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Journal articles on the topic 'G-Hedgehog'

Author: Grafiati

Published: 18 May 2024

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1

Gomes-Gonçalves, Sara, Sérgio Santos-Silva, Andreia V. S. Cruz, et al. "A Thorny Tale of Parasites: Screening for Enteric Protozoan Parasites in Hedgehogs from Portugal." Animals 14, no. 2 (2024): 326. http://dx.doi.org/10.3390/ani14020326.

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Enteric protozoan parasites, such as Blastocystis sp., Balantioides coli, Cryptosporidium spp., and Giardia duodenalis, may have implications for both animal and human health.Transmitted through the fecal–oral route, these parasites cause symptoms such as diarrhea, abdominal pain, and weight loss. This study investigated the presence of these enteric protozoan parasites and genetically characterized them in hedgehogs from Portugal. A total of 110 hedgehog stool samples were collected. Molecular detection methods showed an overall occurrence of protozoa in 1.82% (2/110 95% CI: 0.22–6.41) of hed

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2

Khera, Himanshi, Anupam Awasthi, and Sidharth Mehan. "Sonic Hedgehog Signaling Activation Promotes Cardioprotective Strategies." Current Signal Transduction Therapy 15, no. 2 (2020): 197–204. http://dx.doi.org/10.2174/1574362413666181113124958.

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Background: Hedgehog pathway plays a crucial role in the neovascularisation and angiogenesis during the embryonic stage in humans. Three genes of hedgehog protein isolated from humans are Sonic hedgehog, Desert hedgehog and Indian hedgehog gene. Two G-protein coupled receptors identified in the sonic hedgehog pathway served as patched receptor and smoothened receptor. Materials and Methods: Particularly, sonic hedgehog gene plays a versatile role in cellular homeostasis and can be a novel therapeutic target in the prevention of cardiovascular disorders. Further various sonic hedgehog modulator

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Rasmussen, Sophie Lund, Ane Elise Schrøder, Ronja Mathiesen, Jeppe Lund Nielsen, Cino Pertoldi, and David W. Macdonald. "Wildlife Conservation at a Garden Level: The Effect of Robotic Lawn Mowers on European Hedgehogs (Erinaceus europaeus)." Animals 11, no. 5 (2021): 1191. http://dx.doi.org/10.3390/ani11051191.

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We tested the effects of 18 models of robotic lawn mowers in collision with dead European hedgehogs and quantified the results into six damage categories. All models were tested on four weight classes of hedgehogs, each placed in three different positions. None of the robotic lawn mowers tested was able to detect the presence of dependent juvenile hedgehogs (<200 g) and all models had to touch the hedgehogs to detect them. Some models caused extensive damage to the hedgehog cadavers, but there were noteworthy differences in the degree of harm inflicted, with some consistently causing no dam

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Budiono, Novericko Ginger, Nicole Ting Qian Wen, Punithe Raj A/L Rajendran, and Annise Proboningrat. "Speedy Recovery of Subcutaneous Abscess and The Presence of Overgrown Nails in A Pygmy Hedgehog: A Case Report." Jurnal Medik Veteriner 6, no. 3 (2023): 126–35. http://dx.doi.org/10.20473/jmv.vol6.iss3.2023.126-135.

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This study reported that a 15-month-old intact female African pygmy hedgehog (Atelerix albiventris) was presented to IPB University Veterinary Teaching Hospital to evaluate a 1.5 cm × 1.5 cm × 0.5 cm mass on the left ventral thorax, three days after the mass was first discovered by the owner. Overgrown nails were observed on all four toes of each of the four limbs of the hedgehog. The body weight was 150 g, and the axial temperature was 36.5°C. The heart and respiratory rates were 180 per minute and 40 per minute, respectively. After a thorough physical examination, the patient was diagnosed w

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5

Mukhopadhyay, Saikat, and Rajat Rohatgi. "G-protein-coupled receptors, Hedgehog signaling and primary cilia." Seminars in Cell & Developmental Biology 33 (September 2014): 63–72. http://dx.doi.org/10.1016/j.semcdb.2014.05.002.

