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1

GJERTZ, EMIL, and SVKN HELLERSTRÖM. "Tumeur du ganglion de Gasser." Acta Medica Scandinavica 63, no. 1 (April 24, 2009): 7–23. http://dx.doi.org/10.1111/j.0954-6820.1925.tb15342.x.

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2

Lamoureux, M., P. Bonnot, A. R. Schmidt-Guerre, P. Humbert, M. P. Algros, and C. Meyer. "Ulcération neurotrophique après thermocoagulation du ganglion de Gasser." Revue de Stomatologie et de Chirurgie Maxillo-faciale 112, no. 6 (December 2011): 372–78. http://dx.doi.org/10.1016/j.stomax.2011.01.012.

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3

Sonig, Ashish, Jai Thakur, Monica Grass, Imad Saeed Khan, Viraj Gandhi, and Anil Nanda. "Antonius Balthazar Raymundus Hirsch and the peregrination of “gasserian ganglion”." Journal of Neurosurgery 119, no. 3 (September 2013): 778–84. http://dx.doi.org/10.3171/2013.4.jns121340.

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The anatomical description of the fifth cranial nerve ganglion lacked detail before the work of Antonius Balthazar Raymundus Hirsch (1744–1778). Hirsch used new dissection techniques that resulted in the most meticulous report of the trigeminal ganglion (the gasserian ganglion) to have been reported. In 1765, the 21-year-old published these findings in a thesis, Paris Quinti Nervorum Encephali Disquisitio Anatomica In Quantum Ad Ganglion Sibi Proprium, Semilunare, Et Ad Originem Nervi Intercostalis Pertinet [An anatomical inquiry of the fifth pair of the nerves of the brain, so far as it relates to the ganglion unto itself, the semilunar, and to the source of the intercostal nerve]. Hirsch wrote his thesis as a paean to his ailing teacher, Johann Lorenz Gasser, but Gasser died before Hirsch was able to defend his thesis. Thereafter, Hirsch applied to teach anatomy at his alma mater, the University of Vienna, but the university did not consider his application, deeming him too young for the position. Oddly, Hirsch died at the young age of 35. For the present paper, the library at the University of Vienna (Universität Wien), Austria, was contacted, and Anton Hirsch's thesis was digitized and subsequently translated from Latin into English. The authors here attempt to place the recognition of the fifth cranial nerve ganglion within a historical perspective and trace the trajectory of its anatomical descriptions.
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4

Zulueta, L., J. Piedra, L. Ochoa, and G. Lopez. "5-46-12 Blood pressure changes during gasser ganglion microcompression on the trigeminal neuralgia." Journal of the Neurological Sciences 150 (September 1997): S336. http://dx.doi.org/10.1016/s0022-510x(97)86547-1.

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5

Longeac, M., M. Lapeyre, C. Delbet Dupas, I. Barthélémy, and N. Pham Dang. "Radiothérapie exclusive d’un carcinome basocellulaire de la face avec atteinte du ganglion de Gasser." Cancer/Radiothérapie 20, no. 4 (June 2016): 308–11. http://dx.doi.org/10.1016/j.canrad.2015.12.006.

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6

Sindou, M., and M. Tatli. "Traitement de la névralgie trigéminale par injection de glycérol au niveau du ganglion de Gasser." Neurochirurgie 55, no. 2 (April 2009): 211–12. http://dx.doi.org/10.1016/j.neuchi.2009.01.009.

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7

Litré, C. F., C. Eap, P. Peruzzi, J. Duntze, A. Bazin, and P. Rousseaux. "Place des techniques percutanées de microcompression du ganglion de Gasser dans la névralgie trijéminale au xxie siècle. Expérience rémoise." Neurochirurgie 55, no. 4-5 (October 2009): 510. http://dx.doi.org/10.1016/j.neuchi.2009.08.089.

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8

Tikhonovich, O. G., O. A. Azev, N. V. Yakubovich, and V. A. Kul’chitskii. "Dependence of electrical activity of neurons in rostral parts of spinal trigeminal nucleus on functional state of trigeminal Gasser ganglion." Bulletin of Experimental Biology and Medicine 144, no. 1 (July 2007): 1–3. http://dx.doi.org/10.1007/s10517-007-0238-0.

