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Dissertations / Theses on the topic 'Furo[3,2-c]quinolines'

Author: Grafiati

Published: 7 September 2021

Last updated: 29 July 2025

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1

Chartoire, Anthony. "Synthèse et fonctionnalisation des furo[3,2-b]- et [2,3-c]pyridines par voie organométallique." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10081/document.

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Le travail décrit dans ce mémoire concerne l'étude de la métallation régiosélective de deux bicycles fusionnés complexes : les furo[3,2-b]- et [2,3-c]pyridines. L'influence de la nature du système basique sur le cours de la réaction et sur la régiosélectivité de la lithiation a été étudiée avec différentes bases : n-BuLi, LTMP, LDA et [n-BuLi/LiDMAE]. D'un point de vue fondamental, cette étude nous a permis d'établir quelques règles pour la fonctionnalisation des hétérocycles complexes, ce qui nous a conduit à l'obtention efficace et rapide d'une vaste chimiothèque de furo[3,2-b]- et [2,3-c]py

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2

Chi, Hung Nguyen. "Synthèse et étude de nouveaux analogues tetracycliques et tricycliques des ellipticines et aza-9 ellipticines." Paris 11, 1985. http://www.theses.fr/1985PA112290.

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La présente thèse concerne la synthèse de nouveaux analogues tétracycliques et tricycliques des Ellipticines et aza-9 Ellipticines, ainsi que l'étude de L'étude de leurs propriétés biologiques. L’étude de la lithiation des furo-et pyrrolo [3,2-c] pyridines présentée dans le premier chapitre montre que l'échange avec le ter. Butyl lithium s'effectue sur le sommet 2 de ces hétérocycles. Cela permet d'accéder à divers dérivés fonctionnalisés sur leur sommet 2 à partir desquels nous avons pu accéder d'une part à des pyrido [4,3-b] benzo [f] indoles et d'autre part à des pyrido [3',4': 4,5] pyrrolo

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3

Rocha, Djenisa Helene Ascenção. "Estudos de síntese e transformação de cromonas e 4-quinolonas." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14472.

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Doutoramento em Química<br>Esta dissertação está dividida em duas partes. Na primeira parte reportam-se métodos de síntese de (E)-3-estirilflavonas e (E)/(Z)-2-aril- 4-cloro-3-estiril-2H-cromenos e estudos de ciclização das (E)-3- estirilflavonas em 5-arilbenzo[c]xantonas. Na segunda parte desenvolveram-se novas rotas de síntese de (E)-2-aril-3-estiril-4- quinolonas e posterior transformação em 5-fenil-12- metilbenzo[c]acridonas e 2,4-diarilfuro[3,2-c]quinolinas. Nesta parte estudou-se também a transformação de 2-aril-4-cloro-1,2-dihidroquinolina- 1,3-dicarbaldeídos em (E)/(Z)-2-aril-4

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4

Hong, Shao-Hao, and 洪紹豪. "Preparation of Bis-heterocycles and Furo[3,2-c]coumarins via Phosphonium Salt Intermediates." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/52739m.

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5

Chiang, Hao-Tang, and 蔣浩堂. "Studies on the Synthesis and Biological Activities of Furo[3,2-c]quinoline Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/77765232281054811928.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>92<br>The quinoline alkaloids isolated from the Rutaceac family of plants have various biological activities such as anticancer, antibacterial and antiviral effects. Polycondensed heterocyclic aromatic compounds having a planar structure can intercalate into DNA to inhibit the replication. We have synthesized the derivatives of furoquinoline by changing the substitutent at C4, such as aniline group and aliphatic amines, to improve the selectivity and specificity of the compounds against the growth of various cancer cells. The furo[3,2-c]quinolin-4-yl-(3-methoxyph

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6

Ferreira, João Paulo de Sousa. "Novel heterocyclic quinoline/quinolone-based compounds as acetylcholinesterase inhibitors and antioxidant agents." Master's thesis, 2019. http://hdl.handle.net/10773/30140.

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Alzheimer’s disease represents about 60-80% of all cases of dementia, mainly affecting people over 65 years. This pathology is caracterizated at the molecular level by the presence of senile plaques (Aβ amyloid peptides aggregates) and neurofibrillary tangles (NFTs). In addition, several experimental studies have revealed that acetylcholinesterase (AChE) enzyme plays a crucial role in the development of Alzheimer’s disease, leading to the formation of NFTs and senile plaques. Oxidative stress is a cause and consequence of this pathology, activating signalling pathways that promote Aβ pe

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7

Yeh, Wen-Pin, and 葉文賓. "Microwave-Assisted Traceless Synthesis of Disubstituted Indole Alkaloids, pyrrolo[3,2-c]quinolines and Piperazino-Oxazinones derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/31966988632514439734.

