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Journal articles on the topic 'G-945'

Author: Grafiati

Published: 25 July 2024

Last updated: 19 July 2025

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Abe, Yuki, Keiko Matsusita, Setsuko Komatsu, and Yukimoto Iwasaki. "Identification of Heterotrimeric G Protein α and β Subunits in Rice." Protein & Peptide Letters 19, no. 3 (2012): 277–81. http://dx.doi.org/10.2174/092986612799363190.

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Moraes, Leonardo A., Karen E. Swales, Jessica A. Wray, et al. "Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets." Blood 109, no. 9 (2007): 3741–44. http://dx.doi.org/10.1182/blood-2006-05-022566.

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Abstract Retinoid X receptors (RXRs) are important transcriptional nuclear hormone receptors, acting as either homodimers or the binding partner for at least one fourth of all the known human nuclear receptors. Functional nongenomic effects of nuclear receptors are poorly understood; however, recently peroxisome proliferator-activated receptor (PPAR) \#947;, PPAR\#946;, and the glucocorticoid receptor have all been found active in human platelets. Human platelets express RXR\#945; and RXR\#946;. RXR ligands inhibit platelet aggregation and TXA2 release to ADP and the TXA2 receptors, but only weakly to collagen. ADP and TXA2 both signal via the G protein, Gq. RXR rapidly binds Gq but not Gi/z/o/t/gust in a ligand-dependent manner and inhibits Gq-induced Rac activation and intracellular calcium release. We propose that RXR ligands may have beneficial clinical actions through inhibition of platelet activation. Furthermore, our results demonstrate a novel nongenomic mode for nuclear receptor action and a functional cross-talk between G-protein and nuclear receptor signaling families.

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Perrault, Raissa, and Peter Zahradka. "Atypical G_αi Signal Transduction." Current Vascular Pharmacology 12, no. 2 (2014): 258–70. http://dx.doi.org/10.2174/1570161112666140226122512.

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SARPONG, S., W. RA, and P. EGGLESTON. "945 Cockroach allergen (Bla g 1) in school dust." Journal of Allergy and Clinical Immunology 97, no. 1 (1996): 419. http://dx.doi.org/10.1016/s0091-6749(96)81163-8.

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Pandurangan, Nanjan, Chinchu Bose, Sreejith Meppoyilam, Veni C. Kalathil, Anjana Murali, and Anjana R. Prameela. "Synthesis, Bioactivities and In-silico Docking Studies of Azaleatin-A Quercetin Partial Methyl Ether: SAR Study." Current Bioactive Compounds 15, no. 1 (2019): 103–8. http://dx.doi.org/10.2174/1573407214666171226155509.

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Background: During last two decades, good progress has been made for the flavonoids in metabolic and infectious diseases. However, expectations have not been fulfilled when these compounds were extended to the in vivo studies, particularly in humans. This could due to low bioavailability and less absorption of flavonoids in the biological systems. A recent study revealed that methylation of flavonoids can bring about dramatic changes in pharmacokinetic and biochemical properties. Often, the partially methylated flavonoids show better activities by improving their metabolic stability, membrane transport capacity, facilitating absorption and for oral bio-availability. Though, partial methyl ethers occupy a large chemical space, their biological properties has not been well established. Azaleatin (quercetin-5-O-methyl ether) is one of such group of naturally occurring molecules. Methods: In the present study, we have utilized methoxymethyl (MOM) protecting groups for the preparation of azaleatin. Synthesized compounds and their derivatives were subjected for &amp;#945;-Amylase and DPPH activities. &amp;#945;-Amylase activity can be measured in vitro by hydrolysis of starch in presence of &amp;#945;-amylase enzyme. Antioxidant capacity was evaluated by measuring the scavenging activity of azaleatin and related compounds on the 2,2- diphenyl-l-1-picrylhydrazil (DPPH) radical. In order to identify the binding mode of the compound azaleatin, Auto Dock Tools (http://mgltools.scripps.edu) were used. Results: Quercetin, along with their derivatives, monomethyl ethers i.e. azaleatin, isorhamnetin, tamarixetin; dimethyl ether i.e. quercetin-3,7-dimethyl ether; quercetin-3,3&amp;#039;,7-trimethyletherpachypodol; quercetin-3,3&#039;,4&#039;7-tetramethyl ether and quercetin pentamethyl ether were taken for &amp;#945;- amylase inhibitory activity. The study showed that azaleatin was found to be comparable with the standard for the inhibition of &amp;#945;-amylase amongst the tested compounds. Since, azaleatin is a best for the inhibition of &amp;#945;-amylase, this compound was taken for the in-silico molecular modelling studies. Azaleatin, showed a good docking energy (-8.8 Kcalmol-1) with the &amp;#945;-amylase receptor. Similarly, other closely related derivatives were studied for their antioxidant capacity. It was found that amongst the compound tested quercetin was found to be best (EC50 of 30&amp;#181;g/mL) for their antioxidant capacity and second best compound was azaleatin; which showed EC50 of 36.1&amp;#181;g/mL. Conclusion: An efficient synthesis of azaleatin, a lesser known flavone has been achieved from quercetin. Amongst the compounds tested, azaleatin was found to inhibit &amp;#945;-amylase with the acceptable radical scavenging activity. Further, in-silico modelling studies indicated that azaleatin found to have very good affinity with the key residues i.e. Gln63, Asp197 and Arg195 of &amp;#945;-amylase receptor. Since, azaleatin has other free hydroxyls in their template, it can be effectively utilized for the activity improvement through further structural modifications.

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Castillo, Pablo, and Ernesto Ibáñez. "PEDRO G. ROMERO, MARÍA GARCÍA RUÍZ - Máquinas de vivir: Flamenco y arquitectura en la ocupación y desocupación de espacios." ZARCH, no. 22 (June 27, 2024): 228. http://dx.doi.org/10.26754/ojs_zarch/zarch.20242210360.

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PEDRO G. ROMERO, MARÍA GARCÍA RUÍZMáquinas de vivir: Flamenco y arquitectura en la ocupación y desocupación de espaciosPuente editores, Barcelona, 2019, 272 pp. Tapa blanda. 17,10 €Idioma: español ISBN: 978-84-9496-945-4

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Freedman, Saul D. "The intersection graph of a finite simple group has diameter at most 5." Archiv der Mathematik 117, no. 1 (2021): 1–7. http://dx.doi.org/10.1007/s00013-021-01583-3.

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AbstractLet G be a non-abelian finite simple group. In addition, let $$\Delta _G$$ Δ G be the intersection graph of G, whose vertices are the proper non-trivial subgroups of G, with distinct subgroups joined by an edge if and only if they intersect non-trivially. We prove that the diameter of $$\Delta _G$$ Δ G has a tight upper bound of 5, thereby resolving a question posed by Shen (Czechoslov Math J 60(4):945–950, 2010). Furthermore, a diameter of 5 is achieved only by the baby monster group and certain unitary groups of odd prime dimension.

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Campbell, Lily, Sarah E. Dudas, Francis Juanes, Gerwing Alyssa M. Allen, and Travis G. Gerwing. "Invertebrate communities, sediment parameters and food availability of intertidal soft-sediment ecosystems on the north coast of British Columbia, Canada." Journal of Natural History 54, no. 15-16 (2020): 919–45. https://doi.org/10.1080/00222933.2020.1770886.

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Campbell, Lily, Dudas, Sarah E., Juanes, Francis, Allen Gerwing, Alyssa M., Gerwing, Travis G. (2020): Invertebrate communities, sediment parameters and food availability of intertidal soft-sediment ecosystems on the north coast of British Columbia, Canada. Journal of Natural History 54 (15-16): 919-945, DOI: 10.1080/00222933.2020.1770886, URL: http://dx.doi.org/10.1080/00222933.2020.1770886

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Kirubasankar, Balakrishnan, Shobana Vijayan, and Subramania Angaiah. "Sonochemical synthesis of a 2D–2D MoSe2/graphene nanohybrid electrode material for asymmetric supercapacitors." Sustainable Energy & Fuels 3, no. 2 (2019): 467–77. http://dx.doi.org/10.1039/c8se00446c.

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A sonochemical route is used to prepare a few layers of MoSe2 and its 2D–2D nanohybrid is prepared with graphene by a solvothermal process. This nanohybrid exhibits a high specific capacitance of 945 F g−1. An ASC device MoSe2/G‖AC is fabricated, which delivers an energy density of 26.6 W h kg−1 and a power density of 0.8 kW kg−1.

