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Journal articles on the topic 'Furo[2'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sleziak, Róbert, Slávka Balážiová, and Alžbeta Krutošíková. "Reactions of Furo[2,3-b]pyrrole and Furo[3,2-b]pyrrole-Type Aldehydes." Collection of Czechoslovak Chemical Communications 64, no. 7 (1999): 1135–46. http://dx.doi.org/10.1135/cccc19991135.

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The synthesis of methyl 2-formyl-6-(methoxymethyl)furo[2,3-b]pyrrole-5-carboxylate (1d) is described. The reactions of methyl 2-formylfuro[2,3-b]pyrrole-5-carboxylates 1a-1d with malononitrile afforded methyl 2-(2,2-dicyanovinyl)furo[2,3-b]pyrrole-5-carboxylates 3a-3d, with methyl cyanoacetate methyl 2-[2-cyano-2-(methoxycarbonyl)vinyl]furo[2,3-b]pyrrole-5-carboxylates 4a-4d and with 2-furylacetonitrile methyl 2-[2-cyano-2-(2-furyl)vinyl]furo[2,3-b]pyrrole-5-carboxylates 5a-5d. Compounds 1b-1d and methyl azidoacetate gave the appropriate vinylazides 6b-6d, which were used for preparation of su

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2

Zemanová, Ivana, and Renata Gašparová. "SYNTHESIS AND REACTIONS OF NEW DERIVATIVES OF FURO[3,2-b]PYRROLE." Nova Biotechnologica et Chimica 12, no. 2 (2013): 100–107. http://dx.doi.org/10.2478/nbec-2013-0012.

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Abstract Synthesis of methyl 4H-furo[3,2-b]pyrrole-5-carboxylate is taken place in two step synthesis. Vilsmeier-Haack reaction of 4H-furo[3,2-b]pyrrole-5-carboxylate 1 led to methyl 2-formyl-4H-furo[3,2- b]pyrrole-5-carboxylate 4, which served as starting compound for synthesis of furo[3,2-b]pyrrole-2- aldoxime 5 and methyl 2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4H-furo[3,2-b]pyrrole-5- carboxylate 7. The hydrazinolysis of 1 was prepared by carbohydrazide 2, which subsequently reacted with aldehydes to form of derivatives 3. Pyrazole derivatives 11 were prepared by the reaction

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3

El-Shahawi, Manal M., and Ahmed K. El-Ziaty. "Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives." Journal of Chemistry 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/5610707.

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2-Amino-4,5-diphenylfuran-3-carbonitrile 1 was utilized as building block for the construction of new furo[2,3-d]pyrimidin-4(3H)-one derivative 2 and 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 via treatment with acetic anhydride and benzoyl chloride, respectively. The 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 was transformed into novel furo[2,3-d]pyrimidin-4(3H)-ones 4–8, tetrazolylfuran derivative 10, and furo[3,2-d]imadazolone derivative 11 via reaction with various nitrogen nucleophiles. The structure features of the synthesized compounds were established from their spectral and elemen

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4

Abu-Hashem, Ameen. "Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity." Molecules 23, no. 11 (2018): 2793. http://dx.doi.org/10.3390/molecules23112793.

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Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-o

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5

Janeba, Zlatko, Noha Maklad, and Morris J. Robins. "Synthesis of 6-(alkoxymethyl)- and 6-(alkylsulfanylmethyl)furo[2,3-d]pyrimidin-2(3H)-one analogues." Canadian Journal of Chemistry 84, no. 4 (2006): 561–68. http://dx.doi.org/10.1139/v06-042.

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Treatment of 6-(hydroxymethyl)furo[2,3-d]pyrimidin-2(3H)-one (2) with 1-iodoalkanes and potassium carbonate resulted in predominant formation of N3 (and minor amounts of O2) alkylated regioisomers. Treatment of the 3-alkyl products (3) with thionyl chloride gave highly reactive 6-chloromethyl intermediates (5). Direct solvolysis of 5 in alcohol solutions (~50 °C) produced 3-alkyl-6-(alkoxymethyl)furopyrimidin-2(3H)-ones (6), whereas extensive decomposition of 5 occurred with added base promoters. Sonication of 5 with sodium thioacetate in acetonitrile gave the air-stable 6-(alkylsulfanylmethyl

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6

A.AlOmari, Nohad, Adnan O. Omar, and Iklas M. Taher. "Preliminary Cytotoxic Study of Some Novel Furo-2-quinolone Compounds." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 32–38. http://dx.doi.org/10.31351/vol18isssuppl.pp32-38.

