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1

Jiang, Dongneng, Liqun Zhang, Fei Liu, Chang Liu, Linlin Liu, and Xiaoyun Pu. "An electrochemiluminescence sensor with dual signal amplification of Ru(bpy)32+based on PtNPs and glucose dehydrogenase for diagnosis of gas gangrene." RSC Advances 6, no. 24 (2016): 19676–85. http://dx.doi.org/10.1039/c5ra27241f.

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Gas gangrene is a bacterial infection that produces gas in tissues in gangrene.C. perfringenswith alpha-toxin plays a key role in gas gangrene. Detection ofC. perfringensis highly important in clinical diagnosis of gas gangrene.
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2

Stephens, Lt Mark B. "Gas gangrene." Postgraduate Medicine 99, no. 4 (1996): 217–24. http://dx.doi.org/10.1080/00325481.1996.11946109.

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3

Schexnayder, Stephen M., and Sarah G. Klein. "Gas Gangrene." New England Journal of Medicine 350, no. 25 (2004): 2603. http://dx.doi.org/10.1056/nejmicm980151.

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4

Pitt, M., N. J. Purser, Gilles Bouachour, JeanPaul Gouello, Patrick Harry, and Philippe Alquier. "Gas gangrene." Lancet 347, no. 9008 (1996): 1116–17. http://dx.doi.org/10.1016/s0140-6736(96)90315-3.

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5

Coleman, D. J., and A. G. Batchelor. "Gas gangrene." BMJ 296, no. 6636 (1988): 1600–1601. http://dx.doi.org/10.1136/bmj.296.6636.1600-a.

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6

Golledge, C., A. Keil, and T. McKenzie. "Gas gangrene." BMJ 296, no. 6636 (1988): 1601. http://dx.doi.org/10.1136/bmj.296.6636.1601.

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7

Bignardi, G. E. "Gas gangrene." BMJ 296, no. 6637 (1988): 1671. http://dx.doi.org/10.1136/bmj.296.6637.1671.

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8

Maddocks, J. L. "Gas gangrene." BMJ 297, no. 6642 (1988): 204. http://dx.doi.org/10.1136/bmj.297.6642.204-c.

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9

Lehner, P. J., and H. Powell. "Gas gangrene." BMJ 303, no. 6796 (1991): 240–42. http://dx.doi.org/10.1136/bmj.303.6796.240.

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10

Mercer, N., and D. M. Davies. "Gas gangrene." BMJ 303, no. 6806 (1991): 854–55. http://dx.doi.org/10.1136/bmj.303.6806.854-b.

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11

Owen, E. R. T. C., and P. J. Lehner. "Gas gangrene." BMJ 303, no. 6806 (1991): 854–55. http://dx.doi.org/10.1136/bmj.303.6806.854-c.

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12

Echigoya, Ryosuke, Akira Kuriyama, and Noriyuki Umakoshi. "Hepatic Gas Gangrene." Internal Medicine 54, no. 10 (2015): 1319. http://dx.doi.org/10.2169/internalmedicine.54.4149.

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13

Sorbie, Charles. "Atraumatic Gas Gangrene." Orthopedics 26, no. 10 (2003): 1005. http://dx.doi.org/10.3928/0147-7447-20031001-04.

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14

Valentinecol, Elizabeth G. "Nontraumatic Gas Gangrene." Annals of Emergency Medicine 30, no. 1 (1997): 109–11. http://dx.doi.org/10.1016/s0196-0644(97)70121-5.

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15

Cour, Morten, Annette Nørgaard, Jan Ulrik Prause, and Erik Scherfig. "Gas gangrene panophthalmitis." Acta Ophthalmologica 72, no. 4 (2009): 524–28. http://dx.doi.org/10.1111/j.1755-3768.1994.tb02808.x.

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16

Lyon, David B., and Bradley N. Lemke. "Eyelid Gas Gangrene." Ophthalmic Plastic & Reconstructive Surgery 5, no. 3 (1989): 212–15. http://dx.doi.org/10.1097/00002341-198909000-00013.

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17

Tsimkhes, I. "Gas gangrene after drug injections. Dr. Herbert lunghans (Deutsch.medic. Wochenschr. 1933. No. 22)." Kazan medical journal 29, no. 10 (2022): 837. http://dx.doi.org/10.17816/kazmj90161.

