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Journal articles on the topic 'Functionalized oligonucleotides'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Pérez-Rentero, Sónia, Alvaro Somoza, Santiago Grijalvo, et al. "Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/650610.

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Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized wi

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2

Kosiova, Ivana, and Pavol Kois. "Synthesis of Novel Coumarin-Based Fluorescent Probes." Collection of Czechoslovak Chemical Communications 72, no. 8 (2007): 996–1004. http://dx.doi.org/10.1135/cccc20070996.

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We report on synthesis of new fluorescent probes suitable for site-specific incorporation into oligonucleotides. Coumarin derivatives were used as sensitive fluorescent labels and were attached to glycerol unit by two types of linkers as potential building blocks for oligonucleotide synthesis. Spectral characteristics of the functionalized coumarin building blocks were measured.

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3

Parelius Jonášová, Eleonóra, and Bjørn Torger Stokke. "Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels." Polymers 12, no. 2 (2020): 268. http://dx.doi.org/10.3390/polym12020268.

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Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility and numerous applications. The possibility to use nucleic acid analogues opens for further customization of the hydrogels. In the present work, the commonly employed DNA oligonucleotides in DNA-co-acrylamide responsive hydrogels are replaced by Morpholino oligonucleotides. The uncharged backbone of this nucleic acid analogue makes it less susceptible to possible enzymatic degradation. In this work we address fundamental issues related to key processes in the hydrogel res

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4

SHARMA, GAURAV, ZHI-GANG SHE, DAVID T. VALENTA, WILLIAM B. STALLCUP, and JEFFREY W. SMITH. "SCAVENGER RECEPTOR-MEDIATED TARGETING OF MACROPHAGE FOAM CELLS IN ATHEROSCLEROTIC PLAQUE USING OLIGONUCLEOTIDE-FUNCTIONALIZED NANOPARTICLES." Nano LIFE 01, no. 03n04 (2010): 207–14. http://dx.doi.org/10.1142/s1793984410000183.

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Macrophage foam cells are key components of atherosclerotic plaque and play an important role in the progression of atherosclerosis leading to plaque rupture and thrombosis. Foam cells are emerging as attractive targets for therapeutic intervention and imaging the progression of disease. Therefore, designing nanoparticles (NPs) targeted to macrophage foam cells in plaque is of considerable therapeutic significance. Here we report the construction of an oligonucleotide-functionalized NP system with high affinity for foam cells. Nanoparticles functionalized with a 23-mer poly-Guanine (polyG) oli

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5

M. Varizhuk, Anna, Svetlana V. Kochetkova, Alexander U. Fedotov, Natalia A. Kolganova, Edward N. Timofeev, and Vladimir L. Florentiev. "Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages." Letters in Organic Chemistry 9, no. 2 (2012): 106–13. http://dx.doi.org/10.2174/157017812800221799.

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6

D'Agata, Roberta, Pasquale Palladino, and Giuseppe Spoto. "Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation." Beilstein Journal of Nanotechnology 8 (January 2, 2017): 1–11. http://dx.doi.org/10.3762/bjnano.8.1.

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Gold nanoparticles (AuNPs) exhibit unique properties that can be modulated through a tailored surface functionalization, enabling their targeted use in biochemical sensing and medical diagnostics. In particular, streptavidin-modified AuNPs are increasingly used for biosensing purposes. We report here a study of AuNPs surface-functionalized with streptavidin-biotinylated oligonucleotide, focussing on the role played by the oligonucleotide probes in the stabilization/destabilization of the functionalized nanoparticle dispersion. The behaviour of the modified AuNP dispersion as a consequence of t

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7

Kaura, Mamta, and Patrick J. Hrdlicka. "Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers." Organic & Biomolecular Chemistry 13, no. 26 (2015): 7236–47. http://dx.doi.org/10.1039/c5ob00860c.

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Mixmer oligonucleotides modified with LNA and C5-pyrene-functionalized DNA monomers are shown to display interesting fluorescence properties for the discrimination of single nucleotide polymorphisms (SNPs).

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8

Alexaki, Konstantina, Davide Giust, Maria-Eleni Kyriazi, et al. "A DNA sensor based on upconversion nanoparticles and two-dimensional dichalcogenide materials." Frontiers of Chemical Science and Engineering 15, no. 4 (2021): 935–43. http://dx.doi.org/10.1007/s11705-020-2023-9.