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6

Philipp, Melanie, and Marc G. Caron. "Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?" Current Biology 19, no. 3 (2009): R125—R127. http://dx.doi.org/10.1016/j.cub.2008.12.010.

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7

Philipp, Melanie, Gregory B. Fralish, Alison R. Meloni, et al. "Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase." Molecular Biology of the Cell 19, no. 12 (2008): 5478–89. http://dx.doi.org/10.1091/mbc.e08-05-0448.

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Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from Drosophila to vertebrates. Given its molecular architecture, Smoothened signaling is likely to be regulated in a manner analogous to G protein–coupled receptors (GPCRs). Previously, it has been shown, that arrestins and GPCR kinases, (GRKs) not only des

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8

Norris, W., C. Neyt, P. W. Ingham, and P. D. Currie. "Slow muscle induction by Hedgehog signalling in vitro." Journal of Cell Science 113, no. 15 (2000): 2695–703. http://dx.doi.org/10.1242/jcs.113.15.2695.

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Muscles are composed of several fibre types, the precise combination of which determines muscle function. Whereas neonatal and adult fibre type is influenced by a number of extrinsic factors, such as neural input and muscle load, there is little knowledge of how muscle cells are initially determined in the early embryo. In the zebrafish, fibres of the slow twitch class arise from precociously specified myoblasts that lie close to the midline whereas the remainder of the myotome differentiates as fast myosin expressing muscle. In vivo evidence has suggested the Sonic Hedgehog glycoprotein, secr

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9

Meloni, Alison R., Gregory B. Fralish, Patrick Kelly, et al. "Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2." Molecular and Cellular Biology 26, no. 20 (2006): 7550–60. http://dx.doi.org/10.1128/mcb.00546-06.

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ABSTRACT Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation and differentiation through activation of the transcription factor Gli. The activity of mammalian Smoothened is controlled by three different hedgehog proteins, Indian, Desert, and Sonic hedgehog, through their interaction with the Smoothened inhibitor Patched. However, the mechanisms of signal transduction from Smoothened are poorly understood. We show that a kinase which r

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10

Gvozdenovic-Jeremic, Jelena, and Ljiljana Mojovic. "Drug repositioning for a rare genetic disorder progressive osseous heteroplasia (POH)." Genetika 51, no. 1 (2019): 347–55. http://dx.doi.org/10.2298/gensr1901347g.

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Progressive osseous heteroplasia (POH) is an ultrarare genetic disease of progressive ectopic ossification caused by heterozygous inactivating mutations of GNAS, the gene encoding the alpha subunit of the G-stimulatory protein of adenylyl cyclase (Gs?). Extensive ossification of the deep connective tissues can result in ankylosis of affected joints and growth retardation of involved limbs. Inhibition of main molecular signaling, Hedgehog (Hh) pathway, by pharmacological methods may reduce the severity of ectopic bone formation in POH patients. Hh inhibitors currently used or known for other co

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11

Gounder, Mrinal M., Mark Andrew Dickson, Nian Wu, et al. "A first-in-human, phase Ib combination study to assess safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a hedgehog inhibitor, GDC-0449, with a Notch inhibitor, RO4929097, in patients with advanced sarcoma." Journal of Clinical Oncology 30, no. 15_suppl (2012): 10004. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10004.

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10004 Background: Aberrant Hedgehog and Notch signaling is seen in sarcoma and anti-tumor activity is enhanced by inhibiting both pathways. This first in man Phase Ib study evaluated safety and efficacy of the combination of GDC-0449 (G), a smoothened inhibitor with RO4929097 (R), a gamma-secretase/notch inhibitor. Methods: The study evaluated fixed dose G (150 mg qd) for 21 days followed by G + R at either 10 mg (level 1) or 15 mg (level 2) QD. At MTD pts were evaluated with G + R (without “lead in” G) or single agent R. Pre and post treatment tumor biopsies were obtained to assess notch and

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12

Moore, Bryn S., Ann N. Stepanchick, Paul H. Tewson, et al. "Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics." Proceedings of the National Academy of Sciences 113, no. 46 (2016): 13069–74. http://dx.doi.org/10.1073/pnas.1602393113.

