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Journal articles on the topic 'Fungicidal assay'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rabjohns, Jennifer L. A., Yoon-Dong Park, Jean Dehdashti, et al. "A High-Throughput Screening Assay for Fungicidal Compounds against Cryptococcus neoformans." Journal of Biomolecular Screening 19, no. 2 (2013): 270–77. http://dx.doi.org/10.1177/1087057113496847.

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Cryptococcus neoformans is a pathogenic fungus that causes meningitis worldwide, particularly in human immunodeficiency virus (HIV)–infected individuals. Although amphotericin B is the “gold standard” treatment for cryptococcal meningitis, the toxicity and inconvenience of intravenous injection emphasize a need for development of new anticryptocccal drugs. Recent data from humans and animal studies suggested that a nutrient-deprived host environment may exist in cryptococcal meningitis. Thus, a screening assay for identifying fungicidal compounds under nutrient-deprived conditions may provide

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Niu, Bing, Wan Huai, Zhirui Deng, and Qin Chen. "Fungicidal, Corrosive, and Mutational Effects of Polyhexamethylene Biguanide Combined with 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/4357031.

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Background. The disinfectants polyhexamethylene biguanide (PHMB) and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) each have limitations. So far, their combined usage has not been examined. In this study, the fungicidal activity of combined disinfectant using PHMB and BCDMH, named PB, against Candida albicans was evaluated. Methods. Suspension quantitative fungicidal test and viable fungi count were used to test fungicidal effects against C. albicans. Coupon corrosion testing was used to evaluate disinfectants’ corrosive effects on stainless steel, copper, and aluminum. The mous

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Dyląg, Mariusz, Artur Sawicki, and Rafał Ogórek. "Diversity of Species and Susceptibility Phenotypes toward Commercially Available Fungicides of Cultivable Fungi Colonizing Bones of Ursus spelaeus on Display in Niedźwiedzia Cave (Kletno, Poland)." Diversity 11, no. 12 (2019): 224. http://dx.doi.org/10.3390/d11120224.

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Underground ecosystems are one of the most inhospitable places for microorganism development and function. Therefore, any organic matter located in these areas can stimulate fungal growth. The main purpose of this study was to find the best solution to effectively preserve (without relapses) paleolithic bones of cave bear (Ursus spelaeus) exhibited in cave without any negative influence on the cave environment. To achieve this aim, unambiguous identification of fungal species and its susceptibility tests toward fungicidal preparations were performed. Fungi were identified based on phenotypic t

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Cavalcanti, Bruno Bezerra, Hermes Diniz Neto, Walicyranison Plinio da Silva-Rocha, et al. "Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp." Research, Society and Development 10, no. 15 (2021): e35101522434. http://dx.doi.org/10.33448/rsd-v10i15.22434.

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The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 µg/mL against both species assay. And the MFC was 512 µg/mL, demonstrated nature fungicidal (MFC/MIC < 4). In addition, combination of a

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5

Terleckyj, B., and D. A. Axler. "Quantitative neutralization assay of fungicidal activity of disinfectants." Antimicrobial Agents and Chemotherapy 31, no. 5 (1987): 794–98. http://dx.doi.org/10.1128/aac.31.5.794.

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Aslam, Saman, Muhammad U. Ghazanfar, Nida Munir, and Muhammad I. Hamid. "MANAGING FUSARIUM WILT OF PEA BY UTILIZING DIFFERENT APPLICATION METHODS OF FUNGICIDES." Pakistan Journal of Phytopathology 31, no. 1 (2019): 81–88. http://dx.doi.org/10.33866/phytopathol.031.01.0482.

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Fusarium wilt of pea is an ubiquitous disease of pea in all peas growing areas. The disease is able to cause hundred percent yield losses under favorable conditions. Multiple management approaches are in use to control this soil pathogen on different growth stages of crop, in which chemical control is providing quick response. This study was designed to evaluate different fungicides and their application methods to inhibit the pathogenic growth and development. Moreover, minimum effective concentration of fungicides against wilt disease of pea was also evaluated. Both in vitro and in vivo bio

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Vallières, Cindy, Cameron Alexander, and Simon V. Avery. "Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations." Applied Microbiology and Biotechnology 105, no. 7 (2021): 2867–75. http://dx.doi.org/10.1007/s00253-021-11211-3.

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Abstract Fungi cause diverse, serious socio-economic problems, including biodeterioration of valuable products and materials that spawns a biocides industry worth ~$11 billion globally. To help combat environmental fungi that commonly colonise material products, this study tested the hypothesis that combination of an approved fungicide with diverse agents approved by the FDA (Food and Drug Administration) could reveal potent combinatorial activities with promise for fungicidal applications. The strategy to use approved compounds lowers potential development risks for any effective combinations

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8

Mat Jalil, Mohd Taufiq, Nabila Husna Hairudin, and Darah Ibrahim. "Muscodor sp. IBRL OS-94, A Promising Endophytic Fungus of Ocimum sanctum with Antimicrobial Activity." Pharmaceutical Sciences 27, no. 2 (2020): 268–80. http://dx.doi.org/10.34172/ps.2020.79.

