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Journal articles on the topic 'Gastric secretory function'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kalmykov, S.A., G.S. Urdina, and I.V. Pelikh. "Study of the efficiency use of physical rehabilitation in patients with chronic gastritis." Pedagogics, psychology, medical-biological problems of physical training and sports 18, no. 9 (2014): 30–34. https://doi.org/10.5281/zenodo.10125.

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<em>Purpose: </em>to make physical rehabilitation program for patients with chronic gastritis type B, promotes normalization of gastric secretory function and prolong the period of remission. Objectives of the study was to assess the dynamics of gastric secretory function and functional status of the autonomic nervous system in patients with the chronic gastritis type B<em>. Material:</em> the study involved 37 women with a diagnosis of the chronic gastritis type B, increased acid gastric function. <em>Results:</em> it was established the positive influence of corrective exercises for the lowe

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2

Simpson, Kenneth W., Dalit Strauss-Ayali, Eugenio Scanziani, et al. "Helicobacter felis Infection Is Associated with Lymphoid Follicular Hyperplasia and Mild Gastritis but Normal Gastric Secretory Function in Cats." Infection and Immunity 68, no. 2 (2000): 779–90. http://dx.doi.org/10.1128/iai.68.2.779-790.2000.

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ABSTRACT The relationship of Helicobacter felis, a bacterium observed in the stomachs of cats, to gastric disease is unclear. The objective of this study was to determine if H. felisinfection alters gastric histopathology, proinflammatory cytokine expression, and secretory function and evokes a humoral immune response in cats. Five specific-pathogen-free (SPF)Helicobacter-free cats were studied before and for 1 year after oral inoculation with H. felis (ATCC 49179). Four SPFH. felis-uninfected cats served as controls. The stomachs of all five H. felis-inoculated cats became colonized, as deter

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3

Hyman, Paul E., David D. Clarke, Susan L. Everett, et al. "Gastric acid secretory function in preterm infants." Journal of Pediatrics 106, no. 3 (1985): 467–71. http://dx.doi.org/10.1016/s0022-3476(85)80682-x.

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4

McCOLL, K. E. L., and E. EL-OMAR. "Gastrin releasing peptide and its value in assessing gastric secretory function." Alimentary Pharmacology & Therapeutics 9, no. 4 (2007): 341–47. http://dx.doi.org/10.1111/j.1365-2036.1995.tb00392.x.

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5

Friis-Hansen, Lennart, Frank Sundler, Ying Li, et al. "Impaired gastric acid secretion in gastrin-deficient mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 3 (1998): G561—G568. http://dx.doi.org/10.1152/ajpgi.1998.274.3.g561.

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To further understand the role of the peptide hormone gastrin in the development and function of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic stem cells. Mutant mice were viable and fertile, without obvious visible abnormalities. However, gastric function was severely affected by the loss of gastrin. Basal gastric acid secretion was abolished and could not be induced by histamine, carbachol, or gastrin. Histological analysis revealed alterations in the two cell types primarily involved in acid secretion, parietal and enterochromaffin-like (ECL) cells. Pa

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6

Kelly, Eric J., Keith G. Brownlee, and Simon J. Newell. "Gastric secretory function in the developing human stomach." Early Human Development 31, no. 2 (1992): 163–66. http://dx.doi.org/10.1016/0378-3782(92)90043-g.

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7

Kalantar, I. L., L. V. Nozdracheva, and K. P. Gutiontova. "A method of recording gastric secretory function in mice." Bulletin of Experimental Biology and Medicine 103, no. 4 (1987): 572–73. http://dx.doi.org/10.1007/bf00842503.

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8

Simpson, Kenneth W., Dalit Strauss-Ayali, Reinhard K. Straubinger, et al. "Gastric secretory function in cats with Helicobacter pylori associated gastritis." Gastroenterology 118, no. 4 (2000): A1308. http://dx.doi.org/10.1016/s0016-5085(00)81091-4.