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9

Hufschmidt, K., J. Fernandez, T. Balaguer, D. Fontaine, and B. Chignon-Sicard. "Traitement de l’ulcération neurotrophique après alcoolisation du ganglion de Gasser dans l’atteinte du nerf trijumeau : cas clinique et revue de la littérature." Annales de Chirurgie Plastique Esthétique 62, no. 1 (February 2017): 79–86. http://dx.doi.org/10.1016/j.anplas.2016.03.004.

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10

Pérez-Cajaraville, J., M. Aseguinolaza Pagola, P. Molina Tresaco, J. Arranz Duran, and D. Abejon Gonzalez. "Neuralgia del trigémino: radiofrecuencia ganglio de Gasser." Revista de la Sociedad Española del Dolor 20, no. 2 (April 2013): 89–100. http://dx.doi.org/10.4321/s1134-80462013000200007.

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11

Slavik, Eugen, S. Ivanovic, M. Spaic, and B. Djurovic. "Idopathic tigeminal neuralgia: Radiophrequency rhizotomy of ganglion Gasseri." Acta chirurgica Iugoslavica 51, no. 4 (2004): 31–38. http://dx.doi.org/10.2298/aci0404031s.

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Idiopathic trigeminal neuralgia (ITN), ( tic douloureux), may be defined as a chronic painfull disorder of the sensory divisions of the trigeminal nerve, with unexplained cause and pathogenesis. The clinical features are characterized by recurrent paroxysmal lancinating pain confined to distribution of one or more branches of the nerve. Radio frequency rhizotomy (RFR) of ganglion Gasseri is a method of choice in treatment of ITN. We present the series of 1600 patients suffering from ITN who underwent RFR between 1984 and 2001. Ages ranged from 29 to 88 years, with a mean age of 62 years. Total pain relief immediately after a single radio frequency lesion was achieved in 1469 (92%) of patients. After one year a recurrence of pain was present in 145 (10%). Age, sex and duration of illness were unrelated to outcome. Patients previously treated by open surgery appeared to receive less benefit from subsequent RFR. Clinical outcome correlated with the degree of sensory deficit created by RFR. Patients acquiring dense deficit demonstrated a reduced risk of recurrence: 203/1129 (18%) of patients with dense sensory loss and 75/258 (29%) of those with a partial deficit developed a recurrence by three years, whereas almost all patients (78/82) without initial sensory loss suffered a recurrence by three years. Serious complications resulting from RFR were infrequent and the most common was the permanent dysesthesia in 9 (0,6%) of patients. Our results suggest that the RFR is an well bearable and effective long term surgical treatment for ITN, especially for older and poor-risk patients.
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12

Carella, A., C. F. Andreula, and G. Marano. "Patologia del nervo trigemino." Rivista di Neuroradiologia 5, no. 2 (May 1992): 223–35. http://dx.doi.org/10.1177/197140099200500211.

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Scopo del nostro studio è stato quello di fornire una mappa quanto più possibile dettagliata del nervo trigemino, del suo decorso e della sua patologia. Nel percorso abbiamo preferito utilizzare come riferimento l'anatomia patologica topografica, diffidando dai singoli aspetti clinici, spesso contraddittori e non corrispondenti alla neuropatologia. Il nervo è stato suddiviso in quattro segmenti anatomici: porzione tronco-encefalica (comprendente nuclei e vie di proiezione), radice pregangliare, ganglio di Gasser e terminazioni periferiche (sensitive e motorie). Per ognuno di questi segmenti sono stati esaminati gli aspetti patologici su base vascolare (comprendente lesioni ischemiche, emorragiche, malformative ed il cosiddetto ‘conflitto neurovascolare»), infiammatoria (sclerosi multipla), malformativa e neoplastica. Secondo dati statistici più frequente è l'interessamento delle terminazioni periferiche, seguite dal segmento intracisternale, dai nuclei del tronco encefalico e dal ganglio di Gasser. Metodica neuroradiologica di scelta si è rivelata essere la risonanza magnetica in virtù del suo maggiore potere di risoluzione in alcuni distretti anatomici rispetto ad altre tecniche digitalizzate, della capacità di fornire immagini multiplanari e della maggiore sensibilità e specificità.
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13

Bárcena Orbe, A., J. Rodríguez Hernández, C. Mestre Moreiro, J. M. Cañizal García, B. Rivero Martín, F. Esteban Alonso, V. Vanaclocha Vanaclocha, and J. Luis Zubieta. "Fístula arteriovenosa extracraneal secundaria a microcompresión percutánea del ganglio de Gasser." Neurocirugía 5, no. 3 (1994): 259–61. http://dx.doi.org/10.1016/s1130-1473(94)71114-3.