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In this research, new series of Furo-2-quinolone [FQ] compounds have been synthesized. These novel [FQ] compounds were prepared from coumarin derivatives (Furocoumarins: psoralen and isopsoralen).Identifications of these FQ compounds were performed by using infrared spectrum (I.R), Ultraviolet spectrum (U.V) and Nuclear Magnetic Resonance spectrum (H1-NMR) besides some physical data. The cytotoxic screening involves ;using HEP-2 cell line which gave differential responses against tested compounds : 4,6 Dimethyl furo[2, 3-g] coumarin (C1), 1-(2`, 4`, Dimethoxy benzylideneimino)-2,6-dimethyl Fur

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7

Shiotani, Shunsaku. "Furopyridines.XIV. Synthesis of 2-aminoalkyl derivatives of furo[2,3-b]-, furo[3,2-b], furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 30, no. 4 (1993): 1035–39. http://dx.doi.org/10.1002/jhet.5570300432.

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8

Cho, Young K., Michael E. Smith, and Ralph Norgren. "Low-dose furosemide modulates taste responses in the nucleus of the solitary tract of the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 4 (2004): R706—R714. http://dx.doi.org/10.1152/ajpregu.00090.2004.

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Taste-evoked neural responses in the nucleus of the solitary tract (NST) are subject to both excitatory and inhibitory modulation by physiological conditions that influence ingestion. Treatments that induce sodium appetite predominantly reduce NST gustatory responsiveness to sapid stimuli. When sodium appetite is aroused with 10 mg of the diuretic furosemide (Furo), however, NST gustatory neurons exhibit an enhanced responsiveness to NaCl. In addition to inducing a sodium appetite, 10 mg Furo supports a conditioned taste aversion (CTA). A lower, 2-mg dose of Furo induces an equivalent sodium a

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9

K., C. MAJUMDAR, and DAS U. "Studies on Sigmatropic Rearrangements : Regioselective Synthesis of Coumarins, Quinolones and Thiocoumarins with 3,4-Fused Pyran or Furan Ring Systems by Claisen Rearrangement." Journal of Indian Chemical Society Vol. 74, Nov-Dec 1997 (1997): 884–90. https://doi.org/10.5281/zenodo.5900433.

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Department of Chemistry, University of Kalyam, Kalyana-741 235 <em>Manuscript received 4 September 1997</em> A brief review of the regioselective synthesis of pyrano[3,2-<em>c</em>][1]benzopyran-5(2<em>H</em>)-ones, pyrano[3,2-<em>c</em>][1]benzothiapyran-5(2<em>H</em>)-one, pyrano[3,2-<em>c</em>]quinolin-5(2<em>H</em>)-ones, pyrano(2,3-<em>c</em>)[1]benzopyran-5(3<em>H</em>)-ones, 3<em>H</em>-pyrano[2,3-<em>c</em>)quinolin-5(6H)-ones, thiapyrano(2, 3- b) (1)benzothiapyran-5(2<em>H</em>)-ones, thiapyrano[2,3-<em>b]</em> [1]benzopyran-5(2<em>H</em>)-ones, furo[3,2-<em>c</em>] [1] benzopyra

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10

Sirakanyan, Spinelli, Geronikaki, et al. "Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3’,2’:4,5]furo(thieno)[3,2-d]pyrimidin-8-amines." Molecules 24, no. 21 (2019): 3952. http://dx.doi.org/10.3390/molecules24213952.

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Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of pyrido[3’,2’:4,5](furo)thieno[3,2-d]pyrimidines as well as of two new heterocyclic systems: furo[2–e]imidazo[1,2-c]pyrimidine and furo[2,3-e]pyrimido[1,2-c]pyrimidine. Thus, by refluxing the 8-chloro derivatives of pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidines with various amines, the relevant pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidin-8-amines were obtained. Further, the cyclization of some amines under the action of phosphorus oxychlori

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11

Gomonov, Kirill A., Vasilii V. Pelipko, Igor A. Litvinov, et al. "Synthesis of new condensed naphthoquinone, pyran and pyrimidine furancarboxylates." Beilstein Journal of Organic Chemistry 21 (February 12, 2025): 340–47. https://doi.org/10.3762/bjoc.21.24.

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New representatives of dioxodihydronaphtho[2,3-b]furan-, furo[3,2-c][1]benzopyran-, furo[2,3-d]pyrano[4,3-b]pyran-, furo[2',3':4,5]pyrano[3,2-c]chromene-, and furo[2,3-d]pyrimidine carboxylates were obtained from the reactions of alkyl 3-bromo-3-nitroacrylates with representatives of carbo- and heterocyclic CH-acids under simple conditions, without the use of organocatalysts. The structures of the synthesized compounds were proven by a set of physicochemical methods, including X-ray diffraction analysis.

