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Journal articles on the topic 'Fueling diagnosis'

Author: Grafiati

Published: 25 June 2021

Last updated: 29 July 2025

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1

Wight, Jared. "Fuelling the global supply of medical radioisotopes for cancer care." Open Access Government 45, no. 1 (2025): 236–37. https://doi.org/10.56367/oag-045-11731.

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Fuelling the global supply of medical radioisotopes for cancer care European research reactors play a crucial role in producing medical radioisotopes using nuclear fuel and are transitioning to Low Enriched Uranium (LEU) to meet non-proliferation commitments and global demand. Jared Wight tells us how he and his colleagues are working to ensure a smooth conversion to LEU fuels. Nuclear medicine is critical in the fight against cancer. It relies on research reactors to produce the medical isotopes needed for treatment and diagnosis. As part of a global effort to reduce security risks, many reac

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Maghimbi, Abubakar, Mtebe Majigo, Vincent Mashinji, George Loy, and Sekela Mwakyusa. "162 Challenges Fueling the Complexities of TB Diagnosis & TBHIV Comorbidity in Tanzania- IHV experience." JAIDS Journal of Acquired Immune Deficiency Syndromes 65 (April 2014): 70. http://dx.doi.org/10.1097/01.qai.0000446746.99602.a8.

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Hassannezhad, Reshad. "Hyperketonemia: Clinical features and diagnosis of Diabetic Ketoacidosis." Endocrinology and Disorders 2, no. 5 (2018): 01–04. http://dx.doi.org/10.31579/2640-1045/098.

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Diets that boost ketone production are increasingly used for treating several neurological disorders. Elevation in ketones in most cases is considered favorable, as they provide energy and are efficient in fueling the body's energy needs.Several physiological and pathological triggers, such as fasting, ketogenic diet, and diabetes cause an accumulation and elevation of circulating ketones. Complications of the brain, kidney, liver, and microvasculature were found to be elevated in diabetic patients who had elevated ketones compared to those diabetics with normal ketone levels. Diabetic ketoaci

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Hassannezhad, Reshad. "Hyperketonemia: Clinical features and diagnosis of Diabetic Ketoacidosis." Endocrinology and Disorders 2, no. 5 (2018): 01–04. http://dx.doi.org/10.31579/2640-1045/033.

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Diets that boost ketone production are increasingly used for treating several neurological disorders. Elevation in ketones in most cases is considered favorable, as they provide energy and are efficient in fueling the body's energy needs.Several physiological and pathological triggers, such as fasting, ketogenic diet, and diabetes cause an accumulation and elevation of circulating ketones. Complications of the brain, kidney, liver, and microvasculature were found to be elevated in diabetic patients who had elevated ketones compared to those diabetics with normal ketone levels. Diabetic ketoaci

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Cereser, Lorenzo, Laura Evangelista, Gianluca Giannarini, and Rossano Girometti. "Prostate MRI and PSMA-PET in the Primary Diagnosis of Prostate Cancer." Diagnostics 13, no. 16 (2023): 2697. http://dx.doi.org/10.3390/diagnostics13162697.

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Over the last years, prostate magnetic resonance imaging (MRI) has gained a key role in the primary diagnosis of clinically significant prostate cancer (csPCa). While a negative MRI can avoid unnecessary prostate biopsies and the overdiagnosis of indolent cancers, a positive examination triggers biopsy samples targeted to suspicious imaging findings, thus increasing the diagnosis of csPCa with a sensitivity and negative predictive value of around 90%. The limitations of MRI, including suboptimal positive predictive values, are fueling debate on how to stratify biopsy decisions and management b

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Miller, Mattea E., Ioan Lina, and Lee M. Akst. "Retrograde Cricopharyngeal Dysfunction: A Review." Journal of Clinical Medicine 13, no. 2 (2024): 413. http://dx.doi.org/10.3390/jcm13020413.

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Retrograde cricopharyngeal dysfunction (RCPD), also referred to as retrograde cricopharyngeus dysfunction, is a condition characterized by the inability to burp. The pathophysiology of this condition is thought to result from failure of cricopharyngeal sphincter relaxation during periods of esophageal distension, which leads to patients’ bothersome symptoms. RCPD negatively impacts patients’ quality of life and is associated with bloating, gurgling, avoidance of carbonation, self-imposed dietary and lifestyle changes designed to minimize discomfort, and flatulence. Complaints often start durin

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Riccardi, Niccolò, Sara Occhineri, Elisa Vanino, et al. "How We Treat Drug-Susceptible Pulmonary Tuberculosis: A Practical Guide for Clinicians." Antibiotics 12, no. 12 (2023): 1733. http://dx.doi.org/10.3390/antibiotics12121733.