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AbstractWe demonstrate the fabrication of a new DNA sensor that is based on the optical interactions occurring between oligonucleotide-coated NaYF4:Yb3+;Er3+ upconversion nanoparticles and the two-dimensional dichalcogenide materials, MoS2 and WS2. Monodisperse upconversion nanoparticles were functionalized with single-stranded DNA endowing the nanoparticles with the ability to interact with the surface of the two-dimensional materials via van der Waals interactions leading to subsequent quenching of the upconversion fluorescence. By contrast, in the presence of a complementary oligonucleotide

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9

Huggins, Ian J., Carlos A. Medina, Aaron D. Springer, et al. "Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase." Molecules 24, no. 18 (2019): 3287. http://dx.doi.org/10.3390/molecules24183287.

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Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tris-GalNAc to siRNAs and ASOs has shown clinical efficacy in targeting diseases driven by liver hepatocytes. However, targeting non-hepatic diseases with oligonucleotide therapeutics has remained problematic for several reasons, including targeting specific cell types and endosomal escape. Monoclonal

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10

Wang, Chungang, Zhanfang Ma, and Zhongmin Su. "Facile method to detect oligonucleotides with functionalized polydiacetylene vesicles." Sensors and Actuators B: Chemical 113, no. 1 (2006): 510–15. http://dx.doi.org/10.1016/j.snb.2005.03.106.

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11

Murdock, Richard C., Omar A. Khan, Thomas J. Lamkin, Saber M. Hussain, and Nancy Kelley-Loughnane. "Hybridization State Detection of DNA-Functionalized Gold Nanoparticles Using Hyperspectral Imaging." International Journal of Optics 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8427459.

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Hyperspectral imaging has the unique ability of capturing spectral data for multiple wavelengths at each pixel in an image. This gives the ability to distinguish, with certainty, different nanomaterials and/or distinguish nanomaterials from biological materials. In this study, 4 nm and 13 nm gold nanoparticles (Au NPs) were synthesized, functionalized with complimentary oligonucleotides, and hybridized to form large networks of NPs. Scattering spectra were collected from each sample (unfunctionalized, functionalized, and hybridized) and evaluated. The spectra showed unique peaks for each size

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12

Wang, Yitong, Miaomiao Yan, Lu Xu, et al. "Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems." Journal of Materials Chemistry B 4, no. 32 (2016): 5446–54. http://dx.doi.org/10.1039/c6tb01224h.

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13

Guenther, Dale C., Pawan Kumar, Brooke A. Anderson, and Patrick J. Hrdlicka. "C5-Amino acid functionalized LNA: positively poised for antisense applications." Chem. Commun. 50, no. 64 (2014): 9007–9. http://dx.doi.org/10.1039/c4cc03623a.

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Oligonucleotides modified with C5-amino acid LNA uridine result in highly thermostable duplexes, with excellent discrimination of single nucleotide mismatches. Additionally, these ONs are inert toward 3′-exonuclease degradation.

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14

Hovinen, Jari, Andrei Guzaev, Alex Azhayev, and Harri Lönnberg. "Synthesis of 3′-functionalized oligonucleotides on a single solid support." Tetrahedron Letters 34, no. 50 (1993): 8169–72. http://dx.doi.org/10.1016/s0040-4039(00)61482-x.

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15

Li, Yuqing, Zijie Zhang, Biwu Liu, and Juewen Liu. "Adsorption of DNA Oligonucleotides by Boronic Acid-Functionalized Hydrogel Nanoparticles." Langmuir 35, no. 42 (2019): 13727–34. http://dx.doi.org/10.1021/acs.langmuir.9b01622.

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16

Shi, Yin-Feng, Zhong Tian, Yang Zhang, He-Bai Shen, and Neng-Qin Jia. "Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides." Nanoscale Research Letters 6, no. 1 (2011): 608. http://dx.doi.org/10.1186/1556-276x-6-608.

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17

Okamoto, Akimitsu, Kazuhito Tanabe, Takeshi Inasaki, and Isao Saito. "Phototriggered Drug Release from Functionalized Oligonucleotides by a Molecular Beacon Strategy." Angewandte Chemie International Edition 42, no. 22 (2003): 2502–4. http://dx.doi.org/10.1002/anie.200250832.

