in LGG results in 1,2-propanediol production, and theirfucIandfucPmutants displayed a severe and mild growth defect onl-fucose, respectively. Transcriptional analysis revealed that thefucgenes a

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Liu, Xixi, Zhexian Zhang, Hui Mao, Pin Wang, Zhichuang Zuo, Li Gao, Xiang Shi, Ronghua Yin, Na Gao, and Jinhua Zhao. "Characterization of the Hydrolysis Kinetics of Fucosylated Glycosaminoglycan in Mild Acid and Structures of the Resulting Oligosaccharides." Marine Drugs 18, no. 6 (May 29, 2020): 286. http://dx.doi.org/10.3390/md18060286.

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Mild acid hydrolysis is a common method for the structure analysis of fucosylated glycosaminoglycan (FG). In this work, the effects of acid hydrolysis on the structure of FG from S. variegatus (SvFG) and the reaction characteristic were systemically studied. The degree of defucosylation (DF) and molecular weights (Mw) of partial fucosylated glycosaminoglycans (pFs) were monitored by 1H NMR and size-exclusion chromatography, respectively. The kinetic plots of DF, degree of desulfation (DS) from fucose branches, and degree of hydrolysis (DH) of the backbone are exponentially increased with time,

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Pérez-Escalante, Emmanuel, Luis Guillermo González-Olivares, Araceli Castañeda-Ovando, Alma Elizabeth Cruz-Guerrero, John F. Trant, Wendolyne López-Orozco, Luis Humberto Mendoza-Huizar та Sergio Alatorre-Santamaría. "An In Silico Approach to Enzymatic Synthesis of Fucooligosaccharides Using α-l-Fucosidase from Thermotoga maritima". Chemistry Proceedings 3, № 1 (14 листопада 2020): 10. http://dx.doi.org/10.3390/ecsoc-24-08303.

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Fucooligosaccharides comprise the primary group of human milk oligosaccharides. Due to their beneficial properties, a series of synthetic methods have been proposed to obtain them. Enzymatic methods show great promise, and α-l-fucosidase from Thermotoga maritima has emerged as a powerful catalyst for their production. Nonetheless, the enzyme’s limited substrate scope has delayed its wider application. The present work aims to compare the relative reactivity of fucose, pNP-fucose, and ethyl-fucose, while also exploring the molecular interactions of these fucosyl-donors with the enzyme through a

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Ojeda, Kristylea J., Jodie M. Box, and K. Dale Noel. "Genetic Basis for Rhizobium etli CE3 O-Antigen O-Methylated Residues That Vary According to Growth Conditions." Journal of Bacteriology 192, no. 3 (November 30, 2009): 679–90. http://dx.doi.org/10.1128/jb.01154-09.

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ABSTRACT The Rhizobium etli CE3 O antigen is a fixed-length heteropolymer with O methylation being the predominant type of sugar modification. There are two O-methylated residues that occur, on average, once per complete O antigen: a multiply O-methylated terminal fucose and 2-O methylation of a fucose residue within a repeating unit. The amount of the methylated terminal fucose decreases and the amount of 2-O-methylfucose increases when bacteria are grown in the presence of the host plant, Phaseolus vulgaris, or its seed exudates. Insertion mutagenesis was used to identify open reading frames

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5

Nuñez, Samantha, Maria Barra, and Daniel Garrido. "Developing a Fluorescent Inducible System for Free Fucose Quantification in Escherichia coli." Biosensors 13, no. 3 (March 15, 2023): 388. http://dx.doi.org/10.3390/bios13030388.

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L-Fucose is a monosaccharide abundant in mammalian glycoconjugates. In humans, fucose can be found in human milk oligosaccharides (HMOs), mucins, and glycoproteins in the intestinal epithelium. The bacterial consumption of fucose and fucosylated HMOs is critical in the gut microbiome assembly of infants, dominated by Bifidobacterium. Fucose metabolism is important for the production of short-chain fatty acids and is involved in cross-feeding microbial interactions. Methods for assessing fucose concentrations in complex media are lacking. Here we designed and developed a molecular quantificatio

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Chan, Pan F., Karen M. O'Dwyer, Leslie M. Palmer, Jennifer D. Ambrad, Karen A. Ingraham, Chi So, Michael A. Lonetto, et al. "Characterization of a Novel Fucose-Regulated Promoter (PfcsK) Suitable for Gene Essentiality and Antibacterial Mode-of-Action Studies in Streptococcus pneumoniae." Journal of Bacteriology 185, no. 6 (March 15, 2003): 2051–58. http://dx.doi.org/10.1128/jb.185.6.2051-2058.2003.