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Gas gangrene after drug injections. Dr. Herbert liinghans (Deutsch.medic. Wochenschr. 1933. No. 22), after analyzing his case of gas gangrene after an injection of digipurate, cites from the literature 60 cases where gas gangrene developed at the injection site of the same medicinal substances.
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18

Bakhshi, Girish D., Owais Ahmed Patel, Dinesh Pawar, and Jessicka Shah. "Non-clostridial gas gangrene of a diabetic foot with COVID-19 infection." International Surgery Journal 7, no. 9 (2020): 3156. http://dx.doi.org/10.18203/2349-2902.isj20203816.

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Gas gangrene is a manifestation of soft tissue infection by clostridial group of bacteria. Non-clostridial gas gangrene is uncommon and seen rarely in diabetics. In the era of COVID-19 pandemic where COVID-19 itself induces hyperglycemia non clostridial gas gangrene may arise due to altered immunity. We present a case of non clostridial gas gangrene of lower limb in a middle aged person who was not a known diabetic. A brief case report with review of literature is presented.
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19

Delbridge, M. S., E. P. L. Turton, and R. C. Kester. "Spontaneous fulminant gas gangrene." Emergency Medicine Journal 22, no. 7 (2005): 520–21. http://dx.doi.org/10.1136/emj.2003.013144.

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20

Kirk, C. R. "Gas gangrene: Authors' reply." BMJ 296, no. 6637 (1988): 1671. http://dx.doi.org/10.1136/bmj.296.6637.1671-a.

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21

Jamieson, N. F. "Gas gangrene after colonoscopy." Postgraduate Medical Journal 77, no. 903 (2001): 47–49. http://dx.doi.org/10.1136/pmj.77.903.47.

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22

Gentile, J., S. Gentile, O. Garcia Allende, and M. Sparo. "Spontaneous Hepatic Gas Gangrene." Anaerobe 5, no. 3-4 (1999): 395–96. http://dx.doi.org/10.1006/anae.1999.0229.

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23

Asao, Rin, Kazumasa Nishida, Hiromichi Goto, Yoshikazu Goto, Noriatsu Ichiba, and Isao Ohsawa. "Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient." CEN Case Reports 9, no. 4 (2020): 308–12. http://dx.doi.org/10.1007/s13730-020-00456-y.

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Abstract Recently, postmortem imaging is sometimes used as an alternative to conventional autopsy. However, there are few case reports of postmortem imaging of dialysis patients. Here, we report a fatal case of gas gangrene involving a 76-year-old man who underwent dialysis. He died suddenly before a diagnosis could be established. Immediately after his death, postmortem computed tomography (PMCT) revealed gas accumulation in his right upper extremity and ascending aorta. Gas gangrene progresses rapidly and may sometimes result in sudden death before it is diagnosed. In this case, PMCT finding
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24

Katzir, Alona, Max Gordon, Yoram A. Weil, and Mahmoud Jammal. "A Rare Case of Gas Gangrene after Upper Limb Fracture." Journal of Orthopaedic Case Reports 15, no. 1 (2025): 99–102. https://doi.org/10.13107/jocr.2025.v15.i01.5140.

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Introduction: Gas gangrene, is an aggressive and life-threatening necrotizing infection of soft tissues. We report a case of upper-limb trauma resulting in clostridial gas gangrene. Case Report: A 36-year-old healthy male presented to our department with a left humeral shaft fracture and an open elbow fracture. During surgery wound discharge, and diffuse crepitations due to gaseous accumulation were noted around the medial elbow and forearm. Debridement and fasciotomy were performed, and IV penicillin and clindamycin were administrated. The infection spread into adjacent soft tissues, requirin
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25

Javier, R. Mohamad, Yuswar Nurullah Sukin, Mochamad Yunus, and Mochamad Aleq Sander. "Profile of Pedis Gangrene Patients With Type Ii Diabetes Mellitus at Bhayangkara Hospital Kediri Period January 2021 - March 2022." Eduvest - Journal of Universal Studies 2, no. 9 (2022): 1868–80. http://dx.doi.org/10.59188/eduvest.v2i9.590.

