Relevant bibliographies by topics / Fusion en PEG

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  2. Dissertations / Theses
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Academic literature on the topic 'Fusion en PEG'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "Fusion en PEG"

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Charoenpanich, Jittima, Akio Tani, Naoko Moriwaki, Kazuhide Kimbara, and Fusako Kawai. "Dual regulation of a polyethylene glycol degradative operon by AraC-type and GalR-type regulators in Sphingopyxis macrogoltabida strain 103." Microbiology 152, no. 10 (October 1, 2006): 3025–34. http://dx.doi.org/10.1099/mic.0.29127-0.

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The genes for polyethylene glycol (PEG) catabolism (pegB, C, D, A and E) in Sphingopyxis macrogoltabida strain 103 were shown to form a PEG-inducible operon. The pegR gene, encoding an AraC-type regulator in the downstream area of the operon, is transcribed in the reverse direction. The transcription start sites of the operon were mapped, and three putative σ 70-type promoter sites were identified in the pegB, pegA and pegR promoters. A promoter activity assay showed that the pegB promoter was induced by PEG and oligomeric ethylene glycols, whereas the pegA and pegR promoters were induced by PEG. Deletion analysis of the pegB promoter indicated that the region containing the activator-binding motif of an AraC/XylS-type regulator was required for transcription of the pegBCDAE operon. Gel retardation assays demonstrated the specific binding of PegR to the pegB promoter. Transcriptional fusion studies of pegR with pegA and pegB promoters suggested that PegR regulates the expression of the pegBCDAE operon positively through its binding to the pegB promoter, but PegR does not bind to the pegA promoter. Two specific binding proteins for the pegA promoter were purified and identified as a GalR-type regulator and an H2A histone fragment (histone-like protein, HU). The binding motif of a GalR/LacI-type regulator was found in the pegA and pegR promoters. These results suggested the dual regulation of the pegBCDAE operon through the pegB promoter by an AraC-type regulator, PegR (PEG-independent), and through the pegA and pegR promoters by a GalR/LacI-type regulator together with HU (PEG-dependent).
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Suchyta, Marissa, Si-Gyun Roh, Diya Sabbagh, Mohammed Morsy, Huan Wang, and Samir Mardini. "4362 The Utilization of Polyethylene Glycol Fusion to Improve Facial Reanimation." Journal of Clinical and Translational Science 4, s1 (June 2020): 103. http://dx.doi.org/10.1017/cts.2020.319.

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OBJECTIVES/GOALS: This study’s goal is to determine whether intraoperative treatment of facial nerves with polyethylene glycol (PEG) fusion technology improves facial paralysis outcomes. Improved facial nerve regeneration in facial paralysis patients would lead to improved recovery time and effectiveness. METHODS/STUDY POPULATION: 30 rats were utilized; 15 underwent facial nerve regeneration without PEG fusion, and 15 with PEG fusion. Facial paralysis was initiated on the left by transection of the buccal and marginal mandibular branches of facial nerve. The buccal branch was repaired though microsuture technique. Neurorrhaphy sites of rats in the PEG group were exposed to calcium free saline, methylene blue, and polyethylene glycol. Nerve continuity was assessed post-operative in 5 animals in each group through electron microscopy. Functionality was assessed in the other 10 per group by EMG and whisker analysis after surgery, and weekly for 8 weeks. At 8 weeks, nerves and distal muscles were histologically analyzed. RESULTS/ANTICIPATED RESULTS: PEG fusion technology immediately restored axonal continuity following surgery, demonstrated by electron microscopy. Electrophysiology was also similarly restored across the site immediately, determined through intraoperative nerve stimulation, in the PEG fusion group. The nonintervention group showed dramatically reduced functional recovery than the PEG fusion group following surgery, shown by lower whisking activity and poor electrophysiology outcomes. Furthermore, the PEG fusion group showed statistically significant higher fascicle counts, myelination diameter, axonal diameter, and distal muscle fibers histologically. DISCUSSION/SIGNIFICANCE OF IMPACT: This study demonstrates that polyethylene fusion technology may improve facial reanimation outcomes. PEG is already a FDA-approved drug, and thus the pathway to translational clinical application of this work may thus be streamlined, bringing new options to patients with facial paralysis.
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Khalili, H., P. T. Khaw, and S. Brocchini. "Fc-fusion mimetics." Biomaterials Science 4, no. 6 (2016): 943–47. http://dx.doi.org/10.1039/c6bm00077k.

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Nakajima, Naoki, and Yoshito Ikada. "Effect of Solution Osmotic Pressure on Cell Fusion by Poly(Ethylene Glycol)." Journal of Bioactive and Compatible Polymers 10, no. 1 (January 1995): 14–27. http://dx.doi.org/10.1177/088391159501000103.

