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Journal articles on the topic 'Furo[3,2-c]quinolines'

Author: Grafiati

Published: 7 September 2021

Last updated: 29 July 2025

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1

Prasanna, T. S. R., and K. Mohana Raju. "T3P- A Novel Catalyst for Aza-Diels-Alder Reaction: One-Pot Synthesis of Pyrano[3,2-c]quinolines and furano[3,2-c]quinolines." E-Journal of Chemistry 8, s1 (2011): S420—S424. http://dx.doi.org/10.1155/2011/565021.

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T3P was found to be an efficient catalyst for the Aza-Diels–Alder reactions of aldimines with dihydropyran or dihydrofuran to afford the corresponding pyrano-and furo [3,2-c]quinolines in high yields with high diastereoselectivity in a short period of time.

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2

Abd El-Nabi, Hisham A., and A. M. Now El-Din. "SYNTHESIS AND REACTIONS OF FURO[3,2-c]QUINOLINES AND FVRO[3,2-c]COUMARINS." Organic Preparations and Procedures International 35, no. 5 (2003): 509–14. http://dx.doi.org/10.1080/00304940309355862.

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3

Bencková, Mária, and Alžbeta Krutošíková. "5-Aminofuro[3,2-c]pyridinium Tosylates and Substituted Furo[3,2-c]pyridine N-Oxides: Synthesis and Reactions." Collection of Czechoslovak Chemical Communications 64, no. 3 (1999): 539–47. http://dx.doi.org/10.1135/cccc19990539.

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5-Aminofuro[3,2-c]pyridinium tosylates 2a-2c were synthesized by direct N-amination of furo[3,2-c]pyridines 1a-1c with O-(4-methylbenzenesulfonyl)hydroxylamine in dichloromethane. Zwitterionic furo[3,2-c]pyridinium N-imides 3a-3c generated from 2a-2c and anhydrous potassium carbonate in N,N-dimethylformamide afforded by 1,3-dipolar cycloaddition reactions with dimethyl butynedioate or ethyl propiolate the corresponding furo[3,2-c]pyrazolo[1,5-a]pyridinecarboxylic esters 4a-4c and 5a-5c. Furo[3,2-c]pyridine N-oxides 6a-6c and their benzo derivative 6d were synthesized by reaction of 1 with 3-ch

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4

Sabitha, Gowravaram, M. Shashi Kumar Reddy, K. Arundhathi, and J. S. Yadav. "VCl3-catalyzed aza-Diels-Alder reaction: one-pot synthesis of pyrano[3,2-c]- and furo[3,2-c]quinolines." Arkivoc 2006, no. 6 (2006): 153–60. http://dx.doi.org/10.3998/ark.5550190.0007.613.

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5

Yun, Ma, Qian Chemg-Tao, Xie Mei-Hua, and Sun Jie. "Synthesis of furo[3,2-c]- and pyrano[3,2-c ]quinolines by lanthanide triflate catalyzed imino-Diels-Alder reaction." Chinese Journal of Chemistry 18, no. 3 (2010): 377–83. http://dx.doi.org/10.1002/cjoc.20000180322.

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6

K., C. MAJUMDAR, and DAS U. "Studies on Sigmatropic Rearrangements : Regioselective Synthesis of Coumarins, Quinolones and Thiocoumarins with 3,4-Fused Pyran or Furan Ring Systems by Claisen Rearrangement." Journal of Indian Chemical Society Vol. 74, Nov-Dec 1997 (1997): 884–90. https://doi.org/10.5281/zenodo.5900433.

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Department of Chemistry, University of Kalyam, Kalyana-741 235 <em>Manuscript received 4 September 1997</em> A brief review of the regioselective synthesis of pyrano[3,2-<em>c</em>][1]benzopyran-5(2<em>H</em>)-ones, pyrano[3,2-<em>c</em>][1]benzothiapyran-5(2<em>H</em>)-one, pyrano[3,2-<em>c</em>]quinolin-5(2<em>H</em>)-ones, pyrano(2,3-<em>c</em>)[1]benzopyran-5(3<em>H</em>)-ones, 3<em>H</em>-pyrano[2,3-<em>c</em>)quinolin-5(6H)-ones, thiapyrano(2, 3- b) (1)benzothiapyran-5(2<em>H</em>)-ones, thiapyrano[2,3-<em>b]</em> [1]benzopyran-5(2<em>H</em>)-ones, furo[3,2-<em>c</em>] [1] benzopyra