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Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide and pulmonary TB (PTB) is the main variant responsible for fueling transmission of the infection. Effective treatment of drug-susceptible (DS) TB is crucial to avoid the emergence of Mycobacterium tuberculosis-resistant strains. In this narrative review, through a fictional suggestive case of DS PTB, we guide the reader in a step-by-step commentary to provide an updated review of current evidence in the management of TB, from diagnosis to post-treatment follow-up. World Health Organization and Centre for D

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Perneczky, Robert, and Alexander Kurz. "Dealing with uncertainty: biomarkers for the early detection of Alzheimer's disease." International Psychogeriatrics 24, no. 10 (2012): 1533–35. http://dx.doi.org/10.1017/s1041610212001056.

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In neuropsychiatric tradition, Alzheimer's disease (AD) is a clinical diagnosis that requires demonstration of a progressive memory-predominant type of dementia and exclusion of alternative causes. This simple set of criteria is neither sensitive for early clinical stages of AD since amnestic dementia only arises when the underlying neurodegeneration is fairly advanced, nor is it specific because it also occurs in other brain disorders involving the medial temporal lobe and cannot be easily distinguished from AD on clinical grounds. Efforts to identify AD before full-blown amnestic dementia de

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Sturm, Dominik, Stefan M. Pfister, and David T. W. Jones. "Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management." Journal of Clinical Oncology 35, no. 21 (2017): 2370–77. http://dx.doi.org/10.1200/jco.2017.73.0242.

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Gliomas are the most common CNS tumors in children and adolescents, and they show an extremely broad range of clinical behavior. The majority of pediatric gliomas present as benign, slow-growing lesions classified as grade I or II by the WHO classification of CNS tumors. These pediatric low-grade gliomas (LGGs) are fundamentally different from IDH-mutant LGGs occurring in adults, because they rarely undergo malignant transformation and show excellent overall survival under current treatment strategies. However, a significant fraction of gliomas develop over a short period of time and progress

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Loh, F. Ellen, and Shoshana J. Herzig. "Pain in the United States: Time for a Culture Shift in Expectations, Messaging, and Management." Journal of Hospital Medicine 14, no. 12 (2019): 787–88. http://dx.doi.org/10.12788/jhm.3277.

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Opioid prescribing has dramatically increased in the United States (US) over the past two decades, fueling the current crisis of opioid-related adverse events and deaths.1 Understanding the potential contributors to this increased prescribing is paramount to developing effective strategies for preventing propagation. In this issue of the Journal of Hospital Medicine, Burden et al. report the results of a cross-sectional observational study investigating the rates of opioid receipt, patient satisfaction with pain control, and other perceptions of pain management in a sample of patients from geo

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Pirri, Carmelo, Nina Pirri, Lucia Petrelli, Caterina Fede, Raffaele De Caro, and Carla Stecco. "An Emerging Perspective on the Role of Fascia in Complex Regional Pain Syndrome: A Narrative Review." International Journal of Molecular Sciences 26, no. 6 (2025): 2826. https://doi.org/10.3390/ijms26062826.

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Complex Regional Pain Syndrome (CRPS) is a debilitating pain disorder involving chronic inflammation, neural sensitization and autonomic dysfunction. Fascia, a highly innervated connective tissue, is increasingly recognized for its role in pain modulation, yet its contribution to CRPS remains underexplored. This narrative review synthesizes the current evidence on fascia’s involvement in CRPS pathophysiology and potential therapeutic strategies. A literature search was conducted in PubMed, Scopus and Web of Science, selecting studies on fascia, CRPS, inflammation, oxidative stress and autonomi

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Timis, Tanase, Sanda Buruiana, Delia Dima, et al. "Advances in Cell and Immune Therapies for Melanoma." Biomedicines 13, no. 1 (2025): 98. https://doi.org/10.3390/biomedicines13010098.

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The incidence rate of cutaneous melanoma is on the rise worldwide, due to increased exposure to UV radiation, aging populations, and exposure to teratogen agents. However, diagnosis is more precise, and the increased number of new cases is related to the improved diagnosis tools. Despite better early diagnosis and better therapies, melanoma has remained a significant public health challenge because of its aggressive behavior and high potential for metastasis. In 2020, cutaneous melanoma constituted approximately 1.3% of all cancer deaths that occurred within the European Union, thereby highlig

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Suzuki, Hiroyuki, Mary Vaughan-Sarrazin, Michael Ohl, et al. "Facility-Level Variation in Major Leg Amputation Among Patients With Newly Diagnosed Diabetic Foot Ulcer." JAMA Network Open 8, no. 4 (2025): e256781. https://doi.org/10.1001/jamanetworkopen.2025.6781.

