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Academic literature on the topic 'Gastro Retentive Floating Drug Delivery Systems'

Author: Grafiati
Published: 5 June 2025
Last updated: 24 June 2025

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Journal articles on the topic "Gastro Retentive Floating Drug Delivery Systems"

1

Gauri, R. Dhamale1 Harshali L. Shelke2 Priti B. Shinde3 Rohini R. Khedkar4 Preeti P. Rohokale5 Dr. Jeevan R. Rajguru6. "Gastroretentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1825–40. https://doi.org/10.5281/zenodo.12818744.

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The aim of this review on gastroretentive drug delivery systems is to gather and present recent literature, particularly highlighting the various gastroretentive methods that have recently emerged as prominent techniques in the realm of site-specific, orally administered, controlled release drug delivery. Floating drug delivery systems represent advanced technology that allows these systems to float on gastric fluids, potentially enhancing the bioavailability and intestinal absorption of encapsulated drugs. The effectiveness of these systems depends on both physiological and formulation factors that influence gastric retention, essential for the successful development of floating drug formulations. These systems can be categorized into single-unit or multiple-unit floating designs. By extending and managing the rate of gastric emptying, these formulations support prolonged drug release. Gastro-retentive systems extend the residence time in the stomach, improving drug bioavailability and solubility in higher pH conditions, and ensuring maximum drug concentration at the target site. This review explores different gastro-retentive drug delivery systems, including those made from natural and synthetic polymers, and their applications. It also highlights the factors impacting these systems, as well as the challenges in the process and future prospects for their commercialization. 
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2

chilukala, Swathi. "Gastro retentive Drug Delivery of Cyclobenzaprine Hydrochloride." Gastroenterology Pancreatology and Hepatobilary Disorders 2, no. 1 (2018): 01–03. http://dx.doi.org/10.31579/2641-5194/006.

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Drugs that are easily absorbed from the GI tract and have a short half-life are eliminated quickly from the blood circulation, require frequent dosing. To avoid this problem, the oral controlled release formulations are being developed. Gastro-retentive dosage forms have the potential from use as controlled release systems. The purpose of this research is to develop the gastro retentive drug delivery system of centrally acting alpha adrenergic agonist cyclobenzaprine Hydrochloride (cyclobenzaprine HCl). It is well absorbed from the upper part of the GIT, due to short gastric residence time the bioavailability is low and hence it is need to develop a dosage form that releases the drug in stomach using gastro retentive system. Different formulations of cyclobenzaprine HCl gastro-retentive floating tablets were prepared by wet granulation method using various concentrations of HPMC K4M / HPMC K100M and combination of Psyllium husk and HPMC K100M as matrix forming agent. Sodium bicarbonate and citric acid were used as a gas generating agent that helps in maintaining the buoyancy. The prepared cyclobenzaprine HCl gastro-retentive floating granules were subjected to pre-compression properties to comply with pharmacopoeial limits and the prepared gastro-retentive floating tablets were characterized for weight variation, hardness, thickness and friability drug content, swelling studies. The floating lag time of all formulation is good and the Total floating time of all the formulations was >12 hours. The tablets were evaluated for in vitro release characteristics for 12hrs in 0.1N HCl at 37 oC and from this in vitro release studies the formulations F-5, F-9 and F-15 exhibited good controlled release profile of about 96.0%, 94.5% and 95.0% when compared with other formulations while floating on the dissolution medium.
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3

Chandra, Ayan, Krishnendu Dakua, Annesha Sarkar, and Sumit Prasad Bhakat. "Advancements in Gastro Retentive Drug Delivery Systems: Optimizing Drug Efficacy and Prolonging Gastric Retention– A Review." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 360–67. https://doi.org/10.35629/4494-0905360367.

