Relevant bibliographies by topics / Gárdos channel

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Gárdos channel'

Author: Grafiati
Published: 4 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Gárdos channel"

1

Petkova-Kirova, Polina, Nicoletta Murciano, Giulia Iacono, et al. "The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells." International Journal of Molecular Sciences 25, no. 3 (2024): 1416. http://dx.doi.org/10.3390/ijms25031416.

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The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in the red blood cell (RBC) membrane. Nevertheless, the quantitative electrophysiological behavior of RBCs and its heterogeneity are still not completely understood. Here, we use state-of-the-art biochemical methods to probe for the abundance of the channels in RBCs. Furthermore, we utilize automated patch clamp, based on planar chips, to compare the activity of the two channels in reticulocytes and mature RBCs. In addition to this characterization, we performed membrane potential measurements to demonstrate the effect of ch
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2

Jansen, Julia, Min Qiao, Laura Hertz, et al. "Mechanistic ion channel interactions in red cells of patients with Gárdos channelopathy." Blood Advances 5, no. 17 (2021): 3303–8. http://dx.doi.org/10.1182/bloodadvances.2020003823.

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Abstract In patients with Gárdos channelopathy (p.R352H), an increased concentration of intracellular Ca2+ was previously reported. This is a surprising finding because the Gárdos channel (KCa3.1) is a K+ channel. Here, we confirm the increased intracellular Ca2+ for patients with the KCa3.1 mutation p.S314P. Furthermore, we provide the concept of KCa3.1 activity resulting in a flickering of red blood cell (RBC) membranepotential, which activates the CaV2.1 channel allowing Ca2+ to enter the RBC. Activity of the nonselective cation channel Piezo1 modulates the aforementioned interplay in away
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3

Maher, Anthony D., and Philip W. Kuchel. "The Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytes." International Journal of Biochemistry & Cell Biology 35, no. 8 (2003): 1182–97. http://dx.doi.org/10.1016/s1357-2725(02)00310-2.

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4

Buks, Ralfs, Tracy Dagher, Maria Rotordam, et al. "Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis." Cells 11, no. 1 (2021): 49. http://dx.doi.org/10.3390/cells11010049.

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Over 95% of Polycythemia Vera (PV) patients carry the V617F mutation in the tyrosine kinase Janus kinase 2 (JAK2), resulting in uncontrolled erythroid proliferation and a high risk of thrombosis. Using mass spectrometry, we analyzed the RBC membrane proteome and showed elevated levels of multiple Ca2+ binding proteins as well as endoplasmic-reticulum-residing proteins in PV RBC membranes compared with RBC membranes from healthy individuals. In this study, we investigated the impact of JAK2V617F on (1) calcium homeostasis and RBC ion channel activity and (2) protein expression and sorting durin
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5

Maher, Anthony D., and Philip W. Kuchel. "Erratum to “The Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytes” [Int. J. Biochem. Cell Biol. 35 (2003) 1182–1197]." International Journal of Biochemistry & Cell Biology 35, no. 12 (2003): 1682. http://dx.doi.org/10.1016/s1357-2725(03)00209-7.

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6

Monedero Alonso, David, Laurent Pérès, Aline Hatem, Guillaume Bouyer, and Stéphane Egée. "The Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions." Frontiers in Physiology 12 (October 11, 2021). http://dx.doi.org/10.3389/fphys.2021.743094.

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Handbooks of physiology state that the strategy adopted by red blood cells (RBCs) to preserve cell volume is to maintain membrane permeability for cations at its minimum. However, enhanced cation permeability can be measured and observed in specific physiological and pathophysiological situations such as in vivo senescence, storage at low temperature, sickle cell anemia and many other genetic defects affecting transporters, membrane or cytoskeletal proteins. Among cation pathways, cation channels are able to dissipate rapidly the gradients that are built and maintained by the sodium and calciu
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7

Hatem, Aline, Gwendal Poussereau, Martin Gachenot, Laurent Pérès, Guillaume Bouyer, and Stéphane Egée. "Dual action of Dooku1 on PIEZO1 channel in human red blood cells." Frontiers in Physiology 14 (July 10, 2023). http://dx.doi.org/10.3389/fphys.2023.1222983.

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PIEZO1 is a mechanosensitive non-selective cation channel, present in many cell types including Red Blood Cells (RBCs). Together with the Gárdos channel, PIEZO1 forms in RBCs a tandem that participates in the rapid adjustment of the cell volume. The pharmacology allowing functional studies of the roles of PIEZO1 has only recently been developed, with Yoda1 as a widely used PIEZO1 agonist. In 2018, Yoda1 analogues were developed, as a step towards an improved understanding of PIEZO1 roles and functions. Among these, Dooku1 was the most promising antagonist of Yoda1-induced effects, without havi
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8

Hertz, Laura, Daniel Flormann, Lutz Birnbaumer, Christian Wagner, Matthias Laschke, and Lars Kaestner. "Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept." Blood Advances, December 9, 2022. http://dx.doi.org/10.1182/bloodadvances.2022008404.

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For some molecular players in red blood cells, the functional indications and molecular evidence are discrepant. One such protein is transient potential receptor channel of canonical type 6 (TRPC6). Transcriptome analysis of reticulocytes revealed the presence of TRPC6 in mouse red blood cells and its absence in human red blood cells. We transfused TRPC6 knockout (KO) red blood cells into wild-type (WT) mice and performed functional tests; we observed the 'rescue' of TRPC6 within 10 days but slower TRPC6 'rescue' in splenectomized mice. The latter finding led us to mimic the mechanical challen
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9

Bernhardt, Ingolf, and Lars Kaestner. "Historical View and Some Unsolved Problems in Red Blood Cell Membrane Research." Frontiers in Bioscience-Landmark 30, no. 3 (2025). https://doi.org/10.31083/fbl25331.

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The article provides a comprehensive overview of biological membrane lipid composition and distribution and ion transport processes, focusing particularly on red blood cells (RBCs). It begins with a historical perspective, detailing the introduction of the terms ‘cell’ and ‘membrane’ in biological sciences, and the development of the fluid-mosaic model of membrane structure. Early findings on ion transport highlighted the non-equilibrium distribution of Na+ and K+ across cell membranes, leading to the discovery of the Na+/K+ pump. The article delves into the lipid composition of RBC membranes,
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Dissertations / Theses on the topic "Gárdos channel"

1

Hatem, Aline. "Characterization of cationic conductance in Red Blood Cells; insights from pharmacological and pathophysiological studies." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS008.

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Au cours de leur vie, les érythrocytes circulent dans tout le corps pour transporter les gaz respiratoires et remplir leurs autres fonctions. Par conséquent, les érythrocytes doivent être capable de se déformer correctement pour circuler dans tous les vaisseaux, y compris les plus petits capillaires. Cette capacité est régie par un réseau complexe associant les protéines de la membrane et du cytosquelette combiné à un rapport surface-volume finement ajusté, permettant ainsi des changements de forme instantanés pour permettre un transit rapide des GR. Cela montre à quel point il est important d
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