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ImportanceThe prevalence of diabetes is increasing over time, fueling an epidemic of diabetic foot ulcers (DFUs) and subsequent risk of leg amputation. However, little is known about the variation in outcomes for patients with DFUs according to the health care facilities treating them.ObjectiveTo examine facility-level variation in major leg amputation among veterans with incident DFUs using the Veterans Health Administration (VHA) cohort.Design, Setting, and ParticipantsA retrospective cohort study was conducted from January 1, 2016, to December 31, 2021, of all veterans with a new diagnosis

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Khalifa, Maram, Hassaan B. Aftab, and Vitaly Kantorovich. "“Fueling the Fire” - Irish Sea-Moss Resulting in Jod-Basedow Phenomenon in a Patient With Grave’s Disease." Journal of the Endocrine Society 5, Supplement_1 (2021): A906. http://dx.doi.org/10.1210/jendso/bvab048.1849.

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Abstract Background: Jod-Basedow phenomenon is a rare cause of thyrotoxicosis due to excess iodine intake. Herbal supplements containing sea-moss have high iodine amount which may precipitate thyrotoxicosis in patients with underlying Grave’s disease or autonomous thyroid nodules. Clinical Case: A seemingly healthy 28-year-old female presented to the ED with chief complaint of fatigue with associated anxiety, palpitations and weight loss. On admission her temperature was 100.4 F, pulse 126 bpm and blood pressure 116/56 mmHg. Exam was unremarkable for thyroid goiter or orbitopathy. Labs reveale

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Sunil, Kumar Saxena, Singh Dangi Jitendra, Hajela Shalini, Kumar Dubey Ashish, and Pandey Smriti. "Retrospective Observational Study of Increasing Trend of Carcinoma Breast in Rural Region." International Journal of Pharmaceutical and Clinical Research 15, no. 3 (2023): 985–90. https://doi.org/10.5281/zenodo.12786935.

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<strong>Background: </strong>Breast cancer is a major global cause of illness and mortality. Breast cancer is still a serious public health problem despite improvements in diagnosis and treatment, especially in rural areas with limited access to medical facilities and screening program. <strong>Objective: </strong>This retrospective observational study aims to investigate the increasing trend of carcinoma breast in rural regions and identify factors contributing to this trend. <strong>Material& Method: </strong>Data were gathered from the medical records of individ

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Szygalowicz, Veronica. "Silent Struggles: Relative Energy Deficiency in Sport (REDs) in Female Athletes." Journal for Undergraduate Ethnography 15, no. 1 (2025): 45–63. https://doi.org/10.15273/jue.v15i1.12372.

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Relative Energy Deficiency in Sport (REDs) is a condition caused by prolonged periods of reduced energy intake relative to expenditure, specifically in sport. Although estimates of prevalence vary, most of the athletic population likely suffers from REDs. This interview-based project examined the state of REDs knowledge, awareness, and practices in female athletes and those working with them. Female athletes were the primary focus given their relative absence from existing research. Results from this project suggest that most cases of REDs are caused by unintentional nutrient restriction with

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Farahzadi, Raheleh, Mohammad Saeid Hejazi, Ommoleila Molavi, Elahe Pishgahzadeh, Soheila Montazersaheb, and Sevda Jafari. "Clinical Significance of Carnitine in the Treatment of Cancer: From Traffic to the Regulation." Oxidative Medicine and Cellular Longevity 2023 (August 10, 2023): 1–15. http://dx.doi.org/10.1155/2023/9328344.

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Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit metabolic flexibility to maintain high proliferation and survival rates. In other words, adaptation of cellular demand is essential for tumorigenesis, since a diverse supply of nutrients is required to accommodate tumor growth and progression. Diversity of carbon substrates fueling cancer cells indicate metabolic heterogeneity, even in tumors sharing the same clinical diagnosis. In addition to the alteration of glucose and amino acid metabolism in cancer cells, there is evidence that cancer cells can alter lipid

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Carriazo, Sol, Priscila Villalvazo, and Alberto Ortiz. "More on the invisibility of chronic kidney disease… and counting." Clinical Kidney Journal 15, no. 3 (2021): 388–92. http://dx.doi.org/10.1093/ckj/sfab240.

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ABSTRACT Lack of awareness of a diagnosis of chronic kidney disease (CKD) in patients and physicians is a major contributor to fueling the CKD pandemic by also making it invisible to researchers and health authorities. This is an urgent matter to tackle if dire predictions of future CKD burden are to be addressed. CKD is set to become the fifth-leading global cause of death by 2040 and the second-leading cause of death before the end of the century in some countries with long life expectancy. Coronavirus disease 2019 (COVID-19) illustrated this invisibility: only after the summer of 2020 did i

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Pierik, Annouk S., C. René Leemans, and Ruud H. Brakenhoff. "Resection Margins in Head and Neck Cancer Surgery: An Update of Residual Disease and Field Cancerization." Cancers 13, no. 11 (2021): 2635. http://dx.doi.org/10.3390/cancers13112635.

