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Journal articles on the topic 'G6fL'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

de VET, Edwin C. J. M., Begoña AGUADO, and R. Duncan CAMPBELL. "Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC." Biochemical Journal 375, no. 1 (October 1, 2003): 207–13. http://dx.doi.org/10.1042/bj20030293.

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The human G6f protein, which is encoded by a gene in the MHC, is a putative cell-surface receptor belonging to the immunoglobulin superfamily. The intracellular tail of G6f is 40 amino acids in length and contains one tyrosine residue (Y281), which is phosphorylated after treatment of cells with pervanadate. This tyrosine residue is found in a consensus-binding motif (YXN) for the Src homology 2 domains of Grb2 and Grb7 (where Grb stands for growth-factor-receptor-bound protein). Glutathione S-transferase pull-down assays showed that the interaction of G6f with both Grb2 and Grb7 is mediated through the Src homology 2 domains of these two proteins and is dependent on the phosphorylation of G6f. Immunoprecipitation experiments showed the interaction of full-length phosphorylated G6f with both full-length Grb2 and Grb7. Antibody cross-linking of G6f expressed in K562 cells resulted in a transient phosphorylation of p42/44 MAP kinase (also known as extracellular-signal-regulated protein kinase-1/2; MAP stands for mitogen-activated protein) which could be prevented by MAP kinase kinase (MEK) inhibitors. These results suggest a coupling of G6f with downstream signal transduction pathways involving Grb2 and Grb7, including the Ras–MAP kinase pathway.

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2

Macaulay, Iain C., Marloes R. Tijssen, Daphne C. Thijssen-Timmer, Arief Gusnanto, Michael Steward, Philippa Burns, Cordelia F. Langford, et al. "Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins." Blood 109, no. 8 (December 27, 2006): 3260–69. http://dx.doi.org/10.1182/blood-2006-07-036269.

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AbstractTo identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared using cDNA microarrays. Bioinformatical analysis of MK–up-regulated genes identified 151 transcripts encoding transmembrane domain-containing proteins. Although many of these were known platelet genes, a number of previously unidentified or poorly characterized transcripts were also detected. Many of these transcripts, including G6b, G6f, LRRC32, LAT2, and the G protein–coupled receptor SUCNR1, encode proteins with structural features or functions that suggest they may be involved in the modulation of platelet function. Immunoblotting on platelets confirmed the presence of the encoded proteins, and flow cytometric analysis confirmed the expression of G6b, G6f, and LRRC32 on the surface of platelets. Through comparative analysis of expression in platelets and other blood cells we demonstrated that G6b, G6f, and LRRC32 are restricted to the platelet lineage, whereas LAT2 and SUCNR1 were also detected in other blood cells. The identification of the succinate receptor SUCNR1 in platelets is of particular interest, because physiologically relevant concentrations of succinate were shown to potentiate the effect of low doses of a variety of platelet agonists.

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3

Hughes, Craig E., Uvaraj P. Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M. Dijkstra, Pudur Jagadeeswaran, and Stephen P. Watson. "G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes." PLoS ONE 7, no. 12 (December 21, 2012): e52622. http://dx.doi.org/10.1371/journal.pone.0052622.

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4

COZZOLINO, SALVATORE, PAOLO CAPUTO, SERENA ACETO, ALEX WIDMER, and AMOTS DAFNI. "Speciation processes in Eastern Mediterranean Orchis s.l. species: Molecular evidence and the role of pollination biology." Israel Journal of Plant Sciences 49, no. 2 (January 1, 2001): 91–103. http://dx.doi.org/10.1560/qv6m-e7a0-qfc7-g6bl.

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5

Dahab, Mohamed F. "Treatment Alternatives for Nitrate Contaminated Groundwater Supplies." Journal of Environmental Systems 17, no. 1 (January 1, 1987): 65–75. http://dx.doi.org/10.2190/h1yg-g6f3-892m-9n2p.

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6

Juarez, Patricia, Scott T. Walters, Mikyta Daugherty, and Christopher Radi. "A Randomized Trial of Motivational Interviewing and Feedback with Heavy Drinking College Students." Journal of Drug Education 36, no. 3 (September 2006): 233–46. http://dx.doi.org/10.2190/753n-8242-727t-g63l.

