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Journal articles on the topic 'Functionnal genes'

Author: Grafiati

Published: 11 January 2025

Last updated: 31 July 2025

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1

Sitnicka, Dorota, Katarzyna Figurska, and Slawomir Orzechowski. "Functional Analysis of Genes." Advances in Cell Biology 2, no. 1 (2010): 1–16. http://dx.doi.org/10.2478/v10052-010-0001-y.

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SummaryThe aim of this article is to present the current literature concerning the expression analysis and methods of functional characteristics of genes. The progress in the analysis of gene expression within cells or whole tissues is undisputed and leads to a constant improvement of our understanding of the function of particular gene. The traditional methods of the functional characteristics of genes such as homology, inactivation and overexpression are more frequently being replaced by microarray and DNA chip analysis, which are extensively supported by bioinformatics tools. Knowledge of t

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2

Jeong, Soon-Seog, and Ridong Chen. "Functional misassignment of genes." Nature Biotechnology 19, no. 2 (2001): 95. http://dx.doi.org/10.1038/84480.

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3

Scott, Rodney J. "Cancer genes: Functional aspects." European Journal of Cancer 33, no. 10 (1997): 1706–7. http://dx.doi.org/10.1016/s0959-8049(97)00259-1.

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4

Carpenter, D., R. S. McIntosh, R. J. Pleass, and J. A. L. Armour. "Functional effects of CCL3L1 copy number." Genes & Immunity 13, no. 5 (2012): 374–79. http://dx.doi.org/10.1038/gene.2012.5.

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5

Klee, Eric W., Stephen C. Ekker, and Lynda B. M. Ellis. "Target selection forDanio rerio functional genomics." genesis 30, no. 3 (2001): 123–25. http://dx.doi.org/10.1002/gene.1045.

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6

Montgomery, Nathan D. "Functional genomics: A rose by another name." genesis 33, no. 3 (2002): 140. http://dx.doi.org/10.1002/gene.10101.

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7

ABDULAZIZ, ABDUJABAR, and GURJA BELAY Dr. "A Review on Molecular and Cellular Basis of Plant-Parasitic Root Knot Nematode-Host Interactions: Host Resistance." International Journal of Recent Research in Life Sciences 9, no. 2 (2022): 46–63. https://doi.org/10.5281/zenodo.6527409.

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<strong>Abstracts:</strong> Root‐knot nematodes (RKN), (<em>Meloidogyne</em> spp.) are obligate endoparasites of more than 3000 species of plants, which results in $70 billion worth of economic loss every year, worldwide. Controlling of obligated plant parasitic rootknot-nematode is generally difficult and also with the banning of many nematicides chemicals that control nematode, because of adverse environmental impacts, it is recommended to develop host resistance genes. Although, many R-gene confer resistance to RKN have been identified, the majority of these gene lose durability o

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8

Purnell, Beverly A. "Functional screen for microcephaly genes." Science 370, no. 6519 (2020): 926.3–926. http://dx.doi.org/10.1126/science.370.6519.926-c.

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9

Camilleri, M., and A. R. Zinsmeister. "Candidate genes and functional dyspepsia." Neurogastroenterology & Motility 21, no. 1 (2009): 94. http://dx.doi.org/10.1111/j.1365-2982.2008.01205.x.

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10

Oliveira, Daniela M., and Margaret A. Goodell. "Transient RNA interference in hematopoietic progenitors with functional consequences." genesis 36, no. 4 (2003): 203–8. http://dx.doi.org/10.1002/gene.10212.

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11

Gujarati, Nehaben A., Alexandra R. Leonardo, Jessica M. Vasquez, et al. "Loss of Functional SCO2 Attenuates Oxidative Stress in Diabetic Kidney Disease." Diabetes 71, no. 1 (2021): 142–56. http://dx.doi.org/10.2337/db21-0316.