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Sinha, Manish, Baljeet Kaur, Amandeep Kaur, Shruti Kuletha, Karanveer Singh, and Rohit Bhatia. "Anticancer Activity of Aminoacid Linked Novel 4-Methylumbelliferone Derivatives." Current Bioactive Compounds 15, no. 1 (2019): 51–62. http://dx.doi.org/10.2174/1573407213666170210143503.

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Background: Cancer is a disease of high mortality. The therapeutic agents currently available are insufficient to cure it and are associated with serious side effects. 4-methylumbelliferone is a natural product containing benzo-&#945;-pyrones as a central nucleus. Benzo-&amp;#945;-pyrone is a privileged moiety having multifarious biological activities including anticancer activity. A series of compounds were synthesized taking 4-methylumbelliferone as a core nucleus and screened for their anticancer activity against HeLa cancer cell line. Methods: The 4-methylumbelliferone was linked with aminoacids using chloroacetyl chloride or ethyl chloroacetate as linker. The N-methylmorpholine and isobutylchloroformate protocol was used for amidic coupling. The final compounds were tested against the HeLa cancer cell lines using SRB assay protocol. Results: Three compounds have shown significant anticancer activity viz 9a, 12f and 15l having GI50 (&amp;#181;g/ml) value of, 56.1, 30.9 and 50.9, respectively. Other compound 9f and 13 showed weak anticancer activity having GI50 (&amp;#181;g/ml) value of 97.2 and 71.1, respectively. Conclusion: It has been found that the synthesized derivatives have inhibitory effect on the growth of cancer cell line. Compound 12f has been found as the most active compound of the synthesized series.

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Maria Pia, Gatta Daniela, Franceschelli Sara, Felaco Mario, and Speranza Lorenza. "Biological Effects of Licochalcones." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 647–56. http://dx.doi.org/10.2174/1389557518666180601095420.

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Medicinal plants and their natural bioactive molecules, are evaluated as the foundation for health preservation and care of humanity. The licorice root, known as “Radix Glycyrrhizae”, is a perennial plant that comes from Mediterranean countries, central to southern Russia, Asia, Turkey, Iraq and Iran. The licorice root has been used in traditional Chinese medicines for centuries and has been defined as &quot;the progenitor of herbs&quot;. The name &#039;Licorice&#039; is derived from the ancient Greek word Glukurrhiza, meaning &#039;sweet root&#039;. It consists of approximately 30 species, however, the most common ones consist of Glycyrrhiza glabra L., Glycyrrhiza uralensis Fisch and Glycyrrhiza Inflata. In addition, the licorice root contains chalcones, which are a part of an important class of natural products and are precursors of flavonoids. Chemically, chalcones are composed of two aromatic rings associated with &#945;, &#946;-unsaturated &#945;-carbon ketone, representing the prima nucleus of the structure. They have been classified, according to chemical structures, in Licochalcone A, B, C, D, E, F and G. This review aims to highlight all the in vitro and in vivo studies that have been conducted on the licochalcones, extracted from Glycyrrhiza species. The main effects are as follows: anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, antiallergic, antidiabetic, hepatotoxic and osteogenic. It is important to implement the introduction of biologically active natural molecules from the bench (research) to the bedside (clinical practice). However, in the future, it is required to conduct additional studies to validate these biological effects.

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Bujak, Kamil, Mateusz Lejawa, Mariusz Gąsior, and Tadeusz Osadnik. "The CTGF gene -945 G/C polymorphism is associated with target lesion revascularization for in-stent restenosis." Experimental and Molecular Pathology 118 (February 2021): 104598. http://dx.doi.org/10.1016/j.yexmp.2020.104598.

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Luscher, Robert M., Felicity Skelton, and Sarah Whitehead. "Book Reviews." Short Fiction in Theory & Practice 9, no. 2 (2019): 161–69. http://dx.doi.org/10.1386/fict_00008_5.

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The American Short Story Cycle, Jennifer J. Smith (2018)Edinburgh: Edinburgh University Press, 194 pp.,ISBN 978-1-47442-393-9, h/bk, £75.00ISBN 978-1-47445-269-4, p/bk, £19.99Dead Voices, F. G. Paci (2019)Toronto: Guernica Editions, 285 pp.,ISBN 978-1-77183-319-6 (EPUB), ISBN 978-1-77183-318-9, p/bk, $25Eye, Marianne Micros (2018)Toronto: Guernica Editions, 142 pp.,ISBN 978-1-77183-258-8 (EPUB), ISBN 978-1-77183-257-1, p/bk, $20Katherine Mansfield and Periodical Culture, Chris Mourant (2019)Edinburgh: Edinburgh University Press, 301 pp.,ISBN 978-1-47443-945-9, h/bk, £80

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Babalola, Olubukola Oluranti, Bartholomew Saanu Adeleke, and Ayansina Segun Ayangbenro. "Whole Genome Sequencing of Sunflower Root-Associated Bacillus cereus." Evolutionary Bioinformatics 17 (January 2021): 117693432110389. http://dx.doi.org/10.1177/11769343211038948.

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In recent times, diverse agriculturally important endophytic bacteria colonizing plant endosphere have been identified. Harnessing the potential of Bacillus species from sunflower could reveal their biotechnological and agricultural importance. Here, we present genomic insights into B. cereus T4S isolated from sunflower sourced from Lichtenburg, South Africa. Genome analysis revealed a sequence read count of 7 255 762, a genome size of 5 945 881 bp, and G + C content of 34.8%. The genome contains various protein-coding genes involved in various metabolic pathways. The detection of genes involved in the metabolism of organic substrates and chemotaxis could enhance plant-microbe interactions in the synthesis of biological products with biotechnological and agricultural importance.

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Singh, Latika, Qingshen Gao, Ajay Kumar, et al. "The High-Risk Human Papillomavirus Type 16 E6 Counters the GAP Function of E6TP1 toward Small Rap G Proteins." Journal of Virology 77, no. 2 (2003): 1614–20. http://dx.doi.org/10.1128/jvi.77.2.1614-1620.2003.

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ABSTRACT We have recently identified E6TP1 (E6-targeted protein 1) as a novel high-risk human papillomavirus type 16 (HPV16) E6-binding protein. Importantly, mutational analysis of E6 revealed a strong correlation between the transforming activity and its abilities to bind and target E6TP1 for ubiquitin-mediated degradation. As a region within E6TP1 has high homology with GAP domains of known and putative Rap GTPase-activating proteins (GAPs), these results raised the possibility that HPV E6 may alter the Rap small-G-protein signaling pathway. Using two different approaches, we now demonstrate that human E6TP1 exhibits GAP activity for Rap1 and Rap2, confirming recent findings that a closely related rat homologue exhibits Rap-specific GAP activity. Using mutational analysis, we localize the GAP activity to residues 240 to 945 of E6TP1. Significantly, we demonstrate that coexpression of HPV16 E6, by promoting the degradation of E6TP1, enhances the GTP loading of Rap. These results support a role of Rap small-G-protein pathway in E6-mediated oncogenesis.

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Elamin, Yasir Y., Tyler Rouskin-Faust, Nicole Zhang, et al. "Abstract LB123: Poorer outcomes in EGFR L858R-driven NSCLC treated with osimertinib may be addressed with novel combination of BLU-945 and osimertinib." Cancer Research 83, no. 8_Supplement (2023): LB123. http://dx.doi.org/10.1158/1538-7445.am2023-lb123.

