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Journal articles on the topic 'Galactose-α1'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Quinn, Gary, James C. Wood, David J. J. Ryan та ін. "Porcine Endogenous Retrovirus Transmission Characteristics of Galactose α1-3 Galactose-Deficient Pig Cells". Journal of Virology 78, № 11 (2004): 5805–11. http://dx.doi.org/10.1128/jvi.78.11.5805-5811.2004.

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ABSTRACT Galactose α1-3 galactose (Gal) trisaccharides are present on the surface of wild-type pig cells, as well as on viruses particles produced from such cells. The recognition of Gal sugars by natural anti-Gal antibodies (NAb) in human and Old World primate serum can cause the lysis of the particles via complement-dependent mechanisms and has therefore been proposed as an important antiviral mechanism. Recently, pigs have been generated that possess disrupted galactosyl-transferase (GGTA1) genes. The cells of these pigs do not express Gal sugars on their surface, i.e., are Gal null. Concer

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Senior, David F., Peter deMan, and Catharina Svanborg. "Serotype, hemolysin production, and adherence characteristics of strains of Escherichia coli causing urinary tract infection in dogs." American Journal of Veterinary Research 53, no. 4 (1992): 494–98. http://dx.doi.org/10.2460/ajvr.1991.53.04.494.

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Summary Virulence factors were studied in 82 strains of Escherichia coli isolated from the urine of dogs with urinary tract infections. The most frequently expressed O antigens were 2, 4, 6, 25, and 22/83. Most strains were K nontypeable. Mannose-sensitive hemagglutination (msh) with canine erythrocytes was observed in 71 strains and mannose-resistant hemagglutination (mrh) was observed in 32 strains. Strains that caused msh of erythrocytes from dogs also caused msh of erythrocytes from guinea pigs. Most strains that caused mrh of human A1p1 erythrocytes also reacted with erythrocytes of dogs.

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Gabrielli, Armando, Pietro Leoni, Giovanni Danieli, Konrad Herrmann, Thomas Krieg та Jorgen Wieslander. "Antibodies against galactosyl (α1→3) galactose in connective tissue diseases". Arthritis & Rheumatism 34, № 3 (1991): 375–76. http://dx.doi.org/10.1002/art.1780340321.

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Lee, Chan Hyoung, Hee Taek Kim, Eun Ju Yun та ін. "A Novel Agarolytic β-Galactosidase Acts on Agarooligosaccharides for Complete Hydrolysis of Agarose into Monomers". Applied and Environmental Microbiology 80, № 19 (2014): 5965–73. http://dx.doi.org/10.1128/aem.01577-14.

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ABSTRACTMarine red macroalgae have emerged to be renewable biomass for the production of chemicals and biofuels, because carbohydrates that form the major component of red macroalgae can be hydrolyzed into fermentable sugars. The main carbohydrate in red algae is agarose, and it is composed ofd-galactose and 3,6-anhydro-l-galactose (AHG), which are alternately bonded by β1-4 and α1-3 linkages. In this study, a novel β-galactosidase that can act on agarooligosaccharides (AOSs) to release galactose was discovered in a marine bacterium (Vibriosp. strain EJY3); the enzyme is annotated asVibriosp.

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Li, Jun, Hui-Chen Hsu, Ping-Ar Yang, Qi Wu, and John Mountz. "Fucosylation regulates cell death in rheumatoid arthritis (87.24)." Journal of Immunology 184, no. 1_Supplement (2010): 87.24. http://dx.doi.org/10.4049/jimmunol.184.supp.87.24.

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Abstract Abnormal inflammation and apoptosis are major pathogenic features of synovial fibroblasts (SF) in rheumatoid arthritis (RA). Fucosylation, an important type of glycosylation, has been identified in cancer and inflammation conditions. The role of fucosylation in RA was investigated. Real-time PCR indicated that between RASF and osteoarthritis (OA) SF (N=14 each), there was no difference in the expression of apoptosis related molecules, including tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), its receptors DR4, DR5, DR6, DcR1, DcR2, and regulators of apoptosis FL

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6

Hung, Le Dinh, and Le Thi Doan Thuc. "High-mannose type N-glycan binding specificity of a novel lectin from the red alga (Betaphycus gelatinus)." Vietnam Journal of Biotechnology 17, no. 4 (2020): 709–18. http://dx.doi.org/10.15625/1811-4989/17/4/13697.