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9

Shlygin, G. K., L. S. Vasilevskaya, and L. G. Ignatenko. "Effect of glutamic acid and glutathione on gastric secretory function." Bulletin of Experimental Biology and Medicine 106, no. 4 (1988): 1386–89. http://dx.doi.org/10.1007/bf00837741.

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10

Zhuraeva, M. A., V. A. Aleynik, N. D. Ashuralieva, and D. S. Kholikova. "Effect of pentagastrin and gastrin-17 on the secretory function of the gastric glands." Experimental and Clinical Gastroenterology, no. 11 (January 2, 2022): 75–78. http://dx.doi.org/10.31146/1682-8658-ecg-195-11-75-78.

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The regulation of the digestive glands of the stomach and pancreas in the body of animals and humans is provided by peptides, most of which are in various molecular forms. 10 molecular forms of peptides of the gastrin group and 5 peptides of the cholecystokinin (CCK) group have been identiﬁed, containing in their structure from 4 to 56 amino acids, the physiological role of which has been little studied. It has been proven that the liver removes up to 85% of short-chain peptides of the gastrin (pentagastrin) and cholecystokinin (CCK-8) groups.

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11

Walsh, JohnH. "Role of gastric bombesin-like peptides and related gene products in gastric secretory function." Regulatory Peptides 19, no. 1-2 (1987): 143. http://dx.doi.org/10.1016/0167-0115(87)90163-7.

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12

Hinkle, Karen L., Gina C. Bane, Ali Jazayeri, and Linda C. Samuelson. "Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 284, no. 1 (2003): G145—G153. http://dx.doi.org/10.1152/ajpgi.00283.2002.

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Gastrin-deficient mice have impaired basal and agonist-stimulated gastric acid secretion. To analyze whether an intrinsic parietal cell defect contributed to the reduced acid secretion, we analyzed parietal cell calcium responses and acid secretory function in vitro. Parietal cells were purified by light-scatter cell sorting and calcium responses to gastrin, histamine, and carbachol were measured in gastrin-deficient and wild-type mice cell preparations. Surprisingly, basal and histamine-induced calcium concentrations were higher in the mutant cell preparations. [14C]aminopyrine uptake analysi

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13

Kuznetsov, A., L. Smelysheva, O. Arkhipova, A. Moskovkin та N. Sazhina. "STOMACH SECRETORY FUNCTION UNDER MUSCLE LOAD IN THE CONDITIONS OF PHARMACOLOGICAL BLOCADE OF M-CHOLINORECEPTORS AND β-ADRENOCEPTORS". Human Sport Medicine 19, S1 (2019): 50–60. http://dx.doi.org/10.14529/hsm19s107.

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Aim. The article deals with establishing the effect of muscle load on the stomach secretory function in the conditions of partial pharmacological blockade of M-cholinoreceptors and β-adrenoceptors in patients with duodenal acidification. Materials and methods. 22 males aged 18–23 years participated in the study. The stomach secretory function at rest under a 30-minute cycle ergometer load of 36 900 kgm combined with a partial pharmacological blockade of M-cholinoreceptors (1.5 mg per kg of body mass) and β-adrenoceptors (0.6 mg obsidan per kg of body mass) was studied using gastric and gastrod

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Butov, M. A., M. Msakni, and V. M. Butova. "The effect of rabeprazole on the secretory and motor function of the gastrointestinal tract." Experimental and Clinical Gastroenterology, no. 11 (March 26, 2024): 67–74. http://dx.doi.org/10.31146/1682-8658-ecg-219-11-67-74.

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Parietal cell proton pump inhibitors (PPIs) have become firmly established in clinician practice. When discussing the features of their action, as a rule, researchers focus on their antisecretory effect. In the available literature, we found only a single report on the effect of PPIs on the motor-evacuation function of the gastrointestinal tract (GIT). We have found that the PPI rabeprazole not only has an antisecretory effect, but also normalizes the motor-evacuation function of all parts of the gastrointestinal tract. In this regard, it can be used in patients with gastric hypersecretion in

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15

Shirapova, M. S. "Gastric secretory function in patients with hemorrhagic fever with renal syndrome." Kazan medical journal 70, no. 3 (1989): 216–17. http://dx.doi.org/10.17816/kazmj99895.