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18

Polushin, N. "THE MOX/SUC PRECURSOR STRATEGIES: ROBUST WAYS TO CONSTRUCT FUNCTIONALIZED OLIGONUCLEOTIDES." Nucleosides, Nucleotides and Nucleic Acids 20, no. 4-7 (2001): 973–76. http://dx.doi.org/10.1081/ncn-100002471.

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19

Kim, Jae-Hong, Ji-Hyun Yeom, Jeong-Jae Ko, et al. "Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles." Journal of Biotechnology 155, no. 3 (2011): 287–92. http://dx.doi.org/10.1016/j.jbiotec.2011.07.014.

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20

Gheerardijn, Vicky, Jos Van den Begin, and Annemieke Madder. "Versatile synthesis of amino acid functionalized nucleosides via a domino carboxamidation reaction." Beilstein Journal of Organic Chemistry 10 (November 4, 2014): 2566–72. http://dx.doi.org/10.3762/bjoc.10.268.

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Functionalized oligonucleotides have recently gained increased attention for incorporation in modified nucleic acid structures both for the design of aptamers with enhanced binding properties as well as the construction of catalytic DNA and RNA. As a shortcut alternative to the incorporation of multiple modified residues, each bearing one extra functional group, we present here a straightforward method for direct linking of functionalized amino acids to the nucleoside base, thus equipping the nucleoside with two extra functionalities at once. As a proof of principle, we have introduced three a

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21

Reynolds, Robert A., Chad A. Mirkin, and Robert L. Letsinger. "A gold nanoparticle/latex microsphere-based colorimetric oligonucleotide detection method." Pure and Applied Chemistry 72, no. 1-2 (2000): 229–35. http://dx.doi.org/10.1351/pac200072010229.

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An exceptionally simple and effective DNA detection methodology based on latex microsphere and gold nanoparticle probes has been developed. The latex and gold particle probes, which were functionalized with separate oligonucleotide sequences, undergo hybridization in the presence of target strands that are complementary to both of the probes. Duplex formation thus results in linking of gold nanoparticles to the latex microspheres and a corresponding white-to-red color change, which, because of the particularly large extinction coefficient of the gold nanoparticles, is clearly visible to the na

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22

HOVINEN, J., A. GUZAEV, A. AZHAYEV, and H. LOENNBERG. "ChemInform Abstract: Synthesis of 3′-Functionalized Oligonucleotides on a Single Solid Support." ChemInform 25, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199413248.

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23

Rublack, Nico, Hien Nguyen, Bettina Appel, Danilo Springstubbe, Denise Strohbach, and Sabine Müller. "Synthesis of Specifically Modified Oligonucleotides for Application in Structural and Functional Analysis of RNA." Journal of Nucleic Acids 2011 (2011): 1–19. http://dx.doi.org/10.4061/2011/805253.

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Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying site-specific modifications for structure and function studies are needed. This often requires labeling of the RNA with a suitable spectroscopic reporter group. Herein, we describe the synthesis of functionalized monomer building blocks that upon incorporation in RNA allow for selective reaction with a specific

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24

Corrêa, Ricardo, Filipe da Cruz, Cátia Santos, Thiago Pimenta, Diego Franco, and Lucas Ferreira. "Optimization and Application of Electrochemical Transducer for Detection of Specific Oligonucleotide Sequence for Mycobacterium tuberculosis." Biosensors 8, no. 3 (2018): 84. http://dx.doi.org/10.3390/bios8030084.

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In this study, the electropolymerization of 4-hydroxyphenylacetic acid (4-HPA) over graphite electrodes (GE) was optimized, aiming its application as a functionalized electrochemical platform for oligonucleotides immobilization. It was investigated for the number of potential cycles and the scan rate influence on the monomer electropolymerization by using cyclic voltammetry technique. It was observed that the polymeric film showed a redox response in the region of +0.53/+0.38 V and the increase in the number of cycles produces more electroactive platforms because of the better electrode covera

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25

Žuržul, Nataša, and Bjørn Torger Stokke. "DNA Aptamer Functionalized Hydrogels for Interferometric Fiber-Optic Based Continuous Monitoring of Potassium Ions." Biosensors 11, no. 8 (2021): 266. http://dx.doi.org/10.3390/bios11080266.

