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Journal articles on the topic 'Gastro-retentive dosage form'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Jain, Hemant Kumar, and Madhuri Taware. "FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO-RETENTIVE DOSAGE FORM OF ATAZANAVIR SULPHATE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 1 (2018): 60. http://dx.doi.org/10.22159/ijpps.2018v10i1.21179.

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Objective: To improve dissolution properties of atazanavir sulphate by preparing gastro-retentive granules by solid dispersion method and development of RP-HPLC method for estimation of this drug.Methods: Estimation of atazanavir sulphate was done using high performance liquid chromatography (HPLC) on inertsil column (5 µm, 250x4, 6 mm) with a mobile phase consists of methanol: water (91:9 v/v), at 0.5 ml/min flow rate and 249 nm UV detection. The method was validated as per ICH guidelines. Selection of the carrier for gastro-retentive formulation was based on phase solubility study of the dru

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2

Ramarao, Ch Taraka, J. Vijaya Ratna, and R. B. Srinivasa. "DESIGN AND CHARACTERIZATION OF ALFUZOSIN HCL GASTRORETENTIVE FLOATING MATRIX TABLETS EMPLOYING HPMC K 100M." INDIAN DRUGS 55, no. 11 (2018): 71–73. http://dx.doi.org/10.53879/id.55.11.10741.

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The present investigation involves developing gastro retentive drug delivery systems (GFDDS) of alfuzosin HCl using HPMCK100M a is the matrixing agent and floating enhancer. Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and thereby increase the oral bioavailability. From the drug release study, it was concluded that the AFTB4 formula of HPMC K 100 M matrix tablets gives the controlled release up to 12 hours by showing increased release with floating lag time 24

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Panda, Satyajit, K. Priyanka, R. Varaprasad, and Snigdha Pattnaik. "Gastroretentive Microspheres: An Innovative Approach for Prolonging Gastric Residence." International Journal of Drug Delivery Technology 9, no. 01 (2019): 01–09. http://dx.doi.org/10.25258/ijddt.9.1.1.

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Gastro-retentive drug delivery systems (GRDDS) like gastro-retentive microspheres have gained immense popularity in the field of oral drug delivery. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, swelling systems, mucoadhesion techniques, floating systems with or without effervescence are being applied to fabricate gastroret

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4

chilukala, Swathi. "Gastro retentive Drug Delivery of Cyclobenzaprine Hydrochloride." Gastroenterology Pancreatology and Hepatobilary Disorders 2, no. 1 (2018): 01–03. http://dx.doi.org/10.31579/2641-5194/006.

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Drugs that are easily absorbed from the GI tract and have a short half-life are eliminated quickly from the blood circulation, require frequent dosing. To avoid this problem, the oral controlled release formulations are being developed. Gastro-retentive dosage forms have the potential from use as controlled release systems. The purpose of this research is to develop the gastro retentive drug delivery system of centrally acting alpha adrenergic agonist cyclobenzaprine Hydrochloride (cyclobenzaprine HCl). It is well absorbed from the upper part of the GIT, due to short gastric residence time the

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5

Chauhan, Sadanand. "A Review on Gastro-Retentive Drug Delivery System." International Scientific Journal of Engineering and Management 03, no. 03 (2024): 1–9. http://dx.doi.org/10.55041/isjem01416.

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The aim of this review is to focus on the various gastro retentive approaches by investigate, compile, and present in most concise way, where the gastroprotective has gained immense popularity in the field of oral drug delivery. In the field of oral drug delivery gastro-retentive drug delivery play an important role. There are various types of GRDDS approaches which can be utilized to retain the dosage form in the stomach and release the drug slowly for an extended period of time. The various GRDDS approaches include high density, low density, mucoadhesive, expandable, magnetic systems and sup

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Pravin, Bhimrao Navgire Nilesh Paraji Musmade Amol rajendra Dhayarkar V. M. satpute Ghodake S. R. Gajanan Sanap. "Gastro Retentive Drug Delivery Systems: A Review." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 886–96. https://doi.org/10.5281/zenodo.11210033.

