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Dissertations / Theses on the topic 'Gangrena'

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Published: 4 June 2021
Last updated: 7 February 2022

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1

Calderón, Zapata Roberto. "Gangrena de Fournier en el Hospital Nacional Dos de Mayo : características clínicas y utilidad del índice de severidad de gangrena de Fournier." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/13103.

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La gangrena de Fournier es una fasceítis necrotizante con diseminación rápidamente progresiva que afecta la región perineal y genital, y el cual se asocia con un alto índice de mortalidad. Los objetivos de este estudio son analizar las características clínicas de la gangrena de Fournier y la utilidad del puntaje del Indice de Severidad de Gangrena de Fournier. Se realizó un estudio analítico y retrospectivo, en el que se incluyeron a 44 pacientes adultos diagnosticados de gangrena de Fournier en el Hospital Nacional Dos de Mayo (Lima – Perú) entre 2002 a 2012. La mayoría de pacientes fueron de sexo masculino (81.81%) y la edad promedio de presentación fue 49.72+11.055 años. Las causas más frecuentes fueron el absceso perianal (29.54%), la fistula perianal (9.09%) y traumatismos (13.62%). La principal comorbilidad asociada fue la diabetes mellitus (36,36%). Las principales características clínicas fueron fiebre, eritema perianal, dolor perianal, edema escrotal o vulvar y secreción purulenta. El principal germen aislado en los cultivos de secreciones fue la E. coli (45.45%). Hubo tendencia a la anemia y a la leucocitosis en los casos más graves. La mortalidad fue de 31.81%. El puntaje FGSI promedio en fallecidos fue 9.78+3.94 y en sobrevivientes fue 4.42+3.74. La mortalidad en pacientes con puntaje FGSI <9 fue 18.75% y en los pacientes con puntaje FGSI >9 fue de 66.66%. Entonces, el presente estudio respalda al puntaje FGSI como instrumento para valoración de severidad y para pronóstico de mortalidad.
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2

Díaz, Silva Manuel Miguel. "Gangrena de Fournier: presentación clínica, diagnóstico y tratamiento. Hospital Nacional Daniel A. Carrión 2003-2006." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2006. https://hdl.handle.net/20.500.12672/12297.

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Realiza el estudio de historias clínicas de pacientes que presentan Gangrena de Fournier, una infección necrotizante que afecta los genitales externos masculinos y el periné, causado por la sinergia de bacterias, que puede llevar a la sepsis y la consiguiente muerte. El diagnostico es clínico y con compromiso polimicrobiano. La etiología es idiopática pero existen factores predisponentes como la diabetes mellitus, insuficiencia renal, infecciones urinarias, patología colorectal, estrechez uretral, usuarios de catéteres uretrales, traumas perineales, inmunosupresión, entre otras. Las curaciones diarias y la cámara hiperbárica favorecen la granulación de las heridas y su progresiva epitelización; mientras que el uso de antibióticos, controla la infección y mejora el estado general del paciente. La falta de cultura de los pacientes hacen que lleguen tardíamente al hospital y no controlen las enfermedades que predisponen a esta patología. Por ello el autor recomienda un diagnóstico precoz y el tratamiento inmediato con un soporte hemodinámico adecuado y la limpieza quirúrgica radical para eliminar todo el tejido necrosado. A su vez, es importante la monitorización pre y post quirúrgica de las funciones vitales (función cardiaca y respiratoria) así como de los parámetros de laboratorio, para determinar los factores predisponentes y evaluar la evolución de la enfermedad.
Trabajo de investigación
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3

Castañeda, Ferradas Elsa María. "Gangrena de Fournier: epidemiología y reconstrucción. Experencia en el Servicio de Cirugía Plástica del Hospital Nacional Daniel Alcides Carrión." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2006. https://hdl.handle.net/20.500.12672/15769.

