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Journal articles on the topic 'Gastric mucosal erosion'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Hawkey, C. J., A. B. Hawthorne, N. Hudson, A. T. Cole, Y. R. Mahida, and T. K. Daneshmend. "Separation of the impairment of haemostasis by aspirin from mucosal injury in the human stomach." Clinical Science 81, s25 (1991): 565–73. http://dx.doi.org/10.1042/cs0810565.

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1. An increasing body of data suggests that the anti-haemostatic as well as the ulcerogenic actions of aspirin and other non-steroidal anti-inflammatory drugs may be operative when patients present with haematemesis and melaena. 2. We therefore developed methods to allow separate evaluation of the erosive and anti-haemostatic actions of aspirin in the human gastric mucosa. Volunteer subjects took 300 mg of aspirin daily in the morning or 600 mg of aspirin four times a day for 5 days under blinded randomized conditions. Changes in spontaneous gastric microbleeding, endoscopic signs of injury, s

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2

Al-Yassir, Farah, Ghalia Khoder, Subi Sugathan, Prashanth Saseedharan, Asma Al Menhali, and Sherif M. Karam. "Modulation of Stem Cell Progeny by Probiotics during Regeneration of Gastric Mucosal Erosions." Biology 10, no. 7 (2021): 596. http://dx.doi.org/10.3390/biology10070596.

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Patients with gastric mucosal erosions are predisposed to chronic gastritis, ulcer or even cancer. The repair of mucosal erosions involves several events including proliferation of gastric epithelial stem cells. The aim of this study was to investigate the effects of the probiotic mixture of De Simone Formulation on gastric epithelial stem cell lineages in mouse models of gastric mucosal erosions. Gastric erosions were induced by a single oral gavage of 80% ethanol containing 15 mg/mL acetylsalicylic acid (5 mL/kg) following a daily dose of probiotic mixture (5 mg/day/mouse) for 10 days. In an

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3

Shin, Heung Mook. "Anti-oxidative Herbs and Indomethacin-Induced Rat Gastric Mucosal Lesions: Protection by GamiHyangsa-Yukgunja." American Journal of Chinese Medicine 29, no. 01 (2001): 101–9. http://dx.doi.org/10.1142/s0192415x01000113.

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This study investigates the protective effects of GamiHyangsa-Yukgunja (GHY, a popular herbal medicine formula) on indomethacin-induced gastric mucosal lesions and morphological change in rats. Subcutaneous injection of indomethacin (25 mg/kg) produced the following gastric morphological alterations; mucosa hermorrhagic infarct, mucosa cell necrosis, leukocyte infiltration, mucosa hemorrhagic erosion, and gastric pit disappearance. Tissue damages were accompanied by increased oxidative stress, lipid peroxidation, and decreases in superoxide dismutase (SOD), and catalase (CAT) activities, and g

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4

Gao, Feng, Xue Chen, and Jie Zhang. "Prevalence of Gastric and Small-Intestinal Mucosal Injury in Elderly Patients Taking Enteric-Coated Aspirin by Magnetically Controlled Capsule Endoscopy." Gastroenterology Research and Practice 2019 (November 5, 2019): 1–5. http://dx.doi.org/10.1155/2019/1582590.

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Objective. To investigate aspirin-related gastric and small-intestinal mucosal injury in elderly patients by magnetically controlled capsule endoscopy (MCCE). Methods. Patients taking enteric-coated aspirin attending the outpatient department of Beijing Anzhen Hospital, Capital Medical University, from September 2017 to July 2019 underwent MCCE to assess injury to the gastric and small-intestinal mucosa. The patients were divided into the elderly group (age≥60 years) and middle-aged group (45 years≤age<60 years), and their clinical data were evaluated. Results. Sixty-eight patients (34 per

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5

Sacra, P., N. B. Roberts, and W. H. Taylor. "Production of Acute Gastric Erosions in the Cat by Individual Human Pepsins." Clinical Science 88, no. 1 (1995): 47–50. http://dx.doi.org/10.1042/cs0880047.

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1. Differing amounts of human pepsins 1, 3 (pepsin A) and 5 (pepsin C or gastriscin) in aqueous HCl/NaCl at pH 1.3 were placed in Perspex rings on the exposed luminal surface of the perfused cat stomach to test for mucolytic and erosive activity in vivo, with the acid medium in control rings. 2. After incubation at 37°C for 60 or 120 min, the test and control solutions were replaced by the same volume of each test or control solution containing 18 mg of aspirin and incubated for a further 120 min. 3. The number of bleeding points or erosions was counted at 15 min intervals. None was observed w

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6

Hashimoto, Rintaro, Toru Okuzono, and Junichi Akahira. "An Uncommon Gastric Submucosal Tumor With Mucosal Erosion." Clinical Gastroenterology and Hepatology 16, no. 5 (2018): e57-e58. http://dx.doi.org/10.1016/j.cgh.2017.06.003.