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12

Laxmi, Dandamudi Sri, Suryadevara V. Vardhini, Venkata R. Guttikonda, Mandava V. B. Rao, and Manojit Pal. "Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 8 (2020): 932–40. http://dx.doi.org/10.2174/1871520620666200311102304.

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Background: Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties, including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives, some of them are complex. Objective: The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. Methods: We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond-forming reaction

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13

SHIOTANI, S., and H. MORITA. "ChemInform Abstract: Furopyridines. Part 11. 13C NMR Spectra of 2- or 3-Substituted Furo(2, 3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 23, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199213045.

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14

Wang, Xinye, Yuan Wu, Chuan Ming Wu, et al. "Dibenzo[f,h]furo[2,3-b]quinoxaline-based molecular scaffolds as deep blue fluorescence materials for organic light-emitting diodes." New Journal of Chemistry 46, no. 1 (2022): 419–25. http://dx.doi.org/10.1039/d1nj04934h.

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A novel molecular scaffold, dibenzo[f,h]furo[2,3-b]quinoxaline (3,6-bis(4-isopropylphenyls)-11-phenyldibenzo[f,h]furo[2,3-b]quinoxaline (dP-diBFQ) and furo[2′,3′:5,6]pyrazino[2,3-f][1,10]phenanthroline, were designed, for pure and deep blue emission. OLEDs based on dP-diBFQ shows pure blue emission with CIE coordinates of (0.154, 0.102) and an EQE of 2.28%.

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15

Krutošíková, Alžbeta, Miloslava Dandárová, and Vladimír Bobošík. "Derivatives of Furo[3,2-b]pyrrole." Collection of Czechoslovak Chemical Communications 59, no. 2 (1994): 473–81. http://dx.doi.org/10.1135/cccc19940473.

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A number of methyl 2-substituted, 2,3-disubstituted-4H-furo[3,2-b]pyrrole-5-carboxylates (V - VII) and methyl 1H-benzo[b]furo[3,2-b]pyrrole-2-carboxylate (VIII) was prepared by the thermolysis of corresponding methyl 2-azido-3-(R1,R2-substituted-2-furyl)propenoates (I - IV). N-Methyl and N-benzyl derivatives IX - XVI were prepared at the phase-transfer catalysis conditions. Hydrolysis of some N-methyl and N-benzyl substituted esters furnished corresponding acids XVII - XXII. The hydrazides XXIII - XXX were obtained from corresponding esters and hydrazine hydrate. The preparation of 1-benzylben

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16

Gajdoš, Peter, Soňa Pavlíková, Filip Bureš, and Alžbeta Krutošíková. "2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles: synthesis and reactions." Open Chemistry 3, no. 2 (2005): 311–25. http://dx.doi.org/10.2478/bf02475999.

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AbstractThe synthesis and reactions of methyl 2-[3-(trifluoromethyl)phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylate (1a) are described. Upon reaction with methyl iodide, benzyl chloride, or acetic anhydride, this compound gave N-substituted products 1b-d. By hydrolysis of compounds 1a-c, the corresponding acids 2a-c were formed, or by reaction with hydrazine-hydrate, the corresponding carbohydrazides 3a-c were formed. By heating 2-[3-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By

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17

Sridharan, Makuteswaran, and Karnam J. R. Prasad. "Syntheses of Substituted Furo- and Pyrano-[2,3-a]carbazoles from 2-Cinnamoyl-1-hydroxycarbazoles." Zeitschrift für Naturforschung B 63, no. 9 (2008): 1112–16. http://dx.doi.org/10.1515/znb-2008-0916.

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Reaction of 2-cinnamoyl-1-hydroxycarbazoles 2a - d, with phenacyl bromide, mercuric acetate and H2O2/NaOH under different reaction conditions yielded 2-benzoyl-3-styryl-furo[2,3-a]carbazoles 3a-d, 2-benzylidene-furo[2,3-a]carbazol-3(10H)-ones 4a - d and 3-hydroxy-2-phenylpyrano- [2,3-a]carbazol-4(11H)-ones 5a - d, respectively.

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18

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines.XI.13C NMR Spectra of 2- or 3-Substituted Furo[2,3-b]-, Furo[3,2-b]-, Furo[2,3-c]- and Furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 28, no. 6 (1991): 1469–80. http://dx.doi.org/10.1002/jhet.5570280601.

