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Journal articles on the topic 'Functional tics'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Ganos, Christos, Roberto Erro, Andrea E. Cavanna, and Kailash P. Bhatia. "Functional tics and echophenomena." Parkinsonism & Related Disorders 20, no. 12 (2014): 1440–41. http://dx.doi.org/10.1016/j.parkreldis.2014.10.001.

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Mendonça, Vanessa. "Tics, Functional Tics, TikTok and COVID-19: A Pediatric Case Report." Sinapse 22, no. 3 (2022): 127–31. http://dx.doi.org/10.46531/sinapse/cc/220007/2022.

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3

Goldman, Kissel J., and Iser G. DeLeon. "A Review on Functional Analyses of Tics." Behavior Modification 44, no. 2 (2018): 296–315. http://dx.doi.org/10.1177/0145445518809046.

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Tic disorders are characterized by a class of responses assumed to be neurobiological in origin. Still, several studies have shown that tic frequency can be influenced by antecedent environmental events and social consequences. Prior reviews have summarized the effects of environmental events but have not examined relations between tic diagnosis, behavioral deficits (e.g., intellectual disability), tic topography, and the consequences observed to maintain tics. These variables might be important when attempting to predict or identify relevant consequences. A more thorough understanding of the

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Malaty, Irene A., Seonaid Anderson, Shannon M. Bennett, et al. "Diagnosis and Management of Functional Tic-Like Phenomena." Journal of Clinical Medicine 11, no. 21 (2022): 6470. http://dx.doi.org/10.3390/jcm11216470.

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Over the past 3 years, a global phenomenon has emerged characterized by the sudden onset and frequently rapid escalation of tics and tic-like movements and phonations. These symptoms have occurred not only in youth known to have tics or Tourette syndrome (TS), but also, and more notably, in youth with no prior history of tics. The Tourette Association of America (TAA) convened an international, multidisciplinary working group to better understand this apparent presentation of functional neurological disorder (FND) and its relationship to TS. Here, we review and summarize the literature relevan

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Demartini, Benedetta, Lucia Ricciardi, Isabel Parees, Christos Ganos, Kailash P. Bhatia, and Mark J. Edwards. "A POSITIVE DIAGNOSIS OF FUNCTIONAL (PSYCHOGENIC) TICS." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 9 (2015): e3.55-e3. http://dx.doi.org/10.1136/jnnp-2015-311750.59.

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Demartini, B., L. Ricciardi, I. Parees, C. Ganos, K. P. Bhatia, and M. J. Edwards. "A positive diagnosis of functional (psychogenic) tics." European Journal of Neurology 22, no. 3 (2014): 527—e36. http://dx.doi.org/10.1111/ene.12609.

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7

Tan, Eng-King. "Psychogenic Tics: Diagnostic Value of the Placebo Test." Journal of Child Neurology 19, no. 12 (2004): 976–77. http://dx.doi.org/10.1177/088307380401901201.

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Motor tics are characterized by abrupt onset of brief, unsustained focal movements that are usually preceded by a premonitory sensation and are suppressible. Psychogenic tics (pseudotics) are rarely described. It may not be easy to distinguish organic from functional tics because they can coexist. Using a case illustration, the value of a “staged” placebo test in aiding the diagnosis of psychogenic tics is described. In addition, a concise summary of the clinical phenomenology of tics and the diagnosis and management of psychogenic movement disorders is provided. (J Child Neurol 2004;19:976-97

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Andersen, Kaja, Ida Jensen, Kirstine Birkebæk Okkels, Liselotte Skov, and Nanette Mol Debes. "Clarifying the Differences between Patients with Organic Tics and Functional Tic-Like Behaviors." Healthcare 11, no. 10 (2023): 1481. http://dx.doi.org/10.3390/healthcare11101481.

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Due to the global increase in the number of patients with Functional Tic-Like Behaviors (FTLB), it has become increasingly important to find reliable differences between this patient group and patients with organic tics (OTs), which can be used in differential diagnosis. The purpose of this retrospective study was to critically examine both established and suggested differences between the patient groups. A total of 53 FTLB patients and 200 OT patients were included. Several findings from the current literature were replicated in this study: Compared to patients with OTs, patients with FTLB ha

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Millichap, J. Gordon. "Neural Basis of Tics: A Functional MRI Study." Pediatric Neurology Briefs 20, no. 9 (2006): 69. http://dx.doi.org/10.15844/pedneurbriefs-20-9-6.

