Academic literature on the topic 'G protein-coupled receptor'

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Journal articles on the topic "G protein-coupled receptor"

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Tibrewal, Richa, Reynoldly Kharsyntiew, Farida Dawood, and Archana Sharma. "A REVIEW ON G-PROTEIN COUPLED RECEPTOR." International Journal of Current Pharmaceutical Review and Research 13, no. 04 (2021): 01–09. https://doi.org/10.5281/zenodo.12664417.

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AbstractG protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domainreceptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linkedreceptors (GPLR), constitute a large protein family of receptors that detect molecules outsidethe cell and activate internal signal transduction pathways and, ultimately, cellular responses.Coupling with G proteins, they are called seven-transmembrane receptors because they passthrough the cell membrane seven times. G protein–coupled receptors are found only ineukaryotes, including yeast, choanof
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Sulon, Sarah M., and Jeffrey L. Benovic. "Targeting G protein–coupled receptor kinases to G protein–coupled receptors." Current Opinion in Endocrine and Metabolic Research 16 (February 2021): 56–65. http://dx.doi.org/10.1016/j.coemr.2020.09.002.

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Zeng, Fu-Yue. "Signaling by G Protein-Coupled Receptors." Electronic Journal of Pathology and Histology 6, no. 1 (2000): 13. https://doi.org/10.3233/eph-2000-6_1_13.

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G protein-coupled receptors represent one of the largest families of cell surface receptors in nature. These receptors play fundamental roles in diverse physiological processes such as neurotransmission, cellular metabolism, cell differentiation and growth as well as immune response. In response to extracellular ligands, G protein-coupled receptors specifically interact with heterotrimeric G proteins that can then activate or inhibit effector enzymes, ultimately leading to the physiological response. Biochemical and mutational studies have revealed the molecular mechanisms of ligand-receptor i
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Hille, Bertil. "G protein-coupled receptor." Scholarpedia 4, no. 12 (2009): 8214. http://dx.doi.org/10.4249/scholarpedia.8214.

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Milligan, G. "Oligomerisation of G-protein-coupled receptors." Journal of Cell Science 114, no. 7 (2001): 1265–71. http://dx.doi.org/10.1242/jcs.114.7.1265.

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A range of approaches have recently provided evidence that G-protein-coupled receptors can exist as oligomeric complexes. Both homo-oligomers, comprising multiple copies of the same gene product, and hetero-oligomers containing more than one receptor have been detected. In several, but not all, examples, the extent of oligomerisation is regulated by the presence of agonist ligands, and emerging evidence indicates that receptor hetero-oligomers can display distinct pharmacological characteristics. A chaperonin-like role for receptor oligomerisation in effective delivery of newly synthesised rec
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Gomes, Ivone, Mohammed Akli Ayoub, Wakako Fujita, Werner C. Jaeger, Kevin D. G. Pfleger, and Lakshmi A. Devi. "G Protein–Coupled Receptor Heteromers." Annual Review of Pharmacology and Toxicology 56, no. 1 (2016): 403–25. http://dx.doi.org/10.1146/annurev-pharmtox-011613-135952.

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A.C., Hanyaloglu, Kroeger K.M., and Eidne K.A. "G-Protein Coupled Receptor Oligomerization." Pharmaceutical News 9, no. 5 (2002): 317–25. http://dx.doi.org/10.1080/10718940216626.

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Pitcher, Julie A., Neil J. Freedman, and Robert J. Lefkowitz. "G PROTEIN–COUPLED RECEPTOR KINASES." Annual Review of Biochemistry 67, no. 1 (1998): 653–92. http://dx.doi.org/10.1146/annurev.biochem.67.1.653.

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Palczewski, Krzysztof. "G Protein–Coupled Receptor Rhodopsin." Annual Review of Biochemistry 75, no. 1 (2006): 743–67. http://dx.doi.org/10.1146/annurev.biochem.75.103004.142743.

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Lohse, Martin J., Cornelius Krasel, Rainer Winstel, and Federico Mayor. "G-protein-coupled receptor kinases." Kidney International 49, no. 4 (1996): 1047–52. http://dx.doi.org/10.1038/ki.1996.153.

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Dissertations / Theses on the topic "G protein-coupled receptor"

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Kidley, N. J. "Modelling G protein-coupled receptor activation." Thesis, University of Essex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402792.

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Gros, Robert. "Regulation of G-protein-coupled receptor function, a role for increased G-protein-coupled receptor kinase-2 protein content." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/NQ58133.pdf.

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Zazzu, Valeria. "The human G protein-coupled receptor GPR30." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16325.