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The red alga, Betaphycus gelatinus is one of carrageenan sources in the world. The lectin from the red alga B. gelatinus was isolated by a combination of aqueous ethanol extraction, ethanol precipitation, ion-exchange chromatography and gel filtration chromatography and was designated as BGL after the specific name of alga. Lectin gave a single band with molecular mass of about 19,000 Da in both non-reducing and reducing SDS-PAGE conditions, therefore lectin exists in monomer form. The hemagglutination activities of BGL were stable over a wide range of pH from 3 to 10, temperature up 60 oC and

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LAUDER, M. Robert, N. Thomas HUCKERBY, A. Ian NIEDUSZYNSKI, and H. K. Anna PLAAS. "Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage." Biochemical Journal 330, no. 2 (1998): 753–57. http://dx.doi.org/10.1042/bj3300753.

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Bovine articular cartilage fibromodulin has been isolated from animals aged 3 months to 8 years, and the attached keratan sulphate (KS) chains digested with keratanase II. The oligosaccharides generated have been reduced, examined by high-pH anion-exchange chromatography and their structures identified by comparison with standards. It has been shown that in fibromodulin from young articular cartilage, the KS chains do not possess either non-reducing terminal (α2-6)-linked N-acetylneuraminic acid or fucose (α1-3)-linked to sulphated N-acetylglucosamine residues. However, an age-related increase

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8

Manez, R., I. Diaz, A. Centeno та ін. "Sustained decrease of serum anti-galactose α1–3-galactose antibodies in baboons by removing aerobic gram-negative bacteria from the bowel". Transplantation Proceedings 31, № 1-2 (1999): 947–48. http://dx.doi.org/10.1016/s0041-1345(98)01849-1.

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9

Ishida, Momoko, Rika Ohara, Fuka Miyagawa, et al. "Umbelliferose Isolated from Cuminum cyminum L. Seeds Inhibits Antigen-Induced Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells." Molecules 27, no. 13 (2022): 4101. http://dx.doi.org/10.3390/molecules27134101.

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Cuminum cyminum L. (cumin) is an annual plant of the Umbelliferae family native to Egypt. We previously showed that the aqueous extract of cumin seeds suppresses degranulation by downregulating the activation of antigen-induced intracellular signaling molecules in rat basophilic leukemia RBL-2H3 cells. However, the active substances in the extract have not yet been identified. Accordingly, herein, we aimed to ascertain the water-soluble substances present in cumin seeds that inhibit degranulation, which led to the identification of umbelliferose, a characteristic trisaccharide present in plant

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10

Lew, L. C., Y. Y. Hor, M. H. Jaafar, et al. "Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats." Beneficial Microbes 10, no. 8 (2019): 883–92. http://dx.doi.org/10.3920/bm2019.0058.

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This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5’adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Administration of statin, Lactobacillu

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11

Dinh Hung, Le, Tran Thi Hai Yen, and Dinh Thanh Trung. "Characterization of O-glycan binding lectin from the red alga Hydropuntia eucheumatoides." Vietnam Journal of Biotechnology 16, no. 4 (2020): 687–96. http://dx.doi.org/10.15625/1811-4989/16/4/13056.

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The red alga, Hydropuntia eucheumatoides is one of the algal genera from which agar is commercially extracted, and is the main source of agar in the world. The lectin HEL from the red alga H. eucheumatoides was isolated by a combination of aqueous ethanol extraction, ethanol precipitation, ion exchange and filtration chromatography. Lectin gave a single band with molecular mass of 17,000 Da in both non-reducing and reducing SDS-PAGE conditions, therefore lectin exists in monomeric form. The hemagglutination activities of HEL were stable over a wide range of pH from 3 to 10, temperature up 60 o

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12

Nakahashi, Hiromitsu, Tatsuya Oda, Osamu Shimomura, et al. "Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations." Journal of Oncology 2024 (March 18, 2024): 1–12. http://dx.doi.org/10.1155/2024/1529449.

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Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC patients were digested and embedded into a 3D culture system

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13

Itakura, Yoko, Norihiko Sasaki, and Masashi Toyoda. "Glycan characteristics of human heart constituent cells maintaining organ function: relatively stable glycan profiles in cellular senescence." Biogerontology 22, no. 6 (2021): 623–37. http://dx.doi.org/10.1007/s10522-021-09940-z.