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Gas gangrene is a disease that is identical to the incidence of type 2 diabetes mellitus with the characteristics of muscle necrosis / myonecrosis and is a very deadly infection of the inner soft tissues, often caused by gram-positive bacteria such as Staphylococcus aureus, Clostridium perifingens. Diabetes mellitus is a collection of symptoms caused by disturbances in the balance between carbohydrates, fats and proteins caused by absolute or relative insulin deficiency, causing hyperglycemia and glucosuria. to describe the profile of patients with gas gangrene pedis caused by type II diabetes
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26

Javier, R. Mohamad, Yuswar Nurullah Sukin, Mochamad Yunus, and Mochamad Aleq Sander. "Profile of Pedis Gangrene Patients With Type Ii Diabetes Mellitus at Bhayangkara Hospital Kediri Period January 2021 - March 2022." Eduvest - Journal of Universal Studies 2, no. 9 (2022): 1868–80. http://dx.doi.org/10.36418/eduvest.v2i9.590.

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Gas gangrene is a disease that is identical to the incidence of type 2 diabetes mellitus with the characteristics of muscle necrosis / myonecrosis and is a very deadly infection of the inner soft tissues, often caused by gram-positive bacteria such as Staphylococcus aureus, Clostridium perifingens. Diabetes mellitus is a collection of symptoms caused by disturbances in the balance between carbohydrates, fats and proteins caused by absolute or relative insulin deficiency, causing hyperglycemia and glucosuria. to describe the profile of patients with gas gangrene pedis caused by type II diabetes
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27

Sacco, Sofia C., Joaquín Ortega, Mauricio A. Navarro, et al. "Clostridium sordellii–associated gas gangrene in 8 horses, 1998–2019." Journal of Veterinary Diagnostic Investigation 32, no. 2 (2019): 246–51. http://dx.doi.org/10.1177/1040638719877844.

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Gas gangrene occurs in several animal species and is caused by one or more clostridial species. In horses, the disease is most often caused by Clostridium perfringens type A. Although Clostridium sordellii has been associated with gas gangrene in ruminants and humans, cases of the disease associated with this microorganism have not been described in horses, to our knowledge. We report herein 8 cases of gas gangrene caused by C. sordellii in horses. These cases were characterized by myonecrosis and cellulitis, associated with systemic changes suggestive of toxic shock. The diagnosis was confirm
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28

Ying, Zhimin, Min Zhang, Shigui Yan, and Zhong Zhu. "Gas Gangrene in Orthopaedic Patients." Case Reports in Orthopedics 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/942076.

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Clostridial myonecrosis is most often seen in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. Since 1953 cases of gas gangrene have been reported in orthopaedic patients including open fractures, closed fractures, and orthopaedic surgeries. We present a case of 55-year-old obese woman who developed rapidly progressive gas gangrene in her right leg accompanied by tibial plateau fracture without skin lacerations. She was diagnosed with clostridial myonecrosis and above-the-knee amputation was carried out. This patient made full recovery within three we
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29

Dylewski, Joe, Robert Drummond, and John Rowen. "A case of Clostridium septicum spontaneous gas gangrene." CJEM 9, no. 02 (2007): 133–35. http://dx.doi.org/10.1017/s1481803500014950.

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ABSTRACT Severe skin and soft tissue infections (SSTIs) are often life-threatening emergencies that require a rapid diagnosis. Gas gangrene is one of the most fulminant types of SSTI and is usually caused by Clostridium perfringens' contamination of an open wound. Although gas gangrene is usually associated with fecally contaminated wounds, “spontaneous” cases occur and are most commonly caused by Clostridium (C.) septicum. We report a case of spontaneous gas gangrene caused by C. septicum that only became manifest while the patient was being monitored in the emergency department. We also revi
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30

Junior, Carlos A. Oliveira, Rodrigo O. S. Silva, Francisco C. F. Lobato, Mauricio A. Navarro, and Francisco A. Uzal. "Gas gangrene in mammals: a review." Journal of Veterinary Diagnostic Investigation 32, no. 2 (2020): 175–83. http://dx.doi.org/10.1177/1040638720905830.

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Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. Clostridium chauvoei, C. septicum, C. novyi type A, C. perfringens type A, and C. sordellii are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Gross and microscopic lesions are, however, hig
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31

Misiakos, Evangelos P., Nick Zabras, George Bagias, et al. "Uncommon Locations of Gas Gangrene Treated Successfully With Surgical Debridement and the Vacuum-Assisted Closure Device." International Surgery 101, no. 11-12 (2016): 517–23. http://dx.doi.org/10.9738/intsurg-d-14-00296.1.