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Gastro Retentive Drug Delivery Systems (GRDDS) is a very unique and developed method of the drugdelivering system that is designed to keep drugs in the stomach for a longer time, increasing drug absorption and effectiveness. These systems are particularly useful for drugs that have optimal absorption in the stomach or broken down in the intestines. Gastro Retentive Drug Delivery Systems use methods such as Floating, Swelling, Mucoadhesive, High-Density, Magnetic and RaftForming methods for optimizing effectiveness, targeted and controlled drug release that increases the gastric retention time of the drugs. Although Gastro Retentive Drug Delivery Systems have many benefits, such as better drug absorption, localised treatment, and reduced dosing frequency, they also have limitations, such as gastric emptying, pH changes, enzymatic degradation, and patient variability that affect the therapeutic of the drug. Recent advances in 3D printing technology and AIdriven drug manufacturing are increasing the efficiency and customization of Gastro Retentive Drug Delivery Systems.
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4

Waghmare, Suchita Gulabrao, Pramod B. Khedekar, and Jayshree R. Aate. "HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough." ECS Transactions 107, no. 1 (2022): 12229–40. http://dx.doi.org/10.1149/10701.12229ecst.

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Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying to reduce the dosing frequency. Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Present study involves preparation of floating tablet of Guaifenesin with HPMC K10 and K15M floating tablet were designed to achieve the extended release or retention in GIT, which may result enhance in absorption and leads to increase in bioavaibility. The aim of the present work is to develop safe, effective HPMC based gastro retentive drug delivery system of effervescent Guaifenesin tablet for dry cough with extended release profile.
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5

Maniyar, M. M., P. B. Patil, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A Review." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 771–72. http://dx.doi.org/10.22270/jddt.v9i4-a.3561.

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Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours.these systems are useful for many of the problem occurred during development of pharmaceutical dosage form. The objective of the review is to understand the current approaches of this drug delivery system.
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Kumar, Surender, Jagtar Singh Chohan, Harwinder Kaur, Rishabh Kasnia, Sunaina Demiwal, and Bhupender Nehra. "An Updated Overview of Gastro-retentive Floating Drug Delivery Systems: Formulation Strategies and Application." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 175–82. http://dx.doi.org/10.22270/jddt.v14i8.6726.

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Gastro-retentive floating drug delivery systems (GRFDDS) have emerged as a significant advancement in enhancing the bioavailability and therapeutic efficacy of various medications. This review article provides a comprehensive overview of recent innovations in GRFDDS, highlighting their formulation strategies, mechanisms of buoyancy, and various applications in drug delivery. The role of various polymeric materials, gas-forming agents, and optimization techniques is discussed which are generally employed to develop effective floating systems. Additionally, keen insight is brought on applications of GRFDDS in treating gastrointestinal disorders, enhancing the pharmacokinetics of drugs with narrow absorption windows, and their potential in controlled-release formulations. In this review, authors compiled the recent reported literatures about the gastro-retentive floating drug delivery systems since 2015 to underline the effectiveness and safety profiles of these systems. This review aims to consolidate current knowledge and inspire future research directions in the development of GRFDDS for improved patient outcomes. Keywords: Floating; Gastro-retentive; drug delivery; HPMC; Effervescent
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7

Kumar, Abhishek, and Meenakshi Bharkatiya. "A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 1 (2021): 5257–70. http://dx.doi.org/10.37285/ijpsn.2021.14.1.1.

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Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. In this context, various gastro retentive drug delivery systems have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Various approaches are currently used including gastro retentive floating drug delivery systems, swelling and expanding system, polymeric bio adhesive systems, modified shape systems, high density system and other delayed gastric emptying devices. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres. Attempt has been made to summarize important factors controlling gastro retentive drug delivery systems. Overall, this review may inform and guide formulation scientists in designing the gastro retentive drug delivery system.
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Bisht, Latika, Tarun Parashar, Mansi Butola, and Vikash Jakhmola. "A Panoramic Review on Gastro-Retentive Floating Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 1239–47. http://dx.doi.org/10.25258/ijddt.14.2.91.