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The aim of this work was to study secretory (acid-forming and proteolytic) functions of the stomach in patients and recovering patients with hemorrhagic fever with renal syndrome (HFRS).Seventy-six relapsed HFRS patients under 50 years of age without concomitant or past gastrointestinal diseases were examined. Dynamic follow-up was performed in the same patients. Diagnosis in all patients was confirmed serologically (4-fold increase of antibody titers by MFA method in dynamic examination of sera). The control group consisted of 26 healthy individuals.

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F. Parente, R. Negrini, V. Imbesi,. "Presence of Gastric Autoantibodies Impairs Gastric Secretory Function in Patients withHelicobacter pylori-positive Duodenal Ulcer." Scandinavian Journal of Gastroenterology 36, no. 5 (2001): 474–78. http://dx.doi.org/10.1080/00365520120700.

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17

Tuo, Biguang, Zhenyu Ju, Brigitte Riederer, et al. "Telomere shortening is associated with reduced duodenal HCO3−secretory but normal gastric acid secretory capacity in aging mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 12 (2012): G1312—G1321. http://dx.doi.org/10.1152/ajpgi.00035.2012.

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The incidence of duodenal ulcer, especially Helicobacter pylori-negative duodenal ulcer, strongly increases with age. In humans, telomere length shortening is considered to be one critical factor in cellular senescence and organ survival. In this study, we compared basal and stimulated gastric acid and duodenal HCO3−secretory rates in aged late-generation (G3) telomerase-deficient (mTERC−/−) mice, which are characterized by severe telomere dysfunction due to the inability to elongate telomeres during cell division. We found that basal and forskolin-stimulated HCO3−secretion and short-circuit c

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18

Calamita, Giuseppe, and Christine Delporte. "Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease." Cells 12, no. 17 (2023): 2170. http://dx.doi.org/10.3390/cells12172170.

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Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of vari

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19

Lambrecht, Nils W. G., Iskandar Yakubov, David Scott, and George Sachs. "Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion." Physiological Genomics 21, no. 1 (2005): 81–91. http://dx.doi.org/10.1152/physiolgenomics.00212.2004.

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Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by c

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20

Mosinski, J. David, Ali Aminian, Christopher L. Axelrod, et al. "Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats." American Journal of Physiology-Endocrinology and Metabolism 320, no. 2 (2021): E392—E398. http://dx.doi.org/10.1152/ajpendo.00467.2020.

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The onset and progression of type 2 diabetes (T2D) results from failure to secrete sufficient amounts of insulin to overcome peripheral insulin resistance. Here, we demonstrate that Roux-en-Y gastric bypass (RYGB) restores islet function and morphology compared to sham and pair-fed controls in ZDF rats. The improvements in islet function were largely attributable to enhanced insulin content and secretory function in response to glucose stimulation.

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21

Parente, F., R. Negrini, V. Imbesi, et al. "Presence of Gastric Autoantibodies Impairs Gastric Secretory Function in Patients with Helicobacter pylori-positive Duodenal Ulcer." Scandinavian Journal of Gastroenterology 36, no. 5 (2001): 474–78. http://dx.doi.org/10.1080/003655201750153232.

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22

Isenberg, Sherwin J., Candy Abrams, and Paul E. Hyman. "Effects of Cyclopentolate Eyedrops on Gastric Secretory Function in Pre-term Infants." Ophthalmology 92, no. 5 (1985): 698–700. http://dx.doi.org/10.1016/s0161-6420(85)33979-9.

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23

Cho, C. H., and C. W. Ogle. "The inhibitory action of 5-hydroxytryptamine on gastric secretory function in rats." British Journal of Pharmacology 87, no. 2 (1986): 371–77. http://dx.doi.org/10.1111/j.1476-5381.1986.tb10826.x.