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Effects of the osmotic pressure of culture medium on the membrane fusion of L929 cells in the monolayer state were investigated using polyethylene glycol) (PEG) with the molecular weight of 3,000 at various concentrations at phosphate buffer saline (PBS). Cell incubation for fusion was performed via three stages; (1) incubation before PEG treatment (preincubation), (2) incubation in the presence of PEG (PEG incubation), and (3) incubation after PEG treatment (postincubation). The PBS concentrations half that of a isotonic solution in the pre- and postincubation stages significantly accelerated the membrane fusion, whereas cell treatment at more hypotonic or hypertonic concentrations of PBS suppressed cell fusion. This result was explained in terms of cell swelling and shrinking induced by the osmotic pressure difference, because such cell morphological changes actually occurred when the PBS concentration was varied from the isotonicity. In contrast, almost no effect of osmotic pressure on cell fusion was observed if PEG was present in the culture medium at 40 w/w% concentration, regardless of the PBS concentration.
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Ratanasanobon, K., and K. A. Seaton. "PEG FUSION OF CHAMELAUCIUM UNCINATUM PROTOPLASTS." Acta Horticulturae, no. 829 (June 2009): 359–64. http://dx.doi.org/10.17660/actahortic.2009.829.57.

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Mizuta, Yoshihiro, and Kozo Taguchi. "Efficient PEGfusion Combinedoptical Tweezers and Dielectrophoresis." Applied Mechanics and Materials 595 (July 2014): 61–64. http://dx.doi.org/10.4028/www.scientific.net/amm.595.61.

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Cell fusionis difficult so that research institutions try to fusion with many methods. For example, method of using polyethylene glycol (PEG) is useful and it mainly use in fusion. However cell fusion efficiency of this method is less. In this paper we suggest efficient fusion of PEG with combining optical tweezers and dielectrophoresis (DEP). Optical tweezers is useful tool in cell manipulation ant it has features of non-invasive and non-contact. Using this technique, we can take target cell from many cells. DEP are known to manipulate cell and form pearl chain by non-uniform electric field. We think DEP lead to efficient cell fusion of PEG because probability of cell adhered by only PEG is less.So we performed firstly take protoplast of red cabbage as specific cell from cells to parallel electrodes by optical tweezers and second, we observed cell-cell fusion by PEG with cell formed pearl chain by DEP. Furthermore we demonstrated using optical tweezers at 980 nm, showed manipulation dates of polymer microspheres, yeast cell and protoplast of red cabbage.
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Roos, D. S., and P. W. Choppin. "Biochemical studies on cell fusion. I. Lipid composition of fusion-resistant cells." Journal of Cell Biology 101, no. 4 (October 1, 1985): 1578–90. http://dx.doi.org/10.1083/jcb.101.4.1578.

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A series of stable cell mutants of mouse fibroblasts were previously isolated (Roos, D. S. and R. L. Davidson, 1980, Somatic Cell Genet., 6:381-390) that exhibit varying degrees of resistance to the fusion-inducing effect of polyethylene glycol (PEG), but are morphologically similar to the parental cells from which they were derived. Biochemical analysis of these mutant cell lines has revealed differences in whole cell lipid composition which are directly correlated with their susceptibility to fusion. Fusion-resistant cells contain elevated levels of neutral lipids, particularly triglycerides and an unusual ether-linked lipid, O-alkyl, diacylglycerol. This ether lipid is increased approximately 35-fold over parental cells in the most highly PEG-resistant cell line. Fusion-resistant cells also contain more highly saturated fatty acyl chains (ratio of saturated to polyunsaturated fatty acids [S/P ratio] approximately 4:1) than the parental line (S/P ratio approximately 1:1). Cells which are intermediate in their resistance to PEG have ether lipid and fatty acid composition which is intermediate between the parental cells and the most fusion-resistant mutants. In a related communication (Roos, D. S. and P. W. Choppin, 1985, J. Cell. Biol., 100:1591-1598) evidence is presented that alteration of lipid content can predictably control the fusion response of these cells.
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Roos, D. S., and P. W. Choppin. "Biochemical studies on cell fusion. II. Control of fusion response by lipid alteration." Journal of Cell Biology 101, no. 4 (October 1, 1985): 1591–98. http://dx.doi.org/10.1083/jcb.101.4.1591.

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The preceding communication (Roos, D.S. and P.W. Choppin, 1985, J. Cell Biol. 101:1578-1590) described the lipid composition of a series of mouse fibroblast cell lines which vary in susceptibility to the fusogenic effects of polyethylene glycol (PEG). Two alterations in lipid content were found to be directly correlated with resistance to PEG-induced cell fusion: increases in fatty acyl chain saturation, and the elevation of neutral glycerides, including an unusual ether-linked compound. In this study, we have probed the association between lipid composition and cell fusion through the use of fatty acid supplements to the cellular growth medium, and show that the fusibility of cells can be controlled by altering their acyl chain composition. The parental Clone 1D cells contain moderately unsaturated fatty acids with a ratio of saturates to polyunsaturates (S/P) approximately 1 and fuse virtually to completion following a standard PEG treatment. By contrast, the lipids of a highly fusion-resistant mutant cell line, F40, are highly saturated (S/P approximately 4). When the S/P ratio of Clone 1D cells was increased to approximate that normally found in F40 cells by growth in the presence of high concentrations of saturated fatty acids, they became highly resistant to PEG. Reduction of the S/P ratio of F40 cells by growth in cis-polyunsaturated fatty acids rendered them susceptible to fusion. Cell lines F8, F16, etc., which are normally intermediate between Clone 1D and F40 in both lipid composition and fusion response, can be altered in either direction (towards either increased or decreased susceptibility to fusion) by the addition of appropriate fatty acids to the growth medium. Although trans-unsaturated fatty acids have phase-transition temperatures roughly similar to saturated compounds, and might therefore be expected to affect membrane fluidity in a similar manner, trans-unsaturated fatty acids exerted the same effect as cis-unsaturates on the control of PEG-induced cell fusion. This observation suggests that the control of cell fusion by alteration of fatty acid content is not due to changes in membrane fluidity, and thus that the fatty acids are involved in some other way in the modulation of cell fusion.
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Ahkong, Q. F., J. P. Desmazes, D. Georgescauld, and J. A. Lucy. "Movements of fluorescent probes in the mechanism of cell fusion induced by poly(ethylene glycol)." Journal of Cell Science 88, no. 3 (October 1, 1987): 389–98. http://dx.doi.org/10.1242/jcs.88.3.389.