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博士<br>國立東華大學<br>化學系<br>96<br>This thesis illustrates the use of Microwave technology for the synthesis of tetrahydro-β-carbolinehydantoins, 2,5-diketo piperazine functionalized β-carboline, pyrrolo[3,2-c]quinolines, and N-Cyanoamide substituted Piperazino-Oxazinones, which provides access to the structurally diverse collection of biologically active molecules. The work in this thesis is presented in the following four parts. The first part makes use of PEG linked Boc tryptophan to construct the β-carboline skeleton via the Pictet-Spengler reaction using a variety of aldehydes. Reaction of thes

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8

Chang, Chih-Kai, and 張智凱. "The pharmacokinetics of furo[3,2-c]quinoline derivative, a new synthetic antitumor drug of amsacrine analogs." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/61216869672731019440.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>Amsacrine is an antitumor drug against acute adult leukemia and lymphoma. The two model drugs, PK-A2 and PK-A3, are new antitumor compounds and synthesized from the substitution and modification of the main chemical structure of amsacrine. So far, there is no data to describe the pharmacokinetic characters of the two model drugs. In this study, drugs were administered by IV bolus into Wistar rats weighted 190 to 220 g. The blood samples were extracted with dichlomethane and then analyzed by HPLC method. Finally, we discussed the individual pharmacokinetic char

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9

Wang and 王建益. "Chemoselective synthesis of substituted benzofurans and furo[3,2-c]coumarins from functional phosphorus zwitterions via intramolecular Wittig reactions." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/5q3v84.

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碩士<br>國立臺灣師範大學<br>化學系<br>103<br>The thesis is divided into two parts： In the first part, chemoselective synthesis of substituted benzofurans and furo[3,2-c]coumarins from functional phosphorus zwitterions via intramolecular Wittig reactions is described. Based on our previous studies, a phosphine-triggered intramolecular Wittig reaction with high efficiency via phosphorus zwitterions as key intermediates has been developed. The studies included chemoselectivities of acylations and intramolecular Wittig reactions. By employing different addition sequence of the acyl chloride and phosphine reage

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10

Lee, Chia-Jui, and 李家睿. "Preparation of Functional Phosphorus Zwitterions from Activated Alkanes, Aldehydes, and Tributylphosphine: Synthesis of Polysubstituted Furo[3,2-c]coumarins." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/70708415242184143967.

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碩士<br>國立臺灣師範大學<br>化學系<br>101<br>A novel synthetic protocol for the preparation of functional phosphorus zwitterions via organocatalytic three-component reactions of activated alkanes, aldehydes, and tributylphosphine has been successfully developed. A wide variety of functional alkanes and aldehydes can be successfully employed, and numerous corresponding phosphorus zwitterions can be generated in the presence of tributylphosphine and catalysts, such as pyrrolidine and benzoic acid, in high yields. The reaction mechanism is supposed to be via the organocatalytic Knoevenagel condensation reacti

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11

Wu, Zong-Ze, and 吳宗澤. "Synthesis of polysubstituted furo[3,2-c]coumarins and polysubstituted naphtho[2,3-b]furan-4,9-diones via intramolecular Wittig reaction." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/05454314551540426926.

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碩士<br>國立臺灣師範大學<br>化學系<br>100<br>Furo[3,2-c]coumarin is one kind of the heterocyclic compounds abundant in nature. It has attracted scientists much attention because of its broad pharmacological activities. In 2010, our research reported a general preparation of tetrasubstituted furans via phosphorus zwitterions as key intermediates. Based on these observation, we want to develop a new synthetic protocol for the preparation of furo[3,2-c]coumarins using the corresponding stable phosphorus zwitterions. These new, stable phosphorus zwitterions can be prepared by our developed methodology starting

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12

Huang, Chi-Tsung, and 黃啟宗. "1.Synthesis,Pyrolytic and Photolytic Study of Furo[3,2-c] Pyran-4-one2.Pyrolytic Study of Benzoic 1,2-Dimethyl-3-Indoly Anhydride." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/19489185429093925414.

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碩士<br>國立中山大學<br>化學系研究所<br>92<br>(1)Flash vaccum pyrolysis of furo[3,2-c]pyran-4-one gave starting material, but in photolytic system we gave a isomer: furo[2,3-c]pyran-5-one. (2)Flash vaccum pyrolysis of benzoic 1,2-dimethyl-3-indoly anhydride,via a ketene intermediate,gave a dimmer.

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13

Tsai, Cheng-Che, та 蔡政哲. "Investigation of phosphine-mediated or catalyzed reactions : synthesis of furo[3,2-c]chromen-4-one derivatives or β-acylated 2-arylidene-1,3-indandiones". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/72881699469199977003.

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14

Lee, Chia-Jui, та 李家睿. "Direct β-Acylation of 2-Arylidene-1,3-indandiones withAcyl Chlorides Catalyzed by OrganophosphanesPreparation of Furo[3,2-c]coumarins from 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization SequenceSynthesis of Functionalized Furans via Chemoselective Reduction/Wittig reaction Using Catalytic Triethylamine and Phosphine". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/58559388773676205184.

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博士<br>國立臺灣師範大學<br>化學系<br>104<br>In part I, we have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives. In part II, electrophilic addition of acyl chlorides to 3- cinnamoyl-4-hydroxy

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15

Lesenyeho, Lehlogonolo Godfrey. "Palladium-catalyzed heteroannulation of 2-ARYL- 3-IODO-4-(Phenylamino)quinolines and 4-(N,N-allylphenylamino)-2-ARYL-3-iodoquinolines." Diss., 2010. http://hdl.handle.net/10500/3970.

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The previously described 2-aryl-4-chloro-3-iodoquinolines were prepared following literature procedure and in turn converted to the corresponding hitherto unknown 2-aryl-3-iodo-4-(phenylamino)quinoline derivatives using aniline in refluxing ethanol. These 2-aryl-3-iodo-4-(phenylamino)quinolines were reacted with allybromide in ethanol at room temperature to afford 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives. The 2-aryl-3-iodo-4-(phenylamino)quinoline and 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives were subjected to metal-catalysed carbon-carbon bond formations.

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