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Journal articles on the topic 'Fungal Nail Infection'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Hartman, T. C. o., and E. v. Rijswijk. "Fungal nail infection." BMJ 337, jul10 3 (2008): a429. http://dx.doi.org/10.1136/bmj.39357.558183.94.

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2

Muth, Christopher C. "Fungal Nail Infection." JAMA 317, no. 5 (2017): 546. http://dx.doi.org/10.1001/jama.2016.20617.

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3

van der Weerden, Nicole L., Kathy Parisi, James A. McKenna, et al. "The Plant Defensin Ppdef1 Is a Novel Topical Treatment for Onychomycosis." Journal of Fungi 9, no. 11 (2023): 1111. http://dx.doi.org/10.3390/jof9111111.

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Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also have psychological and social consequences for the patient. Treatment of onychomycosis is complicated by the location of the infection under the nail plate, meaning that antifungal molecules must either penetrate the nail or be applied systemically. Currently, available treatments are limited by their poor nail penetration for topical products or their potential toxicity for systemic products. Plant defensins with potent antifungal activity have the potential to be safe and effective treatments for fungal

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4

Gaddime, Sonali B. Nagoba Shivappa N.* Suryawanshi S. R. Vijayendra Swamy S. M. "REVIEW ON TRANSUNGUAL: A NOVEL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 918–25. https://doi.org/10.5281/zenodo.2538345.

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<em>The nail disorders are mainly due to fungal infection. When the drug is given through oral or systemic route, the potency of drugs gets decreased at the site of action. To avoid this loss of drug potency topical route of administration is used. This review is mainly about transungual drug delivery which means transfer of drug across the keratinized nails to treat nail fungal diseases and increasing bioavailability of various drugs used for nail diseases. Nail diseases are mainly caused by fungal infections; fungi are most responsible for nail diseases. So treatment of such infections is no

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5

Kyriakou, Aikaterini, Sofia-Chrysovalantou Zagalioti, Myrto-Georgia Trakatelli, et al. "Fungal Infections and Nail Psoriasis: An Update." Journal of Fungi 8, no. 2 (2022): 154. http://dx.doi.org/10.3390/jof8020154.

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The relationship between psoriasis and onychomycosis is controversial, and the exact nature of this association remains to be clearly elucidated. In healthy nails, the compact nail plate acts as a barrier, preventing any infection. In psoriatic nails, the nail plate involvement, together with abnormalities in the blood capillaries, may lead to decreased natural defenses against microorganisms. Moreover, onycholysis (detachment of the nail plate) induces a humid environment that may favor fungal proliferation. Treatment with immunosuppressive drugs may additionally enhance onychomycosis. In thi

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Anggraini, Dwi Aprilia, and Norma Farizah Fahmi. "PENCEGAHAN PENYAKIT SISTEMIK PADA INFEKSI TINEA UNGUIUM KUKU PETANI DESA TRAGAH KABUPATEN BANGKALAN." JURNAL PARADIGMA (PEMBERDAYAAN & PENGABDIAN KEPADA MASYARAKAT) 4, no. 2 (2022): 14–19. http://dx.doi.org/10.36089/pgm.v4i2.735.

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Tinea unguinum is a common condition that begins as a yellow spot or spot under the tip of the fingernail or toenail. A severe fungal infection can cause the nail to blacken, thicken, and crumble at the edges. This infection can affect some nails but usually not all nails are infected. If the fungal infection of the nail is still relatively mild, it does not require treatment. But sometimes a nail fungus infection can cause pain and thickening of the nail that requires treatment and medication. Nail infections can attack someone who works or is in direct contact with a humid and dirty environm

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Greener, Mark. "Fungal infections: community nursing approaches to skin and nail care." British Journal of Community Nursing 30, no. 6 (2025): 274–78. https://doi.org/10.12968/bjcn.2025.0071.

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Dermatophytes (ringworms) are possibly the most prevalent causes of human infection globally. At least 40 dermatophyte species infect humans. For example, onychomycosis, which is responsible for about half of abnormal nails, may: produce ridging, ingrown nails, bleeding and nail loss; make walking painful; and facilitate secondary bacterial infections. Several diseases increase the risk of onychomycosis caused by dermatophytes, including knee osteoarthritis and poorly controlled diabetes. This article focuses on nursing approaches to managing skin and nail dermatophyte infections. Topical anti

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Brown, Anthony, Felipe Goñi-de-Cerio, Ainhoa Bilbao, et al. "An Assessment of the Antifungal Efficacy of a Novel Topical Onychomycosis Treatment Using Human Nail and Skin Infection Models." Journal of Fungi 11, no. 5 (2025): 345. https://doi.org/10.3390/jof11050345.