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In the current days, gastro retentive drug delivery systems (GRDDS) receive the great attention because they increase the performance of controlled release dosage forms, which can take orally. It is a widely employed technique to retain the dosage form in the stomach for a long period by releasing the drug slowly. These systems improved the patient compliance, which increases the therapeutic index of drugs. Various physiological barriers associated with the gastro retentive drug delivery systems such as short gastric retentive time, variation in gastric emptying time that can reduced by this t

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Rajesh, Asija, Tyagi Amarkant, Kumar Goyal Anil, and Yadav Seema. "Evaluation and Future Perspectives of Gastro Retentive Dosage Forms." International Journal of Current Pharmaceutical Review and Research 15, no. 06 (2023): 07–14. https://doi.org/10.5281/zenodo.12581582.

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AbstractIn past years, technological advances have been achieved to improve the therapeutic efficacyand medication bioavailability of oral dosage forms. In this situation, a variety of gastroretentive drug delivery systems (GRDDS) have been employed to increase the therapeuticeffectiveness of medications with a limited window of absorption, instability at alkaline pH,solubility in acidic circumstances, and local stomach activity. The physiological status of thestomach and numerous factors that have an impact on GRDDS are covered in this review.Expandable, ultra porous hydrogel, bio/mucoadhesiv

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Divya, Jain*1 Dr. Ranajit Shinde2 Shital Patil3 Krunal Mali4 Hemant Mali5. "Revolutionizing Drug Delivery: 3D Printing of Gastro-Retentive Tablets for Enhanced Therapeutic Efficacy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1933–49. https://doi.org/10.5281/zenodo.15388189.

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The ability of some heart, gastrointestinal, and infection medications to be absorbed in the body has been shown to improve significantly when using gastro-retentive dosage forms (GRDF). Because of their limited absorption windows, pharmaceutical experts usually find it difficult to develop the bioavailability of these medications at a clinically effective dosage strength. Nevertheless, these medications have a brief biological half-life, and formulations with quick release don't deliver drug levels within the therapeutic range. In addition, the need for multiple doses of the existing formulat

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9

Sanjib, Bahadur, Manisha Sahu, Baghel Pragya, Yadu Kamesh, and Naurange Tripti. "An overview on various types of gastroretentive drug delivery system." ScienceRise: Pharmaceutical Science, no. 6(28) (December 30, 2020): 4–13. https://doi.org/10.15587/2519-4852.2020.211931.

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Gastro retentive drug delivery system is one of the approaches to achieve controlled drug delivery. The gastro retentive drug delivery system is a way to prolong residence time of active pharmaceutical ingredient in gastrointestinal tract. It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Controlled drug delivery creates a window of absorption that release drug for a longer duration of time before reaching absorption site. Gastro retentive drug delivery systems have gained wide variation of oral drug distribution in the area of late

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10

Waghmare, Suchita Gulabrao, Pramod B. Khedekar, and Jayshree R. Aate. "HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough." ECS Transactions 107, no. 1 (2022): 12229–40. http://dx.doi.org/10.1149/10701.12229ecst.

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Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying t

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Maniyar, M. M., P. B. Patil, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A Review." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 771–72. http://dx.doi.org/10.22270/jddt.v9i4-a.3561.

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Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours.these systems are useful for many of the problem occurred during development of pharmaceutical dosage form. The objective of the review is to understand the current approaches of this drug delivery system.

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12

Devi, Rita, Vicky Soni, Savej Malik, et al. "Emphasizing the pharmaceutical consideration behind the development of gastro-retentive dosage form." Research Journal of Pharmacy and Technology 10, no. 4 (2017): 1209. http://dx.doi.org/10.5958/0974-360x.2017.00217.7.

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13

Shah, SamipS, ShridharJ Pandya, and MaheshK Waghulade. "Development and investigation of gastro retentive dosage form of weakly basic drug." Asian Journal of Pharmaceutics 4, no. 1 (2010): 11. http://dx.doi.org/10.4103/0973-8398.63976.