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Floating drug delivery has been demonstrated to be the most efficacious of the numerous gastroretentive drug delivery mechanism strategies. The concept behind this system has drawn substantial interest in recent decades. Several strategies are currently implemented to prolong the stomach residence durations, such as floating drug delivery systems, swelling and expansion systems, polymer bioadhesive systems, deformation systems, high-density, etc., systems, and various delayed emptying gastric devices. From a formulation and technology standpoint, floating drug delivery equipment is a rather simplistic and straightforward approach. Floating delivery of drug systems is one of the GRDFs used to increase stomach residence duration. The floating medication delivery device can persist in the gastrointestinal region for several hours due to its floating action on the stomach contents, extensively enhancing the gastrointestinal residence period of drugs. The main thrust of this review is on the design, factors, characterization, applications, evaluation criteria, and prospective future gastro-retentive floating medication delivery techniques.
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9

Kajal, D. Chaudhari, G. Nimbalwar Minakshee, S. Singhal Nikita, A. Panchale Wrushali, V. Manwar Jagdish, and L. Bakal Ravindra. "Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system." GSC Advanced Research and Reviews 7, no. 1 (2021): 035–44. https://doi.org/10.5281/zenodo.4726586.

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Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.
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10

Pant, Shailaja, Ashutosh Badola, and Preeti Kothiyal. "A review on gastroretentive drug delivery system." Indian Journal of Pharmaceutical and Biological Research 4, no. 2 (2016): 01–10. http://dx.doi.org/10.30750/ijpbr.4.2.1.

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Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. In this review we have been discussed various approaches of gastro retentive drug delivery system, such as floating and non-floating systems.
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Book chapters on the topic "Gastro Retentive Floating Drug Delivery Systems"

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Rajpoot, Kuldeep, Sunil K. Jain, and Saroj Dangi Rajpoot. "Gastro-retentive Nanocarriers in Drug Delivery." In Nanoparticles and Nanocarriers-Based Pharmaceutical Formulations. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815049787122010009.

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The oral route is an extremely accepted route for the administration of several drug delivery systems. This route exhibits several merits for the controlled and sustained release of different formulation types to attain enhanced therapeutic responses. Gastro-retentive nanocarriers (NCs) (GRNCs) have advantages due to their aptitude for extended retaining potential in the stomach environment and thereby elevate gastric retention and augmenting bioavailability of the drug molecules. This chapter covers various merits and demerits of gastro-retentive NCs. Further, it also discusses some gastro-retentive strategies and their applications in the therapy of various illnesses, for instance, swelling NCs, porous NCs, floating/non-floating NCs, lipid NCs, Polymeric NCs, bioadhesive NCs, and magnetic NCs, etc.
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Pavan, A. Rajesh, Gorantla Naresh Babu, and Dr S. B. Thirumalesh Naik. "FLOATING MICROSPHERES A NEW TREND IN THE DELIVERY OF GASTRO RETENTIVE MEDICATIONS." In Futuristic Trends in Pharmacy & Nursing Volume 2 Book 25. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2023. http://dx.doi.org/10.58532/v2bs25p1ch5.

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There is no control over the delivery of conventional dose forms. Gastric resident time and gastric emptying are two crucial parameters that have a substantial impact on the drug's ability to treat certain conditions, and it produces differences in the drug's retention period. Drug levels in plasma change depending on the dosing type. As a result, among all gastro-retentive medication administration methods, the floating microsphere is one of the most dependable and creative methods to solve these issues. Due to their extreme appropriateness for targeting, floating microspheres are primarily gaining relevance. The main reason floating microspheres are becoming more and more popular is because of how well-suited they are for delivering medications to the stomach, dispersing them evenly over the gastric fluid to prevent variations in gastric emptying, and increasing drug release. Additionally, this technique greatly facilitates the development of oral formulations with controlled and delayed releases fostering changes in the pharmaceutical sector. The anatomy and physiology stomach, intestines, and components govern the retentive medication delivery method, according to the current review. This review's objective is to shed light on the latest literature regarding the value of Microspheres that float in new medication delivery systems, Formulation techniques, classification, and recent scientific developments in the formulations of floating microspheres using various drug classes
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Firke, Sagar N., Ashish B. Roge, Pritam R. Siraskar, and Nitin B. Ghiware. "A Review on Floating Microspheres as Gastro-retentive Drug Delivery System." In Current Overview on Pharmaceutical Science Vol. 1. B P International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/cops/v1/17077d.