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ABSTRACT The promoter of the Streptococcus pneumoniae putative fuculose kinase gene (fcsK), the first gene of a novel fucose utilization operon, is induced by fucose and repressed by glucose or sucrose. When the streptococcal polypeptide deformylase (PDF) gene (def1, encoding PDF) was placed under the control of P fcsK , fucose-dependent growth of the S. pneumoniae (P fcsK ::def1) strain was observed, confirming the essential nature of PDF in this organism. The mode of antibacterial action of actinonin, a known PDF inhibitor, was also confirmed with this strain. The endogenous fuculose kinase

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Robles-Gómez, Laura, Paula Sáez-Espinosa, Eliana Marina López-Viloria, Andrea López-Botella, Jon Aizpurua, and María José Gómez-Torres. "Quantification and Topographical Distribution of Terminal and Linked Fucose Residues in Human Spermatozoa by Using Field Emission Scanning Electron Microscopy (FE-SEM)." International Journal of Molecular Sciences 22, no. 21 (November 4, 2021): 11947. http://dx.doi.org/10.3390/ijms222111947.

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The modification of sperm glycocalyx is an essential process during sperm capacitation. The presence and redistribution of terminal and linked fucose have been described during in vitro capacitation in humans. However, the influence of the capacitation time on the quantification and localization of terminal and linked fucose is still unknown. In this study, the quantitative and qualitative changes in fucosyl residues during different in vitro capacitation times (1 and 4 h), are simultaneously characterized by using Aleuria aurantia (AAA) lectin–gold labelling and high-resolution field emission

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8

Tollefsen, S. E., and J. L. Rosenblum. "Role of terminal fucose residues in clearance of human glycosylated alpha-amylase." American Journal of Physiology-Gastrointestinal and Liver Physiology 255, no. 3 (September 1, 1988): G374—G381. http://dx.doi.org/10.1152/ajpgi.1988.255.3.g374.

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Human glycosylated alpha-amylase contains a single biantennary N-linked oligosaccharide that terminates with the structure Fuc alpha 1,3(Gal beta 1,4)GlcNAc. To examine the role of terminal fucose in the clearance of alpha-amylase, we used lectin affinity chromatography to isolate an alpha-amylase fraction that contains two terminal fucoses (one in each branch of the oligosaccharide) and a fraction from which both terminal fucoses have been enzymatically removed. In the rat, the rate of clearance of the radioiodinated fraction with terminal fucoses is rapid (t1/2 = 12 min) and is slowed by man

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Kim, In Jung, and Kyoung Heon Kim. "Thermophilic l-fucose isomerase from Thermanaeromonas toyohensis for l-fucose synthesis from l-fuculose." Process Biochemistry 96 (September 2020): 131–37. http://dx.doi.org/10.1016/j.procbio.2020.05.017.

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Ropartz, David, Lery Marion, Mathieu Fanuel, Jasna Nikolic, Murielle Jam, Robert Larocque, Elizabeth Ficko-Blean, Gurvan Michel, and Helene Rogniaux. "In-depth structural characterization of oligosaccharides released by GH107 endofucanase MfFcnA reveals enzyme subsite specificity and sulfated fucan substructural features." Glycobiology 32, no. 4 (December 4, 2021): 276–88. http://dx.doi.org/10.1093/glycob/cwab125.

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Abstract The extracellular matrix of brown algae represents an abundant source of fucose-containing sulfated polysaccharides (FCSPs). FCSPs include sulfated fucans, essentially composed of fucose, and highly heterogeneous fucoidans, comprising various monosaccharides. Despite a range of potentially valuable biological activities, the structures of FCSPs are only partially characterized and enzymatic tools leading to their deconstruction are rare. Previously, the enzyme MfFcnA was isolated from the marine bacterium Mariniflexile fucanivorans and biochemically characterized as an endo-α-1 → 4-l-

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11

Kato, S., and N. Akamatsu. "Alterations in fucosyl oligosaccharides of glycoproteins during rat liver regeneration." Biochemical Journal 229, no. 2 (July 15, 1985): 521–28. http://dx.doi.org/10.1042/bj2290521.

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[3H]Fucose-labelled glycopeptides in the slices of liver 24h after partial hepatectomy were fractionated on Sephadex G-50. Glycopeptides from regenerating liver contained a higher proportion of lower-Mr components than did controls. Regenerating liver contained a higher proportion of glycopeptides that were bound to concanavalin A-Sepharose and were subsequently eluted with 20mM-methyl alpha-D-glucopyranoside than did controls. Concanavalin A-bound glycopeptides from each source were entirely bound to a lentil lectin-Sepharose column. Both the concanavalin A-bound and -unbound fractions from r

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Kim, Jungyeon, Yu Cheong, Inho Jung, and Kyoung Kim. "Metabolomic and Transcriptomic Analyses of Escherichia coli for Efficient Fermentation of L-Fucose." Marine Drugs 17, no. 2 (January 29, 2019): 82. http://dx.doi.org/10.3390/md17020082.

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L-Fucose, one of the major monomeric sugars in brown algae, possesses high potential for use in the large-scale production of bio-based products. Although fucose catabolic pathways have been enzymatically evaluated, the effects of fucose as a carbon source on intracellular metabolism in industrial microorganisms such as Escherichia coli are still not identified. To elucidate the effects of fucose on cellular metabolism and to find clues for efficient conversion of fucose into bio-based products, comparative metabolomic and transcriptomic analyses were performed on E. coli on L-fucose and on D-

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Autieri, Steven M., Jeremy J. Lins, Mary P. Leatham, David C. Laux, Tyrrell Conway та Paul S. Cohen. "l-Fucose Stimulates Utilization of d-Ribose by Escherichia coli MG1655 ΔfucAO and E. coli Nissle 1917 ΔfucAO Mutants in the Mouse Intestine and in M9 Minimal Medium". Infection and Immunity 75, № 11 (20 серпня 2007): 5465–75. http://dx.doi.org/10.1128/iai.00822-07.