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14

Panning, B., and H. Wiegand. "Anästhesiologische Probleme und Komplikationen bei der Thermokoagulation des Ganglion Gasseri*." min - Minimally Invasive Neurosurgery 28, no. 02 (March 1985): 61–63. http://dx.doi.org/10.1055/s-2008-1054185.

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15

Rivera Díaz, Roberto Carlo, José Libardo Bastidas Benavides, and Juliana García Álvarez. "Radiofrecuencia térmica del ganglio de Gasser en pacientes con neuralgia del trigémino." Revista Colombiana de Anestesiología 41, no. 2 (April 2013): 127–31. http://dx.doi.org/10.1016/j.rca.2013.03.001.

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16

Waidhauser, E., and U. Steude. "Evaluation of Patients with Atypical Trigeminal Neuralgia for Permanent Electrode Implant by Test Stimulation of the Ganglion gasseri." Stereotactic and Functional Neurosurgery 62, no. 1-4 (1994): 304–8. http://dx.doi.org/10.1159/000098637.

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17

Encinas, E. "Contribución a la clínica e histopatología de la endarteritis sifilítica de los pequeños vasos de la corteza." Anales de la Facultad de Medicina 26, no. 3 (October 18, 2014): 325. http://dx.doi.org/10.15381/anales.v26i3.9664.