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It has been claimed that purified poly(ethylene glycol) (PEG) is able only to aggregate cells and not to fuse them. In our hands, purified PEG 6000 (recrystallized/dialysed) induces both aggregation and fusion of human erythrocytes, and the mechanism of fusion by the purified polymer has been investigated with fluorescent probes. No movement of a carbocyanine probe or of octadecyl rhodamine B chloride from labelled to unlabelled cells occurred in the absence of PEG or with cells treated with concanavalin A, protamine or spermine. With 40% PEG, however, both probes immediately started to diffuse into the membranes of unlabelled cells. This indicates that continuity between the phospholipid bilayer membranes of adjacent erythrocytes (i.e. membrane fusion) is established within seconds in concentrated solutions of the polymer, and precedes the cell fusion event that is induced by purified PEG. These observations are consistent with the idea that micro-regions of shared phospholipid bilayer may be formed in the membranes of cells when they are forced together as a consequence of the dehydrating action of PEG. Intact erythrocytes were cytoplasmically labelled with 6-carboxyfluorescein to avoid the possibility that loading the cells with a cytoplasmic marker by hypotonic haemolysis might modify their response to PEG. Unlike the lipid probes, carboxyfluorescein did not diffuse from labelled to unlabelled cells in the presence of 40% PEG, and there was little diffusion on subsequent dilution of the polymer solution to 13%. However, after the PEG solution had been replaced by an isotonic buffer, a rapid transfer of the cytoplasmic fluorophore to unlabelled cells often occurred. This is considered to be more consistent with the osmotic rupture of a membranous barrier, such as a shared bilayer, between the labelled and unlabelled cells than with the return of cytoplasmic viscosity to normal when the PEG is removed. Possible reasons are discussed for the reported inability of purified PEG to fuse fibroblasts with hypotonically loaded human erythrocytes.
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Takei, Shunsuke, Makoto Yamamoto, Li Cui, Fengming Yue, Kohei Johkura, Naoko Ogiwara, Hisae Iinuma, Kota Okinaga, and Katsunori Sasaki. "Phenotype-Specific Cells with Proliferative Potential are Produced by Polyethylene Glycol-Induced Fusion of Mouse Embryonic Stem Cells with Fetal Cardiomyocytes." Cell Transplantation 14, no. 9 (October 2005): 701–8. http://dx.doi.org/10.3727/000000005783982693.

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Because cardiomyocytes lose the ability to divide upon differentiation, myocardial failure is assumed to be generally irreversible. For terminal cardiac insufficiency, the potential for regenerative treatment by stem cells, especially embryonic stem (ES) cells, offers hope for the future. Recent studies showed that stem cells fuse spontaneously with cells remaining in damaged tissues, and restore tissue function. To imitate spontaneous fusion in vivo, we used polyethylene glycol (PEG) in vitro to fuse mouse ES cells and fetal cardiomyocytes and analyzed the cytochemical properties of the fused cells. Confocal laser scanning microscopy coupled with lipophilic dye labeling of the living cell membranes showed that there were fused cells of ES cells and cardiomyocytes after PEG treatment. By flow cytometry, the fusion efficiency between ES cells and cardiomyocytes was estimated to be about 45% of the total resulting cells. When green fluorescent protein (GFP)-expressing ES cells were fused with cardiomyocytes, the fused cells had immunoreactivity for GFP in their cytoplasm and cardiac troponin I in their myofibrils. Some of these cells also expressed proliferating cell nuclear antigen up to 11 days after fusion, the last time point examined. This study shows that PEG-induced fusions of mouse ES cells and cardiomyocytes have the cardiomyocyte phenotype and proliferation potential.
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Dissertations / Theses on the topic "Fusion en PEG"

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Locardel-Rietzler, Joëlle. "Recherche de nouveaux liants polymères substituts du PEG dans le procédé de granulation par fusion." Montpellier 1, 2000. http://www.theses.fr/2000MON13510.

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Serhal, Karine. "Production et caractérisation d'hybrides cellulaires obtenus par la fusion de cellules dendritiques et cellules de carcinome mammaire T-47D dans un but de vaccination anti-tumorale." Paris 6, 2007. http://www.theses.fr/2007PA066663.

