Relevant bibliographies by topics / Fused pyrimidines

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Academic literature on the topic 'Fused pyrimidines'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Fused pyrimidines"

1

Dawood, Dina H., Eman M. H. Abbas, Thoraya A. Farghaly, Mamdouh M. Ali, and Mohammed F. Ibrahim. "ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2." Medicinal Chemistry 15, no. 3 (2019): 277–86. http://dx.doi.org/10.2174/1573406414666180912113226.

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Background: Pyrimidines emerged as a remarkable class of heterocyclic compounds that have reinforced the pharmaceutical chemistry with various bioactive antitumor agents. Moreover, pyrimidine scaffold displayed VEGFR-2 inhibitory activity. Also, nano-sized catalysts are used in organic reactions in order to speed up the catalytic process. Objective: We were interested herein to synthesize a new series of fused pyrimidines using ZnO(NPs) to investigate their antitumor efficiency against breast MCF7 cancer and their VEGFR- 2 inhibition properties. Method: A simple and efficient method for the sy
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Sarwade, Prakash Pralhad, K. M. Srinandhinidevi, Kiran Dangwal, et al. "Role of Pyrimidine Derivatives in the Treatment of Cancer." Journal for Research in Applied Sciences and Biotechnology 3, no. 5 (2024): 181–93. http://dx.doi.org/10.55544/jrasb.3.5.19.

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The study of the chemistry of pyrimidines is contributing to the expansion of research into the therapeutic applications of these compounds. In the field of medicinal chemistry, the sheer number of pyrimidine synthesis methods and reactions that are available opens up a world of possibilities. These investigations have been inspired by the fact that pyrimidines can be used as building blocks for a wide variety of compounds that have a physiological effect. The pyrimidine ring and its fused derivatives, which include pyrazolo[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, quinazoline, and furo[2,3-
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3

Hossain, M. I., and M. M. H. Bhuiyan. "Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives." Journal of Scientific Research 1, no. 2 (2009): 317–25. http://dx.doi.org/10.3329/jsr.v1i2.2299.

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Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6 dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitril
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Behera, Manoranjan, M. Sambaiah, Poosa Mallesham, et al. "Tandem Schiff-Base Formation/Heterocyclization: An Approach to the Synthesis of Fused Pyrazolo–Pyrimidine/Isoxazolo-Pyrimidine Hybrids." Synlett 30, no. 05 (2019): 586–92. http://dx.doi.org/10.1055/s-0037-1612081.

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A new synthesis of pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines is described. Key steps in the synthesis involve Stille coupling of 4,6-dichloro-2-phenyl-pyrimidine with tributyl(1-ethoxyvinyl)stannane and tandem Schiff-base formation/heterocyclization of 2,6-di-aryl-5-fluoro-4-acetylpyrimidine with hydrazines or ­hydroxylamine to give pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines, respectively. The position of the fluoro group in the ­pyrimidine ring is important for the success of heterocylization reaction.
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Sahu, Pramod K., Praveen K. Sahu, Manvendra S. Kaurav, et al. "One-pot facile and mild construction of densely functionalized pyrimidines in water via consecutive C–C and C–S bonds formation." RSC Advances 8, no. 59 (2018): 33952–59. http://dx.doi.org/10.1039/c8ra04363a.

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Fused pyrimidines composed of alternating heteroatoms and a pyrimidine moiety were synthesized efficiently using readily available starting material 4-hydroxycoumarin, aromatic aldehydes, and urea/thiourea at room temperature.
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R., PRASAD REDDY, RAVINDRANATH A., SUDHAKAR B., SUNDARA RAMAIAH T., and VENKATESHWER RAO M. "Azatriterpenes. Part-VIII. Synthesis of Ring-A Fused Pyrimidines of Pentacyclic Triterpenes." Journal of Indian Chemical Society Vol. 65, Oct 1988 (1988): 688–90. https://doi.org/10.5281/zenodo.6076530.

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Department of Chemistry, Nizam College (Osmania University), Hyderabad-500 001 <em>&nbsp;Manuscript received 5 April 1988, accepted 27 July 1988</em> Condensation of urea, guanidine and thiourea with 2-formyl (hydroxymethylene) derivatives of methyl oleanonate (1), 11-oxomethyl oleanonate (2) and methyl betulonate (3) furnished their respective [3,2-d]pyrimidine-2&#39;-ones (4 -6), 2&#39;-imino-[3,2-d]pyrimidines (7-9) and 2&#39;-mercapto [3,2-<em>d</em>]pyrimidines (10 -12). The compounds were characterised by their elemental and spectral data.
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7

SB, Patil. "Anticancer Potential of Novel Pyrimidine Analogs: Recent Updates." Medicinal and Analytical Chemistry International Journal 8, no. 1 (2024): 1–6. http://dx.doi.org/10.23880/macij-16000189.