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Onychomycosis, a fungal nail infection, affects about 4% of the global population. Current topical antifungals like ciclopirox and amorolfine have limited effectiveness, highlighting the need for better treatments. WSNS-PO is a novel water-soluble therapy designed to treat and prevent onychomycosis by enhancing nail health. This study evaluated WSNS-PO’s ability to penetrate the nail plate and to treat and prevent infection by Trichophyton rubrum using bovine hoof membranes and human nail clippings. The anti-fungal efficacy of WSNS-PO was additionally evaluated against other dermatophytes, non

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9

Salomon, Joanna, Jacek C. Szepietowski, and Alina Proniewicz. "Psoriatic Nails: A Prospective Clinical Study." Journal of Cutaneous Medicine and Surgery 7, no. 4 (2003): 317–21. http://dx.doi.org/10.1007/s10227-002-0143-0.

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Background: Psoriasis is a widespread skin disorder in which nail involvement is a common symptom. Many psoriatic patients have nail changes morphologically resembling onychomycosis. Objective: The present study was undertaken (1) to evaluate the frequency of nail involvement in psoriatic patients, (2) to assess the types of nail changes in psoriasis, (3) to find eventual relationships between nail involvement and some clinical parameters, and finally (4) to determine the prevalence of fungal nail infections in psoriatic individuals. Material and Methods: One hundred six patients hospitalized

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10

Asdinar, Asdinar, Alya Ananda, and Aszrul AB. "Identification of Dermatophytes Causing Tinea Unguium in Fisherman in Tanah Lemo Subdistrict." Journal of Multidiscipline and Collaboration Research 1, no. 2 (2024): 91–98. https://doi.org/10.58740/jmcr.v1i2.283.

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Nail infection or tinea unguium is a disease caused by dermatophyte fungi and often occurs in fisherman due to their activities in wet environments without protection such as gloves or boots. Common symptoms found include nail damage, thickening, nail lifting, uneven broken nails, loss of shine, and discoloration to yellow, brown, or black. This study aims to identify the types of dermatophyte fungi that cause tinea unguium in fisherman in Tanah Lemo Village. This study used a qualitative approach with a fungal culture method using Saboraud Dextrose Agar (SDA) media and microscopic examination

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11

Karmila, I. Gusti Ayu Agung Dwi, I. Gusti Ayu Agung Praharsini, Ni Luh Putu Ratih Vibriyanti Karna, et al. "Tinea unguium in a child caused by Trichophyton rubrum: a case report." Bali Medical Journal 13, no. 3 (2024): 1472–76. https://doi.org/10.15562/bmj.v13i3.5205.

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Background: Nails are susceptible to fungal infections because they do not have effective cellular immunity. Onychomycosis describes a fungal infection of the nails caused by dermatophytes. The incidence of onychomycosis is increasing among children and adolescents. This case report will describe a nail fungal infection in a child and aims to improve understanding regarding tinea unguium clinical findings and treatment, especially in the pediatric population. Case: A 10-year-old Balinese girl complained of nail discoloration on her right index finger that initially appeared on the tip of the n

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12

Eisman, S., and R. Sinclair. "Fungal nail infection: diagnosis and management." BMJ 348, mar24 3 (2014): g1800. http://dx.doi.org/10.1136/bmj.g1800.

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13

Daniel, C. R. "The diagnosis of nail fungal infection." Archives of Dermatology 127, no. 10 (1991): 1566–67. http://dx.doi.org/10.1001/archderm.127.10.1566.

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14

Daniel, C. Ralph. "The Diagnosis of Nail Fungal Infection." Archives of Dermatology 127, no. 10 (1991): 1566. http://dx.doi.org/10.1001/archderm.1991.01680090130018.

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15

Ravindra Kumar, Sanju Pannu, Mukesh Kumar, and Om Prakash Yadav. "The Prevalence Onychomycosis in North Western Region of Rajasthan." International Healthcare Research Journal 1, no. 10 (2018): 323–29. http://dx.doi.org/10.26440/ihrj/01_10/139.