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Protein kinase A (PKA) phosphorylates Gli proteins, acting as a negative regulator of the Hedgehog pathway. PKA was recently detected within the cilium, and PKA activity specifically in cilia regulates Gli processing. Using a cilia-targeted genetically encoded sensor, we found significant basal PKA activity. Using another targeted sensor, we measured basal ciliary cAMP that is fivefold higher than whole-cell cAMP. The elevated basal ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliary phosphatidylinositol (3,4,5)-trisphosphate (PIP3), not stimulatory G pr

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13

Igado, O. O., S. F. Braimah, and A. A. Obasa. "Gross Morphology of the Brain and Spinal Cord of the African Pygmy Hedgehog (Atelerix albiventris)." Folia Veterinaria 65, no. 3 (2021): 15–21. http://dx.doi.org/10.2478/fv-2021-0023.

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Abstract The African pygmy hedgehog (Atelerix albiventris) is an insectivorous animal, native to Africa. The central nervous system (CNS) consists of the brain and the spinal cord, protected by the cranium and vertebral column respectively. Assessment of the gross appearance and morphometries of the African pygmy hedgehog CNS were carried out using six adults (3 males and 3 females). The gross examination showed the brains to be lissencephalic, with relatively large olfactory bulbs, similar to that observed in some rodents. The rootlets of the first cervical spinal nerves were observed to emer

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14

He, Xuelian, та Q. Richard Lu. "G-Protein Gαs controls medulloblastoma initiation by suppressing sonic hedgehog signaling". Molecular & Cellular Oncology 2, № 2 (2014): e975070. http://dx.doi.org/10.4161/23723556.2014.975070.

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15

Ogden, Stacey K., Dennis Liang Fei, Neal S. Schilling, Yashi F. Ahmed, John Hwa та David J. Robbins. "G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling". Nature 456, № 7224 (2008): 967–70. http://dx.doi.org/10.1038/nature07459.

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16

Ayers, Katie L., and Pascal P. Thérond. "Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling." Trends in Cell Biology 20, no. 5 (2010): 287–98. http://dx.doi.org/10.1016/j.tcb.2010.02.002.

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17

Bearman-Brown, Lucy E., Philip J. Baker, Dawn Scott, Antonio Uzal, Luke Evans, and Richard W. Yarnell. "Over-Winter Survival and Nest Site Selection of the West-European Hedgehog (Erinaceus europaeus) in Arable Dominated Landscapes." Animals 10, no. 9 (2020): 1449. http://dx.doi.org/10.3390/ani10091449.

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The West-European hedgehog (Erinaceus europaeus) has declined markedly in the UK. The winter hibernation period may make hedgehogs vulnerable to anthropogenic habitat and climate changes. Therefore, we studied two contrasting populations in England to examine patterns of winter nest use, body mass changes and survival during hibernation. No between-site differences were evident in body mass prior to hibernation nor the number of winter nests used, but significant differences in overwinter mass change and survival were observed. Mass change did not, however, affect survival rates; all deaths oc

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18

Potuijt, Jacob W. P., Jeannette Hoogeboom, Esther de Graaff, Christianne A. van Nieuwenhoven, and Robert Jan H. Galjaard. "Variable expression of subclinical phenotypes instead of reduced penetrance in families with mild triphalangeal thumb phenotypes." Journal of Medical Genetics 57, no. 10 (2020): 660–63. http://dx.doi.org/10.1136/jmedgenet-2019-106685.

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BackgroundThe of zone of polarizing activity regulatory sequence (ZRS) is a regulatory element residing in intron 5 of LMBR1 and regulates Sonic Hedgehog expression in the limb bud. Variants in the ZRS are generally fully penetrant and can cause triphalangeal thumb (TPT) and polydactyly in affected families.ObjectiveIn this report, we describe two families with mild phenotypical presentation.MethodsWe performed a field study for clinical evaluation and sequenced the ZRS for variantsusing Sanger sequencing.ResultsIn family I, a novel 165A>G variant in the ZRS (g.156584405A>G, GRCh37/Hg19)

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19

Maier, Dominic, Shuofei Cheng, and David R. Hipfner. "The complexities of G-protein-coupled receptor kinase function in Hedgehog signaling." Fly 6, no. 3 (2012): 135–41. http://dx.doi.org/10.4161/fly.20245.

