To see the other types of publications on this topic, follow the link: Garoja (cantor).
Journal articles on the topic 'Garoja (cantor)'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Garoja (cantor).'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
García, Luz Stella, Luis Eduardo Bravo, Paola Collazos, et al. "Cali Cancer Registry Methods." Colombia Médica 49, no. 2 (2018): 188. http://dx.doi.org/10.25100/cm.v49i2.4056.
Full textAbstract:
In this article by Garcia et al, On corresponding author is incorrect: “Luz Stella Garcia, Registro Poblacional de Cancer de Cali. Calle 4B 31-00 Oficina 4003, Edificio 116, Cali, Colombia. E-mail: luz.garcia@correounivalle. edu.co.” The correct corresponding author should be: “Luis Eduardo Bravo, Director Registro Poblacional de Cáncer de Cali. Calle 4B 31-00 Oficina 4003, Edificio 116, Cali, Colombia. E-mail: luis.bravo@correounivalle.edu.co”
2
García Bustos, Teresa. "Imayo, los cantos de las prostitutas: la visibilización de las asobi y kugutsu y su producción lírica." Fuentes Humanísticas 32, no. 60 (2020): 47–60. http://dx.doi.org/10.24275/uam/azc/dcsh/fh/2020v32n60/garcia.
Full text
3
Jiralerspong, Sao, and Ana M. Gonzalez-Angulo. "Reply to A. Garcia et al." Journal of Clinical Oncology 28, no. 2 (2010): e20-e20. http://dx.doi.org/10.1200/jco.2009.25.8491.
Full text
4
Herr, Martha. "Resenha sobre o livro O canto antigo italiano." Per Musi, no. 15 (January 1, 2007): 93–94. https://doi.org/10.35699/2317-6377.2007.55196.
Full textAbstract:
The book The Ancient Italian Song: a Comparative Analysis of the Singing Treatises by Pier Tosi, Giambattista Mancini, and Manuel P. R. Garcia by Alberto Pacheco was recently published by Annablume Publishing (ISBN 85-7419-605-3), with funding from FAPESP, as part of the Selo Universidade collection. This book is an edition of the master's dissertation defended by Pacheco in 2004 at UNICAMP, where he is currently preparing for his doctorate.
5
Recouvreux, Maria Sol, and Sandra Orsulic. "Before They Were Malignant." Cancer Discovery 15, no. 6 (2025): 1093–95. https://doi.org/10.1158/2159-8290.cd-25-0429.
Full textAbstract:
Summary: A lack of understanding of how ovarian cancer originates in fallopian tube cells has hindered early detection and prevention, often resulting in diagnosis at advanced stages when treatment options are limited. In this issue of Cancer Discovery, two studies uncover critical microenvironmental changes that drive tumor initiation and progression, offering potential targets for earlier intervention. See related article by Kader et al., p. 1180 See related article by Garcia et al., p. 1203
6
Lagaña, Liliana. "Como bola de neve." TRAVESSIA - revista do migrante, no. 32 (December 14, 1998): 5–10. http://dx.doi.org/10.48213/travessia.i32.620.
Full textAbstract:
Era janeiro. Havia nevado e os bosques ao redor estavam lindos, com aquelas manchas de neve e um silêncio grande. Eu tinha ido dar uma volta sozinho, para me despedir das ruas da minha aldeia, das casas que conhecia uma a uma, dos cantos que tinham sido meus refúgios de menino, da Fontana Vecchia, do velho carvalho à entrada da aldeia... Caminhava assim quando vi uma garota que eu conhecia. Me aproximei para me despedir, porque eu ia partir aquele dia, disse para ela, eu ia para a América, para o Brasil. Mas ela, em lugar de apertar a mão que lhe estendia, agachou-se, pegou uma bola de neve, a jogou na minha cara com força de doer e saiu correndo sem dizer uma palavra, deixando-me ali parado, feito bobo, a mão ainda estendida e aquele gelo de neve na cara. [...]
7
José, Manuel Gamboa. "El mairenismo." Música Oral del Sur, no. 6 (December 8, 2005): 105–17. https://doi.org/10.5281/zenodo.4629876.
Full textAbstract:
Antonio Cruz García, Antonio Mairena, nació el 5 de septiembre de 1909 en el pueblo sevillano de Mairena del Alcor, hijo del primer matrimonio del gitano herrero Rafael Cruz Vargas con Aurora García Heredia. Hermano, por tanto, de Águila, Juan, Rosario, María Josefa y Curro Mairena; hermano, por la parte paterna, de Ángeles y Manuel. Tenía familia en Brenes, Arahal, Paradas, Ecija... Sus antepasados venían de El Coronil... Antonio Mairena, amén de ser ese cantaor sobresaliente, nos ha legado, entre otras materias cantaoras, la más amplia obra seguiriyera y solearera de todos los tiempos, fue creador del ismo que va a caraceterizar la llamada etapa de la flamencología. Porque el mairenismo no es sólo una forma de interpretar el flamenco; es toda una teoría genealógica del cante y una concepción geográfica de su ámbito. En la figura insigne de Antonio Mairena, se conjugan dos vertientes igualmente sobresalientes: la de cantaor fuera de serie y la de ideólogo activista con grandes habilidades para el proselitismo. Es esta segunda en la que nos vamos a centrar. En los años sesenta y setenta florece, al calor de Antonio, una manera de inrerpretar el cante grave y solemne, en la cual el marchamo gitano-bajo-andaluz cobra especial valor. La labor flamenca de Mairena sirvió también, no se puede olvidar, para dignificar una profesión que empezó a ser más «lucrativa». En los festivales flamencos veraniegos de Andalucía, donde Mairena centró su actividad y a los que hizo prosperar sobremanera, los artistas pudieron ver aumentada su categoría como músicos y, en consecuencia, alcanzar la debida remuneración económica por su participación en ellos. Los festivales, en gran medida, acabarán con la iniciativa privada pues eran subvencionados por los ayuntamientos locales. Sustituirán a los bolos de las estrellas del ane sureño (los que ahora reverdecen tantos y tantos recuerdos en el "Cine de barrio" de una suburbial TVE). Gracias a los festivales mandan en el escenario cantes que habían quedado arrinconados por su escaso rirón popular. Consecuentemente también se arrinconan otras formas de sonar y de decir, que son también parte inherente del arte flamenco
8
Melo Rocha, Rose. "Remediação com purpurina: bricolagens tecnoestéticas no drag-artivismo de Gloria Groove." INTERIN 23, no. 1 (2018): 205–20. http://dx.doi.org/10.35168/1980-5276.utp.interin.2018.vol23.n1.pp205-220.
Full textAbstract:
Discute-se neste artigo a audiovisibilidade midiática da cantora drag paulistana Gloria Groove, nome artístico de Daniel Garcia, como exemplo de remediação tecnoestética em contextos pós-massivos. A prática artivista e as estratégias mercadológicas de Groove expressam uma habilidade bricoladora, na qual a presença no mainstream ou a larga repercussão de seu trabalho e da midiatização de suas narrativas existenciais não exclui as potencialidades críticas materializadas na junção entre corporalidade drag (travestida) e corporalidade gay (desmontada). É assim constituída uma politicidade do entre(tenimento).
9
Tagne Simo, Richard, Erika Myriam Baiguerel, Armel Hervé Nwabo Kamdje, et al. "Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon." International Journal of Breast Cancer 2021 (July 27, 2021): 1–7. http://dx.doi.org/10.1155/2021/6663195.
Full textAbstract:
Breast cancer has become a real public health problem in Cameroon, particularly in rural areas due to late diagnosis, resulting partly from the absence of national screening programs. This work is aimed at assessing breast cancer awareness in the North Region of Cameroon. Participants were selected in six health centers surrounding the rural area of Garoua, North Region, Cameroon, and administered a questionnaire aimed at assessing their awareness about breast cancer risk factors and screening. Out of the 475 women (including 37 medical personnel) interviewed, 45.5% attended at least secondary school; 91.3% were aware of the disease with the main sources of information from those around them (64.8%), media (46.5%), and health professionals in health facilities (42.7%). 23.3% had misconceptions and myth-based ideas on the origin of the disease. Ignorance was the main reason preventing the performance of breast self-examination, and the high cost prevents individuals from going for mammography. The highest awareness rate was observed in employed women with higher level of education. Our study highlights the need to raise awareness among the populations in North Region, Cameroon, about the risk factors and clinical signs of breast cancer and the importance of screening practice for early diagnosis of breast cancer.
10
Butsch Kovacic, Melinda, Alique Topalian, and Melissa Erickson. "Opportunities to Improve HPV Vaccination Among Pediatric, Adolescent, and Young Adult Cancer Survivors by Engaging both Oncology and Primary Care Teams." Cancer Prevention Research 16, no. 10 (2023): 545–47. http://dx.doi.org/10.1158/1940-6207.capr-23-0309.
Full textAbstract:
Abstract The incidence of second primary cancers is rising particularly among pediatric, adolescent, and young adult (PAYA) cancer survivors. While human papillomavirus (HPV)-associated cancers can be prevented by vaccination, their uptake is lower and delayed in this group. Because a recommendation from a health care provider is the strongest predictor of HPV vaccination, there are great opportunities for PAYA cancer care providers to positively impact HPV vaccination rates. Prioritizing PAYA cancer care provider education as well as improving the education of and coordination with primary care providers are viewed as opportunities to encourage HPV vaccine uptake and prevent future cancers. See related article by Garcia et al., p. 581
11
Arata, Stefano. "Candor y tragedia: Federico García Lorca y la poética de La Barraca." Bulletin of the Comediantes 73, no. 1 (2021): 51–68. http://dx.doi.org/10.1353/boc.2021.0004.
