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Journal articles on the topic "Functional stimuli classes"

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Berg, Wendy K., David P. Wacker, Jay W. Harding, Jed Ganzer, and Anjali Barretto. "An evaluation of multiple dependent variables across distinct classes of antecedent stimuli pre and post functional communication training." Journal of Early and Intensive Behavior Intervention 4, no. 1 (2007): 305–33. http://dx.doi.org/10.1037/h0100346.

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Jefford, Michael, Max Schnurr, Tracey Toy, et al. "Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli." Blood 102, no. 5 (2003): 1753–63. http://dx.doi.org/10.1182/blood-2002-12-3854.

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AbstractDendritic cells (DCs) are a family of leukocytes that initiate T- and B-cell immunity against pathogens. Migration of antigen-loaded DCs from sites of infection into draining lymphoid tissues is fundamental to the priming of T-cell immune responses. In humans, the major peripheral blood DC (PBDC) types, CD1c+ DCs and interleukin 3 receptor–positive (IL-3R+) plasmacytoid DCs, are significantly expanded in vivo with the use of Flt3 ligand (FL). DC-like cells can also be generated from monocyte precursors (MoDCs). A detailed comparison of the functional potential of these types of DCs (in
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Digel, I., P. Kayser, and G. M. Artmann. "Molecular Processes in Biological Thermosensation." Journal of Biophysics 2008 (May 12, 2008): 1–9. http://dx.doi.org/10.1155/2008/602870.

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Since thermal gradients are almost everywhere, thermosensation could represent one of the oldest sensory transduction processes that evolved in organisms. There are many examples of temperature changes affecting the physiology of living cells. Almost all classes of biological macromolecules in a cell (nucleic acids, lipids, proteins) can present a target of the temperature-related stimuli. This review discusses some features of different classes of temperature-sensing molecules as well as molecular and biological processes that involve thermosensation. Biochemical, structural, and thermodynami
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Lee, In-Seon, Won-mo Jung, Hi-Joon Park, and Younbyoung Chae. "Spatial Information of Somatosensory Stimuli in the Brain: Multivariate Pattern Analysis of Functional Magnetic Resonance Imaging Data." Neural Plasticity 2020 (June 29, 2020): 1–9. http://dx.doi.org/10.1155/2020/8307580.

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Background. Multivoxel pattern analysis has provided new evidence on somatotopic representation in the human brain. However, the effects of stimulus modality (e.g., penetrating needle versus non-penetrating touch) and level of classification (e.g., multiclass versus binary classification) on patterns of brain activity encoding spatial information of body parts have not yet been studied. We hypothesized that performance of brain-based prediction models may vary across the types of stimuli, and neural patterns of voxels in the SI and parietal cortex would significantly contribute to the predicti
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Frank, M. E., S. L. Bieber, and D. V. Smith. "The organization of taste sensibilities in hamster chorda tympani nerve fibers." Journal of General Physiology 91, no. 6 (1988): 861–96. http://dx.doi.org/10.1085/jgp.91.6.861.

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Electrophysiological measurements of nerve impulse frequencies were used to explore the organization of taste sensibilities in single fibers of the hamster chorda tympani nerve. Moderately intense taste solutions that are either very similar or easily discriminated were applied to the anterior lingual surface. 40 response profiles or 13 stimulus activation patterns were considered variables and examined with multivariate statistical techniques. Three kinds of response profiles were seen in fibers that varied in their overall sensitivity to taste solutions. One profile (S) showed selectivity fo
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Ferrington, D. G., J. W. Downie, and W. D. Willis. "Primate nucleus gracilis neurons: responses to innocuous and noxious stimuli." Journal of Neurophysiology 59, no. 3 (1988): 886–907. http://dx.doi.org/10.1152/jn.1988.59.3.886.