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24

Buryak, Vladimir N., Tatyana I. Antonova, Inna V. Malysheva, et al. "The role of secretary-motor stomach disorders in the genesis of atopic dermatitis in children." Pediatrician (St. Petersburg) 11, no. 1 (2020): 13–18. http://dx.doi.org/10.17816/ped11113-18.

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Objective: to study the relationship of the main mediators of atopy and clinical and morphological characteristics lesions of the stomach with its secretory-motor disorders in children with atopic dermatitis. We study 134 patients aged 7 to 14 years with atopic dermatitis and 30 healthy children as control group. All children passed general clinical and laboratory instrumental investigations. In addition, children with manifestations of atopic dermatitis and secretory-motor disorders of the stomach Fibroesophagogastroduodenoscopy, topographic intragastric pH-metry with aspiration biopsy of the

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25

Malinowska, Danuta H., Ann M. Sherry, Kirti P. Tewari, and John Cuppoletti. "Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels." American Journal of Physiology-Cell Physiology 286, no. 3 (2004): C495—C506. http://dx.doi.org/10.1152/ajpcell.00386.2003.

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Our objective was to identify and localize a K+ channel involved in gastric HCl secretion at the parietal cell secretory membrane and to characterize and compare the functional properties of native and recombinant gastric K+ channels. RT-PCR showed that mRNA for Kir2.1 was abundant in rabbit gastric mucosa with lesser amounts of Kir4.1 and Kir7.1, relative to β-actin. Kir2.1 mRNA was localized to parietal cells of rabbit gastric glands by in situ RT-PCR. Resting and stimulated gastric vesicles contained Kir2.1 by Western blot analysis at ∼50 kDa as observed with in vitro translation. Immunocon

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26

Vara-Luiz, Francisco, Ivo Mendes, Carolina Palma, et al. "Age-Related Decline of Gastric Secretion: Facts and Controversies." Biomedicines 13, no. 7 (2025): 1546. https://doi.org/10.3390/biomedicines13071546.

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Aging is associated with structural and functional changes in the gastrointestinal tract; however, its impact on gastric secretion remains unclear. This scoping review examines whether gastric secretion declines with age and explores its clinical implications. Following the PRISMA guidelines, PubMed, Web of Science, Embase, and Google Scholar were systematically searched from inception to December 2024. Fifteen studies (both animal and human) met the inclusion criteria: they were written in English, directly relevant to aging and gastric secretion, and had a clearly stated methodology. Evidenc

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Miller, Marian L., Anastasia Andringa, Yana Zavros, Emily M. Bradford, and Gary E. Shull. "Volume Density, Distribution, and Ultrastructure of Secretory and Basolateral Membranes and Mitochondria Predict Parietal Cell Secretory (Dys)function." Journal of Biomedicine and Biotechnology 2010 (2010): 1–13. http://dx.doi.org/10.1155/2010/394198.

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Acid secretion in gastric parietal cells requires highly coordinated membrane transport and vesicle trafficking. Histologically, consensus defines acid secretion as the ratio of the volume density (Vd) of canalicular and apical membranes (CAMs) to tubulovesicular (TV) membranes, a value which varies widely under normal conditions. Examination of numerous achlorhydric mice made it clear that this paradigm is discrepant when used to assess most mice with genetic mutations affecting acid secretion. Vd of organelles in parietal cells of 6 genetically engineered mouse strains was obtained to identi

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Hervatin, F., E. Moreau, R. Ducroc, B. Garzon, and J. P. Geloso. "Development of Acid Secretory Function in the Rat Stomach." Journal of Pediatric Gastroenterology and Nutrition 9, no. 1 (1989): 82–88. http://dx.doi.org/10.1002/j.1536-4801.1989.tb09825.x.

