Log in

Relevant bibliographies by topics / Gaseous mediator / Journal articles

To see the other types of publications on this topic, follow the link: Gaseous mediator.

Journal articles on the topic 'Gaseous mediator'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Gaseous mediator.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Zhu, Zhixing, Stephen Chambers, Yiming Zeng, and Madhav Bhatia. "Gases in Sepsis: Novel Mediators and Therapeutic Targets." International Journal of Molecular Sciences 23, no. 7 (2022): 3669. http://dx.doi.org/10.3390/ijms23073669.

Full text

Abstract:

Sepsis, a potentially lethal condition resulting from failure to control the initial infection, is associated with a dysregulated host defense response to pathogens and their toxins. Sepsis remains a leading cause of morbidity, mortality and disability worldwide. The pathophysiology of sepsis is very complicated and is not yet fully understood. Worse still, the development of effective therapeutic agents is still an unmet need and a great challenge. Gases, including nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S), are small-molecule biological mediators that are endogenously

APA, Harvard, Vancouver, ISO, and other styles

2

Sulaieva, O. N., and J. L. Wallace. "New strategy for gastrointestinal protection based on gaseous mediators application." Russian Journal of Gastroenterology, Hepatology, Coloproctology 26, no. 3 (2016): 17–23. http://dx.doi.org/10.22416/1382-4376-2016-26-3-17-23.

Full text

Abstract:

The aim of review. To assess protective mechanisms and efficacy of gaseous mediators based antiinflammatory therapy. Key points. Nowadays there are no reasonable and effective methods of prevention and treatment of NSAID-induced intestinal lesions. The discovery of powerful anti-inflammatory and cytoprotective effects of endogenous gaseous mediators (nitric oxide, hydrogen sulfide, carbon monoxide) led to development of new combined nonsteroidal anti-inflammatory drugs (NSAIDs), which in addition to cyclooxygenase inhibitor include gas-releasing molecules. One of such molecules is hydrogen sul

APA, Harvard, Vancouver, ISO, and other styles

3

Evelyn, Edy Saputra, Amun Amri, Aaron Marshall, and Peter Gostomski. "Reaction kinetics for microbial-reduced mediator in an ethanol-fed microbial fuel cell." MATEC Web of Conferences 276 (2019): 06010. http://dx.doi.org/10.1051/matecconf/201927606010.

Full text

Abstract:

Microbial fuel cell (MFC) is an emerging energy production technology which converts the chemical energy stored in biologically degradable compounds to electricity at high efficiency. MFC with added mediator can enhance the electron transfer from the microbes to the anode, and used to treat industrial waste gases. In this work, the rate of microbial-reduced mediator reaction at the surface of glassy carbon (GC) electrode in an ethanol-fed MFC was investigated using cyclic voltammetry (CV), and compared with linear sweep voltammetry (LSV). The CV method provided a better estimation of the kinet

APA, Harvard, Vancouver, ISO, and other styles

4

Sulaieva, Oksana, and John L. Wallace. "Gaseous mediator-based anti-inflammatory drugs." Current Opinion in Pharmacology 25 (December 2015): 1–6. http://dx.doi.org/10.1016/j.coph.2015.08.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Ritter, JM. "Human pharmacology of hydrogen sulfide, putative gaseous mediator." British Journal of Clinical Pharmacology 69, no. 6 (2010): 573–75. http://dx.doi.org/10.1111/j.1365-2125.2010.03690.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Perrotta, Cristiana, and Emilio Clementi. "Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide." Physiology 25, no. 2 (2010): 64–71. http://dx.doi.org/10.1152/physiol.00048.2009.

Full text

Abstract:

Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.

APA, Harvard, Vancouver, ISO, and other styles

7

Carraro, S., C. Cutrone, C. Cardarelli, S. Zanconato, and E. Baraldi. "Clinical Application of Nasal Nitric Oxide Measurement." International Journal of Immunopathology and Pharmacology 23, no. 1_suppl (2010): 50–52. http://dx.doi.org/10.1177/03946320100230s113.

Full text

Abstract:

Nitric oxide is present in high concentration in the upper respiratory tract. The main source of this gaseous molecule is the paranasal sinus epithelium. The physiological role of this mediator is to contribute to local host defense, modulate ciliary motility and serve as an aerocrine mediator in helping to maintain adequate ventilation-perfusion matching in the lung. Abnormal values of nasal NO (nNO) have been reported in different pathological conditions of the respiratory tract. Reduced nNO values have been recorded in subjects with acute and chronic sinusitis, cystic fibrosis and nasal pol

APA, Harvard, Vancouver, ISO, and other styles

8

Gridina, Anna, Xiaoyu Su, Shakil A. Khan, et al. "Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells." Journal of Neurophysiology 125, no. 5 (2021): 1533–42. http://dx.doi.org/10.1152/jn.00669.2020.