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1. Recordings were made from 67 neurons in the nucleus gracilis (NG) of anesthetized macaque monkeys. All of the cells were activated antidromically from the ventral posterior lateral (VPL) nucleus of the contralateral thalamus. Stimuli used to activate the cells orthodromically were graded innocuous and noxious mechanical stimuli, including sinusoidal vibration and thermal pulses. 2. The latencies of antidromic action potentials following stimulation in the VPL nucleus were significantly shorter for cells in the caudal compared with the rostral NG. The mean minimum afferent conduction velocit
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Hibberd, Timothy J., Garreth R. Kestell, Melinda A. Kyloh, Simon J. H. Brookes, David A. Wattchow та Nick J. Spencer. "Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse". American Journal of Physiology-Gastrointestinal and Liver Physiology 310, № 8 (2016): G561—G573. http://dx.doi.org/10.1152/ajpgi.00462.2015.

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Spinal afferent neurons detect noxious and physiological stimuli in visceral organs. Five functional classes of afferent terminals have been extensively characterized in the colorectum, primarily from axonal recordings. Little is known about the corresponding somata of these classes of afferents, including their morphology, neurochemistry, and electrophysiology. To address this, we made intracellular recordings from somata in L6/S1 dorsal root ganglia and applied intraluminal colonic distensions. A transgenic calcitonin gene-related peptide-α (CGRPα)-mCherry reporter mouse, which enabled rapid
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SHIPP, STEWART, and SEMIR ZEKI. "The functional organization of area V2, I: Specialization across stripes and layers." Visual Neuroscience 19, no. 2 (2002): 187–210. http://dx.doi.org/10.1017/s0952523802191164.

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We used qualitative tests to assess the sensitivity of 1043 V2 neurons (predominantly multiunits) in anesthetised macaque monkeys to direction, length, orientation, and color of moving bar stimuli. Spectral sensitivity was additionally tested by noting ON or OFF responses to flashed stimuli of varied size and color. The location of 649 units was identified with respect to cycles of cytochrome oxidase stripes (thick-inter-thin-inter) and cortical layer. We used an initial 8-way stripe classification (4 stripes, and 4 “marginal” zones at interstripes boundaries), and a 9-way layer classification
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Medan, Violeta, Damián Oliva, and Daniel Tomsic. "Characterization of Lobula Giant Neurons Responsive to Visual Stimuli That Elicit Escape Behaviors in the Crab Chasmagnathus." Journal of Neurophysiology 98, no. 4 (2007): 2414–28. http://dx.doi.org/10.1152/jn.00803.2007.

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In the grapsid crab Chasmagnathus, a visual danger stimulus elicits a strong escape response that diminishes rapidly on stimulus repetition. This behavioral modification can persist for several days as a result of the formation of an associative memory. We have previously shown that a generic group of large motion-sensitive neurons from the lobula of the crab respond to visual stimuli and accurately reflect the escape performance. Additional evidence indicates that these neurons play a key role in visual memory and in the decision to initiate an escape. Although early studies recognized that t
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Bender, David A., Ruiye Ni, and Dennis L. Barbour. "Spontaneous activity is correlated with coding density in primary auditory cortex." Journal of Neurophysiology 116, no. 6 (2016): 2789–98. http://dx.doi.org/10.1152/jn.00474.2016.

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Sensory neurons across sensory modalities and specific processing areas have diverse levels of spontaneous firing rates (SFRs) in the absence of sensory stimuli. However, the functional significance of this spontaneous activity is not well-understood. Previous studies in the auditory system have demonstrated that different levels of spontaneous activity are correlated with a variety of physiological and anatomic properties, suggesting that neurons with differing SFRs make unique contributions to the encoding of auditory stimuli. Additionally, altered SFRs are a correlate of tinnitus, arising i
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Dissertations / Theses on the topic "Functional stimuli classes"

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Kassif-Weiss, Sivan O. "Do Shared S-minus Functions Among Stimuli Lead to Equivalence?" Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4863/.

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We examined the claim that equivalence classes contain all positive elements in a reinforcement contingency by asking whether negative stimuli in a reinforcement contingency will also form an equivalence class, based on their shared function as S-minus stimuli. In Experiment 1, 5 subjects were tested for equivalence for positive and negative stimuli. Testing of positive stimuli preceded testing of negative stimuli. Two of five subjects demonstrated equivalence for positive stimuli, and three subjects demonstrated equivalence for negative stimuli. In Experiment 2, order of testing was reversed.
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Canovas, Daniela de Souza. "Discriminações simples, classes funcionais e classes de equivalência." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-08102013-162058/.

