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Dissertations / Theses on the topic 'GABAergic transmissioni'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

MAURI, MARIO. "Cellule staminali mesenchimali: potenziali modulatori del sistema nervoso centrale." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/39835.

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Bone marrow-derived mesenchymal stem cells (MSCs) account for a small population of cells of the non-hematopoietic component of bone marrow. MSCs are multipotent stem cells endowed with neurotrophic potential combined to immunological properties, making them a promising therapeutic tool for neurodegenerative disorders. Although the mechanisms by which they act are still largely unknown, trans-differentiation, paracrine and autocrine actions have been hypothesized. Here we focus on the study of the effects exerted by rat MSCs on CNS neurons and oligodendrocytes by using a simplified in vitro c

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2

Garden, Derek Leonard Frank. "GABAergic transmission in the perirhinal cortex in vitro." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274770.

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Mellor, Jack Robert. "Electrophysiological investigation of the mechanisms underlying GABAergic synaptic transmission." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624122.

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4

Fan, Kai Yoon. "GABAergic synaptic transmission, plasticity and integration in the subthalamic nucleus." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3167/.

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5

Diana, Marco Alberto. "Charakterisierung von einer retrograden Modulation inhibitorischer synaptischer Transmission im Kleinhirn der Ratte." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=971021988.

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6

Asseri, Khalid. "Effects of AMBD and isovaline on GABAergic transmission in thalamic neurons." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35078.

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In central neurons, the endogenous amino acid γ-aminobutyric acid (GABA) exerts synaptic inhibition mediated through ionotropic GABAA-, or metabotropic GABAB-receptors. These receptors exist on both pre- and postsynaptic membranes. The synthetic structural analogues of GABA, 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide (AMBD) and R-isovaline have received little study on synaptic inhibition in the mammalian thalamus. AMBD was originally proposed as a taurine antagonist whereas R-isovaline is a non-biogenic amino acid that increases postsynaptic K⁺ conductance of thalamocortica

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7

Cao, Zhiwen, and 曹志文. "GABAergic transmission in developmental establishment of a gravity-related spatial reference." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47151304.

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In rats, the subnuclei of the inferior olive (IO) and thalamus exist topographic spatial representation to sinusoidal horizontal linear translations along either the antero-posterior or interaural direction. To examine the effect of GABAergic neurotransmission within the vestibular nucleus on the establishment of gravity-related topographic spatial representation in relay station of the central vestibular pathway, GABAA receptor antagonist bicuculline was used to chronically perturb GABA transmission within the vestibular nucleus of postnatal rats. Implantation of bicuculline-loaded or salin

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8

Ma, Ying [Verfasser]. "Effects of enhancing GABAergic transmission on sleep-associated memory consolidation / Ying Ma." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2012. http://d-nb.info/1021331007/34.

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9

Antonelli, Roberta. "The role of prolyl-isomerase PIN1 in GABAergic and glutamatergic synaptic transmission." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4893.

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The correct functioning of the central nervous system relies on the rapid and efficient communication between neurons. This occurs at highly specialized functional points of contact called synapses. Synapses are extremely plastic in structure and function, strongly influenced by their own histories of impulse traffic and by signals from nearby cells. Synaptic contacts are fundamental to the development, homeostasis and remodeling of neural circuits. All these events are achieved through different mechanisms operating at both pre- and postsynaptic sites. At the level of the post synaptic densit

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10

Yuan, Ning. "DISTINCT MODULATORY EFFECTS OF DOPAMINE ON EXCITATORY CHOLINERGIC AND INHIBITORY GABAERGIC SYNAPTIC TRANSMISSION IN DROSOPHILA." Ohio University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1149001533.

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11

Seiscio, Andrew R. "The Role of GABAergic Transmission in Mediation of Striatal Local Field Potentials (LFPs)." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/psych_theses/63.

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In the present study, electrophysiological and behavioral effects of compromised Gama-Aminobutyric Acid (GABAergic) transmission were investigated in adult Rhesus macaque monkeys (N=2). GABAergic transmission was perturbed in the putamen by administration of a GABAa receptor antagonist, gabazine (10 and 500 μM), via a microdialysis-local field potential (MD-LFP) probe. Resultant changes in striatal local field potentials (LFPs) were measured as an assay of synchrony. Gabazine perfusion evoked discrete large amplitude spikes in LFPs in all subjects, and the frequency and shape of indi

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12

Ng, Ka-pak, and 吳嘉白. "Glutamatergic and GABAergic transmission regulate the maturation of vestibular circuitry for spatial recognition." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45200312.