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7

Yang, Jie, Yue Yuan, Shu Zhang, and Ying Lv. "Gastric metastasis from pancreatic cancer characterized by mucosal erosion: a case report and literature review." Journal of International Medical Research 49, no. 4 (2021): 030006052110037. http://dx.doi.org/10.1177/03000605211003759.

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Pancreatic cancer with gastrointestinal tract metastasis is a fairly rare occurrence, and gastric metastasis in such cases has been seldom reported. We herein present a case of gastric involvement secondary to pancreatic cancer in a 74-year-old woman in whom the metastatic lesion only presented as mucosal erosion in the stomach. The patient had a 1-month history of progressive right upper quadrant pain before admission. Computed tomography and endoscopic examinations revealed a solid and hypo-enhancing mass in the head of the pancreas. The patient underwent conventional upper endoscopy before

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8

Joh, Takashi, Tadayuki Oshima, Nobuo Takahashi, et al. "Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 2 (2005): G230—G234. http://dx.doi.org/10.1152/ajpgi.00100.2004.

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Accumulating evidence suggests that central thyrotropin-releasing hormone (TRH) administration induces gastric erosion 4 h after administration through the vagal nerves. However, early changes in the gastric mucosa during these 4 h have not been described. To assess early changes in the gastric mucosa after intracisternal injection of a stable TRH analog, pGlu-His-(3,3′-dimethyl)-ProNH2 (RX-77368), we measured the blood-to-lumen 51Cr-labeled EDTA clearance and examined the effects of vagotomy, atropine, omeprazole, and hydrochloric acid (HCl) on RX-77368-induced mucosal permeability. A cytopro

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9

GOMES, Alexandre, Thelma Larocca SKARE, Manoel Alberto PRESTES, Maiza da Silva COSTA, Roberta Dombroski Petisco, and Gabriela Piovezani RAMOS. "CONVENTIONAL VIDEOENDOSCOPY CAN IDENTIFY HELICOBACTER PYLORI GASTRITIS?" ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 29, no. 2 (2016): 73–76. http://dx.doi.org/10.1590/0102-6720201600020002.

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ABSTRACT Background: Studies with latest technologies such as endoscopy with magnification and chromoendoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori (HP). The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. Aim: To validate the morphologic features of gastric mucosa related to H. pylori infection gastritis allowing predictability of their diagnosis as well as proper targeting biopsies. Methods: Prospective study of 339 consec

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10

Kim, Bomin, Beom Jin Kim, Hong Jip Yoon, et al. "Atypical Scar Patterns after Gastric Endoscopic Submucosal Dissection." Korean Journal of Helicobacter and Upper Gastrointestinal Research 21, no. 1 (2021): 72–81. http://dx.doi.org/10.7704/kjhugr.2020.0047.

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Background/Aims: Endoscopic submucosal dissection (ESD) for gastric neoplasms is a widely performed procedure. Local recurrence is rare, but various post-ESD scars are encountered during follow-up endoscopy. Therefore, we investigated atypical scar patterns and evaluated the associated factors.Materials and Methods: Clinicopathologic and endoscopic reviews of gastric neoplasms treated with ESD from January 2009 to December 2015 were conducted. Atypical scar patterns were classified as irregular erythema, nodularity, or mucosal defect.Results: A total of 264 patients with 274 gastric neoplasms,

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Lyra, Anna, Markku Saarinen, Heli Putaala, et al. "Bifidobacterium animalisssp.lactis420 Protects against Indomethacin-Induced Gastric Permeability in Rats." Gastroenterology Research and Practice 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/615051.

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Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whetherBifidobacterium animalisssp.lactis420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wistar rats were allocated into groups designated as control, NSAID, and probiotic. The NSAID and probiotic groups were challenged with indomethacin (10 mg/kg−1; single dose). The probiotic group was also supplemented daily with 1010 CFU ofB. lactis420 for seven days prior to the indome

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12

Kitagawa, Hisato, Kazuyoshi Kurahashi, and Motohatsu Fujiwara. "TXA2-like substance-induced gastric mucosal ischemia and mucosal erosion in water-immersion stress loaded rats." Japanese Journal of Pharmacology 40 (1986): 222. http://dx.doi.org/10.1016/s0021-5198(19)59413-6.