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Abstract Background: Osimertinib, a 3rd-generation (gen) EGFR tyrosine kinase inhibitor (TKI), is standard of care in front-line (1L) patients with advanced EGFR mutant NSCLC; however, not all subgroups may benefit equally. In the phase 3 FLAURA study, patients with exon 19 deletions (ex19del) had a median progression-free survival (mPFS) of 21.4 months (mo); patients with L858R had a shorter mPFS of 14.4 mo. Poorer outcomes with L858R have also been reported with other 3rd-gen TKIs aumolertinib and lazertinib. These patients are a potential poor-risk subgroup for these therapies. Here, we explored outcomes of patients with L858R-driven NSCLC using real-world datasets (RWDs), analyzed potential contributors to poorer outcomes, including co-mutation incidence and osimertinib potency for each mutation, and report preclinical proof of concept of combination treatment BLU-945, an investigational next-gen L858R inhibitor, with osimertinib. Methods: Two large RWDs were analyzed for survival outcomes in 1L osimertinib-treated patients with ex19del or L858R from MD Anderson Cancer Center (MDACC; n=105) and the clinical-genomic Guardant INFORM database (EGFR ctDNA baseline positive; n=1386). IC50s of osimertinib on EGFR mutations and wildtype were determined in BaF3 cells. Preclinical studies of combination BLU-945 and osimertinib were performed in L858R-driven BaF3 xenograft models. Results: Both RWDs confirmed poorer prognosis for 1L osimertinib-treated patients with L858R vs ex19del. MDACC cohort showed a 12-mo PFS rate of 63% for L858R (n=45) vs 82% for ex19del (n=60); mPFS was immature. Guardant INFORM cohort (ctDNA baseline positive) had a median time-to-treatment discontinuation of 8 mo for L858R (n=517) and 11.4 mo for ex19del (n=869), P=0.003. Poor prognosis factors (including TP53 mutations and co-mutation number) were not significantly different between L858R and ex19del; both had a similar number of off-target mutations in post-osimertinib samples. Strong association was found between osimertinib cellular IC50 and osimertinib clinical trial outcomes (mPFS). Osimertinib exhibited most clinical and cellular activity on ex19del, followed by L858R, then G719X, and then exon 20 insertions. BLU-945 in combination with osimertinib in a BaF3 L858R xenograft model demonstrated a longer duration of response vs osimertinib monotherapy. Conclusions: In both RWDs, 1L osimertinib-treated patients with L858R-driven NSCLC had poorer outcomes vs ex19del, consistent with osimertinib’s weaker activity on L858R. Preclinically, BLU-945 in combination with osimertinib increased L858R inhibition, resulting in more durable antitumor activity in L858R xenografts vs osimertinib alone, supporting rationale for combination treatment in patients with L858R mutations. This combination is being evaluated in 1L patients with L858R in the SYMPHONY study (NCT04862780). Citation Format: Yasir Y. Elamin, Tyler Rouskin-Faust, Nicole Zhang, Teresa Green, Aditya Dhande, Brenton G. Mar, John V. Heymach, Chiara Conti. Poorer outcomes in EGFR L858R-driven NSCLC treated with osimertinib may be addressed with novel combination of BLU-945 and osimertinib [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB123.

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Manjunatha, H. C., N. Sowmya, and A. M. Nagaraja. "Semi-empirical formula for alpha and cluster decay half-lives of superheavy nuclei." Modern Physics Letters A 35, no. 06 (2019): 2050016. http://dx.doi.org/10.1142/s0217732320500169.

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We have formulated a semi-empirical formula for alpha decay half-lives and cluster decay half-lives for superheavy nuclei of atomic number range [Formula: see text]. We have compared the logarithmic half-lives produced by the present formula with that of experiments and other formulae, such as universal decay law (UDL) [H. C. Manjunatha and K. N. Sridhar, Eur. Phys. J. A 53, 156 (2017)] and Horoi et al. [Horoi et al., J. Phys. G[Formula: see text] Nucl. Part. Phys. 30, 945 (2004)], Univ [D. Ni and Z. Ren, Phys. Rev. C 74, 014304 (2006)], Royer [G. Royer, J. Phys. G: Nucl. Part. Phys. 26, 1149 (2000)] and VSS [S. A. Gurvitz and G. Kalbermann, Phys. Rev. Lett. 59, 262 (1987)]. The constructed formula produces logarithmic half-lives for alpha and cluster decay (4He,9Be, [Formula: see text]B, [Formula: see text]C, [Formula: see text]N, [Formula: see text]O, [Formula: see text]F, [Formula: see text]Ne, [Formula: see text]Na, [Formula: see text]Mg, [Formula: see text]Al, [Formula: see text]Si, [Formula: see text]P, [Formula: see text]S, [Formula: see text]Cl, [Formula: see text]Ar, [Formula: see text]K and [Formula: see text]Ca) in superheavy nuclei of atomic number range [Formula: see text].

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SHEKHAR, S., R. RAVINDER REDDY, P. VENUGOPAL REDDY, and V. N. MULAY. "ELASTIC BEHAVIOR OF Y-1-2-3/SILVER COMPOSITES." Modern Physics Letters B 09, no. 08 (1995): 469–83. http://dx.doi.org/10.1142/s0217984995000425.

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A series of Y-1-2-3/Ag high T c superconducting composites have been prepared using the sol–gel method by sintering at three different sintering temperatures, viz. 910°C, 945°C, and 975°C. After the usual characterization by XRD, electrical resistance, bulk density, and porosity measurements, the longitudinal (V1) and shear wave (V s ) velocities were measured by the pulse transmission technique. Using the experimental data, several elasticity parameters such as Young's modulus (E), rigidity modulus (G), etc. were evaluated. The variation of elastic constants with dopant concentration has been explained in terms of the binding forces between various atoms of the superconductor. A linear relationship between the superconducting transition temperature (T c ) and the Debye temperature (θ D ) has also been obtained.

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Liu, Zhigang, Xiaodong Li, Yonghua Leng, et al. "Homogeneous Precipitation Synthesis and Magnetic Properties of Cobalt Ferrite Nanoparticles." Journal of Nanomaterials 2008 (2008): 1–4. http://dx.doi.org/10.1155/2008/921654.

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Magnetic nanoparticles (NPs) of cobalt ferrite have been synthesized via a homogeneous precipitation route using hexamethylenetetramine (HMT) as the precipitant. The particle size, crystal structure, and magnetic properties of the synthesized particles were investigated by X-ray diffraction, transmission electron microscopy, and vibrating sample magnetometer. The NPs are of cubic inverse spinel structure and nearly spherical shape. With the increase of oxidation time from 30 to 180 minutes in the reaction solution at90∘C, the average particle size increases from ~30 nm to ~45 nm. The as-synthesized NPs ~30 nm in size show higherMs(61.5 emu/g) and moderate Hc (945 Oe) andMr/Ms(0.45) value compared with the materials synthesized by coprecipitation method using NaOH as precipitate at high pH value.

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Cieciura-Włoch, Binczarski, Tomaszewska, et al. "The Use of Acidic Hydrolysates after Furfural Production from Sugar Waste Biomass as a Fermentation Medium in the Biotechnological Production of Hydrogen." Energies 12, no. 17 (2019): 3222. http://dx.doi.org/10.3390/en12173222.

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This study investigates a simultaneous processing of sugar beet pulp (SBP) for furfural, hydrogen and methane production using various pretreatment methods. In the experiments, sugar beet pulp was first subjected to thermal and thermochemical pretreatment at 140 °C. Then hydrolysates from these operations were investigated for their potential for methane and hydrogen production in batch tests. The experiments showed that thermal pretreatment of SBP resulted in the highest biogas and methane yields of 945 dm3/kg volatile solids (VS) and 374 dm3 CH4/kg VS, respectively, and a moderate hydrogen production of 113 dm3 H2/kg VS, which corresponded to a calculated energy production of 142 kWh/t; however, only low amount of furfural was obtained (1.63 g/L). Conversely, the highest furfural yield of 12 g/L was achieved via thermochemical pretreatment of SBP; however, biogas production from hydrolysate was much lower (215 dm3/kg VS) and contained only 67 dm3/kg VS of hydrogen. Meanwhile, in the experiment with lower amounts of sulfuric acid (2%) used for pretreatment, a moderate furfural production of 4 g/L was achieved with as high as 220 dm3/kg VS of hydrogen and the corresponding energy yield of 75 kWh/t.

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Mahajan, Supriya, Asmita Gaekwad, Jyoti Pawar, et al. "Cardiac Morbidity in an HIV-1 Lipodystrophy Patient Cohort Expressing the TNF-α-238 G/A Single Nucleotide Gene Polymorphism." Current HIV Research 13, no. 2 (2015): 98–108. http://dx.doi.org/10.2174/1570162x12666141202125016.

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Atiquzzaman, M. "Introduction to Queuing Networks; E. Gelenbe, G. Pujolle; Wiley, New York, 1998. ISBN 0-471-962-945; 240 pp., £34.95." Computer Communications 22, no. 17 (1999): 1621. http://dx.doi.org/10.1016/s0140-3664(99)00133-4.