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14

KAKUMANU, Vasu Kumar, Vinod Kumar ARORA, and Arvind Kumar BANSAL. "Gastro-retentive Dosage Form for Improving Bioavailability of Cefpodoxime Proxetil in Rats." YAKUGAKU ZASSHI 128, no. 3 (2008): 439–45. http://dx.doi.org/10.1248/yakushi.128.439.

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15

Venkateswara Rao, Korlapati, and V. V. Venkatachalam. "Recent Advances in Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 3 (2016): 3221–54. http://dx.doi.org/10.37285/ijpsn.2016.9.3.1.

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Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, muco-adhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive drug delivery systems. Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by a narrow absorption window. Gastroretention would also facilitate loca

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16

Fateh, Mohd Vaseem, Vikas Kumar, Renu Chaudhary, and Vivak Ujjwal. "Gastro-retentive drug delivery system for treatment of Ulcer." International Journal of Agricultural Invention 3, no. 02 (2019): 203–10. http://dx.doi.org/10.46492/ijai/2018.3.2.18.

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Due to the comfort of administration, economical and extensibility in formulation, the most adopted route to the systemic circulation is the oral route regardless of the astounding elevation in the drug delivery. Oral drug delivery is the most comforting method of delivery due to its comforting method of delivery, due to its better solubility, accurate dosage and simpler production. Approximately 90% of the drugs are administered orally of which solid oral dosage form is the most chosen class of medicaments. Conventional dosage forms usually exhibit the serum drug concentration fluctuations an

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17

Patil, Nilesh Sureshrao, and Kishor Salunkhe. "FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ATORVASTATIN USING STATISTICAL DESIGN (JMP SOFTWARE)." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 19–25. http://dx.doi.org/10.22270/jddt.v9i4-a.3284.

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More complications and cost of promoting of imaginative drugs are more prominent consideration to the improvement of controlled release (CR) drug delivery systems. Sustained release or controlled release drug delivery system helps to reduced toxicity of drug and more patient compliant drug delivery system. The aim of this study is to have efficient means of manufacturirng of Gastro retentive floating tablet of Atorvastatin Calcium. Atorvastatin is used in the treatment of hyperlipidaemia. Oral bioavailability of atorvastatin calcium is less than 12% due to instability and in complete absorptio

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18

Harshdeep, Desai* Tushar Rukari Rashmi Mahabal Dr. Vijay Jagtap. "Beyond Conventional: Recent Advancement on Floating Drug Delivery Systems: An Approach to Oral Controlled and Sustained Drug Delivery Via Gastric Retention." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2971–94. https://doi.org/10.5281/zenodo.14546659.

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Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, High-Density Systems, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS.

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19

Patole, Rutuja, Bharatee Chaware, Vishal Mohite, and Vivekkumar Redasani. "A Review for Gastro - Retentive Drug Delivery System." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 79–94. http://dx.doi.org/10.22270/ajprd.v11i4.1291.

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Inadequate pharmacokinetic properties may be connected with the widespread use of oral dose forms in disease treatment. Because of the formulation's rapid transit through the gastrointestinal tract (GIT), it can be challenging to achieve therapeutic levels of the medicine in specific situations when it is barely soluble; In addition, some medications must work locally due to a gastric disease, although they only last a short period in the stomach. Numerous studies have been done to identify formulations that can enhance all of these characteristics while extending stomach residence time. Many

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20

Hamdi, Dalia S., Masar B. M. Mohamed, and Saja M. Mansour. "Preparation and Characterization of Hydroxypropyl methylcellulose Gastroretentive Film using Metoclopramide HCl." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1831–37. http://dx.doi.org/10.25258/ijddt.12.4.57.

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This study aimed to formulate a gastro retentive slow release dosage form based on oral film for metoclopramide hydrochloric acid (HCl), a medication with a narrow absorption window. The gastroretentive film was made using a solvent casting method with varying ratios of primary polymers (HPMC 15000 cps and HPMC K4M), secondary polymer (carbopol 934), and PEG-400 as a plasticizer. The film of hydroxypropyl methylcellulose (HPMC) K4M-3 (50:50) (HPMC K4M: carbopol) was buoyant for 20 minutes. The 52 wt % of metoclopramide HCl (metclo) was released from the HPMC K4M-3 film after 24 hours, and its

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Singh, Akhilesh Kumar, and Neeraj Sharma. "Future outlook hydrodynamic drug delivery system of solid oral dosage form: Review." IP International Journal of Comprehensive and Advanced Pharmacology 6, no. 3 (2021): 96–101. http://dx.doi.org/10.18231/j.ijcaap.2021.018.