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Background: An endophytic fungus, Muscodor sp. IBRL OS-94 isolated from the leaf of Ocimum sanctum was believed to possess significant antimicrobial activity and several assays were carried out to evaluate its pharmaceutical potential. Methods: Agar plug diffusion and the disk diffusion assays were performed to evaluate the antimicrobial activity of the fungal extract. Also, the broth microdilution assay was done to investigate the minimum inhibitory concentration (MIC) of the fungal extract. Meanwhile, the scanning electron microscope (SEM) was employed to observe the structural degeneration

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9

Pettit, Robin K., George R. Pettit, and Kevin C. Hazen. "Specific Activities of Dolastatin 10 and Peptide Derivatives against Cryptococcus neoformans." Antimicrobial Agents and Chemotherapy 42, no. 11 (1998): 2961–65. http://dx.doi.org/10.1128/aac.42.11.2961.

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ABSTRACT The biosynthetic peptide dolastatin 10 is currently in phase I and II cancer clinical trials. We evaluated the antifungal spectrum of dolastatin 10 and four structural modifications. In broth macrodilution assays, the peptides were fungicidal for American Type Culture Collection strains and clinical isolates (including fluconazole-resistant strains) of Cryptococcus neoformansbut no other yeasts or filamentous fungi examined. Specificity forC. neoformans was also demonstrated in the solid-phase disk diffusion assay, and fungicidal activity was confirmed in time-kill experiments. For a

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10

Krysan, Damian J., and Louis Didone. "A High-Throughput Screening Assay for Small Molecules That Disrupt Yeast Cell Integrity." Journal of Biomolecular Screening 13, no. 7 (2008): 657–64. http://dx.doi.org/10.1177/1087057108320713.

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Lead compounds for antifungal drug development are urgently needed because invasive fungal infections are an important cause of morbidity and mortality in immunocompromised patients. Here, a high-throughput screening assay for small molecules that cause yeast cell lysis is described. The assay is based on the detection of the intracellular enzyme adenylate kinase in the culture medium as a reporter of yeast cell lysis. Features of the assay protocol include 1) the ability to detect cell lysis at drug concentrations that cause no apparent growth defect, 2) specificity for fungicidal molecules,

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Chen, Shu, Dong-Lin Zhang, Chao-Li Ren, et al. "Novel Pyridyl–Oxazole Carboxamides: Toxicity Assay Determination in Fungi and Zebrafish Embryos." Molecules 26, no. 13 (2021): 3883. http://dx.doi.org/10.3390/molecules26133883.

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Eight novel pyridyl–oxazole carboxamides were evaluated against fungi and displayed good fungicidal activities against Botrytis cinereal and Rhizoctonia solani. Preliminary bioassay results indicated that at 100 mg/L, compounds 6a–6e, 6g and 6h exhibited 100% fungicidal activities against Botrytis cinerea, and the compound 6b to Rhizoctonia solani at 100%. Then, the zebrafish embryo acute toxicity test was performed to assess the toxicity of 6b and 6c. A series of malformations appeared, when the zebrafish embryos were exposed to 6b and 6c, such as delayed yolk sac resorption, significant shor

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Meletiadis, Joseph, Charalampos Antachopoulos, Theodouli Stergiopoulou, Spyros Pournaras, Emmanuel Roilides, and Thomas J. Walsh. "Differential Fungicidal Activities of Amphotericin B and Voriconazole against Aspergillus Species Determined by Microbroth Methodology." Antimicrobial Agents and Chemotherapy 51, no. 9 (2007): 3329–37. http://dx.doi.org/10.1128/aac.00345-07.

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ABSTRACT Antifungal agents may differ in their fungicidal activities against Aspergillus spp. In order to compare the fungicidal activities of voriconazole and amphotericin B against 40 isolates of Aspergillus fumigatus, A. flavus, and A. terreus, we developed a new microbroth colorimetric method for assessing fungicidal activities and determining minimal fungicidal concentrations (MFCs). This methodology follows the antifungal susceptibility testing reference method M-38A for MIC determination. After drug removal and addition of fresh medium, growth of viable conidia adhering to the bottoms o

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Bhade, M. W. "Antifungal Assay of some Novel Chalcone Derivatives." Current Agriculture Research Journal 11, no. 1 (2023): 258–64. http://dx.doi.org/10.12944/carj.11.1.22.

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Numerous heterocyclic compounds demonstrated a wide range of biological activities, including pesticidal, fungicidal, insecticidal, antioxidant, and analgesic properties. The majority of heterocycles have outstanding antitubercular, anticancer, and antimicrobial properties. These actions were documented by the researchers in both in-vitro and in-vivo settings. So we undertake the antifungal assay of synthesized compounds against some pathogens viz Candida albicans, Trichophyton rubrum, Aspergillus niger, and Trichophyton mentagoforum which are mainly responsible for the diseases in ornamental

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14

Fukuda, T., W. Naka, S. Tajima, and T. Nishikawa. "Neutral red assay in minimum fungicidal concentrations of antifungal agents." Medical Mycology 34, no. 5 (1996): 353–56. http://dx.doi.org/10.1080/02681219680000601.