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7

Salgado, Arturo R. M., Carlos E. P. Galvis, Vladimir V. Kouznetsov, and Carlos Mario Meléndez. "Synthesis of endo-fused 5-unsubstituted Hexahydro-2H-pyrano[3,2-c]quinolinesvia Sequential Sc(OTf)3-catalyzed Cationic Imino-Diels-Alder Reaction/N-debenzylation using N-benzylanilines, 3,4-dihydro-2H-pyran and Paraformaldehyde under MW Irradiation." Current Organic Synthesis 18, no. 5 (2021): 431–42. http://dx.doi.org/10.2174/1570179418666210113160949.

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Background: Hexahydro-2H-pyrano[3,2-c]quinolines are known to have antibacterial, antifungal, and antitumor properties. Great efforts have been made to develop new synthetic methods that lead to the synthesis of valuable libraries. Extensive methodologies, low yields, excessive amounts of catalyst and expensive reactants are some of the limitations of current methodologies. Aim and Objective: Developing a useful and efficient method to construct diversely substituted hexahydro-2Hpyrano[ 3,2-c]quinolines into good to excellent yields through a cationic imino-Diels-Alder/N-debenzylation methodol

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8

Park, Hee Jung, Ok-Kyung Yang, Young Chul Park, and Eul Kgun Yum. "Synthesis of 2-Substituted Furo[2,3-b]- and Furo[3,2-c]quinolines via Heterogeneous Palladium-catalyzed Heteroannulation." Bulletin of the Korean Chemical Society 37, no. 6 (2016): 958–61. http://dx.doi.org/10.1002/bkcs.10783.

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9

Ma, Yun, Changtao Qian, Meihua Xie, and Jie Sun. "Lanthanide Chloride Catalyzed Imino Diels−Alder Reaction. One-Pot Synthesis of Pyrano[3,2-c]- and Furo[3,2-c]quinolines." Journal of Organic Chemistry 64, no. 17 (1999): 6462–67. http://dx.doi.org/10.1021/jo982220p.

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10

Bois-Choussy, Michèle, and Ren� Beugelmans. "A Convenient Access to Furo[3,2-h]quinolines and to Furo[3,2-b]pyridines via SRN1 Reactions." HETEROCYCLES 26, no. 7 (1987): 1863. http://dx.doi.org/10.3987/r-1987-07-1863.

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11

Laxmi, Dandamudi Sri, Suryadevara V. Vardhini, Venkata R. Guttikonda, Mandava V. B. Rao, and Manojit Pal. "Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 8 (2020): 932–40. http://dx.doi.org/10.2174/1871520620666200311102304.

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Background: Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties, including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives, some of them are complex. Objective: The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. Methods: We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond-forming reaction

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12

Koreňová, Anna, Alžbeta Krutošíková, Jaroslav Kováč, and Stanislav Celec. "Synthesis and reactions of furo[3,2-c]pyridine derivatives." Collection of Czechoslovak Chemical Communications 52, no. 1 (1987): 192–98. http://dx.doi.org/10.1135/cccc19870192.

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The synthesis of a new type of condensed heterocycle pyrido[3',4':4,5]furo[3,2-b]indole (V) and 1,2,4-triazolo[4'',3'':1',2']pyrido[3',4':4,5]furo[3,2-b]indoles (IX) is described and the substitution nucleophilic reaction with 2-(2-nitrophenyl)-4-chlorofuro[3,2-c]pyridine (X) is presented.

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13

Gomonov, Kirill A., Vasilii V. Pelipko, Igor A. Litvinov, et al. "Synthesis of new condensed naphthoquinone, pyran and pyrimidine furancarboxylates." Beilstein Journal of Organic Chemistry 21 (February 12, 2025): 340–47. https://doi.org/10.3762/bjoc.21.24.

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New representatives of dioxodihydronaphtho[2,3-b]furan-, furo[3,2-c][1]benzopyran-, furo[2,3-d]pyrano[4,3-b]pyran-, furo[2',3':4,5]pyrano[3,2-c]chromene-, and furo[2,3-d]pyrimidine carboxylates were obtained from the reactions of alkyl 3-bromo-3-nitroacrylates with representatives of carbo- and heterocyclic CH-acids under simple conditions, without the use of organocatalysts. The structures of the synthesized compounds were proven by a set of physicochemical methods, including X-ray diffraction analysis.

