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1

Chang, Meng-Yang, and Hang-Yi Tai. "Synthesis of Furo[2,3-c]pyridine." HETEROCYCLES 83, no. 8 (2011): 1889. http://dx.doi.org/10.3987/com-11-12248.

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2

Shiotani, Shunsaku. "Furopyridines.XIV. Synthesis of 2-aminoalkyl derivatives of furo[2,3-b]-, furo[3,2-b], furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 30, no. 4 (1993): 1035–39. http://dx.doi.org/10.1002/jhet.5570300432.

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3

Vrábel, Viktor, Ľubomír Švorc, Ivana Bradiaková, Jozef Kožíšek, and Alžbeta Krutošíková. "2-[3-(Trifluoromethyl)phenyl]furo[2,3-c]pyridine." Acta Crystallographica Section E Structure Reports Online 63, no. 12 (2007): o4516. http://dx.doi.org/10.1107/s1600536807054062.

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4

Chang, Meng-Yang, and Hang-Yi Tai. "ChemInform Abstract: Synthesis of Furo[2,3-c]pyridine." ChemInform 42, no. 48 (2011): no. http://dx.doi.org/10.1002/chin.201148163.

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5

Shiotani, Shunsaku, Hiroyuki Morita, Toshimasa Ishida, and Yasuko In. "Furopyridines.IX. Syntheses and properties of 3-ethoxy derivatives of furo[2,3-b]-, furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 25, no. 4 (1988): 1205–13. http://dx.doi.org/10.1002/jhet.5570250431.

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6

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines.XI.13C NMR Spectra of 2- or 3-Substituted Furo[2,3-b]-, Furo[3,2-b]-, Furo[2,3-c]- and Furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 28, no. 6 (1991): 1469–80. http://dx.doi.org/10.1002/jhet.5570280601.

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7

Chartoire, Anthony, Corinne Comoy, and Yves Fort. "Toolbox for Regioselective Lithiations of Furo[2,3-c]pyridine." Journal of Organic Chemistry 75, no. 7 (2010): 2227–35. http://dx.doi.org/10.1021/jo902666w.

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8

Al‐Refai, Mahmoud, Mohammad Ibrahim, Abdullah Al‐Fawwaz, and Armin Geyer. "Synthesis and characterization of new 4-aryl-2-(2-oxopropoxy)-6-(2,5-dichlorothiophene)nicotinonitrile and their furo[2,3-b]pyridine derivatives: Assessment of antioxidant and biological activity." European Journal of Chemistry 9, no. 4 (2018): 375–81. http://dx.doi.org/10.5155/eurjchem.9.4.375-381.1792.

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A new series of furo[2,3-b]pyridine derivatives bearing aryl substituents were synthesized in two steps, where, the cyano-(2H)-pyridones (1a-l) were converted to the corresponding nicotinonitriles (2a-l), followed by the Thorpe-Ziegler ring cyclization to the furo[2,3-b]pyridine derivatives (3a-l). All new compounds were characterized by 1D-NMR experiments (1H and 13C) and 2D-NMR experiments (COSY, HMBC and HSQC), as well as ESI-MS and HR-ESI-MS data. The new compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) free radical assay. The highest
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9

SHIOTANI, S. "ChemInform Abstract: Furopyridines. Part 14. Synthesis of 2-Aminoalkyl Derivatives of Furo( 2,3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 25, no. 7 (2010): no. http://dx.doi.org/10.1002/chin.199407176.

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10

Chang, Meng-Yang, and Hang-Yi Tai. "Synthesis of Furo[2,3-b]pyridine." HETEROCYCLES 83, no. 10 (2011): 2373. http://dx.doi.org/10.3987/com-11-12305.

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11

Molina, P., P. M. Fresneda, and F. Hurtado. "An Efficient Iminophosphorane-Mediated Synthesis of Thieno[3,2-c]pyridine, Thieno[2,3-c]pyridine and Furo[3,2-c]-pyridine Derivatives." Synthesis 1987, no. 01 (1987): 45–48. http://dx.doi.org/10.1055/s-1987-27837.

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12

Shiotani, Shunsaku, and Katsunori Taniguchi. "Furopyridines.XXIII. Synthesis and reactions of chloropyridine derivatives of furo[2,3-b]-, -[2,3-c]- and -[3,2-c]pyridine." Journal of Heterocyclic Chemistry 34, no. 3 (1997): 925–29. http://dx.doi.org/10.1002/jhet.5570340333.