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15

Janani, Manoharan, Anbumani Devipriya, Dhandapani Kayal Vizhi, and Ranganathan Babujanarthanam. "Antioxidant, Antifungal and Cytotoxic Impact of Acacia nilotica Bark Aqueous Extract." International Journal of Zoological Investigations 08, no. 02 (2022): 735–46. http://dx.doi.org/10.33745/ijzi.2022.v08i02.089.

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The medicative plants were copiously applied in the healing of health complications. Traditionally implemented, medicative-worthy Acacia nilotica (Fabaceae family), is applied globe-wide in customary healing practices. Here, we have tried to unravel the antioxidant, fungicidal, antibacterial and cytotoxic trait of A. nilotica bark aqueous extract. Phyto-content testing revealed presence of flavonoids, tannins, alkaloids, phenols, carbohydrates, proteins, and amino acids. The antioxidant efficacies were 39.12 µg/ml (for DPPH assay) and 42.64 µg/ml (for NO assay) as IC50 ranges, respectively. Th

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16

Moret, A., M. Nadal, and Z. Muñoz. "ASSAY OF THE FUNGICIDAL ACTION OF ACETYLSALICYLIC ACID ON BOTRYTIS CINEREA." Acta Horticulturae, no. 754 (October 2007): 367–72. http://dx.doi.org/10.17660/actahortic.2007.754.48.

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17

Abdul, Hadi Nisar Ahmed Shahwani Tahira Bano Syed Qasim Shah. "DETERMINATION OF PHYTOCHEMICAL COMPOSITION OF HELLIOTROPIUM DASYCARPUM: ANTIBACTERIAL AND ANTIFUNGAL ASSAY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6617–21. https://doi.org/10.5281/zenodo.1318619.

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<em>The purpose of the current study is to determine the phytochemicals, antibacterial activity and antifungal activity of the plant Helliotropium dasycarpum obtained from Baluchistan province of Pakistan. Helliotropium dasycarpum which is an herb is situated in different regions of Baluchistan, Pakistan. Various solvents are applied for the extraction of the plant and its members in various studies, with Methanolic extract being the very popular solvent. When subjected to phytochemical test, it was revealed that the plant contains alkaloids, saponins, pyhtosteroles, phenols tannins, ditepenes

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18

Manzano, Joe Anthony H., Simone Brogi, Vincenzo Calderone, Allan Patrick G. Macabeo, and Nicanor Austriaco. "Globospiramine Exhibits Inhibitory and Fungicidal Effects against Candida albicans via Apoptotic Mechanisms." Biomolecules 14, no. 6 (2024): 610. http://dx.doi.org/10.3390/biom14060610.

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Candidiasis is considered an emerging public health concern because of the occurrence of drug-resistant Candida strains and the lack of an available structurally diverse antifungal drug armamentarium. The indole alkaloid globospiramine from the anticandidal Philippine medicinal plant Voacanga globosa exhibits a variety of biological activities; however, its antifungal properties remain to be explored. In this study, we report the in vitro anticandidal activities of globospiramine against two clinically relevant Candida species (C. albicans and C. tropicalis) and the exploration of its possible

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19

Rammal, Marwa, Salam Khreiss, Adnan Badran, et al. "Antibacterial and Antifungal Activities of Cimbopogon winterianus and Origanum syriacum Extracts and Essential Oils against Uropathogenic Bacteria and Foodborne Fungal Isolates." Foods 13, no. 11 (2024): 1684. http://dx.doi.org/10.3390/foods13111684.

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Abstract: This study focused on testing the antibacterial and antifungal activity of Origanum syriacum (O. syriacum) and Cimbopogon winterianus (C. winterianus) extracts and their essential oils (EOs). The bacteria were isolated from urine samples and identified by a VITEK assay, and the fungi were isolated from spoiled food samples and further identified by MALDI-TOF. The susceptibility of the microbial isolates was assessed by determining the bacteriostatic and bactericidal/fungicidal effects by the minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC

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Wang, Luo-Jing, Zong-Yan Ma, Xin-Ling Wang, et al. "New Chaetoglobosins with Fungicidal Activity from Chaetomium sp. UJN-EF006 Endophytic in Vaccinium bracteatum." Journal of Fungi 11, no. 7 (2025): 511. https://doi.org/10.3390/jof11070511.

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Nine chaetoglobosins (1–9) including five previously undescribed ones (1–5) were obtained from the culture broth of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites were elucidated by spectroscopic methods including mass spectroscopy, nuclear magnetic resonance, single crystal X-ray crystallography, and electronic circular dichroism. To accelerate the development of novel fungicides, all of the isolated chaetoglobosins were evaluated for their antifungal activity against two crop pathogens, Botrytis cin

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Lunde, Christopher S., and Isao Kubo. "Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae." Antimicrobial Agents and Chemotherapy 44, no. 7 (2000): 1943–53. http://dx.doi.org/10.1128/aac.44.7.1943-1953.2000.