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13

Masuda, Shuichi, Hideki Masuda, Yuko Shimamura, Chitose Sugiyama, and Fumiyo Takabayashi. "Improvement Effects of Wasabi (Wasabia japonica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori." Natural Product Communications 12, no. 4 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200431.

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The relationship between Helicobacter pylori infection and gastric cancer associated with stomach lesions has been reported. Improvement of the adverse effects induced by H. pylori is required for human health. It has been reported that wasabi ( Wasabia japonica Matsum) leaves have various effects on bacteria and mammals. In this study, the effect was examined of wasabi leaf extract and allyl isothiocyanate (AIT), which is a main functional component of wasabi, on stomach lesions in Mongolian gerbils infected with H. pylori. After the gerbils infected with H. pylori were orally administrated w

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14

Yamamoto, Shunsuke, Kenji Watabe, Hiroshi Araki, et al. "Protective role of adiponectin against ethanol-induced gastric injury in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 8 (2012): G773—G780. http://dx.doi.org/10.1152/ajpgi.00324.2011.

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Adiponectin is an anti-inflammatory molecule released from adipocytes, and serum adiponectin concentrations are reduced in obesity. We previously reported that gastric erosion occurs in association with obesity and low serum adiponectin levels. In the present study, we examined adiponectin-knockout (APN-KO) mice to elucidate the role of adiponectin in gastric mucosal injury. Gastric injury was induced by oral administration of ethanol in wild-type (WT) and APN-KO mice. Ethanol treatment induced severe gastric injury in APN-KO mice compared with WT mice. In APN-KO mice, increased apoptotic cell

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15

He, Feng, Min Wang, Xiwen Geng, and Hongbin Ai. "Effect of Electroacupuncture on the Activity of Corticotrophin-Releasing Hormone Neurons in the Hypothalamus and Amygdala in Rats Exposed to Restraint Water-Immersion Stress." Acupuncture in Medicine 36, no. 6 (2018): 394–400. http://dx.doi.org/10.1136/acupmed-2017-011450.

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Objective To investigate the effects of electroacupuncture (EA) treatment on gastric mucosal lesions and the activity of corticotrophin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus and the central nucleus of the amygdala (CNA) in a rat model of restraint water-immersion stress (RWIS). Methods 24 male Wistar rats were randomly divided into three groups: normal, RWIS, and RWIS+EA (n=8 per group). Rats in the RWIS group and RWIS+EA group received RWIS for 3 hours. For rats in the RWIS+EA group, EA was applied at ST36 in the bilateral hind legs for 30 mi

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16

Boby, Naila, Muhammad Aleem Abbas, Eon-Bee Lee, Zi-Eum Im, Walter H. Hsu, and Seung-Chun Park. "Protective Effect of Pyrus ussuriensis Maxim. Extract against Ethanol-Induced Gastritis in Rats." Antioxidants 10, no. 3 (2021): 439. http://dx.doi.org/10.3390/antiox10030439.

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Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Pyrus ussuriensis Maxim extract (PUE) against ethanol-induced gastritis in rats. The bioactive compound profile of PUE was determined by gas chromatography mass spectroscopy (GC-MS) and high-performance liquid c

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17

Vera, Mariano Ezequiel, María Laura Mariani, Cristina Aguilera, and Alicia Beatriz Penissi. "Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation." International Journal of Molecular Sciences 22, no. 11 (2021): 5983. http://dx.doi.org/10.3390/ijms22115983.

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The aim of this study was to determine whether the lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one, would be effective in an animal model of gastric ulcer induced by mast cell activation. Rats were divided into ten groups. Treatments were repeated for four days. The degree of gastric erosion was assessed with a scoring system and histological preparations. Gastric mast cell morphology was analyzed by histological procedures. Serum serotonin levels were determined as markers of mast cell activation. Statistical analyses were done using ANOVA and Tukey–Kramer test. We d

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18

ISHIKAWA, HIDEKI, MASASHI YOSHIDA, GO WAKABAYASHI, MASAHIKO NAKAMURA, MOTOHIDE SHIMAZU, and MASAKI KITAJIMA. "Sialyl Lewis X analog attenuates gastric microcirculatory disturbance and gastric mucosal erosion induced by thermal injury in rats." Journal of Gastroenterology and Hepatology 18, no. 1 (2003): 47–52. http://dx.doi.org/10.1046/j.1440-1746.2003.02908.x.

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19

Şehirli, Özer, Elif Tatlıdede, Meral Yüksel, et al. "Antioxidant Effect of Alpha-Lipoic Acid against Ethanol-Induced Gastric Mucosal Erosion in Rats." Pharmacology 81, no. 2 (2007): 173–80. http://dx.doi.org/10.1159/000111145.