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Surgery is one of the mainstays of head and neck cancer treatment, and aims at radical resection of the tumor with 1 cm tumor-free margins to obtain locoregional control. Surgical margins are evaluated by histopathological examination of the resection specimen. It has been long an enigma that approximately 10–30% of surgically treated head and neck cancer patients develop locoregional recurrences even though the resection margins were microscopically tumor-free. However, the origins of these recurrences have been elucidated by a variety of molecular studies. Recurrences arise either from minim

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Lafta, Noor Abdalkareem. "A Comprehensive Analysis of Keras: Enhancing Deep Learning Applications in Network Engineering." Babylonian Journal of Networking 2023 (November 26, 2023): 94–100. https://doi.org/10.58496/bjn/2023/012.

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Python is currently one of the most popular programming languages that is used in the sector; it has surpassed many of its predecessors. There can be numerous reasons that make this programming language chosen by many developers – and much attention is paid to the availability of numerous libraries for various purposes. One of the major differences that Keras has when compared to other such libraries is the fact that it emphasises on usability according to the basic principles. First, Keras provides many options to choose from for deploying models in production, second, good performance is sup

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Ahmad, Nura M. R., Cristina Montañola-Sales, Clara Prats, Mustapha Musa, Daniel López, and Josep Casanovas-Garcia. "Analyzing Policymaking for Tuberculosis Control in Nigeria." Complexity 2018 (November 7, 2018): 1–13. http://dx.doi.org/10.1155/2018/9253846.

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Today, tuberculosis (TB) is still one of the major threats to humankind, being the first cause of death by an infectious disease worldwide. TB is a communicable chronic disease that every year affects 10 million people and kills almost 2 million people in the world. The main key factors fueling the disease are the progressive urbanization of the population and poverty-related socioeconomic factors. Moreover, the lack of effective tools for TB diagnosis, prevention, and treatment has decisively contributed to the lack of an effective model to predict TB spread. In Nigeria, the rapid urbanizatio

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Pan, Heng, Yanwen Jiang, David Redmond, et al. "Epigenomic Evolution In Diffuse Large B-Cell Lymphomas." Blood 122, no. 21 (2013): 634. http://dx.doi.org/10.1182/blood.v122.21.634.634.

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Abstract Diffuse Large B-cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma worldwide. It is a heterogeneous disease in which one third of patients either do not respond to treatment or relapse within five years after chemotherapy. It is unclear whether epigenetic alterations are responsible for B cell lymphomas relapse phenotypes, such as increased aggressiveness and chemoresistance. To investigate how the B cell lymphoma epigenome evolves upon chemotherapy, we used Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) to profile DNA methylation genome-wide in primary matche

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Ngo, Minh-Duc, Patrick Liang, and Samer Hussein. "A New Look into Ultrasound of the Facial and Subclavian Arteries in Patients Suspected with GCA: A Real-World Assessment." Journal of Rheumatology 52, Suppl 2 (2025): 108.1–108. https://doi.org/10.3899/jrheum.2025-0314.132.

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ObjectivesIn diagnosing giant cell arteritis (GCA), Canadian rheumatologists have extensive experience in using Doppler ultrasonography (US), fueling the debate about favoring it over the standard temporal artery biopsy. It remains unclear whether evaluating extracranial arteries in addition to temporal and axillary arteries significantly improves the diagnostic threshold.[1] The primary objective was to analyze the pattern of US abnormalities in GCA and test the benefit of adding facial and subclavian arteries in the GCA assessment. The secondary objective was to evaluate the effect of prior

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Kroshus, Emily, J. D. DeFreese, and Zachary Y. Kerr. "Collegiate Athletic Trainers' Knowledge of the Female Athlete Triad and Relative Energy Deficiency in Sport." Journal of Athletic Training 53, no. 1 (2018): 51–59. http://dx.doi.org/10.4085/1062-6050-52.11.29.

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Context: The female athlete triad (Triad) and relative energy deficiency in sport (RED-S) specify the consequences of energy imbalance. Athletic trainers (ATs) are positioned to identify athletes who are fueling themselves inadequately and experiencing related health and performance consequences. Objective: To assess the knowledge of collegiate ATs about the Triad and RED-S and to examine variability in related screening and referral behaviors among National Collegiate Athletic Association divisions. Design: Cross-sectional study. Setting: Collegiate athletic training departments. Patients or

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Mardis, Elaine R. "Abstract 1206: The molecular characterization initiative: Nationwide comprehensive clinical profiling of pediatric solid tissue malignancies at scale." Cancer Research 85, no. 8_Supplement_1 (2025): 1206. https://doi.org/10.1158/1538-7445.am2025-1206.