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Summary:Gastric acid secretion was studied in anesthetized rats from day 6 of the postnatal period up to the time of weaning. Basal H+ secretion was detected from day 6 in the first group studied (2.4 ± 0.2 μEq of H+/10 min/100 g of bodyweight, BW) and remained constant up to the time of weaning (day 18: 2.5 ± 0.2 μEq of H+/10 min/100 g of body weight) except for the period between days 10 and 12, when it fell significantly (1.5 ± 0.06 μEq H+/10 min/100 g of BW on day 12). Both histamine H2 receptor sensitivity and intracellular transduction mechanism activities were evaluated by studying the

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Ammar, David A., Phuong N. B. Nguyen, and John G. Forte. "Functionally distinct pools of actin in secretory cells." American Journal of Physiology-Cell Physiology 281, no. 2 (2001): C407—C417. http://dx.doi.org/10.1152/ajpcell.2001.281.2.c407.

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Acid secretion by the gastric parietal cell is controlled through movement of vesicles containing the proton pump, the H+-K+-ATPase (HK). We have used latrunculin B (Lat B), which binds to monomeric actin, to investigate actin turnover in the stimulated parietal cell. In isolated gastric glands, relatively high concentrations of Lat B were required to inhibit acid accumulation (ED50∼70 μM). Cultured parietal cells stimulated in the presence of low Lat B (0.1–1 μM) have reduced lamellipodia formation and some aberrant punctate phalloidin-stained structures, but translocation of HK and vacuolar

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Hong, Qu, Lawrence F. Brown, Harold F. Dvorak, and Ann M. Dvorak. "Ultrastructural Immunogold Localization of Osteopontin in Human Gastric Mucosa." Journal of Histochemistry & Cytochemistry 45, no. 1 (1997): 21–33. http://dx.doi.org/10.1177/002215549704500104.

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We performed ultrastructural immunogold localization of osteopontin in the mucosa of human stomach. This adhesive glycoprotein was present in mucous and chief cells of the epithelial layer and in macrophages in the lamina propria. Parietal and endocrine cells of the epithelial layer and mast cells and plasma cells in the lamina propria did not contain osteopontin, serving as internal negative controls. Subcellular localizations of osteopontin included secretory granules and synthetic organelles in mucous and chief cells and phagolysosomes in macrophages. Extracellular concentrations of osteopo

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31

Jo, Hyemin, Cheol Min Shin, Soyeon Ahn, et al. "Insulin resistance and impaired insulin secretion and gastrointestinal cancer risk in Korean adults: Preliminary results from Korean Genome and Epidemiology study." Journal of Clinical Oncology 42, no. 3_suppl (2024): 761. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.761.

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761 Background: To date, few studies conducted on the effect of insulin resistance or insulin secretory function on cancer risk in non-diabetic population. This study evaluated whether insulin resistance and/or insulin secretory function affect gastrointestinal cancer risk in the Korean population. Methods: We analyzed data from Korean Genome and Epidemiology Study, Korea Association Resource dataset. It consists of 10,030 participants aged 40-69y observed from 2001 to 2018. The risk of all cancers, and gastrointestinal cancers were assessed. Homeostasis Model Assessment of Insulin Resistance

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Fujii, Takuto, Kyosuke Fujita, Noriaki Takeguchi, and Hideki Sakai. "Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells." Biological & Pharmaceutical Bulletin 34, no. 6 (2011): 810–12. http://dx.doi.org/10.1248/bpb.34.810.

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Hrinchenko, OA, and PI Ianchuk. "The role of nitric oxide and taurine in regulation of dogs gastric secretory function." Fiziolohichnyĭ zhurnal 58, no. 6 (2012): 48–56. http://dx.doi.org/10.15407/fz58.06.048.

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Dammann, Burkhardt, and Wolf. "The effects of oral rabeprazole on endocrine and gastric secretory function in healthy volunteers." Alimentary Pharmacology & Therapeutics 13, no. 9 (1999): 1195–203. http://dx.doi.org/10.1046/j.1365-2036.1999.00545.x.

