Academic literature on the topic 'Galactofuranosides'

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Journal articles on the topic "Galactofuranosides"

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Predescu, Nicoleta Florentina, Silvia Iga, Alina Nicolescu, and Dumitru Petru Iga. "Koenigs-Knorr Synthesis of Galactofuranosides of Estrone, Androstanolone, 11a-Hydroxyprogesterone and Prednisolone." Revista de Chimie 59, no. 1 (2008): 52–55. http://dx.doi.org/10.37358/rc.08.1.1706.

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Galactofuranosylation has been accomplished with 1-bromo-1-deoxy-2,3,5,6-tetra-O-benzoyl-a-D-galactofuranoside in the presence of cadmium carbonate as promotor. Glycosylation agent has been prepared by bromination of penta-O-benzoyl-ab-D-galactofuranoside with a solution of hydrogen bromide in glacial acetic acid. The precursor of the latter reaction has been produced by benzoylation of D-galactose that had been heated in pyridine while still warm. The following hydroxysteroids have been selected as being representative in terms of configuration, type of hybridization of carbon bearing hydroxy
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Completo, Gladys C., Reymart V. Sangalang, Beatrice M. I. Pique, and Ruel C. Nacario. "Simple and Efficient Method for the Synthesis of Galactofuranosides." KIMIKA 27, no. 2 (2017): 38–49. http://dx.doi.org/10.26534/kimika.v27i2.38-49.

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An efficient and improved one-pot method for the synthesis of galactofuranosides via iodine-promoted cyclization of galactose diethyl dithioacetal in the presence of alcohol, acting both as solvent and nucleophile, is described. The reaction is carried out at room temperature. Alcohols, such as methanol, cyclohexanol and tert-butanol, were used as nucleophiles for the reaction using 2%, 3% and 5% iodine promoter, respectively. A key finding in this study was that the iodine-promoted cyclization of galactose diethyl dithioacetal with alcohol led to selective formation of β-galactofuranoside all
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Marino, C., K. Marino, L. Miletti, M. J. Manso Alves, W. Colli, and R. M. de Lederkremer. "1-Thio- -D-galactofuranosides: synthesis and evaluation as -D-galactofuranosidase inhibitors." Glycobiology 8, no. 9 (1998): 901–4. http://dx.doi.org/10.1093/glycob/8.9.901.

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Mariño, Karina, Carla Marino та Rosa M. de Lederkremer. "Specific Tritium Labeling of β--Galactofuranosides at the 6-Position: A Tool for β--Galactofuranosidase Detection". Analytical Biochemistry 301, № 2 (2002): 325–28. http://dx.doi.org/10.1006/abio.2001.5508.

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Bordoni, Andrea, Rosa M. de Lederkremer та Carla Marino. "Synthesis of 5-deoxy-β-d-galactofuranosides as tools for the characterization of β-d-galactofuranosidases". Bioorganic & Medicinal Chemistry 18, № 14 (2010): 5339–45. http://dx.doi.org/10.1016/j.bmc.2010.05.038.

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Frigell, Jens, and Ian Cumpstey. "Synthesis of carbadisaccharide mimics of galactofuranosides." Tetrahedron Letters 50, no. 36 (2009): 5142–44. http://dx.doi.org/10.1016/j.tetlet.2009.06.115.

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Frigell, Jens, та Ian Cumpstey. "Carbasugar analogues of galactofuranosides: α-O-linked derivatives". Beilstein Journal of Organic Chemistry 6 (29 листопада 2010): 1127–31. http://dx.doi.org/10.3762/bjoc.6.129.