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Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that

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22

Kumar, Manmeet, Prashanta Bose, Amar Pal Singh, and Ajeet Pal Singh. "Design and Evaluation of Gastro-Retentive Floating Tablets of Etidronate disodium." International Journal of Medical Sciences and Pharma Research 11, no. 1 (2025): 45–51. https://doi.org/10.22270/ijmspr.v11i1.140.

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Osteoporosis raises the chance of breaking a bone strength. It is the most frequent cause of fractures in the elderly. The hip, forearm, and back bones are among the bones that break most frequently. Usually, there are no symptoms until a broken bone happens. In order to target site-specific drug release in the upper GIT for a local or systemic effect, GRDDs are a method of extending the gastric residence time. For a very long time, gastro retentive dosage forms (GRDFs) have been used to enhance treatment with a number of significant medications. Paget's disease is a particular kind of bone di

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Datir, S. K., P. B. Patil, and R. B. Saudagar. "Floating type drug delivery system: a review." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 428–32. http://dx.doi.org/10.22270/jddt.v9i2.2492.

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Floating Type drug delivery system retains the dosage form for a long span. They provide local delivery to specific region like stomach and proximal small intestine and shows better bioavailability and improve therapeutic activity and substantial benefit to patients. FDDS is one of the novel drug delivery system to prolong gastric retention time. Various forms of gastro retentive drug delivery system, such as floating and non- floating. Keywords: Floating Drug Delivery System, Classification effervescent, non-effervescent, and Factors affecting FDDS.

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Nesterenko, V. G., R. N. Bolgarin, B. A. Rudoy, et al. "Development of a Gastro-retentive Dosage Form of a New Promising Anti-tuberculosis Drug Macozinone." Drug development & registration 10, no. 3 (2021): 55–69. http://dx.doi.org/10.33380/2305-2066-2021-10-3-55-69.

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Introduction. Due to increase in the frequency of detecting cases of tuberculosis caused by strains of mycobacteria with resistance not only to traditional, but also recently introduced into clinical circulation anti-tuberculosis drugs, it is urgent to search for and develop new drugs that can be effective against multidrug-resistant (MDR-TB) and extensively drug resistant (XDR-TB) strains. One of the most promising classes of such compounds are fluorine derivatives of benzothiazinones, and particularly compound PBTZ169 (INN macozinone). This antibiotic has a high specificity against mycobacte

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SHARMA, RAJESH, and ASHWANI MISHRA. "DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE TABLETS OF CLARITHROMYCIN FOR ANTIULCER EFFECT." Current Research in Pharmaceutical Sciences 12, no. 1 (2022): 40–45. http://dx.doi.org/10.24092/crps.2022.120106.

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Gastroretentive floating drug delivery system (GFDDS) is used to prolong the gastric residence time after oral administration, at a particular site and controlled or modified the release of drug from the formulation.The purpose of the present study is to develop a gastro retentive floating drug delivery system to achieving controlled release so that is improves bioavailability of the formulation, Structure activity relationship based on Biopharmaceutical Properties of Clarithromycin indicates good biopharmaceutical Properties. Floating dosage form of Clarithromycin was designed for the treatme

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Jain, AbhishekKumar, CP Jain, YS Tanwar, and PS Naruka. "Formulation, characterization andin vitroevaluation of floating microspheres of famotidine as a gastro retentive dosage form." Asian Journal of Pharmaceutics 3, no. 3 (2009): 222. http://dx.doi.org/10.4103/0973-8398.56302.

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Golla Anjali Yadav, Jhancy Laxmi bai, and V. Algarswamy. "Evaluating the neonatal formulation of famotidine in a live setting." International Journal of Allied Medical Sciences and Clinical Research 12, no. 4 (2024): 496–503. https://doi.org/10.61096/ijamscr.v12.iss4.2024.496-503.