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Abstract The Molecular Characterization Initiative is an NCI-sponsored program being conducted in collaboration with the Children’s Oncology Group (COG), that seeks to enroll cancer patients from ages 0-25 with a primary diagnosis of a CNS malignancy, soft-tissue sarcoma, rare cancer or high-risk neuroblastoma onto Project Every Child. Subsequent to enrollment, the submission of a disease-involved specimen (cancer) and matched comparator normal (blood or buccal) is subjected to DNA and RNA (tumor) or DNA (normal) extraction by the Biopathology Center, followed by comprehensive clinical molecul

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Carrasqueira, L. M., M. D. Pereira, I. Marques, M. Silva, and C. Laureano. "Between Delusions and Borders: Diagnosing Delusional Disorder in Migratory Contexts." European Psychiatry 67, S1 (2024): S613. http://dx.doi.org/10.1192/j.eurpsy.2024.1276.

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Introduction The mental health of immigrants is a significant, yet often overlooked, aspect of public health. This case study highlights the intersection of migration and mental health, focusing on a patient with delusional disorder. It is particularly relevant for psychiatrists due to the unique challenges in diagnosing and treating mental health conditions in migrant populations, who often face cultural, linguistic, and systemic barriers in accessing care.ObjectivesThe primary objective of this case study is to elucidate the diagnostic and clinical challenges encountered in managing delusion

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D’Alessandro, Walmirton Bezerra, Sávia Denise Silva Carlotto Herrera, Fábio Pegoraro, et al. "The vision of biostatistics and biometrics on the analysis of biometric data: the Framingham risk score as an example." Revista de Gestão e Secretariado (Management and Administrative Professional Review) 14, no. 8 (2023): 12811–18. http://dx.doi.org/10.7769/gesec.v14i8.2569.

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The fields of Biostatistics and Biometrics play a crucial role in unraveling the mysteries of human health and empowering healthcare professionals to make informed decisions. By mining health data for meaningful patterns, they enable medical practitioners to identify emerging trends and develop targeted, effective policies and practices. Meanwhile, the analysis of biological data unleashes a wealth of insights, enabling accurate diagnoses and unleashing innovative therapies that transform lives. Together, these fields are a powerful force for good, fueling breakthroughs that enable us to bette

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Lahtinen, Alexandra, Giovanni Marchi, Kari Lavikka, et al. "Abstract PR003: DNA methylation reveals metastatic colonization routes in ovarian cancer." Cancer Research 85, no. 3_Supplement (2025): PR003. https://doi.org/10.1158/1538-7445.dnamethylation-pr003.

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Abstract High-grade serous carcinoma (HGSC) remains the deadliest gynecological cancer, mostly due to the widespread metastases in abdominal cavities already at diagnosis. To improve therapy success, understanding metastasis routes and their molecular characteristics is crucial. Herein, we used &gt;400 samples subjected to whole-genome bisulfite (WGBS) and RNA sequencing from 125 patients with HGSC, enrolled to prospective, longitudinal, multi-region, observational DECIDER trial (NCT04846933). These real-world epigenetics data allowed, for the first time, to delineate metastatic routes in

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Chen, T., and Y. Zhao. "AB0081 GLUTATHIONE PEROXIDASE 3 IS A NOVEL CLINICAL DIAGNOSTIC BIOMARKER AND POTENTIAL THERAPEUTIC TARGET FOR NEUTROPHILS IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1219.1–1219. http://dx.doi.org/10.1136/annrheumdis-2023-eular.16.

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BackgroundNeutrophils have a critical role in the pathogenesis of rheumatoid arthritis (RA) with immune system dysfunction. However, the molecular mechanisms of this process mediated by neutrophils still remain elusive.ObjectivesThe purpose of the present study is to identify hub genes in neutrophils for diagnosis and treatment of RA utilizing publicly available datasets.MethodsGene expression profiles were downloaded from the Gene Expression Omnibus and batch-corrected and normalized expression data were obtained using the ComBat package. Gene Ontology and Kyoto Encyclopedia of Genes and Geno

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Naidoo, Kogieleum, Rubeshan Perumal, Senamile L. Ngema, Letitia Shunmugam, and Anou M. Somboro. "Rapid Diagnosis of Drug-Resistant Tuberculosis–Opportunities and Challenges." Pathogens 13, no. 1 (2023): 27. http://dx.doi.org/10.3390/pathogens13010027.

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Global tuberculosis (TB) eradication is undermined by increasing prevalence of emerging resistance to available drugs, fuelling ongoing demand for more complex diagnostic and treatment strategies. Early detection of TB drug resistance coupled with therapeutic decision making guided by rapid characterisation of pre-treatment and treatment emergent resistance remains the most effective strategy for averting Drug-Resistant TB (DR-TB) transmission, reducing DR-TB associated mortality, and improving patient outcomes. Solid- and liquid-based mycobacterial culture methods remain the gold standard for

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Minyazeva, R. K., G. Y. Battalova, I. V. Sakhautdinova, and I. R. Gilyazova. "Genomic and Proteomic Markers of Cervical Cancer: a Prospective Outlook." Creative surgery and oncology 11, no. 2 (2021): 166–73. http://dx.doi.org/10.24060/2076-3093-2021-11-2-166-173.