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O presente estudo procurou investigar se procedimentos de discriminações simples, que produzem classes funcionais, poderiam produzir também classes de equivalência. No Experimento 1 utilizou-se o procedimento de discriminações simples sucessivas e reversões. Quatro adultos foram expostos ao treino em que respostas aos estímulos S+ (A1, B1 e C1), mas não aos S- (A2, B2 e C2), eram reforçadas. A seguir, os participantes eram expostos a reversões repetidas das contingências. Testes de relações condicionais emergentes (BA, CB, AC e CA) foram conduzidos por meio do procedimento go/no-go com estímul
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Machado, Alex Roberto. "Formação de classes funcionais de estímulos musicais." Universidade Federal do Espírito Santo, 2008. http://repositorio.ufes.br/handle/10/6674.

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Made available in DSpace on 2016-12-23T14:38:01Z (GMT). No. of bitstreams: 1 Dissertacao Alex Roberto Machado.pdf: 1288474 bytes, checksum: bfa93076c814a3f49c9b0c06fd320634 (MD5) Previous issue date: 2008-03-17<br>Uma abordagem comportamental da música considera a ação musical como comportamento e a música como estímulo, produto dessa ação. O objetivo geral aqui proposto foi o de verificar o efeito do treino discriminativo sobre a formação de classes funcionais de melodias em andamentos e modos diferentes. Participantes: 9 estudantes do segundo período da Graduação em Psicologia da Unilinhar
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Delgado, Diana. "Subsitution of stimulus functions as a means to distinguish among different types of functional classes /." abstract and full text PDF (free order & download UNR users only), 2005. http://0-wwwlib.umi.com.innopac.library.unr.edu/dissertations/fullcit/1430443.

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Thesis (M.A.)--University of Nevada, Reno, 2005.<br>"May, 2005." Includes bibliographical references (leaves 47-49). Online version available on the World Wide Web. Library also has microfilm. Ann Arbor, Mich. : ProQuest Information and Learning Company, [2005]. 1 microfilm reel ; 35 mm.
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Lobo, Harold E. "Complex stimulus control in humans merging functional and equivalence classes /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5938.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 83 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 71-74).
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MacIver, Kirsty. "The role of common stimulus functions in the development of equivalence classes." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4593/.

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College students were exposed to training designed to teach nine simple discriminations, such that sets of three arbitrary visual stimuli acquired common functions. For seven of eight participants, three 3-member contingency classes resulted. When the same stimuli were presented in a match-to-sample procedure under test conditions, four participants demonstrated equivalence-consistent responding, matching all stimuli from the same contingency class. Test performance for two participants was systematically controlled by other variables, and for a final participant was unsystematic. Exposure to
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Madrigal-Bauguss, Jessica Glenn Sigrid S. "Transfer of "good" and "bad" functions within stimulus equivalence classes." [Denton, Tex.] : University of North Texas, 2008. http://digital.library.unt.edu/permalink/meta-dc-6080.

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Madrigal-Bauguss, Jessica. "Transfer of "good" and "bad" functions within stimulus equivalence classes." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc6080/.

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This study compared results of two experiments that tested transfer of function in stimulus equivalence classes in a task dissimilar to (in Experiment I) and similar to (in Experiment II) the task that trained functional responding. Eleven students from UNT participated in return for monetary compensation. Phase 1 and 2 were identical in the two experiments, in which they established stimulus equivalence classes and functional responding, respectively. Each experiment then used different tasks in the third phase to test differential responding. Only participants in Experiment II demonstrated c
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Gomes, Dumas Pereira Ferreira. "Construindo funções de estímulo no desenvolvimento de autodiscriminação e de classes de estímulos equivalentes." Pontifícia Universidade Católica de São Paulo, 2010. https://tede2.pucsp.br/handle/handle/16883.