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La Gangrena de Fournier es una fasceítis necrotizante del periné y genitales de etiología infecciosa y diseminación rápidamente progresiva. El presente estudio busca identificar las características epidemiológicas, y los procedimientos reconstructivos de los pacientes con Gangrena de Fournier, hospitalizados en el Servicio de Cirugía Plástica y Reconstructiva del Hospital Nacional Daniel Alcides Carrión, de enero de 1999 a diciembre del 2005. Para ello se revisaron las historias clínicas de pacientes con diagnóstico de Gangrena de Fournier. Se halló que 11 pacientes fueron del sexo masculino (84.62 %) y 2 del sexo femenino (15.38 %). La edad media de los pacientes fue de 50.62 años (rango de 23 a 77 años). Tres pacientes (23.08 %) estaban comprendidos en el grupo etáreo de 21 a 40 años, 6 pacientes (46.15 %) en el grupo de 41 a 60 años y 4 (30.77 %) en el grupo de 61-80 años. En conclusión con el estudio, el sexo masculino predomina sobre el femenino con una relación 11:2, predomina en pacientes mayores de 40 años, con un promedio de presentación de 50.62 años y la mayoría (69.23 %) presentó factores predisponentes siendo los más frecuentes diabetes mellitus y alcoholismo (66.66 %).
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4

Uribe, Jose Azael Zambrano. "Desenvolvimento de um modelo animal para avaliação da eficiência de vacinas contra gangrena gasosa causada por Clostridium perfringens tipo A." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/SMOC-9FVPJM.