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ABSTRACT The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae. In an acidification assay, polygodial completely suppressed the glucose-induced decrease in external pH at 3.13 μg/ml, the same as the fungicidal concentration. Acidification occurs primarily through the proton-pumping action of the plasma membrane ATPase, Pma1p. Surprisingly, this ATPase was not directly inhibited by polygodial. In contrast, the two other membrane-bound ATPases in yeast were found to be susceptible to the compound. The mitochondrial AT

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De Oliveira, Michael Éder, William Gustavo De Lima, Carla Ferreira Bruno Alves, et al. "Synergetic action of atorvastatin and fluconazole against fluconazole-resistant Candida albicans in vitro and in a murine model for intra-abdominal Candidiasis / Ação sinérgica da atorvastatina e fluconazol contra Candida albicans resistente ao fluconazol in vitro e em um modelo murino contra Candidíase intra-abdominal." Brazilian Journal of Development 8, no. 5 (2022): 41115–37. http://dx.doi.org/10.34117/bjdv8n5-543.

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Introduction: Candida albicans is the most common causative agent of Intra-abdominal Candidiasis (IAC) and it is resistant to most antifungal drugs currently available. Here we investigated atorvastatin in vitro and in vivo antifungal activities against a fluconazole-resistant C. albicans strain as a potential repurposed drug. The following tests were carried out: antifungal susceptibility tests to determine minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), determination of time-kill curve, biofilm assays, Candida albicans yeast-hyphae transition inhibition ass

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Z., Fazly-Ann, Nor-Hafizah M.Y., and Yaya Rukayadi. "Antifungal activity of Piper cubeba L. extract on spoilage fungi isolated from tomato, grapes and lemon." Food Research 4, no. 1 (2019): 191–98. http://dx.doi.org/10.26656/fr.2017.4(1).278.

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The berries of Piper cubeba L. or commonly recognized as tailed pepper are traditionally used as flavoring ingredients in various types of food. It has been reported with abundant of phytochemical compounds that contribute to its nutritional and medicinal properties. The antimicrobial effect of the spice including antifungal activity was believed to reduce the potential of fungal spoilage thus minimizing food losses and wastage. This study was aimed to determine the antifungal activity of P. cubeba L. extract against isolated spoilage fungi namely Geotricum candidum (TMa 001), Penicillium citr

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Wang, Xiaoning, David E. Wedge, Nurhayat Tabanca, et al. "Development of a Miniaturized 24-well Strawberry Leaf Disk Bioassay for Evaluating Natural Fungicides." Natural Product Communications 3, no. 7 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300709.

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There is great incentive to discover biologically active natural products from higher plants that are more effective than synthetic agrochemicals and are environmentally safe. Research emphasis at the US Department of Agriculture has therefore been on the development of alternative approaches to utilizing natural plant products in pest management. Discovery and evaluation of natural product fungicides is largely dependent upon the availability of miniaturized antifungal bioassays. We report on the development of a miniaturized 24-well leaf disk assay for evaluating plant extracts and pure comp

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Fernandes, Chantal, José Sousa-Baptista, Ana Filipa Lenha-Silva, et al. "Azorean Black Tea (Camellia sinensis) Antidermatophytic and Fungicidal Properties." Molecules 28, no. 23 (2023): 7775. http://dx.doi.org/10.3390/molecules28237775.

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The treatment of dermatophytoses, the most common human fungal infections, requires new alternatives. The aim of this study was to determine the antidermatophytic activity of the aqueous Azorean Black Tea extract (ABT), together with an approach to the mechanisms of action. The phytochemical analysis of ABT extract was performed by HPLC. The dermatophytes susceptibility was assessed using a broth microdilution assay; potential synergies with terbinafine and griseofulvin were evaluated by the checkerboard assay. The mechanism of action was appraised by the quantification of the fungal cell wall

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Ali, Javid, and Javed Abbas. "Comparative bioactive compounds and antifungal potential evaluation of Mentha longifolia (L.) Hudson (Lamiaceae) extracts against plant pathogenic fungi." International Journal of Engineering, Science and Technology 15, no. 2 (2023): 48–57. http://dx.doi.org/10.4314/ijest.v15i2.5.

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The present study was design to evaluate the Mentha longifolia stem, flower and leaves infusion, decoction and hydroalcoholic extracts to determine the bioactive molecules and antifungal activities by zone of inhibition technique, Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were assay by broth dilution technique and spore germination assay using Light Compound Microscope against plant pathogenic fungi (Fusarium oxysporum, Aspergillus parasiticus, Rhizoctonia solani and Alternaria alternata). The Mentha longifolia phytochemicals were found in the range flav

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Walek, Wolfgang, Christine Fieseler, Peter Schneider, and Gerhard W. Fischer. "Notizen: Trennung und biologische Wirksamkeit der Enantiomeren eines chiralen Thiadiazolylsulfoxides/Separation and Biological Activity of the Enantiomers of a Chiral Thiadiazolyl Sulfoxide." Zeitschrift für Naturforschung B 47, no. 4 (1992): 597–99. http://dx.doi.org/10.1515/znb-1992-0424.