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ABSTRACT Escherichia coli MG1655 uses several sugars for growth in the mouse intestine. To determine the roles of l-fucose and d-ribose, an E. coli MG1655 ΔfucAO mutant and an E. coli MG1655 ΔrbsK mutant were fed separately to mice along with wild-type E. coli MG1655. The E. coli MG1655 ΔfucAO mutant colonized the intestine at a level 2 orders of magnitude lower than that of the wild type, but the E. coli MG1655 ΔrbsK mutant and the wild type colonized at nearly identical levels. Surprisingly, an E. coli MG1655 ΔfucAO ΔrbsK mutant was eliminated from the intestine by either wild-type E. coli M

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Bradley, S. A., C. R. Tinsley, J. A. R. Muiry, and P. J. F. Henderson. "Proton-linked l-fucose transport in Escherichia coli." Biochemical Journal 248, no. 2 (December 1, 1987): 495–500. http://dx.doi.org/10.1042/bj2480495.

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1. Addition of L-fucose to energy-depleted anaerobic suspensions of Escherichia coli elicited an uncoupler-sensitive alkaline pH change diagnostic of L-fucose/H+ symport activity. 2. L-Galactose or D-arabinose were also substrates, but not inducers, for the L-fucose/H+ symporter. 3. L-Fucose transport into subcellular vesicles was dependent upon respiration, displayed a pH optimum of about 5.5, and was inhibited by protonophores and ionophores. 4. These results showed that L-fucose transport into E. coli was energized by the transmembrane electrochemical gradient of protons. 5. Neither steady

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Thai Le, Son, Lenka Malinovska, Michaela Vašková, Erika Mező, Viktor Kelemen, Anikó Borbás, Petr Hodek, Michaela Wimmerová, and Magdolna Csávás. "Investigation of the Binding Affinity of a Broad Array of l-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin." Molecules 24, no. 12 (June 18, 2019): 2262. http://dx.doi.org/10.3390/molecules24122262.

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Series of multivalent α-l-fucoside containing glycoclusters and variously decorated l-fucosides were synthesized to find potential inhibitors of fucose-specific lectins and study the structure-binding affinity relationships. Tri- and tetravalent fucoclusters were built using copper-mediated azide-alkyne click chemistry. Series of fucoside monomers and dimers were synthesized using various methods, namely glycosylation, an azide-alkyne click reaction, photoinduced thiol-en addition, and sulfation. The interactions between compounds with six fucolectins of bacterial or fungal origin were tested

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Ayukawa, Tomonori, Kenjiroo Matsumoto, Hiroyuki O. Ishikawa, Akira Ishio, Tomoko Yamakawa, Naoki Aoyama, Takuya Suzuki, and Kenji Matsuno. "Rescue of Notch signaling in cells incapable of GDP-l-fucose synthesis by gap junction transfer of GDP-l-fucose in Drosophila." Proceedings of the National Academy of Sciences 109, no. 38 (September 4, 2012): 15318–23. http://dx.doi.org/10.1073/pnas.1202369109.

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Notch (N) is a transmembrane receptor that mediates cell–cell interactions to determine many cell-fate decisions. N contains EGF-like repeats, many of which have an O-fucose glycan modification that regulates N-ligand binding. This modification requires GDP-l-fucose as a donor of fucose. The GDP-l-fucose biosynthetic pathways are well understood, including the de novo pathway, which depends on GDP-mannose 4,6 dehydratase (Gmd) and GDP-4-keto-6-deoxy-d-mannose 3,5-epimerase/4-reductase (Gmer). However, the potential for intercellularly supplied GDP-l-fucose and the molecular basis of such trans

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Andrianopoulos, Kanella, Lei Wang, and Peter R. Reeves. "Identification of the Fucose Synthetase Gene in the Colanic Acid Gene Cluster of Escherichia coli K-12." Journal of Bacteriology 180, no. 4 (February 15, 1998): 998–1001. http://dx.doi.org/10.1128/jb.180.4.998-1001.1998.

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ABSTRACT GDP–l-fucose, the substrate for fucosyltransferases for addition of fucose to polysaccharides or glycoproteins in both procaryotes and eucaryotes, is made from GDP–d-mannose.l-Fucose is a component of bacterial surface antigens, including the extracellular polysaccharide colanic acid produced by most Escherichia coli strains. We previously sequenced theE. coli colanic acid gene cluster and identified one of the GDP–l-fucose biosynthetic pathway genes, gmd. We report here the identification of the gene (fcl), located downstream of gmd, encoding the fucose synthetase.