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Yu, Jialin, Patrick E. McCullough, and Mark A. Czarnota. "First Report of Acetyl-CoA Carboxylase–Resistant Southern Crabgrass (Digitaria ciliaris) in the United States." Weed Technology 31, no. 2 (2017): 252–59. http://dx.doi.org/10.1017/wet.2016.34.

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Two populations of southern crabgrass identified in Georgia turfgrass were suspected to be resistant to sethoxydim. The objectives of this research were to evaluate the resistance levels of these biotypes to acetyl-CoA carboxylase (ACCase) inhibitors and alternative herbicides for control. From dose response experiments, the sethoxydim rate required to reduce shoot biomass 50% from the nontreated measured >64-times greater for both resistant (R) biotypes compared to the susceptible (S) biotype. Both R biotypes were cross-resistant to fenoxaprop and fluazifop. Clethodim at 290 gaiha−1reduced dry shoot biomass of the R biotypes and the S biotype to 47 and 21% of the nontreated, respectively. The R biotypes were equally susceptible to MSMA at 2240 g ai ha−1, quinclorac at 840 g ai ha−1, and topramezone at 37 g ai ha−1as compared to the S biotype. Sethoxydim at 315 and 945 g ha−1provided <20% control of the southern crabgrass populations in four field experiments. However, clethodim and topramezone provided 83% and 76% control at 4 wks after treatment, respectively. These southern crabgrass biotypes are resistant to sethoxydim and aryloxyphenoxypropionate herbicides. Although the R biotypes were less susceptible to clethodim than the S biotype, treatments provided acceptable control in the field. This is the first report of ACCase-resistant southern crabgrass in the United States.

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Verdoy-Herranz, Alfredo. "David G. Schultenover, SJ, Jesuit Superior General Luis Martín García and His «Memorias»: Showing Up, Brill, Leiden / Boston 2021, 945 pp." Anuario de Historia de la Iglesia 31 (April 22, 2022): 695. http://dx.doi.org/10.15581/007.31.42926.

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Patel, Sheila K., Bryan Wai, Richard J. MacIsaac, et al. "The CTGF gene −945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes." Cardiovascular Diabetology 11, no. 1 (2012): 42. http://dx.doi.org/10.1186/1475-2840-11-42.

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Laberiano, Caddie Dy, Edwin Parra, Qiong Gan, Heladio Ibarguen, Shanyu Zang, and Esther Yoon. "945 Characterization of the immune landscape of malignant pleural effusion composition from patients with metastatic breast carcinoma: a pilot study." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A993—A994. http://dx.doi.org/10.1136/jitc-2021-sitc2021.945.

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BackgroundBreast cancer(BC) is the second most common cause after lung cancer of malignant pleural effusions(MPEs),in approximately one third of all MPEs.Although,MPEs are relativity easy to be collated are still not well characterized in their cellular compositions. This opens new avenues to characterize the cellular milieu comprising the MPE, as it has the potential to be highly informative about mutational markers and immune response –ultimately guiding targeted therapy and predicting therapeutic outcomes with their study. The proposed study will characterize immune landscape of the cellular composition of MPE from patients with metastatic breast carcinoma and characterize their relationship with clinicopathologic features in these patients.Abstract 945 Figure 1Comparison between the cell block in H-E and mIF expression CK, CD68 and CD3Abstract 945 Figure 2Composite image in mIF expressing 8 markers. In higher magnification is possible to observe the co expression of CK+Ki67+, CK PDL1, CD3+Foxp3+ and CD3+CD8+Abstract 945 Table 1Results: cell phenotypes in percentage in the six cases analyzedAbstract 945 Table 2Clinical data of the six patients. L: left . R: right , BR : Breast cáncer, CRC: Colorrectal cáncer, NE: No evaluable , IDC : Invasive ductal carcinoma , CT: chemotherapy and BT : biotherapy* Last appointment of the patient.MethodsFive microns thickness paraffin cell pellet blocks from six cases randomly selected of breast carcinoma MPE were stained using a quantitative multiplex immunofluorescence(mIF) panel containing 8 markers against pancytokeratin(CK), PD-L1, PD-1, CD3, CD8, Foxp3, CD68, Ki67, and DAPI (figure 1). Representative regions of interest were scanned using a multispectral scanner (Vectra Polaris) in high magnification (20x) to capture different cell populations. Markers co-expression were processed and analyzed using a quantitative image analysis software (InForm). The final results were obtained as absolute number of cells from each phenotype and were characterized with clinicopathologic features.ResultsWe analyzed and stained six breast cancer MPE cases with previously optimized and validated mIF panel for formalin fixed and paraffin embedded (FFPE) tumor tissues against CK, CD3, CD68, CD8, Foxp3, Ki67, PD1 and PD-L1 (figure 2). The median cellular density was 5870.53 cells. Median for each marker: CK+ was presented in 75.9% (between malignant cells and reactive mesothelial cells) in these cells the expression of Ki67 was 8% and PD-L1+ was present in 0.2%.CD3+ was 0.72% and being the cytotoxic T-cells CD3+CD8+ was 12.13% of these cells and it expression for CD3+PD1+ was in 1.14% without concomitant expression for PD-L1. The median of the macrophages CD68+ was 8.1% of the total cells (table 2).ConclusionsmIF is a promising tool to study diverse corporal effusion from different origin. Although more studies are needed, this new perspective can help us to resolve some clues and possible prognosis in advanced stages of BC.ReferenceNicholas D T, Matthew A. S. Diagnosis and Management of Pleural Metastases and Malignant Effusion in Breast Cancer.En: Kirby I B, Edward M C, V. Suzanne K, William J. G. The Breast (Fifth Edition): Elsevier; 2018. P 934.

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Conway, Andrew R. A., Kristof Kovacs, Han Hao, Kevin P. Rosales, and Jean-Paul Snijder. "Individual Differences in Attention and Intelligence: A United Cognitive/Psychometric Approach." Journal of Intelligence 9, no. 3 (2021): 34. http://dx.doi.org/10.3390/jintelligence9030034.

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Process overlap theory (POT) is a new theoretical framework designed to account for the general factor of intelligence (g). According to POT, g does not reflect a general cognitive ability. Instead, g is the result of multiple domain-general executive attention processes and multiple domain-specific processes that are sampled in an overlapping manner across a battery of intelligence tests. POT explains several benchmark findings on human intelligence. However, the precise nature of the executive attention processes underlying g remains unclear. In the current paper, we discuss challenges associated with building a theory of individual differences in attention and intelligence. We argue that the conflation of psychological theories and statistical models, as well as problematic inferences based on latent variables, impedes research progress and prevents theory building. Two studies designed to illustrate the unique features of POT relative to previous approaches are presented. In Study 1, a simulation is presented to illustrate precisely how POT accounts for the relationship between executive attention processes and g. In Study 2, three datasets from previous studies are reanalyzed (N = 243, N = 234, N = 945) and reveal a discrepancy between the POT simulated model and the unity/diversity model of executive function. We suggest that this discrepancy is largely due to methodological problems in previous studies but also reflects different goals of research on individual differences in attention. The unity/diversity model is designed to facilitate research on executive function and dysfunction associated with cognitive and neural development and disease. POT is uniquely suited to guide and facilitate research on individual differences in cognitive ability and the investigation of executive attention processes underlying g.

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Rhee, Kyung-Hee, Ki-Hyun Nam, Won-Ho Lee, Young-Gyu Ko, Eunice Eunkyeong Kim, and Kwang Yeon Hwang. "Expression, Purification, and Preliminary X-Ray Crystallographic Analysis of the Complex of Gαi3-RGS5 from Human with GDP/Mg2+/AlF4 -." Protein & Peptide Letters 13, no. 9 (2006): 945–49. http://dx.doi.org/10.2174/092986606778256225.

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Farahmandfar, Reza, Maryam Asnaashari, Yegane Asadi, and Batool Beyranvand. "Comparison of Bioactive Compounds of Matricaria recutita Extracted by Ultrasound and Maceration and their Effects on Preventing Sunflower Oil During Frying." Current Nutrition & Food Science 15, no. 2 (2019): 156–64. http://dx.doi.org/10.2174/1573401313666170712110248.