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10

Stern, Emily, David A. Silbersweig, Kit-Yun Chee, et al. "A Functional Neuroanatomy of Tics in Tourette Syndrome." Archives of General Psychiatry 57, no. 8 (2000): 741. http://dx.doi.org/10.1001/archpsyc.57.8.741.

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Carr, James E., Tina M. Sidener, David W. Sidener, and Anne R. Cummings. "Functional analysis and habit-reversal treatment of tics." Behavioral Interventions 20, no. 3 (2005): 185–202. http://dx.doi.org/10.1002/bin.193.

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12

Nagy, Péter, Helga Cserháti, Beáta Rosdy, et al. "TikTok and tics: the possible role of social media in the exacerbation of tics during the COVID lockdown." Ideggyógyászati szemle 75, no. 5-6 (2022): 211–16. http://dx.doi.org/10.18071/isz.75.0211.

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Over the past year, many cases with newly onset or significantly exacerbated tic disorders were observed worldwide, where some aspects of the clinical presentation or the symptomatology were atypical for established tic diagnoses. Our purpose was to describe the atypical cases and raise relevant diagnostic issues. Consecutive cases with atypical tic presentations were documented. Five atypical tic cases are described. These cases shared some common characteristics, most notably the fact that all of them had been exposed to online presentation of ticking behaviour on social media platforms prio

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ALKAN, YELDA, BHARAT B. BISWAL, PAUL A. TAYLOR, and TARA L. ALVAREZ. "Segregation of frontoparietal and cerebellar components within saccade and vergence networks using hierarchical independent component analysis of fMRI." Visual Neuroscience 28, no. 3 (2011): 247–61. http://dx.doi.org/10.1017/s0952523811000125.

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AbstractPurpose: Cortical and subcortical functional activity stimulated via saccade and vergence eye movements were investigated to examine the similarities and differences between networks and regions of interest (ROIs). Methods: Blood oxygenation level-dependent (BOLD) signals from stimulus-induced functional Magnetic Resonance Imaging (MRI) experiments were analyzed studying 16 healthy subjects. Six types of oculomotor experiments were conducted using a block design to study both saccade and vergence circuits. The experiments included a simple eye movement task and a more cognitively deman

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Souto, Eric, Ping Gong, John Landua, et al. "Abstract PO5-24-02: Interferon-induced bone marrow stromal antigen 2 (BST2) is a functional tumor-initiating cell marker in triple-negative breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO5–24–02—PO5–24–02. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-24-02.

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Abstract Background: A subpopulation of tumor cells known to have intrinsic resistance to therapies and contribute to metastasis function as “cancer stem”, or tumor-initiating, cells (TICs). TICs can be identified by various biomarkers, including fluorescent reporters for signaling pathways that regulate TIC function such as STAT signaling. However, standard TIC reporters have limitations. Their expression is unstable and there is no established method to follow TICs as they undergo cell state changes. Furthermore, we do not completely understand the transcriptional features of TICs. Improved

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Gagnon, Méliza, Ilana Singer, Simon Morand-Beaulieu, et al. "Sex Differences in Youth with Chronic Tic Disorder and Tourette Syndrome: Evaluation of Tic Severity, Psychological Profiles, and Quality of Life." Journal of Clinical Medicine 13, no. 9 (2024): 2477. http://dx.doi.org/10.3390/jcm13092477.

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Background: Tourette syndrome (TS) and Chronic Tic Disorder (CT) are neurodevelopmental conditions involving motor and/or phonic tics. Youth with tics may encounter feelings of isolation, diminished self-esteem and quality of life, and academic difficulties. A growing body of scientific literature suggests sex differences in youth with tics, but findings have been mixed so far. Because symptom severity peaks around puberty, understanding sex differences in tic manifestations and associated symptoms during this critical period is essential. Therefore, we aimed to assess sex differences related

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Cavanna, Andrea Eugenio, Laura Spini, Silvia Ferrari, et al. "Functional Tic-like Behaviors: From the COVID-19 Pandemic to the Post-Pandemic Era." Healthcare 12, no. 11 (2024): 1106. http://dx.doi.org/10.3390/healthcare12111106.