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NTRODUCTION: Onychomycosis is a fungal infection of nail caused by dermatophytes, yeast and mould. Onchomycosis infection continues to spread worldwide and found to persist everywhere. Onchomycosis infection prevalence is continuously increasing and the possible fungal pathogens are also increasing. All nail diseases are not fungal in origin hence laboratory investigations are needed to differentiate accurately between fungal infections and other conditions.AIM: to find out mycological profile & morphological identification of fungal agent in onchomycosis infection and their prevalence in

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Baranwal, Rimjhim, Debapriya Das Choudhury, Milind Ubale, Vaibhavi Nanoty, and Vishalakshi Vishwanath. "Clinico-mycological study of superficial mycoses and correlation with anti-fungal susceptibility among the Candida isolates in a teaching institution of Western India." Journal of Family Medicine and Primary Care 14, no. 7 (2025): 2660–65. https://doi.org/10.4103/jfmpc.jfmpc_625_24.

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ABSTRACT Introduction: Most common superficial fungal infection is caused by dermatophytes, which infects skin, hair, and nail in all age groups. Candida spp. is also a known causative agent for superficial mycoses. The prevalence also depends on different demographical variations. Aim and Objectives: The present study was conducted to isolate and identify the fungal species by phenotypic and culture methods from patients suffering from superficial fungal infections and establish in vitro anti-fungal susceptibility testing on candida isolates. Materials and Methods: The skin scrapings, hair, n

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17

Poulin, Yves, Richard Thomas, and Aditya K. Gupta. "Brief Treatment Guide for Onychomycosis." Journal of Cutaneous Medicine and Surgery 10, no. 6_suppl (2006): S39—S43. http://dx.doi.org/10.2310/7750.2006.00055.

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Most onychomycosis infections result from dermatophyte organisms and present as distal lateral subungual onychomycosis (DLSO). Mild to moderate infections may be effectively treated with topical lacquer medications; however, there is no general consensus on what constitutes mild infection. In general, mild infections involve relatively small areas of the nail plate without infection of the nail matrix or lunula. Characteristics such as nail thickness, the number of nails affected, and the degree of onycholysis will also be taken into account in the categorization of nail severity and may incre

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18

Mahajan, Mohita, and B. B. Mahajan. "Greenish discoloration due to gel nail extensions mimicking Pseudomonas aeruginosa infection: Is beauty really worth the risk: A case report." Cosmoderma 4 (September 30, 2024): 121. http://dx.doi.org/10.25259/csdm_135_2024.

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Over the past decades, the commercialization of nail cosmetics has increased. From nail polishes to artificial nails, different methods of nail beautification have emerged. Knowledge of the safety and efficacy of nail products is very important as nail products such as nail polish, nail polish removers, and artificial nails have several adverse effects. Harmful substances such as toluene sulfonamide-formaldehyde resin and methacrylates have been identified in commercial nail products, leading to several adverse effects, such as allergic contact dermatitis. Here, we report a case of a healthy y

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19

Monod, Michel, Olympia Bontems, Christophe Zaugg, Barbara Léchenne, Marina Fratti, and Renato Panizzon. "Fast and reliable PCR/sequencing/RFLP assay for identification of fungi in onychomycoses." Journal of Medical Microbiology 55, no. 9 (2006): 1211–16. http://dx.doi.org/10.1099/jmm.0.46723-0.

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Fusarium spp. and other non-dermatophyte fungi are repeatedly isolated from abnormal nails. To investigate whether these fungi are the aetiological agents of infection or simply transient contaminants, a PCR/sequencing/RFLP assay was developed for direct and routine identification of the infecting fungi in onychomycosis. Fungal DNA was readily extracted using a commercial kit after dissolving nail fragments in a Na2S solution. Amplification of part of the 28S rDNA by PCR was performed with universal primers and the fungal species were identified by sequencing. The PCR/sequencing results were c

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20

Avik, Ho Han, and Kyung Sohn Dae. "Pharmaceutical Perspectives on Fungal Infections: An In-Depth Review of Epidemiology and Pathology of Common Human Diseases." Pharmaceutical Care and Research 24, no. 1 (2024): 11–15. https://doi.org/10.5281/zenodo.11479561.