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Oral controlled release (CR) dosage forms (DFs) have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration, patient compliance and flexibility in formulation. However, this approach is bedilled with several physiological difficulties such as inability to restrain and locate the controlled drug delivery system within the desired region of the gastrointestinal tract (GIT) due to variable gastric emptying and motility. Furthermore, the relatively brief gastric emptying time (GET) in humans which normally averages 2-3 through the

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D., Jeslin*, Anusri S., Ashwini P., et al. "GASTRO RETENTIVE DOSAGE FORMS: A COMPREHENSIVE REVIEW OF DESIGN STRATEGIES AND THERAPEUTIC BENEFITS." World Journal of Pharmaceutical Science and Research 3, no. 6 (2024): 41–52. https://doi.org/10.5281/zenodo.14252428.

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GRDDS have emerged as a promising solution for overcoming the challenges associated with conventional oral dosage forms, particularly the issue of unpredictable gastric emptying times and reduced bioavailability of drugs that are preferentially absorbed in the upper gastrointestinal tract. These systems are intended to extend the duration of the drug absorption in the stomach, thereby improving the bioavailability and subsequent therapeutic efficacy of the medication. The formulation GRDDS type of medication reduce the frequency of dosing by controlling the factors affecting gastric residence

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Raut, Yogesh Baburao, Kalyan Chakravarthy Janjanam, Trinayan Deka, et al. "Development, Optimization and Evaluation of Gastro-Retentive Microspheres of Antidiabetic Agent by Full Factorial Design." Chinese Journal of Applied Physiology 40 (2024): e20240019. http://dx.doi.org/10.62958/j.cjap.2024.019.

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Objective: This work is aimed to Formulate, Optimize and Evaluate Gastro-Retentive Microspheres of Antidiabetic Agent by Full Factorial Design. Methods: Microspheres were prepared using Emulsification-cross linking technique. To this HPMC-K4M and Carbopol was dissolved in 250 ml of water and allowed to swell for 24 hr at room temperature. And separately chitosan was dissolved in 3% (v/v) glacial acetic acid and this also kept for 24 h to swell or dissolve properly. After 24hr this swelled mixture was mixed under magnetic stirrer (Remi, India) at specific stirring rate for 1hr in order to find

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Palekar, N. G., R. V. Keny, and V. A. Jagtap. "FORMULATION AND EVALUATION OF BUOYANT MICROSPHERES OF NIZATIDINE BY SPRAY DRYING TECHNIQUE." INDIAN DRUGS 55, no. 01 (2018): 81–83. http://dx.doi.org/10.53879/id.55.01.10933.

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The objective of the present investigation was to formulate multiparticulate buoyant dosage form of nizatidine, a H2-receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, colonic metabolism of nizatidine favors, development of gastro retentive floating dosage form. Buoyant microspheres of nizatidine were prepared by spray drying technique using hydroxylpropyl methylcellulose and ethylcellulose as the rate controlling polymers. The prepared multiparticulate system were evaluat

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Kohli, Seema, Megha Sharma, and Abhisek Pal. "ETHYLCELLULOSE FLOATING MICROSPHERES OF ANTIDIABETIC AGENT: IN VITRO AND IN VIVO EVALUATION." International Journal of Applied Pharmaceutics 9, no. 1 (2016): 44. http://dx.doi.org/10.22159/ijap.2017v9i1.16139.

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Objective: To develop and evaluate floating type gastro-retentive dosage form, appropriate for controlled release of repaglinide (RG) having a narrow therapeutic window.Methods: Repaglinide loaded microspheres (MS) using biological macromolecule ethylcellulose (EC) was prepared by a solvent diffusion-evaporation technique using polyvinyl alcohol (PVA) emulsifier. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). During formulation, various process optimisation parameters studied were stirring speed, the concentration of drug, polymer and emulsifie

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Kukati, L., K. Chittimalli, and N. B. Shaik. "Formulation and Evaluation of Floating Tablets of Cefpodoxime Proxetil." Journal of Scientific Research 6, no. 3 (2014): 563–79. http://dx.doi.org/10.3329/jsr.v6i3.18339.