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The enantiomers of the fungicidal and bactericidal (3-chloro-1,2,4-thiadiazol-5-yl)-(3´-chloro-1´,2´,4´-thiadiazoyl-5´-ylthiomethyl)-sulfoxide (2) have been separated by liquid chromatography on triacetylcellulose. Tested in a photometer assay on Torulopsis H 24 and Erwinia carotovorum (+)-2 and (-)-2 show practically the same activity and do not differ from the racemic mixture.

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Del Gaudio, Gaetano, Lisa Lombardi, Giuseppantonio Maisetta, et al. "Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid." Antimicrobial Agents and Chemotherapy 57, no. 9 (2013): 4314–21. http://dx.doi.org/10.1128/aac.00904-13.

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ABSTRACTVaginal infections caused byCandida glabrataare difficult to eradicate due to this species' scarce susceptibility to azoles. Previous studies have shown that the human cationic peptide hepcidin 20 (Hep-20) exerts fungicidal activity in sodium phosphate buffer against a panel ofC. glabrataclinical isolates with different levels of susceptibility to fluconazole. In addition, the activity of the peptide was potentiated under acidic conditions, suggesting an application in the topical treatment of vaginal infections. To investigate whether the peptide activity could be maintained in biolog

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Akhlaq, Muhammad, Hafiz Muhammad Usman Abid, Muhammad Sajid, et al. "Antioxidant, Immunomodulatory and Fungicidal Potential of Different Extracts of Raphanus Raphanistrum L. Var. Caudatus." Journal of Health and Rehabilitation Research 4, no. 1 (2024): 646–51. http://dx.doi.org/10.61919/jhrr.v4i1.441.

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Background: Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, emphasizing the importance of antioxidants in maintaining cellular homeostasis. Raphanus raphanistrum, commonly known as wild radish, has been traditionally used for its medicinal properties, including antioxidant, immunomodulatory, and antifungal effects. The plant is rich in bioactive compounds such as flavonoids, isothiocyanates, and vitamins, which contribute to its therapeutic potential. Objective: This study aimed to evaluate the antioxidant, immunomodulatory, and antifungal activities

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Poester, Vanice Rodrigues, Jéssica Estefania Dávila Hidalgo, Lara Severo Jardim, et al. "Amlodipine and lufenuron as repurposing drugs against Sporothrix brasiliensis." PeerJ 11 (November 30, 2023): e16443. http://dx.doi.org/10.7717/peerj.16443.

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Background Sporotrichosis caused by Sporothrix brasiliensis is a globally emerging infectious disease with limited therapeutic options. Thus, we aimed to evaluate the in vitro activity of amlodipine (AML) and lufenuron (LUF) alone and their interaction with itraconazole (ITZ), the first-choice drug against S. brasiliensis. Methods Twenty clinical isolates of S. brasiliensis from two hyperendemic regions were tested through a microdilution assay to evaluate the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of AML and LUF. Checkerboard assay was performed with

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Odintsova, Tatyana, Larisa Shcherbakova, Marina Slezina, et al. "Hevein-Like Antimicrobial Peptides Wamps: Structure–Function Relationship in Antifungal Activity and Sensitization of Plant Pathogenic Fungi to Tebuconazole by WAMP-2-Derived Peptides." International Journal of Molecular Sciences 21, no. 21 (2020): 7912. http://dx.doi.org/10.3390/ijms21217912.

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Hevein-like antimicrobial peptides (AMPs) comprise a family of plant AMPs with antifungal activity, which harbor a chitin-binding site involved in interactions with chitin of fungal cell walls. However, the mode of action of hevein-like AMPs remains poorly understood. This work reports the structure–function relationship in WAMPs—hevein-like AMPs found in wheat (Triticum kiharae Dorof. et Migush.) and later in other Poaceae species. The effect of WAMP homologues differing at position 34 and the antifungal activity of peptide fragments derived from the central, N- and C-terminal regions of one

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Verma, Swapnil, and Priya Jain. "Synthesis & Pharmacological Activity of Cytotoxicity Assay of Coumarins SVCM1-SVCM7." International Journal of Medical, Pharmacy and Drug Research 7, no. 5 (2023): 01–07. http://dx.doi.org/10.22161/ijmpd.7.5.1.

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The therapeutic properties of natural and synthetic compounds against human illnesses have attracted a lot of interest. The pharmacological and biological effects of coumarins are widely exploited in medicine; they include anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antibacterial, and neuroprotective properties. Signaling pathways affecting many cellular functions may also be modulated by coumarin derivates. Whether or not a coumarin has pharmacological, biochemical, or therapeutic characteristics is dependent on the nature of the replacement surrounding th

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Aljassim, Zainab G., Haitham M. Kadhim, and Abbas S. Al-mizraqchi. "Evaluation of Antimicrobial Activity of Pleurotus ostreatus on Selected Multi-Drug Resistant Bacteria and Fungus." Sumer 2 8, CSS 2 (2023): 1–10. http://dx.doi.org/10.21931/rb/css/2023.08.02.72.