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20

Hao, Zheng-Kui, Xi-Shuang Liu, and Xiu-Juan Wang. "Expression of epidermal growth factor and epidermal growth factor receptor in gastric mucosal erosion." World Chinese Journal of Digestology 21, no. 4 (2013): 332. http://dx.doi.org/10.11569/wcjd.v21.i4.332.

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21

Akce, Mehmet, Sharon Bihlmeyer, and Andrew Catanzaro. "Multiple Gastric Metastases from Ovarian Carcinoma Diagnosed by Endoscopic Ultrasound with Fine Needle Aspiration." Case Reports in Gastrointestinal Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/610527.

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Metastasis to the stomach from nongastric tumors is a rare event. We present a case of ovarian cancer metastasis to the gastric wall that presented as multiple subepithelial gastric lesions. A 55-year-old female with known stage III b serous ovarian cancer was admitted to the hospital with melena and anemia. A 1.5 to 2 cm subepithelial mass with superficial overlying erosion in the antrum was seen in Esophagogastroduodenoscopy (EGD). Initial endoscopic mucosal biopsies were normal. An Endoscopic Ultrasound (EUS) was performed, which revealed two subepithelial lesions with the typical appearanc

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Kim, Su Jin, Cheol Woong Choi, and Dae Hwan Kang. "Endoscopic features of submucosal invasion in undifferentiated type early gastric cancer sized less than 2 cm without ulceration." Journal of Clinical Oncology 37, no. 4_suppl (2019): 76. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.76.

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76 Background: The prediction of invasion depth is important to decide the treatment modality for the undifferentiated type early gastric cancer (EGC) when size is less than 2 cm and had no ulceration. We aimed to identify the endoscopic features associated with submucosal invasion in the undifferentiated type EGC that meet the criteria of size and status of ulcer in the endoscopic submucosal dissection (ESD). Methods: A total of 120 patients with undifferentiated type EGC who received ESD or operation from August 2008 to December 2017 were enrolled in this study. All lesions met the ESD crite

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Hassan, Tareq M., Estrellita Ontiveros, Daniel Davis, and Steven G. Leeds. "Endoscopic Removal of Noneroded Nonadjustable Gastric Bands Using Induced Mucosal Erosion With a Stent, and Review of the Literature." Surgical Innovation 26, no. 2 (2018): 162–67. http://dx.doi.org/10.1177/1553350618820377.

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Background. Laparoscopic removal of noneroded nonadjustable gastric bands (NAGBs) may lead to major life-threatening complications. A minimally invasive approach involving endoscopic removal by induced mucosal erosion with a stent (IMES) has been used in a few publications to remove NAGBs. Objective. To examine a minimally invasive endoscopic approach to removal of a NAGB. Setting. A large tertiary/quaternary referral hospital. Methods. We report 4 patients that underwent IMES at our institution and present a literature review of published cases. The procedure includes using an endoscopically

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Patoulias, Ioannis, Christos Kaselas, Dimitrios Patoulias, et al. "Multiple Gastric Erosion Early after a 3 V Lithium Battery (CR2025) Ingestion in an 18-Month-Old Male Patient: Consideration about the Proper Time of Intervention." Case Reports in Pediatrics 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/3965393.

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Introduction. Button battery ingestion is considered an emergency situation in pediatric patients that needs to be managed promptly; otherwise, it may lead to serious and potentially lethal complications, especially when it is impacted in the esophagus. Less attention has been given in cases where the battery passes into the stomach, with guidelines for emergency intervention being based on the presence of symptoms. Case Report. We present a case of an 18-month-old male patient who presented to our emergency department after button battery ingestion. He did not have any symptoms and no patholo

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Mugo, Nancy W., Christine Wangia, Gideon Kikuvi, and Samuel Ngugi. "Antiulcerogenic effect of Capparis cartillaginea decne on indomethacin induced gastric ulcer in wistar rats." International Journal of Research in Medical Sciences 8, no. 10 (2020): 3445. http://dx.doi.org/10.18203/2320-6012.ijrms20204213.

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Background: Peptic ulcer disease is a non-malignant, mucosal lesion of the stomach or duodenum. The mucosal defect reaches the muscularis mucosa and sometimes, beyond causing life threatening complications, including haemorrhage, perforations, gastrointestinal obstruction and malignancy.Methods: The animals were pre-treated with omeprazole 20 mg/kg and 300 mg/kg of Capparis cartillaginea decne orally for 14 days. On the 15th day, ulcers were induced using indomethacin 30 mg/kg and 4 hours post ulcer induction, they were sacrificed. Ulcer index, pH, total acidity and volume were determined.Resu

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Landeira-Fernandez, Jesus, and Carlos V. Grijalva. "Gastric mucosal erosion produced by NMDA microinfusions in the lateral hypothalamus: effect of selective knife cuts." Behavioural Brain Research 102, no. 1-2 (1999): 51–60. http://dx.doi.org/10.1016/s0166-4328(98)00161-2.