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Background: It is important to study about the use of natural antioxidants as alternatives to synthetic ones due to the possibility of carcinogenic effects of synthetic antioxidants. This study is comparing the effect of the ultrasound-assisted and maceration extraction methods on antioxidant activity of Matricaria recutita. Methods: Bioactive compounds including phenolic, tocopherol, flavonoid and tannins and antioxidant activity of the extracts were evaluated. Moreover, extracts obtained from ultrasound and maceration methods were added to sunflower oil without any antioxidants at level of 200, 500 and 800 ppm, after that samples were heated at 180°C. Oxidation of the samples were evaluated after 0, 4, 8, 12, 16, 20 and 24 hours by measuring Peroxide Value (PV), Conjugated Diene (CD), Iodine Value (IV), Carbonyl Value (CV), Total Polar Compounds (TPC), Oil Stability Index (OSI), Color Index (CI) and acid value (AV). Results: The result showed total phenol (42.90 mg gallic acid/g extract), tocopherol (120.46 &#181;g &#945; - tocopherol/ml extract), flavonoid (2.64 mg/100 g extract) and tannins (3.89 mg gallic acid/g extract) of ultrasound extracts were higher than maceration extracts. Antioxidant activity of the extract was evaluated by DPPH assay which indicated 800 ppm of the Matricaria recutita extracted by ultrasound was the highest radical scavenging ability. Conclusion: Result indicated both ultrasound and maceration extracts could increase the oil oxidative stability but could not increase compared to BHA. In most cases, the extract samples by ultrasound had a better effect on stabilizing of sunflower oil during frying.

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Wang, Qing, Zhi-Ping Jiang, Jing Zeng, et al. "Effects of Trough Concentration and Solute Carrier Polymorphisms on Imatinib Efficacy in Chinese Patients with Chronic Myeloid Leukemia." Journal of Pharmacy & Pharmaceutical Sciences 23, no. 1 (2020): 1–9. http://dx.doi.org/10.18433/jpps30559.

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Purpose: We investigated the relationship between imatinib trough concentrations and genetic polymorphisms with efficacy of imatinib in Chinese patients with chronic myeloid leukemia (CML). Methods: There were 171 eligible patients. Peripheral blood samples were collected from 171 eligible patients between 21 and 27 hours after the last imatinib administration. Complete cytogenetic response (CCyR), major molecular response (MMR) and complete molecular response (CMR) were used as metrics for efficacy. Nine single nucleotide polymorphisms in 5 genes, SLC22A4 (917 T>C, -248 C>G and -538 C>G), SLC22A5 (-945 T>G and -1889 T>C), SLCO1A2 (-361 G>A), SLCO1B3 (334 T>G and 699 G>A) and ABCG2 (421C>A) were selected for genotyping. Results: Patients with CCyR achieve higher trough concentrations than those without CCyR (1478.18±659.83 vs 984.89±454.06 ng mL-1, p<0.001). Patients with MMR and CMR achieve higher trough concentrations than those without MMR and CMR, respectively (1486.40±703.38 vs 1121.17±527.14 ng mL-1, p=0.007; 1528.00±709.98 vs 1112.67±518.35 ng mL-1, p=0.003, respectively). Carriers of A allele in SLCO1A2 -361G>A achieve higher CCyR and MMR rates (p=0.047, OR=4.320, 95% CI: 0.924-20.206; p=0.042, OR=2.825, 95% CI: 1.016-7.853, respectively). Both trough concentrations and SLCO1A2 -361G>A genotypes are independent factors affecting imatinib efficacy. The positive and negative predictive values for CCyR are 71.01% and 68.75%, respectively. The positive and negative predictive values for MMR are 62.86% and 69.70%, respectively. Conclusion: Imatinib trough concentrations and SLCO1A2 -361G>A genotypes are associated with imatinib efficacy in Chinese patients with CML. Keywords: Efficacy, Imatinib, Polymorphisms, Trough concentration

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& Al-Barzinji, Ahmed. "COMPARATIVE STUDY OF HATCHABILITY AND FERTILITY RATE AMONG LOCAL QUAILS." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 51, no. 3 (2020): 744–51. http://dx.doi.org/10.36103/ijas.v51i3.1028.

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An experiment was conducted to evaluate fertility, hatchability, egg weight and egg production traits from three different lines of local quails. A total number of 945 eggs (334, 321 and 290 for desert, brown and white, respectively), from 20 weeks of age were used in the study. White quail significantly (P≤0.05) produce higher egg weight (12.79 ± 0.08 g), chicks' weight (8.89± 0.02 g), percentage of mortality (2.34 ± 0.70 %) and Hen-day egg production (79.33 ± 0.98 %) comparing with other local quails. While local brown quail have significantly (P≤0.05) higher percentages of fertility and hatchability which averaged 79.11 and 86.80%, respectively. The higher total number of egg and low mortality percentage (0.93 ± 0.40 %) were recorded for desert local quail. The significant positive correlation (P≤0.001) were observed between the eggs weight and chick weight, fertility and hatchability, eggs weight and hatchability were arrived 0.276, 0.180 and 0.872, respectively. But non significant negative correlation recorded between chick weight with both of fertility and hatchability. These results show that there are good among of variance in performance production among different local quails, its means the selection process among these types of bird can play major role to speed up and increasing the economical traits of local quail in Iraqi Kurdistan region.

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Rivera-Sanchez, Y. M., R. A. Johnston, I. N. Schwartzman, et al. "Differential effects of ozone on airway and tissue mechanics in obese mice." Journal of Applied Physiology 96, no. 6 (2004): 2200–2206. http://dx.doi.org/10.1152/japplphysiol.00960.2003.

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Obesity is an important risk factor for asthma. We recently reported increased ozone (O3)-induced hyperresponsiveness to methacholine in obese mice (Shore SA, Rivera-Sanchez YM, Schwartzman IN, and Johnston RA. J Appl Physiol 95: 938–945, 2003). The purpose of this study was to determine whether this increased hyperresponsiveness is the result of changes in the airways, the lung tissue, or both. To that end, we examined the effect of O3 (2 parts/million for 3 h) on methacholine-induced changes in lung mechanics with the use of a forced oscillation technique in wild-type C57BL/6J mice and mice obese because of a genetic deficiency in leptin ( ob/ob mice). In ob/ob mice, O3 increased baseline values for all parameters measured in the study: airway resistance (Raw), lung tissue resistance (Rtis), lung tissue damping (G) and elastance (H), and lung hysteresivity (η). In contrast, no effect of O3 on baseline mechanics was observed in wild-type mice. O3 exposure significantly increased Raw, Rtis, lung resistance (Rl), G, H, and η responses to methacholine in both groups of mice. For G, Rtis, and Rl there was a significant effect of obesity on the response to O3. Our results demonstrate that both airways and lung tissue contribute to the hyperresponsiveness that occurs after O3 exposure in wild-type mice. Our results also demonstrate that changes in the lung tissue rather than the airways account for the amplification of O3-induced hyperresponsiveness observed in obese mice.

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Chayen, J. "Flavins and flavoproteins 1990. B. Curti, S. Ronchi and G. Zanetti (eds). de Gruyter, Berlin and New York. xxiii + 945 pages, DM390 (1991)." Cell Biochemistry and Function 10, no. 1 (1992): 68. http://dx.doi.org/10.1002/cbf.290100117.

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Röth, J. "SCHLECHTER, R., Die Orchideen/hrsg. von F. G. BRIEGER; P. MAATSCH; G. SENGHAS, 3. völlig neubearb. Aufl. Bd. I, 16–18. Lfg. S. 945–1128. Verlag Paul Parey, Berlin, Hamburg, 1983, 1985." Feddes Repertorium 103, no. 1-2 (1992): 34. http://dx.doi.org/10.1002/fedr.4921030105.

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Röth, J. "SCHLECHTER, R., Die Orchideen/hrsg. von F. G. BRIEGER; P. MAATSCH; G. SENGHAS, 3. völlig neubearb. Aufl. Bd. I, 16-18. Lfg. S. 945-1128. Verlag Paul Parey, Berlin, Hamburg, 1983, 1985." Feddes Repertorium 103, no. 1-2 (2008): 34. http://dx.doi.org/10.1002/fedr.19921030105.