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14

Akchurin, Igor O., Anna I. Yakhutina, Andrei Y. Bochkov, Natalya P. Solovjova, and Valerii F. Traven. "Synthesis of novel push-pull fluorescent dyes – 7-(diethylamino)furo[3,2-c]coumarin and 7-(diethylamino)thieno[3,2-c]coumarin derivatives." Heterocyclic Communications 24, no. 2 (2018): 85–91. http://dx.doi.org/10.1515/hc-2017-0253.

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AbstractNovel push-pull fluorescent dyes, 7-(diethylamino)furo[3,2-c]coumarin and 7-(diethylamino)thieno[3,2-c]coumarin derivatives, were designed and synthesized using formyl derivatives of furo- and thieno[3,2-c]coumarins as key intermediates. Electron absorption and emission spectra of the dyes were recorded in different solvents. The longest-wave bands in the electron absorption spectra of the dyes are suggested to be of push-pull nature.

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15

Rao, V. Sudhakar, and Malleshwar Darbarwar. "A Convenient Synthesis of 3-Aryl-4-oxo-4,5-dihydro Furo [3,2-c] Quinolines." Synthetic Communications 19, no. 15 (1989): 2713–19. http://dx.doi.org/10.1080/00397918908053065.

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16

Borrione, Elisabetta, Maurizio Prato, Gianfranco Scorrano, Mariano Stivanello, and Vittorio Lucchini. "Synthesis and cycloaddition reactions of ethyl glyoxylate imines. Synthesis of substituted furo-[3,2-c]quinolines and 7H-indeno[2,1-c]quinolines." Journal of Heterocyclic Chemistry 25, no. 6 (1988): 1831–35. http://dx.doi.org/10.1002/jhet.5570250644.

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17

Gajdoš, Peter, Soňa Pavlíková, Filip Bureš, and Alžbeta Krutošíková. "2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles: synthesis and reactions." Open Chemistry 3, no. 2 (2005): 311–25. http://dx.doi.org/10.2478/bf02475999.

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AbstractThe synthesis and reactions of methyl 2-[3-(trifluoromethyl)phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylate (1a) are described. Upon reaction with methyl iodide, benzyl chloride, or acetic anhydride, this compound gave N-substituted products 1b-d. By hydrolysis of compounds 1a-c, the corresponding acids 2a-c were formed, or by reaction with hydrazine-hydrate, the corresponding carbohydrazides 3a-c were formed. By heating 2-[3-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By

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18

Sirakanyan, Spinelli, Geronikaki, et al. "Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3’,2’:4,5]furo(thieno)[3,2-d]pyrimidin-8-amines." Molecules 24, no. 21 (2019): 3952. http://dx.doi.org/10.3390/molecules24213952.

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Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of pyrido[3’,2’:4,5](furo)thieno[3,2-d]pyrimidines as well as of two new heterocyclic systems: furo[2–e]imidazo[1,2-c]pyrimidine and furo[2,3-e]pyrimido[1,2-c]pyrimidine. Thus, by refluxing the 8-chloro derivatives of pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidines with various amines, the relevant pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidin-8-amines were obtained. Further, the cyclization of some amines under the action of phosphorus oxychlori

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19

Shiotani, Shunsaku. "Furopyridines.XIV. Synthesis of 2-aminoalkyl derivatives of furo[2,3-b]-, furo[3,2-b], furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 30, no. 4 (1993): 1035–39. http://dx.doi.org/10.1002/jhet.5570300432.

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20

Ma, Yun, Changtao Qian, Meihua Xie, and Jie Sun. "ChemInform Abstract: Lanthanoid Chloride Catalyzed Imino Diels-Alder Reaction. One-Pot Synthesis of Pyrano[3,2-c]- and Furo[3,2-c]quinolines." ChemInform 31, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.200001176.

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21

Elagamey, Abdel Ghani A., Salah Z. Sawllim, Fathy M. A. El-Taweel, and Mohamed H. Elnagdi. "Nitriles in heterocyclic synthesis: Novel syntheses of benzo[b]pyrans, naphtho[1,2-b]pyrans, naphtho[2,1-b]pyrans, pyrano[3,2-h]quinolines and pyrano[3,2-c]quinolines." Collection of Czechoslovak Chemical Communications 53, no. 7 (1988): 1534–38. http://dx.doi.org/10.1135/cccc19881534.