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Dans le contexte de l’immunothérapie anti-tumorale, la fusion des cellules dendritiques (DC) avec les cellules tumorales a pour but d’obtenir des cellules fusionnées capables d’éradiquer les tumeurs établies ou d’empêcher leur développement. Nos objectifs sont : (1) d’optimiser la production de cellules fusionnées et de les caractériser en identifiant les faux positifs, (2) d’étudier leur immuno-phénotype et leur fonctionnalité. Ce travail permet de réduire les facteurs de variabilité du processus de fusion DC/cellules tumorales et d’insister sur la complémentarité des méthodes de caractérisation. Les cellules fusionnées sont capables d’induire une réponse immunitaire et leur fonctionnalité, liée à leur état de maturation, se manifeste par la sécrétion de cytokines et de perforine par les LT activés. Leur phénotype non adhérent et leur capacité à exprimer le gène CCR7 ouvrent la voie à des expériences de migration et d’évaluation de l’activité anti-tumorale chez l’animal.
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Cantin, Oriane. "PEO hot melt extrudates for controlled drug delivery." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S035/document.

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Parmi les procédés de fabrication continue, l’extrusion par fusion à chaud est une technique dont l’intérêt dans le domaine pharmaceutique est grandissant. Ce procédé permet la formation des dispersions solides des substances actives au sein des matrices polymériques ou lipidiques. En fonction de l’excipient et de la substance active, cela peut être largement utilisé pour la conception des systèmes: (i) pour une libération immédiate, (ii) pour une libération modifiée et (iii) pour le masquage de goût. Les systèmes à libération modifiée sont des dispositifs intéressants qui permettent d’améliorer la biodisponibilité de la substance active, son efficacité ainsi que l’observance des patients. En fonction de la nature de l’excipient, différents systèmes avec des mécanismes de libération variés peuvent être produit, notamment des matrices inerte, érodable ou gonflante. Le poly éthylène oxide est un polymère semi- cristallin et hydrophile qui peut être utilisé pour la libération contrôlée. Son point de fusion compris entre 63 et 67 °C le rend adapté pour l’extrusion. Surtout, ses capacités de gonflement permettent d’administrer la substance active de façon contrôlée en fonction du poids moléculaire du poly éthylène oxide. Les objectifs de ce travail sont (i) d’étudier l’impact des paramètres critiques du procédé (température d’extrusion et vitesse des vis d’extrudeuse) sur le profil de libération de la substance active, (ii) de déterminer l’impact des paramètres de formulations (poids moléculaire du poly éthylène oxide, charge et type de la substance active) sur le profil de libération de la substance active et (iii) d’évaluer des formes galéniques solides conçues par le procédé d’extrusion à celui de la compression directe. Il a été montré que la variation de la température d’extrusion et de la vitesse des vis altérait l’apparence de l’extrudat et ainsi la distribution de la substance active au sein de l’extrudat. Il s’est avéré dans notre étude que la libération de la substance active n’était pas particulièrement affectée par ces changements de température et vitesse de vis de l’extrudeuse. De plus, cette étude a permis de fixer les paramètres pour les projets suivants: température 100 °C ; vitesse des vis 30 rpm ; longueur de la forme galénique 1 cm. Des extrudats de poly ethylène oxide contenant 10 % de théophylline et du poly éthylène oxide de 100 à 7000 kDa ont été utilisés dans ce travail. Il a été observé que lorsque le poids moléculaire du poly ethylène oxide augmente de 100 à 600 kDa, la libération en substance active diminue de façon importante alors qu’une augmentation jusqu’à 7000 kDa ne diminue que légèrement la libération. Des études du gonflement ont montré que ce phénomène corrélait aux variations de volume de la partie opaque de l’extrudat (gel non transparent et cœur solide)
Among continuous manufacturing processes, hot melt extrusion is a technique with growing interest in the pharmaceutical field. This process enables the formation of solid dispersions of many drugs within a polymeric or lipidic carrier. Hot melt extrusion can be widely used for different issues using the appropriate carrier and drug. Here are the mostly used concepts in pharmaceutical solid dosage forms: (i) immediate release, (ii) modified release and (iii) taste masking. Modified release systems have been taken into account to be very interesting devices for the improvement of drug- bioavailability, drug- efficacy as well as the patient compliance. Various systems with different release mechanisms can be manufactured, depending on the nature of the carrier (inert, erodible, and swelling matrices). Poly ethylene oxide is a semi crystalline and hydrophilic polymer which can be used to control drug delivery. The poly ethylene oxide melting point ranging from 63 to 67 °C makes it suitable for hot melt extrusion. Importantly, the swelling capacities of the hydrophilic poly ethylene oxide matrices are able to deliver drug in a time controlled manner, in respect of the poly ethylene oxide molecular weights. The purposes of this work were (i) to study the impact of critical process parameters (extrusion temperature and screw speed) on the drug release behavior, (ii) to determine the impact of formulation parameters (poly ethylene oxide molecular weight, nature of drug and drug loading) on drug release kinetics, and (iii) to evaluate solid dosage forms prepared by hot melt extrusion versus direct compression. Interestingly, the variation of the extrusion temperature and the screw speed leads to the altering of the extrudate appearance and thus the distribution of drug into the extrudate. However, this changing has not influenced the drug release remarkably. Thus, this study was useful to set the parameters for the following projects (temperature 100 °C; screw speed 30 rpm; dosage form size 1 cm). Poly ethylene oxide hot melt extrudates containing 10 % theophylline and based on 100 - 7,000 kDa poly ethylene oxide are used for this thesis. Importantly, the drug release decreased substantially with the increase of the poly ethylene oxide molecular weight from 100 to 600 kDa. However, further increasing of the molecular weights leads to only a slight decrease in the release rate. Swelling studies have shown that this phenomenon correlated with the change in volume of the opaque part of the extrudates (non-transparent gel and solid core)
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Zheng, Yiran. "CT-PET Image Fusion and PET Image Segmentation for Radiation Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1283542509.