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In this article we studied about the common fungal infections that affect humans in this review essay. Fungal infections that result from fungal pathogens are found all over the world. Given the daily rise in fungal infections and illnesses, a thorough understanding of these infections is crucial, particularly for prevention and treatment. Google Scholar research papers and review articles from various journals provided the information regarding these fungal infections. Twelve common fungal infections that infect humans were covered, including aspergillosis, Blastomycosis, Candida auris infect

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Avik, Ho Han, and Kyung Sohn Dae. "Pharmaceutical Perspectives on Fungal Infections: An In-Depth Review of Epidemiology and Pathology of Common Human Diseases." Pharmaceutical Care and Research 24, no. 1 (2024): 11–15. https://doi.org/10.5281/zenodo.11529035.

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In this article we studied about the common fungal infections that affect humans in this review essay. Fungal infections that result from fungal pathogens are found all over the world. Given the daily rise in fungal infections and illnesses, a thorough understanding of these infections is crucial, particularly for prevention and treatment. Google Scholar research papers and review articles from various journals provided the information regarding these fungal infections. Twelve common fungal infections that infect humans were covered, including aspergillosis, Blastomycosis, Candida auris infect

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22

Sangeeta, Manjhi* Bishesar Sahu Kamini Sonwani Dhatri Sahu Munmun Bhattacharya. "A Review On: Onychomycosis a Fungal Nail Infection." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1644–52. https://doi.org/10.5281/zenodo.14245230.

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A typical nail fungal infection that can cause thickness, discolouration, and occasionally nail detachment is called onychomycosis. Dermatophytes, yeasts, and molds are the most common causes, and those with diabetes, weakened immune systems, or other medical disorders are more likely to have it. New topical treatments, such as tavaborole and efinaconazole, offer effective alternatives to older oral antifungals, with fewer side effects and improved cure rates. Diagnosis typically involves mycological testing, including microscopy and culture. Early diagnosis and appropriate treatment are key t

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23

Miller, John L. "Topical treatment approved for fungal nail infection." American Journal of Health-System Pharmacy 57, no. 3 (2000): 205. http://dx.doi.org/10.1093/ajhp/57.3.205a.

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LOPES, Jorge O., Sydney H. ALVES, Cristine R. D. MARI, et al. "A ten-year survey of onychomycosis in the Central Region of the Rio Grande do Sul, Brazil." Revista do Instituto de Medicina Tropical de São Paulo 41, no. 3 (1999): 147–49. http://dx.doi.org/10.1590/s0036-46651999000300002.

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Onychomycosis is a common infection of the nail plate caused by fungal microrganisms, and represents approximately 50% of nails disorders and 30% of all superficial mycotic infections. We present a study of the frequency, epidemiology and clinical aspects of onychomycosis in the central region of Rio Grande do Sul during the period 1988-1997.

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Cordoba Díaz, Damian, Marta Losa Iglesias, Ricardo Becerro de Bengoa Vallejo, and Manuel Cordoba Diaz. "Transungual Delivery of Ciclopirox Is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model." Pharmaceutics 11, no. 1 (2019): 29. http://dx.doi.org/10.3390/pharmaceutics11010029.

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Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow s

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Farizah Fahmi, Norma, and Aluf Thuti' Nashiha. "SKRINING ONIKOMIKOSIS PADA PETUGAS SAMPAH." JURNAL MEDICAL P-ISSN : 2685-7960 e-ISSN : 2685-7979 4, no. 1 (2024): 1–4. http://dx.doi.org/10.36089/jm.v4i1.2286.

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Onychomycosis is a fungal infection of the nail plate caused by dermatophyte, non-dermatophyte and yeast fungi. Onychomycosis causes damage to the nails, causing them to become thickened, brittle and easily destroyed. The factor causing nails to be infected with fungus is frequent direct contact with a humid and dirty environment. The purpose of this study was to determine the presence of Trichophyton sp., Aspergillus sp., Candida albicans fungal infections in the nails of waste officers at the Bangkalan District Environmental Service.The research method used was descriptive and the research d

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Munro, C. S., J. L. Rees, and S. Shuster. "The unexpectedly rapid response of fungal nail infection to short duration therapy." Acta Dermato-Venereologica 72, no. 2 (1992): 131–33. http://dx.doi.org/10.2340/0001555572131133.

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To test our hypothesis that, by laying down a fungicidal barrier in the growing nail, a short course of antifungal therapy should be effective against onychomycosis, we treated 8 subjects with Trichophyton rubrum nail infection with terbinafine 125 mg b.d. for 14 days. All but one patient showed marked improvement, and 80% of fingernails and 37% of toenails were clinically cured after 6 months. Although this confirmed our prediction, the onset of response measured by outward movement of affected nail and negative cultures from distal nail clippings occurred after as little as 4 weeks. This was

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Satish, Nithya, and CR Srinivas. "Nail as a carrier in patients with extensive tinea corporis – An observational analytical study." IP International Journal of Medical Microbiology and Tropical Diseases 8, no. 2 (2022): 140–44. http://dx.doi.org/10.18231/j.ijmmtd.2022.029.