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Im 1997 wurden der Orphan GPR30 aus HUVECs kloniert, die FSS ausgesetzt waren. In dieser Studie konnte gezeigt werden dass die Expression von GPR30 durch die FSS-Behandlung im Vergleich zu unbehandelten HUVEC-Zellen deutlich induziert wurde. Daraufhin wurde in einer Studie von Isensse et al. die zelluläre und gewebsspezifische Expression von GPR30 in GPR30-LacZ Reportergen-Mäusen untersucht. Es konnte eine Expression von GPR30 vorwiegend in den Endothelzellen der kleinen Arterien verschiedenster Gewebetypen nachgewiesen werden. GPR30 war postuliert dass E2 direkt binden kann und dadurch rasche
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Higgs, C. "A computational study of the G-protein-G-protein coupled receptor interaction." Thesis, University of Essex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324216.

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Simpson, Lisa Marie. "Computational studies of G protein-coupled receptor activation." Thesis, University of Essex, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520117.

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Felce, James H. "A survey of G protein-coupled receptor stoichiometry." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ae078d13-fef7-4f1f-a8ea-c2e5412f59ff.

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G-protein coupled receptors (GPCRs) represent the largest family of transmembrane proteins in the human genome. Their biological and medical significance has driven extensive research into their structure and function, yet a number of important aspects of their behaviour remain unresolved. Arguably the most contentious debate in the field concerns whether or not the receptors form stable homo- and hetero-oligomeric interactions, and there is currently no consensus on the extent or purpose of GPCR oligomerisation. In this thesis, the ‘typical’ stoichiometry of Rhodopsin family GPCRs is investig
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Sallander, Eva Jessica. "The mechanism of G protein coupled receptor activation: the serotonin receptors." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/77901.

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Una de las principales cuestiones en farmacología molecular de los GPCR es entender los mecanismos estructurales de las siete hélices transmembrana (TM) que se producen para estabilizar ya sea Rg o los diferentes estados R*. Para entender el mecanismo que cambia el equilibrio del conjunto a un estado activo R* se construyeron tres de los receptores de la serotonina (5-HT4, 5-HT6, y 5 HT7) sobre la base de su información más reciente de cristalografía de rayos X. Dando lugar a dos modelos de cada receptor: una inactiva y otra activa. Los modelos, mejorados y evaluados con la ayuda de datos fa
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Fransen, Maikel Peter. "Stabilizing the G protein-coupled receptor rhodopsin/heterotrimeric G protein transducin signalling complex." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610816.

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Sheng, Yinglun. "G protein signaling and G protein coupled receptor (GPCR) pathway in Xenopus oocyte maturation." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/29262.

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Xenopus laevis oocytes are physiologically arrested at the first meiotic prophase. Progesterone reinitiates meiosis (maturation) through inhibition of an oocyte adenylyl cyclase (AC) and reduction of intracellular cAMP. However, the mechanism by which progesterone regulates AC activity and cAMP level still remains unclear. In this thesis, I summarize work I conducted that collectively helps elucidate how high levels of cAMP might be achieved in G2 arrested oocytes. In Chapter 2, I describe our finding that inhibiting endogenous G-protein betagamma subunits, through the use of two structurally
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Hollmann, Markus W. "Local anesthetic interactions with G protein-coupled receptor signaling." Aachen : Maastricht : Shaker ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=7012.

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Books on the topic "G protein-coupled receptor"

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R, George Susan, and O'Dowd Brian Francis 1950-, eds. G protein-coupled receptor-protein interactions. Wiley-Liss, 2005.

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Herrick-Davis, Katharine, Graeme Milligan, and Giuseppe Di Giovanni, eds. G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8.

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Stevens, Craig W., ed. G Protein-Coupled Receptor Genetics. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-779-2.

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Gurevich, Vsevolod V., Eugenia V. Gurevich, and John J. G. Tesmer, eds. G Protein-Coupled Receptor Kinases. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3798-1.

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Tiberi, Mario, ed. G Protein-Coupled Receptor Signaling. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9121-1.

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Martins, Sofia Aires M., and Duarte Miguel F. Prazeres, eds. G Protein-Coupled Receptor Screening Assays. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1221-7.

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Prazeres, Duarte Miguel F., and Sofia Aires M. Martins, eds. G Protein-Coupled Receptor Screening Assays. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2336-6.

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Running, Mark P., ed. G Protein-Coupled Receptor Signaling in Plants. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-532-3.

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Neve, Kim A., ed. Functional Selectivity of G Protein-Coupled Receptor Ligands. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-335-0.

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Prazeres, Duarte Miguel F., and Sofia Aires M. Martins. G protein-coupled receptor screening assays: Methods and protocols. Humana Press, 2015.

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Book chapters on the topic "G protein-coupled receptor"

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Iismaa, Tiina P., Trevor J. Biden, and John Shine. "Cell Surface Receptors and the G Protein-Coupled Receptor Superfamily." In G Protein-Coupled Receptors. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-21930-0_1.