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During the COVID-19 pandemic, there have been multiple reports about an unforeseen surge in adolescents and young adults exhibiting sudden onset functional tic-like behaviors. This phenomenon has been mainly associated with the female gender and occasionally after exposure to social media content featuring similar patterns of functional tic-like behaviors. A significant portion of these individuals have been directed to specialist clinics for movement disorders with initial misdiagnoses of late-onset refractory Tourette syndrome. Distinguishing between rapid onset functional tic-like behaviors

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Vial, Felipe, Sanaz Attaripour, and Mark Hallett. "Differentiating tics from functional (psychogenic) movements with electrophysiological tools." Clinical Neurophysiology Practice 4 (2019): 143–47. http://dx.doi.org/10.1016/j.cnp.2019.04.005.

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Cavanna, AndreaE, Giulia Purpura, and Renata Nacinovich. "Neurodevelopmental versus functional Tics: The state of the art." Archives of Medicine and Health Sciences 10, no. 2 (2022): 239. http://dx.doi.org/10.4103/amhs.amhs_246_22.

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19

Storch, Eric A., Jessica E. Morgan, Nicole E. Caporino, et al. "Psychosocial Treatment to Improve Resilience and Reduce Impairment in Youth With Tics: An Intervention Case Series of Eight Youth." Journal of Cognitive Psychotherapy 26, no. 1 (2012): 57–70. http://dx.doi.org/10.1891/0889-8391.26.1.57.

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Background: Many youth with tic disorders experience distress about having tics and how others may perceive them. Such symptoms are often more impairing and distressing than the tics themselves and negatively impact self-concept, psychosocial functioning, and quality of life. Objective: Although there exist pharmacological and behavioral treatments that target the frequency and severity of tics, no intervention has been developed specifically to help youth with tics cope with their condition and limit associated functional impairment and distress. With this in mind, we report an intervention c

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Daley, Brianna, and Rob Kortum. "Abstract B007: Proximal RTK signaling regulates tumor initiating cell survival and therapeutic responsiveness in EGFR- and KRAS-mutated lung adenocarcinoma." Molecular Cancer Research 21, no. 5_Supplement (2023): B007. http://dx.doi.org/10.1158/1557-3125.ras23-b007.

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Abstract Lung cancer is the leading cause of cancer-related death worldwide; adenocarcinoma is the most common subtype of lung cancer. Oncogenic driver mutations in the RTK/RAS pathway occur in 75-90% of LUAD. Oncogene-targeted therapies substantially improve outcomes in LUAD; however, recalcitrant tumors invariably emerge necessitating novel therapeutic approaches that either delay therapeutic resistance or treat resistant cancers to enhance patient outcomes. Resistance to oncogene-targeted therapies in LUAD is commonly due to RTK pathway reactivation. Resistance to osimertinib in EGFR-mutate

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21

Krasova, Elena V. "The information technology and communication stressors impact on workers’ health." Russian Journal of Occupational Health and Industrial Ecology 62, no. 9 (2022): 616–26. http://dx.doi.org/10.31089/1026-9428-2022-62-9-616-626.

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The information, computer and communication technologies (ICT) impact on workers’ health is one of the actual interdisciplinary issues of modern science and practice. Numerous studies and observations have revealed negative impact of ICT on workers’ health. Just in Russia today about 40-45 million people employed in various fields of activity are at the ICT-risk group. The ICT negative impact on human body is manifested through the information technology and communication stressors (TICS). However, this impact’s mechanism requires to be clearer, and scientific results that have been already ob

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Zinna, S., and M. Kyriakopoulos. "Clinical correlates of comorbid chronic tics and Tourette syndrome in a National Inpatient Children's Unit." European Psychiatry 33, S1 (2016): S137. http://dx.doi.org/10.1016/j.eurpsy.2016.01.220.