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13

Yamaguchi, Sciji, Hideo Saitoh, Masahide Kurosaki, Hajime Yokoyama, Yoshiro Hirai, and Shunsaku Shiotani. "Furopyridines.XXVI. Reactions of cyanopyridine derivatives of furo[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine." Journal of Heterocyclic Chemistry 36, no. 1 (1999): 1–9. http://dx.doi.org/10.1002/jhet.5570360101.

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14

Shiotani, Shunsaku, Katsunori Taniguchi, Toshimasa Ishida, and Yasuko In. "Furopyridines.XIX. Reaction of furo[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine with acetic anhydride." Journal of Heterocyclic Chemistry 33, no. 3 (1996): 647–54. http://dx.doi.org/10.1002/jhet.5570330321.

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15

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines.XII. Reaction of 3-bromo, 2-phenylthio and 2-phenylthio-3-bromo derivatives of furo[2,3-b]-, furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine with several alkyllithiums." Journal of Heterocyclic Chemistry 29, no. 2 (1992): 413–22. http://dx.doi.org/10.1002/jhet.5570290221.

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16

Hung, Joy M., Homayon J. Arabshahi, Euphemia Leung, Jóhannes Reynisson, and David Barker. "Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives." European Journal of Medicinal Chemistry 86 (October 2014): 420–37. http://dx.doi.org/10.1016/j.ejmech.2014.09.001.

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17

Chang, Meng-Yang, and Hang-Yi Tai. "ChemInform Abstract: Synthesis of Furo[2,3-b]pyridine." ChemInform 43, no. 7 (2012): no. http://dx.doi.org/10.1002/chin.201207143.

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18

Vadla, Balakishan, and Sailu Betala. "Novel 1,2,3-Triazole-functionalized pyrido[3',2':4,5]furo[3,2-d]pyrimidin- 4(3H)-one Derivatives: Synthesis, Anticancer Activity, CoMFA and CoMSIA Studies." Letters in Organic Chemistry 17, no. 12 (2020): 969–78. http://dx.doi.org/10.2174/1570178617666200319124017.

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A series of novel triazole functionalized pyrido [3',2':4,5] furo[3,2-d] pyrimidin-4 (3H)-one derivatives 7a-p were prepared from ethyl furo[2,3-b]pyridine-2-carboxylate 3 on reaction with ammonia to afford furo[2,3-b]pyridine-2-carboxamide 4. This compound, on reaction with triethyl orthoformate TEOF, gave compound 5. Compound 5 on propargylation, followed by a reaction with substituted aryl azides under Sharpless reaction conditions, furnished triazole tagged pyrido [3',2':4,5]furo[3,2-d] pyrimidin-4(3H)-one derivatives. All the products 7a-p were screened against four human cancer cell line
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19

Morita, Hiroyuki, and Shunsaku Shiotani. "Furopyridines. VII. Preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 24, no. 2 (1987): 373–76. http://dx.doi.org/10.1002/jhet.5570240216.

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20

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines. X. Synthesis of tricyclic heterocycles, furo[2,3-b:4,5-c']-, furo[3,2-b:4,5-c']-, furo[2,3-c:4,5-c']- and furo[3,2-c:4,5-c']dipyridine." Journal of Heterocyclic Chemistry 27, no. 3 (1990): 637–42. http://dx.doi.org/10.1002/jhet.5570270330.

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21

Tolkunov, S. V., A. I. Khizhan, S. I. Simonova, N. S. emenov, and S. N. Lyashchuk. "Condensed pyridine bases synthesis of some benzo[b]furo[2,3-c]-, benzo[b]- thieno[2,3-c]-, and benzo[b]selenopheno[2,3-c]-quinolines." Chemistry of Heterocyclic Compounds 30, no. 3 (1994): 283–88. http://dx.doi.org/10.1007/bf01165692.

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22

Bencková, Mária, and Alžbeta Krutošíková. "5-Aminofuro[3,2-c]pyridinium Tosylates and Substituted Furo[3,2-c]pyridine N-Oxides: Synthesis and Reactions." Collection of Czechoslovak Chemical Communications 64, no. 3 (1999): 539–47. http://dx.doi.org/10.1135/cccc19990539.