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13

Piantadosi, Patrick Thomas. "Modulation of fear-related behaviors by prefrontal cortical GABAergic transmission and its relevance to schizophrenia." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44818.

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Individuals with schizophrenia are hypothesized to have a “noisy” prefrontal cortex (PFC), resulting from deficient gamma-aminobutyric acid (GABA) inhibitory neurotransmission. Given that the PFC regulates emotional functioning, it is possible that neuropathological alterations in PFC GABA function contribute to deficits in affective functioning in schizophrenia. In particular, schizophrenic patients have been suggested to apply aberrant motivational salience to cues, often being hyporesponsive to cues that predict reinforcement, and hyperresponsive to cues that do not predict reward. These ty

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14

Gabrielli, M. "ACTIVE ENDOCANNABINOIDS ARE RELEASED FROM MICROGLIA IN ASSOCIATION WITH EXTRACELLULAR VESICLES TO INHIBIT GABAERGIC TRANSMISSION." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/346707.

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Endocannabinoids (eCBs) are bioactive lipids which primarily influence synaptic communication within the nervous system. They are synthesized by neurons but also by microglia, especially under neuroinflammatory conditions. To exert their function, eCBs travel across the intercellular space. However, how eCBs move extracellularly remains obscure. Our recent evidence indicates that reactive microglia release extracellular vesicles (EVs), which may represent an ideal vehicle for the transport of hydrophobic eCBs. Hence, in this study we investigated whether microglial EVs carry eCBs and may influ

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15

Ayling, Martin D. T. "A computational analysis of the functional role of GABAergic synaptic transmission in striatal medium spiny neurons." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491856.

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Medium Spiny projection neurons, the sole output neurons of the striatum, are connected by GABAergic synapses. Such connections are classically assumed to be inhibitory, thus it has been suggested that one of the main functions of the striatum is to detect and classify cortical representations of sensory events to trigger appropriate motor responses through a winner-take-all network dynamic.

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16

Zheng, Thomas Wen-Juan. "Neurophysiological and pharmacological study of carbamazepine on physiological and pathological GABAergic-dependent thalamocortical oscillations." Strasbourg, 2010. http://www.theses.fr/2010STRA6131.

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La CBZ est un anticonvulsivant largement prescrit, utilisé dans le traitement des épilepsies focales et de troubles psychiatriques. Cependant, il est connu que son large spectre d'action sur différentes cibles moléculaires contribue à des effets secondaires communs et sévères. La CBZ interagit directement avec les récepteurs GABAA, qui jouent un rôle critique dans l’électrogenèse d’oscillations TC/CT physiologiques et pathologiques. Mon travail de thèse offre des arguments solides pour dire que la CBZ module les propriétés de décharge et d’oscillations des neurones thalamiques, au moins dans l

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17

Motsumori, Tomoyuki. "Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake." Kyoto University, 2012. http://hdl.handle.net/2433/152495.

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18

SAVARDI, ANNALISA. "Discovery and Characterization of Novel Selective NKCC1 Inhibitors for Down Syndrome and Brain Disorders with Depolarizing GABAergic Transmission." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/939823.

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Proper GABAergic transmission through Cl-permeable GABAA receptors is fundamental for physiological brain development and function. Indeed, defective GABAergic signaling -due to a high ratio of expression of the Cl importer NKCC1 and Cl exporter KCC2- has been implicated in several neurodevelopmental disorders (e.g., Down syndrome, DS). Interestingly, NKCC1 inhibition by the FDAapproved diuretic bumetanide reverts cognitive deficits in the TS65Dn mouse models of DS and core symptoms in a number of models of other brain disorders. However, the required chronic treatment with bumetanide is burde

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19

Zhang, Chuanqiang [Verfasser], Knut [Gutachter] Kirmse, Otto W. [Gutachter] Witte, and Valentin [Gutachter] Stein. "Role of depolarizing GABAergic transmission for cortical network development / Chuanqiang Zhang ; Gutachter: Knut Kirmse, Otto W. Witte, Valentin Stein." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/1206605057/34.

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20

Heise, C. "EUKARYOTIC ELONGATION FACTOR 2 KINASE DOWNREGULATES VESICLE RELEASE AND GABAERGIC TRANSMISSION BY TRANSLATION CONTROL OF A SUBSET OF PROTEINS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229422.