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35

Yao, X., A. Thibodeau, and J. G. Forte. "Ezrin-calpain I interactions in gastric parietal cells." American Journal of Physiology-Cell Physiology 265, no. 1 (1993): C36—C46. http://dx.doi.org/10.1152/ajpcell.1993.265.1.c36.

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Gastric ezrin, a membrane-cytoskeletal linker with sequence homology to talin and erythrocyte band 4.1, has been associated with the remodeling of parietal cell apical membrane that occurs with adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase stimulation. Here we examine the interrelationship between parietal cell ezrin and Ca(2+)-dependent protease activity. Addition of Ca2+ to sonicated gastric gland preparations rendered a relatively selective proteolysis of the 80-kDa ezrin, accompanied by the appearance of a 55-kDa breakdown product. Ca(2+)-dependent proteolysis of ezr

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Sokolova, Olga, and Michael Naumann. "Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer." Cellular and Molecular Life Sciences 78, no. 10 (2021): 4765–83. http://dx.doi.org/10.1007/s00018-021-03816-8.

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AbstractInfection with H. pylori induces a strong host cellular response represented by induction of a set of molecular signaling pathways, expression of proinflammatory cytokines and changes in proliferation. Chronic infection and inflammation accompanied by secretory dysfunction can result in the development of gastric metaplasia and gastric cancer. Currently, it has been determined that the regulation of many cellular processes involves ubiquitinylation of molecular effectors. The binding of ubiquitin allows the substrate to undergo a change in function, to interact within multimolecular si

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Pavlovich, I. M., G. A. Alper, and A. V. Gordienko. "The diagnostic value of indicators of acid-forming and pepsinoguena functions of the stomach in the detection of precancerous changes of the gastric mucosa in patients with chronic gastritis." Bulletin of the Russian Military Medical Academy 20, no. 4 (2018): 72–75. http://dx.doi.org/10.17816/brmma12273.

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It was found that in patients with chronic atrophic gastritis, low gastric secretory functions are present in the localization of atrophy in the mucous membrane of the body of the stomach with a tendency to decrease in indices as the degree of atrophy increases and are not associated with the presence of disregenerative changes in the gastric mucosa (intestinal metaplasia and dysplasia). Reduced levels of pepsin in gastric juice and reduced levels of pepsinogen in the mucous membrane of the body of the stomach reliably reflect the presence of severe atrophy of the mucous membrane of the body o

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Kagota, Shuji, Kohei Taniguchi, Sang-Woong Lee, et al. "Analysis of Extracellular Vesicles in Gastric Juice from Gastric Cancer Patients." International Journal of Molecular Sciences 20, no. 4 (2019): 953. http://dx.doi.org/10.3390/ijms20040953.

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Extracellular vesicles (EVs) are secretory membrane vesicles containing lipids, proteins, and nucleic acids; they function in intercellular transport by delivering their components to recipient cells. EVs are observed in various body fluids, i.e., blood, saliva, urine, amniotic fluid, and ascites. EVs secreted from cancer cells play important roles in the formation of their environment, including fibrosis, angiogenesis, evasion of immune surveillance, and even metastasis. However, EVs in gastric juice (GJ-EVs) have been largely unexplored. In this study, we sought to clarify the existence of G

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Mussa, Bashair M., Sanjay Sood, and Anthony JM Verberne. "Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis." World Journal of Gastroenterology 24, no. 34 (2018): 3821–33. http://dx.doi.org/10.3748/wjg.v24.i34.3821.

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Grinchenko, Olga A., and Petro I. Yanchuk. "The Role of Nitric Oxide and Taurine in Regulation of Gastric Secretory Function in Dogs." International Journal of Physiology and Pathophysiology 4, no. 3 (2013): 189–200. http://dx.doi.org/10.1615/intjphyspathophys.v4.i3.20.