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In the present investigation, an attempt was made to develop gastro retentive tablets of cefpodoxime proxetil (CP) using locust bean gum as release retarded material. CP is an orally administered, extended spectrum, semi-synthetic antibiotic of cephalosporin class. CP has a short elimination half-life and also possesses high solubility, chemical, enzymatic stability and absorption profiles in acidic pH which makes CP suitable candidate for formulating it as gastro retentive dosage form for improved bioavailability. Sodium bicarbonate and citric acid were used as effervescent agents to get desi

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P, Poornima, Abbulu K, and Mukkanti K. "Design and Preclinical Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumerate." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4122–28. http://dx.doi.org/10.37285/ijpsn.2018.11.3.6.

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The present study was focused on gastro-retentive tablets of quetiapine fumarate using hydrophilic polymers HPMC K250 PH PRM, HPMC K750 PH PRM and HPMC K1500 PH PRM as release retarding agents. WSR 301 was chosen as resin, sodium bicarbonate was used as effervescent agents. FTIR studies revealed that there is no interaction between the drug and polymers used for the formulation. The tablets were prepared by direct compression method and the release rate was found to decrease with proportional increase in the ratio of polymer to drug. Quetiapine fumarate is absorbed well from stomach and theref

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Goindi, Shishu, Kamalpreet Mann та Nidhi Aggarwal. "Gastro-retentive floating beads of curcumin β-cyclodextrin complex to treat stomach tumors". Alternative Medicine Studies 1, № 1 (2011): 12. http://dx.doi.org/10.4081/ams.2011.e12.

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The aim of present study was to develop a multi-unit gastro-retentive floating dosage form of curcumin with targeted and sustained release characteristics. Although, protective effect of curcumin against inflammation and cancer is well documented, the clinical potential is underutilized owing to the physicochemical properties of the molecule which lead to poor oral bioavailability. Aqueous solubility of curcumin was enhanced by complex formation with β-cyclodextrin (β-CD). This complex with enhanced solubility profile was further used to prepare multiple unit floating beads. Floating beads of

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Mehta, Gagandeep, Rajesh Kumar, Ajeet Pal Singh, and Amar Pal Singh. "Design and Evaluation of Gastro-Retentive Floating Tablets of Ibandronic acid." Journal of Drug Delivery and Therapeutics 14, no. 5 (2024): 122–29. http://dx.doi.org/10.22270/jddt.v14i5.6576.

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The objective of this study is Preparation and evaluation of gastro-retentive floating tablets of Ibandronic acid by direct compression method polymers or combination. In this study, Ibandronic acid, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastro retentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDDs are an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper GIT for local or systemic effect. GRDF tablets of Ibandronic acid (200 mg) were characterized with the effects of Carbopo

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Parmar, Lokesh, Mansi Gupta, and Geeta Parkhe. "FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF MEBENDAZOLE AS A GASTRO RETENTIVE DOSAGE FORM." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 311–14. http://dx.doi.org/10.22270/jddt.v8i5-s.1980.

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The present study involves preparation and evaluation of floating microspheres using Mebendazole (MBZ) as a model drug for improving the drug bioavailability by prolongation of gastric retention time. Ethyl cellulose, hydroxyl propyl methyl cellulose microspheres loaded with mebendazole were prepared by solvent diffusion evaporation method. The microspheres had smooth surfaces, with free-flowing and good-packing properties. The yield of the microspheres was up to 85.65±0.14% and ethyl cellulose microspheres entrapped the maximum amount of the drug. Scanning electron microscopy confirmed their

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Yadav, RK, Satyam Prakash, K. Yadav, NK Yadav, and M. Mostafa. "Physico-chemical evaluation of Gastroretentive Ranitidine Hydrochloride: An Anti-Ulcer Drug." Janaki Medical College Journal of Medical Science 3, no. 2 (2016): 4–12. http://dx.doi.org/10.3126/jmcjms.v3i2.16075.