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Rossi, Michele. "Sensor fusion per la localizzazione indoor in applicazioni context-aware." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/12894/.

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Nel contesto della Realtà Aumentata e della tecnologia Wearable, la richiesta, e soprattutto la necessità, di applicazioni context-aware ha reso il concetto di posizione una informazione estremamente importante. Il presente documento mira a fornire una solida base per la progettazione e realizzazione di un sistema di localizzazione indoor attraverso l'uso di sensori inerziali e di tecniche di filtering, in particolare il filtro di Kalman e le varianti Extended e Unscented per la riduzione degli errori di stima, comparandone le performance.
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Scarponi, Valentina. "Data fusion per un nodo sensore basato su piattaforma inerziale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.

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Lo scopo principale dell’elaborato è descrivere la programmazione del nodo sensore LSM6DSL, dotato di accelerometro e giroscopio, al fine di fornire in uscita dati affidabili riguardo all’inclinazione, sia alle basse che alle alte frequenze. L’accelerometro è infatti in grado di produrre informazioni accurate solo alle basse frequenze, mentre il giroscopio dà misure precise solo alle alte. Unendo le due componenti in modo opportuno, si ottiene il dato cercato, con un buon grado di affidabilità. Per trovare il giusto algoritmo di fusione, è stato utilizzato il lavoro di Liu et al, nel quale è proposta una soluzione che prevede l’uso di due filtri complementari, uno passa basso e uno passa alto, per elaborare rispettivamente i dati provenienti da accelerometro e giroscopio e poi fonderli insieme. I filtri sono stati implementati sia come analogici che come digitali. La soluzione teorica prevede l’uso di filtri FIR digitali, intrinsecamente più stabili, ma poiché le due possibilità si sono dimostrate perfettamente sovrapponibili, si è deciso di sfruttare filtri analogici, computazionalmente più facili da realizzare Si è passati poi alla fase di ottimizzazione, necessaria in vista dell’implementazione del programma direttamente sul nodo sensore. L’algoritmo è stato modificato per far sì che i dati provenienti da accelerometro e giroscopio venissero fusi ed elaborati in porzioni composte da un numero di campioni minore rispetto al totale acquisito, riducendo di molto la complessità di operazioni come la trasformata di Fourier. Per minimizzare l’errore introdotto da tale elaborazione, sono stati ricercati numero di campioni e frequenza di taglio ottimali. L'algoritmo risultante è stato prima implementato in ambiente Matlab, poi è stato tradotto in linguaggio C, in modo che il programma potesse essere scritto direttamente sul nodo sensore, in grado a questo punto non solo di acquisire i dati, ma anche di elaborarli in modo opportuno, mantenendo una buona versatilità.
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Kuldkepp, Mattias. "Diagnostics for advanced fusion plasma scenarios." Doctoral thesis, Stockholm : Atomic and Molecular Physics, Department of Physics, Royal Institute of Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4221.

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Kim, Ilseo. "Per-exemplar analysis with MFoM fusion learning for multimedia retrieval and recounting." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52152.

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As a large volume of digital video data becomes available, along with revolutionary advances in multimedia technologies, demand related to efficiently retrieving and recounting multimedia data has grown. However, the inherent complexity in representing and recognizing multimedia data, especially for large-scale and unconstrained consumer videos, poses significant challenges. In particular, the following challenges are major concerns in the proposed research. One challenge is that consumer-video data (e.g., videos on YouTube) are mostly unstructured; therefore, evidence for a targeted semantic category is often sparsely located across time. To address the issue, a segmental multi-way local feature pooling method by using scene concept analysis is proposed. In particular, the proposed method utilizes scene concepts that are pre-constructed by clustering video segments into categories in an unsupervised manner. Then, a video is represented with multiple feature descriptors with respect to scene concepts. Finally, multiple kernels are constructed from the feature descriptors, and then, are combined into a final kernel that improves the discriminative power for multimedia event detection. Another challenge is that most semantic categories used for multimedia retrieval have inherent within-class diversity that can be dramatic and can raise the question as to whether conventional approaches are still successful and scalable. To consider such huge variability and further improve recounting capabilities, a per-exemplar learning scheme is proposed with a focus on fusing multiple types of heterogeneous features for video retrieval. While the conventional approach for multimedia retrieval involves learning a single classifier per category, the proposed scheme learns multiple detection models, one for each training exemplar. In particular, a local distance function is defined as a linear combination of element distance measured by each features. Then, a weight vector of the local distance function is learned in a discriminative learning method by taking only neighboring samples around an exemplar as training samples. In this way, a retrieval problem is redefined as an association problem, i.e., test samples are retrieved by association-based rules. In addition, the quality of a multimedia-retrieval system is often evaluated by domain-specific performance metrics that serve sophisticated user needs. To address such criteria for evaluating a multimedia-retrieval system, in MFoM learning, novel algorithms were proposed to explicitly optimize two challenging metrics, AP and a weighted sum of the probabilities of false alarms and missed detections at a target error ratio. Most conventional learning schemes attempt to optimize their own learning criteria, as opposed to domain-specific performance measures. By addressing this discrepancy, the proposed learning scheme approximates the given performance measure, which is discrete and makes it difficult to apply conventional optimization schemes, with a continuous and differentiable loss function which can be directly optimized. Then, a GPD algorithm is applied to optimizing this loss function.
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Cunningham, Dustin T. "Fusion of Multimodal Neuroimaging for Deep Brain Stimulation Studies." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337895443.