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AbstractCell surface glycoproteins, which are good indicators of cellular types and biological function; are suited for cell evaluation. Tissue remodeling using various cells is a key feature of regenerative therapy. For artificial heart remodeling, a mixture of heart constituent cells has been investigated for organ assembly, however, the cellular characteristics remain unclear. In this study, the glycan profiles of human cardiomyocytes (HCMs), human cardiac fibroblasts (HCFs), and human vascular endothelial cells (ECs) were analyzed using evanescent-field lectin microarray analysis, a tool o

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14

Kouki, Annika, Sauli Haataja, Vuokko Loimaranta, Arto T. Pulliainen, Ulf J. Nilsson та Jukka Finne. "Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-α1–4-galactose-containing Glycoconjugates". Journal of Biological Chemistry 286, № 45 (2011): 38854–64. http://dx.doi.org/10.1074/jbc.m111.260992.

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15

Yamauchi, Mitsuo, and Marnisa Sricholpech. "Lysine post-translational modifications of collagen." Essays in Biochemistry 52 (May 25, 2012): 113–33. http://dx.doi.org/10.1042/bse0520113.

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Type I collagen is the most abundant structural protein in vertebrates. It is a heterotrimeric molecule composed of two α1 chains and one α2 chain, forming a long uninterrupted triple helical structure with short non-triple helical telopeptides at both the N- and C-termini. During biosynthesis, collagen acquires a number of post-translational modifications, including lysine modifications, that are critical to the structure and biological functions of this protein. Lysine modifications of collagen are highly complicated sequential processes catalysed by several groups of enzymes leading to the

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16

Seo, Ho Seong, Robert T. Cartee, David G. Pritchard, and Moon H. Nahm. "A New Model of Pneumococcal Lipoteichoic Acid Structure Resolves Biochemical, Biosynthetic, and Serologic Inconsistencies of the Current Model." Journal of Bacteriology 190, no. 7 (2008): 2379–87. http://dx.doi.org/10.1128/jb.01795-07.

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ABSTRACT Lipoteichoic acid (LTA) is an essential bacterial membrane polysaccharide (cell wall component) that is attached to the membrane via a lipid anchor. According to the currently accepted structure of pneumococcal LTA, the polysaccharide is comprised of several repeating units, each of which starts with glucose and ends with ribitol, with the lipid anchor predicted to be Glc(β1→3)AATGal(β1→3)Glc(α1→3)-acyl2Gro, where AATGal is 2-acetamido-4-amino-2,4,6-trideoxy-d-galactose. However, this lipid anchor has not been detected in pneumococcal membranes. Furthermore, the currently accepted str

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Hernàndez, Dimas E., Aaron Cohen, Denisse Fisher, Marı̀a Correnti та Ricardo Harner. "Antibody Levels against Galactosyl (α1 → 3) Galactose Epitopes in Cervical Mucus from Patients with Human Papillomavirus Infection". Gynecologic Oncology 84, № 3 (2002): 374–77. http://dx.doi.org/10.1006/gyno.2001.6516.

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18

Shihab, Elaf M., and Haitham M. Kadhim. "The Impact of Carvedilol on Organ Index, Inflammatory Mediators, Oxidative Stress Parameters and Skin Markers in D-Galactose-Induced Aging Mice." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 1017–23. http://dx.doi.org/10.25258/ijddt.13.3.41.

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Background: Aging processes are defined as those that increase the susceptibility of individuals, as they grow older, to the factors that eventually lead to death. It is a complex multi-factorial process where several factors may interact simultaneously and may operate at many levels of functional organization.. Accumulating evidence has suggested that active ingredients that possess antioxidative and anti-inflammatory proprties could decrease the incidence and development of aging-related diseases and promote longevity. Carvedilol is a non-selective third generation β-blocker/α1-blocker with

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19

Tikkanen, Kaarina, Sauli Haataja, Christiane François-Gerard та Jukka Finne. "Purification of a Galactosyl-α1-4-galactose-binding Adhesin from the Gram-positive Meningitis-associated Bacterium Streptococcus suis". Journal of Biological Chemistry 270, № 48 (1995): 28874–78. http://dx.doi.org/10.1074/jbc.270.48.28874.