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18

Chow, Wai Ling, and Yuan Kun Lee. "Free fucose is a danger signal to human intestinal epithelial cells." British Journal of Nutrition 99, no. 3 (March 2008): 449–54. http://dx.doi.org/10.1017/s0007114507812062.

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Fucose is present in foods, and it is a major component of human mucin glycoproteins and glycolipids.l-Fucose can also be found at the terminal position of many cell-surface oligosaccharide ligands that mediate cell-recognition and adhesion-signalling pathways. Mucin fucose can be released through the hydrolytic activity of pathogens and indigenous bacteria, leading to the release of free fucose into the intestinal lumen. The immunomodulating effects of free fucose on intestinal epithelial cells (enterocyte-like Caco-2) were investigated. It was found that the presence ofl-fucose up regulated

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Sanz, Sílvia, Giulia Bandini, Diego Ospina, Maria Bernabeu, Karina Mariño, Carmen Fernández-Becerra, and Luis Izquierdo. "Biosynthesis of GDP-fucose and Other Sugar Nucleotides in the Blood Stages of Plasmodium falciparum." Journal of Biological Chemistry 288, no. 23 (April 24, 2013): 16506–17. http://dx.doi.org/10.1074/jbc.m112.439828.

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Carbohydrate structures play important roles in many biological processes, including cell adhesion, cell-cell communication, and host-pathogen interactions. Sugar nucleotides are activated forms of sugars used by the cell as donors for most glycosylation reactions. Using a liquid chromatography-tandem mass spectrometry-based method, we identified and quantified the pools of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, GDP-mannose, and GDP-fucose in Plasmodium falciparum intraerythrocytic life stages. We assembled these data with the in silico functional reconstruction of the parasite m

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Appelmelk, B. J., B. Shiberu, C. Trinks, N. Tapsi, P. Y. Zheng, T. Verboom, J. Maaskant, et al. "Phase Variation in Helicobacter pylori Lipopolysaccharide." Infection and Immunity 66, no. 1 (1998): 70–76. http://dx.doi.org/10.1128/iai.66.1.70-76.1998.

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Helicobacter pylori NCTC 11637 lipopolysaccharide (LPS) expresses the human blood group antigen Lewis x (Lex) in a polymeric form. Lex is β-d-galactose-(1-4)-[α-l-fucose-(1-3)]-β-d-acetylglucosamine. Schematically the LPS structure is (Lex) n -core-lipid A. In this report, we show that Lex expression is not a stable trait but that LPS displays a high frequency (0.2 to 0.5%) of phase variation, resulting in the presence of several LPS variants in one bacterial cell population. One type of phase variation implied the loss of α1,3-linked fucose, resulting in variants that expressed nonsubstituted

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Stanková, J., and M. Rola-Pleszczynski. "Fucose-activated killer (FAK) cells: anomalous killers with augmented cytotoxic activity." Journal of Immunology 135, no. 6 (December 1, 1985): 3719–28. http://dx.doi.org/10.4049/jimmunol.135.6.3719.

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Abstract The effects of monosaccharides on various lymphocyte functions have provided useful probes for the study of cell-cell interactions. In this report, we show that a monosaccharide, alpha-L-fucose, significantly enhances the cytolytic capacity of MLC-induced or preincubated effector cells. The increase in activity was seen against cytotoxic T lymphocyte (CTL) targets (:relevant PHA blasts), natural killer cell (NK) targets (:K562), and natural cytotoxic cell (NC) targets (:MA-160). In addition, traditionally NK-insensitive targets (Raji cells, irrelevant and autologous PHA blasts) were l

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Baysal, Bora, Funda Tüzün, Defne Engür, Seda Özbal, BekirUğur Ergür, Burçin İşcan, Ebru Yücesoy, Nuray Duman, Hasan Özkan, and Abdullah Kumral. "Prophylactic Fucose can Alleviate Lipopolysaccharide-Induced Cholestatic Liver Injury in Neonatal Rats." Journal of Pediatric Infectious Diseases 14, no. 05 (August 13, 2019): 253–59. http://dx.doi.org/10.1055/s-0039-1694710.

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Objectives Cholestasis is a common disease of the liver in premature infants and no specific preventive treatment is currently available. Fucose, one of the monosaccharide building blocks of human milk oligosaccharides, may prevent cholestatic hepatic injury by various mechanisms. The aim of this study was to investigate the protective effect of fucose treatment after endotoxin-induced cholestasis in a rat model. Methods Wistar rat pups were divided into four groups as: group I, control group; group II, fucose-supplemented group; group III, lipopolysaccharide (LPS)-administered group, and grou

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Sakai, T., K. Yamamoto, H. Yokota, K. Hakozaki-Usui, F. Hino, and I. Kato. "Rapid, simple enzymatic assay of free L-fucose in serum and urine, and its use as a marker for cancer, cirrhosis, and gastric ulcers." Clinical Chemistry 36, no. 3 (March 1, 1990): 474–76. http://dx.doi.org/10.1093/clinchem/36.3.474.