Full text
12
Venkat, Aarti, Pauline Ribeyre, Jawad Qureshi, et al. "Abstract 6242: A workflow execution system in a data fabric for integrative cancer analyses." Cancer Research 84, no. 6_Supplement (2024): 6242. http://dx.doi.org/10.1158/1538-7445.am2024-6242.
Full textAbstract:
Abstract Cancer researchers are increasingly conducting multi-omic research and performing integrative analyses on combinations of genomic, proteomic, transcriptomic, imaging, single cell and other data modalities. However, it is quite challenging for a researcher to effectively access, aggregate and analyze data and metadata from different data sources in a scalable and reproducible manner, as the individual datasets may be disconnected from each other, and have separate authentication and authorization requirements. We developed a workflow execution system in a data fabric called the Biomedical Research Hub (BRH) to overcome these challenges for academic researchers. The BRH is powered by the Gen3 technology, an open-source Kubernetes based software stack that allows cancer researchers to create their own data fabric and interoperate with data from multiple data sources. The workflow execution system utilizes nextflow and allows researchers to run containerized applications in the cloud in a secure and isolated environment. Data from multiple resources can be combined for analysis using convenient pay models including NIH STRIDES. We plan to demonstrate the application of our system on a scientific use case involving Clonal Hematopoiesis of Indeterminate potential (CHIP), a phenomenon that has been associated with aging, cancer, cardiovascular diseases, infection and all-cause mortality. We run containerized CHIP workflows on the cloud, utilizing two datasets accessible through BRH: i) The Genomic Data Commons, the world’s largest source of harmonized cancer data and ii) BioDataCatalyst, an NHLBI ecosystem that drives discovery and innovation for heart, lung, blood and sleep disorders. Our system is ideally suited for machine learning on large aggregated cancer datasets and federated learning tasks. Citation Format: Aarti Venkat, Pauline Ribeyre, Jawad Qureshi, Sai Shanmukha Narumanchi, J Montgomery Maxwell, Bill Winslow, Sara Volk Garcia, Chris Meyer, Tzintzuni Garcia, Peter Vassilatos, Clinton Malson, Zhenyu Zhang, Robert Grossman. A workflow execution system in a data fabric for integrative cancer analyses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6242.
13
Garcia, Noemi Garcia, Thanh Ha Vy Nguyen, Dane Richey, and Katie R. Ryan. "Abstract 2649: Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 2649. https://doi.org/10.1158/1538-7445.am2025-2649.
Full textAbstract:
Abstract The purpose of this study is to investigate whether the atypical Rho GTPase, Rnd3, affects triple-negative breast cancer (TNBC) cells metastatic potential (invasion and migration rates). One of the most dangerous attributes of cancer is its ability to metastasize and spread. The 5-year survival rate for localized breast cancer is 90%. However, this drops to 29% when breast cancer metastasizes. Identifying key regulatory proteins and signaling pathways involved in cell migration and invasion, two hallmarks of metastasis, will pave the way to potential therapeutic targets for reducing the metastatic potential of breast cancer. Rho GTPases regulate cellular processes that are commonly dysregulated in cancer with many studies focusing on what roles these proteins play in tumorigenesis. The expression level of the atypical Rho GTPase, Rnd3, rather than Rnd3 mutations, has been linked to cancer. High expression of Rnd3 increases cellular migration and invasion in several cancers, while depletion of Rnd3 decreases cellular proliferation and migration. How Rnd3 expression affects breast cancer progression is unknown. Here we assayed a panel of TNBC cell lines and assessed their migration and invasion potential, we observed a correlation of high Rnd3 expression and high cell migration and invasion rates. After knocking down Rnd3 expression in these cell lines we observed a significant reduction in cell invasion in MB-231, HCC1937, and MCF7 cells, and decreased cell migration in MB-231 cells. Rnd3 has been shown to regulate cell migration via the RhoA-ROCK1 pathway in melanoma. We were unable to rescue invasion rates in Rnd3 knockdown MB-231 cells following either chemical inhibition or knockdown of ROCK1, indicating Rnd3 is regulation cell invasion via a novel pathway in TNBC cells. Our findings indicate that Rnd3 regulates cell invasion and migration, two hallmarks of metastasis, in TNBC cells. Citation Format: Noemi Garcia Garcia, Thanh Ha Vy Nguyen, Dane Richey, Katie R. Ryan. Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2649.
14
Garcia, Noemi Garcia, Thanh Ha Vy Nguyen, Dane Richey, Cody Ashby, Analiz Rodriguez, and Katie R. Ryan. "Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner." Cancer Research 85, no. 8_Supplement_1 (2025): 2645. https://doi.org/10.1158/1538-7445.am2025-2645.
Full textAbstract:
Abstract The purpose of this study is to investigate how altered expression levels of the small Rho GTPase, Rnd3, affects lung cancer cells. Lung cancer is among the most common and deadliest forms of cancer in the US. Most lung cancers metastasize, with lung to brain metastasis being the number one killer of lung cancer patients. Studying mechanisms that drive metastatic potential is key to unlocking new strategies for the treatment of this deadly form of cancer. Our focus for this study is Rnd3, an atypical GTPases, which has roles in regulating proliferation and cell migration in other cancer types. Our analysis of The Cancer Genome Atlas data predicts that lung adenocarcinoma patients with low levels of Rnd3 have significant higher survival rate. We investigated the role of Rnd3 by depleting its expression in the lung adenocarcinoma cell line (A549), and also patient-derived lung to brain metastasis (PDLBM) cell lines (601 and 620) as a proxy for advance disease. We observed no significant difference in cell viability or cell cycle progression between Rnd3-depeled and control groups. We did observe a significant effect on cell invasion and migration, Rnd3 depletion significantly decreases cell invasion and migration across all three tested cell lines. Previous studies on Rnd3 in melanoma cells found that Rnd3 signals via the RhoA-ROCK1 pathway, which impacts cell adhesion and the actin cytoskeleton, ultimately regulating cell invasion. However, when we either chemically inhibited ROCK1 or knocked down ROCK1 expression in our lung adenocarcinoma and PDLBM cells, it did not rescue the invasive phenotype. Our findings indicate that Rnd3 regulates cell invasion and migration, two hallmarks of metastasis, in lung cancer via a distinct pathway, independently from ROCK1. Identifying this novel mechanism will provide crucial insights for developing treatment for lung cancer metastasis. Citation Format: Noemi Garcia Garcia, Thanh Ha Vy Nguyen, Dane Richey, Cody Ashby, Analiz Rodriguez, Katie R. Ryan. Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2645.
15
Díaz Marroquín, Lucía. "Técnica dramática y retórica de las pasiones en el Tratado completo del arte del canto de Manuel García." Anuario Musical, no. 62 (December 30, 2007): 271. http://dx.doi.org/10.3989/anuariomusical.2007.62.26.
Full textAbstract:
Desde los orígenes italianos del stile rappresentativo y del drama musical, en los últimos años del siglo XVI y primeros del XVII, hasta el esplendor del bel canto, la historia de los tratados de canto europeos se encuentra inseparablemente asociada a las teorías retóricas y filosóficas clásicas, más tarde reinterpretadas por los autores humanistas y preenciclopedistas. Al escribir su Tratado completo del arte del canto, una obra eminentemente práctica, Manuel García hereda esta tradición y contribuye a ella con cada una de las observaciones y ejemplos musicales que propone.
16
Picco, Gabriele, Yanhua Rao, Angham Al Saedi, et al. "Abstract 420: On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells." Cancer Research 85, no. 8_Supplement_1 (2025): 420. https://doi.org/10.1158/1538-7445.am2025-420.
Full textAbstract:
Abstract Werner helicase inhibitors (WRNi) are in clinical development for treating patients with microsatellite-unstable (MSI) tumors characterized by defective DNA mismatch repair. Here, we investigate the impact of cancer cell evolutionary adaptation on WRN pharmacological inhibition with implications for understanding drug selectivity and potential clinical resistance. Coupling genome-wide CRISPR screens with WRN gene knockout, no suppressors of WRN dependency were identified, underscoring WRN’s essential non-redundant function in MSI cells. Pharmacogenomic screens pinpointed modulators of WRNi sensitivity, including SMARCAL1, linking it to WRN-MSI synthetic lethality. Semi-saturation mutagenesis of WRN and prolonged drug treatment identified on-target WRN mutations driving acquired resistance to multiple WRNi in vitro and in vivo. Specific resistance mutations induce cross-resistance to WRN inhibitors, whereas others preserve sensitivity to alternative WRNi. Our work guides next-generation strategies for targeting MSI cancers, enabling cross-resistance studies to evaluate current and novel WRNi efficacy and informing future clinical trial design. Citation Format: Gabriele Picco, Yanhua Rao, Angham Al Saedi, Samantha J. Walker, Shriram Bhosle, Yang Lee, Sara F. Vieira, Gilberto Valdes Garcia, Kieron May, Francesco Sassi, Mamta Sharma, Cansu Dincer, Inigo Barrio Hernandez, Theo Bell, Anastasia Kavasakali, Maria Garcia-Casado, Ray Shenje, Cuthbert Martyr, Edward Brnardic, Nanhua Deng, Hristina Grigorova Dimitrova, Emre Karakoc, Emma Hitch, Katrina McCarten, Zoe Hewitson, Howard Lightfoot, Syd Barthorpe, Michael P. DeMartino, Phil Landis, Emanuel Gonçalves, Andrea Bertotti, Livio Trusolino, Geeta Sharma, Matthew A. Coelho, Jonathan Houseley, Benjamin Schwartz, Mathew J. Garnett. On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 420.
17
Caldas, Rafael Pires Quaresma. "A Associação de Canto Coral e as políticas culturais do Estado Novo (1941-1946)." Revista Música 23, no. 1 (2023): 289–307. http://dx.doi.org/10.11606/rm.v23i1.212237.
