Relevant bibliographies by topics / G6fL

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  2. Dissertations / Theses

Academic literature on the topic 'G6fL'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "G6fL"

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de VET, Edwin C. J. M., Begoña AGUADO, and R. Duncan CAMPBELL. "Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC." Biochemical Journal 375, no. 1 (October 1, 2003): 207–13. http://dx.doi.org/10.1042/bj20030293.

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The human G6f protein, which is encoded by a gene in the MHC, is a putative cell-surface receptor belonging to the immunoglobulin superfamily. The intracellular tail of G6f is 40 amino acids in length and contains one tyrosine residue (Y281), which is phosphorylated after treatment of cells with pervanadate. This tyrosine residue is found in a consensus-binding motif (YXN) for the Src homology 2 domains of Grb2 and Grb7 (where Grb stands for growth-factor-receptor-bound protein). Glutathione S-transferase pull-down assays showed that the interaction of G6f with both Grb2 and Grb7 is mediated through the Src homology 2 domains of these two proteins and is dependent on the phosphorylation of G6f. Immunoprecipitation experiments showed the interaction of full-length phosphorylated G6f with both full-length Grb2 and Grb7. Antibody cross-linking of G6f expressed in K562 cells resulted in a transient phosphorylation of p42/44 MAP kinase (also known as extracellular-signal-regulated protein kinase-1/2; MAP stands for mitogen-activated protein) which could be prevented by MAP kinase kinase (MEK) inhibitors. These results suggest a coupling of G6f with downstream signal transduction pathways involving Grb2 and Grb7, including the Ras–MAP kinase pathway.
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Macaulay, Iain C., Marloes R. Tijssen, Daphne C. Thijssen-Timmer, Arief Gusnanto, Michael Steward, Philippa Burns, Cordelia F. Langford, et al. "Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins." Blood 109, no. 8 (December 27, 2006): 3260–69. http://dx.doi.org/10.1182/blood-2006-07-036269.

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AbstractTo identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared using cDNA microarrays. Bioinformatical analysis of MK–up-regulated genes identified 151 transcripts encoding transmembrane domain-containing proteins. Although many of these were known platelet genes, a number of previously unidentified or poorly characterized transcripts were also detected. Many of these transcripts, including G6b, G6f, LRRC32, LAT2, and the G protein–coupled receptor SUCNR1, encode proteins with structural features or functions that suggest they may be involved in the modulation of platelet function. Immunoblotting on platelets confirmed the presence of the encoded proteins, and flow cytometric analysis confirmed the expression of G6b, G6f, and LRRC32 on the surface of platelets. Through comparative analysis of expression in platelets and other blood cells we demonstrated that G6b, G6f, and LRRC32 are restricted to the platelet lineage, whereas LAT2 and SUCNR1 were also detected in other blood cells. The identification of the succinate receptor SUCNR1 in platelets is of particular interest, because physiologically relevant concentrations of succinate were shown to potentiate the effect of low doses of a variety of platelet agonists.
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Hughes, Craig E., Uvaraj P. Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M. Dijkstra, Pudur Jagadeeswaran, and Stephen P. Watson. "G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes." PLoS ONE 7, no. 12 (December 21, 2012): e52622. http://dx.doi.org/10.1371/journal.pone.0052622.

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4

COZZOLINO, SALVATORE, PAOLO CAPUTO, SERENA ACETO, ALEX WIDMER, and AMOTS DAFNI. "Speciation processes in Eastern Mediterranean Orchis s.l. species: Molecular evidence and the role of pollination biology." Israel Journal of Plant Sciences 49, no. 2 (January 1, 2001): 91–103. http://dx.doi.org/10.1560/qv6m-e7a0-qfc7-g6bl.

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Dahab, Mohamed F. "Treatment Alternatives for Nitrate Contaminated Groundwater Supplies." Journal of Environmental Systems 17, no. 1 (January 1, 1987): 65–75. http://dx.doi.org/10.2190/h1yg-g6f3-892m-9n2p.