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20

Klein, Reinhild, Rupert Timpl, Dietrich Plester, Fortunato R. Zanetti та Peter A. Berg. "High Antibody Levels against Mouse Laminin with Specificity for Galactosyl-(α1–3)Galactose in Patients with Inner Ear Diseases". Annals of Otology, Rhinology & Laryngology 98, № 7 (1989): 537–42. http://dx.doi.org/10.1177/000348948909800708.

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Sera of 413 patients with inner ear diseases were examined for ELISA binding to mouse laminin and compared to a normal group. Strongly enhanced antilaminin antibody reactions were observed in a large number of patients with sensorineural hearing loss (68%), tinnitus (60%), and sudden deafness (46%), but not in those with Meniere's disease (14%) or normal individuals (8%). Absorption experiments demonstrated that these antibodies are also responsible for the antisarcolemmal antibody pattern in the immunofluorescence test and for the reaction with pig kidney microsomes in the ELISA. Immunochemic

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21

Yang, Jinghua, Mary Ritchey, Yasuo Yoshida, C. Allen Bush, and John O. Cisar. "Comparative Structural and Molecular Characterization of Ribitol-5-Phosphate-Containing Streptococcus oralis Coaggregation Receptor Polysaccharides." Journal of Bacteriology 191, no. 6 (2009): 1891–900. http://dx.doi.org/10.1128/jb.01532-08.

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ABSTRACT The antigenically related coaggregation receptor polysaccharides (RPS) of Streptococcus oralis strains C104 and SK144 mediate recognition of these bacteria by other members of the dental plaque biofilm community. In the present study, the structure of strain SK144 RPS was established by high resolution NMR spectroscopy as [6Galfβ1-6GalNAcβ1-3Galα1-2ribitol-5-PO4 −-6Galfβ1-3Galβ1]n, thereby indicating that this polysaccharide and the previously characterized RPS of strain C104 are identical, except for the linkage between Gal and ribitol-5-phosphate, which is α1-2 in strain SK144 versu

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Aoyama, Michihiko, Noritaka Hashii, Wataru Tsukimura та ін. "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies". mAbs 11, № 5 (2019): 826–36. http://dx.doi.org/10.1080/19420862.2019.1608143.

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23

Reynard, Olivier, Frédéric Jacquot, Gwénaëlle Evanno та ін. "Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs". PLOS ONE 11, № 6 (2016): e0156775. http://dx.doi.org/10.1371/journal.pone.0156775.

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Neprasova, Michaela, Dita Maixnerova, Jan Novak, et al. "Toward Noninvasive Diagnosis of IgA Nephropathy: A Pilot Urinary Metabolomic and Proteomic Study." Disease Markers 2016 (October 9, 2016): 1–9. http://dx.doi.org/10.1155/2016/3650909.

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IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as source of biomarkers of IgA nephropathy. We used spot urine specimens from 19 healthy controls, 11 patients with IgA nephropathy, and 8 renal-disease controls collected on day of renal biopsy. Urine samples were analyzed using untargeted metabolomic and targeted proteomic analyses

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KARAIVANOVA, K. Velislava, and G. Robert SPIRO. "Sulphation of N-linked oligosaccharides of vesicular stomatitis and influenza virus envelope glycoproteins: host cell specificity, subcellular localization and identification of substituted saccharides." Biochemical Journal 329, no. 3 (1998): 511–18. http://dx.doi.org/10.1042/bj3290511.

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The presence of sulphate groups on various saccharide residues of N-linked carbohydrate units has now been observed in a number of glycoproteins. To explore the cell specificity of this post-translational modification, we evaluated sulphate incorporation into virus envelope glycoproteins by a variety of cells, since it is believed that assembly of their N-linked oligosaccharides is to a large extent dependent on the enzymic machinery of the host. Employing the vesicular stomatitis virus (VSV) envelope glycoprotein (G protein) as a model, we noted that the addition of [35S]sulphate substituents

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COUTO, A., M. GONCALVES, W. COLLI та R. DELEDERKREMER. "The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl (α1–3)galactose units". Molecular and Biochemical Parasitology 39, № 1 (1990): 101–7. http://dx.doi.org/10.1016/0166-6851(90)90012-b.