Full textAbstract:
Este estudo aborda o surgimento da Associação de Canto Coral durante o Estado Novo, utilizando a abordagem micro-histórica para analisar as conjunturas da época. É sustentado que a Associação recebeu amplo apoio da intelectualidade acadêmica ligada à imprensa. A pesquisa baseia-se nos conceitos de Anderson Benedict e Walter Benjamin ao explorar a documentação relacionada à imprensa. Destaca-se a importância de Cleofe Person de Mattos no cenário artístico coral e na comunidade intelectual, por meio de seus estudos musicológicos ligados ao Pe. José Maurício Nunes Garcia, sendo um exemplo de emancipação feminina no cenário musical brasileiro. Além disso, o estudo demonstra que, a partir do Estado Novo, as políticas governamentais passaram a dar mais atenção à cultura por meio de incentivos ao patrimônio histórico. Percebe-se que o ideal modernista continua presente na abordagem do repertório da Associação de Canto Coral, influenciada pelas práticas do canto orfeônico e pelas abordagens nacionalistas características do movimento modernista. O estudo também destaca as dificuldades de conexão entre as abordagens de tradição sinfônica e o mercado consumidor, a partir do histórico da Associação de Canto Coral.
18
Sormin, Rosmin. "Strategies for counseling the dangers of smoking for health for students." International Journal of Curriculum Development, Teaching and Learning Innovation 2, no. 1 (2023): 34–38. https://doi.org/10.35335/curriculum.v2i1.147.
Full textAbstract:
This activity is a form of application in the Teacher Professional Education Program carried out by teachers throughout Indonesia. Based on the results of surveys, interviews and observations found student problems about the number of students who smoke and also obtained from the background of many families who smoke. Cigarettes not only affect the smoker but also those around the smoker who also get smoke from cigarettes. The high rate of smoking will also have an impact on the high rate of smoking-related diseases. Smoking habits can increase a person's chances of developing several diseases such as heart disease, cancer and lung disease and can even lead to death. Providing counseling to students of class XII IPA 3 SMA Negeri 1 Garoga about the dangers of smoking can reduce students' desire to smoke. The existence of this counseling will form a good attitude and action in maintaining personal health
19
Parada, Humberto, Ilir Agalliu, Daniela Sotres-Alvarez, et al. "Abstract A078: Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): A078. http://dx.doi.org/10.1158/1538-7755.disp24-a078.
Full textAbstract:
Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR015) of the Conference Program/Proceedings. Citation Format: Humberto Parada, Ilir Agalliu, Daniela Sotres-Alvarez, Andrew F. Olshan, Kelly R. Evenson, Thomas E. Rohan, Robert C. Kaplan, Caroline A. Thompson, Linda C. Gallo, Frank J. Penedo, Jianwen Cai, Sylvia Wassertheil-Smoller, Bharat Thyagarajan, Stefani N. Thomas, Olga L. Garcia-Bedoya, Gregory A. Talavera. Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) – The Onco-SOL Ancillary Study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A078.
20
Fuchs, Charles. "Reply to the Letter to the Editor from Garcia-Albeniz and Gallego." Clinical Cancer Research 15, no. 16 (2009): 5288.2–5288. http://dx.doi.org/10.1158/1078-0432.ccr-09-0803.
Full text
21
Pereira, Cláudia da Silva, and Germano Andrade Penalva. "Nem todas querem ser Madonna: representações sociais da mulher carioca, de 50 anos ou mais." Revista Estudos Feministas 22, no. 1 (2014): 173–93. http://dx.doi.org/10.1590/s0104-026x2014000100010.
Full textAbstract:
O objetivo do presente trabalho é refletir sobre as representações sociais da mulher com 50 anos ou mais na cultura midiática. Se, por um lado, a cantora Madonna é celebrada como um dado modelo típico ideal de juventude e corpo para a sua idade, por outro, o que se encontra no discurso das cariocas de 50 anos consideradas "enxutas" nem sempre vai ao encontro desse imaginário social hegemônico e globalizado. Inspirada pelas relações entre as forças do contexto local e da homogeneização global, atuantes na construção simbólica das sociedades moderno-contemporâneas, empreende-se a uma comparação, respectivamente, entre a jovialidade da "garota de Ipanema" e o rejuvenescido "corpo de Madonna". Metodologicamente, a escolha por um estudo antropológico, combinado com a análise do discurso midiático, busca explorar, entre outras questões, o entendimento da expressão "tenho idade, mas não sou velha" ou de como vêm a se autorreferenciar as mulheres rotuladas como "cinquentonas" e, ao mesmo tempo, "ageless". Pretende-se, em suma, discutir o que é "ser jovem" na sociedade contemporânea, dentro da perspectiva de gênero, considerando-se, para tanto, dois modelos construídos a partir de representações locais e globais.
22
Araujo, Denise Castilhos de, and Bianca Lopes. "Feminismo na música: uma análise do videoclipe "Run The World (Girls)", de Beyoncé." Revista Ártemis 24, no. 1 (2018): 179. http://dx.doi.org/10.22478/ufpb.1807-8214.2017v24n1.31612.
Full textAbstract:
Este artigo discute a presença de signos visuais que remetem ao feminismo, no videoclipe “Run The World (Girls)”, da cantora Beyoncé. Para tanto, discute-se a história da mulher, a imagem como forma de linguagem, o surgimento do videoclipe e a carreira de Beyoncé. Os métodos de pesquisa utilizados neste estudo são documental e bibliográfico, e a observação e análise de um documentário da cantora, bem como de um videoclipe que é objeto deste estudo. Para discorrer sobre a história da mulher, utiiza-se Alves e Pitanguy (1985), Robles (2006) e Sarti (2004), para falar sobre os tipos de feminismo, Heywood (2010), Nye (1998), Nicholson (2010) e Garcia e Miranda (2012). Com o intuito de discutir a imagem como forma de linguagem, utiliza-se Dondis (1997), Aumont (1993) e Deleuze (1983). A análise é baseada na semiótica de Joly (1996) e Santaella (1983), com auxílio de Chevalier (1999), Mondro (2008) e Farina (2006). Através da análise de imagem das figuras do videoclipe foi possível identificar signos utilizados por Beyoncé para discutir feminismo com o público.
23
Campos, Melissa Oliveira Cavalcante. "BELCHIOR E A CRÍTICA POLÍTICA NA CANÇÃO “MEU CORDIAL BRASILEIRO”." REVISTA FOCO 16, no. 8 (2023): e2705. http://dx.doi.org/10.54751/revistafoco.v16n8-102.
Full textAbstract:
O presente artigo analisa a crítica política na canção “Meu cordial brasileiro”, do cantor e compositor cearense Belchior. Primeiro, abordamos a relação da música com o contexto ditatorial no Brasil. Em seguida, investigamos a trajetória de Belchior através de estudos sobre ele - desde o nascimento em Sobral, a vivência em Fortaleza fazendo parte da geração de artistas e intelectuais conhecida como Pessoal do Ceará, e em outros locais do Brasil - e constatamos que o artista foi censurado e que compôs letras que continham críticas ao regime. Para analisar a letra da música “Meu cordial brasileiro”, nos baseamos no diálogo das obras de autores sobre análise do discurso e linguística, dentre eles, Garcia, Menezes, Fiorin, Maingueneau e Koch, utilizando os termos “metáfora”, “intertextualidade” e “ironia”. Na análise, identificamos elementos argumentativos e textuais que nos permitem verificar como esta canção contesta o regime político. O estudo ampliou um pouco o conhecimento da nossa história artística, cultural e política.
24
Luque Moya, Gloria. "El desgarrador canto a la muerte. Análisis filosófico de la obra de Federico García Lorca." Claridades. Revista de Filosofía 12, no. 1 (2020): 307. http://dx.doi.org/10.24310/claridadescrf.v12i1.6816.
Full textAbstract:
La muerte es un asunto central en la obra de Federico García Lorca, que llego a convertirse en una obsesión que impregnó su bibliografía al completo. Este tema, común entre otros poetas y escritores de la época, adquiere un tamiz especial de la mano del literato que afronta y reflexiona sobre la misma a través de sus poemas y piezas teatrales. Este artículo plantea un análisis filosófico sobre la muerte en las páginas de Lorca, haciendo un recorrido por las principales obras dedicadas a este tema. Para ello, en primer lugar, se muestra la posición de Lorca ante la muerte y su forma de tratarla. Después, se analizará la visión de la muerte en sus poemas y piezas teatrales. A modo de conclusión, me gustaría destacar cómo la obra del poeta no considera la muerte desde una perspectiva trágica de la vida sino desde una filosofía de la creación.
25
Conejo-Garcia, Jose R. "Abstract IA06: Isotype-Switched Antibodies Produced in Tertiary Lymphoid Structures Antagonize Human Cancer Progression." Cancer Immunology Research 13, no. 2_Supplement (2025): IA06. https://doi.org/10.1158/2326-6074.io2025-ia06.
Full textAbstract:
Abstract Many epithelial cancers orchestrate prognostically significant intra-tumoral tertiary lymphoid structures (TLS), yet the mechanisms behind their antitumor activity remain unclear. Here we show that intra-tumoral TLS in human cancers contain highly oligoclonal B cells and plasma cells expressing IgA or IgG, which are not found outside the TLS. We demonstrate that these antibodies antagonize the progression of the autologous tumor. Accordingly, TLS enlargement and de novo formation in response to the injection of an oncolytic virus in muscle-invasive, cisplatin-ineligible bladder cancers is associated with complete clincial responses and the production of IgA and IgG antibodies at tumor beds. Our data show that TLS inhibit malignant progression through in situ production of isotype-switched anti-tumor antibodies , underscoring the importance of coordinated cellular and humoral responses in human cancer. Citation Format: Jose R Conejo-Garcia. Isotype-Switched Antibodies Produced in Tertiary Lymphoid Structures Antagonize Human Cancer Progression [abstract]. In: Proceedings of the AACR IO Conference: Discovery and Innovation in Cancer Immunology: Revolutionizing Treatment through Immunotherapy; 2025 Feb 23-26; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Immunol Res 2025;13(2 Suppl):Abstract nr IA06.