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Made available in DSpace on 2016-04-29T13:18:17Z (GMT). No. of bitstreams: 1 Dumas Pereira Ferreira Gomes.pdf: 525538 bytes, checksum: 5b068a1406d7f0e510275aa96a78ebaa (MD5) Previous issue date: 2010-05-06<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The first experiment of this study was conducted with 8 subjects and aimed to test if a simple discrimination procedure using contingency-specific responses was sufficient for the formation of equivalence classes. After a discrimination training with 3 distinct responses emitted to 3 sets of 3 stimuli, tests for equivalenc
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Montans, Maria Paula Soares. "A emergência de relações condicionais entre estímulos como resultado de treino de pares de discriminações simples simultâneas." Pontifícia Universidade Católica de São Paulo, 2006. https://tede2.pucsp.br/handle/handle/16769.

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Made available in DSpace on 2016-04-29T13:17:58Z (GMT). No. of bitstreams: 1 MariaPaulaMontans.pdf: 976390 bytes, checksum: 501a51586442d57ea969b712b2f444c6 (MD5) Previous issue date: 2006-05-10<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Stimulus and response classes are defined by a given set of shared properties. Stimulus classes are identified when different stimuli affect an organism in the same way. Processes, procedures and variables responsible for the establishment of stimulus control and stimulus classes and for the testing of such classes have been studied
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Books on the topic "Functional stimuli classes"

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Verstraten, Frans A. J., and Peter J. Bex. The Motion Aftereffect. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199794607.003.0082.

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The aftereffect of motion is one of the oldest known illusions. It refers to the illusory motion of a stationary scene after some time of adaptation to real motion. While it is still unknown whether this adaptation effect has any functional value, it surely has served well as a tool to investigate the functional organization of the visual system. In this chapter some of the classic findings are discussed. More recent work using complex stimuli, attentional modulation, higher order motion, as well as modern neuro-imaging techniques has provided vision scientists with surprising new insights. Di
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Kearney, Christopher A., and Anne Marie Albano. When Children Refuse School. Oxford University Press, 2018. http://dx.doi.org/10.1093/med-psych/9780190604059.001.0001.

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Problematic school absenteeism is the primary focus of When Children Refuse School: A Cognitive-Behavioral Therapy Approach, Therapist Guide. Youths who complete high school are more likely to experience greater success at social, academic, occupational, and economic aspects of functioning than youths who do not. Youths with problematic school absenteeism are at risk for lower academic performance and achievement, lower reading and mathematics test scores, fewer literacy skills, internalizing and externalizing behavior problems, grade retention, involvement with the juvenile justice system, an
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Book chapters on the topic "Functional stimuli classes"

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Koch, Christof. "Bursting Cells." In Biophysics of Computation. Oxford University Press, 1998. http://dx.doi.org/10.1093/oso/9780195104912.003.0022.

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Some neurons throughout the animal kingdom respond to an intracellular current injection or to an appropriate sensory stimulus with a stereotypical sequence of two to five fast spikes riding upon a slow depolarizing envelope. The entire event, termed a burst, is over within 10-40 msec and is usually terminated by a profound afterhyperpolarization (ΑΗΡ). Such bursting cells are not a random feature of a certain fraction of all cells but can be identified with specific neuronal subpopulations. What are the mechanisms generating this intrinsic firing pattern and what is its meaning? Bursting cells can easily be distinguished from a cell firing at a high maintained frequency by the fact that bursts will persist even at a low firing frequency. As illustrated by the thalamic relay cell of Fig. 9.4, some cells can switch between a mode in which they predominantly respond to stimuli via single, isolated spikes and one in which bursts are common. Because we believe that bursting constitutes a special manner of signaling important information, we devote a single, albeit small chapter to this topic. In the following, we describe a unique class of cells that frequently signal with bursts, and we touch upon the possible biophysical mechanisms that give rise to bursting. We finish this excursion by focussing on a functional study of bursting cells in the electric fish and speculate about the functional relevance of burst firing. Neocortical cells are frequently classified according to their response to sustained current injections. While these distinctions are not all or none, there is broad agreement for three classes: regular spiking, fast spiking, and intrinsically bursting neurons (Connors, Gutnick, and Prince, 1982; McCormick et al., 1985; Connors and Gutnick, 1990; Agmon and Connors, 1992; Baranyi, Szente, and Woody, 1993; Nuńez, Amzica, and Steriade, 1993; Gutnick and Crill, 1995; Gray and McCormick, 1996). Additional cell classes have been identified (e.g., the chattering cells that fire bursts of spikes with interburst intervals ranging from 15 to 50 msec; Gray and McCormick, 1996), but whether or not they occur widely has not yet been settled. The cells of interest to us are the intrinsically bursting cells.
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Bonabeau, Eric, Marco Dorigo, and Guy Theraulaz. "Nest Building and Self-Assembling." In Swarm Intelligence. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780195131581.003.0010.