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Pappalardo, Maria. "Misure sperimentali e analisi statistica per la valutazione dell'accuratezza dimensionale di campioni realizzati mediante fabbricazione additiva." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.

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Il presente studio ha posto le basi per la generazione di modelli di correlazione tra parametri di processo e parametri di qualità del prodotto per la tecnologia Multi Jet Fusion. Poiché l'accuratezza dimensionale è ad oggi il principale limite all'applicazione industriale di questa tecnologia, si è deciso di effettuare delle osservazioni e delle misure sperimentali su apposite geometrie benchmark di piccole e medio-grandi dimensioni rispetto allo spazio di costruzione offerto dal sistema HP Jet Fusion 3D 4200. La pianificazione di tali esperimenti è avvenuta con l'obiettivo di generare un modello di correlazione tra l'accuratezza dimensionale e alcuni parametri di processo, quali: dimensione nominale, irradianza ed orientamento. Nello specifico, il lavoro è stato suddiviso come segue. Nel primo capitolo sono state illustrate alcune caratteristiche generali dei processi additivi, per poi passare a descrivere in maniera più dettagliata la tecnologia Multi Jet Fusion. Tale processo è stato analizzato nel capitolo successivo in tutte le sue fasi, dalla progettazione ad hoc dei componenti fino alla fase di post-produzione, ponendo particolare attenzione ai parametri di processo che influenzano la qualità dei componenti stampati. Il terzo capitolo è stato dedicato all’analisi della progettazione degli esperimenti, durante la quale si è messo in evidenza i parametri di processo inclusi e quelli trascurati. Sempre in questo capitolo, sono stati descritti i metodi di misurazione utilizzati, ovvero un calibro digitale e una bilancia di precisione digitale. Infine, nell'ultimo capitolo sono stati descritti e commentati i risultati delle misure effettuate e della loro elaborazione, che è avvenuta per mezzo di tecniche statistiche quali: analisi dei residui, analisi della varianza e analisi di regressione polinomiale.
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Books on the topic "Fusion en PEG"

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Giangiorgio, Pasqualotto, ed. Per una filosofia interculturale. Milano: Mimesis, 2008.

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Giangiorgio, Pasqualotto, ed. Per una filosofia interculturale. Milano: Mimesis, 2008.

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Buechel, Ronny R., and Aju P. Pazhenkottil. Basic principles and technological state of the art: hybrid imaging. Edited by Philipp Kaufmann. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0121.

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The core principle of hybrid imaging is based on the fact that it provides information beyond that achievable with either data set alone. This is attained through the combination and fusion of two datasets by which both modalities synergistically contribute to image information. Hybrid imaging is, thus, more powerful than the sum of its parts, yielding improved sensitivity and specificity. While datasets for integration may be obtained by a variety of imaging modalities, its merits are intuitively best exploited when combining anatomical and functional imaging, particularly in the setting of evaluation of coronary artery disease (CAD) as this combination allows a comprehensive assessment with regard to presence or absence of coronary atherosclerosis, the extent and severity of coronary plaques, and the haemodynamic relevance of stenosis. In clinical practice, the combination of CT coronary angiography (CCTA) with myocardial perfusion studies obtained by single-photon emission computed tomography (SPECT) and by positron emission tomography (PET) has been well established. Recent literature also reports on the feasibility of combining CCTA with cardiac magnetic resonance imaging. Finally, recent advances in CCTA and SPECT imaging have led to a substantial reduction of radiation exposure, now allowing for comprehensive morphological and functional diagnostic work-up by cardiac hybrid SPECT/CCTA imaging at low radiation dose exposures ranging below 5 mSv.
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Kaufmann, Philipp A., and Oliver Gaemperli. Hybrid Cardiac Imaging. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0028.

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Assessment of both coronary anatomy and myocardial perfusion are equally important for the appropriate treatment of patients with stable coronary artery disease. Cardiac hybrid imaging allows integration of coronary anatomy and perfusion in one all-in-one image, thereby avoiding mental integration of findings. In selected subgroups of patients, cardiac hybrid imaging has demonstrated superior diagnostic accuracy compared to single modalities. The combination of coronary anatomy and function provides incremental prognostic information and improves risk stratification of patients with suspected or known CAD. Aside from CT coronary angiography, coronary artery calcium score (CACS) scans obtained from native ECG-triggered CT are used for hybrid imaging. They are used either for attenuation correction, or can be combined with radionuclide information to improve CAD detection and risk stratification. A large number of integrated hybrid scanners are commercially available and offer advantages for cardiac hybrid imaging. However, these devices are not mandatory, and hybrid imaging is perfectly feasible from two separate datasets using appropriate image fusion software. Cardiac magnetic resonance has entered the arena of hybrid imaging and several integrated PET/MRI devices are already commercially available. Its advantages include the lack of ionizing radiation and a high spatial resolution, particularly for soft tissue structures. In research, hybrid imaging moves beyond its conventional borders of perfusion imaging to target specific molecular or biological pathways that underlie cardiac disease, a concept known as molecular imaging. The combination of radionuclide imaging with CT or MRI offers attractive features to co-localize biological signals from radiolabeled targeted compounds with microanatomical structures.
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Strohm, Reinhard, ed. The Music Road. British Academy, 2019. http://dx.doi.org/10.5871/bacad/9780197266564.001.0001.