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The myonecroses infections caused by Clostridium perfringens type A are characterized by rapid course and high mortality, not knowing the impact it has on both national and global livestock. The objective of the present work was to establish a model of experimental induction of gas gangrene by inoculation of vegetative bacteria Clostridium perfringens type A, as well as to assess the efficacy of three experimental vaccines (toxoid, bacterin, toxoid + bacterin) and another of commercial source. Were used 98 albino guinea pigs (Cavia porcellus) of the lineage "Inglês short ear", males, weighing between 300 and 500 grams. Of these total, 50 were used to establish the dose of challenge and 48 for assessing the effectiveness of vaccines. For experimental reproduction of myonecrosis in guinea pigs and the production of the bacterin and toxoid were used a reference sample of the American Type Culturet colecction2 of Clostridium perfringens type A (ATCC 13124) belonging to the Anaerobic Laboratory EV -UFMG. The totality of guinea pigs (48) was divided into six groups. Were administer one ml of the immunogen subcutaneously or placebo on day zero and, at day 21 after primary vaccination, all groups were boosted or received placebo again. The animals were challenged by inoculating 107 CFU/mL vegetative bacteria Clostridium perfringens type A intramuscularly. All animals were clinically evaluated two hours before inoculation and every two hours after this until 72 hours after the challenge. The assessment was made at times considered most important, with a total of seven observations. Subsequently, all animals were euthanized and necropsied immediately after to evaluate the changes. The clinical and autopsy parameters were defined by parameter and total score. When comparing the maximum clinical scores of the groups, it was determined that the Bacterin + Toxoid group (10.80) showed the best behavior, not finding a statistical difference when compared with the Negative Control group, followed by Toxoid group (13.13) and Commercial toxoid (13.25), with minor signs of illness. The Bacterin group was considered as inefficient, with the highest total score of the evaluated clinical vaccines (28.71), finding no statistical difference when compared with the Positive Control group. These results were also observed in the total score autopsy, with the best results being in Bacterin + Toxoid group (12.8), followed by Toxoid group (16.25), Commercial Toxoid (15.38), Bacterin (27.14), Negative Control (10.00) and positive control (29.57). In conclusion, the best immunization protocol was Bacterin + Toxoid. It is possible to assess the effectiveness of vaccines using this model and could be used as a standard for evaluating vaccines against Clostridium perfringens type A and other histotoxics clostridia that causes myonecrosis.
As mionecroses causadas por infecções do Clostridium perfringens tipo A são caracterizadas por curso rápido e letalidade alta, desconhecendo-se o impacto que tem tanto na pecuária nacional como mundial. Objetivou-se com o presente trabalho estabelecer um modelo de indução experimental da gangrena gasosa por meio da inoculação de bactérias vegetativas do Clostridium perfringens tipo A. Assim como também, avaliar a eficácia de três vacinas experimentais (Toxóide, Bacterina, Bacterina + Toxóide) e uma de origem comercial. Utilizando 98 cobaias (Cavia porcellus) albinas da linhagem English short ear, machos, com peso entre 300 e 500 gramas. Dessas, 50 foram utilizadas para estabelecer a dose de desafio e 48 para a avaliação da eficácia das vacinas. Para reprodução experimental da mionecrose em cobaios, produção da bacterina e do toxóide utilizou-se uma amostra de referência do American Type Culturet colecction2 de Clostridium perfringens tipo A (ATCC 13124), pertencente à bacterioteca do Laboratório de Anaeróbios da EV-UFMG. A totalidade dos cobaios (48) foram divididos em seis grupos, administrando um mL por via subcutânea do imunógeno ou placebo no dia zero, e, no dia 21, após a primo vacinação, todos os grupos receberam um reforço ou placebo novamente. Foram desafiados os animais inoculando 107 UFC/ mL de bactérias vegetativas do Clostridium perfringens tipo A pela via intramuscular. Todos os animais foram avaliados clinicamente duas horas antes da inoculação e a cada duas horas depois deste momento, até 72 horas após o desafio. Foram utilizadas as avaliações feitas em momentos considerados de maior importância, totalizando sete observações. Posteriormente, todos os animais foram eutanasiados e imediatamente necropsiados e as alterações foram avaliadas. Os parâmetros clínicos e necroscópicos foram definidos em escore por parâmetro e totais. Quando comparados os escores clínicos máximos dos grupos, determinou-se que o grupo Bacterina + Toxóide (10,80) foi o que apresentou melhor comportamento, não encontrando-se diferença estatística quando comparado com o grupo Controle Negativo, seguido dos grupos Toxóide (13,13), Toxóide Comercial (13,25), apresentando sinais leves da doença. O grupo Bacterina foi considerado como ineficiente, apresentando o maior escore clínico total das vacinas avaliadas (28,71), não encontrando diferença estatística quando comparado com o grupo Controle Negativo. Estes resultados foram observados também no escore necroscópico total, sendo melhor o grupo Bacterina + Toxóide (12,8), seguido pelos grupos Toxóide (16,25), Toxóide Comercial (15,38), Bacterina (27,14), Controle Negativo (10,00) e Controle Positivo (29,57). Concluindo, o melhor protocolo de imunização foi Bacterina + Toxóide, é possível avaliar a eficácia de vacinas utilizando este modelo, podendo ser utilizado como padrão para avaliações de vacinas contra Clostridium perfringens tipo A e outros clostrídios histotóxicos causadores de mionecrose.
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5

Medel, Infante Manuel, and Morales José Luis Flores. "EXPERIENCIA EN EL MANEJO DE LA GANGRENA DE FOURNIER EN HOSPITAL GENERAL TOLUCA DEL P.R. DR. NICOLÁS SAN JUAN DEL 1 DE ENERO DEL 2007 AL 31 DE DICIEMBRE DEL 2012 “HOSPITAL GENERAL TOLUCA P.R. DR. NICOLÁS SAN JUAN”." Tesis de Licenciatura, Medicina-Quimica, 2013. http://hdl.handle.net/20.500.11799/14262.