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27

Obaia, Reem, Yakout Elsenosi, Mohamed Mahfouz, and Samy Aziza. "Proanthocyanidin ameliorates against ethanol -induced gastric mucosal erosion by attenuating inflammatory response, oxidative stress and apoptosis in rats." Benha Veterinary Medical Journal 38, no. 1 (2020): 1–8. http://dx.doi.org/10.21608/bvmj.2020.22277.1151.

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László, F., I. Pávó, B. Penke, and G. A. Bálint. "The effects of somatostatin and some of its tetrapeptide fragments on ethanol-induced gastric mucosal erosion in rat." Life Sciences 41, no. 9 (1987): 1123–26. http://dx.doi.org/10.1016/0024-3205(87)90630-8.

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Lim, Huei-Wen, Benny Yiu Wong, David Elkowitz, and Keith Sultan. "An elderly patient’s complete response to steroid therapy for collagenous gastritis." Therapeutic Advances in Chronic Disease 9, no. 8 (2018): 143–46. http://dx.doi.org/10.1177/2040622318759628.

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An 85-year-old woman presented with 9.1 kg (20 lb) weight loss over 5 months and an acute onset crampy abdominal pain. Examination revealed a diffusely tender abdomen, with gastric wall thickening noted on CT scan. Upper endoscopy showed diffuse severe erythema and friability. Histologic examination with hematoxylin and eosin staining revealed collagenous gastritis characterized by active chronic inflammation with sub-epithelial collagen deposition and erosion. The patient was started on steroid therapy with rapid clinical improvement and tapered off over 2.5 months. At 6 months, the patient r

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AbdullGaffar, Badr, and Hoda Quraishi. "Histopathologic Manifestations of Crohn Disease in Duodenal Endoscopy Biopsy: The Value of Different Patterns of Involvement of Brunner Glands." International Journal of Surgical Pathology 29, no. 7 (2021): 710–15. http://dx.doi.org/10.1177/1066896921998438.

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Crohn disease (CD) not uncommonly involves the upper gastrointestinal tract, usually gastric antrum and proximal duodenum. The most consistent histopathologic manifestations of CD in duodenal biopsies are mucosal erosion, focal active inflammation, and granulomas. Since CD is a transmural inflammation and since duodenal biopsy may include submucosal Brunner glands, we aimed to find if CD has any specific histopathologic manifestations in Brunner gland lobules and their ducts compared to other duodenal inflammatory lesions. We carried out a retrospective review study over 6 years retrieving duo

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Duan, Lei, Man Li, Fan Wang, et al. "Increased Risk of Clopidogrel-Induced Gastric Mucosal Erosion in Elderly Chinese Men Harboring the ABCB1 3435T Allele." Risk Management and Healthcare Policy Volume 13 (August 2020): 1237–44. http://dx.doi.org/10.2147/rmhp.s263625.

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Espitia, Francisco Terrazas, David Molina Dávila, Alberto Manuel González Chávez, José Manuel Gómez López, and Louis Francois De Giau Triulzi. "Right hepatic artery injury: an unusual complication of penetrated duodenal ulcer disease." International Surgery Journal 4, no. 6 (2017): 2063. http://dx.doi.org/10.18203/2349-2902.isj20172413.

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Peptic ulcers generally appear in the stomach and the first segment of the duodenum as a result of mucosal erosion caused by pepsin and gastric acid secretion, with up to 70% of these occurring amongst patients aged 25-64. Currently, endoscopic procedures combined with proton pump inhibitors are considered the gold standard for managing complicated peptic ulcers, leaving surgical management as an option for endoscopic management failure or in scenarios such as incoercible bleeding, perforation, penetration and intestinal occlusion. Penetration of a gastric ulcer to adjacent organs is a rare co

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Saroj, Jitendra Kumar, Arshad Ahmad, Pankaj Kumar, and Sandeep Verma. "Jejunal perforation secondary to trichobezoar (Rapunzel syndrome): a rare presentation." International Surgery Journal 6, no. 8 (2019): 3002. http://dx.doi.org/10.18203/2349-2902.isj20193360.

