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Dissertations / Theses on the topic 'G proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 April 2025

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1

Pateman, Cassandra Sophie Catherine. "RGS proteins and G protein signalling." Thesis, University of Warwick, 2002. http://wrap.warwick.ac.uk/2367/.

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The work within this thesis is concerned with the creation of a temperature-sensitive Schizosaccharomyces pombe marker protein, and the regulation of the pheromone communication system of Sz. pombe reporter strains by RGS proteins. There are a limited number of marker proteins available for use in the genetic manipulation of Sz. pombe, and the generation of a temperature-sensitive Ura4p was envisaged to expand the scope of carrying out sequential gene disruptions in the fission yeast. PCR-based mutagenesis was used to introduce mutations in the ura4 cassette, and a leucine to proline mutation

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2

Nauli, Sehat. "Folding kinetics and redesign of Peptostreptococcal protein L and G /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/9237.

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3

Nguyen, Giang Huong. "A functional analysis of the human LPA₁G protein coupled receptor." Thesis, Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131304/unrestricted/nguyen%5Fgiang%5Fh%5F200405%5Fms.pdf.

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4

Ghimire, Ganga D., ガンガＤ. ギミレ, Kenichiro Imai, 賢一郎今井, Fumitsugu Akazawa, 史嗣赤沢, Toshiyuki Tsuji, et al. "Physicochemical properties of amino acid sequences of G-proteins for understanding GPCR-G-protein coupling." Chem-Bio Informatics Society, 2006. http://hdl.handle.net/2237/9277.

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5

Drinnan, Suzane Loraine. "G proteins in the basal ganglia." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28981.

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G proteins are alpha-beta-gamma heterotrimers in the resting state, bound to GDP and complexed with the unbound receptor. Once the receptor becomes occupied, the alpha subunit exchanges GDP for GTP, becomes activated, and dissociates from the receptor and can stimulate or inhibit many intracellular activities such as phosphorylation and channel conductance. For example, Gs and Golf alpha subunits stimulate and Gi alpha subunits inhibit adenylyl cyclase. Go alpha subunits are abundant in brain, but are of unknown function. cDNAs for the alpha subunit have been cloned. In order to examine the r

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6

Hodson, Elizabeth Anne Marie. "G protein regulation of phospholipase C in vascular smooth muscle." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390487.

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7

Song, Hongman. "The roles of the phosducin family proteins in the regulation of heterotrimeric G proteins in vertebrate photoreceptors." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10413.

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Thesis (Ph. D.)--West Virginia University, 2009.<br>Title from document title page. Document formatted into pages; contains vi, 96 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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8

Brownlie, Zoe. "Regulation of signal transduction by RGS4." Connect to e-thesis, 2007. http://theses.gla.ac.uk/124/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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9

Adhikari, Anirban. "Regulation of guanine nucelotide exchange in inhibitory G protein alpha subunit by activator of G protein signaling 3 and novel regulatory peptides." Embargoed access until after 12/19/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=114.

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10

Han, Li. "G protein coupled receptor signaling to phospholipase D1 mediated by G12 type G proteins, LIM kinase and cofilin." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968929923.

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11

Clyde-Smith, Jodi. "Characterization of ras isoform activation by ras guanine nucleotide exchange factors /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16393.pdf.

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12

Tsie, Marlene S. "Cloning and Immunolocalization of G Proteins in the Spionid Polychaete Dipolydora quadrilobata." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/TsieMS2006.pdf.

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13

Yang, Zhao 1970. "Identification of a novel anti-apoptotic protein and characterization of mammalian regulators of G protein signaling (RGSs) in yeast." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111875.

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Regulators of G protein signaling (RGSs) are negative regulators of G protein coupled receptors (GPCRs). Our lab has demonstrated that yeast Saccharomyces cerevisiae is a useful system to study RGS and G protein signaling. Mammalian RGSs can be expressed in yeast and favored to interact with mammalian GPCRs as well.<br>Based on the observation that human RGS1 causes yeast cell growth arrest, I therefore used RGS1 expressing yeast cells to screen a mouse T cell cDNA library in order to find potential interacting proteins. From the screen, I identified a mouse sphingomyelin synthase 1 (SMS1) cDN

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14

Lo, Kin Ho. "Activation of signal transducer and activator of transcription 3 (STAT3) by G[alpha]16 and G[alpha]14 via a c-Src/JAK-and ERK-dependent mechanism /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20LO.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 92-111). Also available in electronic version. Access restricted to campus users.

