Relevant bibliographies by topics / Fused Benzimidazoles

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Fused Benzimidazoles'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Fused Benzimidazoles"

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Sweeney, Martin, Darren Conboy, Styliana I. Mirallai, and Fawaz Aldabbagh. "Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles." Molecules 26, no. 9 (2021): 2684. http://dx.doi.org/10.3390/molecules26092684.

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This review article provides a perspective on the synthesis of alicyclic and heterocyclic ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles, and imidazo[5,4-f]benzimidazoles. These heterocycles have a plethora of biological activities with the iminoquinone and quinone derivatives displaying potent bioreductive antitumor activity. Synthesis is categorized according to the cyclization reaction and mechanisms are detailed. Nitrobenzene reduction, cyclization of aryl amidines, lactams and isothiocyanates are described. Protocols include condensation, cross-dehydrogenative coupling with trans
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Kumar, Sushil, Maneesha D. Sati, and S. C. Sati. "Synthesis And Biological Evaluation Of Benzimidazole Derivatives." IOSR Journal of Applied Chemistry 17, no. 12 (2024): 13–18. https://doi.org/10.9790/5736-1712011318.

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Benzimidazoles are a class of heterocyclic compounds in which a benzene ring is fused to the 4 and 5 positions of an imidazole ring. Benzimidazole refers to the parent compound, while benzimidazoles are a class of heterocyclic compounds having similar ring structures, but different substituents. Benzimidazole derivatives possess a wide range of bioactivities including antimicrobial, anthelmintic, antiviral, anticancer, and antihypertensive activities. Many compounds possessing a benzimidazole skeleton have been employed as drugs in the market. The application of benzimidazoles in other fields
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Stibrany, Robert T., and Joseph A. Potenza. "rac-Dichlorido[3-ethoxy-3-(1-ethyl-1H-benzimidazol-2-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole]copper(II)." Acta Crystallographica Section E Structure Reports Online 69, no. 2 (2013): m92—m93. http://dx.doi.org/10.1107/s1600536812051641.

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The title complex, [CuCl2(C21H22N4O)], contains a bis(benzimidazole) unit with a chiral bridgehead C atom that forms part of a tetrahydropyrrole ring fused to one of the benzimidazoles. The chelate angle is 90.45 (9)° and the dihedral angle between the essentially planar benzimidazole fragments is 26.68 (9)°. The CuIIcoordination geometry lies approximately midway between tetrahedral and square planar. Overall, each chiral molecule contains six fused rings, and a racemic mixture is formed with symmetry-related enantiomers. In the crystal, C—H...π and C—H...Cl interactions link molecules into a
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H., E. MASTER, and R. KAMATH J. "Preparation of Newer Fused Benzimidazoles." Journal of Indian Chemical Society Vol. 72, Sep 1995 (1995): 645–46. https://doi.org/10.5281/zenodo.5909671.

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Nadkamy-Sacasa Research Laboratory, St Xavier&#39;s College, Bombay-400 001 <em>Manuscript received 3 August 1993, revised 27 January 1994, accepted 8 February 1994</em> Preparation of Newer Fused Benzimidazoles.
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Bansal, Yogita, Manjinder Kaur, and Gulshan Bansal. "Antimicrobial Potential of Benzimidazole Derived Molecules." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 624–46. http://dx.doi.org/10.2174/1389557517666171101104024.

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Structural resemblance of benzimidazole nucleus with purine nucleus in nucleotides makes benzimidazole derivatives attractive ligands to interact with biopolymers of a living system. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. This structural similarity prompted medicinal chemists across the globe to synthesize a variety of benzimidazole derivatives and to screen those for various biological activities, such as anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, a
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Kapoor, Kamal, Parthasarathi Das, Rajni Khajuria, Sk Rasheed, and Chhavi Khajuria. "Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles." Synthesis 50, no. 11 (2018): 2131–49. http://dx.doi.org/10.1055/s-0036-1589533.

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Pyrido[1,2-a]benzimidazole is one of the most important azaheterocyclic compounds consisting of three fused aromatic rings. Molecules containing this core have displayed a wide range of applications in the field of medicinal chemistry. The synthesis of pyrido[1,2-a]benzimidazole and its derivatives has attracted organic chemists because of its tremendous utility in interdisciplinary branches of chemistry. In this context, this review discusses the main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016.1 Introduction2 Syntheti
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Sonawane, Amol D., Rohini A. Sonawane, Khin Myat Noe Win, Masayuki Ninomiya, and Mamoru Koketsu. "In situ air oxidation and photophysical studies of isoquinoline-fused N-heteroacenes." Organic & Biomolecular Chemistry 18, no. 11 (2020): 2129–38. http://dx.doi.org/10.1039/d0ob00375a.

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MASTER, H. E., and J. R. KAMATH. "ChemInform Abstract: Preparation of Newer Fused Benzimidazoles." ChemInform 27, no. 50 (2010): no. http://dx.doi.org/10.1002/chin.199650172.