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Pyrimidine, having two nitrogen atoms, looks like pyridine and benzene. In nature, pyrimidine is present in different forms, such as the bases of DNA and RNA. Due to its structure, various kinds of biological activity have been observed. The substituted and fused pyrimidine derivatives were chemically synthesized and showed anti-cancer potential against cancer cell lines (SW480, A549, CCRF-CEM, THP-1, HepG2, HCT-116, PC3, Huh-7, CNE-2, MGC-803, and MDA-MB-435). Based on the experimental results, the substituted pyrimidines and fused derivatives showed remarkably enhanced anticancer activity, w
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8

Latif, F. M. Abd El, A. S. Maghraby, M. A. Barsy, M. Z. A. Badr, and D. Dopp. "New Pyrazoline Derivatives." Collection of Czechoslovak Chemical Communications 59, no. 1 (1994): 247–52. http://dx.doi.org/10.1135/cccc19940247.

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The biological activity of azoles, pyrimidines as well as pyrazolines are of interest. Formation of pyrazolines and related compounds from hydrazine derivatives and α,β-unsaturated carbonyl compounds is very common. Pyrazoline fused with different heterocyclic nuclei at position 4 and 5 have been reported. Here we report the synthesis of some new monocyclic or fused azoles and pyrimidinones linked to C-4 or 5-chloro-3-methyl-1-phenylpyrazoline.
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9

Vincetti, Paolo, Gabriele Costantino, Maria Grazia Martina, and Marco Radi. "Probing the Reactivity of 2,4-Dichlorofuro[3,4-d]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives." Synlett 30, no. 17 (2019): 2010–14. http://dx.doi.org/10.1055/s-0039-1690205.

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Herein, we describe the results of our investigation on the chemical reactivity and versatility of a poorly explored scaffold: 2,4-dichlorofuro[3,4-d]pyrimidin-7-one (3). Highly functionalized pyrimidines can be obtained with a divergent approach by reacting the key intermediate 3 with different amine nucleophiles under carefully controlled reaction conditions. The set-up of a microwave-assisted one-pot, two- or three-step protocol to rapidly generate 2,4,5,6-tetrasubstituted or fused pyrimidines is also reported.
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10

Dodonova, Jelena, and Sigitas Tumkevicius. "Fused Pyrrolo[2,3-d]pyrimidines (7-Deazapurines) by Palladium-Catalyzed Direct N–H and C–H Arylation Reactions." Synthesis 49, no. 11 (2017): 2523–34. http://dx.doi.org/10.1055/s-0036-1588734.

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Palladium-catalyzed intramolecular direct C–H arylations for the synthesis of hitherto unknown fused hetero systems containing an incorporated pyrrolo[2,3-d]pyrimidine scaffold are described. Pyrimido[5′,4′:4,5]pyrrolo[2,1-a]isoindoles were synthesized from 2,4-di­arylpyrrolo[2,3-d]pyrimidines and o-bromobenzyl bromides by using a cascade N-benzylation/C–H arylation reaction sequence. A series of pyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines were successfully assembled via a domino process involving the palladium-catalyzed direct double C–H arylation reactions of 2,4,7-triarylpyrrolo[2,3-d]
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Books on the topic "Fused pyrimidines"

1

J, Brown D., ed. Fused pyrimidines. Wiley, 1988.

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Delia, Thomas J. Miscellaneous fused pyrimidines. Wiley, 1992.

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Warner, John C., and Thomas J. Delia. Fused Pyrimidines, Part 4: Miscellaneous Fused Pyrimidines. Wiley & Sons, Incorporated, John, 2009.

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Delia, Thomas J. Miscellaneous Fused Pyrimidines, Volume 24, Part 4, Fused Pyrimidines. Wiley-Interscience, 1991.

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5

Armarego, W. L. F. Fused Pyrimidines, Part 1. Wiley & Sons, Incorporated, John, 2009.