Full text

Abstract:

Catecholamine secretion from adrenal chromaffin cells is an important physiological mechanism for maintaining homeostasis during hypoxia. Here, we delineate carbon monoxide (CO)-sensitive hydrogen sulfide (H2S) signaling as an important mediator of hypoxia-induced catecholamine secretion from murine adrenal chromaffin cells. Heme oxygenase-2 derived CO is a physiological inhibitor of catcholamince secretion by hypoxia and the effects of CO involve inhibition of cystathionine γ-lyase-derived H2S production through soluble guanylyl cyclase-protein kinase G signaling cascade.

APA, Harvard, Vancouver, ISO, and other styles

9

Kim, Daekeun, Youngyu Choi, and Muthuraman Govindan. "An Electro-Reductive Removal of Gaseous Toluene By a Copper-Nickel Complex Mediator at Gas-to-Solid Interface." ECS Meeting Abstracts MA2022-01, no. 25 (2022): 1223. http://dx.doi.org/10.1149/ma2022-01251223mtgabs.

Full text

Abstract:

Electrochemical technique is one of the most promising methods for the removal of volatile organic compounds such as toluene. However, the conventional gas electrolysis method has mass transfer limitation, and the homogeneous catalysts are often irrecoverable after the reaction is completed, which leads to inefficient, less environmental-friendly, and uneconomical performance. This study proposes a gas-to-solid electrolysis system employing an electrode coated with heterogenous catalyst as the electron transfer mediator. A CuNi(CN)4 complex was prepared according to a published method and drop

APA, Harvard, Vancouver, ISO, and other styles

10

Wilkie, Stephen E., Gillian Borland, Roderick N. Carter, Nicholas M. Morton, and Colin Selman. "Hydrogen sulfide in ageing, longevity and disease." Biochemical Journal 478, no. 19 (2021): 3485–504. http://dx.doi.org/10.1042/bcj20210517.

Full text

Abstract:

Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major ch

APA, Harvard, Vancouver, ISO, and other styles

11

Inoue, Ken-ichiro, Hirohisa Takano, Akinori Shimada, and Masahiko Satoh. "Metallothionein as an Anti-Inflammatory Mediator." Mediators of Inflammation 2009 (2009): 1–7. http://dx.doi.org/10.1155/2009/101659.

Full text

Abstract:

The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological mediators. The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet. MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of

APA, Harvard, Vancouver, ISO, and other styles

12

Zaborova, Victoria, Elena Budanova, Kira Kryuchkova, et al. "Nitric oxide: a gas transmitter in healthy and diseased skin." Medical Gas Research 15, no. 4 (2025): 520–28. https://doi.org/10.4103/mgr.medgasres-d-24-00144.

Full text

Abstract:

Numerous physiological processes in the human skin are mediated by nitric oxide, a gaseous signalling molecule. Almost every type of skin cell may produce nitric oxide, it is possible to generate nitric oxide without the need of enzymes. Nitric oxide plays a crucial role in regulating apoptosis, keratinocyte differentiation and proliferation, the protective properties of the epidermal barrier, and the structure and functions of the microcirculatory bed. Nitric oxide is involved in immunological and inflammatory responses, hair growth regulation, and wound healing processes. It mediates ultravi

APA, Harvard, Vancouver, ISO, and other styles

13

Leffler, Charles W., Helena Parfenova, Jonathan H. Jaggar, and Rui Wang. "Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation." Journal of Applied Physiology 100, no. 3 (2006): 1065–76. http://dx.doi.org/10.1152/japplphysiol.00793.2005.

Full text

Abstract:

This review focuses on two gaseous cellular messenger molecules, CO and H2S, that are involved in cerebrovascular flow regulation. CO is a dilatory mediator in active hyperemia, autoregulation, hypoxic dilation, and counteracting vasoconstriction. It is produced from heme by a constitutively expressed enzyme [heme oxygenase (HO)-2] expressed highly in the brain and by an inducible enzyme (HO-1). CO production is regulated by controlling substrate availability, HO-2 catalytic activity, and HO-1 expression. CO dilates arterioles by binding to heme that is bound to large-conductance Ca2+-activate

APA, Harvard, Vancouver, ISO, and other styles

14

Martinez-Cutillas, M., V. Gil, N. Mañé, et al. "Potential role of the gaseous mediator hydrogen sulphide (H2S) in inhibition of human colonic contractility." Pharmacological Research 93 (March 2015): 52–63. http://dx.doi.org/10.1016/j.phrs.2015.01.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Xiao, Qing, Lidan Xiong, Jie Tang, Li Li, and Li Li. "Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target." Oxidative Medicine and Cellular Longevity 2021 (April 20, 2021): 1–11. http://dx.doi.org/10.1155/2021/6652086.