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Qin, Hui, Yuanyuan Miao, Jian Xu, et al. "A facile and efficient [4 + 2] annulation reaction of sulfur ylides: access to N-fused benzimidazoles." Organic Chemistry Frontiers 6, no. 2 (2019): 205–8. http://dx.doi.org/10.1039/c8qo01133h.

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Nguyen, T. B., L. Ermolenko, and A. Al-Mourabit. "Formic acid as a sustainable and complementary reductant: an approach to fused benzimidazoles by molecular iodine-catalyzed reductive redox cyclization of o-nitro-t-anilines." Green Chemistry 18, no. 10 (2016): 2966–70. http://dx.doi.org/10.1039/c6gc00902f.

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Dissertations / Theses on the topic "Fused Benzimidazoles"

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洪懿慈. "Discovery of Novel RAD 51 and NF-kB Inhibitors : IBR2 Analogues and Aminofuran fused Benzimidazole and Synthesis of Phosphonyl Pyrazole fused Benzimidazole." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/9dfyeg.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>100<br>In this thesis, we used multicomponent reactions for synthesis of different main architecture of small organic molecules and did the biological screening for anticancer activity, in order to identify the high inhibition of drug leads. This thesis can be divided into three parts: The first part reported the improvement of the synthetic approach for the assembling of IBR2 analogues. The original two steps synthetic route was improved to one pot tandem reaction and the reaction time was reduced to 30 minutes from 20 hours. Based on this efficient synthetic appr
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Book chapters on the topic "Fused Benzimidazoles"

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Borpatra, Paran Jyoti, and Mintu Maan Dutta. "Bioactive Five-Membered Heterocycles With Two Heteroatoms Fused With a Benzene Ring (a) Benzimidazole." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch007.

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Heterocyclic compounds play a crucial role in medicinal chemistry, serving as key components in the development of pharmacologically active molecules. The therapeutic promise of many synthesized drugs can be attributed to their heterocyclic scaffolds, wherein even minor modifications in the heterocyclic structure can significantly impact the drug's efficacy. Among these, benzimidazoles are particularly significant. These class of compounds comprises a combination of the aromatic benzene ring and an imidazole ring. A significant natural form of benzimidazole found in nature is N-ribosyl-dimethy
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Dharma Rao, G. B., Bentham Science Publisher Versha, and Anjaneyulu Bendi. "Imidazole and Benzimidazole Derivatives as Anti-Inflammatory Agents." In Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223460124010006.

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In current days, imidazoles and benzimidazoles are vital classes of Nheterocyclic compounds. One of the 5-membered heterocyclic compounds is imidazole ring structure through 3 carbon and 2 nitrogen atoms and in imidazole structure, N is occupied in 1st and 3rd location in five-membered ring system. It is planer in structure. The imidazole moiety is an essential of numerous significant natural products, together with histamine, purine, histidine and nucleic acid. On the other hand, benzimidazole covers six-membered benzene ring system fused with five-member imidazole ring systems. Benzimidazole
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Thatikayala, Mahender, Anil Kumar Garige, and Hemalatha Gadegoni. "Benzimidazole: Pharmacological Profile." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102091.

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Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. Benzimidazole holds a vital role in the field of medicinal chemistry which possesses wide variety of pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, anti tubercular, anti viral and anti malarial respectively, hence the benzimidazole moiety attracting the medicinal chemist to synthesize the different benzimidazole derivatives with wide variety of pharmacological activities. The book chapter mainly discussed the anti cancer, anti HIV, antileishmanial and
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Kavya, Gopakumar, and Akhil Sivan. "Exploring the Versatility of Benzimidazole Scaffolds as Medicinal Agents: A Brief Update." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101942.

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Benzimidazole, one of the finest classes of heterocyclic aromatic compounds have the characteristic structure of benzene fused with a five-membered imidazole ring. Despite being made their first appearance in the late 1870s, they are considered as a ‘privileged molecule’. The applications of this wonder molecule range from medicinal chemistry to material science. Benzimidazole being a potent inhibitor for various enzymes has got therapeutic effects like anticancer, antimicrobial, anthelmintic, antioxidant, anticonvulsant, antifungal, anti-inflammatory, antiviral, antihistaminic, antipsychotic,
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Conference papers on the topic "Fused Benzimidazoles"

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Anichina, K. "SYNTHESIS AND ANTINEMATODAL ACTIVITY STUDIES OF SOME FUSED TRIAZINOBENZIMIDAZOLES." In International Trends in Science and Technology. RS Global Sp. z O.O., 2020. http://dx.doi.org/10.31435/rsglobal_conf/30122020/7351.

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4-Aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines 3a-f were synthesized in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatilebenzaldehydes. Structures of all prepared compounds were confirmed by IR, 1H NMR spectroscopyand elemental analysis.Antinematodal activity in vitro of the substances was investigated using isolated Trichinella spiralis muscle larvae. The tested triazonobenzimidazoles showed different activity depending on the substituent R in their moleculeas the derivatives substituted with a hydroxyl group demonstrated the best anti-Trichinell
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