26
Valencia-Espinoza, Evelyn, Emiliano Pulla-Cadmilema, Lissette P. Velez Avila, et al. "Abstract P4-07-08: IMPACT ON OVERALL SURVIVAL ACCORDING TO BREAST CANCER IMMUNOPHENOTYPES: REAL-WORLD DATA IN METASTATIC BREAST CANCER IN ECUADOR." Cancer Research 83, no. 5_Supplement (2023): P4–07–08—P4–07–08. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-07-08.
Full textAbstract:
Abstract Background: Breast cancer immunohistochemistry subtype classification by hormone receptor has become the standard practice for therapeutic decision making. The subtype is one of the crucial factors affecting breast cancer prognostic. Despite the progress in understanding of complex mechanisms in progression of breast cancer, the treatment is a global challenge health around the world, the 5-year survival rate is 26%. Currently in develop countries, in the metastatic stage, a gain in survival in the HR+/HER2+ subtype has been evidenced, likely attributable to major advances in HER2-targeted treatment (1). However, although in developed countries there is access to targeted therapy, in the Ecuadorian health system, difficulties complicate patients access to health care and treatment. Methods: We conducted a retrospective study about survival data in breast cancer metastatic according immunohistochemistry subtype. We analyzed all primary invasive breast cancer cases in the period from 2016 to 2020 in an oncology institute of Ecuador, the final study sample consisted for 83 patients. The overall survival was calculated by the Kaplan-Meier method and compared by the long-rank test. Multivariable adjusted hazard ratios (HR) were estimated by Cox regression models. Results: There were 31 patients (37.1%) with a HR(+)/HER2(-) breast cancer subtype, 15 patients HR(+)/HER2(+), 5 patients HER2 (+),18 patients HR(-)/HER2(-) and 14 patients without breast cancer subtype identified. Most patients were treated with different chemotherapy protocols; additional, in the group of women with HR(+)/HER2(+) subtype and HER2 (+) subtype only 15.87% were treated with HER2-targeted treatment, the vast majority in the last year. The best survival pattern was observed among women with HR(+)/HER2(-) breast cancer subtype with 35 months (IC 95% = 14,9 – 55), followed by HR(+)/HER2(+) with 27 months (IC 95% = 13,21 – 40,79), HER2 with 24 months (IC 95% = 4.4 – 32), and 14 months (IC 95% = 0 – 29.7) for HR(-)/HER2(-), however the difference wasn’t significant (p = 0.08). Hazard ratio of HR(+)/HER2(-) breast cancer subtype for breast cancer specific mortality risk was 1.61 (IC 95% = 0.64 – 4.19 p = 0.29). Conclusions: Hormone receptor subtype wasn’t s a significant independent prognostic factor in female metastatic breast cancer patients in a single center of Ecuador. However, there is a trend that subtype HR(+)/HER2(-) breast cancer subtype, has a better survival than the rest of the subtypes. These results differ from those of the rest of the world, probably access to target medicine and difficulties in access to health care system are the cause. Thus, better strategies for early access to adequate chemotherapy protocols should be developed Citation Format: Evelyn Valencia-Espinoza, Emiliano Pulla-Cadmilema, Lissette P. Velez Avila, Lissette Yagual Bohorquez, Maria del Mar Sanchez Salazar, Patricia Tamayo Aguilar, Jimmy Martin-Delgado, Glenda Ramos Martinez, Katherine Garcia Matamoros, Roberto Escala Cornejo, Felipe Campoverde Merchan, Ruth Engracia Vivanco, Mayra Santacruz Maridueña, Isabel Delgado Guerrero, Veronica Torres Floril, Diego Garcia Gamboa, Elina A. Rodriguez-Melendez. IMPACT ON OVERALL SURVIVAL ACCORDING TO BREAST CANCER IMMUNOPHENOTYPES: REAL-WORLD DATA IN METASTATIC BREAST CANCER IN ECUADOR [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-07-08.
27
Villa-Guillen, Diana Evelyn, Aurelio A. Mata-Valenzuela, Hector Tecuanhuey-Tlahuel, et al. "Abstract 4855: Identifying hot spots of breast cancer and industrialized areas in Hermosillo, Sonora, Mexico." Cancer Research 84, no. 6_Supplement (2024): 4855. http://dx.doi.org/10.1158/1538-7445.am2024-4855.
Full textAbstract:
Abstract Background: Sonora, a state in Mexico, has the highest rates of breast cancer in the country and has a history of industrial pollution. These factors may contribute to an increased risk of breast cancer. Hermosillo, the state capital, exhibits both of these characteristics. Given these conditions, it is important to further evaluate the prevalence of breast cancer hotspots and the potential links between breast cancer and industrialized areas. Objective: Identify breast cancer hot spots and their association to industrialized areas in Hermosillo, Sonora, Mexico. Methods: This study collected clinical data on breast cancer cases (current, survivors, deceased) from hospital files in Hermosillo that were 10 years old. The primary unit of analysis was neighborhoods. The study estimated breast cancer prevalence by analyzing the number of females per neighborhood, based on data reported by INEGI Census 2020. The data was categorized by age groups (age group no. 1 of 18 to 59 years old, no. 2 of 60 to 64 years old, and no. 3 of 65 years old or older). The estimated prevalence was depicted on a map using ArcGIS software, version 10.8.2. Hot spot analysis was used to identify neighborhoods with high breast cancer prevalence. The study also categorized neighborhoods as industrialized areas if they contained at least six hazard-generator industries. Results: A total of 1394 cases of breast cancer were gathered from hospitals. Location information for 3697 industries was provided by INEGI. Out of the 756 neighborhoods studied, 95 (12.6 %) were found to be industrialized areas, while 661 (87.4 %) were non-industrialized. Four neighborhoods in Hermosillo's southeast were observed to have breast cancer hot spots (unadjusted). After adjusting for age, one hot spot was found in the southeast for age group no. 1 (one neighborhood), while hot spots for group no. 2 (three neighborhoods) and no. 3 (33 neighborhoods) were in Hermosillo's northwest. The hot spots were related to industrialized areas (unadjusted OR = 6.94, 95% CI (0.94, 50.8), p-value = 0.05). After age adjustment, this association was statistically significant for group no. 3 (OR = 2.70, 95% CI (1.27, 5.72), p-value = 0.009), but not for group no. 1 (OR = 1.69, 95% CI (0.06, 41.74), p-value = 0.748) or group no. 2 (OR = 2.56, 95% CI (0.23, 28.46), p-value = 0.44). Conclusions: Our research found a link between industrialized areas and high breast cancer rates. We also found hotspots for women aged 65+ in Hermosillo, with 33 affected neighborhoods in the city's northwest. This is the first comprehensive study examining breast cancer prevalence in Hermosillo over a ten-year period. More extensive studies are needed in other cities in Sonora, Mexico, to confirm our findings. Citation Format: Diana Evelyn Villa-Guillen, Aurelio A. Mata-Valenzuela, Hector Tecuanhuey-Tlahuel, Andres M. Galvez-Arevalo, Kenneth L. Garcia-Castellon, Yoahana E. Guzman-Hernandez, Karla S. Ortega-Landa, Fatima Y. Pelayo-Rodriguez, Jose R. Silva-Rivera, Rogelio A. Ureña-Acosta, David O. Garcia, Jorge A. Villa-Carrillo. Identifying hot spots of breast cancer and industrialized areas in Hermosillo, Sonora, Mexico [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4855.
28
Yemele, Didiane, Leïla Djamilatou, Benjamin Talom, et al. "Microbiological Profile of Vaginal Swabs from Infertile Women in the Cities of Ngaoundere and Garoua, Cameroon." Central African Journal of Public Health 10, no. 6 (2024): 242–56. https://doi.org/10.11648/j.cajph.20241006.13.
Full textAbstract:
Genital infections are a real public health problem in developed countries. They have serious consequences such as ectopic pregnancy (EP), chronic pelvic pain, premature delivery, miscarriage, cervical cancer and even infertility. The objective of this study was to determine the epidemiological and microbiological profile of genital infections among infertile women in the cities of Ngaoundéré and Garoua. This descriptive study was carried out in the Protestant and regional hospitals, as well as the military and regional hospitals serving the cities of Ngaoundéré and Garoua, over a period of five months, from August 2020 to January 2021. Women of reproductive age (15 to 45 years) who met the inclusion criteria, gave their informed consent, and had at least one consultation in the gynecology department of the aforementioned hospitals for infertility made up our population. Thus, the study included 100 women, or 50 women per city. A pre-tested questionnaire was employed to get data from the subjects. Blood samples were taken for chlamydia testing, and cervical-vaginal samples were taken for microbiological analysis (PCV+ATB and mycoplasma testing). The gathered information. SphinxPlus. V5 was the program used to analyze the data that were collected. Ninety-six percent of the 100 women who participated in this study had a vaginal infection. The infertile women's modal age range was 26–35 years old, with a mean age of 29. Of the women, 54% were housewives, 33% had completed their elementary; education, and 55 were in monogamous marriages. At 65%, secondary infertility was the most prevalent type. 5.15 years was the average length of infertility. Abortions accounted for 41% of the patients' histories, whereas genital infections made up 69%. When the infertile women's vaginal pH was analyzed, the majority (69%) had a pH > 4.5. Chlamydia trachomatis (28.41%), Ureaplasma urealyticum (22.63%), Candidas albicans (20.58%), Gardnerella vaginalis (14.40%), Mycoplasma hominis (9.46%), Candidas spp (1.65%), Staphylococcus (1.64%), Trichomonas vaginalis (0.82%), and Neisseria gonorrhoeae (0.41%) were among the microbiological analyses of the samples. The etiological identification of genital infections and infertility of infectious or tubal origin, which can be avoided with early intervention, is greatly aided by microbiology.