Full text

Abstract:

Together with nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) is now recognized as a vital gaseous transmitter. The ubiquitous distributions of H2S-producing enzymes and potent chemical reactivities of H2S in biological systems make H2S unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, H2S can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. The aberrant metabolism of H2S is involved in the pathogenesis of several sk

APA, Harvard, Vancouver, ISO, and other styles

16

Whiteman, Matthew, Sophie Le Trionnaire, Mohit Chopra, Bridget Fox, and Jacqueline Whatmore. "Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools." Clinical Science 121, no. 11 (2011): 459–88. http://dx.doi.org/10.1042/cs20110267.

Full text

Abstract:

H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues. In a relatively short period of time, H2S has attracted substantial interest as an endogenous gaseous mediator and potential target for pharmacological manipulation. Studies in animals and humans have shown H2S to be involved in diverse physiological and pathophysiological processes, such as learning and memory, neurodegeneration, regulation of inflammation and blood pressure, and metabolism. However, research is limited by the lack of specific analytical a

APA, Harvard, Vancouver, ISO, and other styles

17

Ying, Zanyun, Han Chen, Zheng He, et al. "Redox mediator-regulated microbial electrolysis cell to boost coulombic efficiency and degradation activity during gaseous chlorobenzene abatement." Journal of Power Sources 528 (April 2022): 231214. http://dx.doi.org/10.1016/j.jpowsour.2022.231214.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

gallego, d., p. clavé, j. donovan, et al. "The gaseous mediator, hydrogen sulphide, inhibitsin vitromotor patterns in the human, rat and mouse colon and jejunum." Neurogastroenterology & Motility 20, no. 12 (2008): 1306–16. http://dx.doi.org/10.1111/j.1365-2982.2008.01201.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Zhu, Zhixing, Xihua Lian, and Madhav Bhatia. "Hydrogen Sulfide: A Gaseous Mediator and Its Key Role in Programmed Cell Death, Oxidative Stress, Inflammation and Pulmonary Disease." Antioxidants 11, no. 11 (2022): 2162. http://dx.doi.org/10.3390/antiox11112162.

Full text

Abstract:

Hydrogen sulfide (H2S) has been acknowledged as a novel gaseous mediator. The metabolism of H2S in mammals is tightly controlled and is mainly achieved by many physiological reactions catalyzed by a suite of enzymes. Although the precise actions of H2S in regulating programmed cell death, oxidative stress and inflammation are yet to be fully understood, it is becoming increasingly clear that H2S is extensively involved in these crucial processes. Since programmed cell death, oxidative stress and inflammation have been demonstrated as three important mechanisms participating in the pathogenesis

APA, Harvard, Vancouver, ISO, and other styles

20

Wang, Xiaoyi, Hongyi Wen, Andrey Suprun, and Hongliang Zhu. "Ethylene Signaling in Regulating Plant Growth, Development, and Stress Responses." Plants 14, no. 3 (2025): 309. https://doi.org/10.3390/plants14030309.

Full text

Abstract:

Ethylene is a gaseous plant hormone that plays a crucial role in coordinating various physiological processes in plants. It acts as a key mediator, integrating both endogenous developmental cues and external environmental signals to regulate a wide range of functions, including growth, fruit ripening, leaf abscission, and responses to stress. The signaling pathway is initiated when ethylene binds to its receptor. After decades of research, the key components of ethylene signaling have been identified and characterized. Although the molecular mechanisms of the sensing of ethylene signal and its

APA, Harvard, Vancouver, ISO, and other styles

21

Chen, Han, Yanan Yu, Yu Yu, Jiexu Ye, Shihan Zhang, and Jianmeng Chen. "Exogenous electron transfer mediator enhancing gaseous toluene degradation in a microbial fuel cell: Performance and electron transfer mechanism." Chemosphere 282 (November 2021): 131028. http://dx.doi.org/10.1016/j.chemosphere.2021.131028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Whiteman, Matthew, and Jan-Thorsten Schantz. "Inducible Synthesis of the Gaseous Mediator Hydrogen Sulfide (H2S) by Human Resident Joint Cells and BoneDerived Mesenchymal Progenitor Cells." Free Radical Biology and Medicine 49 (January 2010): S150—S151. http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.424.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Liu, Yi-Hong, and Jin-Song Bian. "Bicarbonate-dependent effect of hydrogen sulfide on vascular contractility in rat aortic rings." American Journal of Physiology-Cell Physiology 299, no. 4 (2010): C866—C872. http://dx.doi.org/10.1152/ajpcell.00105.2010.