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eEF2K, also known as CAMKIII, is a highly regulated, ubiquitous kinase involved in the control of protein translation. In neurons, acute changes in eEF2K activity are associated with changes in synaptic proteome and function in vitro and in vivo. However, it is unclear what kind of synaptic proteomic and functional changes result from chronic alterations in eEF2K activity. Here we show that chronic eEF2K activity leads to a downregulation of vesicle release and the GABAergic system both in vitro and in vivo. Importantly, we show that eEF2K may be a potential target for the generation of antiep

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21

Spehl, Marco Simon [Verfasser], and Bela [Akademischer Betreuer] Szabo. "Analyse der Wirkung von CB1-Cannabinoidrezeptor-Antagonisten auf die GABAerge synaptische Transmission im Cerebellumcortex." Freiburg : Universität, 2013. http://d-nb.info/1123480192/34.

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22

Heubl, Martin. "Régulation rapide du co-transporteur neuronal K/Cl KCC2 par l'inhibition et l'excitation dans les neurones matures." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066073.

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La polarité et l'efficacité de la transmission GABAergique dépendent de la concentration intra-neuronale en chlore. Dans les neurones matures, le co-transporteur K+/Cl- KCC2 maintient la concentration intracellulaire en chlore à un niveau bas, permettant ainsi une réponse inhibitrice du GABA. En plus de son rôle dans la transmission GABAergique, KCC2 régule aussi l'efficacité de la transmission glutamatergique en contrôlant la spinogenèse, l'exocytose et la dynamique membranaire des récepteurs AMPA. Du fait de son importance aux synapses excitatrices et inhibitrices, il est crucial de comprend

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23

Kourdougli, Nazim. "Hippocampal structural reactive plasticity in a rat model of temporal lobe epilepsy : chloride homeostasis as a keystone." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4091.

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Cette thèse a pour objectif spécifique d’explorer les événements précoces pouvant être à l’origine du bourgeonnement aberrant des fibres moussues (FM) du gyrus denté, une réorganisation majeure dans l’Epilepsie du Lobe Tempora (ELT). Nous avons utilisé le modèle pilocarpine d’ELT chez le rat afin de montrer que la transmission GABAergique jouait un rôle prépondérant dans la formation des FM aberrantes au cours de l’épileptogenèse. Ceci étant due à une altération de l’homéostasie chlore, suite à une augmentation de l’expression du co-transporteur NKCC1 et une diminution du co-transporteur KCC2.

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Dik, Andre [Verfasser], and Weiqi [Akademischer Betreuer] Zhang. "Hemisphärenspezifische Wirkung von Erythropoetin auf die GABAerge Transmission in dem prälimbischen Cortex / Andre Dik ; Betreuer: Weiqi Zhang." Münster : Universitäts- und Landesbibliothek Münster, 2016. http://d-nb.info/1140169114/34.

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25

Werner, Christian [Verfasser], Claudia [Gutachter] Sommer, Marie-Christine [Gutachter] Dabauvalle, and Erhard [Gutachter] Wischmeyer. "Effect of autoantibodies targeting amphiphysin or glutamate decarboxylase 65 on synaptic transmission of GABAergic neurons / Christian Werner. Gutachter: Claudia Sommer ; Marie-Christine Dabauvalle ; Erhard Wischmeyer." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1108780873/34.

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26

BOLLA, MARIA. ""Investigation on the role of Cl- homeostasis and GABAergic transmission in sleep disorders of Down syndrome and in Prader Willi syndrome: a possible contributor to cognitive impairment"." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/996395.

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GABA is the main inhibitory neurotransmitter of the central nervous system (CNS). Recently, GABAergic transmission has been reported to be depolarizing and possibly excitatory rather than inhibitory in a number of neurodevelopmental disorders both in patients and mouse models. In particular, the Ts65Dn mouse model of Down syndrome (DS) exhibits depolarizing GABA due to upregulation of the Cl- importer NKCC1 both in the hippocampus and in the cortex. Moreover, NKCC1 inhibition by the FDA-approved diuretic bumetanide is able to rescue inhibitory GABAergic transmission, synaptic plas

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27

Zhu, Hongmei. "Prenatal dysfunctions of chloride-related inhibition in lumbar motoneurons of the SOD1G93A ALS." Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0026.