29
Binagwaho, Agnes, Patricia J. Garcia, Babacar Gueye, et al. "Eliminating Deaths From Cervical Cancer—Report of a Panel at the 7th Annual Symposium on Global Cancer Research, a Satellite Meeting at the Consortium of Universities for Global Health 10th Annual Meeting." Journal of Global Oncology, no. 5 (December 2019): 1–7. http://dx.doi.org/10.1200/jgo.19.00287.
Full textAbstract:
This is a summary of the presentations addressing approaches and achievements to reach the goal of eliminating cervical cancer as a global public health problem that were delivered at the 7th Annual Symposium on Global Cancer Research at the 10th Annual Consortium of Universities for Global Health Meeting in March 2019. Dr Princess Nothemba Simelela, Assistant Director-General for Family, Women, Children and Adolescents, World Health Organization, gave an introduction to the World Health Organization–led Cervical Cancer Elimination Initiative and the emerging conceptual framework and targets that will shape the global 2020 to 2030 strategy. Subsequent presentations shared experiences from national programs in Rwanda (Agnes Binagwaho), Latin America (Patricia J. Garcia), and Senegal (Babacar Gueye and J. Andrew Dykens. Successes in intensified human papillomavirus vaccination and screening with follow-up treatment of early and advanced lesions detected are highlighted as well as the challenges and obstacles in achieving and maintaining high coverage in Africa and Latin America. With strong political leadership, commitment of national stakeholders, and the use of proven and cost-effective approaches to human papillomavirus vaccination, screening, and treatment, the vision of a world free of cervical cancer and saving women’s lives every year by preventing deaths from cervical cancer will be achievable in the next generation in all countries.
30
Wen, Ru, G. Edward Wen, Zhengyuan Qiu, et al. "Abstract 3007: AZGP1 inhibits angiogenesis in prostate cancer." Cancer Research 84, no. 6_Supplement (2024): 3007. http://dx.doi.org/10.1158/1538-7445.am2024-3007.
Full textAbstract:
Abstract AZGP1 is involved in various biological processes, including lipid metabolism, regulation of cell proliferation, migration and invasion, and immune response. The loss of AZGP1 is associated with worse clinical outcomes, and AZGP1 has been indicated as a potential biomarker for prostate cancer. However, the underlying mechanisms of AZGP1 function in prostate cancer are unknown. This study reports AZGP1's pivotal involvement in angiogenesis within the prostate cancer tumor environment. Neither knockout nor overexpression of AZGP1 affects in vitro prostate cancer cell proliferation, migration, or invasion. Morphologically, AZGP1-deficient mouse prostates appear normal, but exhibit increased fibroblast growth in periglandular stroma after 6 months. The overexpression of AZGP1 does not impact the growth of PC3 and DU145 tumors; instead, these tumors significantly reduced microvessel density, suggesting AZGP1 exhibits anti-angiogenic properties. Proteomic profiling shows distinct profile of angiogenesis-related proteins between PC3-AZGP1-OV and PC3 control cells, featuring proteins like PDCD6 and MMP9. This study provides insights into the anti-angiogenic attributes of AZGP1 in prostate cancer, underscoring its potential as a therapeutic target for prostate cancer. Citation Format: Ru Wen, G Edward Wen, Zhengyuan Qiu, Eric E Peterson, Fernando Jose Garcia Marques, Abel Bermudez, Jonathan R Pollack, Hongjuan Zhao, Sharon Pitteri, James Brooks. AZGP1 inhibits angiogenesis in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3007.
31
Martelli, Valentino, Joana Vidal, Maria Concepción Fernández-Rodríguez, et al. "Abstract B038: Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study." Clinical Cancer Research 30, no. 21_Supplement (2024): B038. http://dx.doi.org/10.1158/1557-3265.liqbiop24-b038.
Full textAbstract:
Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR009) of the Conference Program/Proceedings. Citation Format: Valentino Martelli, Joana Vidal, Maria Concepción Fernández-Rodríguez, Pilar García-Alfonso, David Páez, Joan Gibert, Jennifer Linares, Annarita Sibilio, Vicente Alonso, Maria Teresa Cano, Cristina Santos, Gema Duran, Elena Élez, José Luis Manzano, Rocio Garcia-Carbonero, Reyes Ferreiro, Ferran Losa, Estela Pineda, Javier Sastre, Auxiliadora Gomez-España, Rodrigo Toledo, Fernando Rivera, Beatriz Bellosillo, Josep Tabernero, Ramon Ramon Salazar, Enrique Aranda, Clara Montagut. Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study [abstract]. In: Proceedings of the AACR Special Conference: Liquid Biopsy: From Discovery to Clinical Implementation; 2024 Nov 13-16; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(21_Suppl):Abstract nr B038.
32
Salmeron, Julia, Natalia Castrejón-de-Anta, Pilar Guerra-Garcia, et al. "Abstract 2502: Unravelling the heterogenous molecular landscape of pediatric post-transplant lymphoproliferative disorders." Cancer Research 82, no. 12_Supplement (2022): 2502. http://dx.doi.org/10.1158/1538-7445.am2022-2502.
Full textAbstract:
Abstract The genetic landscape of post-transplant lymphoproliferative disorders (PTLD) in pediatric population has not been fully elucidated. This absence of information raises the question whether therapeutic strategies should be the same as for their counterparts in immunocompetent (IC) patients. The aim of this study was to characterize genetically and immunophenotypically pediatric monomorphic PTLD. Thirty-nine monomorphic PTLD ≤19 years-old (mean 10y, gender 25 male/14 female) were recruited and analyzed for germinal center markers, IRF4 and EBER expression. Presence of MYC, PAX5, IRF4, BCL2, BCL6 and 11q alterations was investigated by FISH. Additional molecular studies included clonality, copy number (CN) arrays, cell of origin-COO (Nanostring) and mutational analyses (Custom 167 lymphoma related genes panel, SureSelectXT, Agilent). Twenty-nine patients received solid organ transplantation and eight were hematopoietic stem cell transplant recipients. The mean time from transplant to PTLD diagnosis was 34 months (range 2-170) and the estimated 5-year overall survival (5y-OS) rate was 67%. Patients that received a solid organ had a better prognosis than hematopoietic stem cell transplant recipients (5y-OS 83% vs. 38%, p=0.03). Thirty-three cases were classified as diffuse large B-cell lymphoma (DLBCL) and six as Burkitt lymphoma (BL). Thirty-two cases had extranodal localization, 21 of which in the gastrointestinal tract. Among the DLBCL, 24/28 cases had an ABC/non-GC COO phenotype and the six BL were GCB. EBER was positive in 33/37 cases. Five out of six BL and one DLBCL had MYC rearrangements, while no 11q alterations or other rearrangements were observed. Ten out of the 23 pediatric monomorphic PTLD studied displayed CN alterations (mean 1.6 alt/case; range 0-12). Comparative analyses showed that pediatric PTLD had lower genetic complexity than BL (Scholtysik, 2010) and DLBCL (Ramis-Zaldivar, 2020) in IC patients and adult-PTLD (Ferreiro, 2016; Rinaldi, 2010) and lacked characteristic CN alterations of those groups. Regarding the mutational profile, all 6 PTLD-BL carried MYC mutations in addition to ID3 (4 cases), ARID1A (2 cases) or CCND3 (1 case) and a higher mutational burden than PTLD-DLBCL (12.3 vs 6.2, p=0.01). PTLD-DLBCL showed a very heterogeneous profile characterized by a lower number of mutations than their counterparts in IC patients (2.4 vs 6.5, p=0.01). Pathway enrichment analysis revealed that epigenetic modifiers and NOTCH pathway (4 cases each) were the most recurrently affected. Two out of 20 cases were classified as N1 according to LymphGen (Wright, 2020) algorithm while the rest remained undetermined. The mutational profile of pediatric PTLD-BL is similar to that observed in IC patients whereas PTLD-DLBCL are less complex than their counterpart in IC children and present a very heterogeneous mutational landscape with enrichment in NOTCH pathway mutations. Citation Format: Julia Salmeron, Natalia Castrejón-de-Anta, Pilar Guerra-Garcia, Joan Enric Ramis-Zaldivar, Mónica López-Guerra, Dolors Colomer, Francisco Diaz-Crespo, Marta Garrido, Javier Menarguez, Maria del Mar Andrés, Eugenia Garcia-Fernandez, Margarita Llavador, Noelia Garcia, Blanca Gonzalez-Farré, Idoia Martin-Guerrero, Carmen Garrido, Itziar Astigarraga, Alba Fernández, Jaime Verdú-Amorós, Soledad González-Muñíz, Berta Gonzalez, Verónica Celis, Elias Campo, Olga Balagué, Itziar Salaverria. Unravelling the heterogenous molecular landscape of pediatric post-transplant lymphoproliferative disorders [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2502.
33
Moreira, Igor Lemos. "PARTICIPAÇÃO DE ARTISTAS LATINOS NO CASO ELIÁN GONZÁLEZ." Revista Latino-Americana de História- UNISINOS 11, no. 28 (2022): 232–51. http://dx.doi.org/10.4013/rlah.2022.1128.15.