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Pleurotus ostreatus, or oyster mushroom, is a common edible wild mushroom characterized by its high nutritional values and promising diverse biological activities. It contains many bioactive components which have been found to possess several therapeutic functions. Because of the rising threat of treating serious and resistant infections, there is a developing need to discover new treatment strategies and compounds that can effectively eradicate infections. This study aims to evaluate and measure the antimicrobial activity and the minimum bactericidal concentration (MBC) and Minimum fungicidal

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Tompros, Adrianna, Mark Q. Wilber, Andy Fenton, Edward Davis Carter, and Matthew J. Gray. "Efficacy of Plant-Derived Fungicides at Inhibiting Batrachochytrium salamandrivorans Growth." Journal of Fungi 8, no. 10 (2022): 1025. http://dx.doi.org/10.3390/jof8101025.

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The emerging fungal amphibian pathogen, Batrachochytrium salamandrivorans (Bsal), is currently spreading across Europe and given its estimated invasion potential, has the capacity to decimate salamander populations worldwide. Fungicides are a promising in situ management strategy for Bsal due to their ability to treat the environment and infected individuals. However, antifungal drugs or pesticides could adversely affect the environment and non-target hosts, thus identifying safe, effective candidate fungicides for in situ treatment is needed. Here, we estimated the inhibitory fungicidal effic

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Chaudhary, Vidhi, Radha Prasanna, Vishal Gupta, Shashi B. Singh, Chitra Natarajan, and Lata Nain. "Development of microtitre plate-based assay for evaluation of fungicidal potential of cyanobacterial metabolites." Archives Of Phytopathology And Plant Protection 43, no. 14 (2010): 1435–44. http://dx.doi.org/10.1080/03235408.2010.484943.

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Brasch, J., and B. Friege. "Dicarboxylic acids affect the growth of dermatophytes in vitro." Acta Dermato-Venereologica 74, no. 5 (1994): 347–50. http://dx.doi.org/10.2340/0001555574351354.

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Azelaic acid is a dicarboxylic acid with known antimycotic activity. In this study we have used an agar dilution technique to test the effect of six other dicarboxylic acids (sebacic, undecanedioic, dodecanedioic, tridecanedioic, tetradecanedioic and hexadecanedioic acid, 10(-4)-10(-2) mol/l, pH 5.5) on in vitro growth of Trichophyton (T.) rubrum, T. mentagrophytes and Microsporum (M.) canis. Furthermore, the fungicidal activity of 10(-2) mol/l undecanedioic and sebacic acid was tested using a T. rubrum growth assay. Undecanedioic acid proved fungistatic at 10(-2) mol/l for all species and fun

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Abneuf, Mohammed A., Abiramy Krishnan, Marcelo Gonzalez Aravena, et al. "Antimicrobial activity of microfungi from maritime Antarctic soil." Czech Polar Reports 6, no. 2 (2016): 141–54. http://dx.doi.org/10.5817/cpr2016-2-13.

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The search for cold-adapted and cold-active fungi in extreme environments provides the potential for discovering new species and novel bioactive compounds. In this study, soil samples were collected from Deception Island, Wilhelmina Bay (north-west Antarctic Peninsula, Graham Land) and Yankee Bay (Greenwich Island), maritime Antarctica, for the isolation of soil fungi and determination of their antimicrobial activity. The soil-plate method, agar block, disc diffusion and broth micro-dilution assays were applied to characterize the thermal classes and antimicrobial activity of the isolated fung

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Zaki, Shimaa A., Salama A. Ouf, Fawziah M. Albarakaty, Marian M. Habeb, Aly A. Aly, and Kamel A. Abd-Elsalam. "Trichoderma harzianum-Mediated ZnO Nanoparticles: A Green Tool for Controlling Soil-Borne Pathogens in Cotton." Journal of Fungi 7, no. 11 (2021): 952. http://dx.doi.org/10.3390/jof7110952.

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ZnO-based nanomaterials have high antifungal effects, such as inhibition of growth and reproduction of some pathogenic fungi, such as Fusarium sp., Rhizoctonia solani and Macrophomina phaseolina. Therefore, we report the extracellular synthesis of ZnONPs using a potential fungal antagonist (Trichoderma harzianum). ZnONPs were then characterized for their size, shape, charge and composition by visual analysis, UV–visible spectrometry, X-ray diffraction (XRD), Zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDX). Th

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Anderson, S. J., H. E. Simmons, and G. P. Munkvold. "Real-Time PCR Assay for Detection of Sphacelotheca reiliana Infection in Maize (Zea mays) Seedlings and Evaluation of Seed Treatment Efficacy." Plant Disease 99, no. 12 (2015): 1847–52. http://dx.doi.org/10.1094/pdis-07-14-0776-re.