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19

Koreňová, Anna, Alžbeta Krutošíková, Jaroslav Kováč, and Stanislav Celec. "Synthesis and reactions of furo[3,2-c]pyridine derivatives." Collection of Czechoslovak Chemical Communications 52, no. 1 (1987): 192–98. http://dx.doi.org/10.1135/cccc19870192.

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The synthesis of a new type of condensed heterocycle pyrido[3',4':4,5]furo[3,2-b]indole (V) and 1,2,4-triazolo[4'',3'':1',2']pyrido[3',4':4,5]furo[3,2-b]indoles (IX) is described and the substitution nucleophilic reaction with 2-(2-nitrophenyl)-4-chlorofuro[3,2-c]pyridine (X) is presented.

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20

Mehta, Vaibhav P., Sachin G. Modha, Denis Ermolat'ev, Kristof Van Hecke, Luc Van Meervelt, and Erik V. Van der Eycken. "Diversity-Oriented Synthesis of Substituted Furo[2,3-b]pyrazines." Australian Journal of Chemistry 62, no. 1 (2009): 27. http://dx.doi.org/10.1071/ch08376.

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A highly efficient method for the synthesis of diversely substituted furo[2,3-b]pyrazines has been elaborated. The Ag+- or iodine-mediated electrophilic cyclization of readily generated 5-chloro-3-substituted ethynyl-1-(4-methoxybenzyl)-pyrazin-2(1H)-ones affords substituted furo[2,3-b]pyrazines, which undergo various palladium catalyzed reactions to generate a library of difficult to attain diversely substituted furo[2,3-b]pyrazines.

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21

Wang, Gang, Jie Li, Yixiang Li, et al. "A new type of solid-state luminescent 2-phenylbenzo[g]furo[2,3-b]quinoxaline derivative: synthesis, photophysical characterization and transporting properties." Journal of Materials Chemistry C 7, no. 31 (2019): 9690–97. http://dx.doi.org/10.1039/c9tc02539a.

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We developed a new synthesis method of furo [2,3-b] quinoxaline core and report a new type of 2-phenylbenzo[g]furo [2,3-b] quinoxaline organic semiconductors, which shows 22.1% PLQY in solid powders and hole mobility of 2.58 × 10<sup>−2</sup> cm<sup>2</sup> V<sup>−1</sup> s<sup>−1</sup>.

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22

Gribble, G. W. "Novel chemistry of indole in the synthesis of heterocycles." Pure and Applied Chemistry 75, no. 10 (2003): 1417–32. http://dx.doi.org/10.1351/pac200375101417.

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Indoles that are substituted at the 2- or 3-position with electron-withdrawing groups (nitro, phenylsulfonyl) undergo nucleophilic addition, 1,3-dipolar cycloaddition, and Diels–Alder reactions to give a variety of indoles, pyrroloindoles, and carbazoles. New methods for the synthesis of furo[3,4-b]indoles and the novel ring system furo[3,4-b]pyrrole are described for the first time. Diels–Alder reactions of furo[3,4-b]pyrroles afford indoles after dehydration of the primary cycloadducts. Efficient syntheses of both 2- and 3-nitroindoles from indole are reported, and the first generation and s

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23

Kraľovičová, Eva, Alžbeta Krutošíková, and Jaroslav Kováč. "Preparation and reactions of thieno[3,2-b]furan derivatives." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1685–91. http://dx.doi.org/10.1135/cccc19861685.

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Reactions of 3-(5-aryl-2-furyl)propenoic, 3-(2-benzo[b]furyl)propenoic and 3-(5-ethoxycarbonyl-4H-furo[3,2-b]-2-pyrrolyl)propenoic acids with thionyl chloride in the presence of triethylbenzylammonium chloride were investigated. The obtained 2-arylthieno[3,2-b]-furan-5-carboxylic acid chlorides Ia - Ic and 3-chlorothieno[3,2-b]benzo[b]furan-2-carboxylic acid chloride afforded in substitution nucleophilic reactions the corresponding esters V and carboxylic acids VI which were decarboxylated to VII. 3-Chlorothieno[3,2-b]benzo[b]furan-2-carboxylic acid chloride (Id), 6-ethoxycarbonyl-3-chlorothie

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24

U., C. MASHELKAR, V. WALAVALKAR K., N. ARVINDAKSHAN C., and SINGH ANIL. "Synthesis of Benzofuro[2,3-c]pyridinones, Naphtho[2',3': 5,4]- furo[2,3-c]pyridin-l-ones and Naphtho[ 1',2' : 5,4]furo[2,3-c]pyridin-l-ones. Part-I." Journal of Indian Chemical Society Vol. 69, Jul 1992 (1992): 404–5. https://doi.org/10.5281/zenodo.6085551.

