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Journal articles on the topic 'Furoquinoline Alkaloid'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Halstead, Clynton W., Paul I. Forster, and Peter G. Waterman. "Novel Metabolites from the Stem Bark of Brombya sp. Nova (Gap Creek) (Rutaceae)." Natural Product Communications 1, no. 5 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100502.

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Two piperonyl derivatives, seven coumarins and two furoquinoline alkaloids were isolated from the aerial parts of a new species of Brombya [Brombya sp. nov. (Gap Creek) (Rutaceae)]. Three of the compounds were new natural metabolites; 7-(3,4-methylenedioxyphenyl)octene-2-one (7,8-dehydromoskachen D), the coumarin 6-(1ξ,2ξ,3-trihydroxy-3-methylbutyl)-7-hydroxy-2H-1-benzopyran-2-one, and the furoquinoline alkaloid 4,5,6,7-tetramethoxyfuro[2,3-b]quinoline (5,6,7-trimethoxydictamnine). The secondary metabolites isolated in this study are typical of the Rutaceae, contrasting with earlier studies on

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2

Magadula, Joseph J., Modest C. Kapingu, Zakaria H. Mbwambo, and Dulcie A. Mulholland. "Secondary Metabolites from Teclea amanuensis (Rutaceae) from Tanzania." Natural Product Communications 3, no. 10 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301020.

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The dichloromethane extract of the stem bark of Teclea amaniensis has yielded two novel furoquinoline alkaloids, 5-[3-methylbut-2-enyl]-4,6,7-trimethoxyfuro[2,3- b]quinoline and 6-(2′,3′-epoxy-3-methylbutyl)-5-hydroxyl-4,7-dimethoxyfuro[2,3- b]quinoline, in addition to an acridone alkaloid, 2-hydroxy-1,3-dimethoxy-10-methylacridone. Three known alkaloids, dictamnine, kokusaginine and evoxanthine, and two known triterpenoids, lupeol and lupeol acetate were also isolated. Structures of the new compounds were established by means of NMR spectroscopic and MS data.

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3

Szewczyk, Agnieszka, Monika Trepa, and Dominika Zych. "Optimization of the Production of Secondary Metabolites from Furanocoumarin and Furoquinoline Alkaloid Groups in In Vitro Ruta corsica Cultures Grown in Temporary Immersion Bioreactors." Molecules 29, no. 22 (2024): 5261. http://dx.doi.org/10.3390/molecules29225261.

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Ruta corsica is a rare and endemic plant native to Corsica. Due to its limited distribution and the priority to preserve natural sites, has been insufficiently studied. In vitro cultures provide an opportunity to research R. corsica under controlled conditions. In the present study, in vitro cultures of R. corsica were conducted in PlantformTM bioreactors. The study aimed to assess the effects of growth cycle length (5 and 6 weeks) and different concentrations of plant growth regulators (NAA and BAP) at 0.1/0.1, 0.1/0.5, 0.5/0.5, 0.5/1.0, and 1.0/1.0 mg/L on biomass growth and secondary metabo

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4

de Souza, Rejane C., João B. Fernandes, Paulo C. Vieira, et al. "A New Imidazole Alkaloid and Other Constituents from Pilocarpus grandiflorus and their Antifungal Activity." Zeitschrift für Naturforschung B 60, no. 7 (2005): 787–91. http://dx.doi.org/10.1515/znb-2005-0715.

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The stems of Pilocarpus grandiflorus have afforded the new imidazole alkaloid 4,6-dehydro- 1,2,4,5-tetrahydro-2,5-dioxopilocarpine in addition to the 17 known compounds germanicol, β - amiryn, ocotillone, stigmast-4-en-3-one, 3β -hydroxy-stigmast-5-en-7-one, 6β -hydroxy-stigmast-4- en-3-one, β -sitosterol, scopoletin, 3-(1’,1’-dimethylallyl)-scopoletin, elisin, dictamine, 4-methoxy-2- quinolone, platydesmine, syringaresinol, syringaldehyde, syringic acid and vanillic acid. Their structures were elucidated on the basis of chemical and spectroscopic evidence. The phenolic compounds vanillic acid

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5

Mohammed, Magdy M. D., and Eman R. El-Sharkawy. "Cytotoxic new furoquinoline alkaloid isolated from Ammi majus L. growing in Egypt." Natural Product Research 31, no. 6 (2016): 645–52. http://dx.doi.org/10.1080/14786419.2016.1217858.