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La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative fatale de l’adulte caractérisée par la dégénérescence des motoneurones (MNs) et ayant une étiologie multifactorielle. La plupart des études sur la SLA se sont focalisées aux stades symptomatiques selon l’hypothèse que la pathogénicité apparaît lorsque la maladie devient symptomatique. Cependant, un nombre grandissant d’évidences indique que la pathogénicité se développerait bien avant les symptômes. Mon travail de thèse de Doctorat a été basé sur l’hypothèse selon laquelle la SLA – familiale et sporadique – découlerait

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28

Linder, Sophia [Verfasser], and Bela [Akademischer Betreuer] Szabo. "Klärung des Wirkmechanismus des Cannabinoid-Rezeptor-Antagonisten Rimonabant auf die GABAerge synaptische Transmission zwischen Interneuronen und Purkinjezellen im Cerebellum / Sophia Linder ; Betreuer: Bela Szabo." Freiburg : Albert-Ludwigs-Universität Freiburg, 2017. http://d-nb.info/112692086X/34.

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Höfelmann, Daniela [Verfasser], Gerhard K. [Akademischer Betreuer] Rammes, and Harald [Akademischer Betreuer] Luksch. "Mögliche Interaktionen des endocannabinoiden Systems mit dem 5-HT3-Rezeptor in der Amygdala : Untersuchungen zur Bedeutung für die Modulation der GABAergen synaptischen Transmission und Furchtkonditionierung / Daniela Höfelmann. Gutachter: Harald Luksch. Betreuer: Gerhard K. Rammes." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1025337719/34.

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30

Donato, Cristina. "Synaptic identity of neocortical circuits involving Martinotti cells in healthy conditions and in Down syndrome." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS079.pdf.

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Les interneurones GABAergiques du néocortex, englobent un grand nombre de types cellulaires: certains innervent la région périsomatique des neurones pyramidaux (NP), d'autres ciblent leurs dendrites. Ici, nous avons étudié la sous-unité alpha5 du récepteur GABAA(GABAAR), qui contribuerait significativement à l’inhibition tonique. Nous avons constaté que, dans les NP de la couche 2/3 du cortex somatosensoriel chez la souris, alpha5 a une contribution négligeable à l'inhibition tonique. Inversement nous avons montré qu’alpha5 est spécifiquement exprimée aux synapses dendritiques entre les cellul

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Zell, Vivien. "Impact des glucocorticoïdes circulants sur la maturation et le fonctionnement de l'inhibition spinale GABAergique." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ097/document.

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Les glucocorticoïdes (GC) sont des hormones stéroïdes synthétisées par les glandes surrénales. La production de ces GC est une des réponses de l’organisme pour rétablir l’homéostasie grâce à différentes actions comprenant des effets centraux sur le comportement et la douleur. C’est ce dernier qui a fait l’objet de mes travaux dans le cadre de cette thèse.Les afférences sensorielles primaires véhiculent les informations de la périphérie dans les cornes dorsales de la moelle épinière. Ces informations qui peuvent être nociceptives sont modulées par un réseau de neurones spinal avant d’être trans

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Özcan, Orçun Orkan. "Characterization of the Purkinje cell to nuclear cell connections in mice cerebellum." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ085/document.

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Le cervelet permet l’apprentissage moteur et la coordination des mouvements fins. Pour ce faire, il intègre les informations sensorielles provenant de l’ensemble du corps ainsi que les commandes motrices émises par d’autres structures du système nerveux central. Les noyaux cérébelleux profonds (DCN) constituent la sortie du cervelet et intègre les informations provenant des cellules de Purkinje (PC), des fibres moussues et des fibres grimpantes. Nous avons étudié les connexions fonctionnelles entres les PC et les DNC in vivo, grâce à une stimulation optogénétique des lobules IV/V du cortex cér

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Orcinha, Catarina Reis. "GABAergic transmission impairment promotes the glycinergic phenotype." Master's thesis, 2012. http://hdl.handle.net/10451/9222.