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Organic Research Laboratory, Patkar College, Goregaon (West), Bombay-400 062 <em>Manuscript received 30 December 1991, revised 21 April 1992, accepted 15 May 1992</em> Synthesis of Benzofuro[2,3-<em>c</em>]pyridinones, Naphtho[2',3': 5,4]- furo[2,3-<em>c</em>]pyridin-l-ones and Naphtho[ 1',2' : 5,4]furo[2,3-<em>c</em>]pyridin-l-ones. Part-I.

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25

Vadla, Balakishan, and Sailu Betala. "Novel 1,2,3-Triazole-functionalized pyrido[3',2':4,5]furo[3,2-d]pyrimidin- 4(3H)-one Derivatives: Synthesis, Anticancer Activity, CoMFA and CoMSIA Studies." Letters in Organic Chemistry 17, no. 12 (2020): 969–78. http://dx.doi.org/10.2174/1570178617666200319124017.

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A series of novel triazole functionalized pyrido [3',2':4,5] furo[3,2-d] pyrimidin-4 (3H)-one derivatives 7a-p were prepared from ethyl furo[2,3-b]pyridine-2-carboxylate 3 on reaction with ammonia to afford furo[2,3-b]pyridine-2-carboxamide 4. This compound, on reaction with triethyl orthoformate TEOF, gave compound 5. Compound 5 on propargylation, followed by a reaction with substituted aryl azides under Sharpless reaction conditions, furnished triazole tagged pyrido [3',2':4,5]furo[3,2-d] pyrimidin-4(3H)-one derivatives. All the products 7a-p were screened against four human cancer cell line

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26

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines.XII. Reaction of 3-bromo, 2-phenylthio and 2-phenylthio-3-bromo derivatives of furo[2,3-b]-, furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine with several alkyllithiums." Journal of Heterocyclic Chemistry 29, no. 2 (1992): 413–22. http://dx.doi.org/10.1002/jhet.5570290221.

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27

SHIOTANI, S. "ChemInform Abstract: Furopyridines. Part 14. Synthesis of 2-Aminoalkyl Derivatives of Furo( 2,3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 25, no. 7 (2010): no. http://dx.doi.org/10.1002/chin.199407176.

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Fontes, H. R., S. O. Procopio, A. Cargnelutti Filho, J. M. S. Ferreira, and M. F. Fernandes. "Eficácia do herbicida msma na erradicação de coqueiros infectados com resinose." Planta Daninha 27, no. 4 (2009): 859–65. http://dx.doi.org/10.1590/s0100-83582009000400025.

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Objetivou-se com este trabalho identificar a menor dose do herbicida MSMA e a melhor forma de aplicação, visando à erradicação de coqueiros infectados com resinose. O experimento foi realizado no município de Neópolis-SE, no período de julho a agosto de 2007, utilizando plantas do cultivar Anão-Verde, com 11 anos de idade. O delineamento experimental foi o inteiramente casualizado, com cinco repetições, em esquema fatorial 3 x 2 + 1, sendo três doses do herbicida MSMA (14,4; 21,6; e 28,8 g por planta), duas formas de aplicação dos tratamentos herbicidas (produto injetado no estipe em um furo d

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29

Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally Occurring Furochromones." Pharmaceuticals 15, no. 10 (2022): 1232. http://dx.doi.org/10.3390/ph15101232.

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This study aims to synthesize a new series of furochromone derivatives, evaluate their antimicrobial properties, and improve the permeability of potent compounds to inhibit different types of bacteria and fungi. Hence, Substituted furo[3,2-g]chromene-6-carbonitrile (3a,b) readily form 7-amino-5-methyl-furo [3,2-g]chromene-6-carbonitrile (4a,b) via reduction using sodium borohydride in methanol. The same compounds of (4a,b) were used as starting materials for the synthesis of new furochromone derivatives such as furochromeno [2,3-d]pyrimidines, N- (6-cyano- 5-methyl-furochromene) acetamide, N-(

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Zhou, Rong, Yanli Ding, and Mili Yang. "Synthesis of 2-Substituted Benzo[b]furans/furo-Pyridines Catalyzed by NiCl2." Catalysts 9, no. 12 (2019): 1019. http://dx.doi.org/10.3390/catal9121019.