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4

"Drug Delivery: Gastro-Retentive Systems." In Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition. CRC Press, 2013. http://dx.doi.org/10.1081/e-ept4-120041584.

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Hoffman, Amnon, and Bashir A. Qadri. "Drug Delivery: Gastro-Retentive Systems." In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Taylor & Francis, 2016. http://dx.doi.org/10.1081/e-ebpp-120041584.

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AJMAL, Dr GUFRAN, and Prof ANUPAMA DIWAN. "IN-VITRO AND IN-VIVO EVALUATIONS OF GASTRO-RETENTIVE DRUG DELIVERY SYSTEMS." In NOVEL DRUG DELIVERY SYSTEM. GRF BOOKS, 2022. http://dx.doi.org/10.52458/9789391842871.2022.eb.grf.asu.ch.05.

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7

Patel, Anand J., Bhavin R. Patel, and Pranav Shah. "Nanofibers Approach for Gastro Retentive Cancer." In Role of Nanotechnology in Cancer Therapy. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079999123010012.

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Gastric cancer is the world's second leading cause of cancer-related death. Due to inadequate drug release and limited residence time at the absorption site, traditional oral dose forms have poor/low bioavailability. GRDDS is particularly useful for increasing the bioavailability of medications with a narrow absorption window in the gastrointestinal tract and for treating local diseases. Polymeric nanofibers have sparked a lot of attention among the numerous nanomaterials used in high-tech applications because of their simplicity of production, controlled size/shape, and characteristics. Filtration, barrier fabrics, wipes, personal care, and biological and pharmaceutical applications have been intensively researched with polymeric nanofibers. Electrospun polymeric nanofibers have recently been demonstrated to be a promising approach for drug delivery systems. The nanofiber method allows for stomach-specific drug release for a more extended period and improves local drug action due to the drug's extended contact time with the gastric mucosa. As a result, nanofiber technology appears to be a promising strategy for gastric retention drug delivery systems.
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8

Srikar, Grandhi, and I. Nagamma. "Quality by Design Approach for Optimization and Development of Gastro-Retentive Hollow Microspheres for Prasugrel." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00414.

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Prasugrel (PSG) is used in minimizing the risk of atherothrombotic events in people with cardiovascular problems. Developing extended-release products for PSG is highly advantageous owing to its pharmacodynamic and pharmacokinetic properties. But, due to its insolubility in aqueous media with pH above 6.0, it becomes poorly bioavailable from the small intestine upon oral administration. Hence, an extended-release formulation which resides in gastric region until released completely is highly recommended. Polymeric hollow-microspheres with inherent floating property without lag time are highly preferable for the PSG kind of drugs. Emulsion solvent evaporation-diffusion technique was explored in this work to develop microspheres inner pores/hollowness. Box-Behnken design (BBD) was employed to study the influence of various formulation and process factors on the critical quality attributes or responses of the PSG hollow-microspheres. Various formulations according to the BBD were developed and studied for quality control tests like floating time, surface morphology, entrapment efficiency, particles size, drug release rate. Surface morphology by scanning electron microscopy indicated big dents and protrusions on the surface indicating inner hollowness. Design of experiments analysis was performed to develop regression equations for every response with the factors. Design validation by ANOVA indicated that all the factors were significant in having influence on every response at p < 0.05. The optimized microspheres were found to have 91.8% entrapment efficiency; 94.5% floating even after 24 h; and extended drug release for more than 18 hours. Ethyl cellulose hollow-microspheres for PSG were successfully optimized and developed by adopting quality by design approach.
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