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15

Hill, Claire Louise. "The use of Schizosaccharomyces pombe to investigate reguator of G protein signalling proteins." Thesis, University of Warwick, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487827.

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16

Barclay, Elaine. "Characterisation of palmitoylation in alpha₂_A adrenoceptor and 5-HT₁_A serotonin receptor-G₀₁α G protein fusion proteins". Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/4998/.

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Palmitoylation variant GPCR-G protein fusion proteins were created between the porcine u2A-adrenoceptor or the human 5-HT1A-serotonin receptor and the pertussis toxin resistant, Cys35lIle, form of the rat Go1u protein. These palmitoylation-variant fusions were transiently expressed in HEK293T cells prior to analysis of the regulation of palmitoylation and the functional consequences of palmitoylation for both the GPCR and G protein parts of the fusions. When the regulation of palmitoylation was studied for u2A-adrenoceptor-GoluCys35IIle fusion proteins, dynamic palmitoylation and depalmitoylat

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17

Slessareva, Janna Eugenievna. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2907.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 200 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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18

Ma, Hongzheng. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2978.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains viii, 264 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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19

Armenta, Blanco Jenny Marcela. "Capillary Electrophoresis of Proteins with Selective On-line Affinity Monoliths." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1594.pdf.

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20

Runne, Caitlin M. "Function and Activation Mechanism of PLEKHG2, A Novel G Beta Gamma-Activated RhoGEF in Leukemia Cells." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4907.

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The Rho family of GTPases plays a crucial role in the regulation of diverse cellular processes, including proliferation and actin cytoskeletal rearrangement to promote cell migration. However, dysregulation of RhoGTPases has been associated with disease, particularly cancers such as leukemia. Despite this, RhoGTPases are rarely mutated in cancer. Rather, dysregulation of their regulatory proteins through mutation or overexpression contributes to disease pathogenesis. RhoGTPases are activated through Rho guanine nucleotide exchange factors (GEFs). Although over eighty RhoGEFs have been identifi

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21

Marcotte, Eric R. "G proteins and Parkinson's disease, the role of signal transducing G proteins in mediating dopamine receptor supersensitivity in Parkinson's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0012/NQ42863.pdf.

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22

Zheng, Bin. "RGS proteins : bridging the "GAP"s between G protein signaling and membrane trafficking /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3059905.

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23

Terasmaa, Anton. "Dopamine D2 receptor G protein coupling and its regulation /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-788-6/.

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24

Anderson, David John. "Heterotrimeric G proteins in plant signal transduction : characterisation of tobacco and arabidopsis G ̊subunits /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16840.pdf.

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25

Legate, Kyle R. Andrews D. W. "Characterization of the beta-subunit of the mammalian SRP receptor and its role in assembly of the SRP receptor /." *McMaster only, 2003.

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26

Vasara, Tuija. "Functional analysis of the RHOIII and 14-3-3 proteins of Trichoderma reesei /." Espoo [Finland] : Technical Research Centre of Finland, 2002. http://www.vtt.fi/inf/pdf/publications/2002/P466.pdf.

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27

Ip, Koon-ching. "Role of G[alpha]-interacting protein (GAIP) in modulation of MAPK pathways /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20IP.

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28

Poon, Lydia See Wing. "Molecular basis of G[beta][gamma] signaling : dimer formation and interaction with effectors and G[alpha] subunits /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BICH%202009%20POON.

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29

Bane, Steven Edward. "Expression and characterization of the human neurokinin 1 receptor from Escherichia coli." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 99 p, 2007. http://proquest.umi.com/pqdweb?did=1342742951&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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30

Krishnan, Kadalmani. "Characterisation of the G protein controlled tyrosine kinase, ACK1 and its interaction with nucleolar partner proteins." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610698.

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31

Mitchell, Christopher J. "The regulation of polyphosphoinositide synthesis in rat liver." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389879.

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32

Srivastava, Deepak Prakash. "Characterisation of a novel Drosophila G-protein coupled receptor differentially activated by catecholamines and steroids." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614677.

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33

Damoulakis, George. "The role of RhoG in neutrophil biology." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610225.

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34

Ferreira, Cláudia Susana da Rosa. "Organelle-specific roles for the Arf-like G proteins Arl5 and Arl8." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609430.