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IntroductionChronic tics and Tourette syndrome (TS) can be comorbid with several neuropsychiatric conditions and may add to the complexity of children's clinical presentation and need for inpatient input.ObjectivesTo review the clinical notes of all children admitted to a National Children's Inpatient Unit (aged up to 12 years) over a 5-year period and analyse their demographic and clinical characteristics including the presence of chronic tics/TS.AimsTo assess the clinical correlates of comorbid chronic tics/TS in an inpatient preadolescent population.MethodsA retrospective naturalistic study

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Samonig, Lisa, Andrea Loipetzberger, Constantin Blöchl, et al. "Proteins and Molecular Pathways Relevant for the Malignant Properties of Tumor-Initiating Pancreatic Cancer Cells." Cells 9, no. 6 (2020): 1397. http://dx.doi.org/10.3390/cells9061397.

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Cancer stem cells (CSCs), a small subset of the tumor bulk with highly malignant properties, are deemed responsible for tumor initiation, growth, metastasis, and relapse. In order to reveal molecular markers and determinants of their tumor-initiating properties, we enriched rare stem-like pancreatic tumor-initiating cells (TICs) by harnessing their clonogenic growth capacity in three-dimensional multicellular spheroid cultures. We compared pancreatic TICs isolated from three-dimensional tumor spheroid cultures with nontumor-initiating cells (non-TICs) enriched in planar cultures. Employing dif

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Sfredo, Ericson, Felipe Martins de Lima Cecchini, Sérgio Fernando Raupp, Julia Bertholdo Bossardi, and Asdrubal Falavigna. "Motor tic disorder and traumatic cervical myelopathy: a case report." Coluna/Columna 10, no. 2 (2011): 152–54. http://dx.doi.org/10.1590/s1808-18512011000200015.

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The association between motor tics and cervical myelopathy is rare and not well understood. Only a few papers in the literature reported this disorder until the present date. This is a case report of a cervical myelopathy case secondary to a motor tic disorder. A 23-year-old male with a 10-year history of motor tic disorder, involving sudden forced extension of the head and cervical spine. Disturbed tactile sensation and kinetic posturing that progressed to the Lhermitte sign every time he made the movement were detected over the last six months. Magnetic resonance imaging (MRI) showed hyperin

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Khraim, Hamza. "The influence of technological innovative capabilities on firm performance: Moderating effect of strategic agility." Problems and Perspectives in Management 20, no. 2 (2022): 459–70. http://dx.doi.org/10.21511/ppm.20(2).2022.38.

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This study investigates the influence of technological innovative capabilities (TICs) on firm performance (FP) in the IT sector, with strategic agility as a moderator variable. This paper analyzes the TICs at the firm level in the service sector using the functional approach. An online structured questionnaire was adapted and refined to collect the required information on the influence of TICs dimensions on FP in the IT sector to achieve the objectives. The unit of analysis consists of top management staff and heads of departments from IT firms in Amman, Jordan. A sample of 67 IT firms was sel

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Ludlow, Amanda K., Seonaid Anderson, Sally Robinson, Tamsin Owen, and Tammy Hedderly. "An investigation into mothers’ experiences of their children’s functional tic-like behaviour and tic attacks." PLOS ONE 19, no. 1 (2024): e0292742. http://dx.doi.org/10.1371/journal.pone.0292742.

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Objective This is the first study to systematically explore the lived experiences of sudden and new onset of severe functional tics from the perspective of the mother’s experiences and describes their attempts to access support services in the United Kingdom. Method Twenty-One mothers of young people aged between 12 to 17 years with functional tic-like behaviour (FTLB) took part in semi-structured interviews. Thematic analysis of the transcribed interviews revealed gaps and inconsistencies within the process of gaining access to professional services and a lack of support for the management of

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Müller‐Vahl, Kirsten R., and Mark J. Edwards. "Mind the Difference Between Primary Tics and Functional Tic‐like Behaviors." Movement Disorders 36, no. 12 (2021): 2716–18. http://dx.doi.org/10.1002/mds.28853.

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Cavanna, Andrea Eugenio, Virginia Caimi, Elisa Capriolo, et al. "Neurodevelopmental Tics with Co-Morbid Functional Tic-like Behaviors: Diagnostic Challenges of a Complex Tourette Syndrome Phenotype." Brain Sciences 15, no. 5 (2025): 435. https://doi.org/10.3390/brainsci15050435.