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Increased oxidative stress in glomerular endothelial cells (GEnCs) contributes to early diabetic kidney disease (DKD). While mitochondrial respiratory complex IV activity is reduced in DKD, it remains unclear whether it is a driver or a consequence of oxidative stress in GEnCs. Synthesis of cytochrome C oxidase 2 (SCO2), a key metallochaperone in the electron transport chain, is critical to the biogenesis and assembly of subunits required for functional respiratory complex IV activity. Here, we investigated the effects of Sco2 hypomorphs (Sco2KO/KI, Sco2KI/KI), with a functional loss of SCO2,

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12

Vudattu, N. K., I. Magalhaes, H. Hoehn, D. Pan, and M. J. Maeurer. "Expression analysis and functional activity of interleukin-7 splice variants." Genes & Immunity 10, no. 2 (2008): 132–40. http://dx.doi.org/10.1038/gene.2008.90.

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13

Troshchynsky, A., I. Dzneladze, L. Chen, Y. Sheng, V. Saridakis, and G. E. Wu. "Functional analyses of polymorphic variants of human terminal deoxynucleotidyl transferase." Genes & Immunity 16, no. 6 (2015): 388–98. http://dx.doi.org/10.1038/gene.2015.19.

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14

Wang, S., I. Adrianto, G. B. Wiley, et al. "A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus." Genes & Immunity 13, no. 5 (2012): 380–87. http://dx.doi.org/10.1038/gene.2012.6.

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15

Agrawal, N., and M. A. Brown. "Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases." Genes & Immunity 15, no. 8 (2014): 521–27. http://dx.doi.org/10.1038/gene.2014.46.

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16

Jones, Julie R., Kathy D. Shelton, Youfei Guan, Matthew D. Breyer, and Mark A. Magnuson. "Generation and functional confirmation of a conditional null PPAR? allele in mice." genesis 32, no. 2 (2002): 134–37. http://dx.doi.org/10.1002/gene.10042.

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17

Sokolowski, Marla B. "Functional testing of ASD-associated genes." Proceedings of the National Academy of Sciences 117, no. 1 (2019): 26–28. http://dx.doi.org/10.1073/pnas.1919695117.

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18

Cole, Shannon H., Ginger E. Carney, Colleen A. McClung, Stacey S. Willard, Barbara J. Taylor, and Jay Hirsh. "Two Functional but NoncomplementingDrosophilaTyrosine Decarboxylase Genes." Journal of Biological Chemistry 280, no. 15 (2005): 14948–55. http://dx.doi.org/10.1074/jbc.m414197200.

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19

Liebregts, T., B. Adam, and G. Holtmann. "Susceptibility genes and functional gastrointestinal disorders." Journal of Gastroenterology and Hepatology 20, no. 11 (2005): 1792–93. http://dx.doi.org/10.1111/j.1440-1746.2005.04163.x.

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20

Jeon, Hyejin, Younghoon Go, Minchul Seo, Won-Ha Lee, and Kyoungho Suk. "Functional Selection of Phagocytosis-Promoting Genes." Journal of Biomolecular Screening 15, no. 8 (2010): 949–55. http://dx.doi.org/10.1177/1087057110376090.

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Phagocytosis is a critical host defense mechanism that clears invading pathogens, apoptotic cells, and cell debris; it is an essential process for normal development, tissue remodeling, immune response, and inflammation. Here, a functional selection strategy was used to isolate novel phagocytosis-promoting genes. After the retroviral transfer of mouse brain cDNA library into NIH3T3 mouse fibroblast cells, cell sorting was used to select the cells that phagocytosed fluorescent zymosan particles. The cDNAs were retrieved from the selected cells and identified by DNA sequencing as eIF5A, Meg3, Tu

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21

Ichikawa, Naoya, and Tatsuhiko Kadowaki. "Functional analysis of mouse Mahya genes." Neuroscience Research 58 (January 2007): S51. http://dx.doi.org/10.1016/j.neures.2007.06.299.

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22

Burgess, Darren J. "Leveraging functional data for driver genes." Nature Reviews Genetics 16, no. 1 (2014): 5. http://dx.doi.org/10.1038/nrg3875.

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23

Weiner, David M., Matilda W. Goodman, Tonya M. Colpitts, et al. "Functional Screening of Drug Target Genes." American Journal of PharmacoGenomics 4, no. 2 (2004): 119–28. http://dx.doi.org/10.2165/00129785-200404020-00006.