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20

Cheng, S., D. Maier, and D. R. Hipfner. "Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signalling." Journal of Cell Science 125, no. 1 (2012): e1-e1. http://dx.doi.org/10.1242/jcs.106047.

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21

Cheng, S., D. Maier, and D. R. Hipfner. "Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling." Development 139, no. 1 (2011): 85–94. http://dx.doi.org/10.1242/dev.068817.

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22

Zhao, Jia-wen, Feng-yang Chen, Li-juan Gao, Shi-fang Xu, Yi-ping Ye, and Xiao-yu Li. "Two New Steroidal Aglycones from Roots of Cynanchun Paniculatum." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100612.

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Two new 13, 14/14, 15-disecopregnane-type skeleton C21 steroidal aglycones, neocynapanogenin G (1) and neocynapanogenin H (2), were isolated from the hydrolyzed extract of the CHC13 soluble extract of the roots of Cynanchun paniculatum. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including ID and 2D NMR spectroscopy. Compound 1 displayed significant inhibition of the Hedgehog signaling pathway in vitro.

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Kasai, Kenji, Masanori Takahashi, Noriko Osumi, et al. "The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling." Genes to Cells 9, no. 1 (2004): 49–58. http://dx.doi.org/10.1111/j.1356-9597.2004.00701.x.

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Pusapati, Ganesh V., Jennifer H. Kong, Bhaven B. Patel, et al. "G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog." Science Signaling 11, no. 516 (2018): eaao5749. http://dx.doi.org/10.1126/scisignal.aao5749.

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Rao, Rohit, Ralph Salloum, Mei Xin та Q. Richard Lu. "The G protein Gαsacts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis". Cell Cycle 15, № 10 (2016): 1325–30. http://dx.doi.org/10.1080/15384101.2016.1164371.

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Mahoney, William M., Jagadambika Gunaje, Guenter Daum, Xiu Rong Dong, and Mark W. Majesky. "Regulator of G-Protein Signaling – 5 (RGS5) Is a Novel Repressor of Hedgehog Signaling." PLoS ONE 8, no. 4 (2013): e61421. http://dx.doi.org/10.1371/journal.pone.0061421.

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Molnar, C., H. Holguin, F. Mayor, A. Ruiz-Gomez, and J. F. de Celis. "The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila." Proceedings of the National Academy of Sciences 104, no. 19 (2007): 7963–68. http://dx.doi.org/10.1073/pnas.0702374104.

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Del Giovane, Alice, and Antonella Ragnini-Wilson. "Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies." International Journal of Molecular Sciences 19, no. 11 (2018): 3677. http://dx.doi.org/10.3390/ijms19113677.

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Myelin sheaths on vertebrate axons provide protection, vital support and increase the speed of neuronal signals. Myelin degeneration can be caused by viral, autoimmune or genetic diseases. Remyelination is a natural process that restores the myelin sheath and, consequently, neuronal function after a demyelination event, preventing neurodegeneration and thereby neuron functional loss. Pharmacological approaches to remyelination represent a promising new frontier in the therapy of human demyelination pathologies and might provide novel tools to improve adaptive myelination in aged individuals. R

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Gudrun Kalmbach HE. "Dynamical interaction geometries for physics with models." Magna Scientia Advanced Research and Reviews 1, no. 2 (2021): 031–37. http://dx.doi.org/10.30574/msarr.2021.1.2.0007.

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The MINT-Wigris Tool bag is presented with its models for color charges as a G-compass the hedgehog for the energy exchange of a nucleon system with its environment, an inner quark-gluon flow in it as 6-roll mill, two nucleon tetrahedrons for the gluon exchange between nucleons quarks, a radial contraction/expansion pulsation for deuteron, two fusion states of the tetrahedrons, a neutrino Gleason operator bound geometry and oscillation dynamics.

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Jiang, Weirong, Xia Yao, Zhaoliang Shan, Wenting Li, Yuxue Gao, and Qing Zhang. "E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation." Journal of Molecular Cell Biology 11, no. 9 (2019): 791–803. http://dx.doi.org/10.1093/jmcb/mjz024.