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Trichobezoar is a rare disorder. It usually occurs in young and adolescent females associated with some psychiatric illness. Trichobezoar usually accumulate in the GI tract and most commonly in stomach but it can migrate through the pylorus into the jejunum, ileum and colon. Once the bezoars extends from the stomach into the jejunum or further on, it is referred to as “Rapunzel syndrome”. Though initially asymptomatic but over a period of time it may cause gastric mucosal erosion, ulceration, and perforation of the stomach or the small intestine. If unrecognized, tichobezoar may present with i

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Geraghty, J. G., W. J. Angerson, and D. C. Carter. "Erosive Gastritis and Portal Hypertension." HPB Surgery 6, no. 1 (1992): 19–22. http://dx.doi.org/10.1155/1992/34720.

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There is conflicting evidence concerning the effects of portal hypertension on the gastric mucosa. This paper summarises the histological and haemodynamic alterations which are present in both human and experimental portal hypertension. Despite the fact that histological studies suggests that the gastric mucosa is an oedematous plethoric structure in portal hypertension, haemodynamic studies show that gastric mucosal blood glow is at least maintained if not increased in portal hypertension. The term “active” rather than “passive” congestion is a more appropriate description of the basic change

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Rai, Uddipak, Ashok Kumar Pattnaik, and Sanjay Singh. "ANTIULCER ACTIVITY OF THE MOST ACTIVE SUB-FRACTION OF METHANOLIC LEAF EXTRACT OF BUCHANANIA LANZAN SPRENG." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 93. http://dx.doi.org/10.22159/ijpps.2016.v8i9.12074.

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<p><strong>Objective: </strong>To evaluate the antiulcer<strong> </strong>activity of the most active sub-fraction of <em>Buchanania lanzan</em> Spreng. leaves methanolic extract (BLE).</p><p><strong>Methods: </strong>The antioxidant activity of BLE fractions and sub-fractions has been assayed to determine the most active sub-fraction by using <em>in vitro </em>antioxidant<em> </em>methods like hydrogen peroxide free radical scavenging assay, hydroxyl radical scavenging assay, DPPH (1, 1-diphenyl-2-picryl

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Ahluwalia, Amrita, Michael K. Jones, Xiaoming Deng, Zsusanna Sandor, Sandor Szabo, and Andrzej S. Tarnawski. "An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 4 (2013): G325—G332. http://dx.doi.org/10.1152/ajpgi.00127.2013.

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Gastric mucosa of aging individuals exhibits increased susceptibility to injury and delayed healing. Our previous studies in young rats showed that healing of mucosal injury depends on and is critically dependent on VEGF and angiogenesis. Since angiogenesis in aging gastric mucosa has not been examined before, in this study we examined the extent to which angiogenesis is impaired in gastric mucosa of aging vs. young rats and determined the underlying mechanisms with a focus on mucosal expression of VEGF (proangiogenic factor) and endostatin (antiangiogenic factor). Aging rats had significantly

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Wang, J. Y., and L. R. Johnson. "Role of transglutaminase and protein cross-linking in the repair of mucosal stress erosions." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 5 (1992): G818—G825. http://dx.doi.org/10.1152/ajpgi.1992.262.5.g818.

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We have recently demonstrated that polyamines are absolutely required for gastric and duodenal mucosal repair after stress. Polyamines act as substrates for transglutaminase and facilitate protein cross-linking. The current study tests whether transglutaminase and protein cross-linking are involved in the mechanism of mucosal healing. Rats were fasted 22 h, placed in restraint cages, and immersed in water to the xiphoid process for 6 h. Animals were killed immediately or 4, 12, or 24 h after stress. Gastric and duodenal mucosa were examined histologically and grossly, and transglutaminase acti

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Banan, A., J. Y. Wang, S. A. McCormack, and L. R. Johnson. "Relationship between polyamines, actin distribution, and gastric healing in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 5 (1996): G893—G903. http://dx.doi.org/10.1152/ajpgi.1996.271.5.g893.

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ntragastric administration of 3.4 M NaCl damages the gastric mucosa and increases the activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine synthesis. Polyamines are essential for the repair of gastric erosions. Little is known about the restitution of damaged mucosa except that cell migration is essential. Actin is the principal cytoskeletal protein and is essential for migration. This investigation determines the relationship between polyamines, actin, and gastric healing. Rats were fasted for 22 h and given 1.0 ml of 3.4 M NaCl intragastrically and killed 1, 2, 4,

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Jolaiya, Tolulope Funbi, Muinah Adenike Fowora, Charles Onyekwere, et al. "Duodenal ulcer promoting gene (DupA), plasticity region genes and sigma factors in H. pyloristrains from Nigeria." Journal of Infection in Developing Countries 14, no. 02 (2020): 162–68. http://dx.doi.org/10.3855/jidc.11746.