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Gas gangrene is a life-threatening condition implying necrosis of dermis and hypodermis, along with necrosis of the superficial muscular aponeurosis. Fournier s gangrene is a subtype of the disease affecting the perineal and genital area. The aim of this study is to analyze the clinical presentation, diagnosis, medical, and surgical treatment of three cases of gas gangrene affecting uncommon locations in the human body, treated with extensive surgical debridement followed by the vacuum assisted closure method in two of these cases. Three cases of gas gangrene affecting uncommon locations treat
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32

MASAKI, Takayuki, Hozo UMEHASHI, Hiroshi MIYAZAKI, Makoto TAKANO, Kiyotaka YAMAKAWA, and Shinichi NAKAMURA. "CLOSTRIDIUM ABSONUM FROM GAS GANGRENE." Japanese Journal of Medical Science and Biology 41, no. 1 (1988): 27–30. http://dx.doi.org/10.7883/yoken1952.41.27.

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33

SEIDEL, MONIKA, MICHAEL WEISS, THOMAS NICOLAI, REINHARD ROOS, RAINER GRANTZOW, and BERND H. BELOHRADSKY. "Gas gangrene and congenital agranulocytosis." Pediatric Infectious Disease Journal 9, no. 6 (1990): 437–39. http://dx.doi.org/10.1097/00006454-199006000-00014.

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34

Sharma, Pooja, Nadeem Tanveer, and Sonali Dixit. "Histopathological features of gas gangrene." Indian Journal of Pathology and Microbiology 65, no. 1 (2022): 211–12. http://dx.doi.org/10.4103/ijpm.ijpm_1236_20.

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35

McCloskey, Malachy, and Vincent HS Low. "CT of pancreatic gas gangrene." Australasian Radiology 40, no. 1 (1996): 75–76. http://dx.doi.org/10.1111/j.1440-1673.1996.tb00351.x.

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36

JOSEPHEA, A. "Gas gangrene of the pancreas." American Journal of Gastroenterology 96, no. 9 (2001): S211. http://dx.doi.org/10.1016/s0002-9270(01)03450-5.

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37

Lindsay, D. "Clostridium perfringens and gas gangrene." Journal of Trauma: Injury, Infection, and Critical Care 26, no. 12 (1986): 1156. http://dx.doi.org/10.1097/00005373-198612000-00031.

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38

Hengster, Paul, and Heinz Pernthaler. "Gas gangrene: necropsy is imperative." Lancet 347, no. 9000 (1996): 553. http://dx.doi.org/10.1016/s0140-6736(96)91189-7.

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39

Ketterl, R., T. Beckurts, J. Kovacs, B. Stu¨binger, R. Hipp, and B. Claudi. "Gas-gangrene following arthroscopic surgery." Arthroscopy: The Journal of Arthroscopic & Related Surgery 5, no. 1 (1989): 79–83. http://dx.doi.org/10.1016/0749-8063(89)90098-4.

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40

Kashiura, Masahiro, Kazuki Miyazaki, Hidenobu Fujita, and Yuichi Hamabe. "Blackish haematuria and gas gangrene." Intensive Care Medicine 42, no. 9 (2016): 1498–99. http://dx.doi.org/10.1007/s00134-016-4412-6.

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41

Sawhney, R., J. H. Rees, and S. K. Markowitz. "Clostridial gas gangrene complicating leukemia." Abdominal Imaging 19, no. 5 (1994): 451–52. http://dx.doi.org/10.1007/bf00206938.

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42

Ishizuka, Tetsuo, Tetsuo Senba, Yasushi Ota, and Ken Ito. "Gas Gangrene in the Neck." Practica Oto-Rhino-Laryngologica 86, no. 1 (1993): 113–18. http://dx.doi.org/10.5631/jibirin.86.113.

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43

Kirk, C. R., J. C. Dorgan, and C. A. Hart. "Gas gangrene: a cautionary tale." BMJ 296, no. 6631 (1988): 1236–37. http://dx.doi.org/10.1136/bmj.296.6631.1236.

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44

Mayer, Gabriel, and Rodney Kang. "Gas gangrene, diabetes, and cholecystitis." American Journal of Emergency Medicine 3, no. 1 (1985): 42–45. http://dx.doi.org/10.1016/0735-6757(85)90011-7.

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45

Komarovskaya, E. I., and O. V. Perelygina. "Current incidence of certain clostridial infections: gas gangrene and tetanus." BIOpreparations. Prevention, Diagnosis, Treatment 21, no. 1 (2021): 31–38. http://dx.doi.org/10.30895/2221-996x-2021-21-1-31-38.