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Abstract Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose posttranslational regulation has been shown to be critical for its accumulation and activation. Ubiquitination has been reported an essential posttranslational regulation of Smo. Here, we identify a novel E3 ligase of Smo, Herc4, which binds to Smo, and regulates Hh signalling by controlling Smo ubiquitination and degradation. Interestingly, ou

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31

Riobo, Natalia A., and David R. Manning. "Pathways of signal transduction employed by vertebrate Hedgehogs." Biochemical Journal 403, no. 3 (2007): 369–79. http://dx.doi.org/10.1042/bj20061723.

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Signalling by Hh (Hedgehog) proteins is among the most actively studied receptor-mediated phenomena relevant to development and post-embryonic homoeostatic events. The impact of signalling by the Hh proteins is profound, and work pertaining to the presentation of these proteins and the pathways engaged by them continues to yield unique insights into basic aspects of morphogenic signalling. We review here the mechanisms of signalling relevant to the actions of Hh proteins in vertebrates. We emphasize findings within the past several years on the recognition of, in particular, Sonic hedgehog by

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Yamashita, Erika, Shinichi Negishi, Jun Kikuta, Mami Shimizu, and Hidenobu Senpuku. "Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro." Dentistry Journal 12, no. 4 (2024): 108. http://dx.doi.org/10.3390/dj12040108.

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Improper mechanical stress may induce side effects during orthodontic treatment. If the roots and alveolar bones are extensively resorbed following excess mechanical stress, unplanned tooth mobility and inflammation can occur. Although multiple factors are believed to contribute to the development of side effects, the cause is still unknown. Sonic hedgehog (Shh), one of the hedgehog signals significantly associated with cell growth and cancer development, promotes osteoclast formation in the jawbone. Shh may be associated with root and bone resorptions during orthodontic treatment. In this stu

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Girgiri, I., B. Gambo, B. Ibrahim, and A. Bwala. "Morphometric studies of some visceral organs and gastrointestinal tract of four-toed african hedgehog (atelerix albiventris)." Journal of Morphological Sciences 32, no. 01 (2015): 029–32. http://dx.doi.org/10.4322/jms.071014.

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Abstract Introductions: Morphometric studies were carried out on some visceral organs and gastrointestinal tract of African four-toed hedgehogs found in Maiduguri, Nigeria. Materials and Methods: Twelve (12) healthy adult hedgehogs, (6 male and 6 females) were used. The overall mean body weight was 239.5±28.3 g, and was statistically not significant (p > 0.05) between the sexes. The absolute (g) and relative (%) values for nearly all the visceral organs measured were consistently higher in the female, but were statistically not significant (p > 0.05) between the sexes. Results: The gastr

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He, Xuelian, Liguo Zhang, Ying Chen та ін. "The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma". Nature Medicine 20, № 9 (2014): 1035–42. http://dx.doi.org/10.1038/nm.3666.

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Liu, Chuanliang, Qiongqiong Hu, Jia Jing, et al. "Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons." Molecular and Cellular Neuroscience 83 (September 2017): 65–73. http://dx.doi.org/10.1016/j.mcn.2017.06.005.

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Singh, Jaskirat, Xiaohui Wen, and Suzie J. Scales. "The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels." Journal of Biological Chemistry 290, no. 49 (2015): 29663–75. http://dx.doi.org/10.1074/jbc.m115.665810.

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Zhan, Jing, Liang-liang Shi, Yan Wang, Bai Wei, and Sheng-li Yang. "In Vivo Study on the Effects of Xiaoaiping on the Stemness of Hepatocellular Carcinoma Cells." Evidence-Based Complementary and Alternative Medicine 2019 (June 23, 2019): 1–10. http://dx.doi.org/10.1155/2019/4738243.