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Background and Objectives: The prevention and treatment of peptic ulcers has become an important challenge in the current medicine world. Modern progress in novel drug delivery system aims to improve the efficacy of the drug molecule by formulating a dosage form of RHCL. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in GI tract is to control the gastric residence time. Therefore, a multi-unit gastro retentive dosage form of RHCL capable of floating on simulated gastric fluid for more than 12 hours was formulated and evaluated.Materials and

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Chavhan, Divya, Ram D. Bawankar, and Mundhada DR. "A Gastro Retentive Drug Delivery System of Perindopril using Natural Polymer – Development and Optimization." International Journal of Ayurvedic Medicine 16, S2 (2025): 116–23. https://doi.org/10.47552/ijam.v16is2.6170.

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Gastro retentive floating matrix tablet provides drug delivery at the controlled rate, improve bioavailability and prolong the retention of dosage forms in gastrointestinal tract. Okra gum, a mucilage-rich extract derived from the okra plant (Abelmoschus esculentus), holds significant value in both Ayurvedic medicine and modern pharmaceutical sciences. Knowing the importance of Okra gum, aim of present investigation is to develop gastro retentive floating matrix tablet of Perindopril using Avicel pH 102 as a directly compressible material; Citric acid for production of acidic microenvironment

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Thakur, Shobhana, Dolly Jain, and Shiv Kumar Prajapati. "DEVELOPMENT AND CHARACTERIZATION OF SUSTAINED RELEASE GASTRO-RETENTIVE FLOATING TABLETS OF AMBROXOL HYDROCHLORIDE." INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 4, no. 1 (2022): 43–49. http://dx.doi.org/10.37021/ijper.v4i1.6.

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Introduction: The objective of this study was to formulate floating tablets of Ambroxyl hydrochloride (AMB HCl) using the dry granulation technique to increase its bioavailability and the gastric residence time (GRT) of the dosage form. Materials and Methods: The gastro-retentive floating tablets of Ambroxol hydrochloride (AMB HCl) were prepared by direct compression method using different concentrations of polymers such as HPMC K4, HPMC K15 and PVP K30, gas releasing agents (Sodium bicarbonate and citric acid) and diluents (Microcrystalline cellulose). Citric acid was also used as an antioxid

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Thakur, Sanjay, Krishnappa Ramya, Deepak Kumar Shah, and Khadga Raj. "Floating Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 125–30. http://dx.doi.org/10.22270/jddt.v11i3-s.4828.

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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of

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Navneet, Kumar Verma. "Introduction and Application of Bilayer Floating Tablet: A Brief Review." International Journal of Medical and Pharmaceutical Research 2, no. 2 (2023): 37–45. https://doi.org/10.5281/zenodo.8151947.

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Bilayer tablet is an innovation period for the successful advancement of controlled release formulation as well as a variety of features to produce a successful drug delivery system technique. Controlled release dose forms have been widely employed to improve treatment with a number of key medications. Inclusion of drugs in controlled release gastro-retentive dosage forms that can remain in the gastric region for several hours would significantly increase drug bioavailability, reduce drug waste, and improve the solubility of drugs that are less soluble in high pH environments. Floating drug de

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Shep, Santosh, Sham Dodiya, Sandeep Lahoti, and Rahul Mayee. "Swelling System: A Novel Approach Towards Gastroretentive Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 01, no. 03 (2011): 234–42. http://dx.doi.org/10.35652/igjps.2011.23.

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Swelling Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. Swelling drug delivery systems is the system which is retained in the st

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Nagare, Hrishikesh Sandipan Shendge Raosaheb S. Halnor Vishal V. "REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1439–47. https://doi.org/10.5281/zenodo.1199052.

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The oral delivery system is the mostly preferable route of drug delivery because easy to administered, non-evasive in nature, flexibility in formulation and patient compliance. Gastro retentive drug delivery system (GRDD) improve the bioavailability of drug, therapeutic efficacy and reduce the dosing frequency. Drug absorption in GIT is a high variable procedure and such it depends upon the factors like absorption of drug on site, drug release from the dosage form, gastrointestinaltransit time of dosage forms and gastric emptying process.gastroretentive dosage forms remain in the gastric regio

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Dharmajit, Pattanayak* Dr. Ramesh Adepu Saumya Das Ramya Sri Sura. "A SYSTEMIC REVIEW ON FLOATING MUCOADHESIVE DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2970–78. https://doi.org/10.5281/zenodo.1231047.