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27

Avila, Jose Luis, Gladys Velazquez-Avila та Miguel Rojas. "Characterization of a Natural Human Antibody with Anti-Galactosyl(α1-2)galactose Specificity that is Present at High Titers in Chronic Trypanosoma Cruzi Infection". American Journal of Tropical Medicine and Hygiene 47, № 4 (1992): 413–21. http://dx.doi.org/10.4269/ajtmh.1992.47.413.

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28

Perez-Aguilar, Sandra, David Torres-Tirado, Guadalupe Martell-Gallegos, et al. "G protein-coupled receptors mediate coronary flow- and agonist-induced responses via lectin-oligosaccharide interactions." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 5 (2014): H699—H708. http://dx.doi.org/10.1152/ajpheart.00481.2013.

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Blood flow acts parallel to the coronary luminal endothelial surface layer (LESL) and modulates multiple parenchymal functions via the release of paracrine agents. Evidence indicates that the LESL may be a flow-sensing organelle and that perhaps through flow-induced lectin (L)·oligosaccharide (O) complex formation (L·O) participates in this process. LESL integrins and selectins are both lectinic and flow sensitive, but the L properties of flow-sensitive G protein-coupled receptors (GPCRs) are unknown. Therefore, we investigated the presence of L in the LESL and hypothesized that if flow-sensit

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Jantscher-Krenn, Evelyn, Tineke Lauwaet, Laura A. Bliss, Sharon L. Reed, Frances D. Gillin, and Lars Bode. "Human milk oligosaccharides reduceEntamoeba histolyticaattachment and cytotoxicityin vitro." British Journal of Nutrition 108, no. 10 (2012): 1839–46. http://dx.doi.org/10.1017/s0007114511007392.

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Human milk oligosaccharides (HMO), complex sugars that are highly abundant in breast milk, block viral and bacterial attachment to the infant's intestinal epithelium and lower the risk of infections. We hypothesised that HMO also prevent infections with the protozoan parasiteEntamoeba histolytica,as its major virulence factor is a lectin that facilitates parasite attachment and cytotoxicity and binds galactose (Gal) andN-acetyl-galactosamine. HMO contain Gal, are only minimally digested in the small intestine and reach the colon, the site ofE. histolyticainfection. The objective of the present

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Capul, Althea A., Suzanne Hickerson, Tamara Barron, Salvatore J. Turco, and Stephen M. Beverley. "Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major." Infection and Immunity 75, no. 9 (2007): 4629–37. http://dx.doi.org/10.1128/iai.00735-07.

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ABSTRACT Abundant surface Leishmania phosphoglycans (PGs) containing [Gal(β1,4)Man(α1-PO4)]-derived repeating units are important at several points in the infectious cycle of this protozoan parasite. PG synthesis requires transport of activated nucleotide-sugar precursors from the cytoplasm to the Golgi apparatus. Correspondingly, null mutants of the L. major GDP-mannose transporter LPG2 lack PGs and are severely compromised in macrophage survival and induction of acute pathology in susceptible mice, yet they are able to persist indefinitely and induce protective immunity. However, lpg2 − L. m

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ROBBE, Catherine, Calliope CAPON, Bernadette CODDEVILLE, and Jean-Claude MICHALSKI. "Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract." Biochemical Journal 384, no. 2 (2004): 307–16. http://dx.doi.org/10.1042/bj20040605.

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Purified human mucins from different parts of the intestinal tract (ileum, cecum, transverse and sigmoid colon and rectum) were isolated from two individuals with blood group ALeb (A-Lewisb). After alkaline borohydride treatment the released oligosaccharides were structurally characterized by nano-ESI Q-TOF MS/MS (electrospray ionization quadrupole time-of-flight tandem MS) without prior fractionation or derivatization. More than 100 different oligosaccharides, with up to ten monosaccharide residues, were identified using this technique. Oligosaccharides based on core 3 structures, GlcNAc(β1-3

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Rawley, Orla, Jamie O'Sullivan, Gudmundur Bergsson, et al. "Specific N- and O-Linked Carbohydrate Structures Mediate Von Willebrand Factor Interaction with Galectins -1 and -3." Blood 118, no. 21 (2011): 2234. http://dx.doi.org/10.1182/blood.v118.21.2234.2234.