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5-Aminofuro[3,2-c]pyridinium tosylates 2a-2c were synthesized by direct N-amination of furo[3,2-c]pyridines 1a-1c with O-(4-methylbenzenesulfonyl)hydroxylamine in dichloromethane. Zwitterionic furo[3,2-c]pyridinium N-imides 3a-3c generated from 2a-2c and anhydrous potassium carbonate in N,N-dimethylformamide afforded by 1,3-dipolar cycloaddition reactions with dimethyl butynedioate or ethyl propiolate the corresponding furo[3,2-c]pyrazolo[1,5-a]pyridinecarboxylic esters 4a-4c and 5a-5c. Furo[3,2-c]pyridine N-oxides 6a-6c and their benzo derivative 6d were synthesized by reaction of 1 with 3-ch
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23

SHIOTANI, S., and H. MORITA. "ChemInform Abstract: Furopyridines. Part 11. 13C NMR Spectra of 2- or 3-Substituted Furo(2, 3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 23, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199213045.

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24

Racha, Hanumandlu, Balakishan Vadla, Kavitha Peddolla, and Sailu Betala. "Synthesis and Anticancer Activity of Novel Hetero Ring Fused Pyridine Amide Derivatives." Asian Journal of Chemistry 31, no. 11 (2019): 2485–91. http://dx.doi.org/10.14233/ajchem.2019.22150.

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A series of novel hetero ring fused pyridine amide derivatives were prepared starting from ethyl furo[2,3-b]pyridine-2-carboxylate (3) on reaction with ammonia to afford furo[2,3-b]pyridine-2-carboxamide (4), compound 4 on reaction with trifluoroacetic acid to give compound 5, which on reaction with bromoethyl acetate followed by hydrazine hydrate to give compound 7. Compound 7 when reacted with different substituted aromatic aldehydes to give Schiff base compounds (8a-l). Similarly, compound 6a when reacted with diverse substituted aliphatic amines to give amide derivatives (9a-h). All the sy
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25

Sirakanyan, S. N., E. K. Hakobyan, and A. A. Hovakimyan. "Synthesis of New Furo[2,3-b]pyridine and Furo[3,2-d]pyrimidine Derivatives." Russian Journal of Organic Chemistry 55, no. 9 (2019): 1344–50. http://dx.doi.org/10.1134/s1070428019090136.

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26

Laxmi, Dandamudi Sri, Suryadevara V. Vardhini, Venkata R. Guttikonda, Mandava V. B. Rao, and Manojit Pal. "Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 8 (2020): 932–40. http://dx.doi.org/10.2174/1871520620666200311102304.

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Background: Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties, including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives, some of them are complex. Objective: The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. Methods: We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond-forming reaction
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27

Canonne, P., and M. Belley. "Étude de l'action des organomagnésiens sur les dérivés carboxyliques de la pyridine." Canadian Journal of Chemistry 65, no. 8 (1987): 1885–90. http://dx.doi.org/10.1139/v87-316.

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Reactions of Grignard reagents with pyridinecarboxylic esters 1, 2, pyridine-2-carboxylic acid (3), and 2,3-pyridinedicarboxylic acid anhydride (5) show regioselectivity at the carbonyl in position 2. This is exemplified by an efficient synthesis of 7,7-dialkylated-7H-furo[3,4-b]-substituted pyridin-5-ones.
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28

SHIOTANI, S., and H. MORITA. "ChemInform Abstract: Furopyridines. Part 12. Reaction of 3-Bromo, 2-Phenylthio and 2- Phenylthio-3-bromo Derivatives of Furo(2,3-b)-, Furo(3,2-b)-, Furo(2,3- c)- and Furo(3,2-c)pyridine with Several Alkyllithiums." ChemInform 23, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199239201.

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29

Shiotani, Shunsaku, and Katsunori Tanigochi. "Furopyridines.XXII. Elaboration of theC-substituentsalphato the heteronitrogen atom of furo[2,3-b] -, -[3,2-b] -, -[2,3-c]- and -[3,2-c]pyridine." Journal of Heterocyclic Chemistry 34, no. 3 (1997): 901–7. http://dx.doi.org/10.1002/jhet.5570340329.

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30

Koreňová, Anna, Alžbeta Krutošíková, Jaroslav Kováč, and Stanislav Celec. "Synthesis and reactions of furo[3,2-c]pyridine derivatives." Collection of Czechoslovak Chemical Communications 52, no. 1 (1987): 192–98. http://dx.doi.org/10.1135/cccc19870192.

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The synthesis of a new type of condensed heterocycle pyrido[3',4':4,5]furo[3,2-b]indole (V) and 1,2,4-triazolo[4'',3'':1',2']pyrido[3',4':4,5]furo[3,2-b]indoles (IX) is described and the substitution nucleophilic reaction with 2-(2-nitrophenyl)-4-chlorofuro[3,2-c]pyridine (X) is presented.
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31

Sonawane, Amol D., Dinesh R. Garud, Taro Udagawa, Yasuhiro Kubota, and Mamoru Koketsu. "Synthesis of thieno[2,3-c]acridine and furo[2,3-c]acridine derivatives via an iodocyclization reaction and their fluorescence properties and DFT mechanistic studies." New Journal of Chemistry 42, no. 18 (2018): 15315–24. http://dx.doi.org/10.1039/c8nj03511c.