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Gynaecological malignancy is a major challenge in women’s health worldwide. Cervical cancer (CC) is a particularly common type affecting the female reproductive system through an uncontrolled cell propagation causing cervical tissue injury in women. The advent of new technologies empowers research into the discovery and development of novel markers for early diagnosis, as well as therapy evaluation and monitoring. Despite manifold attempts to unravel the molecular mechanisms of CC, its pathogenesis remains largely unclear. The study of putative CC predictors is key to the invention of effectiv

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Bertani, Valeria, Olivier Blanck, Davy Guignard, Frederic Schorsch, and Hannah Pischon. "Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models." Toxicologic Pathology 50, no. 1 (2021): 23–34. http://dx.doi.org/10.1177/01926233211052010.

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Digital pathology has recently been more broadly deployed, fueling artificial intelligence (AI) application development and more systematic use of image analysis. Here, two different AI models were developed to evaluate follicular cell hypertrophy in hematoxylin and eosin-stained whole-slide-images of rat thyroid gland, using commercial AI-based-software. In the first, mean cytoplasmic area measuring approach (MCA approach), mean cytoplasmic area was calculated via several sequential deep learning (DL)-based algorithms including segmentation in microanatomical structures (separation of colloid

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Almakadi, Mohammed, Dalal Aldhafeeri, Amine Hameg, and Badr Aljoaid. "Acute Myeloid Leukemia with a Glossal Mass." Blood 144, Supplement 1 (2024): 5986. https://doi.org/10.1182/blood-2024-210757.

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Introduction Acute Myeloid Leukemia (AML) is an aggressive heterogeneous cancer of the bone marrow that stems from the unrestrained expansion of diseased hematopoietic cells coupled with a state of maturation arrest. Accounting for around 10% of cases, AML can manifest with extramedullary (EM) involvement. Common sites include soft tissues, skin, lymph nodes, and rarely the CNS. EM disease can be an additional risk for poor disease outcomes. Case Presentation A 37-year-old male was referred to our center as a case of acute leukemia. He had persistent fever, flu-like symptoms, and cervical lymp

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Greville-Harris, Maddy, Janet Smithson, and Anke Karl. "What are people’s experiences of orthorexia nervosa? A qualitative study of online blogs." Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 25, no. 6 (2019): 1693–702. http://dx.doi.org/10.1007/s40519-019-00809-2.

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Abstract Purpose Orthorexia nervosa (ON) is a proposed new eating disorder, used to describe a pathological obsession with healthy or ‘clean’ eating. Although some quantitative research has been carried out in ON, very little qualitative work has been published to date to explore individual experiences of ON. Thus, this study aimed to explore individuals’ personal experiences of ON, as described in online blogs. Methods Fifteen women bloggers, who self-identified as having ON, consented for their blog entries to be analysed in this study. Forty pre-existing blog entries describing the first-pe

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Kusunoki, Hiroshi. "Unraveling Rising Mortality: Statistical Insights from Japan and International Comparisons." Healthcare 13, no. 11 (2025): 1305. https://doi.org/10.3390/healthcare13111305.

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Since the onset of the COVID-19 pandemic, Japan has experienced a significant rise in mortality, with excess deaths surpassing historical projections. Statistical data indicate a sharp increase in mortality rates from 2021 onward, attributed to COVID-19, aging demographics, cardiovascular diseases, and malignancies. Preliminary 2024 data suggest continued excess mortality, fueling public debate. This review analyzes national and municipal mortality trends using official Japanese statistics and comparative data from South Korea, the U.S., and the EU. Findings reveal a sharp mortality rise post-

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Woods, Glynn. "Brucella canis: a clinical review and rationalising risk." In Practice 46, no. 3 (2024): 118–29. http://dx.doi.org/10.1002/inpr.416.

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Background: After a letter published by the chief veterinary officer in February 2021 highlighted an increase in the number of positive Brucella canis dogs, the frequency of B canis testing in the UK has increased substantially. To date, roughly 160 positive cases have been reported by the APHA. Amid growing unease, veterinary teams have implemented practice protocols to mitigate risk associated with this non‐endemic, zoonotic infection. Although well‐meaning, blanket policy and inappropriate application of serological tests can negatively impact client and patient welfare while fuelling healt

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P A, Asemota, Akinshipe B O, and Osaghae D O. "Profiling Discharge Against Medical Advice Among Paediatric Under-five Years Old: Experience From Igbinedion University Teaching Hospital, Nigeria." International Journal of Medical Science and Health Research 06, no. 02 (2022): 47–58. http://dx.doi.org/10.51505/ijmshr.2022.6206.