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INTRODUCCIÓN: La gangrena de Fournier es una fascitis necrotizante fulminante y progresiva de origen polimicrobiano que afecta las regiones perianal, perineal, genital, abdominal y en el 95 % de los casos su etiología puede ser identificada. OBJETIVO: Analizar la experiencia en el manejo de pacientes con gangrena de Fournier en el Hospital General del P.R Toluca Dr. Nicolás San Juan. Durante 5 años. HIPOTESIS: Hipótesis de trabajo. Es un estudio descriptivo el cual no amerita hipótesis. MATERIAL Y MÉTODOS: Es un estudio observacional, descriptivo, transversal, analítico de los expedientes clínicos de pacientes de esta institución, con diagnostico de gangrena de Fournier, las variables que se analizaron fueron: edad, genero, causa de gangrena de fournier, numero de cirugías, tiempo entre eventos quirúrgicos, causa concomitante, índice de severidad (Laor) y antibiótico empleado. RESULTADOS: Se obtuvo una muestra de 14 pacientes en el periodo comprendido entre el 1 de enero del 2007 al 31 de diciembre del 2012. El intervalo de edad más afectado fue de 36-45 años, el género más común el masculino 13 (93%). La causa etiopatogenica mas común fue la urológica 8 (57%), la Diabetes Mellitus fue la comorbilidad mas común 8 (57%) y el antibiótico más usado fue cefalosporina de 3 generacion con 8 (57%) pacientes.
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6

Jepson, Marie Alice. "The role of the C-Domain of clostridium perfringens α-toxin." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247080.

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7

FRETILLERE, ERIC. "Les gangrenes gazeuses cervico-faciales : a propos de 11 cas." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25010.

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8

MARTELET, JEAN-LUC. "Contribution a l'etude des gangrenes foudroyantes des organes genitaux externes : le syndrome de fournier." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20105.

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9

GOUMET, JOCELYNE. "Nouvelle antibiotherapie dans le traitement des processus gangreneux et cellulitiques." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20077.

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10

DEBOEVERE, DENIS. "Gangrene gazeuse revelatrice d'une pathologie medicale : revue de la litterature a propos d'un cas." Amiens, 1988. http://www.theses.fr/1988AMIEM112.

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11

Irwin, Samuel Terence. "Physiological studies on blood flow in the diabetic foot." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254198.

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12

Forsans, Jean-Marc. "Gangrène périnéale infectieuse : à propos de 57 observations." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2M172.

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13

KHALIFA, SYLVIE. "La fasciite necrosante : revue de la litterature ; a propos d'un cas typique chez l'enfant et conduite a tenir en cas de suspicion de cette affection." Toulouse 3, 1990. http://www.theses.fr/1990TOU31196.

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14

Raynaud, Maurice. "De l'asphyxie locale et de la gangrène symétrique des extrémités thèse pour le doctorat en médecine présentée et soutenue le 25 février 1862 /." Paris : BIUM, 2003. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1862x036.

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15

Voiglio, Eric Joseph. "Le syndrome de meleney : quels progres en 70 ans ? a propos d'une serie de 21 cas." Lyon 1, 1993. http://www.theses.fr/1993LYO1M303.

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16

Therit, Blair H. "Investigation of the role of the toxins perfringolysin O (PFO) and sialidase in Clostridium perfringens gas gangrene infections." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/35136.