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Benzo[b]pyrans, naphtho[1,2-b]pyrans, naphtho[2,1-b]pyrans, pyrano[3,2-h]quinolines, and pyrano[3,2-c]quinolines were synthesized by the reaction of cinnamonitriles with phenols, naphthols, 8-hydroxyquinoline, and 1-methyl-4-hydroxy-2-quinoline.

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22

DUVAL, O., and L. M. GOMES. "ChemInform Abstract: Novel Access to Benzo(h)furo(3,2-c)quinolines, Isosteric Analogues of Benzo(c)phenanthridines." ChemInform 22, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.199130272.

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23

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines. X. Synthesis of tricyclic heterocycles, furo[2,3-b:4,5-c']-, furo[3,2-b:4,5-c']-, furo[2,3-c:4,5-c']- and furo[3,2-c:4,5-c']dipyridine." Journal of Heterocyclic Chemistry 27, no. 3 (1990): 637–42. http://dx.doi.org/10.1002/jhet.5570270330.

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24

Goerlitzer, K., J. Fabian, P. G. Jones, P. Frohberg, and G. Drutkowski. "ChemInform Abstract: Furo[2,3-c]quinolines and Furo[3,4-c]quinolines - Synthesis and Investigation of Lipoxygenase Inhibition." ChemInform 33, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.200226159.

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25

Hrašna, Martin, Eva Ürgeová, and Alžbeta Krutošíková. "Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting Compounds." Nova Biotechnologica et Chimica 11, no. 1 (2012): 73–85. http://dx.doi.org/10.2478/v10296-012-0008-x.

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Synthesis, Complex Compounds and Antimicrobial Activity of Some Derivatives of Furo[3,2-C]Pyridine and Their Starting CompoundsSome [3,2-c]pyridine derivatives were synthesized. 3-(Furan-2-yl)propenoic acid (1a) was prepared from furan-2-carbaldehyde under the Perkin's conditions. Obtained acid was converted to the corresponding azide3, which in turn was cyclized to give furo[3,2-c]pyridin-4(5H)-one (4a). The reaction of pyridone4awith phosphorus oxychloride rendered the chloroderivative7a, which was treated in the condition of Suzuki coupling reaction with boronic acid to give 4-phenylfuro[3,

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26

Osyanin, V. A., D. V. Osipov, and Yu N. Klimochkin. "Novel Method of Synthesis of 2,3-Dihydro-Furo[3,2-h]Quinolines." Chemistry of Heterocyclic Compounds 48, no. 7 (2012): 993–96. http://dx.doi.org/10.1007/s10593-012-1090-3.

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27

Shiotani, Shunsaku, Hiroyuki Morita, Toshimasa Ishida, and Yasuko In. "Furopyridines.IX. Syntheses and properties of 3-ethoxy derivatives of furo[2,3-b]-, furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 25, no. 4 (1988): 1205–13. http://dx.doi.org/10.1002/jhet.5570250431.

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28

Shiotani, Shunsaku, and Hiroyuki Morita. "Furopyridines.XI.13C NMR Spectra of 2- or 3-Substituted Furo[2,3-b]-, Furo[3,2-b]-, Furo[2,3-c]- and Furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 28, no. 6 (1991): 1469–80. http://dx.doi.org/10.1002/jhet.5570280601.

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29

Majumdar, Krishna C., and Trijit Bhattacharyya. "Regioselective Synthesis of Furo[3,2-c][1]benzopyran-4-one and Furo[3,2-c]quinolin-4-one." Journal of Chemical Research, no. 7 (1997): 244–45. http://dx.doi.org/10.1039/a607538j.

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30

SAHA, Pritam, Subhrangsu Taran, and Koushik Mukherjee. "Zinc Aluminate (ZnAl₂O₄) Supported and Catalyzed Highly Effective Sonogashira Cross-Coupling and Cyclization Reaction Under Microwave Irradiation Used in One-Pot Tandem Synthesis of Furo[3,2-H]Quinolines." ECS Transactions 107, no. 1 (2022): 209–23. http://dx.doi.org/10.1149/10701.0209ecst.