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Background: The increasing children (under-five years) morbidity and mortality rates in Nigeria is worrisome. Paediatric discharge against medical advice (P-DAMA) poses a particular challenge because under-age children lack autonomous power in their health decision-making, which may complicate their health problems. This study aimed at determining the prevalence of under-five P-DAMA and also to document its associated factors in Igbinedion University Teaching Hospital, Okada, Nigeria, with a view to curbing it. Methodology: This retrospective study reviewed all the admissions- and discharge- r

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Kazda, Luise, Katy Bell, Rae Thomas, Kevin McGeechan, and Alexandra Barratt. "Evidence of potential overdiagnosis and overtreatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents: protocol for a scoping review." BMJ Open 9, no. 11 (2019): e032327. http://dx.doi.org/10.1136/bmjopen-2019-032327.

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IntroductionWorldwide, attention deficit hyperactivity disorder (ADHD) diagnosis rates in children and adolescents have been increasing consistently over the past decades, fuelling a debate about the underlying reasons for this trend. While many hypothesise that a substantial number of these additional cases are overdiagnosed, to date there has been no comprehensive evaluation of evidence for or against this hypothesis. Thus, with this scoping review we aim to synthesise published evidence on the topic in order to investigate whether existing literature is consistent with the occurrence of ove

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Ahmed, Sharmeen, Shazia Rahim, Muhammad Faraz, and Syed Muhammad Hassan. "Emergence of Naegleria fowleri as a fatal parasite in Pakistan." Journal of the Pakistan Medical Association 74, no. 5 (2024): 1031–32. http://dx.doi.org/10.47391/jpma.10615.

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Madam, Naegleria fowleri, a life-threatening flagellate, causes a fulminating disease called Primary Amoebic Meningoencephalitis (PAM) which rapidly becomes fatal. The symptoms of PAM include headache, vomiting, stiff neck, seizures, and cerebral haemorrhages, eventually leading to death within 48 hours after the onset. The discovery of the first case of Naegleriasis in the US has led to considerable attention to research towards it. Since then, 39 other countries have fallen prey to the brain-eating parasite with Pakistan being the 2nd most affected country after the Southern US (1). Statisti

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Giermasz, Adam, Lloyd E. Damon, Lawrence D. Kaplan, et al. "Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy In Adults with Hematopoietic Disorders Undergoing Matched Unrelated Donor Stem Cell Transplantation." Blood 116, no. 21 (2010): 1317. http://dx.doi.org/10.1182/blood.v116.21.1317.1317.

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Abstract Abstract 1317 Introduction: Allogeneic stem cell transplantation offers potentially curative therapy for selected patients with hematopoietic malignancies or bone marrow failure states. Only 20–25% of transplantation candidates have compatible related donors, and thus the majority of patients require stem cells from unrelated individuals matching their human leukocyte antigen (HLA) genes. Unrelated donor transplantation (NMUDT) is associated with higher rate of acute and chronic graft versus host disease (aGVHD and cGVHD, respectively) resulting in significant treatment related morbid

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Katamba, Cibangu, Kandenge Wilhelmine, Kuume Josephina Miina, Mukendi Joseph Katuku, and Caprian Indileni Hikumwa. "Socio-demographic Characteristics of Tuberculosis Mortality in Grootfontein District, Namibia: analysis of hospital data between 2018 and 2022." Annales Africaines de Medecine 17, no. 3 (2024): e5674-e5684. http://dx.doi.org/10.4314/aamed.v17i3.9.

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Context and objective: Tuberculosis (TB) is ranked first killer among infectious diseases and listed among the top 10 causes of death worldwide. One of the factors fuelling TB epidemic is the global rise of multidrug resistant TB. The aim of this study was to describe the sociodemographic characteristics of TB mortality. Methods: This was a documentary series of TB cases recorded (using TB registers, TB cards, and medical files) and attended at Grootfontein District Hospital in Namibia between 2018 and 2022. Descriptive analysis of deaths assigned as caused by TB using ICD 10 was performed. Re

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"Fueling the passion for nursing." Nursing 47, no. 5 (2017): 6. http://dx.doi.org/10.1097/01.nurse.0000515513.71452.f3.

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Ansari, Shamshul, and Yoshio Yamaoka. "Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance." Clinical Microbiology Reviews, April 11, 2022. http://dx.doi.org/10.1128/cmr.00258-21.

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Despite the recent decrease in overall prevalence of Helicobacter pylori infection, morbidity and mortality rates associated with gastric cancer remain high. The antimicrobial resistance developments and treatment failure are fueling the global burden of H. pylori -associated gastric complications.