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Dermatophytosis is a common infection which until recently used to respond satisfactorily to treatment, however clinical resistance is frequently encountered. The exact cause of treatment failure is not known. Neglecting the management of subclinical onychomycosis might be a possible cause for recurrence. This study was undertaken to detect the fungi in the nail plate and under the nail fold in patients without clinical evidence of onychomycosis. To detect the carrier state of nail plate and subungual region in patients with extensive dermatophytoses. Observational analytical study. Patients w

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Suprun, K. G., and I. O. Oliynyk. "Topical therapy of onychomycosis in patients with psoriasis." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 2 (June 29, 2021): 57–61. http://dx.doi.org/10.30978/ujdvk2021-2-57.

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Objective — to study the effectiveness of the method of treating onychomycosis using only local agents in patients suffering from psoriasis and having contraindications to the use of systemic antifungal agents. Materials and methods. The study involved 52 patients with psoriasis and lesions of the nail plates, aged 21 to 67 years. The duration of the disease was from 1 to 27 years.To verify the fungal infection of the nail plates, a microscopic examination of nail scales with 20 % KOH and molecular genetic studies using pan-fungal primers were carried out.Among 52 examined patients with

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Bulgheroni, Anna, Linda Frisenda, Alessandro Subissi, and Federico Mailland. "A Hydroxypropyl Chitosan (HPCH) Based Medical Device Prevents Fungal Infections: Evidences from an In Vitro Human Nail Model." Open Dermatology Journal 9, no. 1 (2015): 4–9. http://dx.doi.org/10.2174/1874372201509010004.

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A long lasting, protective and film forming HPCH-based medical device was developed and tested in a novel human nail infection model. HPCH-treated and untreated human distal fingernail fragments were disposed on the culture surface of or . After incubation for one or three weeks, the fragments were collected and histological analysis was performed. Results obtained in untreated nails evidenced, as expected, that the fungal invasion was different depending on the species: it was completed with spp., partial with sp. and limited to the surface with sp.. On the other hand, HPCH-treated nails were

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Mihalik, Noémi. "Onychomycosis." Bőrgyógyászati és Venerológiai Szemle 100, no. 4 (2024): 166–71. https://doi.org/10.7188/bvsz.2024.100.4.2.

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Onychomycosis is a common, chronic fungal nail infection affecting the toenails and fingernails. Causative agents are dermatophytes, yeasts and nondermatophyte moulds, however mixed infections can also occur. Microscopy and fungal culture are the gold standard techniques for onychomycosis diagnosis, however histology and PCR are also accurate methods. There are several treatment options available, including oral and topical antifungal drugs, and devices. Onychomycosis may cause physical dyscomfort and increase the risk for bacterial infections (erysipelas, cellulitis) in immunocompromised pati

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Botek, G. "Fungal nail infection: assessing the new treatment options." Cleveland Clinic Journal of Medicine 70, no. 2 (2003): 110–14. http://dx.doi.org/10.3949/ccjm.70.2.110.

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Chanyachailert, Pattriya, Charussri Leeyaphan, and Sumanas Bunyaratavej. "Cutaneous Fungal Infections Caused by Dermatophytes and Non-Dermatophytes: An Updated Comprehensive Review of Epidemiology, Clinical Presentations, and Diagnostic Testing." Journal of Fungi 9, no. 6 (2023): 669. http://dx.doi.org/10.3390/jof9060669.

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Cutaneous fungal infection of the skin and nails poses a significant global public health challenge. Dermatophyte infection, mainly caused by Trichophyton spp., is the primary pathogenic agent responsible for skin, hair, and nail infections worldwide. The epidemiology of these infections varies depending on the geographic location and specific population. However, epidemiological pattern changes have occurred over the past decade. The widespread availability of antimicrobials has led to an increased risk of promoting resistant strains through inappropriate treatment. The escalating prevalence

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Benedict, Kaitlin, Jeremy A. W. Gold, Karen Wu, and Shari R. Lipner. "High Frequency of Self-Diagnosis and Self-Treatment in a Nationally Representative Survey about Superficial Fungal Infections in Adults—United States, 2022." Journal of Fungi 9, no. 1 (2022): 19. http://dx.doi.org/10.3390/jof9010019.