Full text

Abstract:

Hydrogen sulfide (H2S), an endogenous gaseous mediator, produces both vasorelaxation and vasoconstriction at different concentrations. We found in the present study that NaHS, an H2S donor, produced stronger vasorelaxant and weaker vasoconstrictive effects in HEPES solution compared with those achieved in Krebs solution. We further screened the buffer components and found that bicarbonate (HCO3−) was the ion to influence the effect of H2S. After examining the vasorelaxant effects of acetylcholine, a vasodilator by releasing nitric oxide, and isoprenaline, a β-adrenoceptor agonist, in HEPES and

APA, Harvard, Vancouver, ISO, and other styles

24

Zuhra, Karim, Fiona Augsburger, Tomas Majtan та Csaba Szabo. "Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition". Biomolecules 10, № 5 (2020): 697. http://dx.doi.org/10.3390/biom10050697.

Full text

Abstract:

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with multiple regulatory roles in the vascular, nervous, and immune system. CBS is up-regulated in several diseases, including Down syndrome and many forms of cancer; in these conditions, the preclinical data indicat

APA, Harvard, Vancouver, ISO, and other styles

25

Shen, Yaqi, Zhuqing Shen, Shanshan Luo, Wei Guo, and Yi Zhun Zhu. "The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/925167.

Full text

Abstract:

Hydrogen sulfide (H2S) is now recognized as a third gaseous mediator along with nitric oxide (NO) and carbon monoxide (CO), though it was originally considered as a malodorous and toxic gas. H2S is produced endogenously from cysteine by three enzymes in mammalian tissues. An increasing body of evidence suggests the involvement of H2S in different physiological and pathological processes. Recent studies have shown that H2S has the potential to protect the heart against myocardial infarction, arrhythmia, hypertrophy, fibrosis, ischemia-reperfusion injury, and heart failure. Some mechanisms, such

APA, Harvard, Vancouver, ISO, and other styles

26

Han, Na-Ra, Seong-Gyu Ko, Hi-Joon Park та Phil-Dong Moon. "Hydrogen Sulfide Downregulates Oncostatin M Expression via PI3K/Akt/NF-κB Signaling Processes in Neutrophil-like Differentiated HL-60 Cells". Antioxidants 12, № 2 (2023): 417. http://dx.doi.org/10.3390/antiox12020417.

Full text

Abstract:

The cytokine oncostatin M (OSM) is regarded as a critical mediator in various inflammatory responses. While the gaseous signaling molecule hydrogen sulfide (H2S) plays a role in a variety of pathophysiological conditions, such as hypertension, inflammatory pain, osteoarthritis, ischemic stroke, oxidative stress, retinal degeneration, and inflammatory responses, the underlying mechanism of H2S action on OSM expression in neutrophils needs to be clarified. In this work, we studied how H2S reduces OSM expression in neutrophil-like differentiated (d)HL-60 cells. To evaluate the effects of H2S, sod

APA, Harvard, Vancouver, ISO, and other styles

27

Li, Hui, Yinghong Ma, Oliver Escaffre, et al. "Role of Hydrogen Sulfide in Paramyxovirus Infections." Journal of Virology 89, no. 10 (2015): 5557–68. http://dx.doi.org/10.1128/jvi.00264-15.

Full text

Abstract:

ABSTRACTHydrogen sulfide (H2S) is an endogenous gaseous mediator that has gained increasing recognition as an important player in modulating acute and chronic inflammatory diseases. However, its role in virus-induced lung inflammation is currently unknown. Respiratory syncytial virus (RSV) is a major cause of upper and lower respiratory tract infections in children for which no vaccine or effective treatment is available. Using the slow-releasing H2S donor GYY4137 and propargylglycin (PAG), an inhibitor of cystathionine-γ-lyase (CSE), a key enzyme that produces intracellular H2S, we found that

APA, Harvard, Vancouver, ISO, and other styles

28

Basuroy, Shyamali, Dilyara Tcheranova, Sujoy Bhattacharya, Charles W. Leffler та Helena Parfenova. "Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis". American Journal of Physiology-Cell Physiology 300, № 2 (2011): C256—C265. http://dx.doi.org/10.1152/ajpcell.00272.2010.