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7

Yamanaka, Takashi, Ken Akashi, and Masayuki Ishii. "Stroke Rehabilitation and Long Leg Brace." Topics in Stroke Rehabilitation 11, no. 3 (July 2004): 6–8. http://dx.doi.org/10.1310/g8rf-312l-g6fw-a8jw.

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8

Akiyama, M. Michael, Hiroko Akiyama, and Carolyn C. Goodrich. "Spatial Development across the Life Span." International Journal of Aging and Human Development 21, no. 3 (October 1986): 175–85. http://dx.doi.org/10.2190/00xv-bvmx-g6fn-0lnn.

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Fifth graders, ninth graders, college students, and persons over age sixty-five were given three pencil-and-paper tasks in spatial development. Knowledge of Euclidean space was assessed in each of these three tasks. In Task 1, the participants were asked to draw water lines in tilted bottles on a horizontal stand. In Task 2, they were asked to draw water lines in tilted bottles on a tilted stand. In Task 3, they were asked to give directions from one place to another on a hypothetical map. The performance on Task 1 and 2 increased from fifth grade to college. The performance of the elderly was the same as the college students on Task 1, and less than the college students in Task 2. The elderly participants' performance on Task 3 was better than the other three age groups. These results were discussed in terms of ecological validity, experience, and the number of competing cues to be processed simultaneously. Piaget's formulation on adult cognitive development was used to explain the elderly's performance in relation to other groups [1].

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9

Badve, Sunil, and Edward R. Burns. "D-Dimer Measurements Unhelpful for Ruling In DIC." Laboratory Medicine 31, no. 7 (July 2000): 383–86. http://dx.doi.org/10.1309/5lcf-21kn-vvv0-g6ll.

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10

Fonseca, Vera Regina J. R. M., and Vera Silvia R. Bussab. "Self, other and dialogical space in autistic disorders." International Journal of Psychoanalysis 87, no. 2 (April 2006): 439–55. http://dx.doi.org/10.1516/6cn4-9c1h-g6pl-hmpk.

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11

García, Ángel, Yotis A. Senis, Robin Antrobus, Craig E. Hughes, Raymond A. Dwek, Steve P. Watson, and Nicole Zitzmann. "A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: Involvement of G6f, a novel platelet Grb2-binding membrane adapter." PROTEOMICS 6, no. 19 (October 2006): 5332–43. http://dx.doi.org/10.1002/pmic.200600299.

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12

Izquierdo, Irene, María N. Barrachina, Lidia Hermida-Nogueira, Vanessa Casas, Luis A. Morán, Serena Lacerenza, Roberto Pinto-Llorente, et al. "A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade." Thrombosis and Haemostasis 120, no. 02 (January 4, 2020): 262–76. http://dx.doi.org/10.1055/s-0039-3400295.

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AbstractC-type lectin-like receptor 2 (CLEC-2) plays a crucial role in different platelet-related physiological and pathological processes. It signals through a tyrosine kinase-mediated pathway that is highly dependent on the positive feedback exerted by the platelet-derived secondary mediators, adenosine diphosphate (ADP) and thromboxane A2 (TXA2). Here, we aimed to analyze the tyrosine phosphoproteome of platelets activated with the CLEC-2 agonist rhodocytin to identify relevant phosphorylated tyrosine residues (p-Tyr) and proteins involved in platelet activation downstream of this receptor. We identified 363 differentially p-Tyr residues, corresponding to the majority of proteins previously known to participate in CLEC-2 signaling and also novel ones, including adaptors (e.g., DAPP1, Dok1/3, CASS4, Nck1/2), kinases/phosphatases (e.g., FAK1, FES, FGR, JAK2, SHIP2), and membrane proteins (e.g., G6F, JAM-A, PECAM-1, TLT-1). To elucidate the contribution of ADP and TXA2 at different points of the CLEC-2 signaling cascade, we evaluated p-Tyr levels of residues identified in the analysis and known to be essential for the catalytic activity of kinases Syk(p-Tyr525+526) and Src(p-Tyr419), and for PLCγ2 activity (p-Tyr759). We demonstrated that Syk phosphorylation at Tyr525+526 also happens in the presence of ADP and TXA2 inhibitors, which is not the case for Src-pTyr419 and PLCγ2-pTyr759. Kinetics studies for the three phosphoproteins show some differences in the phosphorylation profile. Ca2+ mobilization assays confirmed the relevance of ADP and TXA2 for full CLEC-2-mediated platelet activation. The present study provides significant insights into the intracellular events that take place following CLEC-2 activation in platelets, contributing to elucidate in detail the CLEC-2 signalosome.