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Colao, Annamaria, and Claudia Pivonello. "G-Protein-Coupled Receptor." In Encyclopedia of Pathology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-28845-1_5112-1.

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Colao, Annamaria, and Claudia Pivonello. "G-Protein-Coupled Receptor." In Endocrine Pathology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62345-6_5112.

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Iismaa, Tiina P., Trevor J. Biden, and John Shine. "Structural Determinants of Receptor Function." In G Protein-Coupled Receptors. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-21930-0_3.

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Rossi, Mario, Roberto Maggio, Irene Fasciani, and Marco Scarselli. "Historical Perspectives: From Monomers to Dimers and Beyond, an Exciting Journey in the World of G Protein-Coupled Receptors." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_1.

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Harikumar, Kaleeckal G., and Laurence J. Miller. "Secretin Receptor Dimerization. Prototypic of Class B GPCR Behavior." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_10.

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Gingell, Joseph J., Christopher S. Walker, and Debbie L. Hay. "Class B GPCR: Receptors and RAMPs." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_11.

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Fan, Qing R., William Y. Guo, Yong Geng, and Marisa G. Evelyn. "Class C GPCR: Obligatory Heterodimerization of GABAB Receptor." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_12.

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Hlaváčková, Veronika, Laurent Prézeau, Jean-Philippe Pin, and Jaroslav Blahos. "Class C GPCRs: Metabotropic Glutamate Receptors." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_13.

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Gibert, Arthur, Martin Lehmann, Burkhard Wiesner, and Ralf Schülein. "The Monomer/Homodimer Equilibrium of G Protein-Coupled Receptors: Formation in the Secretory Pathway and Potential Functional Significance." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_14.

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Conference papers on the topic "G protein-coupled receptor"

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Fang, Ye, Anthony G. Frutos, and Joydeep Lahiri. "G protein-coupled receptor (GPCR) microarrays." In International Symposium on Biomedical Optics, edited by Darryl J. Bornhop, David A. Dunn, Raymond P. Mariella, Jr., et al. SPIE, 2002. http://dx.doi.org/10.1117/12.472073.

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Arora, Bhumika. "Refinement of G protein-coupled receptor structure models." In BCB '20: 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. ACM, 2020. http://dx.doi.org/10.1145/3388440.3414920.

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Komolov, Konstantin, Daniela K. Laurinavichyute, Anshul Bhardwaj, and Jeffrey L. Benovic. "Calcium-dependent regulation of G protein-coupled receptor kinases." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.242570.

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Moritz, Amy E., Nora S. Madaras, Kirsten K. Snyder, et al. "Regulation of Dopamine Receptor Subtypes by G Protein-Coupled Receptor Kinase Isoforms." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.159.988010.

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Kertkeidkachorn, Natthawut, Lihua Zhao, Xin Liu, and Ryutaro Ichise. "Knowledge Representation of G-Protein-Coupled Receptor Signal Transduction Pathways." In 2019 IEEE 13th International Conference on Semantic Computing (ICSC). IEEE, 2019. http://dx.doi.org/10.1109/icosc.2019.8665519.

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Fayyaz, Mudassir, Adnan Mujahid, Asifullah Khan, Tae-Sun Choi, and Nadeem Iqbal. "G-protein Coupled Receptor Subfamilies Prediction Based on Nearest Neighbor Approach." In 2007 IEEE 7th International Symposium on BioInformatics and BioEngineering. IEEE, 2007. http://dx.doi.org/10.1109/bibe.2007.4375745.

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Wang, Di. "G-protein-coupled receptor controls steroid hormone signaling in cell membrane." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.107278.

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Meng, Ran, Ying Xiong, Yuan Zhao, et al. "Abstract 1149: Interaction with NHERF1 enhances protein stability of G protein-coupled estrogen receptor." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1149.

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Gu, Quan, Yong-Sheng Ding, and Tong-Liang Zhang. "Prediction of G-Protein-Coupled Receptor Classes with Pseudo Amino Acid Composition." In 2008 2nd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2008. http://dx.doi.org/10.1109/icbbe.2008.215.

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Bhat, Raksha, Puja Yadav, Pavel Christiny, Rachel Schiff, and Meghana V. Trivedi. "Abstract 3573: Novel G protein-coupled receptor targets in HER2+ breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3573.

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Reports on the topic "G protein-coupled receptor"

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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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Liu, Mingyao. Role of a Novel Prostate-Specific G-Protein Coupled Receptor (PSGR) in Prostate Tumor Development. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada415521.

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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction w
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Ye, Libin, Christopher Andrew Neale, Adnan Sljoka, et al. Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1434450.

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Neale, Christopher Andrew, and Angel Enrique Garcia. Regulation of Intercellular Signaling by G protein-coupled receptors. Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1496726.

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