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The Sonogashira reaction (SR) which forms a C–C bond by cross-coupling a vinyl/aryl halide with a terminal alkyne, uses a palladium species as a catalyst, with a copper species as co-catalysts and a phosphine/amine as ligand/base in its actual form. This efficient reaction is beneficial in synthesizing heterocycles, nanomaterials, medicines and other complex molecules with biological functions. However, in this study, we were able to successfully execute the SR under microwave irradiation, using zinc aluminate (ZnAl2O4) as the catalyst, without using palladium, phosphines/amine as a ligand/bas

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31

Lin, Ying, Dong Xing, Wen-Biao Wu, et al. "Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents." Molecules 25, no. 1 (2020): 203. http://dx.doi.org/10.3390/molecules25010203.

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Herein, we design and synthesize an array of benzofuro[3,2-c]quinolines starting from 3-(2-methoxyphenyl)quinolin-4(1H)ones via a sequential chlorination/demethylation, intramolecular cyclization pathway. This sequential transformation was efficient, conducted under metal-free and mild reaction conditions, and yielded corresponding benzofuro[3,2-c]quinolines in high yields. In vitro biological evaluation indicated that such type of compounds showed excellent antileukemia activity and selectivity, and therefore may offer a promising hit compound for developing antileukemia compounds.

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32

SHIOTANI, S. "ChemInform Abstract: Furopyridines. Part 14. Synthesis of 2-Aminoalkyl Derivatives of Furo( 2,3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 25, no. 7 (2010): no. http://dx.doi.org/10.1002/chin.199407176.

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33

Venkataraman, Subramanian, Deepak Kumar Barange, and Manojit Pal. "One-pot synthesis of 2-substituted furo[3,2-c]quinolines via tandem coupling–cyclization under Pd/C-copper catalysis." Tetrahedron Letters 47, no. 41 (2006): 7317–22. http://dx.doi.org/10.1016/j.tetlet.2006.08.025.

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34

Bardasov, Ivan N., Denis L. Mikhailov, Anastasiya U. Alekseeva, Oleg V. Ershov, and Viktor A. Tafeenko. "A new heterocycle: furo[3,2-c]isoselenazole." Tetrahedron Letters 57, no. 25 (2016): 2772–73. http://dx.doi.org/10.1016/j.tetlet.2016.05.032.

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35

Ravikumar, K., B. Sridhar, M. Mahesh, and V. V. Narayana Reddy. "A diastereoisomer of furo[3,2-c]quinoline." Acta Crystallographica Section E Structure Reports Online 61, no. 1 (2004): o102—o104. http://dx.doi.org/10.1107/s1600536804032283.

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36

Ravikumar, K., B. Sridhar, M. Mahesh, and V. V. Narayana Reddy. "A diastereoisomer of furo[3,2-c]quinoline." Acta Crystallographica Section E Structure Reports Online 61, no. 1 (2004): o195—o197. http://dx.doi.org/10.1107/s1600536804033550.

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37

Gorbunov, Yu O., V. S. Mityanov, V. G. Melekhina, and M. M. Krayushkin. "Synthesis of novel 4H-furo[3,2-c]pyran-4-ones and 4H-furo[3,2-c]chromen-4-ones." Russian Chemical Bulletin 67, no. 2 (2018): 304–7. http://dx.doi.org/10.1007/s11172-018-2074-y.

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38

Cortés, Iván, L. Javier Cala, Andrea B. J. Bracca, and Teodoro S. Kaufman. "Furo[3,2-c]coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanisms." RSC Advances 10, no. 55 (2020): 33344–77. http://dx.doi.org/10.1039/d0ra06930b.

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The isolation, synthesis and biological activity of naturally occurring furo[3,2-c] coumarins carrying carbon substituents at C-2 and/or C-3, is discussed. Synthetic approaches toward the properly functionalized heterocyclic motif are also presented.

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39

Lockhart, Christopher C., and J. Walter Sowell. "Synthesis of substituted furo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines and furo[3,2-e]tetrazolo[1,5-c]pyrimidines." Journal of Heterocyclic Chemistry 33, no. 3 (1996): 659–61. http://dx.doi.org/10.1002/jhet.5570330323.

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40

Yan, Zhimin, Yanping Wang, Junqiao Ding, Yue Wang, and Lixiang Wang. "Methoxyl modification in furo[3,2-c]pyridine-based iridium complexes towards highly efficient green- and orange-emitting electrophosphorescent devices." Journal of Materials Chemistry C 5, no. 46 (2017): 12221–27. http://dx.doi.org/10.1039/c7tc04269h.