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The book, derived from the Balzan musicology project ‘Towards a global history of music’, describes cultural traditions and communication patterns of music, dance and theatre in the world region between India and the Mediterranean in the last 2000 years. The new metaphor of the ‘Music Road’—the western half of the ‘Silk Road’—refers to the travels of musical songs, instruments and ideas across both space and time. The book has an introduction and 16 chapters, each by a different author. Highlighted are the following cultural traditions: ancient Gandhāra (first centuries ce); traditions of the Alexander legend; the musical philosophy and practice of Muslim societies; colonial India and the West; Greek music and nationalism (19th–20th centuries); travelling music-theatre companies in the Eastern Mediterranean; the ‘Gypsy rhapsody’ in European art music. The keynote chapter by Martin Stokes reviews the work of Villoteau and Lachmann, advocating a fusion of historical thought and ethnomusicology. The book offers case studies not only on music per se, but also on fine art, dance, musical theatre, on the theology, philosophy, historiography and literature of music, and on East–West relations in the musical practice of colonial and modern times. It is argued in the introduction and implied elsewhere that the musical culture of this world region, and its interactions with the West, have always been on the move, that its diversities and disruptions are counterbalanced by numerous internal and external linkages, and that the reifying term of ‘orientalism’ might be replaced by ‘the East–West imagination’.
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Book chapters on the topic "Fusion en PEG"

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Zhang, Jianwei, and Jörg Raczkowsky. "Sensor Fusion in a Peg-In-Hole Operation with a Fuzzy Control Approach." In Data Fusion Applications, 71–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84990-9_8.

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Arnold, Klaus, Andreas Herrmann, Klaus Gawrisch, and Lothar Pratsch. "Water-Mediated Effects of PEG on Membrane Properties and Fusion." In Molecular Mechanisms of Membrane Fusion, 255–72. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1659-6_19.

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Chand, P. K., E. C. Cocking, A. Lister, M. R. Davey, and J. B. Power. "An Improved Peg Fusion Procedure for Flow Sorting of Plant Protoplasts." In Progress in Plant Protoplast Research, 211–12. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-2788-9_73.

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Binder, Uli, and Arne Skerra. "Half-Life Extension of Therapeutic Proteins via Genetic Fusion to Recombinant PEG Mimetics." In Therapeutic Proteins, 63–80. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527644827.ch4.

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Pietrzyk, U. "Image Fusion." In PET and PET-CT in Oncology, 49–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18803-9_5.

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Jones, S. E. "Can 250+ Fusions Per Muon be Achieved?" In Muon-Catalyzed Fusion and Fusion with Polarized Nuclei, 73–88. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-5930-3_6.

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Bonasera, Aldo. "La fusione nucleare." In Quale energia per il futuro?, 79–94. Milano: Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1418-3_5.

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Wanek, Thomas, Alexander Traxl, Claudia Kuntner-Hannes, and Oliver Langer. "Investigation of Transporter-Mediated Drug-Drug Interactions Using PET/MRI." In Image Fusion in Preclinical Applications, 117–33. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02973-9_6.

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Barani, R., and M. Sumathi. "Adaptive PET/CT Fusion Using Empirical Wavelet Transform." In Proceedings of the Second International Conference on Computational Intelligence and Informatics, 435–45. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8228-3_40.

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Cho, Zang-Hee, Young-Don Son, Young-Bo Kim, and Seung-Schik Yoo. "Fusion of PET and MRI for Hybrid Imaging." In Biomedical Image Processing, 55–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15816-2_2.

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Conference papers on the topic "Fusion en PEG"

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Deng, Huihua, Airong Guo, Mengdie Qian, Xuan Liu, Dingxin Zhou, Zuming Tang, and Zuhong Lu. "Dynamic Monitoring of PEG-Mediated Cell Fusion by RT-CES System." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5162668.

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Pfeiffer, Ferris M., and Dennis L. Abernathie. "The Influence of Facet Fusion Strength on Instrumented Segment Range of Motion." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38082.

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Spinal fusion surgery is one of the most common surgical procedures used to alleviate lower back pain. It is estimated that between 200,000 and 300,000 spine fusion procedures performed each year in the United States [1]. There has been an increase of approximately 8% per year in the frequency of lumbar fusions in the United States since 1980 [2]. Spinal fusion is indicated for treatment of degenerative disk disease, degenerative joint disease, scoliosis, and isthmic and degenerative spondlylotisthesis when more conservative treatments have failed to achieve relief.
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Khandha, Ashutosh D., Sasidhar S. Vadapalli, Scott A. Holekamp, Vijay K. Goel, Christopher M. Bono, and Steve R. Garfin. "Quantifying Motion Across a Solid Lumbar Interbody Fusion Using a Finite Element Model." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-42954.