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6

Yang, Zhong-duo, Dong-bo Zhang, Jin Ren, and Ming-jun Yang. "Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor." Medicinal Chemistry Research 21, no. 6 (2011): 722–25. http://dx.doi.org/10.1007/s00044-011-9581-9.

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7

El-Sawy, Eslam R., Ahmed B. Abdelwahab, and Gilbert Kirsch. "Maculine: a furoquinoline alkaloid from the family Rutaceae: sources, syntheses and biological activities." Arkivoc 2020, no. 7 (2020): 82–93. http://dx.doi.org/10.24820/ark.5550190.p011.200.

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8

Chang, Gwo-Jyh, Mei-Hwan Wu, Wen-Pin Chen, Sheng-Chu Kuo, and Ming-Jai Su. "Electrophysiological characteristics of antiarrhythmic potential of acrophyllidine, a furoquinoline alkaloid isolated fromAcronychia halophylla." Drug Development Research 50, no. 2 (2000): 170–85. http://dx.doi.org/10.1002/1098-2299(200006)50:2<170::aid-ddr7>3.0.co;2-w.

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9

Gokmen, Aysegul A., Hüseyin Can, Hüsniye Kayalar, Bayram Pektaş, and Selçuk Kaya. "In vitro anti-Trichomonas vaginalis activity of Haplophyllum myrtifolium." Journal of Infection in Developing Countries 13, no. 03 (2019): 240–44. http://dx.doi.org/10.3855/jidc.10854.

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Introduction: In the classic treatment of Trichomonas vaginalis infection, although metronidazole has been used since the 1960s, there has been an increase in MTZ-resistant T. vaginalis strains and failure in the treatment of trichomoniasis causes serious concerns. Therefore, the present study aimed to investigate the in vitro antitrichomonal activities of extracts (ethanol and total alkaloid) and pure compounds (chrysosplenetin, dictamnine, gamma-Fagarine, skimmianine) of H. myrtifolium against T. vaginalis. Methodology: H. myrtifolium was collected from the town of Honaz in Denizli, lo

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10

Kuete, Victor, Hugues Fouotsa, Armelle T. Mbaveng, Benjamin Wiench, Augustin E. Nkengfack, and Thomas Efferth. "Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells." Phytomedicine 22, no. 10 (2015): 946–51. http://dx.doi.org/10.1016/j.phymed.2015.07.002.

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11

Tesfaye, Nuru, Girmay Solomon, Melaku Yadessa, and Endale Milkyas. "Benzoylbetulin from Roots of Teclea nobilis." Pharmaceutical and Chemical Journal 5, no. 4 (2018): 56–62. https://doi.org/10.5281/zenodo.13921354.

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<em>Teclea nobilis</em> is widely distributed in tropical Africa and used as the remedy for gonorrhea, fever and analgesics. The roots of <em>Teclea nobilis</em> were exhaustively extracted using dichloromethane/methanol (1:1) and methanol to give 2.36% and 2.12% yield, respectively. Phytochemical screening analysis conducted on roots extracts of <em>Teclea nobilis</em> revealed the presence of alkaloid, tannins, flavonoids, steroids and saponins. Silica gel column chromatographic separation of the crude extract afforded benzoylbetulin (3), isolated for the first time from natural source, alon

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12

Ribeiro, Victor Pena, Joanna Bajsa-Hirschel, Prabin Tamang, Kumudini Meepagala, and Stephen O. Duke. "Antifungal and Phytotoxic Activities of Isolated Compounds from Helietta parvifolia Stems." Molecules 28, no. 23 (2023): 7930. http://dx.doi.org/10.3390/molecules28237930.

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The identification of natural and environmentally friendly pesticides is a key area of interest for the agrochemical industry, with many potentially active compounds being sourced from numerous plant species. In this study, we report the bioassay-guided isolation and identification of phytotoxic and antifungal compounds from the ethyl acetate extract of Helietta parvifolia stems. We identified eight compounds, consisting of two coumarins and six alkaloids. Among these, a new alkaloid, 2-hydroxy-3,6,7-trimethoxyquinoline-4-carbaldehyde (6), was elucidated, along with seven known compounds. The

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13

Schempp, Christoph, Birgit Simon-Haarhaus, Richard Krieger, and Jan Simon. "Solar Simulator-Induced Phototoxicity of the Furoquinoline Alkaloid Dictamnine Compared to 8-Methoxypsoralen and 5-Methoxypsoralen." Planta Medica 72, no. 10 (2006): 941–43. http://dx.doi.org/10.1055/s-2006-947166.