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Abstract We devised a kit for use with automated analyzers, for assay of urinary free L-fucose by means of a newly isolated L-fucose dehydrogenase (EC 1.1.1.122), and we measured L-fucose in healthy subjects, cancer patients, and patients with other diseases. It takes 10 min to complete one assay. Absorbance and L-fucose concentration were linearly related up to at least 3.0 mmol/L, analytical recovery was 90-104%, and intra- and interassay coefficients of variation were less than 4.2% and 7.8%, respectively. The concentrations of L-fucose, corrected for creatinine, were significantly higher t

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Anokhina, E. P., M. M. Isuva, S. V. Startseva, E. A. Motina, N. A. Mihailova, and O. S. Korneeva. "INVESTIGATION OF PREBIOTIC, IMMUNOSTIMULATING PROPERTIES OF FUCOSE AND ITS EFFECT ON REPRODUCTIVE FUNCTION." Journal of microbiology epidemiology immunobiology, no. 6 (December 28, 2018): 110–14. http://dx.doi.org/10.36233/0372-9311-2018-6-110-114.

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Aim. Investigation of the effect of fucose in the diet on the gastrointestinal microflora of experimental animals with experimental dysbiosis, the humoral factors of nonspecific immunity, as well as the degree of fucosylation of oocytes and the proportion of oocytes that can be fertilized. Materials and methods. Prebiotic properties of fucose were studied by analyzing the luminal microflora of experimental mice against the background of experimental dysbiosis. Investigation of factors of nonspecific immunity was carried out after immunization of mice according to the level of antibody formatio

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Higgins, Melanie A., and Alisdair B. Boraston. "Structure of the fucose mutarotase fromStreptococcus pneumoniaein complex withL-fucose." Acta Crystallographica Section F Structural Biology and Crystallization Communications 67, no. 12 (November 30, 2011): 1524–30. http://dx.doi.org/10.1107/s1744309111046343.

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Hao, Huilin, Zilei Liu, Peng Wu, and Robert Haltiwanger. "Abstract 1667: Profiling of O-fucose proteome using fucose analog." Journal of Biological Chemistry 299, no. 3 (2023): S392. http://dx.doi.org/10.1016/j.jbc.2023.103744.

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Yuan, Xiao, Tomohiko Nakao, Hina Satone, Kazuyuki Ohara, Yuri Kominami, Miho Ito, Teruki Aizawa, Tomoya Ueno, and Hideki Ushio. "The Effects of Brown Algae-Derived Monosaccharide L-Fucose on Lipid Metabolism in C57BL/6J Obese Mice." Nutrients 12, no. 12 (December 11, 2020): 3798. http://dx.doi.org/10.3390/nu12123798.

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Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic test, mice were fed a high-calorie diet (HCD) containing 0.0001%, 0.001%, 0.01%, and 0.1% L-fucose for one month. The L-fucose supplementation inhibited body weight and visceral fat mass gain in HCD-fed mice. The results of the acute test showed that L-fucose increased the ratio of serum high molecular weight adiponectin and enhanced glucose

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Tomsik, Pavel, Tomas Soukup, Eva Cermakova, Stanislav Micuda, Mohamed Niang, Lenka Sucha, and Martina Rezacova. "L-rhamnose and L-fucose suppress cancer growth in mice." Open Life Sciences 6, no. 1 (February 1, 2011): 1–9. http://dx.doi.org/10.2478/s11535-010-0087-0.

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AbstractIt is documented that deficient fucosylation may play an important role in the pathogenesis of cancer. Since the supplementation of L-fucose could restore fucosylation in both in vitro and in vivo conditions, our intent was to examine the effect of intraperitoneal administration of L-fucose and L-rhamnose (a similar deoxysaccharide) on tumour growth, mitotic activity and metastatic setting of a solid form of Ehrlich carcinoma as well as on the survival rate of tumour bearing mice. Both L-fucose and L-rhamnose exerted a significant suppressive effect on tumour growth (P<0.05). After

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Tomek, Markus B., Bettina Janesch, Matthias L. Braun, Manfred Taschner, Rudolf Figl, Clemens Grünwald-Gruber, Michael J. Coyne, et al. "A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein O-Glycosylation in the Bacteroidetes." Biomolecules 11, no. 12 (November 30, 2021): 1795. http://dx.doi.org/10.3390/biom11121795.

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Diverse members of the Bacteroidetes phylum have general protein O-glycosylation systems that are essential for processes such as host colonization and pathogenesis. Here, we analyzed the function of a putative fucosyltransferase (FucT) family that is widely encoded in Bacteroidetes protein O-glycosylation genetic loci. We studied the FucT orthologs of three Bacteroidetes species—Tannerella forsythia, Bacteroides fragilis, and Pedobacter heparinus. To identify the linkage created by the FucT of B. fragilis, we elucidated the full structure of its nine-sugar O-glycan and found that l-fucose is

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Hidalgo, Andrés, Songhui Ma, Anna J. Peired, Linnea A. Weiss, Charlotte Cunningham-Rundles, and Paul S. Frenette. "Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene." Blood 101, no. 5 (March 1, 2003): 1705–12. http://dx.doi.org/10.1182/blood-2002-09-2840.