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Clinical assessment of pseudarthrosis or solid fusion is based on the residual motion across the “fused” segment (Kowalski et al, 2001). Dynamic flexion/extension (F/E) radiographs are commonly used to determine residual motion. Despite widespread use, it is unclear what the appropriate “cut-off” criteria to declare a fusion solid should be, with recommendations ranging from 0 to 5°. These values have not been derived by scientific methods. The present study was initiated to predict the angular sagittal motion across simulated lumbar interbody fusions (IF) using a Finite Element Model (FEM) of the ligamentous lumbar spinal segment. Anterior and posterior lumbar interbody fusions were simulated at the L3–L4 level as per the clinical procedure. Varying degrees of fusion were taken into account and the fusion mass was the simulated as a cancellous core with a cortical shell. The results indicated that 0.5° to 5.14° of angular motion can occur depending on fusion location and degree of completeness. While continuous bone might be noted at surgical exploration, this amount of motion may enable persistent loading of remaining structures, such as the annulus or spinal ligaments. In our view, this may prompt a redefinition of clinically “solid fusion”.
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Hussain, Mozammil, Ahmad N. Nassr, Raghu N. Natarajan, Gunnar B. J. Andersson, and Howard S. An. "Effect of Corpectomy and Discectomy Fusion Procedures on the Stability of Multi-Level Cervical Construct With Anterior Rigid Screw-Plate Fixation: A Finite Element Model Study." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176731.

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Cervical fusion is a traditional surgical technique in the management of spondylotic pathologies. An increased rate of arthrodesis has been well stated in the literature by using anterior and/or posterior instrumentation. Despite excellent results for the multi-level cervical fusions, failures due to the pseudarthrosis, graft dislodgement, migration and screw loosening were reported. These failures were also found to be directly proportional to the number of fused levels. The multi-level fusions with a single strut graft (corpectomy) have only two graft-endplate interfaces and a lower rate of pseudarthrosis failures. But it has a longer lever arm and moment, thus disrupting the normal sagittal alignment of the cervical spine. On the other hand, the multi-level fusion with multiple inter-body grafts (discectomy) maintains the sagittal alignment, but a higher rate of pseudarthrosis failures were expected due to a large number of graft-endplate interfaces. Some investigators have advocated a combination of corpectomy and discectomy, while others believe to perform either one of them due to the individual advantages and disadvantages as per their patient needs. Consequently, a dilemma and controversy still exists in the selection of the type of reconstructive fusion technique. The objective of the present study was to compare the biomechanical stability of the three reconstructive fusion techniques — corpectomy, discectomy and combined corpectomy-discectomy. The stability of the superior motion segment was compared to the inferior motion segment to determine the direction of propagation of the adjacent segment disease.
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Sander, Jennifer, Roland Rodenbeck, Frank Reinert, Wilmuth Muller, and Kim Berude. "Sensor Operation Deployment with Multiple Routes per Asset." In 2018 21st International Conference on Information Fusion (FUSION 2018). IEEE, 2018. http://dx.doi.org/10.23919/icif.2018.8455861.

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Schoening, James R., Danielle K. Duff, Dorothy A. Hines, Keith M. Riser, Tien Pham, Gary H. Stolovy, Jeff Houser, et al. "PED fusion via enterprise ontology." In SPIE Defense + Security, edited by Tien Pham and Michael A. Kolodny. SPIE, 2015. http://dx.doi.org/10.1117/12.2182064.

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Acharya, Raj S., and Nevile Gai. "PET reconstruction using multisensor fusion techniques." In Medical Imaging V: Image Processing, edited by Murray H. Loew. SPIE, 1991. http://dx.doi.org/10.1117/12.45218.

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Wang, Weidong, Dongmei Wu, Pengfei Sun, and Zhijiang Du. "Robot-assisted PET-CT-MRI image fusion." In 2011 IEEE/ICME International Conference on Complex Medical Engineering - CME 2011. IEEE, 2011. http://dx.doi.org/10.1109/iccme.2011.5876784.

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Mertens, Tom, Jan Kautz, and Frank Van Reeth. "Exposure Fusion." In Pacific Graphics '07. 15th Pacific Conference on Computer Graphics and Applications. IEEE, 2007. http://dx.doi.org/10.1109/pg.2007.17.

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Fazlollahi, Amir, Nicholas Dowson, Fabrice Meriaudeau, Stephan Rose, Michael Fay, Paul Thomas, Zeike Taylor, et al. "Automatic Brain Tumour Segmentation in 18F-FDOPA PET Using PET/MRI Fusion." In 2011 International Conference on Digital Image Computing: Techniques and Applications (DICTA). IEEE, 2011. http://dx.doi.org/10.1109/dicta.2011.61.

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Reports on the topic "Fusion en PEG"

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Prucnal, Paul R., Stephen R. Forrest, Hisashi Kobayashi, and Warren S. Warren. FRI-BMDO: Terabit Per Second Networks and Devices for Data Fusion. Fort Belvoir, VA: Defense Technical Information Center, August 2000. http://dx.doi.org/10.21236/ada382784.

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Piert, Morand. Parametric PET/MR Fusion Imaging to Differentiate Aggressive from Indolent Primary Prostate Cancer with Application for Image-Guided Prostate Cancer Biopsies. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada612753.

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Piert, Morand. Parametric PET/MR Fusion Imaging to Differentiate Aggressive from Indolent Primary Prostate Cancer with Application for Image-Guided Prostate Cancer Biopsies. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada598223.

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