Full text

Abstract:

We investigated the role of reactive oxygen species (ROS) in promoting cell survival during oxidative stress induced by the inflammatory mediator tumor necrosis factor-α (TNF-α) in cerebral microvascular endothelial cells (CMVEC) from newborn piglets. Nox4 is the major isoform of NADPH oxidase responsible for TNF-α-induced oxidative stress and apoptosis in CMVEC. We present novel data that Nox4 NADPH oxidase-derived ROS also initiate a cell survival mechanism by increasing production of a gaseous antioxidant mediator carbon monoxide (CO) by constitutive heme oxygenase-2 (HO-2). TNF-α rapidly e

APA, Harvard, Vancouver, ISO, and other styles

29

Mucha, Olga, Małgorzata Myszka, Paulina Podkalicka, et al. "Proteome Profiling of the Dystrophic mdx Mice Diaphragm." Biomolecules 13, no. 11 (2023): 1648. http://dx.doi.org/10.3390/biom13111648.

Full text

Abstract:

Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD). The disease, caused by the lack of functional dystrophin, is characterized by irreversible impairment of muscle functions, with the diaphragm affected earlier and more severely than other skeletal muscles. We applied a label-free (LF) method and the more thorough tandem mass tag (TMT)-based method to analyze differentially expressed proteins in the diaphragm of 6-week-old mdx mice. The comparison of both methods revealed 88 com

APA, Harvard, Vancouver, ISO, and other styles

30

Sulaieva, O. N., and J. L. Wallace. "Trends in development of gi-safe anti-inflammatory drugs." Clinical Medicine (Russian Journal) 95, no. 3 (2017): 222–27. http://dx.doi.org/10.18821/0023-2149-2017-95-3-222-227.

Full text

Abstract:

Despite the introduction of anti-inflammatory drugs that selectively inhibit cyclo-oxygenase-2 (COX-2), and potent inhibitors of gastric acid secretion, the gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) remain a significant clinical problem. Combined use of antisecretory drugs and COX-2 inhibitors is helpful to limit the damage in the proximal gastrointestinal tract (stomach and duodenum), but it increases the risk of injury of small intestine and colon. It was proven that proton pump inhibitors and H2 receptor antagonists significantly worsen NSAID-induced

APA, Harvard, Vancouver, ISO, and other styles

31

Panagaki, Theodora, Elisa B. Randi, and Csaba Szabo. "Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts." Biomolecules 10, no. 4 (2020): 653. http://dx.doi.org/10.3390/biom10040653.

Full text

Abstract:

Down syndrome (trisomy of human chromosome 21) is a common genetic disorder. Overproduction of the gaseous mediator hydrogen sulfide (H2S) has been implicated in the pathogenesis of neurological and metabolic deficits associated with Down syndrome. Several lines of data indicate that an important enzyme responsible for H2S overproduction in Down syndrome is cystathionine-β-synthase (CBS), an enzyme localized on chromosome 21. The current study explored the possibility that a second H2S-producing enzyme, 3-mercaptopyruvate sulfurtransferase (3-MST), may also contribute to the development of fun

APA, Harvard, Vancouver, ISO, and other styles

32

CHOWDHARY, Saqib, and Jonathan N. TOWNEND. "Role of nitric oxide in the regulation of cardiovascular autonomic control." Clinical Science 97, no. 1 (1999): 5–17. http://dx.doi.org/10.1042/cs0970005.

Full text

Abstract:

Alteration in function of the cardiac autonomic nervous system has proved to be a powerful predictor of cardiac death or serious arrhythmia in patients with cardiac disease, yet little is known about the mechanisms by which this system is regulated. Recent evidence suggests that the gaseous molecule nitric oxide (NO) may act as an important mediator in this pathway. Histochemical staining techniques have identified neuronal populations that contain NO synthase within medullary cardio-regulatory sites and their peripheral autonomic pathways. Drugs that modulate the NO pathway (administered both

APA, Harvard, Vancouver, ISO, and other styles

33

Andruski, Benjamin, Donna-Marie McCafferty, Teegan Ignacy, Brandie Millen, and Jason J. McDougall. "Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 3 (2008): R814—R820. http://dx.doi.org/10.1152/ajpregu.90524.2008.