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Using an indirect method, we have synthesised α-linked carbasugar analogues of galactofuranosides for the first time. Ring opening of a β-talo configured carbasugar 1,2-epoxide by alcohol nucleophiles under Lewis acidic conditions proceeded with very good regioselectivity to give α-talo configured C1-substituted ethers with a free OH-group at the C2 position. Inversion of configuration at C2 by an oxidation–reduction sequence gave the α-galacto configured carbahexofuranose C1 ethers. A carbadisaccharide corresponding to the Galf(α1→3)Manp substructure from Apodus deciduus galactomannan was syn
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Mariño, Karina, and Carla Marino. "Synthesis of heteroaryl 1-thio-ß-D-galactofuranosides and evaluation of their inhibitory activity towards a ß-D-galactofuranosidase." Arkivoc 2005, no. 12 (2006): 341–51. http://dx.doi.org/10.3998/ark.5550190.0006.c27.

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Suleman, Muhammad, Jean-Pierre Gangneux, Laurent Legentil, et al. "Alkyl Galactofuranosides Strongly Interact with Leishmania donovani Membrane and Provide Antileishmanial Activity." Antimicrobial Agents and Chemotherapy 58, no. 4 (2014): 2156–66. http://dx.doi.org/10.1128/aac.01350-13.

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ABSTRACTWe investigated thein vitroeffects of four alkyl-galactofuranoside derivatives, i.e., octyl-β-d-galactofuranoside (compound 1), 6-amino-β-d-galactofuranoside (compound 2), 6-N-acetamido-β-d-galactofuranoside (compound 3), and 6-azido-β-d-galactofuranoside (compound 4), onLeishmania donovani. Their mechanism of action was explored using electron paramagnetic resonance spectroscopy (EPR) and nuclear magnetic resonance (NMR), and ultrastructural alterations were analyzed by transmission electron microscopy (TEM). Compound 1 showed the most promising effects by inhibiting promastigote grow
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Masui, Seiji, Yoshiyuki Manabe, Kohtaro Hirao, et al. "Kinetically Controlled Fischer Glycosidation under Flow Conditions: A New Method for Preparing Furanosides." Synlett 30, no. 04 (2019): 397–400. http://dx.doi.org/10.1055/s-0037-1611643.

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Kinetically controlled Fischer glycosidation was achieved under flow conditions. β-Hydroxy-substituted sulfonic acid functionalized silica (HO-SAS) was used as an acid catalyst. This reaction directly converted aldohexoses into kinetically favored furanosides to enable the practical synthesis of furanosides. After optimization of the reaction temperature and residence time, glucofuranosides, galactofuranosides, and mannofuranosides were synthesized in good yields.
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Dissertations / Theses on the topic "Galactofuranosides"

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Vaugenot, Jeane. "Plateforme modulable pour le développement de glycolipides à potentiel immunoadjuvant." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1S098.

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L’évolution constante des vaccins a mené les chercheurs à se concentrer sur l’injection de fragments antigéniques toujours plus petits. Des immunoadjuvants sont ajoutés aux formulations dans le but d’augmenter l’intensité et la durée de la réponse immunitaire. Les glycolipides sont des composés qui possèdent des propriétés immunoadjuvantes puisqu’ils peuvent transporter des agents thérapeutiques et /ou interagir avec les cellules du système immunitaire. Les lipides d’Archaea sont connus pour leur grande stabilité et leur capacité à former des archaeosomes qui activent les réponses immunitaires
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Frigell, Jens. "Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-43561.

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In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M.tuberculosis, responsible for the disease tuberculosis, has a cell wall containing a repeating unit of alternating (1→5)- and (1→6)-linked β-D-galactofuranosyl residues. Synthetic inhibitors of the enzymes involved in the biosynthesis of the cell wall could find great therapeutic use.
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Liautard, Virginie. "Conception et synthèse d'imino-C-galactofuranosides comme inhibiteurs de la biosynthèse des galactanes mycobactériens." Phd thesis, Université d'Orléans, 2008. http://tel.archives-ouvertes.fr/tel-00418214.