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Introduction: Helicobacter pylori is a principal cause of gastric cancer. The aim of this study was to determine the prevalence and contribution of duodenal ulcer promoting gene A (dupA), the plasticity region genes and sigma factors in relation to their pathological expression of H. pylori infections in the Nigerian population. Methodology: Polymerase Chain Reaction was used to analyze a total of forty-nine H. pylori strains isolated from patients attending various endoscopic units in tertiary hospitals in Nigeria for complete dupA (G27 variant), jhp0917, jhp0918, other plasticity regio

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Banan, Ali, Shirley A. McCormack, and Leonard R. Johnson. "Polyamines are required for microtubule formation during gastric mucosal healing." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 5 (1998): G879—G885. http://dx.doi.org/10.1152/ajpgi.1998.274.5.g879.

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Polyamines are essential for the repair of gastric and duodenal erosions. Concentrated NaCl (3.4 M) given intragastrically damages the oxyntic gland mucosa and increases the activity of gastric mucosal ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis. The nature of the process of restitution of damaged mucosa is not well known, except that cell migration and the actin cytoskeleton play a prominent role. Microtubules are cytoskeletal components essential for cell migration. The present investigation determines the relationship between polyamines, the distribu

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Kurose, Iwao, Soichiro Miura, Dai Fukumura, et al. "Attenuating Effect of Antithrombin III on the Fibrinolytic Activation and Microvascular Derangement in Rat Gastric Mucosa." Thrombosis and Haemostasis 71, no. 01 (1994): 119–23. http://dx.doi.org/10.1055/s-0038-1642394.

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SummaryThe roles for the fibrinolytic activation and disorder of coagulation in formation of gastric ulcer induced by microvascular derangement were investigated. The rat stomach was exposed and repeated electrical stimuli (RES) were applied on the small arterial wall close to the lesser curvature to induce mucosal microcirculatory disturbances. The level of tissue-type plasminogen activator (t-PA), a key enzyme for fibrinolytic activity, in the regional blood of the stomach was significantly elevated immediately after RES. At 5 min after RES, the leakage of FITC-labeled albumin and thrombus f

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Kim, S. H. "Gastric mucosal erosions -radiologic evaluation-." Journal of the Korean Radiological Society 21, no. 6 (1985): 985. http://dx.doi.org/10.3348/jkrs.1985.21.6.985.

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Garrick, T., C. V. Grijalva, and M. Trauner. "Lateral hypothalamic lesions cause gastric injury by stimulating gastric contractility." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 1 (1993): G138—G142. http://dx.doi.org/10.1152/ajpgi.1993.265.1.g138.

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Changes in gastric contractility following lateral hypothalamic (LH) lesions with and without bilateral cervical vagotomy were measured in urethan-anesthetized rats. LH lesions were induced with direct current passed through stereotaxically placed electrodes. Gastric contractility was recorded continuously for 4 h with acutely implanted strain gauge force transducers and analyzed by computer. LH lesions consistently stimulated gastric contractility and caused more gastric mucosal injury than control conditions. Vagotomy blocked both gastric mucosal injury and high-amplitude gastric contraction

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Tepperman, B. L., J. M. Besco, J. A. Kiernan, and B. D. Soper. "Relationship between myeloperoxidase activity and the ontogenic response of rat gastric mucosa to ethanol." Canadian Journal of Physiology and Pharmacology 69, no. 12 (1991): 1882–88. http://dx.doi.org/10.1139/y91-278.

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We have examined the gastric luminal content of Na+, K+, and protein and mucosal levels of myeloperoxidase in rats between the ages of 10 and 60 days in response to luminal instillation of ethanol (20 and 50% w/v). In control animals the appearances of ions and protein and myeloperoxidase activities were low and similar in all age groups. Luminal content of cations and protein increased in response to both 20 and 50% ethanol and were greater in animals older than 20 days when compared with younger rats. However, ethanol treatment resulted in a significant degree of mucosal cellular disruption

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Eaton, K. A., M. J. Radin, L. Kramer, et al. "Epizootic Gastritis Associated with Gastric Spiral Bacilli in Cheetahs (Acinonyx jubatus)." Veterinary Pathology 30, no. 1 (1993): 55–63. http://dx.doi.org/10.1177/030098589303000107.