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The first Ni-catalyzed tandem synthesis of 2-substituted benzo[b]furans/furo-pyridines from 2-halophenols and 1-alkynes was explored under Cu-free and phosphine-free conditions. The protocol was carried out with NiCl2/5-nitro-1, 10-phenanthroline in DMA (N,N-dimethylacetamide) at 120 °C. It was found to be simple, cost effective, and have a wide substrate scope. Additionally, the method is compatible with heteroaryl substrates, resulting in the formation of 2-substituted benzo[b]furans/furo-pyridines in reasonable to good yields.

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Rossa, Thaís A., Jessica C. Neville, Seongmin Paul Jun, Tilo Söhnel, and Jonathan Sperry. "Expanding Heteroaromatic and 2-Aminosugar Chemical Space Accessible from the Biopolymer Chitin." Chemistry 5, no. 3 (2023): 1998–2008. http://dx.doi.org/10.3390/chemistry5030135.

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Herein, we report the expansion of chemical space available from chitin, accessible via the biogenic N-platforms 3A5AF, M4A2C, and di-HAF. The biologically active heteroaromatics furo[3,2-d]pyrimidin-4-one and furo[3,2-d]pyrimidin-4-amine can be selectively accessed from 3A5AF and M4A2C, respectively. The chiral pool synthon di-HAF is a viable substrate for Achmatowicz rearrangement, providing streamlined access to 2-aminosugars possessing a versatile hydroxymethyl group at C5.

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Yang, Ru Chun, Hui Zhu, Xuan Ye Jin, Qiang Xiao, and Yong Ju. "Synthesis of Bicyclic Furo[2,3-d]pyrimidine Deoxynucleosides Conjugated with N-Diisopropylphosphoryl Amino Acids." Advanced Materials Research 881-883 (January 2014): 405–9. http://dx.doi.org/10.4028/www.scientific.net/amr.881-883.405.

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A series of bicyclic furo[2,3-d]pyrimidine nucleosides conjugated with N-diisopropylphosphoryl amino acids were synthesized from 2′-deoxy-5-iodouridine. The key step is its cross coupling with the 5-phthalimido-1-pentyne under Sonogashira reaction condition. 5-Endo-dig electrophilic cyclization catalyzed by AgNO3 is used to afford the furo[2,3-d]pyrimidines.

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Sirakanyan, Samuel N., Victor G. Kartsev, Athina Geronikaki, et al. "Synthesis and Evaluation of Antimicrobial Activity and Molecular Dock - ing of New N-1,3-thiazol-2-ylacetamides of Condensed Pyrido[3',2':4,5] furo(thieno)[3,2-d]pyrimidines." Current Topics in Medicinal Chemistry 20, no. 24 (2020): 2192–209. http://dx.doi.org/10.2174/1568026620666200628145308.

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Background: From the literature it is known that many derivatives of fused thienopyrimidines and furopyrimidines possess broad spectrum of biological activity. Objectives: The current studies describe the synthesis and evaluation of antimicrobial activity of some new N-1,3-thiazol-2-ylacetamides of pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidines. Methods: By cyclocondensation of ethyl 1-aminofuro(thieno)[2,3-b]pyridine-2-carboxylates 1with formamide were converted to the pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones 2.Alkylation of compound 2 with 2-chloro-N-1,3-thiazol-2-ylacetamide

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Krutošíková, Alžbeta, and Mikuláš Hanes. "Substituted 4-Benzylfuro[3,2-b]pyrroles." Collection of Czechoslovak Chemical Communications 57, no. 7 (1992): 1487–94. http://dx.doi.org/10.1135/cccc19921487.

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Preparation of 4-benzylfuro[3,2-b]pyrroles is described and their reactions with selected dienophiles are discussed. Utilization of 4-acetylfuro[3,2-b]pyrroles for preparation of 4-substituted derivatives of furo[3,2-b]pyrrole and the synthesis of ethyl 4-(2- and 4-nitrobenzyl)furo[3,2-b]pyrrole-5-carboxylates for fusing to a 1,4-diazepine system is presented.

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Firdous, Sadiqa, Nida Hassan Ansari, Seik Weng Ngb, Sammer Yousuf, and Abdul Malik. "Crystal Structure of a Novel Furo-Furan Lactone from Heliotropium eichwaldi." Zeitschrift für Naturforschung B 67, no. 3 (2012): 269–71. http://dx.doi.org/10.1515/znb-2012-0314.

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A novel furo-furan lactone 1 has been isolated as fine needles from the ethyl acetate-soluble fraction of Heliotropium eichwaldi. This is the first report of any furo-furan from the genus Heliotropium. β -Sitosterol 3-O-β -D-glucoside 2 has also been obtained for the first time from this source. The structure of 1 was elucidated by X-ray diffraction studies.