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41

Stürmer, Reising, and Hoffmann. "The TFF Peptides xP1 and xP4 Appear in Distinctive Forms in the Xenopus laevis Gastric Mucosa: Indications for Different Protective Functions." International Journal of Molecular Sciences 20, no. 23 (2019): 6052. http://dx.doi.org/10.3390/ijms20236052.

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The gastric secretory trefoil factor family (TFF) peptides xP1 and xP4 are the Xenopus laevis orthologs of mammalian TFF1 and TFF2, respectively. The aim of this study was to analyze the molecular forms of xP1 and xP4 in the X. laevis gastric mucosa by FPLC. xP1 mainly occurred in a monomeric low-molecular-mass form and only a minor subset is associated with the mucus fraction. The occurrence of monomeric xP1 is unexpected because of its odd number of cysteine residues. Probably a conserved acidic residue flanking Cys55 allows monomeric secretion. Furthermore, Cys55 is probably post-translatio

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Minaieva, A. O., O. I. Zalubovska, T. I. Тiupka, M. I. Lytvynenko, and Yu N. Аvidzba. "PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL GASTRIC ULCER BY A NEW HERBAL AGENT." Likarska sprava, no. 1-2 (May 25, 2021): 45–50. http://dx.doi.org/10.31640/jvd.1-2.2021(7).

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The aim of the study was to study the effect of liposome emulsion with grape seed polyphenols (LEGSP) on the secretory and motor-evacuatory functions of the gastrointestinal tract and efficacy in experimental gastric ulcer. Materials and methods. The experiments were carried out on 36 white non-linear male rats weighing 180–220 g and 12 white non-linear mice weighing 18–20 g of different sexes. The effect of LEGSP on the secretion of gastric juice was assessed in terms of total, free and associated acidity of gastric contents; on the motor-evacuation function of the gastrointestinal tract – ac

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Capoccia, Benjamin J., Jochen K. M. Lennerz, Andrew J. Bredemeyer, Jeffery M. Klco, John L. Frater, and Jason C. Mills. "Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells." Physiological Genomics 43, no. 3 (2011): 174–86. http://dx.doi.org/10.1152/physiolgenomics.00084.2010.

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Despite their divergent developmental ancestry, plasma cells and gastric zymogenic (chief) cells share a common function: high-capacity secretion of protein. Here we show that both cell lineages share increased expression of a cassette of 269 genes, most of which regulate endoplasmic reticulum (ER) and Golgi function, and they both induce expression of the transcription factors X-box binding protein 1 ( Xbp1) and Mist1 during terminal differentiation. XBP1 is known to augment plasma cell function by establishing rough ER, and MIST1 regulates secretory vesicle trafficking in zymogenic cells. We

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Xu, Jie, Penghong Song, Marian L. Miller, et al. "Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach." Proceedings of the National Academy of Sciences 105, no. 46 (2008): 17955–60. http://dx.doi.org/10.1073/pnas.0800616105.

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Slc26a9 is a recently identified anion transporter that is abundantly expressed in gastric epithelial cells. To study its role in stomach physiology, gene targeting was used to prepare mice lacking Slc26a9. Homozygous mutant (Slc26a9−/−) mice appeared healthy and displayed normal growth. Slc26a9 deletion resulted in the loss of gastric acid secretion and a moderate reduction in the number of parietal cells in mutant mice at 5 weeks of age. Immunofluorescence labeling detected the H-K-ATPase exclusively on the apical pole of gastric parietal cells in Slc26a9−/− mice, in contrast to the predomin

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Kurnikova, Irina Alekseevna, Tatiana Evgen'evna Chernyshova, Irina Vladimirovna Gur'eva, and Guzyal' Ilgisovna Kliment'eva. "Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy." Diabetes mellitus 14, no. 2 (2011): 94–97. http://dx.doi.org/10.14341/2072-0351-5644.