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In the present paper, we describe a potassium sensor based on DNA-aptamer functionalized hydrogel, that is capable of continuous label-free potassium ion (K+) monitoring with potential for in situ application. A hydrogel attached to the end of an optical fiber is designed with di-oligonucleotides grafted to the polymer network that may serve as network junctions in addition to the covalent crosslinks. Specific affinity toward K+ is based on exploiting a particular aptamer that exhibits conformational transition from single-stranded DNA to G-quadruplex formed by the di-oligonucleotide in the pr

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26

Dubey, I. Ya, L. V. Dubey, and D. M. Fedoryak. "Synthesis of 3'- and 3',5'-modified oligonucleotides on functionalized silica Silochrom-2." Biopolymers and Cell 23, no. 2 (2007): 137–42. http://dx.doi.org/10.7124/bc.000760.

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27

Salo, Harri, Pasi Virta, Harri Hakala, et al. "Aminooxy Functionalized Oligonucleotides: Preparation, On-Support Derivatization, and Postsynthetic Attachment to Polymer Support." Bioconjugate Chemistry 10, no. 5 (1999): 815–23. http://dx.doi.org/10.1021/bc990021m.

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28

Zhang, H., Z. Li, and C. A. Mirkin. "Dip-Pen Nanolithography-Based Methodology for Preparing Arrays of Nanostructures Functionalized with Oligonucleotides." Advanced Materials 14, no. 20 (2002): 1472–74. http://dx.doi.org/10.1002/1521-4095(20021016)14:20<1472::aid-adma1472>3.0.co;2-e.

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29

Turri, Stefano, Luca Torlaj, and Marinella Levi. "Towards Nanowriting on Plastics: Dip-Pen Nanolithography of Acrylamido-Functionalized Oligonucleotides on Polystyrene." Macromolecular Rapid Communications 31, no. 15 (2010): 1373–77. http://dx.doi.org/10.1002/marc.201000107.

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30

Sirsi, Shashank R., Rebecca C. Schray, Xiangying Guan, et al. "Functionalized PEG–PEI Copolymers Complexed to Exon-Skipping Oligonucleotides Improve Dystrophin Expression inmdxMice." Human Gene Therapy 19, no. 8 (2008): 795–806. http://dx.doi.org/10.1089/hum.2007.129.

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31

Байрамов, Ф. Б., Е. Д. Полоскин, A. Л. Чернев та ін. "Время жизни колебательных состояний молекул ДНК в функционализированных комплексах полупроводниковых квантовых точек". Письма в журнал технической физики 44, № 2 (2018): 72. http://dx.doi.org/10.21883/pjtf.2018.02.45467.17050.

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AbstractResults of studying nanocrystalline nc-Si/SiO_2 quantum dots (QDs) functionalized by short oligonucleotides show that complexes of isolated crystalline semiconductor QDs are unique objects for detecting the manifestation of new quantum confinement phenomena. It is established that narrow lines observed in high-resolution spectra of inelastic light scattering can be used for determining the characteristic time scale of vibrational excitations of separate nucleotide molecules and for studying structural-dynamic properties of fast oscillatory processes in biomacromolecules.

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32

Moshari, Mahsa, Dipak Koirala, and Peter B. Allen. "Facile Fabrication of DNA Biosensors Based on Oxidized Carbon Black and Graphite Oxide." Proceedings 41, no. 1 (2019): 70. http://dx.doi.org/10.3390/ecsoc-23-06612.

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We investigated electrochemical sensors based on graphite oxide (GrO) and oxidized carbon black (CbO). GrO and CbO were synthesized by the modified Hummers method. Single-stranded DNA (ssDNA) probes were synthesized with a 5′ primary amine for attachment. These ssDNA oligonucleotides were immobilized on GrO and CbO using standard 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) coupling. This formed an amide bond between the DNA-amine and carboxyl groups on GrO and CbO. GrO and CbO were used instead of graphite in a carbon paste material. This significantly enhanced the sensitivity of the

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33

Gossai, Nathan, Jordan Naumann, Ed Zamora, Nan-Sheng Li, Joseph Piccirilli, and Peter M. Gordon. "Drug-DNA Conjugated Gold Nanoparticles for the Treatment of Acute Myeloid Leukemia." Blood 126, no. 23 (2015): 4935. http://dx.doi.org/10.1182/blood.v126.23.4935.4935.