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Aims.The aim of this study was to examine the effects of Xiaoaiping on the stemness of hepatocellular carcinoma (HCC) cellsin vivoand to investigate the underlying molecular mechanism.Methods.A subcutaneous xenograft nude mouse model was established using Hep3B-derived HCC cells. The mice were randomly assigned to the 100 mg/kg Xiaoaiping or 100μL/20 g normal saline (control) groups (n =3/sex/group) for daily intragastric administration for 14 days. The tumor size was closely monitored during the dosing phase. After the treatment period, the tumor tissues were weighed and harvested for mRNA an

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Pfirrmann, Thorsten, Enrico Jandt, Swantje Ranft, et al. "Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development." Proceedings of the National Academy of Sciences 113, no. 36 (2016): 10103–8. http://dx.doi.org/10.1073/pnas.1600770113.

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Pax6 is a key transcription factor involved in eye, brain, and pancreas development. Although pax6 is expressed in the whole prospective retinal field, subsequently its expression becomes restricted to the optic cup by reciprocal transcriptional repression of pax6 and pax2. However, it remains unclear how Pax6 protein is removed from the eyestalk territory on time. Here, we report that Mid1, a member of the RBCC/TRIM E3 ligase family, which was first identified in patients with the X-chromosome–linked Opitz BBB/G (OS) syndrome, interacts with Pax6. We found that the forming eyestalk is a major

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Gonzalez-Quevedo, Rosa, Marina Shoffer, Lily Horng, and Anthony E. Oro. "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4." Journal of Cell Biology 168, no. 3 (2005): 453–63. http://dx.doi.org/10.1083/jcb.200409078.

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During development, dynamic remodeling of the actin cytoskeleton allows the precise placement and morphology of tissues. Morphogens such as Sonic hedgehog (Shh) and local cues such as receptor protein tyrosine phosphatases (RPTPs) mediate this process, but how they regulate the cytoskeleton is poorly understood. We previously identified Basal cell carcinoma–enriched gene 4 (BEG4)/Missing in Metastasis (MIM), a Shh-inducible, Wiskott-Aldrich homology 2 domain–containing protein that potentiates Gli transcription (Callahan, C.A., T. Ofstad, L. Horng, J.K. Wang, H.H. Zhen, P.A. Coulombe, and A.E.

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Mukhopadhyay, Saikat, Xiaohui Wen, Navneet Ratti, et al. "The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling." Cell 152, no. 1-2 (2013): 210–23. http://dx.doi.org/10.1016/j.cell.2012.12.026.

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Xie, Chen, Pen-Jen Lin, and Jijun Hao. "Eggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance." Biomedicines 9, no. 5 (2021): 538. http://dx.doi.org/10.3390/biomedicines9050538.

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Prostate cancer chemoresistance is a major therapeutic problem, and the underlying mechanism is not well understood and effective therapies to overcome this problem are not available. Phosphodiesterase-4 (PDE4), a main intracellular enzyme for cAMP hydrolysis, has been previously shown to involve in the early chemo-sensitive prostate cancer cell proliferation and progression, but its role in the more-advanced chemo-resistant prostate cancer is completely unknown. Here we found that the expression of PDE4 subtype, PDE4D, is highly elevated in the chemo-resistant prostate cancer cells (DU145-TxR

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Heller, Daniel A., Daniel Tylawsky, and G. Praveen Raju. "Abstract 1992: P-selectin-targeted delivery of intracranial therapeutics across an intact BBB in Sonic Hedgehog medulloblastoma." Cancer Research 83, no. 7_Supplement (2023): 1992. http://dx.doi.org/10.1158/1538-7445.am2023-1992.

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Abstract Medulloblastoma (MB) is the most common malignant pediatric brain tumor with ~30% mediated by Sonic hedgehog (SHH) signaling. While SHH effector Smoothened inhibition is promising, therapeutic index is reduced by high systemic doses required for sufficient intracranial drug concentrations. Treatment-related toxicities associated with radiation therapy result in lifelong morbidity, and SHH pathway inhibition in children notably results in permanent bone defects. Here, we found that nanoparticle-mediated P-selectin targeting on tumor vasculature induces caveolin-1-dependent transcellula

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Zakharova, Galina, Alexander Modestov, Polina Pugacheva, et al. "Distinct Traits of Structural and Regulatory Evolutional Conservation of Human Genes with Specific Focus on Major Cancer Molecular Pathways." Cells 12, no. 9 (2023): 1299. http://dx.doi.org/10.3390/cells12091299.