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Clostridium perfringens is the causative agent of gas gangrene. A lethal infection in mice requires a large inoculum suggesting that the immune system is involved in inhibiting disease. Human monocytic cells and neutrophils killed C. perfringens in vitro when complement was present. Macrophages and neutrophils co-localized with C. perfringens in vivo when bacterial numbers were low. Depletion of neutrophils and monocytes in mice revealed that monocytic cells play a role in inhibiting C. perfringens gas gangrene in mice infected with an intermediate dose. C. perfringens can persist in the tissues and this could be mediated by persistence within macrophages. To examine if the toxin perfringolysin O (PFO) could mediate this, less active variants of PFO were used to examine what occurs between phagosomal escape and cell lysis. The mutant forms of PFO did mediate phagosomal escape in macrophages and were found within macrophages at higher numbers than wild-type C. perfringens. Our data were preliminary but may indicate that less active PFO mediates intracellular persistence. To investigate the role of sialidase in C. perfringens gas gangrene we made nanI-, nanJ-, and nanI-/nanJ- mutants. We observed that NanI is responsible for the majority of sialidase activity of C. perfringens strain 13, that NanJ is an extracellular sialidase, and that these genes are transcriptionally regulated by sialic acid. Murine infection trials revealed that these sialidases may be protective for mice during infection. In conclusion, murine monocytes inhibit disease onset and C. perfringens sialidase enhances mouse survival. However, the toxin PFO if less active promotes the survival of C. perfringens with macrophages.
Master of Science
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BURGOS, Fábia Regina Nascimento Fernando. "Mastectomia radical e unilateral no tratamento de mastite gangrenosa em cabras." Universidade Federal Rural de Pernambuco, 2009. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5615.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
With the objective of to evaluate the radical and unilateral mastectomy as surgical procedure of choice in the treatment of the gangrenous mastitis four goats were used in the age from two to three years old, without defined race. All the animals went by clinical exam, bearers of gangrenous mastitis of acute course were considered varying from three to four post parturition days. Undergoing low epidural anesthesia and radical and unilateral mastectomy. In the bacterial culture of the samples of the milk milked in the preoperative period of the mammary gland not attacked by the gangrenous mastitis it was obtained the frequency of 25% (1/4) of each isolated microorganism, being respectively Staphylococcus sp. associated the Corynebacterium sp. , Streptococcus sp. , Corynebcterium sp. . In the bacterial culture of the secretion of the centre part of the parenchyma of the gangrenous mamma of each animal they were identified in the samples Corynebcterium sp. , Staphylococcus negative coagulate, Enterococcus faecalis and Staphylococcus sp. associated the Corynebacterium sp. with the frequency of 25%(1/4). To the exam histologyc of the parenchyma of the mammary gland the cuts revealed presence of coagulation necrosis, proliferation fibroblastic, collagen and infiltrated inflammatory mononuclear. Formation of plates hyalins under the vascular endothelium and dilation of the ducts excretorys of the mammary alveoli. Some "clusters" limited bacterial for conjunctive tissue. Hemorrhage and hemossiderosis in the mammary alveolus. Caseous material in the light of some ducts excretorys. In other,roseates was observed. The time of postoperative observation was of 18 months. With the employed procedure the vital recovery of the operated animals was shown. It was ended that the mastectomy, radical and unilateral, it is rendered for the treatment of the gangrenous mastiti. It is essential the adoption of measures practices of low cost that facilitate the life of the producers reducing your expenses. The perspective that this work serves as subsidy for the preservation in the flock of animals of high genetic lineage.
Com o objetivo de avaliar a mastectomia radical e unilateral como procedimento cirúrgico de escolha no tratamento da mastite gangrenosa foram utilizadas quatro cabras, na faixa etária de dois a três anos de idade, sem raça definida. Todos os animais passaram por exame clínico, foram considerados portadores de mastite gangrenosa de curso agudo variando de três a quatro dias pós-partos. Submetidas à anestesia epidural baixa e mastectomia radical e unilateral. Na cultura bacteriana das amostras do leite ordenhado no período pré-operatório da glândula mamária não acometida pela mastite gangrenosa obteve-se a frequência de 25% (1/4) de cada microrganismo isolado, sendo respectivamente Staphylococcus sp. associado a Corynebacterium sp., Streptococcus sp., Corynebcterium sp.. Na cultura bacteriana da secreção da parte central do parênquima da mama gangrenosa de cada animal foram identificados nas amostras Corynebcterium sp., Staphylococcus coagulase negativa, Enterococcus faecalis eStaphylococcus sp. associado a Corynebacterium sp. com a frequência de 25% (1/4). Ao exame histológico do parênquima da glândula mamária os cortes revelaram presença de necrose de coagulação, proliferação fibroblástica, colágeno e infiltrado inflamatório mononuclear. Formação de placas hialinas sob o endotélio vascular e dilatação dos ductos excretores dos alvéolos mamários. Alguns “clusters” bacterianos limitados perifericamente por tecido conjuntivo. Hemorragia e hemosiderose no alvéolo mamário. Material caseoso na luz de alguns ductos excretores. Em outros, observou-se rosetas. O tempo de observação pós-operatória foi de 18 meses. Com o procedimento empregado mostrou-se a recuperação vital dos animais operados. Concluiu-se que a mastectomia, radical e unilateral, se presta para o tratamento da mastite gangrenosa. É essencial a adoção de medidas práticas de baixo custo que facilitem a vida dos produtores diminuindo seus gastos. Têm-se a perspectiva de que este trabalho sirva de subsídiopara a preservação no rebanho de animais de alta linhagem genética.
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Frank, Nora Philine [Verfasser]. "Fournier'sche Gangrän - Retrospektive Analyse in einer Multicenteruntersuchung / Nora Philine Frank." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2012. http://d-nb.info/102756741X/34.