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Abstract INTRODUCTION: Novel therapies are needed for acute myeloid leukemia as only ~60% of children are cured despite maximally intensive cytotoxic chemotherapy. Functionalized gold nanoparticles (AuNP) are utilized for many biomedical applications and represent a potentially novel therapeutic approach in leukemia. We enhanced this technology by developing an AuNP system that selectively releases molecularly targeted drugs in leukemia cells. METHODS: AuNPs were functionalized with short, double-stranded oligonucleotides with sequence complementarity to genes overexpressed in or unique to a l

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34

Navarro, Aude-Emmanuelle, Frédéric Fages, Corinne Moustrou, et al. "Characterization of PEDOT film functionalized with a series of automated synthesis ferrocenyl-containing oligonucleotides." Tetrahedron 61, no. 16 (2005): 3947–52. http://dx.doi.org/10.1016/j.tet.2005.02.058.

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35

McGettrick, James D., Wayne C. E. Schofield, Richard P. Garrod, and Jas Pal S. Badyal. "A Substrate-Independent Approach for the Surface Immobilization of Oligonucleotides using Aldehyde Functionalized Surfaces." Chemical Vapor Deposition 15, no. 4-6 (2009): 122–27. http://dx.doi.org/10.1002/cvde.200806739.

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36

Jassoy, J. Jacques, Caspar A. Heubach, Tobias Hett, et al. "Site Selective and Efficient Spin Labeling of Proteins with a Maleimide-Functionalized Trityl Radical for Pulsed Dipolar EPR Spectroscopy." Molecules 24, no. 15 (2019): 2735. http://dx.doi.org/10.3390/molecules24152735.

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Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS) in combination with site-directed spin labeling (SDSL) of proteins and oligonucleotides is a powerful tool in structural biology. Instead of using the commonly employed gem-dimethyl-nitroxide labels, triarylmethyl (trityl) spin labels enable such studies at room temperature, within the cells and with single-frequency electron paramagnetic resonance (EPR) experiments. However, it has been repeatedly reported that labeling of proteins with trityl radicals led to low labeling efficiencies, unspecific labeling and label aggregation.

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37

Marchant, María José, Leda Guzmán, Alejandro H. Corvalán, and Marcelo J. Kogan. "Gold@Silica Nanoparticles Functionalized with Oligonucleotides: A Prominent Tool for the Detection of the Methylated Reprimo Gene in Gastric Cancer by Dynamic Light Scattering." Nanomaterials 9, no. 9 (2019): 1333. http://dx.doi.org/10.3390/nano9091333.

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Reprimo (RPRM) is a tumor suppressor gene involved in the development of gastric cancer. Hypermethylation of the RPRM promoter region has been found in tumor tissue and plasma samples from patients with gastric cancer. These findings suggest that circulating methylated DNA of RPRM could be a candidate for a noninvasive detection of gastric cancer. We designed a nanosystem based on the functionalization of silica coated gold nanoparticles with oligonucleotides that recognize a specific DNA fragment of the RPRM promoter region. The functionality of the oligonucleotide on the surface of the nanop

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38

Kumar, Rajesh, Annika Ries, and Jesper Wengel. "Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2′-Amino-LNA Functionalized with Galactose Units." Molecules 22, no. 5 (2017): 852. http://dx.doi.org/10.3390/molecules22050852.

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39

Østergaard, Michael E., and Patrick J. Hrdlicka. "Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology." Chemical Society Reviews 40, no. 12 (2011): 5771. http://dx.doi.org/10.1039/c1cs15014f.

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40

Cech, D., K. Ahlert, U. Möller, and F. Schubert. "Non-radioactive labelling of oligonucleotides with pre-functionalized phosphoramidites or H-phosphonates during automated synthesis." Collection of Czechoslovak Chemical Communications 55, s1 (1990): 221–24. http://dx.doi.org/10.1135/cccc1990s221.

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41

Liu, Kai, Lifei Zheng, Qing Liu, Jan Willem de Vries, Jennifer Y. Gerasimov, and Andreas Herrmann. "Nucleic Acid Chemistry in the Organic Phase: From Functionalized Oligonucleotides to DNA Side Chain Polymers." Journal of the American Chemical Society 136, no. 40 (2014): 14255–62. http://dx.doi.org/10.1021/ja5080486.