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Data about the prevalence, diagnosis, treatment, and public knowledge of superficial fungal infections in the United States are scarce. These infections are a growing concern given the emergence of antifungal drug resistance. We analyzed data from a national survey of nearly 6000 U.S. adults. Overall, 114 (2.7%) participants reported having ringworm and 415 (10.0%) reported a fungal nail infection in the past 12 months; 61.4% of participants with any superficial fungal infection were self-diagnosed. Most patients (55.5%) used over-the-counter antifungals. The common nature of superficial funga

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Bitew, Adane, and Sinknesh Wolde. "Prevalence, Risk Factors, and Spectrum of Fungi in Patients with Onychomycosis in Addis Ababa, Ethiopia: A Prospective Study." Journal of Tropical Medicine 2019 (June 4, 2019): 1–6. http://dx.doi.org/10.1155/2019/3652634.

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Background. Onychomycosis is a common refractory infection deleteriously affecting quality of life via social stigma and upsetting day-to-day activities. Objective. To study the prevalence of onychomycosis, spectrum of fungal etiological agents, and associated risk factors. Methods. A prospective nonrandomized study on the prevalence of onychomycosis was carried out from September 2017 to April 2018 at a dermatology center in Addis Ababa. Nail scrapings were collected from 303 patients clinically identified with nail disorders of fungal origin by dermatologists. Fungal etiological agents were

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Akhtar, Nida, Hemlata Sharma, and Kamla Pathak. "Onychomycosis: Potential of Nail Lacquers in Transungual Delivery of Antifungals." Scientifica 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/1387936.

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Onychomycosis constitutes the most common fungal infection of the nail (skin beneath the nail bed) that affects the finger as well as toe nails. It is an infection that is initiated by yeasts, dermatophytes, and nondermatophyte molds. Nail lacquers are topical solutions intended only for use on fingernails as well as toenails and have been found to be useful in the treatment of onychomycosis. Thus, in the present review an attempt has been made to focus on the treatment aspects of onychomycosis and the ungual delivery of antifungals via nail lacquer. Several patents issued on nail lacquer till

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Scandorieiro, Sara, Natalia Rodrigues de Oliveira, Monique de Souza, et al. "Nail Lacquer Containing Origanum vulgare and Rosmarinus officinalis Essential Oils and Biogenic Silver Nanoparticles for Onychomycosis: Development, Characterization, and Evaluation of Antifungal Efficacy." Antibiotics 13, no. 9 (2024): 892. http://dx.doi.org/10.3390/antibiotics13090892.

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Onychomycosis is a common fungal nail infection for which new antifungals are needed to overcome antimicrobial resistance and the limitations of conventional treatments. This study reports the development of antifungal nail lacquers containing oregano essential oil (OEO), rosemary essential oil (REO), and biogenic silver nanoparticles (bioAgNPs). The formulations (F) were tested against dermatophytes using agar diffusion, ex vivo nail infection, and scanning electron microscopy techniques. They were evaluated for their pharmacotechnical characteristics and by FTIR-PAS to assess permeation acro

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Mandal, Debashree. "Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments." Oriental Journal Of Chemistry 40, no. 3 (2024): 630–45. http://dx.doi.org/10.13005/ojc/400302.

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Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth. According to their mode of action they are divided into azoles (inhibit ergosterol synthesis), echinocandins (damage cell walls), and polyenes (destroy fungal cells) etc. Depending on the seriousness of infection and type of infection, generally antifungal drugs are administered to a body. Oral antifungals are taken by mouth for systemic infections. Topical antifungals (creams, ointments) treat localized skin

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Sharma, M., and M. O'Brien. "Squamous cell carcinoma posing as a fungal nail infection." BMJ 350, jan28 3 (2015): h194. http://dx.doi.org/10.1136/bmj.h194.

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Kochergin, Nikolay G., and Ivan S. Maximov. "Prevalence and etiology of onychomycosis in patients with psoriasis: a single-center study." Russian Journal of Skin and Venereal Diseases 24, no. 1 (2021): 53–59. http://dx.doi.org/10.17816/dv61804.