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Social insect nest architectures can be complex, intricate structures. Stigmergy (see section 1.2.3), that is, the coordination of activities through the environment, is an important mechanism underlying nest construction in social insects. Two types of stigmergy are distinguished: quantitative, or continuous stigmergy, in which the different stimuli that trigger behavior are quantitatively different; and qualitative, or discrete stigmergy, in which stimuli can be classified into different classes that differ qualitatively. If quantitative stigmergy can explain the emergence of pillars in termites, the building behavior of the paper wasps Polistes dominulus seems to be better described by qualitative stigmergy. In this chapter, a simple agent-based model inspired by discrete stigmergy is introduced. In the model, agents move in a three-dimensional grid and drop elementary building blocks depending on the configuration of blocks in their neighborhood. From the viewpoint of bricks, this model is a model of self-assembly. The model generates a large proportion of random or space-filling forms, but some patterns appear to be structured. Some of the patterns even look like wasp nests. The properties of the structured shapes obtained with the model, and of the algorithms that generate them, are reviewed. Based on these properties, a fitness function is constructed so that structured architectures have a large fitness and unstructured patterns a small fitness. A genetic algorithm based on the fitness function is used to explore the space of architectures. Several examples of self-assembling systems in robotics, engineering, and architecture are described. Self-assembling or self-reconfigurable robotic systems, although they are not directly inspired by nest construction in social insects, could benefit from the discrete-stigmergy model of nest building. The method of evolutionary design, that is, the creation of new designs by computers using evolutionary algorithms, is a promising way of exploring the patterns that self-assembling models can produce. Many animals can produce very complex architectures that fulfill numerous functional and adaptive requirements (protection from predators, substrate of social life and reproductive activities, thermal regulation, etc.).
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Dougher, Michael J., and Michael R. Markham. "8 Stimulus classes and the untrained acquisition of stimulus functions." In Advances in Psychology. Elsevier, 1996. http://dx.doi.org/10.1016/s0166-4115(06)80107-x.

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Sunday Nnamchi, Paul, and Camillus Sunday Obayi. "Self-Healing in Titanium Alloys: A Materials Science Perspective." In Advanced Functional Materials. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92348.

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Self-healing materials (SHM’s) is an emerging class of smart materials, which are capable of autonomous or spontaneous repair of their damage under external stimuli, such as heat, light, and solvent, to the original or near original functionalities much like the biological organisms. The emergence of self-healing in metallic materials presents an exciting paradigm for an ideal combination of metallic and biological properties. The driving force behind this effort is to decrease the consequences of accidents, reduction of cost and extending the service life of metallic components. While previous reviews have focused on self-healing in polymers, composite, concrete and cementous materials, and ceramic, discussions about self-healing in metallic materials remains scarce and the survey of literatures suggests Ti-based self-healing materials known to be biocompatible in human body is rare. The present chapter examines the art of self-healing in titanium-based alloys with the scope to provide an overview of recent advancements and to highlight current problems and perspectives with respect to potential application.
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Kumar Singh, Mukesh. "Textiles Functionalization - A Review of Materials, Processes, and Assessment." In Textiles for Functional Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96936.