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Tese de mestrado em Bioquímica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012<br>A transmissão inibitória desempenha um papel importante na regulação e estabilização da actividade neuronal e é essencial para diversas funções cerebrais como a cognição, percepção, movimento e emoção. As sinapses inibitórias, GABAérgica e glicinérgica, e a sua distribuição, apresentam diferenças no sistema nervoso central dos mamíferos (CNS). A maioria das sinapses inibitórias no cérebro são GABAérgicas, e as glicinérgicas, predominantes na espinal medula e tronco cerebral, tem sido

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Huang, Yu-Yin, and 黃昱尹. "The Lamotrigine-Mediated Effect on Hippocampal GABAergic Transmission." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/44w2jv.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>105<br>Lamotrigine (LTG) is generally considered as a voltage-gated sodium (Nav) channel blocker, which can decrease neuronal excitability. However, recent studies suggest that LTG can also serve as a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel enhancer and can increase the excitability of GABAergic interneurons (INs). Perisomatic inhibitory INs, predominantly fast-spiking basket cells (BCs), powerfully inhibit granule cells (GCs) in the hippocampal dentate gyrus. Notably, BCs express abundant Nav channels and HCN channels, both of which are abl

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Rombo, Diogo Miguel Santos 1986. "Modulatory role of adenosine upon GABAergic transmission : consequences for excitability control." Doctoral thesis, 2015. http://hdl.handle.net/10451/22913.

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Tese de doutoramento, Ciências Biomédicas (Neurociências), Universidade de Lisboa, Faculdade de Medicina, 2015<br>Glutamatergic principal cell excitability in the hippocampus is regulated by local circuit neurons that release the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). These GABAergic interneurons exhibit vast structural, physiological and biochemical diversity, innervating both excitatory principal cells and other inhibitory interneurons. In the hippocampus, two classes of interneurons, the cholecystokinin (CCK)- and parvalbumin (PV)-containing neurons, are the most signif

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Morishita, Wade Katsuji. "Studies on GABAergic synaptic transmission in neurons of the deep cerebellar nuclei." Thesis, 1995. http://hdl.handle.net/2429/4783.

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In the cerebellum, the corticonuclear projection subserves as the major efferent pathway for the cerebellar cortical networks. This pathway, consists of a direct axonal projection from the Purkinje cells to the neurons of the deep cerebellar nuclei (DCN). It has been demonstrated both in vivo and in vitro that stimulation of the Purkinje cell axons exerts a powerful inhibitory influence on DCN neurons mediated by the neurotransmitter, ƴ-aminobutyric acid (GABA). However, despite the wealth of anatomical and biochemical information, few electrophysiological studies have been done to char

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Le, Gratiet Keyrian Louis. "Differential distribution of co-transmitted cholinergic and GABAergic synaptic inputs onto substantia nigra dopaminergic neurons." Thesis, 2021. http://hdl.handle.net/1828/12887.

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Neuronal communication in the mammalian brain relies on the presynaptic release of neurotransmitters which bind to ligand-gated ion channels found on postsynaptic neurons to modulate neuronal excitability. One such neurotransmitter is acetylcholine (ACh), a small molecule that is the signalling messenger of the cholinergic system. The cholinergic system is involved in a variety of behavioural functions including motor activity, sensory function, and higher executive commands. Dopaminergic neurons in the substantia nigra pars compacta (SNc) and the basal ganglia in general have long been implic

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Yang, Ming, and 明揚. "Reversal of Autistic-like Behaviors in the Cav3.2 Knockout Mice by Enhancing GABAergic Transmission." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/zhsfx4.

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Mei-Sen and 陳美森. "Role of GABAergic transmission in the vesicovascular reflex in normal and neonatal capsaicin-treated rats." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/76884605765604105745.

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碩士<br>中山醫學大學<br>醫學研究所<br>93<br>Role of GABAergic transmission in the vesicovascular reflex in normal and neonatal capsaicin-treated rats To clarify the effect of GABAergic transmission in the vesico-vascular reflex (VVR). We investigated changes in blood pressure (BP) during bladder isovolumic contractions in normal and neonatal capsaicin-treated rats. In normal rats, intrathecal injection of GABA (20

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Werner, Christian. "Effect of autoantibodies targeting amphiphysin or glutamate decarboxylase 65 on synaptic transmission of GABAergic neurons." Doctoral thesis, 2014. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-105648.

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The number of newly detected autoantibodies (AB) targeting synaptic proteins in neurological disorders of the central nervous system (CNS) is steadily increasing. Direct interactions of AB with their target antigens have been shown in first studies but the exact pathomecha-nisms for most of the already discovered AB are still unclear. The present study investigates pathophysiological mechanisms of AB-fractions that are associated with the enigmatic CNS disease Stiff person syndrome (SPS) and target the synaptically located proteins amphiphysin or glutamate decarboxylase 65 (GAD65). In the firs

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Chudomel, Ondřej. "Age and sex differences in GABAergic transmission in the substantia nigra pars reticulata in the rat." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-348939.