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BACKGROUND: Changes in nails with psoriasis are observed in 8090% of patients. Pathological processes in the nail apparatus in patients with psoriasis are associated with both the underlying disease and the infectious nature. AIMS: To evaluate the clinical features of the affected nail plates in patients with psoriasis, the prevalence and etiology of onychomycosis in patients with psoriasis with altered nail plates. MATERIALS AND METHODS: 102 patients with psoriasis vulgaris, mild and moderate, stationary stage with altered nail plates were examined. A clinical and laboratory (micr

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Chularojanamontri, Leena, Penvadee Pattanaprichakul, Charussri Leeyaphan, Panittra Suphatsathienkul, Supisara Wongdama, and Sumanas Bunyaratavej. "Overall Prevalence and Prevalence Compared among Psoriasis Treatments of Onychomycosis in Patients with Nail Psoriasis and Fungal Involvement." BioMed Research International 2021 (December 13, 2021): 1–12. http://dx.doi.org/10.1155/2021/9113418.

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Background. Whether nail psoriasis can increase the risk of onychomycosis is still being debated, and data relating to the prevalence of onychomycosis among psoriasis patients receiving different treatments is limited. Objectives. To investigate the overall prevalence and prevalence compared among psoriasis treatments of onychomycosis in patients with nail psoriasis and fungal involvement. Methods. A prospective study of three groups of nail psoriasis being treated with only topical medication, methotrexate, or biologics (25 patients per group, 150 nails) was conducted at Siriraj Hospital (Ban

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Ghannoum, M. A., L. Long, N. Isham, et al. "Ability of Hydroxypropyl Chitosan Nail Lacquer To Protect against Dermatophyte Nail Infection." Antimicrobial Agents and Chemotherapy 59, no. 4 (2014): 1844–48. http://dx.doi.org/10.1128/aac.04842-14.

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ABSTRACTThe development of a topical agent that would strengthen the nail, improve the natural barrier, and provide better drug penetration to the nail bed is needed. In this study, we examined the effects of a hydroxypropyl chitosan (HPCH)-based nail solution using a bovine hoof model. Following application of the nail solution, changes in the hardness of the hoof samples were measured using the Vickers method. Tensile and flexural strengths were tested by stretching or punching the samples, respectively. The ultrastructure was examined using scanning electron microscopy (SEM), and samples st

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Markinson, Bryan, Mahmoud Ghannoum, Tate Winter, Anthony Rycerz, Fernando Rock, and Aditya K. Gupta. "Examining the Benefits of the Boron-Based Mechanism of Action and Physicochemical Properties of Tavaborole in the Treatment of Onychomycosis." Journal of the American Podiatric Medical Association 108, no. 1 (2018): 12–19. http://dx.doi.org/10.7547/16-154.

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Onychomycosis is a fungal infection of the nail primarily caused by the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. The topical-based treatment of onychomycosis remains a challenge because of the difficulty associated with penetrating the dense, protective structure of the keratinized nail plate. Tavaborole is a novel small-molecule antifungal agent recently approved in the United States for the topical treatment of toenail onychomycosis. The low molecular weight, slight water solubility, and boron chemistry of tavaborole maximize nail penetration after topical applicati

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Cunha, Nélia, Célia Galhardas, Margarida Apetato, and André Lencastre. "Toenail Changes in Patients with Diabetes Mellitus with and Without Onychomycosis." Journal of the American Podiatric Medical Association 108, no. 5 (2018): 370–74. http://dx.doi.org/10.7547/17-006.

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Background: Diabetes mellitus is a predisposing factor for onychomycosis (OM). A high frequency of nonfungal onychodystrophy (OD) is also alleged, although information on the prevalence of specific nail changes is scant. We evaluated the prevalence and types of nail changes in a cohort of diabetic patients with fungal and nonfungal OD. Methods: During a 6-month period, inpatients with diabetes mellitus were screened for foot and toenail changes. Demographic, social, and clinical data were recorded, as was information concerning foot and toenail care. Fungal infection was confirmed by mycologic

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Kawther Mohammed Radah Ali. "Effect of Topical Curcumin on Tinea Unguium." Academic International Journal of Medical Update 1, no. 1 (2023): 11–14. http://dx.doi.org/10.59675/u113.

