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1
Gauri, R. Dhamale1 Harshali L. Shelke2 Priti B. Shinde3 Rohini R. Khedkar4 Preeti P. Rohokale5 Dr. Jeevan R. Rajguru6. "Gastroretentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1825–40. https://doi.org/10.5281/zenodo.12818744.
Full textAbstract:
The aim of this review on gastroretentive drug delivery systems is to gather and present recent literature, particularly highlighting the various gastroretentive methods that have recently emerged as prominent techniques in the realm of site-specific, orally administered, controlled release drug delivery. Floating drug delivery systems represent advanced technology that allows these systems to float on gastric fluids, potentially enhancing the bioavailability and intestinal absorption of encapsulated drugs. The effectiveness of these systems depends on both physiological and formulation factors that influence gastric retention, essential for the successful development of floating drug formulations. These systems can be categorized into single-unit or multiple-unit floating designs. By extending and managing the rate of gastric emptying, these formulations support prolonged drug release. Gastro-retentive systems extend the residence time in the stomach, improving drug bioavailability and solubility in higher pH conditions, and ensuring maximum drug concentration at the target site. This review explores different gastro-retentive drug delivery systems, including those made from natural and synthetic polymers, and their applications. It also highlights the factors impacting these systems, as well as the challenges in the process and future prospects for their commercialization.
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chilukala, Swathi. "Gastro retentive Drug Delivery of Cyclobenzaprine Hydrochloride." Gastroenterology Pancreatology and Hepatobilary Disorders 2, no. 1 (2018): 01–03. http://dx.doi.org/10.31579/2641-5194/006.
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Drugs that are easily absorbed from the GI tract and have a short half-life are eliminated quickly from the blood circulation, require frequent dosing. To avoid this problem, the oral controlled release formulations are being developed. Gastro-retentive dosage forms have the potential from use as controlled release systems. The purpose of this research is to develop the gastro retentive drug delivery system of centrally acting alpha adrenergic agonist cyclobenzaprine Hydrochloride (cyclobenzaprine HCl). It is well absorbed from the upper part of the GIT, due to short gastric residence time the bioavailability is low and hence it is need to develop a dosage form that releases the drug in stomach using gastro retentive system. Different formulations of cyclobenzaprine HCl gastro-retentive floating tablets were prepared by wet granulation method using various concentrations of HPMC K4M / HPMC K100M and combination of Psyllium husk and HPMC K100M as matrix forming agent. Sodium bicarbonate and citric acid were used as a gas generating agent that helps in maintaining the buoyancy. The prepared cyclobenzaprine HCl gastro-retentive floating granules were subjected to pre-compression properties to comply with pharmacopoeial limits and the prepared gastro-retentive floating tablets were characterized for weight variation, hardness, thickness and friability drug content, swelling studies. The floating lag time of all formulation is good and the Total floating time of all the formulations was >12 hours. The tablets were evaluated for in vitro release characteristics for 12hrs in 0.1N HCl at 37 oC and from this in vitro release studies the formulations F-5, F-9 and F-15 exhibited good controlled release profile of about 96.0%, 94.5% and 95.0% when compared with other formulations while floating on the dissolution medium.
3
Chandra, Ayan, Krishnendu Dakua, Annesha Sarkar, and Sumit Prasad Bhakat. "Advancements in Gastro Retentive Drug Delivery Systems: Optimizing Drug Efficacy and Prolonging Gastric Retention– A Review." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 360–67. https://doi.org/10.35629/4494-0905360367.
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Gastro Retentive Drug Delivery Systems (GRDDS) is a very unique and developed method of the drugdelivering system that is designed to keep drugs in the stomach for a longer time, increasing drug absorption and effectiveness. These systems are particularly useful for drugs that have optimal absorption in the stomach or broken down in the intestines. Gastro Retentive Drug Delivery Systems use methods such as Floating, Swelling, Mucoadhesive, High-Density, Magnetic and RaftForming methods for optimizing effectiveness, targeted and controlled drug release that increases the gastric retention time of the drugs. Although Gastro Retentive Drug Delivery Systems have many benefits, such as better drug absorption, localised treatment, and reduced dosing frequency, they also have limitations, such as gastric emptying, pH changes, enzymatic degradation, and patient variability that affect the therapeutic of the drug. Recent advances in 3D printing technology and AIdriven drug manufacturing are increasing the efficiency and customization of Gastro Retentive Drug Delivery Systems.
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Waghmare, Suchita Gulabrao, Pramod B. Khedekar, and Jayshree R. Aate. "HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough." ECS Transactions 107, no. 1 (2022): 12229–40. http://dx.doi.org/10.1149/10701.12229ecst.
Full textAbstract:
Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying to reduce the dosing frequency. Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Present study involves preparation of floating tablet of Guaifenesin with HPMC K10 and K15M floating tablet were designed to achieve the extended release or retention in GIT, which may result enhance in absorption and leads to increase in bioavaibility. The aim of the present work is to develop safe, effective HPMC based gastro retentive drug delivery system of effervescent Guaifenesin tablet for dry cough with extended release profile.