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Vasco, Raquel F. V., Rosa M. A. Moyses, Roberto Zatz, and Rosilene M. Elias. "Furosemide Increases the Risk of Hyperparathyroidism in Chronic Kidney Disease." American Journal of Nephrology 43, no. 6 (2016): 421–30. http://dx.doi.org/10.1159/000446449.

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Background: Diuretics are widely used in patients with chronic kidney disease (CKD). While thiazide-like diuretics limit urinary calcium excretion, loop diuretics (LD) promote calcium wasting, which might facilitate the development of secondary hyperparathyroidism (HPT2). We sought to investigate, in CKD patients not on dialysis, the influence of either hydrochlorothiazide (Hydro) or furosemide (Furo) on circulating parathyroid hormone (PTH) and whether such actions are determined by the effects of these compounds on calcium excretion. Methods: Electronic charts of all nephrology outpatients (

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SHIOTANI, S., and H. MORITA. "ChemInform Abstract: Furopyridines. Part 12. Reaction of 3-Bromo, 2-Phenylthio and 2- Phenylthio-3-bromo Derivatives of Furo(2,3-b)-, Furo(3,2-b)-, Furo(2,3- c)- and Furo(3,2-c)pyridine with Several Alkyllithiums." ChemInform 23, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199239201.

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Sleziak, Róbert, and Alžbeta Krutošíková. "Cycloaddition Reactions of Furo[2,3-b]pyrroles." Collection of Czechoslovak Chemical Communications 64, no. 2 (1999): 321–28. http://dx.doi.org/10.1135/cccc19990321.

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Reactions of furo[2,3-b]pyrroles with dimethyl butynedioate and ethyl propynoate were investigated. The reaction course is influenced by the substituents on the fused system. Products of [4+2]cycloaddition to the furan ring leading to indole derivatives have been observed. In the case of the reaction of methyl 6H-furo[2,3-b]pyrrole-5-carboxylate (1a) with dimethyl butynedioate, products of [4+2]cycloaddition to the furan ring as well as of Michael addition to the pyrrole ring leading to N-substituted indole derivative 3 have been observed.

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Vrábel, Viktor, Ľubomír Švorc, Ivana Bradiaková, Jozef Kožíšek, and Alžbeta Krutošíková. "2-[3-(Trifluoromethyl)phenyl]furo[2,3-c]pyridine." Acta Crystallographica Section E Structure Reports Online 63, no. 12 (2007): o4516. http://dx.doi.org/10.1107/s1600536807054062.

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Uher, Michal, Ján Leško, and Ivan Tóth. "Furo[2,3-d]thiazoles." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1678–84. http://dx.doi.org/10.1135/cccc19861678.

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Carbonyl isothiocyanates react with 5-amino-2-furancarboxylates to give the corresponding acylthioureas which cyclize to condensed derivatives related to furo[2,3-d]thiazoles. Structure of these substances was corroborated by IR, mass, 1H and 13C{1H}NMR spectral means.

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41

Krutošíková, Alžbeta, Miloslava Dandárová, Juraj Alföldi, and Jaroslav Kováč. "Addition and cycloaddition reactions of furo[3,2-b]pyrroles and their benzo[b] analogues: An NMR study of structure of products." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1770–78. http://dx.doi.org/10.1135/cccc19881770.

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Reaction of furo[3,2-b]pyrroles and their benzo[b] analogues with dimethyl butynedioate and ethyl propyonate were investigated. The reaction course is influenced by substituents on the system. Products of [4 + 2] cycloaddition to the furan or pyrrole nucleus as well as products of Michael addition to the benzo[b]furo[3,2-b]pyrrole system have been found. The structure of the products has been proven by 1H NMR and 13C NMR spectroscopy.

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42

Shokol, Tetyana, Anastasiya Suprun, Viktoriia Moskvina, and Volodymyr Khilya. "Hetarenocoumarins based on 7-hydroxy-3-(benzothiazol-2-yl)coumarin." French-Ukrainian Journal of Chemistry 9, no. 2 (2021): 83–93. http://dx.doi.org/10.17721/fujcv9i2p83-93.

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The syntheses of angular hetarenocoumarins, namely chromeno[8,7-e][1,3]oxazin-2-ones and furo[2,3-h]chromen-2-one, have been accomplished starting from 7-hydroxy-3-(benzothiazol-2-yl)-coumarin using aminomethylation and formylation reactions.