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42

Xia, Qingming, Chunai Gong, Fenfen Gu, et al. "Functionalized Multi-Walled Carbon Nanotubes for Targeting Delivery of Immunostimulatory CpG Oligonucleotides Against Prostate Cancer." Journal of Biomedical Nanotechnology 14, no. 9 (2018): 1613–26. http://dx.doi.org/10.1166/jbn.2018.2605.

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43

Kaura, Mamta, Dale C. Guenther, and Patrick J. Hrdlicka. "Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability." Organic Letters 16, no. 12 (2014): 3308–11. http://dx.doi.org/10.1021/ol501306u.

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44

Chen, Yang, Jenny Aveyard, and Robert Wilson. "Gold and silver nanoparticles functionalized with known numbers of oligonucleotides per particle for DNA detection." Chemical Communications, no. 24 (2004): 2804. http://dx.doi.org/10.1039/b411181h.

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45

Tao, Yu, Yan Zhang, Enguo Ju, Jinsong Ren, and Xiaogang Qu. "One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging." Colloids and Surfaces B: Biointerfaces 126 (February 2015): 585–89. http://dx.doi.org/10.1016/j.colsurfb.2014.12.037.

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46

Pla, Luis, Beatriz Lozano-Torres, Ramón Martínez-Máñez, Félix Sancenón, and Jose V. Ros-Lis. "Overview of the Evolution of Silica-Based Chromo-Fluorogenic Nanosensors." Sensors 19, no. 23 (2019): 5138. http://dx.doi.org/10.3390/s19235138.

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This review includes examples of silica-based, chromo-fluorogenic nanosensors with the aim of illustrating the evolution of the discipline in recent decades through relevant research developed in our group. Examples have been grouped according to the sensing strategies. A clear evolution from simply functionalized materials to new protocols involving molecular gates and the use of highly selective biomolecules such as antibodies and oligonucleotides is reported. Some final examples related to the evolution of chromogenic arrays and the possible use of nanoparticles to communicate with other na

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47

Emehiser, Raymond G., та Patrick J. Hrdlicka. "Chimeric γPNA–Invader probes: using intercalator-functionalized oligonucleotides to enhance the DNA-targeting properties of γPNA". Organic & Biomolecular Chemistry 18, № 7 (2020): 1359–68. http://dx.doi.org/10.1039/c9ob02726b.

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Chimeric γPNA–Invader probes are energetically activated to recognize complementary double-stranded (ds) DNA targets and engineered to reduce γPNA dimerization and improve the specificity of the recognition process vis-à-vis single-stranded γPNAs.

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48

Kupryushkin, M. S., and D. V. Pyshnyi. "A convenient method for the synthesis of phosphoramidite non-nucleotide inserts for preparation of functionalized oligonucleotides." Russian Journal of Bioorganic Chemistry 38, no. 6 (2012): 662–66. http://dx.doi.org/10.1134/s1068162012060106.

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49

Frommer, Jennifer, and Sabine Müller. "Changed reactivity of secondary hydroxy groups in C8-modified adenosine – lessons learned from silylation." Beilstein Journal of Organic Chemistry 16 (November 23, 2020): 2854–61. http://dx.doi.org/10.3762/bjoc.16.234.

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Synthesis of site-specifically modified oligonucleotides has become a major tool for RNA structure and function studies. Reporter groups or specific functional entities are required to be attached at a pre-defined site of the oligomer. An attractive strategy is the incorporation of suitably functionalized building blocks that allow post-synthetic conjugation of the desired moiety. A C8-alkynyl-modified adenosine derivative was synthesized, reviving an old synthetic pathway for iodination of purine nucleobases. Silylation of the C8-alkynyl-modified adenosine revealed unexpected selectivity of t

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Pierik, Anke, J. Frits Dijksman, Johan Lub, Henk R. Stapert, and Dirk J. Broer. "Immobilization of Oligonucleotides with Homo-oligomer Tails onto Amine-Functionalized Solid Substrates and the Effects on Hybridization." Analytical Chemistry 82, no. 4 (2010): 1191–99. http://dx.doi.org/10.1021/ac902561w.

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