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Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity.The floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence t

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Mishra, Sri Prakash, Amit Nayak, Dinesh Kumar Mishra, and Abhay Kumar. "Gastroretentive Mucoadhesive Microsphere for the Management of Gastric Infection." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 680–86. http://dx.doi.org/10.22270/jddt.v9i4-s.3357.

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Gastric infections are mostly triggered by Helicobacter pylori (H. pylori), a fungus that colonizes the stomach mucosa of more than 50% of the inhabitants of the world. Chronic H. Pylori diseasewas associated with stomach diseases such as peptic ulcer, chronic gastritis and stomach adenoc arcinoma. Current therapy for eradication relies on antibiotic-based therapies that are ineffective in about 20% of patients. Traditional method constraints optimize the creation of new techniques for fast, consistent and cost-effective H diagnosis. Infection with pylori. Wide-ranging study has been carried o

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Panda, Subhranshu, C. H. Surya Kumari, and G. Puniya. "FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 6 (2018): 82. http://dx.doi.org/10.22159/ijpps.2018v10i6.25367.

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Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disint

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Pakhale, Nilesh V., S. B. Gondkar, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 836–38. http://dx.doi.org/10.22270/jddt.v9i3-s.2817.

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Effervescent floating drug delivery systems release gas CO2, thus reduce the density of the system and remain buoyant in the stomach 2 for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss in detail about effervescent agent and mechanism of effervescent floating drug delivery system. Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal

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Rajagopalan, Senthamarai, Dinesh Rajendhiran, Ismail Abdulrahim Mohamed, and Shakila Banu Sherbudeen. "Fast dissolving oral thin films: an innovative herbal drug delivery system." International Journal of Research in Medical Sciences 12, no. 8 (2024): 3085–90. http://dx.doi.org/10.18203/2320-6012.ijrms20242250.

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Fast-dissolving drug delivery systems were first developed as an alternative to common dosage forms in the late 1970s. The oral thin film is an innovative drug administration approach based on transdermal patch technology. These systems consist of solid dosage forms that dissolve and disintegrate quickly in the mouth without the need for water. Oral thin films (OTFs) and oral disintegrating tablets (ODTs) are two types of fast-acting pharmaceutical delivery methods. ODTs are "A solid dosage form containing medicinal substances, which disintegrates rapidly, usually within a matter of seconds, w

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Kumar, Vishal, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, and Shammy Jindal. "A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet." Asian Journal of Research in Pharmaceutical Sciences 11, no. 3 (2021): 237–46. http://dx.doi.org/10.52711/2231-5659.2021.00038.

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Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet, stable over extended and diverse storage conditions, can be produced on high-speed compression, labelling, and packaging equipment. Advancements in technology and modification in standard compressed tablet are to achieve better acceptability as well as bioavailability. Various types of newer and more efficient tablets are developed to create a delivery system that is relatively simple to administration. In one sense osmotic pump systems are an

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Pallavi, T., G. S. Sharma, B. Rama, L. Jyothi Rani, and B. Rajkamal. "Formulation and evaluation of floating bilayer tablets of epleronone." World Journal of Pharmaceutical Sciences 10, no. 04 (2022): 08–17. http://dx.doi.org/10.54037/wjps.2022.100402.

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Gastro retentive drug delivery systems have been widely used to prolong retention of dosage forms in stomach. Among the various approaches, the floating bilayer tablets formulation offers sustained drug release as well as prolonged gastric retention, along with the added advantage of liquid oral dosage form. The present study was an attempt to formulate and evaluate floating bilayer tablets of Epleronone by using various polymers like guar gum, ethyl cellulose, SSG, CCS. The prepared floating Bilayered tablets were evaluated for hardness, Weight variation, thickness, friability, drug content u

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