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Conventionally, textiles are known to cover up the human skin, but by scientific administration, clothing can be extended to serve other human skins’ functions. Accepting the chemical and dermatological complexity of human skin, the effect of humidity, microbes, pH, temperature, and wind can be engineered by wrapping it by functional clothing. In this regard, the latest class of textile material has been added called functional textiles. Such clothing materials consist of the potential of delivering more than one functionality apart from its primary function to coverups the human body. This present chapter offers state-of-the-art viewpoints on the application of functional textiles, including assorted concerns. First, the skin responds to various environmental stimuli and then overviews various techniques to incorporate functionalities in textiles. Finally, the applications and future scope and possibilities of research in this field are included in this chapter. Miniaturisation to small micro to nanometre scale is registered as one of the most exciting meadows in engineering and science over the past few decades. This drift also grasps colossal potential to functionalise the textiles. Various techniques are available now to develop a thin uniform film of functional materials on clothing surface to offer extra functionalities hitherto unrevealed to textile processors. These technologies are based on layer-by-layer assembling, immobilisation of enzymes on textile surfaces, nanocoating of textile substances, plasma for nanoscale modifications, and loading of various functional biomaterials micro and nanoencapsulation by minimum influence on breathability, feel, handle, and strength. The manufacturing of functional textiles can be classified into two groups. One is to functionalise the fibre by adding dope additives, modifying the fibre forming polymer, and then converting it to clothing. The fibre surface is also functionalised by adding some resins on the fibre surface. The other is to modify the textile surfaces by functional biomaterials, resins, finishes.
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Postle, Bradley R. "Cognitive Neuroscience of Visual Working Memory." In Working Memory. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198842286.003.0012.

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This chapter takes the perspective that ‘working memory’ refers to a class of behaviours that can be accomplished by the coordinated recruitment of sensory-, representational-, action-, and control-related mechanisms and representations. There is no working memory system, per se. This idea is illustrated with findings from cognitive neuroscience, with an emphasis on studies of human working memory with functional magnetic resonance imaging and electroencephalography, and on simulations of human behaviour with recurrent neural network modelling. Understanding principles of attention and oculomotor control are central to understanding the selection of stimulus information and its retention ‘in’ working memory, as well as for the moment-to-moment prioritization of subsets of the contents of working memory. Recent research from a dynamical systems perspective suggests a principled framework for understanding how, and under what circumstances, knowledge from long-term memory is recruited to support working memory performance. An important challenge for contemporary cognitive neuroscience is to develop an accepted procedure for assessing when multiple regions can be shown to represent stimulus-specific information, whether these regions are all supporting the same function, or perhaps different functions that nonetheless all entail the active representation of the same information.
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Kumar Pradhan, Lagen, and Manoranjan Kar. "Relaxor Ferroelectric Oxides: Concept to Applications." In Multifunctional Ferroelectric Materials. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96185.

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Ferroelectric ceramic is one of the most important functional materials, which has great importance in modern technologies. A ferroelectric ceramic simultaneously exhibits dielectric, piezoelectric, ferroelectric, and pyroelectric properties. The inherent ferroelectric properties are directly related to long-range electric dipoles arrangement in the ferroelectric domains and its response to external stimuli. However, the interruption of the long-range ordering of dipoles leads to the formation of a special class of material is known as relaxor ferroelectric. It shows quite different physical properties as compared to ferroelectric (normal ferroelectric). The origin and design of relaxor ferroelectric are quite interesting for fundamental perspective along with device applications. Therefore, the origin of relaxor ferroelectric along with its fundamental understanding for possible future applications, have been explained briefly in the present chapter.
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Hanahan, Donald J. "Introduction to Lipids." In A Guide to Phospholipid Chemistry. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195079814.003.0004.