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24

Stepanenko, A. A., Y. S. Vassetzky, and V. M. Kavsan. "Antagonistic functional duality of cancer genes." Gene 529, no. 2 (2013): 199–207. http://dx.doi.org/10.1016/j.gene.2013.07.047.

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25

Kiss-Toth, Endre, Eva E. Qwarnstrom, and Steven K. Dower. "Hunting for genes by functional screens." Cytokine & Growth Factor Reviews 15, no. 2-3 (2004): 97–102. http://dx.doi.org/10.1016/j.cytogfr.2004.02.002.

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26

Gao, Y., F. Lin, J. Su, et al. "Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells." Genes & Immunity 13, no. 1 (2011): 1–13. http://dx.doi.org/10.1038/gene.2011.77.

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27

Briggs, F. B. S., L. J. Leung, and L. F. Barcellos. "Annotation of functional variation within non-MHC MS susceptibility loci through bioinformatics analysis." Genes & Immunity 15, no. 7 (2014): 466–76. http://dx.doi.org/10.1038/gene.2014.37.

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28

Zhao, Ming, Cynthia R. Shirley, Shotaro Hayashi, et al. "Transition nuclear proteins are required for normal chromatin condensation and functional sperm development." genesis 38, no. 4 (2004): 200–213. http://dx.doi.org/10.1002/gene.20019.

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29

M. Zimmerman, Sarah, Roberta Besio, Melissa E. Heard-Lipsmeyer, et al. "Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm." AIMS Genetics 5, no. 1 (2018): 24–40. http://dx.doi.org/10.3934/genet.2018.1.24.

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30

Mrazek, F., A. Stahelova, E. Kriegova, et al. "Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis." Genes & Immunity 12, no. 6 (2011): 490–94. http://dx.doi.org/10.1038/gene.2011.27.

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31

Kłossowicz, M., K. Marek-Bukowiec, M. M. Arbulo-Echevarria, et al. "Identification of functional, short-lived isoform of linker for activation of T cells (LAT)." Genes & Immunity 15, no. 7 (2014): 449–56. http://dx.doi.org/10.1038/gene.2014.35.

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32

Nguyen, T. N., S. Baaklini, F. Koukouikila-Koussounda, et al. "Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population." Genes & Immunity 18, no. 3 (2017): 152–57. http://dx.doi.org/10.1038/gene.2017.13.

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33

Conde, Susana, Shahin Tavakoli, and Daphne Ezer. "Functional regression clustering with multiple functional gene expressions." PLOS ONE 19, no. 11 (2024): e0310991. http://dx.doi.org/10.1371/journal.pone.0310991.

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Gene expression data is often collected in time series experiments, under different experimental conditions. There may be genes that have very different gene expression profiles over time, but that adjust their gene expression patterns in the same way under experimental conditions. Our aim is to develop a method that finds clusters of genes in which the relationship between these temporal gene expression profiles are similar to one another, even if the individual temporal gene expression profiles differ. We propose a K-means-type algorithm in which each cluster is defined by a function-on-func

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34

Gul, Zareen, Muhammad Younas Khan Barozai, and Muhammad Din. "In-silico based identification and functional analyses of miRNAs and their targets in Cowpea (Vigna unguiculata L.)." AIMS Genetics 4, no. 2 (2017): 138–65. http://dx.doi.org/10.3934/genet.2017.2.138.

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35

De Santi, Chiara, Sucharitha Gadi, Agnieszka Swiatecka-Urban, and Catherine M. Greene. "Identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3’UTR." AIMS Genetics 5, no. 1 (2018): 53–62. http://dx.doi.org/10.3934/genet.2018.1.53.

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36

Early, S. B., P. Huyett, K. Brown-Steinke, L. Borish та J. W. Steinke. "Functional analysis of −351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-κB". Genes & Immunity 10, № 4 (2009): 341–49. http://dx.doi.org/10.1038/gene.2009.28.

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37

Eerligh, P., M. van Lummel, A. Zaldumbide, et al. "Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes." Genes & Immunity 12, no. 6 (2011): 415–27. http://dx.doi.org/10.1038/gene.2011.24.

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38

Nishijima, Ichiko, Alea Mills, Yi Qi, Michael Mills, and Allan Bradley. "Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome1p." genesis 36, no. 3 (2003): 142–48. http://dx.doi.org/10.1002/gene.10207.