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Background/Objectives: The co-morbidity between neurodevelopmental tics and functional tic-like behaviors (FTBs) in patients with Tourette syndrome (TS) is relatively under-investigated. The demographic and clinical characteristics of a large sample of patients with TS who presented with co-morbid FTBs (functional overlay) were assessed to raise awareness of this complex clinical presentation and to shed light on the differential diagnosis between the two conditions. Methods: We analyzed the clinical data of 63 patients (44 females, mean age 24 years, range 13–40) with pre-existing TS who (sub

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Gorberg, Victoria, Tamar Harpaz, Emilya Natali Shamir, et al. "A Tourette Syndrome/ADHD-like Phenotype Results from Postnatal Disruption of CB1 and CB2 Receptor Signalling." International Journal of Molecular Sciences 26, no. 13 (2025): 6052. https://doi.org/10.3390/ijms26136052.

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Cannabinoid receptor 1 (CB1) signalling is critical for weight gain and for milk intake in newborn pups. This is important as in humans, low birth weight increases the risk for attention-deficit hyperactivity disorder (ADHD). Moreover, some children with ADHD also have Tourette syndrome (TS). However, it remains unclear if insufficient CB1 receptor signalling may promote ADHD/TS-like behaviours. Here, ADHD/TS-like behaviours were studied from postnatal to adulthood by exposing postnatal wild-type CB1 and Cannabinoid receptor 2 (CB2) knockout mouse pups to SR141716A (rimonabant), a CB1 receptor

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N., Revathi, Jayakumar M., Ajidhabharathi S. D., and Abdul Rahim A. "Clinical correlates, characteristics and comorbidities of paediatric tic disorders." International Journal of Contemporary Pediatrics 10, no. 8 (2023): 1211–15. http://dx.doi.org/10.18203/2349-3291.ijcp20232236.

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Background: Tic disorders are complex neuropsychiatric disorders of childhood onset. The associated comorbidities in paediatric tic disorders are of vast importance as they account for the major functional impairment in these children, data of which is lacking in our Indian context. Methods: Descriptive Cross-sectional study conducted among children of 3-15 years of age in child psychiatry department of Institute of Child health, Egmore, Chennai Results: In this study 60 patients were studied of whom 47 were male and 13 were females. Comorbid psychiatric disorders were present in 38 (63.3%) ch

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Lamanna, Jacopo, Mattia Ferro, Sara Spadini, Gabriella Racchetti, and Antonio Malgaroli. "The Dysfunctional Mechanisms Throwing Tics: Structural and Functional Changes in Tourette Syndrome." Behavioral Sciences 13, no. 8 (2023): 668. http://dx.doi.org/10.3390/bs13080668.

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Tourette Syndrome (TS) is a high-incidence multifactorial neuropsychiatric disorder characterized by motor and vocal tics co-occurring with several diverse comorbidities, including obsessive-compulsive disorder and attention-deficit hyperactivity disorder. The origin of TS is multifactorial, with strong genetic, perinatal, and immunological influences. Although almost all neurotransmettitorial systems have been implicated in TS pathophysiology, a comprehensive neurophysiological model explaining the dynamics of expression and inhibition of tics is still lacking. The genesis and maintenance of

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Dufrene, Brad A., Lauren Lestremau Harpole, Heather E. Sterling, Erin J. Perry, Britney Burton, and Kimberly Zoder-Martell. "Functional Analysis Identified Habit Reversal Components for the Treatment of Motor Tics." Child & Family Behavior Therapy 35, no. 1 (2013): 41–62. http://dx.doi.org/10.1080/07317107.2013.761036.

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Cagle, Jackson N., Michael S. Okun, Enrico Opri, et al. "Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuit." Journal of Neurology, Neurosurgery & Psychiatry 91, no. 5 (2020): 533–39. http://dx.doi.org/10.1136/jnnp-2019-321973.

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ObjectivesTourette syndrome is a neurodevelopmental disorder commonly associated with involuntary movements, or tics. We currently lack an ideal animal model for Tourette syndrome. In humans, clinical manifestation of tics cannot be captured via functional imaging due to motion artefacts and limited temporal resolution, and electrophysiological studies have been limited to the intraoperative environment. The goal of this study was to identify electrophysiological signals in the centromedian (CM) thalamic nucleus and primary motor (M1) cortex that differentiate tics from voluntary movements.Met

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Maataoui, Z. El, B. Bensaleh, and H. Kisra. "Functional Neurological Symptom Disorder (FNSD)." Scholars Academic Journal of Biosciences 12, no. 09 (2024): 291–93. http://dx.doi.org/10.36347/sajb.2024.v12i09.002.