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In this paper, we report the novel synthesis of thieno[2,3-c]acridine and furo[2,3-c]acridine derivatives via intramolecular iodocyclization reaction. The thieno[2,3-c]acridine derivatives exhibited blue fluorescence in hexane.
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32

Yamaguchi, Seiji, Masahide Kurosaki, Keiko Orito, Hajime Yokayama, Yoshiro Hirai, and Shunsaku Shiotani. "Furopyridines.XXVII. Reactions of 2-methyl and 2-cyano derivatives of furo[2,3-b]-, -[3,2-b]-, - [2,3-c]- and -[3,2-c]pyridine." Journal of Heterocyclic Chemistry 35, no. 6 (1998): 1237–47. http://dx.doi.org/10.1002/jhet.5570350601.

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33

Yamaguchi, Seiji, Kazuaki Awajima, Yoshiro Hirai, Hajime Yokoyama, and Shunsaku Shiotani. "Furopyridines.XXVIII. Reactions of 3-bromo derivatives of furo[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine and theirN-oxides." Journal of Heterocyclic Chemistry 35, no. 6 (1998): 1249–55. http://dx.doi.org/10.1002/jhet.5570350602.

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34

SHIOTANI, S., K. TANIGUCHI, T. ISHIDA, and Y. IN. "ChemInform Abstract: Furopyridines. Part 19. Reaction of Furo(2,3-b)-, -(3,2-b)-, -(2,3-c)-, and -(3,2-c)pyridine with Acetic Anhydride." ChemInform 27, no. 50 (2010): no. http://dx.doi.org/10.1002/chin.199650155.

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35

SHIOTANI, S., and K. TANIGUCHI. "ChemInform Abstract: Furopyridines. Part 23. Synthesis and Reactions of Chloropyridine Derivatives of Furo(2,3-b)-, -(2,3-c)-, and -(3,2-c)pyridine." ChemInform 28, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199745160.

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36

Yamaguchi, Seiji, Hideo Saitoh, Masahide Kurosaki, Hajime Yokoyama, Yoshiro Hirai, and Shunsaku Shiotani. "ChemInform Abstract: Furopyridines. Part 26. Reactions of Cyanopyridine Derivatives of Furo[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine." ChemInform 30, no. 33 (2010): no. http://dx.doi.org/10.1002/chin.199933163.

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37

Janeba, Zlatko, Noha Maklad, and Morris J. Robins. "Synthesis of 6-(alkoxymethyl)- and 6-(alkylsulfanylmethyl)furo[2,3-d]pyrimidin-2(3H)-one analogues." Canadian Journal of Chemistry 84, no. 4 (2006): 561–68. http://dx.doi.org/10.1139/v06-042.

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Treatment of 6-(hydroxymethyl)furo[2,3-d]pyrimidin-2(3H)-one (2) with 1-iodoalkanes and potassium carbonate resulted in predominant formation of N3 (and minor amounts of O2) alkylated regioisomers. Treatment of the 3-alkyl products (3) with thionyl chloride gave highly reactive 6-chloromethyl intermediates (5). Direct solvolysis of 5 in alcohol solutions (~50 °C) produced 3-alkyl-6-(alkoxymethyl)furopyrimidin-2(3H)-ones (6), whereas extensive decomposition of 5 occurred with added base promoters. Sonication of 5 with sodium thioacetate in acetonitrile gave the air-stable 6-(alkylsulfanylmethyl
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38

Choi, Woo-Baeg, Ioannis N. Houpis, Hywyn R. O. Churchill, et al. "A practical synthesis of the 5-chloromethyl-furo[2,3-b]pyridine pharmacophore." Tetrahedron Letters 36, no. 26 (1995): 4571–74. http://dx.doi.org/10.1016/0040-4039(95)00850-c.

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39

Hrašna, Martin, Eva Ürgeová, and Alžbeta Krutošíková. "Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting Compounds." Nova Biotechnologica et Chimica 11, no. 1 (2012): 73–85. http://dx.doi.org/10.2478/v10296-012-0008-x.