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19

Bain, Ruairidh Andrew. "Factors influencing the resistance of potato cultivars to the gangrene pathogen, Phoma exigua Desm. var. foveata (Foister) Boerema." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/26188.

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This study was concerned with factors affecting the development of potato gangrene caused by Phoma exigua var. foveata, with particular reference to the assessment of cultivar resistance to the disease. The factors considered were isolate pathogenicity, tuber inoculum level, tuber damage, method of inoculation and assess?ment, incubation temperature and tuber tissue and damage resistance. In addition the influence of isolate and cultivar on the transmission of inoculum from seed to progeny tubers was assessed. The importance of using isolates of high pathogenicity to detect differences in resistance among cultivars was emphasised. Variation in pathogenicity among isolates was associated with isolate source and history, but there was no evidence of consistent cultivar x isolate inter?actions of an order to suggest physiological specialisa?tion in this pathogen. In considering the relative contribution of isolate and cultivar to variation in disease development the contribution of isolate was much less than that of cultivar. The relative resistances of cultivars depended to some extent on inoculation technique and assessment method. This indicated the existence of two major components of tuber resistance, namely damage and tissue resistance. There was also evidence that the relative susceptibilities of cultivars could differ for the tuber cortex and medulla: thus some cultivars mayhave lesions with a small surface area but an appreciable depth of penetration whereas others show wide, shallow rots. The actual level of gangrene depended upon the interaction between cultivar, tuber damage and tuber inoculum density. High inoculum doses coupled with inoculation techniques which allowed the expression of cultivar damage resistance were the most useful in discriminating among cultivars. However, with some assessment methods cultivar differences were obscured at high inoculum densities. Incubation temperature also influenced the course of disease development. At higher incubation temperatures (lO?C) lesions were arrested in all cultivars tested whereas at lower temperatures (4?C) cultivars showed differences in tissue resistance reflected in the degree of lesion retardation but rot development continued in all cultivars. In attempts to gain further evidence of tissue resistance factors gamma irradiation studies were carried out. Irradiation of tubers reduced their resistance to gangrene to an extent dependent upon the irradiation dose and the delay, after irradiation, between wounding and inoculation. There was evidence that wound periderm formation was of minor importance in tissue resistance and that irradiation?induced susceptibility 3.was not associated with tuber cell death. Transmission of P. exigua var. foveata from seed to daughter tubers was shown to be affected by isolate and cultivar but further work is required in this area.
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20

Gatsos, Xenia, and xgatsos@optusnet com au. "The development of live vectored vaccines targeting the alpha-toxin of Clostridium perfringens for the prevention of necrotic enteritis in poultry." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080212.142403.