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The evolution of protein-coding genes has both structural and regulatory components. The first can be assessed by measuring the ratio of non-synonymous to synonymous nucleotide substitutions. The second component can be measured as the normalized proportion of transposable elements that are used as regulatory elements. For the first time, we characterized in parallel the regulatory and structural evolutionary profiles for 10,890 human genes and 2972 molecular pathways. We observed a ~0.1 correlation between the structural and regulatory metrics at the gene level, which appeared much higher (~0

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Shimada, Issei S., Sun-Hee Hwang, Bandarigoda N. Somatilaka, et al. "Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis." Cell Reports 22, no. 5 (2018): 1169–84. http://dx.doi.org/10.1016/j.celrep.2018.01.018.

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Amin, A., Y. Li, and R. Finkelstein. "Hedgehog activates the EGF receptor pathway during Drosophila head development." Development 126, no. 12 (1999): 2623–30. http://dx.doi.org/10.1242/dev.126.12.2623.

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The Hedgehog (Hh) and Epidermal growth factor receptor (EGFR) signaling pathways play critical roles in pattern formation and cell proliferation in invertebrates and vertebrates. In this study, we demonstrate a direct link between these two pathways in Drosophila melanogaster. Hh and EGFR signaling are each required for the formation of a specific region of the head of the adult fruitfly. We show that hh and vein (vn), which encodes a ligand of the Drosophila EGFR (Schnepp, B., Grumbling, G., Donaldson, T. and Simcox, A. (1996) Genes Dev. 10, 2302–13), are expressed in adjacent domains within

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Shyamala, Baragur V., and Krishna Moorthi Bhat. "A positive role for Patched-Smoothened signaling in promoting cell proliferation during normal head development in Drosophila." Development 129, no. 8 (2002): 1839–47. http://dx.doi.org/10.1242/dev.129.8.1839.

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The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G-protein-coupled receptor; binding of Hedgehog ligand to Patched relieves this negative interaction and allows signaling by Smoothened. We show that Ptc regulates Drosophila head development by promoting cell proliferation in the eye-antennal disc. During head morphogenesis, Patched positively interacts with Smoothened, which leads to the activati

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Doheny, Daniel, Sara G. Manore, Grace L. Wong, and Hui-Wen Lo. "Hedgehog Signaling and Truncated GLI1 in Cancer." Cells 9, no. 9 (2020): 2114. http://dx.doi.org/10.3390/cells9092114.

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The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a consequence of improper control, aberrant HH signaling results in tumorigenesis and supports aggressive phenotypes of human cancers, such as neoplastic transformation, tumor progression, metastasis, and drug resistance. Canonical activation of HH signaling occurs through binding of HH ligands to the transmembrane receptor Patched 1 (PTCH1), which derepresses the transmembrane G protein-coupled receptor Smoothened (SMO). Consequently, the glioma-associated oncogene homolog 1 (GLI1) zinc-finger transcripti

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Li, Fenghe, Molly Duman-Scheel, Dong Yang, et al. "Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G 1 Cyclin-Retinoblastoma Axis." Arteriosclerosis, Thrombosis, and Vascular Biology 30, no. 9 (2010): 1787–94. http://dx.doi.org/10.1161/atvbaha.110.208520.

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Hammerschmidt, Matthias, and Andrew P. McMahon. "The Effect of Pertussis Toxin on Zebrafish Development: A Possible Role for Inhibitory G-Proteins in Hedgehog Signaling." Developmental Biology 194, no. 2 (1998): 166–71. http://dx.doi.org/10.1006/dbio.1997.8796.

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Arveseth, Corvin D., John T. Happ, Danielle S. Hedeen, et al. "Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits." PLOS Biology 19, no. 4 (2021): e3001191. http://dx.doi.org/10.1371/journal.pbio.3001191.

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The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription factors via an unknown mechanism. Here, we show that, rather than conforming to traditional GPCR signaling paradigms, SMO activates GLI by binding and sequestering protein kinase A (PKA) catalytic subunits at the membrane. This sequestration, triggered by GPCR kinase (GRK)-mediated phosphorylation of SMO

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