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41

Zhou, Hui, Xinzhao Deng, Zhenjun Ma, et al. "Synthesis of furo[3,2-c]coumarin derivatives using visible-light-promoted radical alkyne insertion with bromocoumarins." Organic & Biomolecular Chemistry 14, no. 25 (2016): 6065–70. http://dx.doi.org/10.1039/c6ob00768f.

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42

Morita, Hiroyuki, and Shunsaku Shiotani. "Furopyridines. VII. Preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo[3,2-b]-, furo[2,3-c]- and furo[3,2-c]pyridine." Journal of Heterocyclic Chemistry 24, no. 2 (1987): 373–76. http://dx.doi.org/10.1002/jhet.5570240216.

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Yan, Zhimin, Yanping Wang, Jiaxiu Wang, Yue Wang, Junqiao Ding, and Lixiang Wang. "A novel furo[3,2-c]pyridine-based iridium complex for high-performance organic light-emitting diodes with over 30% external quantum efficiency." J. Mater. Chem. C 5, no. 39 (2017): 10122–25. http://dx.doi.org/10.1039/c7tc03937a.

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Listratova, Anna V., Roman S. Borisov, Nikolay Yu Polovkov, and Larisa N. Kulikova. "Synthesis and Biological Activity of Chromeno[3,2-c]Pyridines." Molecules 29, no. 21 (2024): 4997. http://dx.doi.org/10.3390/molecules29214997.

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The review summarizes all synthetic methodologies for the preparation of chromeno[3,2-c]pyridines and chromeno[3,2-c]quinolines. The proposed approaches are systemized based on ways for the construction of the heterocyclic system. The presence of these compounds in nature and their bioactivity are also discussed. Natural products with an annelated chromeno[3,2-c]pyridine fragment are well-known and a number of alkaloids derived from this system as a key core have been recently isolated. These compounds demonstrate antimicrobial, antivirus, and cytotoxic activities, making chromeno[3,2-c]pyridi

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Karkhelikar, Manjusha V., Rajeev R. Jha, B. Sridhar, Pravin R. Likhar, and Akhilesh K. Verma. "An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles." Chem. Commun. 50, no. 62 (2014): 8526–28. http://dx.doi.org/10.1039/c4cc02466d.

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SHIOTANI, S., and H. MORITA. "ChemInform Abstract: Furopyridines. Part 11. 13C NMR Spectra of 2- or 3-Substituted Furo(2, 3-b)-, Furo(3,2-b)-, Furo(2,3-c)- and Furo(3,2-c)pyridine." ChemInform 23, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199213045.

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Reissig, Hans-Ulrich, and Maurice Taszarek. "Synthesis of New Multivalent Furo[3,2-c]pyridine and Bifuro[3,2-c]pyridine Derivatives." HETEROCYCLES 104, no. 11 (2022): 2053. http://dx.doi.org/10.3987/com-22-14737.

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GOERLITZER, K., and H. BEHRJE. "ChemInform Abstract: Furo-, Pyrrolo- and Pyridazino(3,4-c)quinolines." ChemInform 27, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199648057.

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Wahyuningsih, Tutik Dwi. "SYNTHESIS OF NOVEL INDOLO[3,2-c]QUINOLINES; ETHYL 3-CHLORO-9,11-DIMETHOXY INDOLO[3,2-c]QUINOLINE-6-CARBOXYLATE." Indonesian Journal of Chemistry 5, no. 3 (2010): 189–92. http://dx.doi.org/10.22146/ijc.21786.

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-Carboline and its derivatives are significant due to their pharmacological importance. The synthesis of indolo[3,2-c]quinolines as a benzo analog of -carboline has been carried out via an oxime ether intermediate. Reaction of 2'-glyoxylic ester with hydroxylamine hydrochloride in the presence of sodium acetate afforded the oxime acetate in 82%. It was then treated with natrium and fluoro-2,4-dinitrobenzene in ethanol to give an orange solid of oxime ether acetate which is in subsequent treatment with a base yielded a pale yellow solid of indolo[3,2-c]carboline in 43%. Keywords: -carboline,

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Yamaguchi, Seiji, Keiko Orito, Noriko Shimizu, et al. "Furopyridines.XXIX. Reactions of furo[2,3-b:4,5-c‘]-, -[3,2-b:-4,5-c’]-, -[2,3-c:4,5-c‘]- and -[3,2-c:3,2-c’]dipyridine." Journal of Heterocyclic Chemistry 36, no. 1 (1999): 81–94. http://dx.doi.org/10.1002/jhet.5570360113.

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