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The ƒÑ-toxin of Clostridium perfringens is a toxin involved in numerous diseases of humans and agriculturally important animals. One of these diseases is necrotic enteritis (NE), a sporadic enteric disease which affects avian species world-wide. This study involved the inactivation of alpha-toxin (ƒÑ-toxin) for use as a potential vaccine candidate to combat NE in chickens, and other diseases caused by C. perfringens type A. During the course of this research a number of ƒÑ-toxin recombinant proteins were developed through molecular inactivation of the ƒÑ-toxin gene, plc. Proteins plc316 and plc204 were developed by the deletion of the first three and seven ƒÑ-helices of the N-terminal domain respectively. These deletions resulted in proteins which were unstable in solution, constantly aggregated into insoluble masses and elicited lower overall antibody responses when administered to mice. A third protein, plcInv3 was developed from the deletion of part of the catalytic domain of the ƒÑ-toxin. PlcInv3 was highly soluble and upon immunisation of mice elicited a significant antibody response which was also capable of protecting mice against a live challenge of C. perfringens. The fourth and final protein developed was plc104. The smallest of the recombinant ƒÑ-toxin proteins, it consisted entirely of the C-terminal domain of ƒÑ-toxin. Its small size did not affect its ability to induce a strong antibody response when administered to mice, the antibodies of which were also protective during a challenge with C. perfringens. STM1, an attenuated strain of S. Typhimurium was used in the development of a vectored vaccine for the expression and oral delivery of plcInv3 and plc104 within the mouse host. The proteins were expressed within STM1 from expression plasmids containing the in vivo inducible promoters PhtrA and PpagC. A measurable humoral immune response against ƒÑ-toxin was absent following three oral vaccinations with the vectored vaccines, although, cytokine profiling of splenocytes from vaccinated mice revealed an increase in the number of interleukin-4 (IL-4)secreting cells and the lack of interferon-gamma (IFN-ƒ×) secreting cells. This indicated the stimulation of a T-helper type 2 (TH2) immune response which also lead to partial protection against a live C. perfringens challenge. This study demonstrates the feasibility of using STM1 as a carrier for the in vivo expression of the C. perfringens ƒÑ-toxin recombinant proteins plcInv3 and plc104. It is the first study to express C. perfringens antigens within an attenuated strain of S. Typhimurium, STM1.The partial protection of mice immunised with these vaccines indicates there is potential for this vectored vaccine system to be used in the protection of diseases caused by the ƒÑ-toxin of C. perfringens.
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21

Verdier, Eric. "Bilan de trois ans d'activité de la chambre hyperbare de Perpignan." Montpellier 1, 1990. http://www.theses.fr/1990MON11076.

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22

Nour-El-Din, Andreas. "Eine retrospektive Verlaufsanalyse sowie prospektive Fallbeobachtung zur retrograd venösen Perfusion als Therapieoption der diabetischen Gangrän und anderer infizierter Läsionen der Extremitäten." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78158.

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23

Schirdewan, Charlotte [Verfasser], Arne [Akademischer Betreuer] Strauss, Rolf-Hermann [Akademischer Betreuer] Ringert, Helmut [Akademischer Betreuer] Eiffert, and Patricia [Akademischer Betreuer] Virsik-köpp. "Fournier-Gangrän: Krankheitsverlauf in Abhängigkeit von Komorbiditäten und Therapie / Charlotte Schirdewan. Gutachter: Rolf-Hermann Ringert ; Helmut Eiffert ; Patricia Virsik-Köpp. Betreuer: Arne Strauss." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1043513671/34.

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24

Chávez, Sánchez Wendy. "Leucocitosis asociada a grado de severidad y linfopenia asociada a apendicitis gangrenosa en pacientes con diagnóstico de apendicitis aguda en el servicio de cirugía del Hospital Vitarte durante el período enero – julio 2015." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/498.