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39

Brand, Cara L., and Mia T. Levine. "Functional Diversification of Chromatin on Rapid Evolutionary Timescales." Annual Review of Genetics 55, no. 1 (2021): 401–25. http://dx.doi.org/10.1146/annurev-genet-071719-020301.

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Repeat-enriched genomic regions evolve rapidly and yet support strictly conserved functions like faithful chromosome transmission and the preservation of genome integrity. The leading resolution to this paradox is that DNA repeat–packaging proteins evolve adaptively to mitigate deleterious changes in DNA repeat copy number, sequence, and organization. Exciting new research has tested this model of coevolution by engineering evolutionary mismatches between adaptively evolving chromatin proteins of one species and the DNA repeats of a close relative. Here, we review these innovative evolution-gu

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40

Zendo, Takeshi, Shun Iwatani, and Kenji Sonomoto. "Functional analysis of biosynthetic genes for bacteriocins." Japanese Journal of Lactic Acid Bacteria 30, no. 1 (2019): 18–26. http://dx.doi.org/10.4109/jslab.30.18.

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41

Kim, Tae Im, Byoung-Kuk Na, and Sung-Jong Hong. "Functional Genes and Proteins of Clonorchis sinensis." Korean Journal of Parasitology 47, Suppl (2009): S59. http://dx.doi.org/10.3347/kjp.2009.47.s.s59.

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42

Capellini, Alexandra, Matthew Williams, Kenan Onel, and Kuan-Lin Huang. "The Functional Hallmarks of Cancer Predisposition Genes." Cancer Management and Research Volume 13 (June 2021): 4351–57. http://dx.doi.org/10.2147/cmar.s311548.

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43

Rud, Daniel, Paul Marjoram, Kimberly Siegmund, and Darryl Shibata. "Functional human genes typically exhibit epigenetic conservation." PLOS ONE 16, no. 9 (2021): e0253250. http://dx.doi.org/10.1371/journal.pone.0253250.

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Recent DepMap CRISPR-Cas9 single gene disruptions have identified genes more essential to proliferation in tissue culture. It would be valuable to translate these finding with measurements more practical for human tissues. Here we show that DepMap essential genes and other literature curated functional genes exhibit cell-specific preferential epigenetic conservation when DNA methylation measurements are compared between replicate cell lines and between intestinal crypts from the same individual. Culture experiments indicate that epigenetic drift accumulates through time with smaller difference

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44

Crooijmans, R. P. M. A., J. J. Poel, and M. A. M. Groenen. "Functional genes mapped on the chicken genome." Animal Genetics 26, no. 2 (2009): 73–78. http://dx.doi.org/10.1111/j.1365-2052.1995.tb02636.x.

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45

SMITH, EUGENE J., HANS H. CHENG, and ROGER L. VALLEJO. "Mapping Functional Chicken Genes: An Alternative Approach." Poultry Science 75, no. 5 (1996): 642–47. http://dx.doi.org/10.3382/ps.0750642.

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46

Zhang, H., J. M. Maniar, and A. Z. Fire. "'Inc-miRs': functional intron-interrupted miRNA genes." Genes & Development 25, no. 15 (2011): 1589–94. http://dx.doi.org/10.1101/gad.2058711.

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47

Dannenfelser, Ruth, Neil R. Clark, and Avi Ma'ayan. "Genes2FANs: connecting genes through functional association networks." BMC Bioinformatics 13, no. 1 (2012): 156. http://dx.doi.org/10.1186/1471-2105-13-156.

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48

Lee, I. "A Probabilistic Functional Network of Yeast Genes." Science 306, no. 5701 (2004): 1555–58. http://dx.doi.org/10.1126/science.1099511.

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49

Cuperus, Josh T., Noah Fahlgren, and James C. Carrington. "Evolution and Functional Diversification of MIRNA Genes." Plant Cell 23, no. 2 (2011): 431–42. http://dx.doi.org/10.1105/tpc.110.082784.

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50

Terrazas, Sari, and Saumya Ramanathan. "Functional Characterization of X Antigen Genes (XAGEs)." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.05192.

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