Full textAbstract:
O caso Elián González (1999) figura como um dos principais marcos na história das relações políticas entre Cuba e Estados Unidos. Não se tratando de um caso único de discussão diplomática entre os dois países a respeito do exílio e das migrações, o processo de Elián foi amplamente coberto pela mídia estadunidense e global em função da mobilização de exilados anticastristas que exigiam a permanência do jovem em Miami. Parte destas mobilizações ocorreram junto a participação e apoio de artistas latinos, em com destaque aos cubanos exilados, nesse movimento a exemplo de Andy Garcia e Gloria Estefan. Este artigo, inserido nos debates da História do Tempo Presente, em interface com a História Cultural, analisa o engajamento social, política e cultural destes artistas, em especial da cantora Gloria Estefan, que participaram de manifestações coletivas na cidade de Miami durante o julgamento do caso Elián González, a partir de registos midiáticos.
34
Garcia-Santillan, Ailen, Jessanne Y. Lichtenberg, He Shen, et al. "Abstract 4280: Regulatory T cells contribute to tumor cell dissemination by extracellular matrix remodeling." Cancer Research 84, no. 6_Supplement (2024): 4280. http://dx.doi.org/10.1158/1538-7445.am2024-4280.
Full textAbstract:
Abstract Regulatory T (Treg) cells function to enforce peripheral tolerance and are potent suppressors of tumor immunity. In breast cancer, we have shown that Treg cells promote tumor growth by favoring alternative activation of macrophages via suppression of IFN-γ. The tumor-associated extracellular matrix (ECM) is a key regulator of metastatic dissemination and is emerging as a critical regulator of tumor immunity. However, the reciprocal effects of the immune system on the ECM remain elusive. Using murine in vivo, ex vivo and bioengineering models we describe Treg cell-dependent changes in the tumor ECM that facilitate tumor cell movement and metastatic dissemination. Further, Treg cell-dependent matrisome signatures correlate with survival in human breast cancer samples. This work underscores a previously unrecognized role of Treg cells on the ECM that facilitates metastasis and is consistent with tissue Treg cell emergent function as critical regulators of tissue repair and cancer. Citation Format: Ailen Garcia-Santillan, Jessanne Y. Lichtenberg, He Shen, Mikhail G. Dozmorov, Amy L. Olex, Priscilla Y. Hwang, Paula D. Bos. Regulatory T cells contribute to tumor cell dissemination by extracellular matrix remodeling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4280.
35
Essiben, Félix, Inna Rakya, Aoudi Mbarjuk, et al. "Management of Breast Cancer in a Resource-Limited Semi-Urban Setting: A Series of 155 Cases Treated in Garoua, Cameroon." Open Journal of Obstetrics and Gynecology 15, no. 03 (2025): 408–22. https://doi.org/10.4236/ojog.2025.153036.
Full text
36
Tailor, Dhanir, Arpit Dheeraj, Fernando Jose Garcia-Marques, et al. "Abstract 1799: Inhibition of triple negative breast cancer metastasis via Enolase-1 modulation." Cancer Research 82, no. 12_Supplement (2022): 1799. http://dx.doi.org/10.1158/1538-7445.am2022-1799.
Full textAbstract:
Abstract Triple-negative breast cancer (TNBC) is one of the aggressive forms of breast cancer and frequently relapses and metastases. Currently, very few options are available for TNBC treatment. Cancer cells exploit glycolytic machinery for the Warburg effect and aerobic glycolysis. Enolase 1 (ENO1) is the glycolytic enzyme expressed in the majority of tissues and many cancer cells have its higher expression. Apart from the glycolytic role in the cytosol, ENO1 also plays different roles in cancer cells including function as a surface receptor. We have developed a chemical small molecule (CET12) that strongly binds to ENO1 and restrain its activity and subcellular localization. CET12 treatment arrests the TNBC cells in the mitotic phase and leads the apoptotic cell death via AMPK activation. Global proteome profiling suggested that CET12 pushes the cells toward oxidative phosphorylation. It also inhibits cell migration and invasion in vitro. In vivo studies using 4T1 and EMT6 syngeneic mouse models are also in-line with in vitro results and revealed that SU0212 treatment inhibits tumor progression and metastasis. These results were further supported by tail vain lung metastasis assay and intracardiac injection mouse model. This study provides compelling preclinical data for further development of CET12 for the treatment of TNBC. Citation Format: Dhanir Tailor, Arpit Dheeraj, Fernando Jose Garcia-Marques, Mallesh Pandrala, Abel Bermudez, Sharon Pitteri, Sanjay V. Malhotra. Inhibition of triple negative breast cancer metastasis via Enolase-1 modulation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1799.
37
Alves, Cristiane da Silva. "mulheres velhas (r)existem: algumas notas sobre a velhice feminina e sua presença na literatura brasileira do início do século XXI." Anuário de Literatura 26 (October 26, 2021): 01–15. http://dx.doi.org/10.5007/2175-7917.2021.e78526.
Full textAbstract:
A partir do estudo de narrativas ficcionais da literatura brasileira publicadas nas primeiras décadas deste novo século, tem-se por objetivo investigar a presença das mulheres velhas, especialmente aquelas que se destacam como narradoras e/ou como protagonistas. Pretende-se observar se e como a literatura contemporânea tem contribuído para forjar determinadas identidades, ou antes, para reforçar ou (des)construir padrões e papéis comumente atribuídos à figura feminina envelhecida. Busca-se, sobretudo, contribuir para afastar ou minimizar os estereótipos e o silenciamento acerca da velhice feminina (ainda) presentes em nosso cânone. Para tanto, são tomados como corpus os romances Mar azul (Rocco, 2012), de Paloma Vidal; Amor em dois tempos (Companhia das Letras, 2014), de Lívia Garcia-Roza; Quarenta dias (Alfaguara, 2014) e Outros Cantos (Alfaguara, 2016), ambos de Maria Valéria Rezende. Para dar suporte às análises, recorre-se às contribuições de Simone de Beauvoir, Guita Grin Debert, Mirian Goldenberg, Ecléa Bosi e Regina Dalcastagnè, entre outros.
38
García Flores, Alejandro, Rafael Monroy Martínez, and José Manuel Pino Moreno. "Ethnozoological study of wild vertebrates of the Bonifacio Garcia community, Morelos, Mexico." Revista Peruana de Biología 27, no. 3 (2020): 361–74. http://dx.doi.org/10.15381/rpb.v27i3.17080.
Full textAbstract:
The aim of this study was to analyze the ethnozoological knowledge that the inhabitants of the Bonifacio García community, Morelos, Mexico, conserve about wild vertebrate. Semi-structured interviews were applied to 30 key informants, through participant observation and guided tours, traces such as footprints, excreta, burrows and pelts and in vivo observation were researched for the identification of the mentioned species and the following indexes were calculated: value of diversity of use for each species (VDS) and of medicinal uses (DVM), as well as the diversity index of the treated diseases (DITD). The study recorded a total of 42 wild vertebrate species, of these 28 are used: mammals 39.3%, birds 32%, reptiles 18%, fish 7.1% and amphibia 3.6%. The main use values were alimentary (0.54), medicinal (0.46) and ornamental (0.43). The white-tailed deer, the black iguana and the rattlesnake registered 0.57 of VDS and a DVM of 0.19. The main diseases treated are cancer, respiratory and skin diseases and rheumatism with an DITD of 0.17. The animals are obtained by means of subsistence hunting in the fields (50%), croplands (43%) and backyards (7%), using most frequently shotguns as arms for capture. We conclude that the appropriation of vertebrates complements basic needs for food and health; therefore, ethnozoological knowledge must be integrated into public policies that enable the conservation and management of wild fauna in the community.
39
Chung, Charlie, Elif Ozcelik, Jill Habel, et al. "Abstract 6678: Microbial regulation of anti-tumor immunity in colorectal cancer." Cancer Research 84, no. 6_Supplement (2024): 6678. http://dx.doi.org/10.1158/1538-7445.am2024-6678.
Full textAbstract:
Abstract Colorectal cancer (CRC) is the 3rd leading site of cancers and cause of cancer cell death. Although Immunotherapies revolutionized cancer therapy, the majority of CRC patients, particularly with metastatic disease, do not respond to the treatments. This necessitates a better mechanistic understanding of the tumor-immune cell interactions in the context of CRC. Microbiome influences multiple biological aspects of the host including immune responses against cancers. Here, we show that the gut microbiome influences cancer MHC-I and -II expression levels and restricts tumor progression and metastasis, resulting in longer survival in 3 different CRC models and two different mouse strains. We found that the anti-tumor effects are dependent on T cells and B cells. Interestingly, depletion of B cell negated anti-metastatic effects of gut microbiome. Mechanistically, MHC-II expression in cancer cells mediates the anti-tumor effects of the microbiome. MHC-II upregulation on human CRC organoids enhances cancer-immune cell interactions and associated apoptosis, demonstrating an anti-tumor role and significance of MHC-II in human CRC. Thus, gut microbes that enhance MHC-II antigen presentation promotes anti-tumor immunity and may be utilized to enhance efficacy of immunotherapy in metastatic CRC. Citation Format: Charlie Chung, Elif Ozcelik, Jill Habel, Jialin Zhang, Yihan Qin, Libia Garcia, Joseph Merrill, Taemoon Chung, Scott Lyons, Zeli Shen, James G. Fox, Peter Westcott, Semir Beyaz. Microbial regulation of anti-tumor immunity in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6678.
40
Windsor. "Colorectal Cancer: Fast Facts. I. Taylor, S. Goldberg and J. Garcia-Aguilar. 1999. Health Press." Colorectal Disease 2, no. 1 (2000): 56. http://dx.doi.org/10.1046/j.1463-1318.2000.00101.x.
Full text
41
Ginori Lozano, Salvador. "Los cantantes castrados y la línea vocal de Mozart. La percepción belcantista de Mozart a inicios del siglo XX según Herman Klein de acuerdo con la vocalidad propuesta por Manuel García." Ciencia Latina Revista Científica Multidisciplinar 9, no. 1 (2025): 4130–59. https://doi.org/10.37811/cl_rcm.v9i1.16138.