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43

Milyutin, Constantine V., Andrey N. Komogortsev, and Boris V. Lichitsky. "Study of the interaction of 2H-furo[3,2-b]pyran-2-ones with nitrogen-containing nucleophiles." Beilstein Journal of Organic Chemistry 21 (March 13, 2025): 556–63. https://doi.org/10.3762/bjoc.21.44.

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For the first time, the reaction of substituted 2H-furo[3,2-b]pyran-2-ones with diverse N-nucleophiles was investigated. It was shown that the direction of the process depends on the type of employed nitrogen-containing reagent. For example, condensation with aliphatic amines leads to 2H-furo[3,2-b]pyran-2,7(3H)-diones bearing an exocyclic enamine moiety. At the same time, interaction with dinucleophiles results in recyclization accompanied by opening of the furan ring. Relied on the aforementioned process a general method for the synthesis of substituted pyrazol-3-ones with allomaltol fragmen

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44

Singh, Shivendra, Anvita Srivastava, Shaikh M. Mobin, and Sampak Samanta. "A remarkable solvent effect on the reaction of 4-hydroxycoumarin with (E)-3-aryl-2-nitroprop-2-enol: Facile synthesis of highly substituted furo/pyrano[3,2-c]chromenes." RSC Advances 5, no. 7 (2015): 5010–14. http://dx.doi.org/10.1039/c4ra10610e.

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Morita, Hiroyuki, and Shunsaku Shiotani. "Furopyridines. VII. Preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 24, no. 2 (1987): 373–76. http://dx.doi.org/10.1002/jhet.5570240216.

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Park, Hee Jung, Ok-Kyung Yang, Young Chul Park, and Eul Kgun Yum. "Synthesis of 2-Substituted Furo[2,3-b]- and Furo[3,2-c]quinolines via Heterogeneous Palladium-catalyzed Heteroannulation." Bulletin of the Korean Chemical Society 37, no. 6 (2016): 958–61. http://dx.doi.org/10.1002/bkcs.10783.

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47

Besharati-Seidani, Tayebeh, Ali Keivanloo, Babak Kaboudin, and Tsutomu Yokomatsu. "Efficient synthesis of 2-phenyl-3-substituted furo/thieno[2,3-b]quinoxalines via Sonogashira coupling reaction followed by iodocyclization and subsequent palladium-catalyzed cross-coupling reactions." RSC Advances 6, no. 87 (2016): 83901–8. http://dx.doi.org/10.1039/c6ra15425e.

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In this paper, we report the successful synthesis of new 2-phenyl-3-substituted furo/thieno[2,3-b]quinoxaline derivatives from 2-chloro-3-methoxyquinoxaline and 2-chloro-3-(methylthio)quinoxaline by a three-step approach.

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48

Krutošíková, Alžbeta, Slavomír Mastik, Miloslava Dandárová, and Antonín Lyčka. "Synthesis and Reactions of 8-Hydrazinofuro[2',3':4,5]pyrrolo-[1,2-d][1,2,4]triazines." Collection of Czechoslovak Chemical Communications 62, no. 10 (1997): 1612–22. http://dx.doi.org/10.1135/cccc19971612.

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5-Ethyl-8-hydrazinofuro[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine (4a) and its 2-methyl derivative 4b were prepared from 4H-furo[3,2-b]pyrrole-5-carbohydrazides 1a and 1b, respectively. Compounds 1a and 1b reacted with triethyl orthopropionate to give 2a and 2b which afforded with phosphorus(V) sulfide corresponding thiones 3a and 3b. The title compounds 4a and 4b were made by treatment of 3a and 3b with hydrazine hydrate. By reactions of triethyl orthoesters with the title compounds and similar derivatives furo[2'3':4,5]pyrrolo[1,2-d][1,2,4]triazolo[3,4-f][1,2,4]triazines 5a-5j were prepared. R

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Brambilla, Elisa, Valentina Pirovano, Matteo Giannangeli, Giorgio Abbiati, Alessandro Caselli, and Elisabetta Rossi. "Gold-catalyzed cascade reactions of 4H-furo[3,2-b]indoles with propargyl esters: synthesis of 2-alkenylidene-3-oxoindolines." Organic Chemistry Frontiers 6, no. 17 (2019): 3078–84. http://dx.doi.org/10.1039/c9qo00647h.

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Nikumbh, Satish P., Akula Raghunadh, T. Srinivasa Rao, et al. "A cascade reaction for the new and direct synthesis of indolofuroquinoxalines." RSC Advances 6, no. 28 (2016): 23489–97. http://dx.doi.org/10.1039/c6ra03556f.

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