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Onychomycosis is one of the prevalent fungal infections that occur in the nails, and this paper has straight forwardly discussed this fungal infection. Fungal infection of the nail is a worldwide infestation caused by a specific fungal family known as tinea unguium. Although it is not a serious condition, its treatment may be prolonged with an optimal medical approach and, if not treated well, may induce disseminated fungal spread to other skin sites and cause cosmetic deformities. Curcumin is a well-known plant extract that has been used for many centuries for many purposes like cooking and c

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Saud, Bhuvan, Prajuna Bajgain, Govinda Paudel, et al. "Fungal Infection among Diabetic and Nondiabetic Individuals in Nepal." Interdisciplinary Perspectives on Infectious Diseases 2020 (November 18, 2020): 1–7. http://dx.doi.org/10.1155/2020/7949868.

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Background. Low immunity, comorbid clinical conditions, and metabolic disorders may be the underlying factors that determine the severity of infection. Diabetes increases the risk of infection and multiple organ damage. In Nepal, the actual burden of fungal infections has not been estimated or is in a limited progress. This study aimed to investigate the status of fungal infection in diabetic and nondiabetic individuals in Bhaktapur, Nepal. Materials and Methods. A total of 670 samples were collected from 134 participants. From each participant, five samples were collected from different sites

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Salahudeen, Mohamed, Anita Ramdas, Arthi Elumalai, Kandasamy Ravichandran, and Sheela Kuruvila. "Efficacy of periodic acid–Schiff stain in the diagnosis of onychomycosis – A cross-sectional study." Journal of Current Research in Scientific Medicine 8, no. 1 (2022): 32–36. http://dx.doi.org/10.4103/jcrsm.jcrsm_3_22.

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Background: Onychomycosis is the fungal infection of the nail which needs to be differentiated from other causes of dystrophic nails due to its long-term treatment. Direct microscopic examination with potassium hydroxide (KOH) mount along with fungal culture shows inconsistent sensitivity. Thus, there is a need of more accurate and efficient method to detect onychomycosis. Aims and Objectives: This study aims to compare periodic acid–Schiff (PAS) stain with KOH and nail fungal culture in the diagnosis of onychomycosis. Materials and Methods: This was a cross-sectional study conducted in the de

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Jaishi, Vidya Laxmi, Ranjana Parajuli, Pragyan Dahal, and Roshani Maharjan. "Prevalence and Risk Factors of Superficial Fungal Infection among Patients Attending a Tertiary Care Hospital in Central Nepal." Interdisciplinary Perspectives on Infectious Diseases 2022 (October 4, 2022): 1–10. http://dx.doi.org/10.1155/2022/3088681.

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Fungal infections of hair, nail, and skin are common worldwide and tend to increase. The present study was conducted to determine the prevalence of dermatomycoses, estimate the efficiency of rapid potassium hydroxide (KOH) wet-mount, and observe the hygienic status and the predisposing risk factors. Altogether 115 samples (nail = 77, skin = 30, and hair = 8) were obtained in a duration of December 2019 to June 2020 at Grande International Hospital, Nepal. The samples were examined by KOH wet-mount microscopy and further processed for culture. The dermatophyte test medium (DTM) was used to isol

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Arabadzhyan, M. I., and R. Yu Mayorov. "Overview of hardware methods of treatment of onychomycosis (literature review)." Medical alphabet 1, no. 27 (2022): 7–10. http://dx.doi.org/10.33667/2078-5631-2022-27-7-10.

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Introduction. Treatment of fungal infection of nail plates is associated with a number of difficulties, such as high expectations, low patient compliance to long-term therapy, irrational selection of antifungal drugs and, as a consequence, the development of resistance. Currently, there are many hardware methods of treating onychomycosis, which can significantly accelerate recovery and increase the effectiveness of therapy. Discussion. The article describes such methods of physiotherapeutic treatment of fungal nail infection as laser technology, low-temperature plasma, photodynamic therapy, io

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Shikha, Rashmi, Dheeraj Bisht, Manoj Bhardwaj, and Manoj Bisht. "Formulation and Evaluation of Terbinafine HCL loaded Nanoparticles for Transungual delivery of drug in Fungal infection." Journal of Neonatal Surgery 14, no. 28S (2025): 383–402. https://doi.org/10.63682/jns.v14i28s.6615.

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In this review we mainly concern about the transungual delivery of drug to treat nail infection which is caused by the infection of a fungus. Transungual drug delivery is regarded as a very desirable treatment for various diseases in nail treatment due to its localized effects, which promote adherence while causing less unfavorable systemic effects. The nail is one of the toughest portions of the human body, and the nail plate presents a challenging barrier for drugs moiety to pass through . Topical medication delivery treatment is useful for treating numerous nail problems since it has locali

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