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Abstract Abstract 2234 Von Willebrand Factor (VWF) is extensively glycosylated with both N- and O-linked carbohydrates. Moreover, these complex glycan structures influence VWF functional properties, including susceptibility to ADAMTS13 proteolysis, and plasma clearance. The molecular mechanisms through which VWF glycosylation (including ABO blood group antigens) act to influence VWF physiology remains unexplained. However, recent data suggest that VWF circulates in normal plasma bound to various carbohydrate-binding proteins, including specific members of the galectin family. In addition, gale

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Zinger-Yosovich, Keren, Dvora Sudakevitz, Anne Imberty, Nachman C. Garber, and Nechama Gilboa-Garber. "Production and properties of the native Chromobacterium violaceum fucose-binding lectin (CV-IIL) compared to homologous lectins of Pseudomonas aeruginosa (PA-IIL) and Ralstonia solanacearum (RS-IIL)." Microbiology 152, no. 2 (2006): 457–63. http://dx.doi.org/10.1099/mic.0.28500-0.

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Chromobacterium violaceum is a versatile, violet pigment (violacein)-producing β-proteobacterium, confined to tropical and subtropical regions, dwelling in soil and water, like Pseudomonas aeruginosa and Ralstonia solanacearum. These three bacteria are saprophytes that occasionally become aggressive opportunistic pathogens virulently attacking animals (the first two) and plants (the third). The recent availability of their genome sequences enabled identification in the C. violaceum genome of an ORF (locus no. 1744) that is similar to those of P. aeruginosa and R. solanacearum lectins, PA-IIL a

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Sullivan, Jamie O', Orla Rawley, Vince Jenkins, Alain Chion, Teresa M. Brophy, and James S. O'Donnell. "Identification Of Galectin-1 and Galectin-3 As Novel Binding Partners For Factor VIII." Blood 122, no. 21 (2013): 28. http://dx.doi.org/10.1182/blood.v122.21.28.28.

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Abstract During biosynthesis, Factor VIII (FVIII) undergoes complex post-translational modification including significant glycosylation. Consequently each FVIII molecule can contains 25 N- and 6 O-linked glycans. These carbohydrate structures are of physiological significance. For example, FVIII glycan expression modulates intracellular trafficking and also regulates FVIII clearance by dendritic cells. Nevertheless, the molecular mechanisms through which glycan structures influence FVIII biology remains poorly defined. Interestingly, carbohydrate-binding galectins (Gal) -1 and -3 have recently

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Geiger, T., Y. Lamri, T. A. Tran-Thi та ін. "Biosynthesis and regulation of rat α1-inhibitor3, a negative acute-phase reactant of the macroglobulin family". Biochemical Journal 245, № 2 (1987): 493–500. http://dx.doi.org/10.1042/bj2450493.

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The biosynthesis of rat alpha 1-inhibitor3, a negative acute-phase reactant specifically found in rodents, was studied in vitro in a cell-free translation system from rabbit reticulocytes, in rat hepatocyte primary cultures and in vivo by immunocytochemistry using normal and turpentine-injected rats. By sucrose-gradient centrifugation and subsequent translation of the fractionated RNA in vitro it was found that the mRNA coding for alpha 1-inhibitor3 exhibited a size of about 28S. For the alpha 1-inhibitor3 translated in vitro an apparent Mr of 155,000 was determined. A continuous decrease in t

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Scanlan, Christopher N., Ralph Pantophlet, Mark R. Wormald та ін. "The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120". Journal of Virology 76, № 14 (2002): 7306–21. http://dx.doi.org/10.1128/jvi.76.14.7306-7321.2002.

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ABSTRACT 2G12 is a broadly neutralizing human monoclonal antibody against human immunodeficiency virus type-1 (HIV-1) that has previously been shown to bind to a carbohydrate-dependent epitope on gp120. Here, site-directed mutagenesis and carbohydrate analysis were used to define further the 2G12 epitope. Extensive alanine scanning mutagenesis showed that elimination of the N-linked carbohydrate attachment sequences associated with residues N295, N332, N339, N386, and N392 by N→A substitution produced significant decreases in 2G12 binding affinity to gp120JR-CSF. Further mutagenesis suggested

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Shrestha, BM. "Xenotransplantation for Renal Failure Patients: Evolution of Strategies." December 23, 2016. https://doi.org/10.19070/2328-3548-1600010e.