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Dans le contexte de la recherche de molécules actives agissant spécifiquement sur des microorganismes pathogènes tels que les mycobactéries, la biosynthèse du galactofuranose (Galf) constitue une cible chimiothérapeutique intéressante. Notre approche consiste à concevoir et synthétiser des iminosucres originaux comme inhibiteurs potentiels et/ou sondes mécanistiques des enzymes mises en jeu : l'UDP-Galp mutase (UGM) et les Galf transférases (GlfT). Pour cela nous avons développé deux approches stéréodivergentes conduisant à des imino-C-galactosides originaux.<br>Nous avons mis au point une mét
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Cabezas, Yari. "Vers le développement d’outils diagnostiques et thérapeutiques contre la leishmaniose. Approches régiosélectives et chimio-enzymatiques pour la synthèse d’oligosaccharides leishmaniens." Rennes, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCR0024.

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Les leishmanioses affectent chaque année près de 2 millions de personnes dans le monde. Une cible d’intérêt a été découverte dans le glycocalyx du parasite : le LPG, qui semble jouer un rôle important pour sa survie, sa virulence et dans les interactions hôte-parasite. Il est à noter que cet oligosaccharide possède des unités β-D-Galf, motif totalement absent chez les mammifères. Ainsi, la synthèse de mimes du LPG contenant des motifs Galf pourrait conduire à la fabrication de sondes diagnostiques spécifiques au parasite, mais aussi à l’émergence de nouveaux traitements. Au cours de ce travail
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Han, Jeong-Seok. "Studies towards the identification of mycobacterial cell wall biosynthesis inhibitors and synthetic studies of buergerinin F, buergerinin G, and feigrisolide B." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1063903422.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 395 p.; also includes graphics Includes bibliographical references (p. 383-395). Available online via OhioLINK's ETD Center
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Belaz, Sorya. "Dérivés furanosidiques à visée thérapeutique dans la leishmaniose : caractérisation des effets et mode d'action." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B044/document.

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La leishmaniose est une maladie tropicale négligée pour laquelle l’arsenal thérapeutique actuel est limité. Ce travail de thèse s’est intéressé à rechercher des nouvelles cibles thérapeutiques en ciblant la paroi des leishmanies. Le lipophosphoglycane (LPG), constituant majoritaire de la paroi, présente un motif glucidique particulier, le galactofuranose, qui semble une cible thérapeutique intéressante car il est absent des membranes de mammifères. Les galactofuranosyl-transférases sont impliquées dans le métabolisme de ce furanose, et ce travail a débuté par l’étude de ces enzymes et par la c
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Books on the topic "Galactofuranosides"

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Tuekam, Brigitte Albertine. Isolation, purification and characterization of Penicillium charlesii G. Smith exo- ø-galactofuranosidase. 1993.

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Book chapters on the topic "Galactofuranosides"

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"Synthesis of 5-Deoxy-β-d-galactofuranosides (5-Deoxy-α-l- arabino-hexofuranosides) Starting from d-Galacturonic Acid Using Photoinduced Electron Transfer Deoxygenation." In Carbohydrate Chemistry. CRC Press, 2015. http://dx.doi.org/10.1201/b18400-13.

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"Isorhamnetin-3-O-β-D-galactofuranoside." In Natural Compounds. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_500.

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Marino, Carla, Santiago Poklepovich Caridea, Rosa M. de Lederkremer, and Sydney Villaume. "Synthesis of 4-Nitrophenyl β-d-galactofuranoside." In Carbohydrate Chemistry. CRC Press, 2017. http://dx.doi.org/10.1201/9781315120300-11.

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"Improved Synthesis of Ethyl 1-Thio-α-d-galactofuranoside." In Carbohydrate Chemistry. CRC Press, 2015. http://dx.doi.org/10.1201/b18400-24.

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"Methyl(Ethyl 2,3,5-Tri-O-Benzoyl-1-Thio-α,β-d- Galactofuranosid)uronate." In Carbohydrate Chemistry. CRC Press, 2016. http://dx.doi.org/10.1201/b11261-43.

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