Full textAbstract:
El presente trabajo contiene el resultado de una investigación documental sobre la estética del canto de los maestros castrados del siglo XVIII, los métodos de canto del siglo XIX y los inicios del siglo XX. Se considera que el modelo vocal belcantista iniciado por los cantantes castrados es universal y no se limita a los autores italianos de la primera mitad del siglo XIX, por el contrario, está presente en la producción vocal de los compositores que se trabajaron directamente con ellos. La cantidad de obras que compuso Wolfgang A. Mozart directamente para cantantes castrados permite valorar la capacidad musical y vocal de estos cantantes, y más aún, permite considerar que muchos de sus preceptos en la técnica vocal podrían considerarse fundamentales en la actualidad. Esta tradición belcantista de los cantantes castrados pasada por el filtro de un estilo de composición instrumental aplicada al canto parece ser heredada a Manuel Patricio García por su padre, Manuel del Popolo. La percepción de este fenómeno por un experto en el canto, Herman Klein, sufre también las influencias de las corrientes de su tiempo.
42
Hajinajaf, Saeedeh, Hossein Shirvani, Mehdi Roozbahani, and Alireza Khademi. "The effectiveness of moderate intensity continuous exercises and nano-curcumin supplementation on sensory-motor disorders in Rats with brain tumors." Jundishapur journal of Medical Sciences 21, no. 6 (2023): 894–909. http://dx.doi.org/10.32598/jsmj.21.6.2825.
Full textAbstract:
Background and Objectives:Any abnormal growth of cells in the brain in an uncontrolled manner leads to the formation of tumor cell masses and disruption of the normal functional functions of the brain, including sensory-motor problems. The aim of the present study was to evaluate the The effectiveness of moderate-intensity continuous exercise and nanocurcumin supplementation on sensorimotor disorders in mice with brain tumors. Subjects and Methods: 35 healthy male Wistar rats randomly divided into 7 groups of 5, basal control (BC), 4-week control (4wC), basal cancer control(BT), 4-week cancer control(4wT), cancer-training (TE), cancer - Nanocurcumin (TN), Cancer-Exercise-Nanocurcumin (TEN) were divided. One week after the injection of cancer cells in the frontal cortex, the animals entered the main exercise program on the tape by performing the 6-parameter behavioral test (18 points) of Garcia and gavage of nano curcumin supplement at the rate of 80 mg/kg (28 days, 5 days a week). (4 weeks, at a speed of 18 meters per minute, 25-40 minutes and 3 days a week). At the end, rats were victim and data were collected and analyzed. Result: Continuous exercises with moderate intensity Simultaneously with nano-curcumin supplementation significantly reduced tumor volume in the TEN group (p≤0.05). It also led to a significant increase in behavioral testing in the study groups compared to the 4 wT group. Conclusion: It seems that the combination of continuous exercises with nano curcumin can be used as a therapeutic supplement along with other methods to reduce brain tumor size and improve sensory-motor functions.
43
Broome, Larry E., Hakim Bouamar, Kate Lathrop, et al. "Abstract P1-10-06: Effect of aging and mTOR inhibition on human mammary stem cells and early breast cancer progression markers." Cancer Research 82, no. 4_Supplement (2022): P1–10–06—P1–10–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-10-06.
Full textAbstract:
Abstract Ductal carcinoma in situ (DCIS) is the most common form of breast cancer and is a predecessor to invasive carcinoma development. The origins for early breast cancer have been attributed to aberrant single cells, which may include adult stem and progenitor cells. We performed a window trial with mTOR inhibitor sirolimus in patients with atypical ductal hyperplasia (ADH) or DCIS and investigated the epithelial populations in adjacent normal and ADH/DCIS breast tissues along with their residing stem and progenitor cell activity. Differences associated with age, menopausal status, and treatment by sirolimus have also been explored. While the mammary epithelial populations were seen to be unchanged in aging, we found that age correlates with a decline in stem cell activity. mTOR inhibition was also able to abrogate mammary stem cell activity and decrease luminal progenitor passaging lifespan, particularly in postmenopausal patients. While mTOR inhibition had no effect on myoepithelial populations, it did decrease premenopausal luminal cell populations and reduced prognostic markers associated with breast cancer progression from DCIS to invasive breast cancer. These markers include p16INK4A, COX-2, and Ki67, which were reduced in DCIS breast tissue from patients administered with sirolimus as shown through quantitative analysis of immunohistochemistry. Overall, these findings indicate a link from mTOR signaling to mammary stem cell activity and cancer progression. mTOR inhibitors may have potential for breast cancer prevention. Citation Format: Larry E Broome, Hakim Bouamar, Kate Lathrop, Ismail Jatoi, Andrew Brenner, Michael Garcia, Alia Nazarullah, Karla Moncada, Virginia Kaklamani, Lu-Zhe Sun. Effect of aging and mTOR inhibition on human mammary stem cells and early breast cancer progression markers [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-10-06.
44
Bohorquez, Lissette Yagual, Evelyn Valencia-Espinoza, Emiliano Pulla-Cadmilema, et al. "Abstract P4-07-07: Impact on overall survival according to sites of metastasis: Real-world data." Cancer Research 83, no. 5_Supplement (2023): P4–07–07—P4–07–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-07-07.
Full textAbstract:
Abstract Background Metastatic breast cancer, has a heterogeneous presentation and management, therefore its overall survival ranges from 2 to 3 years. Despite advances in breast cancer screening, diagnosis, and treatment, nearly 12-30% of early stage breast cancer patients eventually develop metastatic disease. In Ecuador, breast cancer is the most common malignancy among women, and the leading cause of newly diagnose cancer in the general population (Globocan 2020). This study aims to determine the frequency of metastatic sites and its impact in overall survival. Methods: An observational, retrospective, descriptive, single-center study was carried out. All patients with Metastatic breast cancer who had been treated at the National Oncology Institute SOLCA Guayaquil, in the period from 2016 to 2020 were included in the analysis. All statistical analyses were performed using SPSS for Windows (version 25.0;SPSS). The Kolmogorov-Smirnov test was used to test for the normality of distribution. Correlations were determined with Spearman correlation coefficients. The number of metastatic sites were recorded and their impact on overall survival was calculated by the Kaplan-Meier method and compared by the long-rank test, multivariable adjusted hazard ratios (HR) were estimated by Cox regression models. Results: A total of 1113 patients were included in the analysis, of which 84 patients (7.5%) were metastatic disease. The distribution of metastatic sites at diagnosis were: bone 64% (n=53), lung 51% (n=42), liver 30% (n=25), soft tissues 23% (n=19), and the least frequent were metastases to the central nervous system 17% (n=14), mediastinal lymph node 5% (n=4), peritoneal lymph node 1% (n=1). Regarding metastatic sites, 41% (N: 35) had only 1 metastatic site, 33,7% (N: 28) had 2 metastatic sites, and 25.3% (N:21) has 3 or more sites. A multivariable analysis was performed which takes into account all the metastases in the analysis. All have a higher risk of mortality vs not having any metastasis (all are greater than 1). But the only significant one is CNS with a RR 1,31 (1,08 - 1,61) P=0,005. Three or more sites of metastasis have RR 1,22 (0.95-1.57) p: 0.11. Relative Risk (RR) according to the different sites of metastasis are shown in the table#1. The association between 3 or more sites of metastasis showed a negative impact on overall survival (15 months +/-2.3 SD vs 36 months +/- 3.7 SD) compared to 1 site of metastasis. Conclusions: Approximately half of the women (N:49) with metastatic breast cancer in our population presented 2 or more sites of metastasis, which significantly decreases overall survival. The central nervous system is the site of metastasis with the highest relative risk of mortality, generating functional deterioration, adding morbidity, and only 64% (9 out of 14) of the patients access to radiotherapy as palliative treatment. Thus, better strategies for early diagnosis and adequate treatment of metastatic disease should be developed. Citation Format: Lissette Yagual Bohorquez, Evelyn Valencia-Espinoza, Emiliano Pulla-Cadmilema, Lissette P. Velez Avila, Maria del Mar Sanchez Salazar, Patricia Tamayo Aguilar, Jimmy Martin-Delgado, Glenda Ramos Martinez, Katherine Garcia Matamoros, Felipe Campoverde Merchan, Ruth Engracia Vivanco, Mayra Santacruz Maridueña, Roberto Escala Cornejo, Isabel Delgado Guerrero, Veronica Torres Floril, Diego Garcia Gamboa, Elina A. Rodriguez-Melendez. Impact on overall survival according to sites of metastasis: Real-world data [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-07-07.
45
Aguado, Cristina A., Beatriz Garcia, Andrés Aguilar-Hernández, et al. "Abstract 1610: Primary cultures from malignant pleural effusions and ascites for drug screening in personalized therapy." Cancer Research 82, no. 12_Supplement (2022): 1610. http://dx.doi.org/10.1158/1538-7445.am2022-1610.