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14

Nouga, Achille B., Jean C. Ndom, Emmanuel M. Mpondo, et al. "New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves ofOricia suaveolens and Oricia renieri(Rutaceae)." Natural Product Research 30, no. 3 (2015): 305–10. http://dx.doi.org/10.1080/14786419.2015.1057727.

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15

Couillerot, Eric, Catherine Caron, Jean Claude Audran, Jean Claude Jardillier, and Jean Claude Ch�nieux. "Furoquinoline alkaloid accumulation in Fagara zanthoxyloides cell cultures is highly dependent on the presence of exogenous benzylaminopurine." Plant Growth Regulation 19, no. 3 (1996): 203–6. http://dx.doi.org/10.1007/bf00037792.

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16

Zhu, Si-Si, Yi-Fan Zhang, Meng Ding, Ke-Wu Zeng, Peng-Fei Tu, and Yong Jiang. "Anti-Neuroinflammatory Components from Clausena lenis Drake." Molecules 27, no. 6 (2022): 1971. http://dx.doi.org/10.3390/molecules27061971.

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Clausena lenis Drake (C. lenis) is a folk medicinal herb to treat influenza, colds, bronchitis, and malaria. The 95% and 50% ethanol extract of C. lenis showed significant nitric oxide (NO) inhibition activity in BV-2 microglial cells stimulated by lipopolysaccharide (LPS). Bio-guided isolation of the active extract afforded five new compounds, including a chlorine-containing furoquinoline racemate, (±)-claulenine A (1), an amide alkaloid, claulenine B (2), a prenylated coumarin, claulenin A (3), a furocoumarin glucoside, clauleside A (4), and a multi-prenylated p-hydroxybenzaldehyde, clauleni

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17

Su, Ming-Jai, Gwo-Jyh Chang, Mei-Hwan Wu, and Sheng-Chu Kuo. "Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart." British Journal of Pharmacology 122, no. 7 (1997): 1285–98. http://dx.doi.org/10.1038/sj.bjp.0701510.

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18

Fu, Yudong, Yujie Deng, Qing Yu, et al. "Identification of In Vivo Metabolites of Dictamnine in Mice Using HPLC-LTQ-Orbitrap Mass Spectrometry." Journal of Analytical Methods in Chemistry 2018 (December 18, 2018): 1–7. http://dx.doi.org/10.1155/2018/3567647.

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Dictamnine (4-methoxyfuro[2,3-b]quinolone, DIC), a common furoquinoline alkaloid in the family of Rutaceae, showed diverse biological activities. To investigate the in vivo metabolic pathways of DIC, metabolism of DIC in mice was studied using a high-performance liquid chromatography coupled to electrospray ionization of hybrid linear trap quadrupole orbitrap (HPLC-LTQ-Orbitrap) mass spectrometer. Nine metabolites were identified in the DIC-treated mouse urine, plasma, and fecal samples, of which two were identified as new metabolites. The major metabolic pathways of DIC in animal and human li

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19

Chang, A., and U. Eilert. "A First Specific Enzyme of Furoquinoline Alkaloid Biosynthesis:S-Adenosyl-L-methionine: 4-Hydroxy-3-(3-methyl-2-butenyl)-2-quinolinoneO-Methyltransferase." Planta Medica 59, S 1 (1993): A585. http://dx.doi.org/10.1055/s-2006-959784.

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20

Schimmer, Oskar, та Ulrike Leimeister. "The SCE-inducing potency of the furoquinoline alkaloid, γ-fagarine, and a γ-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes". Mutagenesis 4, № 6 (1989): 467–70. http://dx.doi.org/10.1093/mutage/4.6.467.

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21

Ogunrinade, Folashade A., Victoria U. Iwuanyanwu, Satyajit D. Sarker, and Olumayokun A. Olajide. "Neuroprotection by Skimmianine in Lipopolysaccharide-Activated BV-2 Microglia." Molecules 28, no. 3 (2023): 1317. http://dx.doi.org/10.3390/molecules28031317.