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Leukocyte adhesion deficiency type 2 (LADII) is characterized by defective selectin ligand formation, recurrent infection, and mental retardation. This rare syndrome has only been described in 2 kindreds of Middle Eastern descent who have differentially responded to exogenous fucose treatment. The molecular defect was recently ascribed to single and distinct missense mutations in a putative Golgi guanosine diphosphate (GDP)–fucose transporter. Here, we describe a patient of Brazilian origin with features of LADII. Sequencing of the GDP-fucose transporter revealed a novel single nucleotide dele

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Tai, G. H., G. M. Brown, H. G. Morris, T. N. Huckerby, and I. A. Nieduszynski. "Fucose content of keratan sulphates from bovine articular cartilage." Biochemical Journal 273, no. 2 (January 15, 1991): 307–10. http://dx.doi.org/10.1042/bj2730307.

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Alkaline-borohydride-reduced keratan sulphate chains were isolated from bovine articular cartilage (6-8-year-old animals). Nine keratan sulphate fractions of increasing molecular weight were prepared by gel-permeation chromatography on a calibrated column of TSK 30 XL. The samples were analysed for fucose and galactose contents (% by wt. of keratan sulphate) and fucose/galactose ratio. The fucose content increased with molecular size, but the galactose content remained constant. It was concluded that the alpha(1→3)-linked fucose [Thornton, Morris, Cockin, Huckerby, Nieduszynski, Carlstedt, Har

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Stiller, Regine, and Joachim Thiem. "Enzymatic Synthesis of ß-L-Fucose-1-phosphate and GDP-fucose." Liebigs Annalen der Chemie 1992, no. 5 (May 19, 1992): 467–71. http://dx.doi.org/10.1002/jlac.199219920183.

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Minsaas, J. "On two new derivatives of l-fucose: (Second communication on fucose)." Recueil des Travaux Chimiques des Pays-Bas 51, no. 5 (September 3, 2010): 475–82. http://dx.doi.org/10.1002/recl.19320510512.

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34

Lee, Jeong, So Oh, Tony Johnston, Seockmo Ku, and Geun Ji. "Biocatalysis of Fucodian in Undaria pinnatifida Sporophyll Using Bifidobacterium longum RD47 for Production of Prebiotic Fucosylated Oligosaccharide." Marine Drugs 17, no. 2 (February 14, 2019): 117. http://dx.doi.org/10.3390/md17020117.

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Fucosylated oligosaccharide (FO) is known to selectively promote the growth of probiotic bacteria and is currently marketed as a functional health food and prebiotic in infant formula. Despite widespread interest in FO among functional food customers, high production costs due to high raw material costs, especially those related to fucose, are a significant production issue. Therefore, several actions are required before efficient large-scale operations can occur, including (i) identification of inexpensive raw materials from which fucosylated oligosaccharides may be produced and (ii) developm

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35

Saif, Nehal A., Yomna A. Hashem, Heba M. Amin, and Ramy K. Aziz. "In Silico and In Vitro Investigation of the Distribution and Expression of Key Genes in the Fucose Operon of Escherichia coli." Microorganisms 11, no. 5 (May 11, 2023): 1265. http://dx.doi.org/10.3390/microorganisms11051265.

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Many gut bacteria degrade polysaccharides, providing nutritional advantages to their hosts. Fucose, a mucin degradation product, was suggested as a communication molecule between the resident microbiota and external pathogens. However, the precise role and variants of the fucose utilization pathway remain to be elucidated. Here, we computationally and experimentally investigated the fucose utilization operon of E. coli. While the operon is conserved among E. coli genomes, a variant pathway, in which an ABC transporter system replaces the fucose permease gene (fucP), was computationally identif

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Ke, Jun, Ying Li, Chaoqun Han, Ruohang He, Rong Lin, Wei Qian, and Xiaohua Hou. "Fucose Ameliorate Intestinal Inflammation Through Modulating the Crosstalk Between Bile Acids and Gut Microbiota in a Chronic Colitis Murine Model." Inflammatory Bowel Diseases 26, no. 6 (February 3, 2020): 863–73. http://dx.doi.org/10.1093/ibd/izaa007.

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Abstract Background Recurrent intestinal inflammation is frequently associated with aberrant bile acid profiles and microbial community. Fucose exerts a protective effect on commensal bacteria in the case of intestinal pathogen infection. We speculated that fucose might also have certain impact on the microbial ecosystem under the chronic colitis setting. Methods To validate our hypothesis, multi-omics examination was performed in combination with microbiomics and metabonomics in a chronic dextran sulfate sodium (DSS) murine model in the presence or absence of fucose. The 16S RNA sequencing wa

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Marquardt, Thorsten, Kerstin Lühn, Geetha Srikrishna, Hudson H. Freeze, Erik Harms, and Dietmar Vestweber. "Correction of Leukocyte Adhesion Deficiency Type II With Oral Fucose." Blood 94, no. 12 (December 15, 1999): 3976–85. http://dx.doi.org/10.1182/blood.v94.12.3976.