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Concomitant with the explosive development and progress made in the field of molecular biology, initiated by development and proof of the double helix structure of DNA some 40 years ago, there has been a much more subdued, but equally exciting and important, development in the area of signal transduction (Nishizuka, 1992; Berridge, 1984; Exton, 1990). What makes the latter subject so enchanting to biochemists is the finding that membrane phospholipids are intimately involved in the transduction process. Interestingly, the potential role of phospholipids in the signal transduction pathway was formulated some 40 years ago also. (Perhaps all great discoveries occur in 40 year cycles.) In any event the first hint of any possible involvement of phospholipids in cellular stimulus responses was gained from the work of Hokin and Hokin, which first appeared in 1953. In this classic paper, these investigators reported that treatment of pigeon pancreas slices with acetylcholine or carbamylcholine (cholinergic drugs) resulted not only in the secretion of amylases but also in the turnover of two specific membrane phospholipids, namely, phosphatidylinositol and phosphatidic acid. While the entire process of stimulus response in a mammalian cell is now much more complicated, nevertheless the findings by Hokin and Hokin were of major importance in the maturation of this field. Unfortunately, the impact of the Hokins’ observations was not immmediately felt. At that point in time, phospholipids were viewed mainly as semipermeable membrane structures whose main function was to regulate the ion content of the cell. In addition, another deterrent was the limited information on the chemical structure of the mammalian cell phospholipids. Hence there was a hiatus of many years in which low-profile lipid chemists and biochemists labored to solve the chemical nature of membrane lipids and to deduce their physical arrangement in the cell. Then in 1975, Michell published a key paper (Michell, 1975) in which he noted the importance of the inositol-containing phospholipids in the membrane process known as calcium gating. This paper initiated what can be called the “PI” era, which is still very much alive and well today.
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Conference papers on the topic "Functional stimuli classes"

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Brei, Diann. "Nexus Materials: A Vision Just Beyond the Horizon." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-15216.

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In future applications, materials will need to extend beyond that of the bulk response or even simple engineered behavior. This paper attempts to articulate an integrated vision and even push it further to the next realm of materials defined here as Nexus materials, the synergistic connection that weaves it all together. The applications in mind will demand complex functionality such as higher order actuation across surfaces/volumes, distributed conformal sensing, and full-spectrum instantaneous color change. Looking beyond the horizon, the level of complexity needs to be raised to radical sta
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Orosz, Ga´bor, Jeff Moehlis, and Francesco Bullo. "Delayed Car-Following Dynamics for Human and Robotic Drivers." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-48829.

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A general class of car-following models is analyzed where the longitudinal acceleration of a vehicle is determined by a nonlinear function of the distance to the vehicle in front, their velocity difference, and the vehicle’s own velocity. The driver’s response to these stimuli includes the driver reaction time that appears as a time delay in governing differential equations. The linear stability of the uniform flow is analyzed for human-driven and computer-controlled (robotic) vehicles. It is shown that the stability conditions are equivalent when considering ring-road and platoon configuratio
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Beblo, Richard V., and Lisa Mauck Weiland. "Using Multiscale Modeling to Predict Material Response of Polymeric Materials." In ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2009. http://dx.doi.org/10.1115/smasis2009-1333.

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Presented is a multiscale modeling method applied to light activated shape memory polymers (LASMP). LASMP are a new class of shape memory polymer (SMP) being developed for applications where a thermal stimulus is undesired. Rotational Isomeric State (RIS) theory is used to build a molecular scale model of the polymer chain yielding a list of distances between the predicted cross-link locations, or r-values. The r-values are then fit with Johnson probability density functions and used with Boltzmann statistical mechanics to predict stress as a function of strain of the phantom network. Junction
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Nguyen, Mary-Anne, Nima Tamaddoni, and Stephen A. Sarles. "Interrogation of Bilayers in a Multi-Droplet Cluster for Membrane-Based Sensing." In ASME 2015 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/smasis2015-8970.

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The long-term vision of our work is to create a new class of smart material that utilizes networks of active, synthetic cell membranes for sensing, actuation, and energy harvesting. Having multiple membrane structures is specifically targeted because a higher density of functional membranes is expected to enable amplification and collective utility, similar to how living tissues and organisms utilize networks of highly connected cells to accomplish large tasks. While there are several known methods for assembling droplet-based networks of synthetic lipid bilayers, there has been much less effo
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He, Xingxi, and Donald J. Leo. "Monte-Carlo Simulation of Ion Transport at the Polymer-Metal Interface." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79765.

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The transport of charge due to electric stimulus is the primary mechanism of actuation for a class of polymeric active materials known as ionomeric polymer transducers. Continuum-based models of ion transport have been developed for the purpose of understanding charge transport due to diffusion and migration. In this work a two dimensional ion hopping model has been built to describe ion transport in ionomeric polymer transducer (IPT) with Monte-Carlo simulation. In the simulation, cations are distributed on 50nm × 50nm × 1nm (or 50nm × 10 nm × 1nm) lattice cells of IPT while the same number o
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