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35

Chan, Pui Wai. "Fhit : a novel interacting partner of G[alpha][subscript q] proteins /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20CHAN.

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36

Humphrey, Tania Vivienne. "Characterisation of a putative G-protein coupled receptor and its protein interacting partner in Arabidopsis /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16260.pdf.

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37

Bailey, Laura Kate. "Structural and biochemical studies of small G protein effectors." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608914.

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38

McLeman, Elizabeth Rae. "Brain G-proteins in drug dependence, a postmortem study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/MQ45410.pdf.

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39

Lupi, Rosita. "Characterization of post translational modification of heterotrimeric G proteins." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343748.

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40

Stanley, R. J. "Mathematical models of signalling through G proteins and phospholipids." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1472846/.

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G proteins and phospholipids are two major classes of signalling molecule. ey are each-independently and together-involved in diverse 'signalling pathways' - bio- chemical networks through which cells maintain healthy responses to stimuli. A unique 'cross-talk motif' is formed by regulation of the phospholipid-modifying enzymes phospholipase D (PLD) and phosphatidylinositol 4-phosphate 5-kinase (PI4P5K) by the Arf family of small G proteins and-curiously-each other's product. Here, understanding of this inherently complex motif has been strengthened by the development and analysis of mathemati

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41

Coleman, Struan Howard. "The regulation of the rpmB,G operon of Escherichia coli." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260156.

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42

Moon, Hyo-Eun. "Differential G protein activation by fusion proteins between the human #delta#-opioid receptor and Gâ†iâ‚Î±/Gâ†oâ‚Î± proteins." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366183.

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43

Murphy, Jonathan Paul. "The cloning, expression, and characterisation of Streptoccal protein G." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316402.

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44

Wu, Hoi Ti. "Regulation of the pro-survival AKT signaling cascade : roles of receptor tyrosine kinases, G proteins, and their crosstalks /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20WU.

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45

Lai, Chun Wan Jeffrey. "Mechanism of G Protein Beta-Gamma Assembly Mediated by Phosducin-Like Protein 1." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/3190.

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G-protein coupled receptor signaling (GPCR) is essential for regulating a large variety of hormonal, sensory and neuronal processes in eukaryotic cells. Because the regulation of these physiological responses is critical, GPCR signaling pathways are carefully controlled at different levels within the cascade. Phosducin-like protein 1 (PhLP1) can bind the G protein βγ dimer and participate in GPCR signaling. Recent evidence has supported the concept that PhLP1 can serve as a co-chaperone of the eukaryotic cytosolic chaperonin complex CCT/TRiC to mediate G βγ assembly. Although a general mechani

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46

Venkatakrishnan, Aiveliagaram Jayagopal. "Understanding the principles of structural organisation of G-protein-coupled receptors." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648272.

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47

García-Jiménez, Angela. "G-proteins and adenylyl cyclase in Alzheimer's disease postmortem brain /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-103-9.

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48

Onel, Buket, and Buket Onel. "Promoter G-quadruplexes and their Interactions with Ligands and Proteins." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621857.

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G-quadruplex secondary structures are four-stranded globular nucleic acid structures that form in specific DNA and RNA G-rich sequences with biological significance, such as those found in human telomeres, oncogene promoter regions, replication initiation sites, and 5’- and 3’-untranslated (UTR) regions, which have been identified as novel drug targets. The non-canonical G-quadruplex secondary structures readily form under physiologically relevant ionic conditions, and exhibit great diversity in their topologies and loop conformations depending on the DNA or RNA sequences at hand. The structur

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49

Woon, Chee-Wai. "Mutations of the Alpha-Subunit of G-Proteins: A Thesis." eScholarship@UMMS, 1988. http://escholarship.umassmed.edu/gsbs_diss/296.

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Signal transduction by G-proteins (a heterotrimer membrane protein composed of an α, β, and γ subunit) requires that the α-subunit undergoes a transition from a GDP-bound inactive state to an activated GTP-bound state. The exchange of GDP for GTP leads to a conformational change in the α-subunit that results in the loss of affinity for the βγ subunits. We predicted that appropriate genetic manipulation of key regions of the α-subunit could result in the induction of the active conformation that would mimic at least in part the activated GTP-bound state. We have demonstrated that the substitu

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50

Casteel, Darren E. "Identification and characterization of G-Kinase I[beta] interacting proteins /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3099538.

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