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Skimmianine is a furoquinoline alkaloid which is found in the Zanthoxylum genus and also in other plants of the Rutaceae family. This study evaluated the effects of skimmianine on the production of pro-inflammatory mediators in LPS-activated BV-2 microglia. Cultured BV-2 cells were treated with skimmianine (10, 20 and 30 μM), followed by stimulation with LPS (100 ng/mL). Levels of TNFα and IL-6 in cell supernatants were measured using ELISA, while NO and PGE2 levels were evaluated with Griess assay and EIA, respectively. Western blotting was used to determine the protein expression of iNOS, CO

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22

Wong, Puiian, Zheng Lv, Jinglan Li та ін. "A Novel RANKL-Targeted Furoquinoline Alkaloid Ameliorates Bone Loss in Ovariectomized Osteoporosis through Inhibiting the NF-κB Signal Pathway and Reducing Reactive Oxygen Species". Oxidative Medicine and Cellular Longevity 2022 (4 листопада 2022): 1–15. http://dx.doi.org/10.1155/2022/5982014.

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Dysregulation of osteoclast-osteoblast balance, resulting in abnormal bone remodeling, is responsible for postmenopausal osteoporosis (PMOP) or other secondary forms of osteoporosis. We demonstrated that dictamnine (DIC), a novel RANKL-targeted furoquinoline alkaloid, inhibits osteoclastogenesis by facilitating the activities of reactive oxygen species (ROS), NF-κB, and NFATc1 in vitro and prevents the development of OVX-induced osteoporosis mouse models in vivo. Methods. The docking mechanism of DIC and RANKL was initially identified by protein–ligand molecular docking. RNA sequencing was per

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23

Szewczyk, Agnieszka, and Filip Pęczek. "Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties." International Journal of Molecular Sciences 24, no. 16 (2023): 12811. http://dx.doi.org/10.3390/ijms241612811.

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Furoquinoline alkaloids exhibit a diverse range of effects, making them potential candidates for medicinal applications. Several compounds within this group have demonstrated antimicrobial and antiprotozoal properties. Of great interest is their potential as acetylcholinesterase inhibitors and anti-inflammatory agents in neurodegenerative diseases. The promising biological properties of furoquinoline alkaloids have motivated extensive research in this field. As a result, new compounds have been isolated from this group of secondary metabolites, and numerous pharmacological studies have been co

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24

Gomes, Elsa, Sébastien Travert, Jacqueline Gleye, Claude Moulis, Isabelle Fourasté, and Eduoard Stanislas. "Furoquinoline Alkaloids fromVepris heterophylla." Planta Medica 60, no. 04 (1994): 388. http://dx.doi.org/10.1055/s-2006-959512.

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25

Al-Rehaily, Adnan J., Mohammad S. Ahmad, Ilias Muhammad, Assad A. Al-Thukair, and Herman P. Perzanowski. "Furoquinoline alkaloids from Teclea nobilis." Phytochemistry 64, no. 8 (2003): 1405–11. http://dx.doi.org/10.1016/j.phytochem.2003.09.013.

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26

Sun, Jianbo, Neng Jiang, Mengying Lv, et al. "Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius." RSC Advances 6, no. 27 (2016): 22550–54. http://dx.doi.org/10.1039/c5ra26460j.

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27

Szewczyk, Agnieszka, Mariusz Grabowski, and Dominika Zych. "Ruta chalepensis L. In Vitro Cultures as a Source of Bioactive Furanocoumarins and Furoquinoline Alkaloids." Life 13, no. 2 (2023): 457. http://dx.doi.org/10.3390/life13020457.

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Recently, due to the decreasing areas of cultivation and climate change, the use of biotechnological methods to obtain biomass, which is a source of valuable bioactive metabolites, is becoming more and more interesting. In this study, Ruta chalepensis in vitro cultures were investigated in RITA® temporary immersion bioreactors. Biomass growth and the production of secondary metabolites in 4- and 5-week growth cycles on three variants of the Linsmaier and Skoog (LS) medium (naphthyl-1-acetic acid/6-benzylaminopurine (NAA/BAP): 0.5/1.0, 0.1/0.1, and 1.0/1.0 mg/L) were analyzed. Using high-perfor

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28

Bhoga, Umadevi, R. S. Mali, and Srinivas R. Adapa. "New synthesis of linear furoquinoline alkaloids." Tetrahedron Letters 45, no. 51 (2004): 9483–85. http://dx.doi.org/10.1016/j.tetlet.2004.09.041.