Full textAbstract:
Abstract Background: A significant percentage of patients (p.) with solid tumors present with pleural effusion or ascitic fluid during disease history. Although isolation of viable malignant cells from these fluids for drug screening and other experimental purposes have been described in the literature, the success rate in obtaining pure cultures is low and the technique is rarely employed in the clinical setting. Here, we present the results of the implementation in our hospital of routine primary culture and subsequent drug testing from pleural effusions and ascites. Methods: 22 pleural effusions (PE) and 11 ascitic fluid from 33 p. were collected; three colon, one esophagous, one melanoma, eight ovarian, one pancreatic and 19 lung cancer. Total cells were isolated by centrifugation, erythrocytes discarded by density gradient and the remaining cells cultured in RPMI + 20%FBS. Primary cultures were genotyped by next generation sequencing (NGS), FISH, qPCR and nCounter. The antitumor effects of several drugs were tested by MTT, including tyrosine kinase, PARP and KRAS inhibitors and chemotherapeutic agents such as cis-platinum or pemetrexed. Results: Primary cultures were attempted from 33 malignant pleural effusions and ascites samples. Cells grew ≥3 passages and were genotyped in 28/33 cases (84%). Eleven primary cultures were pan-negative by NGS, suggesting that they derived either from non-tumor cells or from a minor sub-clone within the tumor. In contrast, 17 primary cultures showed alterations in oncogenes or tumor supressor genes, allelic fractions were ≥70% in 11 cases. Synchronous liquid biopsies or FFPE biopsies were available for the 17 primary cultures; the same genetic alterations were present in all cases. Five primary cultures with drivers at ≥70% allelic fraction (KRAS G12C; ALK and ROS1 fusions; MET and FGFR1 amplifications) were used for MTT assays. In the three cases where the patient was administered the same drugs tested in primary cultures, results were concordant. Conclusions: Primary culture of pleural effusions and ascites can be implemented in the clinical setting with a significant success rate. Drug testing in primary cultures can be of help in treatment selection. Citation Format: Cristina A. Aguado, Beatriz Garcia, Andrés Aguilar-Hernández, Alejandro Martínez-Bueno, Marta Vives-Usano, Florencia Garcia-Casabal, Ruth Román, Ekaterina Meshoulam, Erika Aldeguer, Nuria Jordana-Ariza, Juan José García-Mosquera, Carlos Cabrera, Santiago Viteri, Sonia Rodríguez, Laura Berrocal-Gómez, Pablo Rubinstein, Clara Mayo-de-las-Casas, Rafael Rosell, Miguel Ángel Molina-Vila. Primary cultures from malignant pleural effusions and ascites for drug screening in personalized therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1610.
46
Li, Caroline M., Krystine Garcia-Mansfield, Robert G. Lingeman, et al. "Abstract 1850: From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase." Cancer Research 84, no. 6_Supplement (2024): 1850. http://dx.doi.org/10.1158/1538-7445.am2024-1850.
Full textAbstract:
Abstract Proteomic changes were investigated in a neuroblastoma cell line, SK-N-AS, treated with a small molecule inhibitor, AOH1996, designed to specifically bind proliferating cell nuclear antigen (PCNA) in cancer. PCNA is crucial to DNA replication, DNA repair, transcription, cell cycle control, and chromatin organization through interactions with different proteins. Pathway analysis of differential protein expressions between treated and untreated cells revealed less G2/M DNA damage checkpoint regulation and decreased assembly of RNA polymerase complex. Phosphoproteomic analysis by PTM Signature Enrichment Analysis (PTM-SEA) identified signatures of kinase activities, signaling pathways, and perturbations. Specifically, the histone deacetylase inhibitors belinostat and vorinostat were identified as enriched perturbation signatures. Both inhibitors were tested in combination with AOH1996 in SK-N-AS as well as cell lines derived from breast, lung, ovarian, and pancreatic cancer, revealing drug synergies at specific dose combinations. Western blot analysis showed that belinostat decreased protein expression of PCNA, suggestive of mechanistic synergies with AOH1996+belinostat combination therapies. Our proteomic analysis reveals a therapeutic potential of combining AOH1996 and histone deacetylase inhibitors for treating cancer with possibly lower drug dose and toxicities compared to single drug treatment. Citation Format: Caroline M. Li, Krystine Garcia-Mansfield, Robert G. Lingeman, Long Gu, Robert J. Hickey, Patrick Pirrotte, Linda H. Malkas. From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1850.
47
Bruder, H. "Manuel Garcia (1775-1832): Chronicle of the Life of a "Bel Canto" Tenor at the Dawn of Romanticism." Opera Quarterly 18, no. 3 (2002): 442–47. http://dx.doi.org/10.1093/oq/18.3.442.
Full text
48
Regner, Matthew J., Aatish Thennavan, Susana Garcia-Recio, et al. "Abstract 5754: Determining the regulatory logic of breast cancer cells using single-cell multi-omics." Cancer Research 83, no. 7_Supplement (2023): 5754. http://dx.doi.org/10.1158/1538-7445.am2023-5754.
Full textAbstract:
Abstract Cancer cells rewire regulatory elements scattered throughout the genome (such as enhancers) to drive aberrant gene expression. Thus, deconvoluting the regulatory mechanisms that contribute to oncogenic gene expression in cancer cells is key to understanding tumor biology. To this end, we have charted the transcriptional and epigenetic landscape of breast cancer at single-cell resolution to quantitatively link variation in chromatin accessibility to gene expression across malignant and non-malignant cell types. Our comprehensive dataset profiles the chromatin landscape (scATAC-seq) in concert with the transcriptional profiles (scRNA-seq) of 4 breast cancer cell lines, 12 primary breast tumors, and 4 normal mammary reduction tissue specimens collected and processed immediately after surgical resection. This dataset, encompassing over 250,000 individual cells, allowed us to define the regulatory logic of cancer cells by 1) revealing how the epigenome underlies cellular heterogeneity of these tumors in comparison to normal mammary tissue, 2) defining how malignant cells hijack enhancer elements to drive key transcriptional programs in a subtype-specific manner, and 3) annotating which cancer-specific enhancer-to-gene connections portend a worse outcome in patients. Notably, we discovered that cancer cells acquire de novo non-coding enhancer elements to modulate hallmark cancer pathways that were previously hidden using bulk genomics approaches. This highlights the potential for cancer-specific enhancers to serve as markers with diagnostic and prognostic potential, or even serve as tractable targets for therapeutic intervention. Together these data enable the annotation of the cellular composition, transcriptional, and epigenetic landscape of breast tumors to help pinpoint clinically relevant mechanisms of tumorigenesis. Citation Format: Matthew J. Regner, Aatish Thennavan, Susana Garcia-Recio, Kamila Wisniewska, Philip M. Spanheimer, Joel S. Parker, Charles M. Perou, Hector L. Franco. Determining the regulatory logic of breast cancer cells using single-cell multi-omics. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5754.
49
Izquierdo, Maxim, Sonia Baulies, Carmen Ara, et al. "Abstract PO2-26-06: Prognostic factors pregnancy associated breast cancer: one year versus two years." Cancer Research 84, no. 9_Supplement (2024): PO2–26–06—PO2–26–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-26-06.
Full textAbstract:
Abstract Aims: The trend of delayed delivery, the number of women with breast cancer during a pregnancy or in the years after pregnancy is expected to increase Pregnancy breast cancer confers a worse prognostic. Study if the interval pregnancy breast cancer more one year to two years influences the prognostic factors like pregnancy breast cancer one year after Methods: Study 1186 patients with breast cancer and prognostic factors. Analyze delivery before breast cancer, and the interval of last childbirth, one year, more one year to two years and more two years, with prognostic factors (nodes, estrogen receptor, progesterone receptor, HER2 receptor and Ki 67) Results: Breast cancer pregnancy one year after were in 37 patients, more one year to two years in 25 patients and more two years in 491 patients. Positive nodes one year after were in 21 patients, more one year to two year were in seven patients (p < 0'05), and more two years in 155 patients (p=ns). There are not differences (p=ns) in estrogen receptor, progesterone receptor and Ki67, one year versus more one year to two years and more to two years. HER2 and histologic grade there are not differences (p=ns) in one year after versus more one year to two years, but there are differences (p < 0’05) versus more two years Conclusion: Interval last childbirth breast cancer more than one year to two years influences prognostic factors for later breast cancer, and not have differences with prognostic factors than pregnancy one year after Citation Format: Maxim Izquierdo, Sonia Baulies, Carmen Ara, Maria Garcia, Fransec Fargas, Rafael Fabregas, Fransec Tresserra, Pere Barri S. Prognostic factors pregnancy associated breast cancer: one year versus two years [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-26-06.
50
Conejo-Garcia, Jose R. "Abstract IA017: Spontaneous humoral responses in endometrial cancer provide a rationale for novel tumor-penetrating therapeutic antibodies." Clinical Cancer Research 30, no. 5_Supplement (2024): IA017. http://dx.doi.org/10.1158/1557-3265.endo24-ia017.
Full textAbstract:
Abstract The role of humoral responses in endometrial cancer remains insufficiently investigated. Using a cohort of 107 patients with different histological subtypes of endometrial carcinoma, we found that concomitant accumulation of T, B, and plasma cells at tumor beds predicted better survival. However, only B cell markers corresponded with prolonged survival specifically in high-grade endometrioid type and serous tumors. Immune protection was associated with class-switched IgA and, to a lesser extent, IgG. Expression of polymeric immunoglobulin receptor (PIGR) by tumor cells allow dimeric IgA transcytosis. Taking advantage of tumor cell penetration, we demonstrated that mutation-specific dIgA, but not IgG, neutralized KRASG12D inside carcinoma cells and expelled this oncodriver (but not wild-type KRAS) outside tumor cells, abrogating tumor cell proliferation in an antigen-specific manner. Accordingly, KRASG12D-specific dIgA1, but not the same antibody on an IgG backbone, abrogated KRASG12D carcinoma growth in vivo, more effectively than small molecule KRASG12D inhibitors, including in syngeneic tumor-bearing immunocompetent mice. Because >6% of endometrial cancers exhibit KRAS mutations, our results provide a rationale for developing PIGR-targeting tumor cell-penetrating antibodies to effectively target intracellular oncogenes, which could be applicable to many aggressive and frequent human cancers. Citation Format: Jose R. Conejo-Garcia. Spontaneous humoral responses in endometrial cancer provide a rationale for novel tumor-penetrating therapeutic antibodies [abstract]. In: Proceedings of the AACR Special Conference on Endometrial Cancer: Transforming Care through Science; 2023 Nov 16-18; Boston, Massachusetts. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(5_Suppl):Abstract nr IA017.