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An outbreak of vomiting in a group of captive cheetahs ( Acinonyx jubatus) was investigated, and histologic examination revealed chronic gastritis characterized by infiltration of lymphocytes and numerous plasma cells and epithelial erosions. Lymphoid follicles, globule leukocytes, scattered neutrophils, and (in one animal) abscessed gastric glands were inconsistent findings. In addition, necropsy of three cheetahs revealed gastric mucosal hyperplasia. Two kinds of bacteria were identified in the stomachs of infected cheetahs. Numerous long, tightly coiled motile Gastrospirillum-like organisms

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Moroz, E. V., A. Y. Karateev, E. V. Kryukov, A. A. Sokolov, and E. N. Artemkin. "Comparison of the Endoscopic Picture in Case of Complications of the upper Gastrointestinal Tract Caused by the Use of Antithrombotic Agents and Non-Steroidal Anti-Inflammatory Drugs." Acta Biomedica Scientifica 4, no. 5 (2019): 19–25. http://dx.doi.org/10.29413/abs.2019-4.5.3.

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Intaking antithrombotic funds (ATA) and non-steroidal anti-inflammatory drugs (NSAIDs) is one of the most frequent causes of pathology in gastrointestinal (GI) tract.The purpose of the study: comparison of pathological changes of the mucous membrane in the upper GI tract, that occur against the background of ATA and NSAIDs admission.Material and methods. Endoscopic data of two groups of patients taking ATA and NSAIDS have been compared. The first group of 448 patients from the 10th Gastrointestinal Department in N.N. Burdenko Main Military Clinical Hospital was on record from 2013 to 2017. The

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Afanasenkova, T. E., E. D. Golovanova, and E. E. Dubskaya. "Chronic Helicobacter pylori induced gastritis with erosive lesions of the gastric mucosa in the elderly." Experimental and Clinical Gastroenterology 1, no. 10 (2020): 33–38. http://dx.doi.org/10.31146/1682-8658-ecg-170-10-33-38.

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Аim. To study the clinical course of chronic gastritis with erosions in the elderly, depending on the presence of Helicobacter pylori in the gastric mucosa.Materials and methods. 75 patients (50 women and 25 men) aged 60 to 82 years with chronic erosive gastritis were examined. Тhey complained of pain in the epigastric region, pain of other localization, heaviness in the epigastric region, nausea, heartburn, constipation, having comorbidities. Patients were divided into 4 groups depending on the degree of contamination of the gastric mucosa with Helicobacter pylori: 1 group consisted of 20 peo

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Chaudhary, Shatdal, Altaban Rahi, Anita Shah, Aakash Shahi, Badri Kumar Gupta, and Niraj Kumar Jaiswal. "Prevalence of Helicobacter Pylori Infection in Patients with Portal Hypertension." Journal of Universal College of Medical Sciences 6, no. 2 (2018): 16–19. http://dx.doi.org/10.3126/jucms.v6i2.22470.

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Introduction: Helicobacter pylori (H. pylori) is a microaerophile gram-negative bacillus which is found mainly on the surface of mucous membrane of the prepyloric part of the stomach. It is found to be infecting approximately 50% of world population. In patients with liver cirrhosis, the prevalence of H. pylori is variable. A high incidence of H. pylori colonization has been found in portal hypertension; especially in those with gastric erosion. This study was done to find out the prevalence of H. pylori infection in patients with portal hypertension at Universal College of Medical Sciences Te

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Hierlihy, Lynn E., John L. Wallace, and Alastair V. Ferguson. "Role of gastric acid secretion and blood flow in the development of vagal stimulation induced gastric mucosal damage." Canadian Journal of Physiology and Pharmacology 71, no. 10-11 (1993): 829–34. http://dx.doi.org/10.1139/y93-124.

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Vagal stimulation has been shown to result in the development of gastric mucosal erosions in the rat, although the mechanisms underlying the development of such erosions are not known. The effects of vagal stimulation on gastric acid secretion and mucosal blood flow were examined in urethane-anesthetized male Sprague–Dawley rats to determine whether changes in these factors correlate with the mucosal damage in response to vagal stimulation. Electrical stimulation (5 Hz, 5 V, 1 ms for 60 min) of afferent or efferent components of the vagi was not found to induce any significant increase in the

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Wada, Kouichirou, Yoshinori Kamisaki, Tsuyoshi Ohkura, et al. "Direct measurement of nitric oxide release in gastric mucosa during ischemia-reperfusion in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 3 (1998): G465—G471. http://dx.doi.org/10.1152/ajpgi.1998.274.3.g465.

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Nitric oxide (NO) generation in the rat gastric mucosa during ischemia-reperfusion was measured using an NO-sensitive electrode. Under pentobarbital sodium anesthesia, an electrode was inserted into the submucosa from the serous membrane side in the fundus. After steady-state baseline recording, the celiac artery was clamped for 30 min, and then ischemia-reperfusion was achieved by removing the clamp. The clamping of the celiac artery caused a decrease in blood flow and an increase in NO level in the gastric tissue. Just after the removal of the clamp, the NO level rapidly fell and returned to

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