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13

García, A., Y. A. Senis, R. Antrobus, C. E. Hughes, S. C. Hughan, S. P. Watson, and N. Zitzmann. "IDENTIFICATION OF NOVEL TYROSINE PHOSPHORYLATED SIGNALLING PROTEINS FOLLOWING αIIbβ3-MEDIATED PLATELET SPREADING: INVOLVEMENT OF THE IMMUNOGLOBULIN SUPERFAMILY MEMBERS G6B-B AND G6F, AND THE NOVEL PLATELET ADAPTER DOK-3." Journal of Thrombosis and Haemostasis 5 (July 2007): P—M—259—P—M—259. http://dx.doi.org/10.1111/j.1538-7836.2007.tb01194.x.

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14

Ohashi, Ken, Fumio Takizawa, Norihiro Tokumaru, Chihaya Nakayasu, Hideaki Toda, Uwe Fischer, Tadaaki Moritomo, Keiichiro Hashimoto, Teruyuki Nakanishi, and Johannes Martinus Dijkstra. "A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes." Immunogenetics 62, no. 8 (July 8, 2010): 543–59. http://dx.doi.org/10.1007/s00251-010-0460-1.

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15

Yamada, Laís Akemi, Isabela Ramos Mariano, Vanessa Lara Rissi Sabino, Renan Soares Rabassi, Camila Bataglini, Silvia Carla Santana Ferreira Azevedo, Nayra Thais Delatorre Branquinho, Mirian Ayumi Kurauti, Rosângela Fernandes Garcia, and Maria Montserrat Diaz Pedrosa. "Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size." Nutrition & Metabolism 16, no. 1 (December 2019). http://dx.doi.org/10.1186/s12986-019-0413-0.

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Abstract Background Caloric restriction since birth changes glucose metabolism by the liver in overnight-fasted rats to a fed-like pattern, in which glucose output is large but gluconeogenesis is negligible. It was investigated whether these changes could be a residual effect of the nutritional condition during lactation and what could be the mechanism of such change. Methods Newborn Wistar rat pups were arranged in litters of 6 or 12 (G6 and G12). After weaning, the male pups were divided in: G6L and G12 L, fed freely until the age of 90 days (freely-fed groups); G6R and G12R, given 50% of the GL ingestion (food-restricted groups) until 90 days of age; G6RL and G12RL, given 50% of the GL ingestion until 60 days of age and fed freely until 90 days of age (refed groups). The experimental protocols were carried out at the age of 90 days after overnight fasting. Pairs of groups were compared through t test; other statistical comparisons were made with one-way ANOVA with Tukey post hoc text. Results Caloric restriction was effective in decreasing body and fat weights, total cholesterol and LDL. These effects were totally or partially reversed after 30 days of refeeding (groups GRL). During liver perfusion, the high glucose output of the GRs was further enhanced by adrenaline (1 μM), but not by lactate infusion. In contrast, in groups G6L, G12 L, G6RL and G12RL glycogenolysis (basal and adrenaline-stimulated glucose output) was low and gluconeogenesis from lactate was significant. A twofold increase in liver content of PKA in group G6R suggests that liver sensitivity to glucagon and adrenaline was higher because of caloric restriction, resulting in enhanced glucose output. Conclusions As glucose output was not affected by litter size, liver glucose metabolism in the adult rat, in contrast to other metabolic processes, is not a programmed effect of the nutritional condition during lactation. In addition, the increased expression of PKA points to a higher sensitivity of the animals under caloric restriction to glycogenolytic hormones, a relevant condition for glucose homeostasis during fasting.

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16

"Book Reviews." Journal of Individual Employment Rights 7, no. 1 (January 1, 1998): 87–89. http://dx.doi.org/10.2190/a4cm-0c2r-g6fj-6fnl.

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