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Se estudia las alteraciones histológicas del cerebro y de los órganos extracerebrales de una enferma que permaneció treinta años en el hospital psiquiátrico de Magdalena del Mar con el diagnóstico de psicosis maniaca, diagnóstico que fué a su ingreso de demencia precoz. El examen muestra que el cambio dominante en el cerebro es la endarteritis de los pequeños vasos de la corteza, tipo endarteritis sifilítica, entidad estudiada por primera vez por NISSL y ALZHEIMER en 1903. Han sido comprobadas alteraciones en los vasos, pía, elementos ganglionares y glióticos, del cerebro, y modificaciones estructurales en los órganos extracerebrales. En la pía dominan los cambios de carácter crónico y agudo. Al primero corresponden viejas alteraciones meningeas en concomitancia, corrientemente, con esclerosis vasculares; al segundo, los infiltrados perivasculares de células de inflamación en los que es frecuente hallar elementos densos de contorno anguloso, con escasa o ninguna evidencia de cuerpo nuclear, de franca cepa conectiva, y muy frecuente también en los infiltrados de otros órganos, del hígado por ejemplo. Carácter dominante de la lesión típica vascular es la proliferación adventicial y endotelial. No es raro encontrar sobre todo en los vasos de calibre mayor, alteraciones degenerativas de la capa media, de carácter hialino o escleroso. En vasos de mayor dimensión es frecuente la presencia de lesiones proliferativas y degenerativas de la íntima. Las mismas lesiones vasculares se hallan en órganos extracerebrales como el útero, cápsulas suprarrenales, hígado, etc. Lesiones de carácter escleroso han sido comprobados en el útero; concreciones y totales oclusiones cálcicas en los vasos del ganglio de Gasser y los plexos coroides; degeneraciones hialinas en la capa media de los vasos medianos en el cerebro, cápsulas suprarrenales, ovario y útero; y, puentes endoteliales en el ovario, todo lo que acusa que el cambio vascular ha tenido carácter general. Hay dos clases de alteraciones ganglionares : unas dependientes de las lesiones de los vasos y en inmediata relación con éstos, las necrosis y alteraciones individuales celulares perivasculares; otras, independientes y muy alejados de los mismos: los cambios sistemáticos. El compromiso exclusivo de las células de la III~ lámina de la corteza (Figs. Nos. 14 y 15), pertenece a esta categoría, lo mismo que la desaparición de las células de Purkinje y las alteraciones necróticas del nucleus dentatus del cerebelo. Territorios que poseen una vulnerabilidad general han sido intensamente comprometidos, como el asta de Ammon. No sólo, aisladamente sus elementos constitutivos, sino su arquitectura muestran considerables cambios: Fig. No. 50. Hay evidente necrosis de grupos celulares de la médula espinal, principalmente del n. proprius cornu anterioris y del n. myorabdoticus lateralis, muchos de cuyos elementos, sobre todo del primero, han desaparecido. Interesante es que estos cambios no han guardado relación con manifestaciones clínicas correspondientes. En ningún momento por lo menos hasta pocos días antes de su muerte, presentó la enferma síntomas cerebelosos o medulares. Además en el cerebelo hay alteraciones de las fibras del canastillo, lo que le da un cierto parecido con la heredo-ataxia cerebelosa, de cuyas modificaciones cerebelosos se aparta por conservarse indemne la capa granulosa. Las alteraciones cerebelosas no son propias de la enfermedad. Es sabido que la sífilis en sus diferentes formas compromete extensos territorios del órgano, a veces lóbulos íntegros. Mediante el empleo de los procedimientos argénticos de DEL RIO HORTEGA se ha logrado hacer visibles tanto en los más apartados territorios de la corteza, como en el bulbo y otras formaciones nerviosas, las más diversas e interesantes formaciones glióticas de tipo astrocitario, sobre todo, en la periferie de los capilares donde se ha desarrollado con particular intensidad los típicos anillos glióticos perivasculares. Además redes de glía de las más variadas tramas, y elementos de esta especie de la mayor diversidad, han sido hallados en distintos territorios del sistema nervioso. El examen histológico confirma la suposición hace mucho tiempo sostenida de ser heterogénea la arquitectura gliótica de la corteza, y, como consecuencia distinta su manera reaccional frente a los agentes alterantes. Convendría estudiar este punto en lo normal y en lo patológico. Al contrario de lo que ocurre en la parálisis general o en procesos sifilíticos de curso agudo, la reacción microglial ha sido casi nula. El astrocito ha sido el elemento dominante, cambio que parece aparejarse con el carácter crónico de la enfermedad. Se ha comprobado en el bulbo: cuerpos amiláceos en las vecindades de la superficie del 4º ventrículo y particulares estados degenerativos de los elementos ganglionares de los núcleos : magno cellularis funiculi posterioris, sustancia reticularís grisea, n. ambiguos, y n. arcuatus. Además nódulos glióticos neuronofágicos. En los ventrículos internos se ha desarrollado una ependimitis proliferativa y exudativa, en muchos sitios ha sido rota la barrera ependimaria, y elementos glióticos subependimarios han hecho su irrupción en la cavidad interna mezclándose con los componentes morfológicos del exudado. Por último en algunos lugares ha sido destruida la barrera ependimaria. Semejantes alteraciones han sido descritas en diversas clases de sífilis. Se ha estudiado diversos órganos extracerebrales con el propósito de averiguar su repercusión en el proceso. Gran parte de los vasos presentan las mismas alteraciones que los del cerebro, esto es las proliferaciones endo y adventiciales, pero aparte de éstas es frecuente hallar cambios degenerativos de la capa media de los de mediano calibre. Junto con tales alteraciones y como su consecuencia, necrosis y degeneraciones de la más variada índole se han hecho presentes en diversos órganos, como las insulares del parénquima hepático y del bazo, las de las células y fibras del ganglio de Gasser, dependientes estas últimas como se ve en las fotografías respectivas, de procesos calcificantes oclusivos de los capilares. Se estudia en el hígado las fases de una proliferación conectiva peribiliar, con tendencia oclusiva por estrechamiento de la luz canalicular; y la particular reacción de las células de Kupffer. Fig. No. 64. Eh la hipófisis se comprueba un desarrollo considerable del componente fibroso que "ahoga" islotes glandulares. CIÍnicamente el curso de la enfermedad fué crónico; sus síntomas los d~ una psicosis maniaca; la causa inmediata de la muerte una cardiopatía rápidamente descompensada; lo más notable en el aspecto psíquico la contribución presentada por la enferma al enriquecimiento del folk-lore nacional por la suma de cantares, consejas y refranes que su memoria había por felicidad conservado.
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18

Rivera, Guillermo. "Trigeminal nerve: essential aspects from the biomedical sciences." Revista Estomatología 19, no. 2 (September 28, 2017). http://dx.doi.org/10.25100/re.v19i2.5732.