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Functional Neurological Symptom Disorder (FNSD) is characterized by neurological, sensory, or motor symptoms without identifiable neurological pathology. In children and adolescents, FNSD presents additional complexities due to frequent comorbidities such as anxiety, depression, and functional pain, complicating diagnosis and treatment. This study explores the clinical presentations, diagnostic challenges, and the organo-psychiatric interplay in FNSD through three pediatric cases. Case 1 involved a 12-year-old boy with epileptiform seizures, behavioral disinhibition, and cognitive deterioratio

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Hubbard, Molly E., Abdullah Bin Zahid, Gabrielle Meyer, et al. "306 GCS Does Not Predict Cognitive Outcome 30 Years After Severe Traumatic Brain Injury." Neurosurgery 64, CN_suppl_1 (2017): 264–65. http://dx.doi.org/10.1093/neuros/nyx417.306.

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Abstract INTRODUCTION Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in the US. The effects of TBI on quality of life may not become apparent for years after the injury. There are conflicting reports in the literature regarding long term outcomes. Physicians are often asked to predict long term functional and cognitive outcomes, with limited data available. METHODS Patients with severe TBI (GCS = 9) who previously participated in a clinical trial during the 1980s were followed up with and compared to healthy controls without history of TBI. A health questionnaire, s

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Berzosa-Gonzalez, Irene, Saul Martinez-Horta, Jesus Pérez-Pérez, Jaime Kulisevsky, and Javier Pagonabarraga. "Therapeutic Approach to Primary Tic Disorders and Associated Psychiatric Comorbidities." Brain Sciences 14, no. 12 (2024): 1231. https://doi.org/10.3390/brainsci14121231.

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Background/Objectives: The treatment of tics and psychiatric comorbidities is crucial when they affect the patient’s well-being and relationships. However, the optimal pharmacological treatment (PT) tailored to each patient’s phenotype remains unclear. The primary objective of this study is to describe the clinical characteristics and treatment received for tics and psychiatric comorbidities in our cohort of children and adult patients with tic disorders. Additionally, a further aim was to quantify the severity of tics, comorbidities and overall severity, and the overall clinical changes obser

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Williams, Victoria J., Cynthia M. Carlsson, Anne Fischer, et al. "Assessing Dementia Prevalence in the Wisconsin Longitudinal Study: Cohort Profile, Protocol, and Preliminary Findings." Journal of Alzheimer's Disease 81, no. 2 (2021): 751–68. http://dx.doi.org/10.3233/jad-201422.

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Background: There is growing consensus that non-genetic determinants of dementia can be linked to various risk- and resiliency-enhancing factors accumulating throughout the lifespan, including socioeconomic conditions, early life experiences, educational attainment, lifestyle behaviors, and physical/mental health. Yet, the causal impact of these diverse factors on dementia risk remain poorly understood due to few longitudinal studies prospectively characterizing these influences across the lifespan. Objective: The Initial Lifespan’s Impact on Alzheimer’s Disease and Related Dementia (ILIAD) st

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Singer, Harvey S., and Farhan Augustine. "The Pathophysiology of Tics; An Evolving Story." Current Drug Therapy 15, no. 2 (2020): 92–123. http://dx.doi.org/10.2174/1574885514666191121143930.

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Background: Tics, defined as quick, rapid, sudden, recurrent, non-rhythmic motor movements or vocalizations are required components of Tourette Syndrome (TS) - a complex disorder characterized by the presence of fluctuating, chronic motor and vocal tics, and the presence of co-existing neuropsychological problems. Despite many advances, the underlying pathophysiology of tics/TS remains unknown. Objective: To address a variety of controversies surrounding the pathophysiology of TS. More specifically: 1) the configuration of circuits likely involved; 2) the role of inhibitory influences on motor

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Rajan, Prithi, and Roopa Srinivasan. "Immunotherapies Towards Tumor Initiating Cells and Cancer Stem Cells." Open Cancer Immunology Journal 1, no. 1 (2008): 1–6. http://dx.doi.org/10.2174/1876401000801010001.