Full text

Abstract:

Hydrogen sulfide (H2S) is an endogenous gaseous mediator with the ability to modulate tissue inflammation and pain. The aim of this study was to determine the effect of an H2S donor (Na2S) on leukocyte-endothelium interactions, blood flow, and pain sensation in acutely inflamed knee joints. Acute arthritis was induced in urethane anesthetized C57bl/6 mice by intra-articular injection of kaolin/carrageenan (24-h recovery), and the effect of local administration of Na2S on leukocyte trafficking was measured by intravital microscopy. Synovial blood flow was measured in inflamed knees by laser Dop

APA, Harvard, Vancouver, ISO, and other styles

34

Chan, Melissa V., and John L. Wallace. "Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 7 (2013): G467—G473. http://dx.doi.org/10.1152/ajpgi.00169.2013.

Full text

Abstract:

Hydrogen sulfide (H2S) is a gaseous meditator that has various physiological and pathophysiological roles in the body. It has been shown to be an important mediator of gastrointestinal (GI) mucosal defense and contributes significantly to repair of damage and resolution of inflammation. Synthesis of H2S increases markedly after mucosal injury, and inhibition of H2S in such circumstances leads to delayed healing and exacerbated inflammation. The beneficial effects of H2S may be attributable to its ability to elevate mucosal blood flow, prevent leukocyte-endothelial adhesion, reduce oxidative st

APA, Harvard, Vancouver, ISO, and other styles

35

Mostafa, Dalia K., Nesrine M. El Azhary, and Rasha A. Nasra. "The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine." Canadian Journal of Physiology and Pharmacology 94, no. 7 (2016): 699–708. http://dx.doi.org/10.1139/cjpp-2015-0316.

Full text

Abstract:

Hydrogen sulfide (H2S) has attracted interest as a gaseous mediator involved in diverse processes in the nervous system, particularly with respect to learning and memory. However, its therapeutic potential in Alzheimer disease (AD) is not fully explored. Therefore, the effects of H2S-releasing compounds against AD-like behavioural and biochemical abnormalities were investigated. Memory deficit was induced by intracerberoventicular injection of streptozotocin (STZ, 3 mg·kg−1). Animals were randomly assigned into 5 groups (12 rats each): normal control, STZ treated, and 3 drug-treated groups rec

APA, Harvard, Vancouver, ISO, and other styles

36

Hristov, Milen, and Pavlina Andreeva-Gateva. "Effects of simultaneous pharmacological inhibition of cystathionine gamma-lyase and nitric oxide synthase on food and water intake, body mass gain, and body temperature in rats." Journal of Biomedical and Clinical Research 17 (June 20, 2024): 133–42. https://doi.org/10.3897/jbcr.e122925.

Full text

Abstract:

Various studies have emphasized the intricate relationship between hydrogen sulfide (H<sub>2</sub>S) and nitric oxide (NO) in regulating diverse physiological processes. In this investigation, we aimed to elucidate the effects of simultaneous inhibition of the H<sub>2</sub>S-producing enzyme cystathionine γ-lyase and the NO-producing enzyme nitric oxide synthase on food and water intake, body mass gain and body temperature in rats. Specifically, we explored the combined impact of dl-propargylglycine, an irreversible inhibitor of cystathionine γ-lyase, and Nω-Nitro-L-arginine

APA, Harvard, Vancouver, ISO, and other styles

37

Ou, Xuelan, Tianqin Xia, Chunyan Yang та ін. "Novel H2S donor proglumide-ADT-OH protects HUVECs from ox-LDL-induced injury through NF-κB and JAK/SATA pathway". Open Medicine 16, № 1 (2021): 1318–27. http://dx.doi.org/10.1515/med-2021-0287.

Full text

Abstract:

Abstract As a gaseous mediator, hydrogen sulfide (H2S) has many physiological effects and pathological effects in atherosclerosis. In recent years, many exogenous H2S donors have been synthesized to study atherosclerosis diseases. In this study, proglumide-(5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) (P-A) was synthesized as a H2S donor. The protective effect and mechanism of P-A on HUVEC that was injured by ox-LDL were detected. The HUEVCs were affected by 100 μmol/L P-A for 24 h; the release of H2S was the largest. After 100 μmol/L P-A acted on HUVEC damage model for 12 h, the cell prolife

APA, Harvard, Vancouver, ISO, and other styles

38

Szabo, Csaba. "Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications." American Journal of Physiology-Cell Physiology 312, no. 1 (2017): C3—C15. http://dx.doi.org/10.1152/ajpcell.00282.2016.