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29

Komala, Ismiarni, Mawardi Rahmani, Mohd Aspollah Sukari, Hazar Bebe Mohd Ismail, Gwendoline Ee Cheng Lian, and Asmah Rahmat. "Furoquinoline alkaloids fromMelicope bonwickii(F.Muell.) T.Hartley." Natural Product Research 20, no. 4 (2006): 355–60. http://dx.doi.org/10.1080/14786410500462983.

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30

Lv, Mengying, Yuan Tian, Zunjian Zhang, Jingyu Liang, Fengguo Xu, and Jianbo Sun. "Plant metabolomics driven chemical and biological comparison of the root bark of Dictamnus dasycarpus and Dictamnus angustifolius." RSC Advances 5, no. 20 (2015): 15700–15708. http://dx.doi.org/10.1039/c5ra00115c.

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The chemical and biological differences between Dictamnus dasycarpus and Dictamnus angustifolius have been compared in this study. Among all chemical markers, furoquinoline alkaloids may play a major role in the bioactivities of these two plants.

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31

Li, Shuo-Guo, Hai-Yan Tian, Wei-Cai Ye, and Ren-Wang Jiang. "Benzopyrans and furoquinoline alkaloids from Melicope pteleifolia." Biochemical Systematics and Ecology 39, no. 1 (2011): 64–67. http://dx.doi.org/10.1016/j.bse.2011.01.005.

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32

Schimmer, Oskar, and Irmgard Kühne. "Furoquinoline alkaloids as photosensitizers in Chlamydomonas reinhardtii." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 249, no. 1 (1991): 105–10. http://dx.doi.org/10.1016/0027-5107(91)90136-c.

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33

Kang, Sam Sik, and Won Sick Woo. "Furoquinoline alkaloids from the leaves ofMelicope confusa." Archives of Pharmacal Research 9, no. 1 (1986): 11–13. http://dx.doi.org/10.1007/bf02857699.

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34

Rios, María Yolanda, and Guillermo Delgado. "Terpenoids and Alkaloids from Esenbeckia belizencis. Spontaneous Oxidation of Furoquinoline Alkaloids." Journal of Natural Products 55, no. 9 (1992): 1307–9. http://dx.doi.org/10.1021/np50087a020.

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35

Samad, Abdul, Muhammad Adeel, Dilfaraz Khan, et al. "Two New Bioactive Furoquinoline Alkaloids from Zanthoxylum armatum." Asian Journal of Chemistry 27, no. 7 (2015): 2468–72. http://dx.doi.org/10.14233/ajchem.2015.17931.

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36

Li, Yixuan, Weihua Zhang, Tingting Yin, et al. "Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids." Xenobiotica 50, no. 10 (2020): 1170–79. http://dx.doi.org/10.1080/00498254.2020.1760400.

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37

Wahjoedi, Ryan Ayub, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie, and Mulyadi Tandjung. "Melicope moluccana Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana." Journal of Tropical Pharmacy and Chemistry 5, no. 2 (2020): 138–42. http://dx.doi.org/10.25026/jtpc.v5i2.260.

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Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.

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38

Tarus, Paul K., Philip H. Coombes, Neil R. Crouch, Dulcie A. Mulholland, and B. Moodley. "Furoquinoline alkaloids from the southern African Rutaceae Teclea natalensis." Phytochemistry 66, no. 6 (2005): 703–6. http://dx.doi.org/10.1016/j.phytochem.2004.12.023.

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39

Rios, María Yolanda, A. Berenice Aguilar-Guadarrama, and Guillermo Delgado. "Furoquinoline alkaloids, furocoumarins and terpenes from Esenbeckia litoralis (Rutaceae)." Biochemical Systematics and Ecology 30, no. 10 (2002): 977–79. http://dx.doi.org/10.1016/s0305-1978(02)00042-x.

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40

de Jesus Freitas, C. M., A. M. Lucchese, F. S. Silva, and E. da S. Velozo. "Coumarins, furoquinoline alkaloids and terpenes from Spiranthera odoratissima (Rutaceae)." Biochemical Systematics and Ecology 31, no. 7 (2003): 805–7. http://dx.doi.org/10.1016/s0305-1978(03)00039-5.