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he trigeminal nerve or V cranial pair of 12 cranial pairs identified since 1798, is the nerve of the first pharyngeal arch and provides general somaticc sensitivity of many structures of the head, except to the scalp below vertex. It is the most voluminous nerve of all cranial pairs of the encephalic peripheral nervous system. It has its apparent origin in the anterior and lateral region near the middle cerebellar peduncle and its true origins distributed in pseudounipolar neurons of trigeminal ganglion “Gasser” located in the middle cranial fossa and sensory and motor nuclei located at different levels of brain stem. Of the three peripheral divisions of the trigeminal nerve, maxillary and mandibular divisions provide the sensory innervation of the structures that constitute the oral cavity, and mandibular division also suppliesmotor innervation of the masticatory muscles, making it an essential anatomical reference for dentistry. Key words: Trigeminal nerve, ophthalmic nerve, maxillary nerve, mandibular nerve, gasserian ganglion, dermatome.
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19

Taheri, Arman, and Shahram Sepehrmand. "Is trigeminal neuralgia the only definitive diagnosis for pain in a tooth extraction site?" BMC Oral Health 21, no. 1 (June 7, 2021). http://dx.doi.org/10.1186/s12903-021-01645-6.

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AbstractKnowing the International Classification of Orofacial Pain helps pain specialists to differentiate types of orofacial pain. It is important to select the best treatment or intervention for the patients based on the diagnosis. As part of our study, we reviewed the article published in BMC Oral Health, titled “Clinical characteristics and associated factors of trigeminal neuralgia: Experience from Addis Ababa, Ethiopia” by Ayele et al. (Ethiopia BMC Oral Health 20(1):7, 2020). For patients suffering from Classical Trigeminal Neuralgia taking a suitable dose of Carbamazepine or Gasser Ganglion radiofrequency could be helpful. Patients complaining Trigeminal neuralgia who had a history of a dental extraction in the painful region should be categorized in other group as Complex Regional Pain Syndrome type 1, who need larger dose of carbamazepine with anticonvulsant or tricyclic agent drugs (e.g. pregabalin or doxepin) or intervention (PPG radiofrequency).
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20

Bale, R., A. Schlager, I. Laimer, R. Jakober, T. Lang, C. Hinterleither, M. Knoflach, and W. Jaschke. "Computerunterstützte Radiofrequenzablation des Ganglion Gasseri bei Patienten mit Trigeminusneuralgie." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 177, S 01 (April 20, 2005). http://dx.doi.org/10.1055/s-2005-868282.

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21

Mehrkens, J., A. Leunig, G. Rasp, and U. Steude. "Elektrostimulation im Ganglion Gasseri (TGES) als Therapieoption bei Trigeminusneuropathie nach (iatrogener) Läsion des Nervus Trigeminus." HNO-Informationen (Kongressabstracts) 84, no. 01 (April 26, 2005). http://dx.doi.org/10.1055/s-2005-869264.

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22

Jiménez Olvera, Miguel, Patricia Badillo Rivero, María de los Ángeles Mendiola Roa, Patricia Villanueva Garduño, Sergio De León García, José Fernando Pérez Pérez, Guadalupe Zamorano Toledano, et al. "Cambios en la presión intraocular en pacientes con neuralgia trigeminal sometidos a radiofrecuencia del ganglio de Gasser." Revista de la Sociedad Española del Dolor, 2018. http://dx.doi.org/10.20986/resed.2018.3657/2018.

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23

Keric, Naureen, Darius Kalasauskas, Sophia L. Kreth, Martin B. Glaser, Harald Krenzlin, Sven R. Kantelhardt, and Florian Ringel. "An age-dependent outcome analysis of microvascular decompression and percutaneous thermocoagulation in trigeminal neuralgia." BMC Neurology 21, no. 1 (April 29, 2021). http://dx.doi.org/10.1186/s12883-021-02197-6.