Full text

Abstract:

Nitric oxide (NO) vascular signaling has long been considered an independent, self-sufficient pathway. However, recent data indicate that the novel gaseous mediator, hydrogen sulfide (H2S), serves as an essential enhancer of vascular NO signaling. The current article overviews the multiple levels at which this enhancement takes place. The first level of interaction relates to the formation of biologically active hybrid S/N species and the H2S-induced stimulation of NO release from its various stable “pools” (e.g., nitrite). The next interactions occur on the level of endothelial calcium mobili

APA, Harvard, Vancouver, ISO, and other styles

39

O, Karmin, and Yaw L. Siow. "Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease." Current Medicinal Chemistry 25, no. 3 (2018): 367–77. http://dx.doi.org/10.2174/0929867324666170509145240.

Full text

Abstract:

Homocysteine (Hcy) and hydrogen sulfide (H2S) are important molecules produced during the metabolism of sulfur-containing amino acids. Hcy metabolism is central to the supply of methyl groups that are essential for biological function. Hcy can be either regenerated to methionine or metabolized to cysteine, a precursor for glutathione synthesis. Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway. These two enzymes are also responsible for H2S generation through desulfuration reactions. H2S, at p

APA, Harvard, Vancouver, ISO, and other styles

40

Sobko, Tanja, Claudia Reinders, Elisabeth Norin, Tore Midtvedt, Lars E. Gustafsson, and Jon O. Lundberg. "Gastrointestinal nitric oxide generation in germ-free and conventional rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 5 (2004): G993—G997. http://dx.doi.org/10.1152/ajpgi.00203.2004.

Full text

Abstract:

Nitric oxide (NO) is a central mediator of various physiological events in the gastrointestinal tract. The influence of the intestinal microflora for NO production in the gut is unknown. Bacteria could contribute to this production either by stimulating the mucosa to produce NO, or they could generate NO themselves. Using germ-free and conventional rats, we measured gaseous NO directly in the gastrointestinal tract and from the luminal contents using a chemiluminescence technique. Mucosal NO production was studied by using an NO synthase (NOS) inhibitor, and to evaluate microbial contribution

APA, Harvard, Vancouver, ISO, and other styles

41

Kang, Minho, Atsushi Hashimoto, Aravind Gade, and Hamid I. Akbarali. "Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex." American Journal of Physiology-Gastrointestinal and Liver Physiology 308, no. 6 (2015): G532—G539. http://dx.doi.org/10.1152/ajpgi.00281.2014.

Full text

Abstract:

Hydrogen sulfide (H2S) is an endogenous gaseous mediator affecting many physiological and pathophysiological conditions. Enhanced expression of H2S and reactive nitrogen/oxygen species (RNS/ROS) during inflammation alters cellular excitability via modulation of ion channel function. Sulfhydration of cysteine residues and tyrosine nitration are the posttranslational modifications induced by H2S and RNS, respectively. The objective of this study was to define the interaction between tyrosine nitration and cysteine sulfhydration within the ATP-sensitive K+ (KATP) channel complex, a significant ta

APA, Harvard, Vancouver, ISO, and other styles

42

Xue, Xiuling, Xiaoyi Chen, and Xiuwen Gong. "Fast electron transfer and enhanced visible light photocatalytic activity of silver and Ag2O co-doped titanium dioxide with the doping of electron mediator for removing gaseous toluene." Materials Science in Semiconductor Processing 132 (September 2021): 105901. http://dx.doi.org/10.1016/j.mssp.2021.105901.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Ryter, Stefan. "Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders." Antioxidants 9, no. 11 (2020): 1153. http://dx.doi.org/10.3390/antiox9111153.

Full text

Abstract:

Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase. HO-1 has been implicated as a cytoprotectant in various models of acute organ injury and disease (i.e., lung, kidney, heart, liver). Thus, HO-1 may serve as a general therapeutic target in inflammatory diseases. HO-1 may function as a pleiotropic modulator of inflammatory signaling, via the removal of heme, and generation of its enzymatic degradation-products. Iron r

APA, Harvard, Vancouver, ISO, and other styles

44

Leffler, Charles W., Helena Parfenova, and Jonathan H. Jaggar. "Carbon monoxide as an endogenous vascular modulator." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 1 (2011): H1—H11. http://dx.doi.org/10.1152/ajpheart.00230.2011.

