Relevant bibliographies by topics / Gamma-secretase modulators

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Gamma-secretase modulators'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Gamma-secretase modulators"

1

Rotella, David P. "Gamma Secretase Modulators." ACS Medicinal Chemistry Letters 4, no. 9 (2013): 823. http://dx.doi.org/10.1021/ml4002826.

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Velter, Adriana I., François P. Bischoff, Didier Berthelot, et al. "Anilinotriazoles as potent gamma secretase modulators." Bioorganic & Medicinal Chemistry Letters 24, no. 24 (2014): 5805–13. http://dx.doi.org/10.1016/j.bmcl.2014.10.024.

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Kukar, Thomas L., Thomas B. Ladd, Maralyssa A. Bann, et al. "P2-338: Substrate-targeting gamma-secretase modulators." Alzheimer's & Dementia 4 (July 2008): T472. http://dx.doi.org/10.1016/j.jalz.2008.05.1415.

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Tate, Barbara, Timothy D. McKee, Robyn M. B. Loureiro, et al. "Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease." International Journal of Alzheimer's Disease 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/210756.

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The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβpeptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-Takahara et al., 2005). Sinceγ-secretase is critical for Aβproduction, many in the biopharmaceutical community focused onγ-secretase as a target for therapeutic approaches for Alzheimer's disease. However, pharmacological approaches to controlγ-secretase activity are challenging because the enzyme has mul
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Mekala, Shekar, Grady Nelson та Yue-Ming Li. "Recent developments of small molecule γ-secretase modulators for Alzheimer's disease". RSC Medicinal Chemistry 11, № 9 (2020): 1003–22. http://dx.doi.org/10.1039/d0md00196a.

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Shi, Jianliang, Dmitry Zuev, Li Xu, et al. "Design and optimization of tricyclic gamma-secretase modulators." Bioorganic & Medicinal Chemistry Letters 26, no. 5 (2016): 1498–502. http://dx.doi.org/10.1016/j.bmcl.2015.06.020.

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Bursavich, Matthew G., Bryce A. Harrison, and Jean-François Blain. "Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?" Journal of Medicinal Chemistry 59, no. 16 (2016): 7389–409. http://dx.doi.org/10.1021/acs.jmedchem.5b01960.

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Felsenstein, Kevin, Joo-In Jung, Thomas Ladd, et al. "S1-01-04: Cholesterol metabolites as endogenous gamma-secretase modulators." Alzheimer's & Dementia 9 (July 2013): P121—P122. http://dx.doi.org/10.1016/j.jalz.2013.04.035.

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Rynearson, Kevin D., Ronald N. Buckle, R. Jason Herr, et al. "Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators." Bioorganic & Medicinal Chemistry 28, no. 22 (2020): 115734. http://dx.doi.org/10.1016/j.bmc.2020.115734.

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Rynearson, Kevin D., Ronald N. Buckle, Keith D. Barnes, et al. "Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme." Bioorganic & Medicinal Chemistry Letters 26, no. 16 (2016): 3928–37. http://dx.doi.org/10.1016/j.bmcl.2016.07.011.

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Dissertations / Theses on the topic "Gamma-secretase modulators"

1

Itkin, Anna. "Multidisniplinary study of Alzheimer's disease-related peptides : from amyloid precursor protein (APP) to amyloid β-oligomers and γ-secretase modulators". Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAF051/document.

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Une des caractéristiques histopathologiques de la maladie d'Alzheimer (AD) est la présence de plaques amyloïdes formées par les peptides amyloïdes β (Aβ) de 40 et 42 résidus, qui sont les produits de clivage par des protéases de l'APP. Afin de comprendre le rôle des variations structurelles du TM dans le traitement de l'APP, les peptides APP_TM4K ont été étudiés dans la bicouche lipidique en utilisant l’ATR-FTIR et ssNMR. Tandis que la structure secondaire globale du peptide APP_TM4K est hélicoidale, hétérogénéité de conformation et d'orientation a été observée pour le site de clivage γ et ,
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Czirr, Eva [Verfasser]. "γ-secretase [gamma-secretase] modulators and inhibitors in Alzheimer's disease : influence of genetic background on efficacy and mechanism of action / Eva Czirr". 2008. http://d-nb.info/990736806/34.

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Kodam, Anitha. "Cellular level/distribution of -secretase subunit nicastrin and its modulator p23 in the brain." Master's thesis, 2010. http://hdl.handle.net/10048/955.

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The processing of amyloid precursor protein (APP) by - and -secretases produces amyloid (A) peptide, the principal component of the neuritic plaques found in Alzheimers disease (AD) pathology. The enzyme -secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin, anterior pharynx defective 1 (APH-1) and presenilin enhancer-2 (PEN-2). Recently it was discovered that p23, a transmembrane protein involved in intracellular protein trafficking, negatively regulates -secretase activity. In the present study, I evaluated the levels/expression of the nicastrin and p23 and t
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Book chapters on the topic "Gamma-secretase modulators"

1

Rynearson, Kevin D., Rudolph E. Tanzi, and Steven L. Wagner. "Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease." In Translational Neuroscience. Springer US, 2016. http://dx.doi.org/10.1007/978-1-4899-7654-3_19.

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Shen, Ruichao, Nathan O. Fuller, Jed L. Hubbs, Wesley F. Austin, and Brian S. Bronk. "Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease." In Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1. American Chemical Society, 2016. http://dx.doi.org/10.1021/bk-2016-1239.ch011.

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Hubbs, Jed L., Nathan O. Fuller, Wesley F. Austin, Ruichao Shen, and Brian S. Bronk. "Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease: Part I." In Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1. American Chemical Society, 2016. http://dx.doi.org/10.1021/bk-2016-1239.ch010.

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You might also be interested in the extended bibliographies on the topic 'Gamma-secretase modulators' for particular source types:
Journal articles
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