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Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending on DM duration (gr. 1 lessthan 10 yr, gr. 2 over 10 yr). Vegetative equilibrium was estimated from the Kerdo index, rehabilitative potential from its basic constituent (morphophysiologicalindex). The motor-evacuational function of the stomach was studied with the use of a scintillation gamma-chamber, t

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Ke, Bin, Zheng-Kai Liang, Bin Li, et al. "EDIL3 is a potential prognostic biomarker that correlates with immune infiltrates in gastric cancer." PeerJ 11 (August 9, 2023): e15559. http://dx.doi.org/10.7717/peerj.15559.

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Background EDIL3, which contains epidermal growth factor-like repeats and discoidin I-like domains, is a secretory protein that plays an important role in embryonic development and various illnesses. However, the biological function of EDIL3 in gastric cancer (GC) is still unclear. The objective of this research was to explore the role and potential mechanism of EDIL3 in GC. Methods In this study, we used the GEPIA, HPA, MethSurv, SMART, STRING, GeneMANIA, LinkedOmics TIMER, TIMER2.0, TISIDB, and RNAactDrug databases to comprehensively analyze the roles of EDIL3 in GC. To validate the in silic

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Karvar, Serhan, Xuebiao Yao, James M. Crothers, Yuechueng Liu, and John G. Forte. "Localization and Function of SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein-25 and Vesicle-associated Membrane Protein-2 in Functioning Gastric Parietal Cells." Journal of Biological Chemistry 277, no. 51 (2002): 50030–35. http://dx.doi.org/10.1074/jbc.m207694200.

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The solubleN-ethylmaleimide-sensitive factor attachment protein of 25 kDa (SNAP-25) plays an important role in vesicle trafficking. Together with vesicle-associated membrane protein-2 (VAMP-2) and syntaxin, SNAP-25 forms a ternary complex implicated in docking and fusion of secretory vesicles with the plasma membrane during exocytosis. These so-called SNARE proteins are believed to regulate tubulovesicle trafficking and fusion during the secretory cycle of the gastric parietal cell. Here we examined the cellular localization and functional importance of SNAP-25 in parietal cell cultures. Adeno

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G. FALLER, M. WINTER, H. STEININGER. "Antigastric Autoantibodies and Gastric Secretory Function inHelicobacter pylori-Infected Patients with Duodenal Ulcer and Non-Ulcer Dyspepsia." Scandinavian Journal of Gastroenterology 33, no. 3 (1998): 276–82. http://dx.doi.org/10.1080/00365529850170865.

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Seregni, Ettore, Carlo Botti, Simonetta Massaron, et al. "Structure, Function and Gene Expression of Epithelial Mucins." Tumori Journal 83, no. 3 (1997): 625–32. http://dx.doi.org/10.1177/030089169708300301.

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In this review the main characteristics, i.e., structure, function and gene expression, of the different mucins are discussed. Mucin-type molecules consist of a core protein moiety (apomucin) where a number of carbohydrate chains are attached to serines and threonines by glycosidic bonds. O-linked carbohydrates form up to 80% of the molecule and the length of the glucidic side chains varies from one to more than 20 residues. At least eight mucin-like genes have been isolated so far, and the main characteristic is the presence of a central domain composed of a variable number of “tandem repeats

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Yanaka, A., S. Ito, K. J. Carter, P. J. Goddard, and W. Silen. "Effects of hypoxia on function and morphology of in vitro frog gastric mucosa." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 3 (1992): G405—G419. http://dx.doi.org/10.1152/ajpgi.1992.262.3.g405.

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The effects of gaseous hypoxia and reoxygenation on oxynticopeptic (OPC) and surface mucous cells (SMC) were examined in in vitro bullfrog gastric fundic mucosae mounted in Ussing chambers. Forskolin-stimulated H+ secretion, transmucosal potential difference (PD), and electrical resistance (R) were monitored in tissues incubated in HCO3(-)-free or HCO3(-)-containing buffer. At serosal pH (pHs) 7.2, 1 h of hypoxia with 100% N2 resulted in a decrease in PD, increase in R, and complete inhibition of H+ secretion. After 30 min of hypoxia, the morphology of OPC changed from the secretory to the non

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