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Maniyar, M. M., P. B. Patil, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A Review." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 771–72. http://dx.doi.org/10.22270/jddt.v9i4-a.3561.
Full textAbstract:
Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours.these systems are useful for many of the problem occurred during development of pharmaceutical dosage form. The objective of the review is to understand the current approaches of this drug delivery system.
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Kumar, Surender, Jagtar Singh Chohan, Harwinder Kaur, Rishabh Kasnia, Sunaina Demiwal, and Bhupender Nehra. "An Updated Overview of Gastro-retentive Floating Drug Delivery Systems: Formulation Strategies and Application." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 175–82. http://dx.doi.org/10.22270/jddt.v14i8.6726.
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Gastro-retentive floating drug delivery systems (GRFDDS) have emerged as a significant advancement in enhancing the bioavailability and therapeutic efficacy of various medications. This review article provides a comprehensive overview of recent innovations in GRFDDS, highlighting their formulation strategies, mechanisms of buoyancy, and various applications in drug delivery. The role of various polymeric materials, gas-forming agents, and optimization techniques is discussed which are generally employed to develop effective floating systems. Additionally, keen insight is brought on applications of GRFDDS in treating gastrointestinal disorders, enhancing the pharmacokinetics of drugs with narrow absorption windows, and their potential in controlled-release formulations. In this review, authors compiled the recent reported literatures about the gastro-retentive floating drug delivery systems since 2015 to underline the effectiveness and safety profiles of these systems. This review aims to consolidate current knowledge and inspire future research directions in the development of GRFDDS for improved patient outcomes. Keywords: Floating; Gastro-retentive; drug delivery; HPMC; Effervescent
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Kumar, Abhishek, and Meenakshi Bharkatiya. "A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 1 (2021): 5257–70. http://dx.doi.org/10.37285/ijpsn.2021.14.1.1.
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Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. In this context, various gastro retentive drug delivery systems have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. Concept of novel drug delivery system arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Various approaches are currently used including gastro retentive floating drug delivery systems, swelling and expanding system, polymeric bio adhesive systems, modified shape systems, high density system and other delayed gastric emptying devices. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. The present review briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. The purpose of this review is to bring together the recent literature with respect to the method of preparation, and various parameters affecting the performance and characterization of floating microspheres. Attempt has been made to summarize important factors controlling gastro retentive drug delivery systems. Overall, this review may inform and guide formulation scientists in designing the gastro retentive drug delivery system.
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Bisht, Latika, Tarun Parashar, Mansi Butola, and Vikash Jakhmola. "A Panoramic Review on Gastro-Retentive Floating Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 1239–47. http://dx.doi.org/10.25258/ijddt.14.2.91.
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Floating drug delivery has been demonstrated to be the most efficacious of the numerous gastroretentive drug delivery mechanism strategies. The concept behind this system has drawn substantial interest in recent decades. Several strategies are currently implemented to prolong the stomach residence durations, such as floating drug delivery systems, swelling and expansion systems, polymer bioadhesive systems, deformation systems, high-density, etc., systems, and various delayed emptying gastric devices. From a formulation and technology standpoint, floating drug delivery equipment is a rather simplistic and straightforward approach. Floating delivery of drug systems is one of the GRDFs used to increase stomach residence duration. The floating medication delivery device can persist in the gastrointestinal region for several hours due to its floating action on the stomach contents, extensively enhancing the gastrointestinal residence period of drugs. The main thrust of this review is on the design, factors, characterization, applications, evaluation criteria, and prospective future gastro-retentive floating medication delivery techniques.
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Kajal, D. Chaudhari, G. Nimbalwar Minakshee, S. Singhal Nikita, A. Panchale Wrushali, V. Manwar Jagdish, and L. Bakal Ravindra. "Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system." GSC Advanced Research and Reviews 7, no. 1 (2021): 035–44. https://doi.org/10.5281/zenodo.4726586.
Full textAbstract:
Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.
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Pant, Shailaja, Ashutosh Badola, and Preeti Kothiyal. "A review on gastroretentive drug delivery system." Indian Journal of Pharmaceutical and Biological Research 4, no. 2 (2016): 01–10. http://dx.doi.org/10.30750/ijpbr.4.2.1.
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Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. In this review we have been discussed various approaches of gastro retentive drug delivery system, such as floating and non-floating systems.
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Srinu, K., and S. Sravani. "A Review on Gastroretentive Drug Delivery System." International Journal for Research in Applied Science and Engineering Technology 12, no. 11 (2024): 2084–88. http://dx.doi.org/10.22214/ijraset.2024.65547.