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Juarez, Patricia, Scott T. Walters, Mikyta Daugherty, and Christopher Radi. "A Randomized Trial of Motivational Interviewing and Feedback with Heavy Drinking College Students." Journal of Drug Education 36, no. 3 (September 2006): 233–46. http://dx.doi.org/10.2190/753n-8242-727t-g63l.

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7

Yamanaka, Takashi, Ken Akashi, and Masayuki Ishii. "Stroke Rehabilitation and Long Leg Brace." Topics in Stroke Rehabilitation 11, no. 3 (July 2004): 6–8. http://dx.doi.org/10.1310/g8rf-312l-g6fw-a8jw.

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8

Akiyama, M. Michael, Hiroko Akiyama, and Carolyn C. Goodrich. "Spatial Development across the Life Span." International Journal of Aging and Human Development 21, no. 3 (October 1986): 175–85. http://dx.doi.org/10.2190/00xv-bvmx-g6fn-0lnn.

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Fifth graders, ninth graders, college students, and persons over age sixty-five were given three pencil-and-paper tasks in spatial development. Knowledge of Euclidean space was assessed in each of these three tasks. In Task 1, the participants were asked to draw water lines in tilted bottles on a horizontal stand. In Task 2, they were asked to draw water lines in tilted bottles on a tilted stand. In Task 3, they were asked to give directions from one place to another on a hypothetical map. The performance on Task 1 and 2 increased from fifth grade to college. The performance of the elderly was the same as the college students on Task 1, and less than the college students in Task 2. The elderly participants' performance on Task 3 was better than the other three age groups. These results were discussed in terms of ecological validity, experience, and the number of competing cues to be processed simultaneously. Piaget's formulation on adult cognitive development was used to explain the elderly's performance in relation to other groups [1].
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Badve, Sunil, and Edward R. Burns. "D-Dimer Measurements Unhelpful for Ruling In DIC." Laboratory Medicine 31, no. 7 (July 2000): 383–86. http://dx.doi.org/10.1309/5lcf-21kn-vvv0-g6ll.

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Fonseca, Vera Regina J. R. M., and Vera Silvia R. Bussab. "Self, other and dialogical space in autistic disorders." International Journal of Psychoanalysis 87, no. 2 (April 2006): 439–55. http://dx.doi.org/10.1516/6cn4-9c1h-g6pl-hmpk.

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Dissertations / Theses on the topic "G6fL"

1

Pulipakkam, Radhakrishnan Uvaraj. "Studies on Zebrafish Thrombocyte Function." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984278/.

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Thrombocytes are important players in hemostasis. There is still much to be explored regarding the molecular basis of the thrombocyte function. In our previous microarray analysis data, we found IFT122 (an intraflagellar transport protein known to be involved in cilia formation) transcripts in zebrafish thrombocytes. Given recent discoveries of non-ciliary roles for IFTs, we examined the possibility that IFT122 affects thrombocyte function. We studied the role of IFT122 in thrombocyte function. We also found that IFT122 plays a central role in thrombocyte activation initiated by the agonists ADP, collagen, PAR-1 peptide and epinephrine. Although the receptors for ADP, PAR-1 peptide and epinephrine are present in the zebrafish genome, the collagen receptor GPVI was missing. In this study, we identified G6fL as a collagen receptor in zebrafish thrombocytes. Furthermore, IFT knockdown results in reduction in Wnt signaling. The Wnt signaling has been shown to be involved in megakaryocyte proliferation and proplatelets production. Therefore, defects in IFT could lead to thrombocytopenia. Splenectomy is performed in humans to treat such conditions. Therefore, in this study we developed a survival surgery protocol for splenectomy. We have shown that number of thrombocytes and their microparticles increase following splenectomy in zebrafish. Thus overall the studies on thrombocyte function in zebrafish could enhance fundamental knowledge on hemostasis and may provide future target candidates for therapies.
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2

Newland, Stephen Alexander. "Functional characterisation of LY6G6C, LY6G6D, G6B and G6F, cell surface receptors encoded by genes within the Human Major Histocompatibility Complex." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613107.

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