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Patel, Sheila K., Bryan Wai, Richard J. MacIsaac, et al. "603 THE CTGF GENE -945 G/C POLYMORPHISM IS NOT ASSOCIATED WITH ECHOCARDIOGRAPHICALLY DETERMINED CARDIAC DISEASE OR CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES." Journal of Hypertension 30 (September 2012): e176-e177. http://dx.doi.org/10.1097/01.hjh.0000420625.80805.2e.

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Hocking, P. J. "Seasonal dynamics of production, and nutrient accumulation and cycling by Phragmites asutralis (Cav.) Trin. ex Stuedel in a nutrient-enriched swamp in Inland Australia. I. Whole Plants." Marine and Freshwater Research 40, no. 5 (1989): 421. http://dx.doi.org/10.1071/mf9890421.

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A study was made of the seasonal changes in dry matter production and patterns of nutrient accumulation by Phragmites australis in a nutrient-enriched swamp in inland Australia. The density of live shoots was highest (224 m-2) in October, but the peak standing crop of live shoots (9890 g m-2) occurred in early May. Peak below-ground biomass (21 058 g m-2) occurred in early August. Rhizome biomass constituted 75% of the below-ground biomass, and showed a distinct seasonal pattern. Net annual above-ground primary production (NAAP), estimated by the maximum-minimum method, was 9513 g m-2. Correction for shoot mortality and leaf shedding before, and production after, the maximum standing crop was attained increased NAAP to 12 898 g m-2. Whole plant production estimated by the maximum-minimum method was 9960 g m-2, and the corrected estimate was 14 945 g m-2. A model of dry-matter production indicated that translocation of carbohydrate from rhizomes could have provided 33% of the dry matter of shoots. About 23% of the dry matter of shoots was redistributed to below-ground organs during senescence. Concentrations of N, P, K, S, Cl and Cu declined, but concentrations of Ca, Mg, Na, Fe and Mn increased as shoots aged. Concentrations of N, P and Zn in rhizomes reached maxima in winter, and decreased in spring. Rhizomes usually contained the greatest quantity of a nutrient in the whole plant, and roots usually had less than 25% of the total plant content. There were seasonal fluctuations in the quantities of N, P, K, Zn and Cu in rhizomes. Nutrient accumulation by live shoots was underestimated by 22-55% using the maximum-minimum method. Nutrient budgets showed considerable internal cycling of N, P, K, S and Cu from rhizomes to developing shoots in spring, and from senescing shoots to rhizomes during autumn and winter.

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Golubtsov, A. V., E. V. Mikhailov, S. N. Semenov, I. O. Krutov, and V. N. Yakimenko. "The effect of the BACELL-M® probiotic feed additive on Big-6 turkeys." BIO Web of Conferences 126 (2024): 01029. http://dx.doi.org/10.1051/bioconf/202412601029.

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In this study, we evaluated the effectiveness of the probiotic supplement BACELL-M® when added to the diet of Big-6 turkeys. This supplement contains prebiotics and strains of Bacillus subtilis 945 (B-5225), Lactobacillus paracasei (B-2347), and Enterococcus faecium M-3185 (B-3491). For this study, the turkeys were divided into two groups based on the paired-analog principle, with five individuals in each group. Group 1 received the feed additive BACELL-M® at a dose of 10 g per 1 kg of feed added to their main diet. Group 2 served as the control. The weight gain dynamics for each group were assessed daily. On the 40th day, blood samples were taken to evaluate biochemical parameters. After slaughter, samples of the large intestine were collected for morphological studies. The experimental group showed superior results according to the studied criteria compared to the control group. The results also indicated increased meat productivity in the turkeys supplemented with BACELLM ®. This suggests the potential of using this dietary supplement as a preventive measure against gastrointestinal dsiseases in turkeys.

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Brownbill, Aimee L., Caroline L. Miller, and Annette J. Braunack-Mayer. "Industry use of ‘better-for-you’ features on labels of sugar-containing beverages." Public Health Nutrition 21, no. 18 (2018): 3335–43. http://dx.doi.org/10.1017/s1368980018002392.

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AbstractObjectiveTo examine the ways in which sugar-containing beverages are being portrayed as ‘better-for-you’ (BFY) via features on product labels.DesignCross-sectional audit of beverage labels.SettingAdelaide, Australia. Data on beverage labels were collected from seventeen grocery stores during September to November 2016.SubjectsThe content of 945 sugar-containing beverages labels were analysed for explicit and implicit features positioning them as healthy or BFY.ResultsThe mean sugar content of beverages was high at 8·3 g/100 ml and most sugar-containing beverages (87·7 %) displayed features that position them as BFY. This was most commonly achieved by indicating the beverages are natural (76·8 %), or contain reduced or natural energy/sugar content (48·4 %), or through suggesting that they contribute to meeting bodily needs for nutrition (28·9 %) or health (15·1 %). Features positioning beverages as BFY were more common among certain categories of beverages, namely coconut waters, iced teas, sports drinks and juices.ConclusionsA large proportion of sugar-containing beverages use features on labels that position them as healthy or BFY despite containing high amounts of sugar.

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Galeano-Díaz, Johana Paola, Juan Edrei Sánchez-Torres, Ignacio Arturo Domínguez-Vara, et al. "Effects on Growth Performance Parameters, Carcass Traits, Meat Nutrimental Quality and Intramuscular Fatty Acid Profile of Rabbits Fed with Diets with Avocado Waste (Persea americana Mill)." Agriculture 13, no. 3 (2023): 549. http://dx.doi.org/10.3390/agriculture13030549.

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The objective of this paper was to evaluate the effect of four levels (0%, 4.32%, 8.39% or 12.25%) of avocado waste (AW) included in the diets on productive performance, carcass characteristics and meat nutritional quality of fattening rabbits. For that, one hundred and twenty male rabbits (New Zealand × California; 945 ± 47 g initial body weight) were fed over 28 days, randomly distributed to one of the four treatments (T) (T1 = 0, T2 = 4.32, T3 = 8.39 and T4 = 12.25% AW as fed). The chemical and fatty acids profiles were evaluated in the Longissimus thoracis et lumborum (LTL) muscle. The rabbits fed with 8.39% of AW reported the best productive parameters (p < 0.05), the greater (p < 0.05) dissectible adipose tissue and higher polyunsaturated fatty acids (PUFAs) n-3 content (p < 0.05) than control meat. It is concluded that the inclusion of AW in the growing–finishing rabbit’s diet can modify the nutritional quality of the meat, reducing the n-6/n-3 ratio and the thrombogenic index.

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Le, Tran Uyen Tu. "Effects of Sb on structure, micro structure and electrical characteristics of Sb-modified (K0.41Na0.59)NbO3 ceramics." Hue University Journal of Science: Natural Science 132, no. 1D (2023): 35–42. http://dx.doi.org/10.26459/hueunijns.v132i1d.7160.

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Lead-free (Na0.59K0.41)(Nb1-xSbx)O3 ceramic (x = 0 ÷ 0.12) were prepared by the solid phase reaction method. The influence of Sb concentration on the structure, microstructure and electrical properties of the ceramic was studied. Results indicate that the presence of pure perovskite phase was revealed by XRD patterns recorded for the ceramics, which also showed a shift in structure from orthorhombic to mixed rhombohedral and tetragonal with an increase in x value. At x = 0.06, the ceramics express the best microstructure, the particles were tightly packed with an average particle size of 1.76 µm. The (Na0,59K0,41)(Nb0,94Sb0,06)O3 ceramics have the best dielectric and ferroelectric properties: the ceramic density (r) is 4.48 g/cm3 (relative density: 98.7% of the theoretical value); highest dielectric constant at TC (emax) of 12031; dielectric constant at RT (ε) of 945; low dielectric loss (tanδ) of 0.15; and high remanent polarization (Pr) of 11,2 mC/cm2; and the reactance field (Ec) of 8.7 kV/cm, and the phase transition temperatures (TC) of 372 °C, and (TO-T) of 157 °C.

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Farhang, Hamid, Laleh Sharifi, Mohammad Mehdi Soltan Dallal, et al. "The Immunomodulatory Role of G2013 (α-L-Guluronic Acid) on the Expression of TLR2 and TLR4 in HT29 cell line." Current Drug Discovery Technologies 16, no. 1 (2019): 91–95. http://dx.doi.org/10.2174/1570163815666180226093711.