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OBJETIVO: Determinar la asociación entre leucocitos más linfopenia con el grado de severidad en los pacientes con diagnóstico de Apendicitis Aguda atendidos en el Servicio de Cirugía durante período Enero - Julio 2015 en el Hospital Vitarte. MATERIALES Y MÈTODOS: Se realizó un estudio de tipo Observacional – Transversal – Retrospectivo – Descriptivo. Se tomaron 252 historias registradas durante el período enero – julio del 2015, de las cuales, 27 fueron eliminadas por estar incompletas. El método que se realizó para la recolección de datos consistió en la evaluación de las historias clínicas. RESULTADOS: La frecuencia de apendicitis aguda en los pacientes del servicio de cirugía fue de 85.8%. En cuanto a la frecuencia de leucocitosis fue del 81.3%, mientras que la linfopenia tuvo una frecuencia de 84.9% CONCLUSIONES: La leucocitosis está asociada al grado de severidad de apendicitis y asimismo la linfopenia muestra asociación con la apendicitis gangrenosa en un porcentaje altamente significativa
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25

Kufahl, Marleen [Verfasser]. "Zelluläre und subzelluläre Expression und Phosphorylierung der MAP-Kinase ERK1/2 in Odontoblasten der gesunden und der durch Dentinkaries, Caries profunda und Gangrän entzündlich veränderten humanen Dentin-Pulpa-Einheit / Marleen Kufahl." Köln : Deutsche Zentralbibliothek für Medizin, 2017. http://d-nb.info/1138792128/34.

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26

Schirdewan, Charlotte. "Fournier-Gangrän: Krankheitsverlauf in Abhängigkeit von Komorbiditäten und Therapie." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-EFF2-0.

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Die Fournier-Gangrän ist definiert als nekrotisierende Fasciitis der perinealen, genitalen oder perianalen Region, die oft durch eine synergistische Mischinfektion aus aeroben und anaeroben Erregern verursacht wird. Ihr potenziell lethaler Verlauf verlangt eine frühzeitige und aggressive chirurgische Intervention sowie eine dreifache Breitbandantibiose. Es wurden 19 Verläufe retrospektiv ausgewertet für die Erstellung eines Therapie-Algorithmus. Patienten mit höchstens einer Prädisposition zeigen eine signifikant erniedrigte Mortalität gegenüber Patienten mit mehreren Vorerkrankungen. Eine vacuum-assisted closure-Therapie (VAC) kann hinweislich trotz verlängerter stationärer Verweildauer und erhöhter Operationsanzahl die Mortalität wesentlich senken. Durch eine Therapieinitiierung vor dem fünften postoperativen Tag kann die Länge der VAC-Therapie und damit auch die Länge der stationären Behandlung sowie die Operationsanzahl gesenkt werden. Der Fournier Severity Index (FSI) setzt sich aus neun laborchemischen und klinischen Parametern zusammen und kann zur Abschätzung der Prognose eingesetzt werden.
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Oliveira, Carlos Macedo Cardoso de. "Fournier's gangrene- An overview of predictive factors for mortality in a large contemporary series." Dissertação, 2018. https://repositorio-aberto.up.pt/handle/10216/112308.

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Oliveira, Carlos Macedo Cardoso de. "Fournier's gangrene- An overview of predictive factors for mortality in a large contemporary series." Master's thesis, 2018. https://hdl.handle.net/10216/112308.

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Sohn, Maximilian [Verfasser]. "Untersuchung von Krankheitsverlauf, Management und postoperativer Lebensqualität von Patienten mit Fournier'scher Gangrän / Maximilian Sohn." 2008. http://d-nb.info/988502836/34.

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30

Kommissari, Stefan [Verfasser]. "Die retrograde venöse Perfusion : Therapieoption der diabetischen Gangrän und anderer infizierter Läsionen der Extremitäten / vorgelegt von Stefan Kommissari." 2002. http://d-nb.info/966640268/34.

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31

Nour-el-Din, Andreas [Verfasser]. "Eine retrospektive Verlaufsanalyse sowie prospektive Fallbeobachtung zur retrograd venösen Perfusion als Therapieoption der diabetischen Gangrän und anderer infizierter Läsionen der Extremitäten / vorgelegt von Andreas Nour-El-Din." 2007. http://d-nb.info/987858181/34.

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