Relevant bibliographies by topics / Fused imidazoles

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Fused imidazoles'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Fused imidazoles"

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Aly, Ashraf A. "Base Catalyzed Synthesis of Novel Fused-Imidazoles from N-Vinyl-1H-imidazole." Zeitschrift für Naturforschung B 60, no. 1 (2005): 106–12. http://dx.doi.org/10.1515/znb-2005-0116.

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Syntheses of various classes of fused-imidazoles are reported. The key to their successful synthesis depends on the reaction of N-vinyl-1H-imidazole with the π-deficient compounds under basic conditions. Reaction of the target imidazole with 1,1,2,2-tetracyanoethylene and dimethyl acetylenedicarboxylate afforded pyrrolo[1,2-a]imidazoles. On the other site, reaction of the target imidazole with 2-dicyanomethyleneindane-1,3-dione, 2,3-dicyano-1,4-naphthoquinone gave indanylimidazolo- [1,2-a]azepine and imidazolo[2,1-a]phenanthridine derivatives, respectively. Under basic reaction condition, vari
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2

Frippiat, Steven, Christine Baudequin, Christophe Hoarau, et al. "Pd(0)-Catalyzed Direct Inter- and Intramolecular C–H Functionalization of 4-Carboxyimidazoles." Synlett 31, no. 10 (2020): 1015–21. http://dx.doi.org/10.1055/s-0040-1708003.

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The palladium-catalyzed arylation and alkenylation of N-substituted methyl imidazole-4-carboxylates are described through inter- and intramolecular pathways. Both direct C2–H and C5–H arylation and alkenylation proceed under Pd(0)/Cu(I) cooperative catalysis and Pd(0) catalysis, respectively, in low-polarity 1,4-dioxane solvent. The methodology gives access to C2 (hetero)aryl or alkenyl imidazoles as well as innovative C2- and C5-arylated fused imidazoles tricycles with a five- to seven-membered middle ring.
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3

Kwak, Jung Pyo, Pham Duy Quang Dao, Nam Sik Yoon, and Chan Sik Cho. "Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks." RSC Advances 11, no. 35 (2021): 21367–74. http://dx.doi.org/10.1039/d1ra04396j.

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A green synthesis of trinuclear imidazole-fused hybrid scaffolds has been developed by transition metal-free double C(sp<sup>2</sup>)–N coupling and cyclization of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks under microwave irradiation.
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Gupta, Vijay, Satish K. Pandey, and Ravi P. Singh. "Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics." Organic & Biomolecular Chemistry 16, no. 39 (2018): 7134–38. http://dx.doi.org/10.1039/c8ob01930d.

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Potikha, Lyudmyla, Volodymyr Kovtunenko, Arsen Turelyk, Aleksandr Turov, and Andrei Tolmachev. "Synthesis of Fused Pyrido[ a ]imidazoles." Synthetic Communications 38, no. 12 (2008): 2061–70. http://dx.doi.org/10.1080/00397910801997868.

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6

Patel, Alpa, Swee Y. Sharp, Katelan Hall, et al. "Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines." Organic & Biomolecular Chemistry 14, no. 16 (2016): 3889–905. http://dx.doi.org/10.1039/c6ob00471g.

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7

Abel, Steven-Alan G., Mathew O. Eglinton, James K. Howard, Dylan J. Hunt, Rolf H. Prager, and Jason A. Smith. "Synthesis of Heterocyclic-fused Imidazoles by Pyrolysis of N-Heterocyclic Isoxazol-5(2H)-ones." Australian Journal of Chemistry 67, no. 9 (2014): 1228. http://dx.doi.org/10.1071/ch14119.

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The synthesis of heterocyclic-fused imidazoles was achieved by flash vacuum pyrolysis (FVP) of N-heterocyclic isoxazol-5(2H)-ones via an iminocarbene intermediate. Unlike iminocarbenes generated from triazoles, no structural rearrangements were observed during the current synthesis method. We also demonstrated that less volatile isoxazol-5(2H)-one derivatives yield the corresponding imidazoles by condensed phase pyrolysis.
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8

Sharma, Pankaj, Chris LaRosa, Janet Antwi, Rajgopal Govindarajan, and Karl A. Werbovetz. "Imidazoles as Potential Anticancer Agents: An Update on Recent Studies." Molecules 26, no. 14 (2021): 4213. http://dx.doi.org/10.3390/molecules26144213.

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Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide range of bioactive compounds. The unique properties of such structures, including high polarity and the ability to participate in hydrogen bonding and coordination chemistry, allow them to interact with a wide range of biomolecules, and imidazole-/fused imidazole-containing compounds are reported to have a broad spectrum of biological activities. This review summarizes recent reports of imidazole/fused imidazole derivatives a
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9

Kavina, M. A., V. V. Sizov, and I. P. Yakovlev. "Fused Imidazoles: I. Synthesis of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole Derivatives." Russian Journal of Organic Chemistry 54, no. 6 (2018): 901–11. http://dx.doi.org/10.1134/s107042801806012x.