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Although renal transplantation (RT) has improved quality of life and survival, organ shortage has led to expansion of waiting list and premature deaths. Over 100000 patients in the United States, similar number worldwide and over 7000 patients in the United Kingdom are waiting for RT. This has encouraged scientists to explore animals, xenotransplantation, as an alternative source of unlimited organ supply over the past three decades to overcome the chronic shortage of deceased and living human donors [1]. Successful xenotransplantation would eliminate the effects of brain death, ischaemia-repe

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Ramasamy, Ranjan. "Mosquito vector proteins homologous to α1-3 galactosyl transferases of tick vectors in the context of protective immunity against malaria and hypersensitivity to vector bites". Parasites & Vectors 14, № 1 (2021). http://dx.doi.org/10.1186/s13071-021-04801-7.

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Abstract Background An epitope, Galα1-3Galβ1-4GlcNAc-R, termed α-gal, is present in glycoconjugates of New World monkeys (platyrrhines) and other mammals but not in hominoids and Old World monkeys (catarrhines). The difference is due to the inactivation of α1-3 galactosyl transferase (α1-3 GT) genes in catarrhines. Natural antibodies to α-gal are therefore developed in catarrhines but not platyrrhines and other mammals. Hypersensitivity reactions are commonly elicited by mosquito and tick vector bites. IgE antibodies against α-gal cause food allergy to red meat in persons who have been exposed

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Chen, Qiushi, Han Liu, and Xuechen Li. "Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins." Exploration of Drug Science, February 28, 2023, 31–54. http://dx.doi.org/10.37349/eds.2023.00004.

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It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface. It presents as a terminal structure on either glycoproteins or glycolipids and has been demonstrated to be related to various biological processes, such as fertilization and selectin binding. Due to the vital role of sLeX, its synthesis as well as its determination approaches have attracted considerable attention from many researchers. In this review, the focus

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Kawakita, Chieko, Koki Mise, Yasuhiro Onishi, et al. "Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-77736-1.

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AbstractIn IgA nephropathy (IgAN), IgA1 molecules are characterized by galactose deficiency in O-glycans. Here, we investigated the association between urinary glycosylation profile measured by 45 lectins at baseline and renal prognosis in 142 patients with IgAN. The primary outcome was estimated glomerular filtration rate (eGFR) decline (> 4 mL/min/1.73 m2/year), or eGFR ≥ 30% decline from baseline, or initiation of renal replacement therapies within 3 years. During follow-up (3.4 years, median), 26 patients reached the renal outcome (Group P), while 116 patients were with good renal outco

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Salama, Apolline, Mathilde Mosser, Xavier Lévêque та ін. "Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs". 13 січня 2017. https://doi.org/10.2337/db16-1060.

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Xenocell therapy from neonate or adult pig pancreatic islets is one of the most promising alternatives to allograft in type 1 diabetes for addressing organ shortage. In humans, however, natural and elicited antibodies specific for pig xenoantigens, α-(1,3)-galactose (GAL) and N-glycolylneuraminic acid (Neu5Gc), are likely to significantly contribute to xenoislet rejection. We obtained double-knockout (DKO) pigs lacking GAL and Neu5Gc. Because Neu5Gc−/− mice exhibit glycemic dysregulations and pancreatic β-cell dysfunctions, we evaluated islet function and glucose metabolism regulation in DKO p

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Yang, Jia‐He, Jun Gao, Ya‐Qi E та ін. "Hydrogen sulfide inhibits skeletal muscle ageing by up‐regulating autophagy through promoting deubiquitination of adenosine 5’‐monophosphate (AMP)‐activated protein kinase α1 via ubiquitin specific peptidase 5". Journal of Cachexia, Sarcopenia and Muscle, 27 серпня 2024. http://dx.doi.org/10.1002/jcsm.13560.

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AbstractBackgroundHydrogen sulfide (H2S), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether H2S alleviates skeletal muscle ageing by regulating autophagy has not been reported.MethodsMice were administered 150 mg/kg/day of D‐galactose ( D‐gal), and C2C12 myotubes were cultured in 20 g/L D‐gal to induce ageing. Sodium hydrosulfide (NaHS) was employed as an exogenous donor in the treatment group. The intracellular concentration of H2S was quantified by the 7‐azido‐4‐methylcoumarin fluorescence probe. The proteins involved in the ubiquitin‐mediated degr

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