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Active immunotherapy of cancer is a promising treatment modality by inducing long lived tumor reactive immune effector cells. Several vaccine trials have indicated that its effectiveness is probably best when the tumor burden is low. An attractive population of cells to target by this approach may be tumor initiating cells (TICs). Recent research suggests that such types of cells may be precursors to cancer possibly giving rise to metastatic disease. Although more work is being done to characterize appropriate phenotypic and functional markers, this population of cells would make an ideal targ

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Saez-Clarke, Estefany, Molly Ream, Paula Popok, et al. "8 Self-Reported versus Performance-Based Cancer-Related Cognitive Impairment in Older Women with Nonmetastatic Breast Cancer." Journal of the International Neuropsychological Society 29, s1 (2023): 10–11. http://dx.doi.org/10.1017/s1355617723000917.

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Objective:The Functional Assessment of Cancer Therapy-Cognitive scale (FACT-Cog) is one of the most frequently used patient-reported outcome (PRO) measures of cancer-related cognitive impairment (CRCI) and of CRCI-related impact on quality of life (QOL). Previous studies using the FACT-Cog found that >75% of women with breast cancer (BCa) experience CRCI. Distress tolerance (DT) is a complex construct that encompasses both the perceived capacity (i.e., cognitive appraisal) and the behavioral act of withstanding uncomfortable/aversive/negative emotional or physical experiences. Low DT is ass

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Bhikram, Tracy, Paul Arnold, Adrian Crawley, Elia Abi-Jaoude, and Paul Sandor. "The functional connectivity profile of tics and obsessive-compulsive symptoms in Tourette Syndrome." Journal of Psychiatric Research 123 (April 2020): 128–35. http://dx.doi.org/10.1016/j.jpsychires.2020.01.019.

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Laguë, A., M. Émond, V. Boucher, et al. "P072: Using the Bergman-Paris Question to detect ED seniors’ cognitive impairment and functional status." CJEM 18, S1 (2016): S102. http://dx.doi.org/10.1017/cem.2016.248.

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Introduction: Mild Cognitive Impairment (MCI) remains frequently undiagnosed and Emergency Department (ED) guidelines suggest screening for CI. The Bergman-Paris Question (BPQ) which is currently used in memory clinics, is a one-question screening test administered to the patient’s relative; a negative answer suggests presence of CI. We sought to validate if the BPQ would be associated with MCI and functional status in ED elders. Methods: A planned sub-study of the prospective MIDI-INDEED study on ED-induced delirium, which included patients from 4 Canadian EDs was realized. Inclusion criteria

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Tulen, J. H. M., B. J. M. van de Wetering, and F. Boomsma. "Autonomic Regulation during Rest and Mental Load in Gilles de la Tourette Syndrome." Psychological Reports 83, no. 2 (1998): 515–29. http://dx.doi.org/10.2466/pr0.1998.83.2.515.

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Cardiovascular and catecholaminergic activity during mental load were studied in patients with Tourette syndrome. Patients and controls performed the Color Word Test, preceded by a baseline period, with continuous measurements of heart rate and blood pressure. Blood samples for assay of plasma catecholamine concentrations were obtained before and during the test. The patients showed higher heart rate and blood pressure during baseline than controls, but no differences regarding plasma catecholamines. The tics corresponded with transient increases in heart rate and blood pressure. Spectral anal

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Hussain, Humaira. "PRESENCE OF DYSPHONIA IN INDIVIDUALS WITH TOURETTE’S SYNDROME." Pakistan Journal of Rehabilitation 4, no. 1 (2015): 42–47. http://dx.doi.org/10.36283/pjr.zu.4.1/009.

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Professionals working in the field of voice disorders have come to recognize the variability of vocal qualities in different populations. While voice disorders can be of organic, neurogenic, or functional etiology, concomitant disorders often directly impact the vocal features. Such a disorder is Tourette’s Syndrome which is an impairment characterized by motor and vocal tics. This study examined the prevalence of voice disorders in individuals with Tourette’s Syndrome. Research was conducted over the duration of two years with clientele aged 15;2 to 26;5. Participants were receiving continuou

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Szejko, Natalia, Sally Robinson, Andreas Hartmann, et al. "European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part I: assessment." European Child & Adolescent Psychiatry 31, no. 3 (2021): 383–402. http://dx.doi.org/10.1007/s00787-021-01842-2.