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Brown, D. J. Fused Pyrimidines, Part 3: Pteridines. Wiley & Sons, Incorporated, John, 2009.

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Lister, John H. Fused Pyrimidines, Part 2: The Purines. Wiley & Sons, Incorporated, John, 2009.

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Armarego, W. L. F. Chemistry of Heterocyclic Compounds, Fused Pyrimidines. Wiley & Sons, Incorporated, John, 2008.

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Warner, John C., and Thomas J. Delia. Chemistry of Heterocyclic Compounds, Fused Pyrimidines - . Wiley & Sons, Incorporated, John, 2007.

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Brown, D. J. Chemistry of Heterocyclic Compounds, Fused Pyrimidines: Pteridines. Wiley & Sons, Incorporated, John, 2007.

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Book chapters on the topic "Fused pyrimidines"

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S. Laitonjam, Warjeet, and Nimalini Moirangthem. "Construction of Biologically Active Five- and Six-Membered Fused Ring Pyrimidine Derivatives from 1,3-Diarylthiobarbituric Acids (DTBA)." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108842.

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Several derivatives of fused pyrimidines were synthesized in maximum yields by using the respective condensation products, namely, 5-ethoxymethylene-1,3-diaryl-2-thiobarbituric acids and 5-phenyl-methylene-1,3-diaryl-2-thiobarbituric acids, which can be obtained from 1,3-diarylthiobarbituric acids (DTBA). These condensation products possessing three electrophilic centres could undergo cyclocondensation with various binucleophiles to give various fused heterocycles of pyrimidine derivatives, such as pyrazolo[3,4-d]pyrimidine-6-thiones, 5,7-diaryl-4-oxo-isoxazolo[5,4-d]pyrimidine-6-thiones, 5-ox
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Najajreh, Yousef, and Maha Awwad Khoury. "Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.109103.

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Diazine alkaloid (pyridazine, pyrimidine and pyrazine) scaffold, a widespread two-nitrogen containing compounds in nature (DNA, RNA, flavors, and fragrances), constitutes a central building block for wide range of pharmacological applications. Diazines are reported to exhibit antimetabolite (antifolate and), anticancer, antibacterial, antiallergic, tyrosine kinase, antimicrobial, calcium channel antagonistic, anti-inflammatory, analgesic, antihypertensive, antileishmanial, antituberculostatic, anticonvulsant, diuretic and potassium-sparing, to antiaggressive activities. Pyridazine (1,2-diazine
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Borzilleri, R. M. "Annulated Diazocines by Cycloaddition of Fused Pyridazines and Pyrimidines with Electron-Rich Ynamines." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-01562.

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Fülöp, Ferenc, Gábor Bernáth, and Kalevi Pihlaja. "Synthesis, Stereochemistry and Transformations of Cyclopentane-, Cyclohexane-, Cycloheptane-, and Cyclooctane-Fused 1,3-Oxazines, 1,3-Thiazines, and Pyrimidines." In Advances in Heterocyclic Chemistry. Elsevier, 1997. http://dx.doi.org/10.1016/s0065-2725(08)60085-9.

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Arora, Sahil, and Raj Kumar. "FDA approved six-membered ring fused pyrimidine-based derivatives." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.00011-9.

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Singh, Pankaj Kumar. "Molecular modeling studies of fused pyrimidine derivatives at various receptors." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.00010-7.

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Ansari, Arshad J., and Gaurav Joshi. "Eight-membered fused pyrimidine derivatives and their biological properties." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.00001-6.

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"Biographies." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.00009-0.

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"Front Matter." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.01001-2.

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"Copyright." In Fused Pyrimidine-Based Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18616-5.12001-0.

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Conference papers on the topic "Fused pyrimidines"

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Slivka, Mar V., M. M. Fizer, D. Zh Bereksazi, et al. "Preparation of Bioactive Fused Pyrimidines via Environmental Technologies." In 2019 International Council on Technologies of Environmental Protection (ICTEP). IEEE, 2019. http://dx.doi.org/10.1109/ictep48662.2019.8968984.

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Gangjee, Aleem, Weiguo Xiang, Susan L. Mooberry, and Ernest Hamel. "Abstract 836: Potent antitubulin and antitumor activities influenced by the 3-D conformational shape of bicyclic fused pyrimidines." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-836.

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Hsu, Yung Chang, Hui-Yi Shiao, Yi-Yu Ke, et al. "Abstract 2530: Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2530.

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