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Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting CompoundsSome [3,2-c]pyridine derivatives were synthesized. 3-(Furan-2-yl)propenoic acid (1a) was prepared from furan-2-carbaldehyde under the Perkin's conditions. Obtained acid was converted to the corresponding azide3, which in turn was cyclized to give furo[3,2-c]pyridin-4(5H)-one (4a). The reaction of pyridone4awith phosphorus oxychloride rendered the chloroderivative7a, which was treated in the condition of Suzuki coupling reaction with boronic acid to give 4-phenylfuro[3,
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40

TOLKUNOV, S. V., A. I. KHIZHAN, S. I. SIMONOVA, N. S. SEMENOV, and S. N. LYASHCHUK. "ChemInform Abstract: Condensed Pyridine Bases. Synthesis of Some Derivatives of Benzo(b) furo(2,3-c)-, Benzo(b)thieno(2,3-c)- and Benzo(b)selenopheno(2,3-c) quinolines." ChemInform 26, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199512194.

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41

Tolkunov, S. V., M. N. Kal'nitskii, S. N. Lyashchuk, S. Yu Suikov, M. Yu ubritskii, and V. I. Dulenko. "Condensed pyridine bases. Electrophilic substitution in 1,7-dimethyl-3(2H)-benzo[b]furo[2,3-c]pyridone." Chemistry of Heterocyclic Compounds 32, no. 4 (1996): 466–72. http://dx.doi.org/10.1007/bf01165914.

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42

Dulenko, V. I., and V. N. Voshchula. "Furo[2,3-c]pyrylium ? A new heteroaromatic system." Chemistry of Heterocyclic Compounds 22, no. 6 (1986): 677. http://dx.doi.org/10.1007/bf00575255.

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43

Nalbandyan, G. K., E. G. Paronikyan, A. P. Mkrtchyan, A. S. Noravyan, and S. A. Vartanyan. "Synthesis of furo[2,3-c]pyran and some properties of 2-amino derivatives of furo- and pyrrolo[2,3-c]pyrans." Chemistry of Heterocyclic Compounds 27, no. 3 (1991): 256–58. http://dx.doi.org/10.1007/bf00474223.

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44

Yan, Zhimin, Yanping Wang, Junqiao Ding, Yue Wang, and Lixiang Wang. "Methoxyl modification in furo[3,2-c]pyridine-based iridium complexes towards highly efficient green- and orange-emitting electrophosphorescent devices." Journal of Materials Chemistry C 5, no. 46 (2017): 12221–27. http://dx.doi.org/10.1039/c7tc04269h.

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45

Shiotani, Shunsaku, and Katsunori Taniguchi. "Furopyridines.XXI. Synthesis of cyano derivatives of furo-[2,3-b]-, -[2,3-c]- and -[3,2-c]pyridine and their conversion to derivatives having another carbon-substituent." Journal of Heterocyclic Chemistry 34, no. 2 (1997): 493–99. http://dx.doi.org/10.1002/jhet.5570340223.

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46

Morita, Hiroyuki, and Shunsaku Shiotani. "Furopyridines. V. A simple synthesis of furo[2,3-c]pyridine and its 2-and 3-methyl derivatives." Journal of Heterocyclic Chemistry 23, no. 2 (1986): 549–52. http://dx.doi.org/10.1002/jhet.5570230248.

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47

Buckmelter, Alex J., Li Ren, Ellen R. Laird, et al. "The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors." Bioorganic & Medicinal Chemistry Letters 21, no. 4 (2011): 1248–52. http://dx.doi.org/10.1016/j.bmcl.2010.12.039.

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Yan, Zhimin, Yanping Wang, Jiaxiu Wang, Yue Wang, Junqiao Ding, and Lixiang Wang. "A novel furo[3,2-c]pyridine-based iridium complex for high-performance organic light-emitting diodes with over 30% external quantum efficiency." J. Mater. Chem. C 5, no. 39 (2017): 10122–25. http://dx.doi.org/10.1039/c7tc03937a.

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Arnoldi, Anna, Giovanna Bregante, Patrizia Caldirola, Lucio Merlini, and Bruno Tamburini. "A New synthesis of 4,5,6,7-tetrahydrofuro[2,3-c]pyridines and furo[2,3-c]pyrrolidines." Journal of Heterocyclic Chemistry 27, no. 5 (1990): 1169–71. http://dx.doi.org/10.1002/jhet.5570270501.

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Fumagalli, Fernando, Shaiani Maria Gil de Melo, Camila Maríngolo Ribeiro, Mariana Cristina Solcia, Fernando Rogério Pavan, and Flavio da Silva Emery. "Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis." Bioorganic & Medicinal Chemistry Letters 29, no. 8 (2019): 974–77. http://dx.doi.org/10.1016/j.bmcl.2019.02.019.

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