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Clostridial myonecrosis or gas gangrene (myonecrosis) and tetanus are relatively rare nowadays, but they are still considered serious conditions associated with poor prognosis and high mortality. Life-threatening infections caused by Clostridium species have been known and studied for centuries, as they differed from other infections in terms of typical clinical manifestations, challenges of therapy and prevention. The aim of the study was to analyse the global incidence of gas gangrene and tetanus and challenges of prevention and treatment of these diseases. The review of up-to-date scientifi
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46

Bajpai, Vijeta, Aishwarya Govindaswamy, Sonu Kumari Agrawal, Rajesh Malhotra, and Purva Mathur. "Clostridium sordelli as a cause of gas gangrene in a trauma patient." Journal of Laboratory Physicians 11, no. 01 (2019): 094–96. http://dx.doi.org/10.4103/jlp.jlp_108_18.

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AbstractGas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is Clostridium perfringens followed by Clostridium septicum. Here, we are reporting an unusual case report of posttraumatic gas gangrene caused by Clostridium sordelli.
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47

Niimi, Masanori, Yosifumi Ikeda, Shigenao Kan, and Hiroshi Takami. "Gas Gangrene in Patient with Atherosclerosis Obliterans." Asian Cardiovascular and Thoracic Annals 10, no. 2 (2002): 178–80. http://dx.doi.org/10.1177/021849230201000223.

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Clostridia are the main cause of nontraumatic spontaneous gas gangrene. Poor blood flow due to arterial occlusion exacerbates the anaerobic condition. Fulminant gas gangrene in a 54-year-old man with atherosclerosis obliterans was treated by revascularization of the iliac artery using endarterectomy, and his gangrenous lower leg was amputated. However, he died from renal failure.
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48

Önder, Taylan, Sevil Alkan, and Seyhan Tezcan. "A case of Fournier’s gangrene caused by Rothia dentocariosa." Iberoamerican Journal of Medicine 5, no. 2 (2023): 84–87. http://dx.doi.org/10.53986/ibjm.2023.0012.

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We report a case of Fournier's gangrene rescued by debridement. A 40-year-old male patient had a 2x2 cm draining ulcer and 1x2 cm necrotic area in the scrotum for about a month. The patient was diagnosed with Fournier's gangrene. Septic shock and disseminated intravascular coagulation were absent. Computed tomography scan showed soft tissue gas in the scrotum but no gas in the retroperitoneal space or abdominal wall. Debridement was performed. Gangrene of the scrotum and necrosis of the testicle was also seen. Rothia dentocariosa was isolated in extracted wound cultures. He was saved after deb
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49

Harika, D. Navya Sesha, T. Uma Maheswara Rao, P. Sireesha, D. Jithendra, and Satya Sundeep Pandu. "A rare case of gas under diaphragm due to spontaneous perforation of uterus due to gas gangrene of uterus with clostridium perfringens infection presenting as intestinal perforation." International Surgery Journal 6, no. 8 (2019): 3009. http://dx.doi.org/10.18203/2349-2902.isj20193362.

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Uterine perforation is an uncommon, perforation due to clostridium perfringens is very rare, but potentially serious complication of uterine gangrene is due to clostridial infection, uterine manipulation, evacuation of retained products, termination of pregnancy, during coil insertion and hysteroscopic procedures. We report a 60 year old female patient presented with abdominal pain, constipation and Fever with features of septic shock. X-ray showed free gas under both domes of diaphragm. CT showed gas under diaphragm and hollow viscus perforation. This report aims to alert surgeons to the poss
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50

Ghosh, Sujoy, Abhijit M. Bal, Iqbal Malik, and Andrew Collier. "Fatal Morganella morganii bacteraemia in a diabetic patient with gas gangrene." Journal of Medical Microbiology 58, no. 7 (2009): 965–67. http://dx.doi.org/10.1099/jmm.0.008821-0.

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We report a case of a 60-year-old lady with a history of a heel ulcer that had not responded to antibiotic therapy. This progressed to involve the right leg, which was swollen and erythematous. Radiological imaging revealed the presence of gas within the fascial planes. Blood cultures on admission yielded Morganella morganii. Due to the extent of the gas gangrene and her co-morbidities the patient was not suitable for surgical intervention and was treated conservatively with antibiotics. She deteriorated and died within 72 h of presentation. Non-clostridial gas gangrene is relatively rare, and
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