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Head smut of maize, caused by the fungus Sphacelotheca reiliana, is an economically important disease in all major maize-producing countries. Although seed treatments are commonly used for management purposes, evaluating these treatments for efficacy is both time consuming and inefficient. Therefore, in order to improve the capacity for evaluating seed treatment fungicides, we developed a real-time PCR-based seedling assay for S. reiliana infection. We optimized growth chamber conditions and inoculation methods to achieve infection incidence of 60 to 80% in inoculated, nontreated controls. The

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Khalifa, Hazim O., Hidetaka Majima, Akira Watanabe, and Katsuhiko Kamei. "In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata." Journal of Fungi 7, no. 2 (2021): 108. http://dx.doi.org/10.3390/jof7020108.

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This study was designed to analyze the interaction of 21 antifungal combinations consisting of seven major antifungal agents against 11 echinocandin- susceptible and six-resistant C. glabrata isolates. The combinations were divided into five major groups and were evaluated by checkerboard, disc diffusion, and time-killing assays. Synergy based on the fractional inhibitory concentration index of ≤0.50 was observed in 17.65–29.41% of the cases for caspofungin combinations with azoles or amphotericin B. Amphotericin B combination with azoles induced synergistic interaction in a range of 11.76–29.

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Znini, Mohamed, Gregory Cristofari, Lhou Majidi, et al. "Antifungal Activity of Essential Oil from Asteriscus graveolens against Postharvest Phytopathogenic Fungi in Apples." Natural Product Communications 6, no. 11 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601147.

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The essential oils of the aerial parts of Asteriscus graveolens have been studied using GC and GC-MS. Twenty-eight compounds were identified in the essential oil amounting to 94.9% of the total oil. The aerial part oils showed similar chromatographic profiles and were characterized by having a high content of oxygenated sesquiterpenes with 6-oxocyclonerolidol (66.7% ±5.5) and 6-hydroxycyclonerolidol (8.8% ±1.2) as the major components. The antifungal effect of the essential oil from A. graveolens leaves was evaluated in vitro against three phytopathogenic fungi of apples ( Alternaria sp., Peni

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Bartholomäus, Anika, Stefan Mittler, Bernward Märländer, and Mark Varrelmann. "Control of Rhizoctonia solani in Sugar Beet and Effect of Fungicide Application and Plant Cultivar on Inoculum Potential in the Soil." Plant Disease 101, no. 6 (2017): 941–47. http://dx.doi.org/10.1094/pdis-09-16-1221-re.

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Rhizoctonia solani (AG 2-2 IIIB) is the causal agent of Rhizoctonia root and crown rot, a disease that causes severe economic problems in sugar beet growing areas worldwide. In the United States, azoxystrobin is the most important active ingredient for fungicidal control of R. solani in sugar beet, showing efficacy superior to other substances. First reports on resistance development in R. solani, however, underline the importance of a careful fungicide resistance management. For this reason, the efficacy of a new fungicide mixture of azoxystrobin and difenoconazole was compared with a fungici

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Butts, Arielle, Louis DiDone, Kristy Koselny, et al. "A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis." Eukaryotic Cell 12, no. 2 (2012): 278–87. http://dx.doi.org/10.1128/ec.00314-12.

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ABSTRACT New, more accessible therapies for cryptococcosis represent an unmet clinical need of global importance. We took a repurposing approach to identify previously developed drugs with fungicidal activity toward Cryptococcus neoformans , using a high-throughput screening assay designed to detect drugs that directly kill fungi. From a set of 1,120 off-patent medications and bioactive molecules, we identified 31 drugs/molecules with fungicidal activity, including 15 drugs for which direct antifungal activity had not previously been reported. A significant portion of the drugs are orally bioa

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Ruangwong, On-Uma, Kaewalin Kunasakdakul, Sompong Chankaew, Kitsada Pitija, and Anurag Sunpapao. "A Rhizobacterium, Streptomyces albulus Z1-04-02, Displays Antifungal Activity against Sclerotium Rot in Mungbean." Plants 11, no. 19 (2022): 2607. http://dx.doi.org/10.3390/plants11192607.

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Sclerotium rot causes damping-off and stem rot in seedlings and mature mungbeans, which negatively impacts cultivation. The use of a rhizobacterium to control soil-borne diseases is an alternative method to the excess use of synthetic fungicides; therefore, this study aims to screen rhizosphere actinobacteria with fungicidal activities against Sclerotium rolfsii, the pathogen that causes sclerotium rot in mungbeans. Primary screening showed that the Streptomyces sp. isolate Z1-04-02 displayed the highest effectiveness against S. rolfsii in dual culture plates, with a percentage inhibition of 7

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Cho, Yoon, Jeffrey S. Turner, Nhu-Nguyen Dinh, and Robert I. Lehrer. "Activity of Protegrins against Yeast-PhaseCandida albicans." Infection and Immunity 66, no. 6 (1998): 2486–93. http://dx.doi.org/10.1128/iai.66.6.2486-2493.1998.