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Abstract We describe a simple, noninvasive, and effective therapy for leukocyte adhesion deficiency type II (LAD II), a rare inherited disorder of fucose metabolism. This disorder leads to an immunodeficiency caused by the absence of carbohydrate-based selectin ligands on the surface of neutrophils as well as to severe psychomotor and mental retardation. The fucosylation defect in LAD II fibroblasts can be corrected by addition of L-fucose to the culture medium. This prompted us to initiate dietary fucose therapy on a patient with LAD II. Oral supplementation of fucose in this patient induced

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Marquardt, Thorsten, Kerstin Lühn, Geetha Srikrishna, Hudson H. Freeze, Erik Harms, and Dietmar Vestweber. "Correction of Leukocyte Adhesion Deficiency Type II With Oral Fucose." Blood 94, no. 12 (December 15, 1999): 3976–85. http://dx.doi.org/10.1182/blood.v94.12.3976.424k06_3976_3985.

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We describe a simple, noninvasive, and effective therapy for leukocyte adhesion deficiency type II (LAD II), a rare inherited disorder of fucose metabolism. This disorder leads to an immunodeficiency caused by the absence of carbohydrate-based selectin ligands on the surface of neutrophils as well as to severe psychomotor and mental retardation. The fucosylation defect in LAD II fibroblasts can be corrected by addition of L-fucose to the culture medium. This prompted us to initiate dietary fucose therapy on a patient with LAD II. Oral supplementation of fucose in this patient induced the expre

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Morton, P. A., and S. M. Steiner. "Extracellular and cellular proteins of rat cells with O-glycosidically linked fucose." Biochemical Journal 225, no. 1 (January 1, 1985): 59–65. http://dx.doi.org/10.1042/bj2250059.

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Fucose-labelled proteins were examined for the release of low-Mr O-linked fucose substituents after mild alkaline-borohydride treatment. A component tentatively identified as glucosylfucitol (DS) and an apparently higher-Mr component (TS), which also contained fucitol, were observed to be released over a broad molecular-size range of proteins. Approx. 90% of the DS-releasing proteins were in the particulate fraction, whereas only approx. 66% of the TS-releasing proteins were in that fraction. In addition to cell-associated proteins, a substantial proportion of DS-containing proteins were shed

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Basak, Prakriti, and Todd L. Lowary. "Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy." Canadian Journal of Chemistry 80, no. 8 (August 1, 2002): 943–48. http://dx.doi.org/10.1139/v02-054.

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The synthesis of three potential boron neutron capture therapy agents (68) is reported. The compounds synthesized are comprised of ortho-carborane covalently attached to L-fucose via C-6. Incorporation of the carborane moiety was achieved either through the reaction of an L-fucose-derived alkyne with decaborane or by the coupling of a 6-amino-L-galactopyranose derivative with carborane carboxylic acid chloride (18).Key words: L-fucose, fucosyltransferase, boron neutron capture therapy, ortho-carborane.

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Ruggiero-Lopez, D., M. C. Biol, P. Louisot, and A. Martin. "Participation of an endogenous inhibitor of fucosyltransferase activities in the developmental regulation of intestinal fucosylation processes." Biochemical Journal 279, no. 3 (November 1, 1991): 801–6. http://dx.doi.org/10.1042/bj2790801.

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During the rat weaning period (about day 19 after birth) the intestinal maturation is accompanied by a drastic increase in the fucose content of mucosal glycoconjugates, concomitant with an increase in fucosyltransferase activities. The regulation of this fucosylation process appears to be a rather complex phenomenon, which involves several systems controlling fucosyltransferase activity or substrate availability. An endogenous protein inhibitor of the fucosyltransferase activities displays an opposite developmental pattern to that of fucosyltransferase activities, since its activity is high b

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Mohammed, Alaa, Nidal Mahdi, and Fakhri Ahmed. "Biochemical Estimation of Total Sialic Acid, Lipid-Bound Sialic Acid and Fucose in Serum Patients with Nasal and Paranasal Sinus Malignancies." Iraqi Journal of Medical Sciences 19, no. 2 (December 31, 2021): 137–46. http://dx.doi.org/10.22578/ijms.19.2.2.

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Background: It is known that measurement of serum total sialic acid (TSA), lipid bound sialic acid (LBSA) and L-Fucose levels may be altered and associated with different types of disease included malignant tumors, therefore, the evaluation of these compounds in serum cancer patients may elucidate the possibility of using this as a diagnostic marker. Objective: To explore the clinical application of TSA, LBSA and L-Fucose serum levels in patients with different site of nasal and para nasal sinus malignancies and compare with a group of healthy controls. Methods: Blood samples obtained from 16

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Kim, In Jung, and Kyoung Heon Kim. "l-Fucose Synthesis Using a Halo- and Thermophilic l-Fucose Isomerase from Polyextremophilic Halothermothrix orenii." Applied Sciences 12, no. 8 (April 15, 2022): 4029. http://dx.doi.org/10.3390/app12084029.