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Xie, Heying, Yin Jia, and Shanrong Liu. "Integration of artificial intelligence in clinical laboratory medicine: Advancements and challenges." Interdisciplinary Medicine, June 14, 2024. http://dx.doi.org/10.1002/inmd.20230056.

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AbstractArtificial intelligence (AI)‐driven analysis of comprehensive clinical parameters is bringing about a significant transformation in traditional routine clinical laboratory testing. This transformation impacts the prediction, prevention, diagnosis, and prognosis of human diseases. AI possesses the capability to efficiently analyze and process vast and intricate datasets, thereby facilitating the development of diverse and efficient diagnostic or predictive models. This advancement is fueling significant improvements in laboratory quality, automation, and the accuracy of diagnoses. In th

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Outeiro, Tiago F., Lorraine V. Kalia, Erwan Bezard, et al. "Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice." Movement Disorders, April 4, 2024. http://dx.doi.org/10.1002/mds.29802.

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AbstractBasic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel therapies and to establish the basis for personalized medicine. We conclude the viewpoint by a call to action to further improve interactions between clinician and basic scientists. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Mardis, Elaine R. "Pediatric Cancer Genetics and Genomics." Annual Review of Genomics and Human Genetics, May 28, 2025. https://doi.org/10.1146/annurev-genom-120823-010156.

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Molecular profiling of DNA and RNA from pediatric cancers by next-generation sequencing has been demonstrated to improve diagnosis and prognosis and to identify somatic alterations indicating vulnerability to targeted therapies. Hence, much like in the treatment of adult cancers, molecular profiling is now routinely utilized in clinical workflows for pediatric cancers as a companion to conventional pathology diagnosis. Many variants of unknown significance identified through DNA profiling are being characterized by saturation genome editing, enabled by CRISPR editing technology and clever func

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Westover, Jonathan. "The Downsides of "Don't Bring Me Problems, Bring Me Solutions": A Cautionary Note for Modern Leaders." Human Capital Leadership Review 13, no. 2 (2024). http://dx.doi.org/10.70175/hclreview.2020.13.2.12.

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This article examines the potential downsides of leaders telling their teams "don't bring me problems, bring me solutions." Through a review of relevant literature and a case study, it explores how this common directive can undermine informed decision-making, stifle creativity, and lead to superficial solutions. By discouraging open identification and analysis of issues, leaders risk missing critical information and opportunities for innovation. Alternative approaches are proposed that balance problem-focused discussion with solution orientation, such as establishing structured forums for conf

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Broos, Jelle Y., Rianne T. M. van der Burgt, Julia Konings, et al. "Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?" Journal of Neuroinflammation 21, no. 1 (2024). http://dx.doi.org/10.1186/s12974-023-02981-w.

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Abstract Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration. Considering the increasing prevalence among young adults worldwide and the disabling phenotype of the disease, a deeper understanding of the complexity of the disease pathogenesis is needed to ultimately improve diagnosis and personalize treatment opportunities. Recent findings suggest that bioactive lipid mediators (LM) derived from ω-3/-6 polyunsaturated fatty acids (PUFA), also termed eicosanoids, may contr

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Boyle, Dennis P., Santanu Banerjee, Ronald E. Bell та ін. "Extending the low-recycling, flat temperature profile regime in the Lithium Tokamak Experiment-β (LTX-β) with ohmic and neutral beam heating". Nuclear Fusion, 16 березня 2023. http://dx.doi.org/10.1088/1741-4326/acc4da.

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Abstract Recent experiments in the Lithium Tokamak Experiment-β (LTX-β) have extended the duration, performance, operating conditions, and diagnosis of the flat-temperature profile, low-recycling regime first observed in LTX. As expected, Li retains hydrogen and suppresses edge neutral cooling, allowing increased edge electron temperature, roughly equal to the core Te. Flat temperature profiles had been obtained transiently in LTX, as the plasma density decayed following the cessation of edge gas puffing. Careful control over the fueling in LTX-β has now been shown to sustain the flat Te profi

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Kieliszek, Agata M., Daniel Mobilio, Deepak Upreti, et al. "Intratumoral Delivery of Chimeric Antigen Receptor-T Cells Targeting CD133 Effectively Treats Brain Metastases." Clinical Cancer Research, October 3, 2023. http://dx.doi.org/10.1158/1078-0432.ccr-23-1735.

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Abstract Purpose: Brain metastases (BM) are mainly treated palliatively with an expected survival of less than 12 months post-diagnosis. In many solid tumors, the human neural stem cell marker glycoprotein CD133 is a marker of a tumor-initiating cell population that contributes to therapy resistance, relapse, and metastasis. Experimental design: Here, we use a variant of our previously described CD133 binder to generate second generation CD133-specific chimeric antigen receptor T cells (CAR-T) to demonstrate its specificity and efficacy against multiple patient-derived BM cell lines with varia

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