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ABSTRACT We used a two-stage radial diffusion assay to perform a structure-activity study of the antifungal effects of protegrin-1 (PG-1) on yeast-phase Candida albicans. While doing so, we computed MICs from the radial diffusion assay data by three methods and compared the respective values with results from colony count and broth microdilution assays. This allowed us to identify several technical modifications that improved the sensitivity and accuracy of radial diffusion assays. We found that both PG-1 and enantiomeric PG-1 (composed exclusively of d-amino acids) were potently fungicidal fo

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Ghannoum, M., N. Isham, A. Verma, S. Plaum, A. Fleischer, and B. Hardas. "In VitroAntifungal Activity of Naftifine Hydrochloride against Dermatophytes." Antimicrobial Agents and Chemotherapy 57, no. 9 (2013): 4369–72. http://dx.doi.org/10.1128/aac.01084-13.

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ABSTRACTThe incidence of superficial dermatophytoses is high in developed countries, and there remains a need for effective topical antifungals. In this study, we evaluated thein vitroantifungal activity of naftifine hydrochloride, the active ingredient in naftifine hydrochloride cream and gel 1% and 2%, against dermatophytes. The MICs and minimum fungicidal concentrations (MFCs) of naftifine hydrochloride against 350 clinical strains, includingTrichophyton rubrum,T. mentagrophytes,T. tonsurans,Epidermophyton floccosum, andMicrosporum canis, were determined using the CLSI methodology. Subsets

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Teixeira-Santos, Rita, Elisabete Ricardo, Susana Gomes Guerreiro, Sofia Costa-de-Oliveira, Acácio Gonçalves Rodrigues, and Cidália Pina-Vaz. "New Insights Regarding Yeast Survival following Exposure to Liposomal Amphotericin B." Antimicrobial Agents and Chemotherapy 59, no. 10 (2015): 6181–87. http://dx.doi.org/10.1128/aac.00575-15.

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ABSTRACTIn vitroresistance to amphotericin B is an extremely rare event among pathogenic yeasts. However,in vivoresponse is sometimes reduced, resulting in an unfavorable outcome. Such adverse outcomes might be related to subfungicidal plasma concentrations. We aimed to clarify the mechanisms of liposomal amphotericin B (AMB-L; AmBisome)-induced lesions and the mechanisms responsible for yeast cell recovery following exposure at plasma concentrations. The physiological statuses developing following exposure to AMB-L at simulated plasma concentrations (20 to 0.1 mg/liter) and at a constant conc

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Teixeira, Bráulio de Almeida, Helivaldo Diógenes da Silva Souza, Gabriela Fehn Fiss, et al. "Fungicidal and antibiofilm activities of 2-Bromo-N-Phenylacetamide Against Fluconazole-Resistant Candida spp.: a promising antifungal agent." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 12 (2023): 24080–101. http://dx.doi.org/10.55905/oelv21n12-035.

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Purpose: Amides are proven to possess antimicrobial properties against both fungi and bacteria. The synthetic amide 2-bromo-N-phenylacetamide exhibits antifungal activity according to scientific literature, however, data remains scarce. Given the clinical and epidemiological importance as well as the increasing antifungal resistance in Candida spp., here we aimed to better explore the antifungal potential of 2-bromo-N-phenylacetamide against fluconazole-resistant Candida albicans, Candida glabrata, Candida parapsilosis and for the first time, against Candida tropicalis as well. Methods: Minimu

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Sabir, Mohammed N., Kawkab Y. Saour, and Shwan Rachid. "In vitro cytotoxic and antimicrobial effects of a novel peroxysesquiterpene glucoside from the rhizomes of Cyperus rotundus L (Cyperaceae)." Tropical Journal of Pharmaceutical Research 19, no. 2 (2020): 331–39. http://dx.doi.org/10.4314/tjpr.v19i2.16.

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Purpose: To study the antimicrobial and cytotoxic potential of a novel 3,9-peroxsesquiterpene-15-Oglucoside from Cyperus rotundus rhizomes, against HeLa cell line and selected strains of microorganisms. Methods: The rhizomes were macerated with methanol and fractionated with n-hexane, chloroform, ethyl acetate and butanol. High-performance liquid chromatography (HPLC) was performed together with chemical analysis of the fractions. The 3,9-peroxysesquiterpene-15-O-glucoside was purified through column chromatography of the ethyl acetate fraction, and its purity was determined via reversep

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Cruz-Rodríguez, Rosa Isela, Abumalé Cruz-Salomón, Nancy Ruiz-Lau, José Iván Pérez-Villatoro, Hector Armando Esquinca-Avilés, and Rocío Meza-Gordillo. "Potential Application of Crotalaria longirostrata Branch Extract to Reduce the Severity of Disease Caused by Fusarium." Agronomy 10, no. 4 (2020): 524. http://dx.doi.org/10.3390/agronomy10040524.

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Fusarium are considered as the major plant pathogen fungi, that cause the majority of soil-borne diseases to more than 100 plant species in the world, including maize. Thus, there are emerging demands of biocontrol reagents, and Crotalaria longirostrata showed fungicidal activity. The C. longirostrata branch extract was phytochemically characterized and evaluated for efficacy for the control of Fusarium wilt in maize. The application of the extract reduced the percentage of disease incidence significantly caused by Fusarium verticillioides from 70.4% to 40.12% as compared to non-treated plants

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