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Abstract Background Trigeminal neuralgia (TN) is a severe pain condition and the most common facial neuralgia. While microvascular decompression (MVD) presents an excellent treatment in neurovascular compression cases, percutaneous thermocoagulation (PT) of the ganglion Gasseri is an alternative option. This study aimed to evaluate post-operative complication rate and outcome of both treatment strategies related to the patient’s age. Methods The medical records of all patients with the diagnosis of trigeminal neuralgia undergoing an MVD or PT of the ganglion Gasseri (between January 2007 and September 2017) were reviewed to determine the efficacy and the complication rate of both methods in regard to the patient’s age. Results Seventy-nine patients underwent MVD surgery and 39 a PT. The mean age of patients in the MVD group was 61 years and 73 years in the PT group. There were 59 (50%) female patients. Nerve-vessel conflict could be identified in 78 (98.7%) MVD and 17 (43.6%) PT patients on preoperative MRI. Charlson comorbidity index was significantly higher in PT group (2.4 (1.8) versus 3.8 (1.8) p < 0.001). The Barrow pain score (BPS) at the last follow-up demonstrated higher scores after PT (p = 0.007). The complication rate was markedly higher in PT group, mostly due to the facial hypesthesia (84.6% versus 27.8%; p < 0.001). Mean symptom-free survival was significantly shorter in the PT group (9 vs. 26 months, p < 0.001). It remained statistically significant when stratified into age groups: (65 years and older: 9 vs. 18 months, p = 0.001). Duration of symptoms (OR 1.005, 95% CI 1.000–1.010), primary procedure (OR 6.198, 95% CI 2.650–14.496), patient age (OR 1.033, 95% CI 1.002–1.066), and postoperative complication rate (OR 2.777, 95% CI 1.309–5.890) were associated with treatment failure. Conclusion In this patient series, the MVD is confirmed to be an excellent treatment option independent of patient’s age. However, while PT is an effective procedure, time to pain recurrence is shorter, and the favorable outcome (BPS 1 and 2) rate is lower compared to MVD. Hence MVD should be the preferred treatment and PT should remain an alternative in very selected cases when latter is not possible but not in the elderly patient per se.
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24

Cánovas Martínez, Luz. "Bloqueos de las ramas periféricas del trigémino: factor predictivo de la respuesta a la radiofrecuencia pulsada del ganglio de Gasser: ¿deberíamos cambiar el protocolo?" Revista de la Sociedad Española del Dolor, 2020. http://dx.doi.org/10.20986/resed.2020.3819/2020.

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25

Oertel, Markus F., Johannes Sarnthein, Luca Regli, and Lennart H. Stieglitz. "Peroral Trigeminal Rhizotomy Using a Novel 3-Dimensional Printed Patient-Specific Guidance Tool." Operative Neurosurgery, August 30, 2021. http://dx.doi.org/10.1093/ons/opab299.

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Abstract BACKGROUND Ganglion Gasseri rhizotomy is a viable therapeutic option for trigeminal pain (TP). For this neurosurgical procedure, different potential operative and technical nuances exist. OBJECTIVE To evaluate a novel peroral trigeminal rhizotomy method and 3-dimensional printed patient-specific guidance tool (3D-PSGT) with respect to their applicability and safety. METHODS Between March 2018 and February 2021, 20 peroral balloon compression rhizotomy procedures with a 3D-PSGT were performed in 18 consecutive TP patients (13 female, mean age 58 yr). We registered the procedure duration, side effects, complications, and trigeminal function. The therapeutic effect was gauged from reduction of TP and use of analgesics. RESULTS All catheter insertions and rhizotomy procedures were successful at the first attempt. Apart from fluoroscopy, no auxiliary material was necessary. The average length of surgery was 19 min (range, 11-27 min). In total, 8 patients indicated complete analgesia and 6 patients pain relief; in 4 patients, persistence of TP was observed during follow-up examinations of up to 20 mo. In total, 6 patients reported of new mild to moderate facial hypesthesia affecting the trigeminal branches V2, V3, or V1-3. No masticatory musculature or corneal affections and device-related complications occurred. CONCLUSION The peroral 3D-PSGT trigeminal rhizotomy is straightforward for the neurosurgeon. This operative approach allows for rapid, safe, and simple foramen ovale cannulation in TP patients and reduces the use of additional equipment, radiation exposure, and procedure time.
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