Full text

Abstract:

Carbon monoxide (CO) is produced by heme oxygenase (HO)-catalyzed heme degradation to CO, iron, and biliverdin. HO has two active isoforms, HO-1 (inducible) and HO-2 (constitutive). HO-2, but not HO-1, is highly expressed in endothelial and smooth muscle cells and in adjacent astrocytes in the brain. HO-1 is expressed basally only in the spleen and liver but can be induced to a varying extent in most tissues. Elevating heme, protein phosphorylation, Ca2+ influx, and Ca2+/calmodulin-dependent processes increase HO-2 activity. CO dilates cerebral arterioles and may constrict or dilate skeletal m

APA, Harvard, Vancouver, ISO, and other styles

45

Sakaguchi, Masahiro, Eizo Marutani, Hae-sook Shin, et al. "Sodium Thiosulfate Attenuates Acute Lung Injury in Mice." Anesthesiology 121, no. 6 (2014): 1248–57. http://dx.doi.org/10.1097/aln.0000000000000456.

Full text

Abstract:

Abstract Background: Acute lung injury is characterized by neutrophilic inflammation and increased lung permeability. Thiosulfate is a stable metabolite of hydrogen sulfide, a gaseous mediator that exerts antiinflammatory effects. Although sodium thiosulfate (STS) has been used as an antidote, the effect of STS on acute lung injury is unknown. The authors assessed the effects of STS on mice lung and vascular endothelial cells subjected to acute inflammation. Methods: Lung injury was assessed in mice challenged with intratracheal lipopolysaccharide or subjected to cecal ligation and puncture wi

APA, Harvard, Vancouver, ISO, and other styles

46

Zhou, Ye-Bo, Hong Zhou, Li Li, et al. "Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway." International Journal of Molecular Sciences 20, no. 17 (2019): 4202. http://dx.doi.org/10.3390/ijms20174202.

Full text

Abstract:

Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes the osteogenic transformation of smooth muscle cells (SMCs) and involves arterial medial calcification (AMC) that is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes. Here, we tested whether hydrogen sulfide (H2S), an endogenous gaseous mediator, can prevent elastin loss and attenuate calcification induced by high glucose in SMCs. Calcification was induced by high glucose (4500 mg/L) in human aortic SMCs (HASMCs) under the condition of calcifying medium contain

APA, Harvard, Vancouver, ISO, and other styles

47

Sklyarova, Yu O., and I. S. Fomenko. "ACTION OF HYDROGEN SULFIDE DONORS ON NITROSO-OXIDATIVE PROCESSES IN SMALL INTESTINE OF RATS WITH METHOTREXATE-INDUCED ENTEROPATHY." Medical and Clinical Chemistry, no. 3 (November 7, 2018): 50–56. http://dx.doi.org/10.11603/mcch.2410-681x.2018.v0.i3.9565.

Full text

Abstract:

Introduction. Medication-induced enteropathy plays an important part among factors leading to the development of small intestinal injury. There are some evidences indicating a potential preventive action of hydrogen sulfide (H2S) donors against drug-induced enteropathies based on that fact that the use of the most of enterotoxic medications including anti-tumor drugs leads to the suppression of this gaseous mediator production.  The aim of the study – to compare the action of H2S donors in small intestine of rats on parameters of NO-synthase system and oxidative stress under condition of

APA, Harvard, Vancouver, ISO, and other styles

48

Myśliwiec, Angelika, Dorota Bartusik-Aebisher, and David Aebisher. "The Role of Nitric Oxide in Cancer Treatment: Ally or Foe?" Molecules 30, no. 13 (2025): 2802. https://doi.org/10.3390/molecules30132802.

Full text

Abstract:

Nitric oxide (NO), the first gaseous molecule identified as a signaling mediator, plays a pivotal role in numerous physiological processes including cardiovascular regulation, immune response, and neurotransmission. Synthesized from L-arginine by nitric oxide synthase (NOS), NO exerts both protective and cytotoxic effects depending on its local concentration. At low levels, NO supports tumor growth by mitigating oxidative stress, while at high concentrations, it induces apoptosis through mechanisms such as p53 activation, cytochrome c release, and peroxynitrite formation. These dual properties

APA, Harvard, Vancouver, ISO, and other styles

49

A. Sutherland, Brad, Joanne C. Harrison, Shiva M. Nair, and Ivan A. Sammut. "Inhalation Gases or Gaseous Mediators As Neuroprotectants for Cerebral Ischaemia." Current Drug Targets 14, no. 1 (2012): 56–73. http://dx.doi.org/10.2174/1389450111314010007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

A. Sutherland, Brad, Joanne C. Harrison, Shiva M. Nair, and Ivan A. Sammut. "Inhalation Gases or Gaseous Mediators As Neuroprotectants for Cerebral Ischaemia." Current Drug Targets 14, no. 1 (2013): 56–73. http://dx.doi.org/10.2174/138945013804806433.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!