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AbstractIn 2011 a working group of the European Society for the Study of Tourette Syndrome (ESSTS) has developed the first European assessment guidelines for Tourette syndrome (TS). Now, we present an updated version 2.0 of these European clinical guidelines for Tourette syndrome and other tic disorders, part I: assessment. Therefore, the available literature has been thoroughly screened, supplemented with national guidelines across countries and discussions among ESSTS experts. Diagnostic changes between DSM-IV and DSM-5 classifications were taken into account and new information has been add

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Morariu, David. "Functional Interdiscursivity and Linguistic Conventions in Neuronovels." Linguaculture 14, no. 2 (2023): 32–56. http://dx.doi.org/10.47743/lincu-2023-2-0342.

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This study aims to challenge, both theoretically and practically, the concept of genre in translation studies. First, starting from the conceptual delimitation and theoretical boundaries between text type, genre and register, this article presents the characteristics of these concepts and their applicability in relation to the translation process. Secondly, by exploiting the functionality of interdiscursivity and hybridisation of genres, the present analysis proposes a discussion of how the neuronovel fluidises the boundaries between literary genre and neuroscientific discourse through the “ne

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Eichele, Heike, and Kerstin J. Plessen. "Neural Plasticity in Functional and Anatomical MRI Studies of Children with Tourette Syndrome." Behavioural Neurology 27, no. 1 (2013): 33–45. http://dx.doi.org/10.1155/2013/376590.

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Background:Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics. The typical clinical course of an attenuation of symptoms during adolescence in parallel with the emerging self-regulatory control during development suggests that plastic processes may play an important role in the development of tic symptoms.Methods:We conducted a systematic search to identify existing imaging studies (both anatomical and functional magnetic resonance imaging [fMRI]) in young persons under the age of 19 years with TS.Results:The final search re

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Čomić, Maša, Dragana Ratković, Vladimir Knežević, et al. "Attention deficit hyperactivity disorder (ADHD) associated with tics: Case report." Timocki medicinski glasnik 48, no. 4 (2023): 92–95. http://dx.doi.org/10.5937/tmg2304092c.

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Attention deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder in children and adolescents, with estimated global prevalence ranging between 5% and 12%. The frequency of ADHD comorbid with tics is significantly higher than expected. Children diagnosed with ADHD are much more likely to have chronic tics compared to those without ADHD. When ADHD occurs alongside tic disorders, treatment can be challenging. Through this case report, we aim to shed light on the unique challenges and potential treatment strategies for this comorbidity. A nine-year-old boy was admi

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Alharrasi, Azza, and Diane Berish. "ASSOCIATION OF COGNITIVE LEVEL AND QUALITY OF LIFE INDICATORS POSTSTROKE IN OLDER ADULTS: A CROSS-SECTIONAL STUDY." Innovation in Aging 8, Supplement_1 (2024): 941–42. https://doi.org/10.1093/geroni/igae098.3036.

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Abstract Stroke is one of the leading causes of death and disability worldwide. Post-stroke cognitive impairment (PSCI) is a common complication of stroke; however, mild cognitive impairment is highly prevalent within three months post-stroke and is associated with increased cost of care, hospitalizations, and care dependency. This study examined the association between cognition level (TICS total score) and quality of life indicators (Depression yes=1 no=0, physical limitations yes=1 no=0, socialization yes=1 no=0) among adults aged 65+. Therefore, a cross-sectional study using the 2020 wave

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Marotta, G., B. Costanza, D. Osti, et al. "P02.26.B METABOLIC PLASTICITY IN GLIOBLASTOMA TUMOR-INITIATING CELL AND RESISTANCE TO LSD1-DIRECTED THERAPY." Neuro-Oncology 25, Supplement_2 (2023): ii36. http://dx.doi.org/10.1093/neuonc/noad137.111.

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Abstract BACKGROUND Glioblastoma (GBM), the most common primary brain tumor in adults, remains incurable despite multimodal therapy. There is a pressing unmet medical need for new therapeutic strategies, especially because patients experience only short-term benefit after primary treatment and the vast majority inevitably relapse. Adaptation to harsh microenvironmental conditions, including nutrient deprivation, proteostasis perturbation, hypoxia and drug treatment, induce molecular and metabolic changes in glioblastoma that lead to the acquisition of a tolerance to stress and resistance to dr

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