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Background: The non-steroidal anti-inflammatory drugs (NSAIDs) play crucial role in the controlling of inflammatory diseases. Due to the vast side effects of NSAIDs, its use is limited. G2013 or &amp;#945;-L-Guluronic Acid is a new NSAID with immunomodulatory features. Objectives: Considering the leading role of TLRs in inflammatory responses, in this study, we aimed to evaluate G2013 cytotoxicity and its effect on the expression of TLR2 and TLR4 molecules. Methods: HEK293-TLR2 and HEK293-TLR4 cells were cultured and seeded on 96-well cell plate, and MTT assay was performed for detecting the viability of the cells after treatment with different concentrations of G2013. HT29 cells were grown and treated with low and high doses of G2013. After total RNA extraction and cDNA synthesis, quantitative real-time PCR were performed to assess the TLR2 and TLR4 mRNA synthesis. Results: We found that concentrations of ≤125 &amp;#181;g/ml of G2013 had no apparent cytotoxicity effect on the HEK293-TLR2 and -TLR4 cells. Our results indicated that after G2013 treatment (5 &amp;#181;g/ml) in HT29 cells, TLR2 and TLR4 mRNA expression decreased significantly compared with the untreated control group (p=0.02 and p=0.001 respectively). Conclusion: The results of this study revealed that G2013 can down regulate the TLR2 and TLR4 gene expression and exerts its inhibitory effect. Our findings are parallel to our previous finding which showed G2013 ability to down regulate the signaling pathway of TLRs. However, further studies are needed to identify the molecular mechanism of G2013.<p&gt;

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Gupta, Umesh C., and Subhas C. Gupta. "The Important Role of Potatoes, An Underrated Vegetable Food Crop in Human Health and Nutrition." Current Nutrition & Food Science 15, no. 1 (2019): 11–19. http://dx.doi.org/10.2174/1573401314666180906113417.

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Despite frequently being described as a carbohydrate-laden, calorie-rich unimportant part of the human diet, potatoes (Solanum tuberosum L.) are one of the most nutritive vegetable food crops in the world and, in comparison to most other vegetables are richer in essential human nutrients. These include proteins, starch and fibre, major, secondary and trace minerals, vitamins, antioxidants and phytochemicals. Potatoes have an abundance of vitamin C and the mineral potassium (K) which are vital for health. Potassium reduces the risk of Blood Pressure (BP), cardiovascular diseases (CVDs), osteoporosis and strokes. Vitamin C helps reduce strokes and hypertension and prevents scurvy. The predominant form of carbohydrate (CHO) in the potato is starch. A small but significant part of this starch is resistant to digestion by enzymes in the stomach and small intestine, so it reaches the large intestine essentially intact. This resistant starch is considered to have similar physiological effects and health benefits as fibre. A medium size potato (148 g) contains 4 g protein and very small amount of fat or cholesterol. The fibre content of a potato with skin is equivalent to that of many whole grain breads and pastas. Potatoes contain rather large amount of the enzyme catalase, which converts hydrogen peroxide into oxygen and water and thus prevents cell injury. Potatoes contain phytochemicals such as lutein and zeaxanthin; which protect and preserve eyesight and may help reduce the risk of macular degeneration. It is not the high Glycemic Index (GI) in potatoes or in any other food, but the number of calories consumed from all foods that causes weight gain. Overall, potatoes are an underrated source of essential human nutrients. Potatoes also contain toxic compounds, such as &#945;-solanine and &#945;-chaconine which are known to induce toxicity. These poisons cause gastrointestinal disturbances causing vomiting and diarrhea but severe poisoning may lead to paralysis, cardiac failure and comma. Green areas in potatoes containing chlorophyll are harmless but indicate that toxins may be present. According to the American Cancer Society, food born toxin such as acrylamide is formed when starchy foods such as potatoes and potato products are cooked at temperatures above 121C. However, deep frying at 170C is known to effectively lower the level of toxic compounds, while microwaving is only somewhat effective and freezedrying or dehydration has little effect. The highest levels of acrylamide are found in CHO-rich foods, such as potato chips and French fries, which had been cooked at high temperatures.

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Aloliqi, Abdulaziz A. "Therapeutic Potential of 6-Gingerol in Prevention of Colon Cancer Induced by Azoxymethane through the Modulation of Antioxidant Potential and Inflammation." Current Issues in Molecular Biology 44, no. 12 (2022): 6218–28. http://dx.doi.org/10.3390/cimb44120424.

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A polyphenolic component of ginger, 6-gingerol, is widely reported to possess antioxidant, anti-inflammatory and anticancer activities. In the current study, it was aimed to investigate the anticancer effects of 6-gingerol (6-Gin) on azoxymethane (AOM)-induced colon cancer in rats. The results reveal that 6-Gin treatment significantly improves the antioxidant status disturbed by AOM intoxication. The 6-Gin treatment animal group showed enhanced activity of catalase (CAT) (46.6 ± 6.4 vs. 23.3 ± 4.3 U/mg protein), superoxide dismutase (SOD) (81.3 ± 7.6 vs. 60.4 ± 3.5 U/mg protein) and glutathione-S-transferase (GST) (90.3 ± 9.4 vs 53.8 ± 10 mU/mg protein) (p < 0.05) as compared to the disease control group. Furthermore, the results reveal that AOM significantly enhances the inflammatory response and 6-gingerol potentially attenuates this response, estimated by markers, such as tumor necrosis factor-α (TNF-α) (1346 ± 67 vs. 1023 ± 58 pg/g), C-reactive protein (CRP) (1.12 ± 0.08 vs. 0.92 ± 0.7 ng/mL) and interleukin-6 (IL-6) (945 ± 67 vs. 653 ± 33 pg/g). In addition, the lipid peroxidation estimated in terms of malondialdehyde (MDA) provoked by AOM exposure is significantly reduced by 6-gingerol treatment (167 ± 7.5 vs. 128.3 nmol/g). Furthermore, 6-gingerol significantly maintains the colon tissue architecture disturbed by the AOM treatment. Loss of tumor suppressor protein, phosphatase and tensin homolog (PTEN) expression was noticed in the AOM treated group, whereas in the animals treated with 6-gingerol, the positivity of PTEN expression was high. In conclusion, the current findings advocate the health-promoting effects of 6-gingerol on colon cancer, which might be due to its antioxidant and anti-inflammatory potential.

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Douglas, Steve M., Tyler R. Lasley, and Heather J. Leidy. "Consuming Beef vs. Soy Protein Has Little Effect on Appetite, Satiety, and Food Intake in Healthy Adults." Journal of Nutrition 145, no. 5 (2015): 1010–16. http://dx.doi.org/10.3945/jn.114.206987.

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Abstract Background: Although protein-rich plant foods have recently been touted as an equivalent to animal products, limited data exist regarding the effects of animal vs. plant proteins on appetite, satiety, and subsequent food intake. Objective: The objective was to determine whether a high-protein beef lunch alters the appetitive, hormonal, and neural signals controlling food intake regulation vs. a macronutrient and fiber–matched (MF) or serving size–matched (SS) soy lunch in healthy adults. Methods: A randomized, double-blind, crossover design study was completed in 21 adults (aged 23 ± 1 y; body mass index: 23.8 ± 0.6 kg/m2; mean ± SEM) to compare 400-kcal MF and SS lunches varying in protein quality. The MF lunches contained 24-g beef protein or 24-g soy protein, whereas the SS lunches contained 1 serving of beef (24-g protein/1-g fiber) or soy (14-g protein/5-g fiber). Pre- and postlunch appetite questionnaires and blood sampling were completed over an 8-h period until dinner was voluntarily requested. In addition, pre- and postlunch functional MRI brain scans were completed to assess neural activation in response to food stimuli. Results: On average, dinner was requested at ∼250 ± 20 min postlunch with no differences between beef vs. soy within the MF and SS conditions. Furthermore, no differences in hunger, fullness, peptide YY, or glucagon-like peptide-1 responses were observed after the beef vs. soy lunches within the MF and SS conditions. The SS beef meal led to reductions in anterior cingulate activation (−22 ± 6%) vs. soy (+7 ± 9%;P &lt; 0.01) and greater reductions in insular activation (−30 ± 6%) vs. SS soy (−7 ± 10%;P &lt; 0.01). The participants consumed ∼945 ± 78 kcal after the MF meals and 910 ± 74 kcal after the SS meals with no differences between beef vs. soy. Conclusions: When comparing 2 high-quality protein sources, such as beef and soy, the type of protein consumed within a mixed meal elicited very little effect on appetite, satiety, and food intake in healthy adults. This study was registered atclinicaltrials.gov as NCT02285907.