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10

Singh, Davinder, Javeed Ahmad Tali, Gulshan Kumar, and Ravi Shankar. "Metal-free oxidative decarbonylative halogenation of fused imidazoles." New Journal of Chemistry 45, no. 44 (2021): 20551–55. http://dx.doi.org/10.1039/d1nj04440k.

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Dissertations / Theses on the topic "Fused imidazoles"

1

Rickwood, Martin. "Synthesis and reactivity of bridgehead [1,5]-fused imidazoles." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/14280.

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Moody, David John. "Studies of some fused imidazole derivatives." Thesis, University of St Andrews, 1986. http://hdl.handle.net/10023/11011.

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The main synthetic routes to benzimidazole N-oxides are outlined and some indication is given as to the current and potential pharmacological usefulness of such materials. A claim that 4-methyl-2-nitrophenylglycine is cyclised in acetic anhydride to give either 5-methylbenzimidazole 3-oxide or the isomeric 5 methylbenzimidazolone was investigated. This work was found to be impossible to duplicate. It is established that, by employing flash vacuum pyrolysis, the claimed products can be obtained thermolytically from the starting glycine. This is the first recorded example of the formation of an
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Book chapters on the topic "Fused imidazoles"

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Dharma Rao, G. B., Bentham Science Publisher Versha, and Anjaneyulu Bendi. "Imidazole and Benzimidazole Derivatives as Anti-Inflammatory Agents." In Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223460124010006.

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In current days, imidazoles and benzimidazoles are vital classes of Nheterocyclic compounds. One of the 5-membered heterocyclic compounds is imidazole ring structure through 3 carbon and 2 nitrogen atoms and in imidazole structure, N is occupied in 1st and 3rd location in five-membered ring system. It is planer in structure. The imidazole moiety is an essential of numerous significant natural products, together with histamine, purine, histidine and nucleic acid. On the other hand, benzimidazole covers six-membered benzene ring system fused with five-member imidazole ring systems. Benzimidazole
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2

Chandrashekharappa, Sandeep, Subrata Barick, and Kaustav Dhara. "Biological Relevance of Five Membered Fused Heterocycle Imidazothiazole." In Advances in Bioinformatics and Biomedical Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7520-4.ch001.

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Heterocyclic compounds are essential in the metabolism of all living cells, and most nitrogen-containing fused heterocyclic compounds with five-membered rings are biologically active. Nitrogen and sulphur-containing heteroaromatic compounds, such as imidazothiazoles and their derivatives, are acknowledged for their biological activity and substantial contributions to medicinal chemistry. Imidazothiazoles are defined by their fused bicyclic structure, merging an imidazole ring (a five-membered ring with two non-adjacent nitrogen atoms) with a thiazole ring (a five-membered ring containing both
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3

Thatikayala, Mahender, Anil Kumar Garige, and Hemalatha Gadegoni. "Benzimidazole: Pharmacological Profile." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102091.

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Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. Benzimidazole holds a vital role in the field of medicinal chemistry which possesses wide variety of pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, anti tubercular, anti viral and anti malarial respectively, hence the benzimidazole moiety attracting the medicinal chemist to synthesize the different benzimidazole derivatives with wide variety of pharmacological activities. The book chapter mainly discussed the anti cancer, anti HIV, antileishmanial and
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4

Kavya, Gopakumar, and Akhil Sivan. "Exploring the Versatility of Benzimidazole Scaffolds as Medicinal Agents: A Brief Update." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101942.

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Benzimidazole, one of the finest classes of heterocyclic aromatic compounds have the characteristic structure of benzene fused with a five-membered imidazole ring. Despite being made their first appearance in the late 1870s, they are considered as a ‘privileged molecule’. The applications of this wonder molecule range from medicinal chemistry to material science. Benzimidazole being a potent inhibitor for various enzymes has got therapeutic effects like anticancer, antimicrobial, anthelmintic, antioxidant, anticonvulsant, antifungal, anti-inflammatory, antiviral, antihistaminic, antipsychotic,
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Borpatra, Paran Jyoti, and Mintu Maan Dutta. "Bioactive Five-Membered Heterocycles With Two Heteroatoms Fused With a Benzene Ring (a) Benzimidazole." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch007.

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Heterocyclic compounds play a crucial role in medicinal chemistry, serving as key components in the development of pharmacologically active molecules. The therapeutic promise of many synthesized drugs can be attributed to their heterocyclic scaffolds, wherein even minor modifications in the heterocyclic structure can significantly impact the drug's efficacy. Among these, benzimidazoles are particularly significant. These class of compounds comprises a combination of the aromatic benzene ring and an imidazole ring. A significant natural form of benzimidazole found in nature is N-ribosyl-dimethy
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6

Lüpfert, Sandra, and Willy Friedrichsen. "Heteropentalenes with a Fused Imidazole or 1,2,4-Triazole Ring and One Bridgehead Nitrogen Atom." In Advances in Heterocyclic Chemistry. Elsevier, 1997. http://dx.doi.org/10.1016/s0065-2725(08)60084-7.

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Journal articles
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