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Many experimental as well as clinical studies have shown that subcortical neuronal circuitries including the anterior part of the substantia nigra pars reticulata (SNR) are closely involved in the control of seizures propagation and termination. In vivo studies in rats demonstrated that inhibition of the GABAergic SNRA electrical output increases the seizure threshold in the flurothyl model of generalized clonic seizures. The anticonvulsant properties of the SNRA are largely age- and sex-depended. In the current experiments were used 3 age groups of Sprague Dawley rats (PN5-9, PN11-16 and PN25

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Engler, Birgit. "Wirkung von Cannabinoiden auf die GABAerge Neurotransmission zwischen Caudato-Putamen und Globus pallidus /." 2005. http://www.gbv.de/du/services/toc/bs/493375503.

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Astori, Simone [Verfasser]. "Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk / presented by Simone Astori." 2006. http://d-nb.info/982426062/34.

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Keipert, Christine [Verfasser]. "Untersuchungen zur muskarinischen Modulation der GABAergen Transmission im Colliculus inferior der juvenilen Ratte / von Christine Keipert." 2006. http://d-nb.info/978096282/34.

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Chang, Ting-Hsuan Daniel, and 張珽瑄. "Comparison of Transmission at Synapses of Layers 2/3 Input onto Layer 5 Pyramidal and GABAergic Neurons in Rostral Agranular Insular Cortex." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/93585570272002491439.

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碩士<br>國立臺灣大學<br>生命科學系<br>104<br>It has been shown that inhibition or lesion of the rostral agranular insular cortex (RAIC) results in analgesia, it suggests that RAIC tonically produces hyperalgesia signal. RAIC is a cortical area where nociceptive output originates, and it has been reported to activate in chronic pain perception. It’s believed that chronic pain is associated with the long-term change in synaptic plasticity. Moreover, the imbalance of excitatory and inhibitory (E/I) synaptic signaling in neural circuits is responsible to modulate synaptic plasticity in certain behavior disorde

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Lin, Bei-Xuan, and 林蓓萱. "Synaptic Transmission of GABAergic Interneurons on Layer 5 Pyramidal Neurons in the Rostral Agranular Insular Cortex of Control and Muscle Pain Mice." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/45mghz.

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碩士<br>國立臺灣大學<br>生命科學系<br>105<br>It has been well demonstrated that the change of synaptic efficacy in neurocircuit of brain pain matrix is a cellular substrate for behavior hypersensitivity in animals with chronic pain. While most of previous studies focus on transmission at synapses between nociceptive inputs and principal neurons, the role of local GABAergic interneurons (IntNs) receives less attention. I address this issue by using the acid-induced muscle pain animal model (AIMP model) in mice and focusing on the rostral agranular insular cortex (RAIC). The RAIC is an important component of

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Kirmse, Knut [Verfasser]. "Die GABAerge synaptische Transmission auf Cajal-Retzius-Zellen des visuellen Kortex der Maus / von Knut Kirmse." 2007. http://d-nb.info/987994190/34.

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Xing, Paul. "Implication de Syngap1 dans la transmission GABAergique et la plasticité synaptique." Thèse, 2015. http://hdl.handle.net/1866/13793.

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La déficience intellectuelle affecte de 1 à 3% de la population mondiale, ce qui en fait le trouble cognitif le plus commun de l’enfance. Notre groupe à découvert que des mutations dans le gène SYNGAP1 sont une cause fréquente de déficience intellectuelle non-syndromique, qui compte pour 1-3% de l’ensemble des cas. À titre d’exemple, le syndrome du X fragile, qui est la cause monogénique la plus fréquente de déficience intellectuelle, compte pour environ 2% des cas. Plusieurs patients affectés au niveau de SYNGAP1 présentent également des symptômes de l’autisme et d’une forme d’épilepsie. Notr

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Walter, Jan [Verfasser]. "Glutamaterge Modulation der GABAergen synaptischen Transmission durch metabotrope Glutamatrezeptoren der Gruppe I sowie deren Einfluss auf die Synaptogenese in Hirnschnittpräparaten / von Jan Walter." 2006. http://d-nb.info/983750432/34.

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