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Paula, Weslla Karla Albuquerque Silva de, Maria de Fátima Costa Caminha, José Natal Figueirôa, and Malaquias Batista Filho. "Anemia e deficiência de vitamina A em crianças menores de cinco anos assistidas pela Estratégia Saúde da Família no Estado de Pernambuco, Brasil." Ciência & Saúde Coletiva 19, no. 4 (2014): 1209–22. http://dx.doi.org/10.1590/1413-81232014194.00602013.

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O objetivo do presente estudo foi descrever a prevalência e os fatores associados à anemia e à deficiência de vitamina A (DVA) em crianças menores de cinco anos assistidas pela Estratégia Saúde da Família. Estudo transversal, realizado em Pernambuco, Brasil, em 2006. Foram selecionadas crianças entre 6 e 59 meses de idade, que tiveram realizadas dosagens de hemoglobina e retinol sérico, perfazendo amostras de 945 e 563 crianças respectivamente. A presença de anemia foi determinada pelo nível de hemoglobina < 11 g/dL e DVA pelo nível de retinol sérico < 0,70 μmol/L. Realizaram-se análises univariada e ajustada por regressão múltipla de Poisson, utilizando modelo hierarquizado. A prevalência de anemia foi de 35%, diminuindo com o aumento do número de pessoas por cômodo, idade materna e idade da criança. No que concerne à DVA, sua prevalência foi de 16%, aumentando em locais onde o destino do lixo era inadequado e em crianças que apresentaram diarreia nos últimos quinze dias. A prevalência de anemia foi maior que o dobro encontrada para a DVA, chamando atenção a influência dos fatores ambientais sobre a DVA.

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Valencia, Elide, and Francisco Rivera. "Voluntary intake and digestibility of lambs fed hay of forage soybeans cv. ‘Rongai’ [Lablab purpureus (L.) Sweet]." Journal of Agriculture of the University of Puerto Rico 107, no. 1 (2023): 1–10. http://dx.doi.org/10.46429/jaupr.v107i1.21219.

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Sun cured hays of two legumes, forage soybean (Glycine max L. Merr.) cv. ‘Hinson Long Juvenile’ and Lablab [Lablab purpureus (L.) Sweet] cv. ‘Rongai’, were compared in terms of voluntary intake and digestibility of dry matter (DM), crude protein, and neutral detergent fiber, in six individually caged lambs (28.4 ± 4 kg body weight). Treatments were arranged in a completely randomized design with three replicates (animals). The lambs were fed periodically during a seven-day adaptation period, and data collection was carried out over five days. ‘Hinson’ and ‘Rongai’ did not differ in crude protein (15.8 vs. 15.5%) and neutral detergent fiber (56.2 vs. 55.1% of DM). Lambs fed cv. ‘Hinson’ consumed more DM (P<0.05) than those fed ‘Rongai’ (945 vs. 853 g/d). ‘Hinson’ also registered higher DM digestibility (56.2 vs. 49.6%) than ‘Rongai’. Based on their agronomic characteristics, chemical composition, voluntary intake, and digestibility, both legumes exhibit good potential for use as hay. Large-scale planting of these legumes could supply hay for ruminant feeding to supplement low quality tropical grasses and reduce the need for imported protein sources for ruminant feeding.

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Shymanets, Aliaksei, Mohammad Ahmadian, and Bernd Nurnberg. "Gβγ-Copurified Lipid Kinase Impurity from Sf9 Cells." Protein & Peptide Letters 16, no. 9 (2009): 1053–56. http://dx.doi.org/10.2174/092986609789055340.

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Shingfield, K. J., and N. W. Offer. "Evaluation of milk allantoin excretion as an index of microbial protein supply in lactating dairy cows." Animal Science 67, no. 3 (1998): 371–85. http://dx.doi.org/10.1017/s135772980003277x.

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AbstractThe potential of milk allantoin as an index ofmicrobial protein supply was evaluated in two experiments conducted with 12 multiparous Holstein-Friesian dairy cows that examined the effects of altering the supply of metabolizable energy (ME) and fermentable metabolizable energy (FME). In the first experiment, late lactation cows received a 14·3 kg dry matter (DM) per day basal diet consisting of (g/kg DM) chopped barley straw (415), soya-bean meal (322), molassed sugar-beet pulp (197), molasses (33), urea (17) and a vitamin and mineral supplement (17) for a 21-day co-variance period. During four 16-day periods, six treatments were allocated randomly to cows, consisting of potato starch (1, 2 or 3 kg DM per day) or fat supplements (0·64, 1·27 or 1·91 kg DM per day). In the second experiment, early lactation cows received 40 kg/day (fresh weight, (FW)) of silage (307 g/kg toluene-corrected dry matter, 149 g/kg DM crude protein and 11·6 MJ/kg ME). During three 21-day periods, four treatments were evaluated consisting of supplements of either 4·1 (LI) or 8·1 (12) kg fresh weight per day of a low fat concentrate (acid hydrolysis ether extract (AHEE) 45 g/kg DM) or 3·8 (HI) or 7·5 (H2) kg fresh weight per day of a high fat concentrate (AHEE 110 g/kg DM). Both experiments showed individual cow milk allantoin concentration or excretion to be poorly correlated with urinary purine derivative excretion or calculated microbial protein supply. Use of treatment mean (TM) values dramatically improved these relationships. For pooled TM (no. = 10) values from both experiments, close relationships existed between milk allantoin excretion and concentration with milk yield (r values 0·991 and 0·883, respectively). Auto-correlation with milk yield appeared to account for milk allantoin excretion and concentration being highly correlated with urinary purine derivative excretion (r values 0·908 and 0·934, respectively) and calculated microbial protein supply (r values 0·938 and 0·945, respectively). Current experimental data indicates that measurement of milk allantoin is not a reliable indicator of microbial protein supply for individual cows.

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Neves, João Sérgio, Simon Correa, Rute Baeta Baptista, Miguel Bigotte Vieira, Sushrut S. Waikar, and Finnian R. Mc Causland. "Association of Prediabetes With CKD Progression and Adverse Cardiovascular Outcomes: An Analysis of the CRIC Study." Journal of Clinical Endocrinology & Metabolism 105, no. 4 (2020): e1772-e1780. http://dx.doi.org/10.1210/clinem/dgaa017.

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Abstract Purpose Despite our understanding of diabetes as an established risk factor for progressive kidney disease and cardiac complications, the prognostic significance of prediabetes in patients with chronic kidney disease (CKD) remains largely unknown. Methods Participants of the Chronic Renal Insufficiency Cohort (CRIC) were categorized as having normoglycemia, prediabetes, or diabetes according to fasting plasma glucose, glycated hemoglobin A1c (HbA1c), and treatment with antidiabetic drugs at baseline. Unadjusted and adjusted proportional hazards models were fit to estimate the association of prediabetes and diabetes (versus normoglycemia) with: (1) composite renal outcome (end-stage renal disease, 50% decline in estimated glomerular filtration rate to ≤ 15 mL/min/1.73 m2, or doubling of urine protein-to-creatinine ratio to ≥ 0.22 g/g creatinine); (2) composite cardiovascular (CV) outcome (congestive heart failure, myocardial infarction or stroke); and (3) all-cause mortality. Results Of the 3701 individuals analyzed, 945 were normoglycemic, 847 had prediabetes and 1909 had diabetes. The median follow-up was 7.5 years. Prediabetes was not associated with the composite renal outcome (adjusted hazard ratio [aHR] 1.13; 95% confidence interval [CI], 0.96–1.32; P = 0.14), but was associated with proteinuria progression (aHR 1.23; 95% CI, 1.03–1.47; P = 0.02). Prediabetes was associated with a higher risk of the composite CV outcome (aHR 1.38; 95% CI, 1.05–1.82; P = 0.02) and a trend towards all-cause mortality (aHR 1.28; 95% CI, 0.99–1.66; P = 0.07). Participants with diabetes had an increased risk of the composite renal outcome, the composite CV outcome, and all-cause mortality. Conclusions In individuals with CKD, prediabetes was not associated with composite renal outcome, but was associated with an increased risk of proteinuria progression and adverse CV outcomes.

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