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l-Fucose isomerase (l-FucI)-mediated isomerization is a promising biotechnological approach for synthesizing various rare sugars of industrial significance, including l-fucose. Extremozymes that can retain their functional conformation under extreme conditions, such as high temperature and salinity, offer favorable applications in bioprocesses that accompany harsh conditions. To date, only one thermophilic l-FucI has been characterized for l-fucose synthesis. Here, we report l-FucI from Halothermothrix orenii (HoFucI) which exhibits both halophilic and thermophilic properties. When evaluated u

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Cai, Chao, Lihao Wang, Fei Fan, Haotian Wu, Lei Gao, Ping Zhang, Tiantian Sun, Chendong Yang та Guangli Yu. "Effect of Anomeric Configuration on Stereocontrolled α-Glycosylation of l-Fucose". Synlett 29, № 20 (23 листопада 2018): 2701–6. http://dx.doi.org/10.1055/s-0037-1611311.

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In this letter, we report an approach to the stereoselective α-glycosylation of l-fucose that is exemplified by effect of anomeric configuration. The neighboring group participation is not compatible with α-glycosylation of l-fucose, therefore the remote participation by 4-O-Bz was employed to control the formation of 1,2-cis-glycosidic bond. Furthermore, we found the anomeric configuration of fucose donor is crucial to stereoselectivity of the glycosylated products. The α/β-mixed products were generated by using β-anomeric donor while the glycosyl donor in α configuration yielded products in

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Mochimaru, Mari, Hajime Masukawa, Takashi Maoka, Hatem E. Mohamed, Wim F. J. Vermaas та Shinichi Takaichi. "Substrate Specificities and Availability of Fucosyltransferase and β-Carotene Hydroxylase for Myxol 2′-Fucoside Synthesis in Anabaena sp. Strain PCC 7120 Compared with Synechocystis sp. Strain PCC 6803". Journal of Bacteriology 190, № 20 (15 серпня 2008): 6726–33. http://dx.doi.org/10.1128/jb.01881-07.

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ABSTRACT To elucidate the biosynthetic pathways of carotenoids, especially myxol 2′-glycosides, in cyanobacteria, Anabaena sp. strain PCC 7120 (also known as Nostoc sp. strain PCC 7120) and Synechocystis sp. strain PCC 6803 deletion mutants lacking selected proposed carotenoid biosynthesis enzymes and GDP-fucose synthase (WcaG), which is required for myxol 2′-fucoside production, were analyzed. The carotenoids in these mutants were identified using high-performance liquid chromatography, field desorption mass spectrometry, and 1H nuclear magnetic resonance. The wcaG (all4826) deletion mutant o

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Pastuszak, Irena, Catherine Ketchum, Gary Hermanson, Eric J. Sjoberg, Richard Drake, and Alan D. Elbein. "GDP-l-fucose Pyrophosphorylase." Journal of Biological Chemistry 273, no. 46 (November 13, 1998): 30165–74. http://dx.doi.org/10.1074/jbc.273.46.30165.

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47

Thomas, Celestine J., and Avadhesha Surolia. "Mode of Molecular Recognition of l-Fucose by Fucose-Binding Legume Lectins." Biochemical and Biophysical Research Communications 268, no. 2 (February 2000): 262–67. http://dx.doi.org/10.1006/bbrc.2000.2110.

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Thomas, Celestine J., and Avadhesha Surolia. "Mode of Molecular Recognition of l-Fucose by Fucose-Binding Legume Lectins." Biochemical and Biophysical Research Communications 270, no. 1 (April 2000): 329. http://dx.doi.org/10.1006/bbrc.2000.2426.

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Litvinova, Ekaterina A., Victoria D. Bets, Natalya A. Feofanova, Olga V. Gvozdeva, Kseniya M. Achasova, Elizaveta L. Alperina, and Elena N. Kozhevnikova. "Dietary Fucose Affects Macrophage Polarization and Reproductive Performance in Mice." Nutrients 13, no. 3 (March 5, 2021): 855. http://dx.doi.org/10.3390/nu13030855.

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Intestinal mucus protects epithelial and immune cells from the gut resident microorganisms, and provides growth-promoting factors as mucus-derived O-glycans for beneficial bacteria. A lack of intestinal protective mucus results in changes in the commensal microflora composition, mucosal immune system reprogramming, and inflammation. Previous work has shown that fucose, the terminal glycan chain component of the intestinal glycoprotein Mucin2, and fucoidan polysaccharides have an anti-inflammatory effect in some mouse models of colitis. This study evaluates the effect of fucose on reproductive

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Kamble, Ashok S., Raj Kanthawar, and N. Vijayan. "Study of serum fucose level in breast malignancy." International Surgery Journal 6, no. 10 (September 26, 2019): 3749. http://dx.doi.org/10.18203/2349-2902.isj20194436.

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Background: Although for advanced tumour of breast have certain obvious physical characteristics, seldom is such physical finding seen in early malignant breast tumour. Keeping all these in mind, the present study aims at estimation of serum fucose which may help in early detection of breast malignancy.Methods: The present study was carried out over a period of one and a half year. A total of 68 patients were studied. Out of these 68 cases, 32 cases were having breast malignancy. After noting details history, through examination was done according to the proforma. Investigations were carried o

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