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41

Sichaem, Jirapast, Apapond Jirasirichote, Krittakorn Sapasuntikul, et al. "New furoquinoline alkaloids from the leaves of Evodia lepta." Fitoterapia 92 (January 2014): 270–73. http://dx.doi.org/10.1016/j.fitote.2013.12.002.

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42

Inada, Akira, Rie Ogasawara, Iwao Koga, et al. "Three New Furoquinoline Alkaloids from the Leaves of Boninia glabra." CHEMICAL & PHARMACEUTICAL BULLETIN 56, no. 5 (2008): 727–29. http://dx.doi.org/10.1248/cpb.56.727.

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43

Chlouchi, Amina, Corinne Girard, François Tillequin, Françoise Bévalot, Peter G. Waterman, and Frédéric Muyard. "Coumarins and furoquinoline alkaloids from Philotheca deserti var. deserti (Rutaceae)." Biochemical Systematics and Ecology 34, no. 1 (2006): 71–74. http://dx.doi.org/10.1016/j.bse.2005.07.002.

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44

Kiplimo, Joyce J., Md Shahidul Islam, and Neil A. Koorbanally. "A Novel Flavonoid and Furoquinoline Alkaloids from Vepris glomerata and their Antioxidant Activity." Natural Product Communications 6, no. 12 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601215.

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The dichloromethane extract of the aerial part of the plant Vepris glomerata (Rutaceae) yielded a new flavonoid, which was accorded the trivial name veprisinol (1), together with four known furoquinoline alkaloids: haplopine-3,3′-dimethylallyl ether (2), anhydroevoxine (3), evoxine (4) and skimmianine (5). The structures of the compounds were established by 1D and 2D NMR spectroscopy, as well as HREIMS. Compounds 1 and 2 have strong antioxidant potential, similar to and in some instances better than ascorbic acid and can be used as beneficial additives to antioxidant supplements.

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45

Wansi, Jean Duplex, M. Ahmed Mesaik, David Dako Chiozem, et al. "Oxidative Burst Inhibitory and Cytotoxic Indoloquinazoline and Furoquinoline Alkaloids fromOricia suaveolens." Journal of Natural Products 71, no. 11 (2008): 1942–45. http://dx.doi.org/10.1021/np800276f.

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46

Ikuta, Akira, Takayuki Nakamura, and Hisao Urabe. "Indolopyridoquinazoline, furoquinoline and canthinone type alkaloids from Phellodendron amurense callus tissues." Phytochemistry 48, no. 2 (1998): 285–91. http://dx.doi.org/10.1016/s0031-9422(97)01130-8.

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47

Mohammed, Magdy M. D., Nabaweya A. Ibrahim, Fatma S. El-Sakhawy, Khaled M. Mohamed, and Doaa A. H. Deabes. "Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa." Natural Product Research 30, no. 22 (2016): 2559–66. http://dx.doi.org/10.1080/14786419.2015.1126262.

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48

Basco, L. K., S. Mitaku, A. L. Skaltsounis, et al. "In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 38, no. 5 (1994): 1169–71. http://dx.doi.org/10.1128/aac.38.5.1169.

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Sichaem, Jirapast, Thanawan Rojpitikul, Pattara Sawasdee, Kiattisak Lugsanangarm, and Santi Tip-Pyang. "Furoquinoline Alkaloids from the Leaves of Evodia Lepta as Potential Cholinesterase Inhibitors and their Molecular Docking." Natural Product Communications 10, no. 8 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000811.

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Abstract:

Nine furoquinoline alkaloids (1–9) were isolated from the leaves of Evodia lepta based on bioassay-guided fractionation and chromatographic techniques. All isolates were evaluated for their cholinesterase (ChEs) inhibitory activities, in which kokusaginine (7) and melineurine (5) exhibited the highest activity toward AChE and BChE, respectively. Lineweaver- Burk plots indicated that 5 and 7 were mixed mode inhibitors of both ChE enzymes. Molecular docking studies on the binding sites of AChE and BChE were performed in order to afford a molecular insight into the mode of action of these active

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Kouam, Ariane, Achille Bissoue, Alain Tcho, et al. "Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)." Molecules 23, no. 1 (2017): 13. http://dx.doi.org/10.3390/molecules23010013.

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