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Abstract: Day by day the topic GRDDS has becoming popular due to its good therapeutic values and ease of cost of manufacturing. Gastro retentive drug delivery system is a type of retentive system it means which holds the drugs for prolonged time in GI fluid and release the drug in a controlled manner. And this article explores significance of GRDDS and its advantages over conventional system. This also focuses on the anatomy of stomach, introduction to GRDDS, criteria for selection of drug candidate for GRDDS, technologies of GRDDS. Keywords: Gastro-retentive, Controlled release , Site-specific drug delivery system , Drug targeting , GIT , Gastric retention Technology-related Keywords:- Hydro-dynamically balanced systems , Gas-generating systems , Floating drug delivery system. Application-related Keywords:- Diabetes management , Peptic ulcer treatment , Irritable bowel syndrome , Gastroesophageal reflux disease
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Pravin, Bhimrao Navgire Nilesh Paraji Musmade Amol rajendra Dhayarkar V. M. satpute Ghodake S. R. Gajanan Sanap. "Gastro Retentive Drug Delivery Systems: A Review." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 886–96. https://doi.org/10.5281/zenodo.11210033.
Full textAbstract:
In the current days, gastro retentive drug delivery systems (GRDDS) receive the great attention because they increase the performance of controlled release dosage forms, which can take orally. It is a widely employed technique to retain the dosage form in the stomach for a long period by releasing the drug slowly. These systems improved the patient compliance, which increases the therapeutic index of drugs. Various physiological barriers associated with the gastro retentive drug delivery systems such as short gastric retentive time, variation in gastric emptying time that can reduced by this technique. To formulate GRDDS various approaches like floating drug delivery systems, non-effervescent drug delivery systems, high density drug delivery systems, bioadhesive systems, magnetic systems, expandable systems etc.,. The present review mainly focuses on the requirements for formulating the GRDDS, various approaches involved in formulation and factors affecting gastric residence time.
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Nadigoti, Jagadeesh, and Shayeda. "Floating Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 595–604. http://dx.doi.org/10.37285/ijpsn.2009.2.3.2.
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Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature of single unit systems. Apart from the background, formulation aspects and evaluation of FDDS, recent developments are also covered in this review.
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Sanjib, Bahadur, Manisha Sahu, Baghel Pragya, Yadu Kamesh, and Naurange Tripti. "An overview on various types of gastroretentive drug delivery system." ScienceRise: Pharmaceutical Science, no. 6(28) (December 30, 2020): 4–13. https://doi.org/10.15587/2519-4852.2020.211931.
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Gastro retentive drug delivery system is one of the approaches to achieve controlled drug delivery. The gastro retentive drug delivery system is a way to prolong residence time of active pharmaceutical ingredient in gastrointestinal tract. It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Controlled drug delivery creates a window of absorption that release drug for a longer duration of time before reaching absorption site. Gastro retentive drug delivery systems have gained wide variation of oral drug distribution in the area of late. It includes all the approaches that keep the dosage form in the stomach for a longer duration of time. This also enables sustained release of active pharmaceutical ingredient which in turn overcomes many limitations of conventional drug delivery systems. It has begun tremendous advances in the field of gastro-retention to meet controlled release of drugs. <strong>Aim of research.</strong> The main aim of this survey to prolong the gastric retention dosage form in the stomach and improve the medication concentration in the stomach. <strong>Material and Method.</strong> To prepare this manuscript, various keywords were searched in different search engines such as Google, Yahoo, Bing etc. The available information in public domain was collected and classified according to delivery system. This review paper aim to provide complete information about different delivery systems related to Gastro retentive drug delivery systems (GRDDS). It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. <strong>Result.</strong> After going through various literatures, it can be said that the GRDDS can improve local bioavailability and therapeutic efficacy and dosing frequency possible reduction in dose size. This paper is focused on various physiological contemplation and obtainable formulation approaches for development of gastro retentive drug delivery system. <strong>Conclusions.</strong> This article discusses various types of GRDDS and their approaches. The gastric retentive drug delivery systems improve drug absorption. Prolonged gastric retention time of therapeutic mutations provide several benefits such as improving absorption, bioavailability and enhance the therapeutic action of drug
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Srivastava, Ankita, Ruchi Shukla, Kusum Sharma, Hitesh Jain, and D. B. Meshram. "Microballoons: A Gastro Retentive Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 625–30. http://dx.doi.org/10.22270/jddt.v9i4-s.3274.
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Oral route is most preferable and widely used route for the administration of drug. Microballoons becomes novel technology in pharmaceutical field in the floating drug delivery for achieving the gastric retention. Microballoons are also called as hollowspheres which are porous smooth in nature and thus show good floating properties in gastric fluid. Microballoons release the drug in controlled manner at the targeted site. Microballoons are spherical empty vesicles without core and that can remain buoyant in gastric region for prolong period of time without irritation in gastrointestinal tract. Multiparticulate particles having a low density system that can efficiently prolong the gastric retention time of the drugs, thus enhanced bioavailability and thus improve the dosing frequency. These are less soluble at higher pH environment. As microballoons delivery systems provide longer retention in gastric pH and enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microballoons depend on the preparation, temperature and the surface smoothness determine the floatability and the release rate of microballoons.
 Keywords: Microballoons, Gastro retentive drug delivery system, Hollowspheres, Controlled release
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CHOURASIYA, ANJALI, NARENDRA GEHALOT, and SURESH CHANDRA MAHAJAN. "A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 44–49. http://dx.doi.org/10.24092/crps.2021.110201.
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NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability
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Priya, Agrawal Dilip, and Khandelwal Mohit. "A NOVEL APPROACH IN GASTRO RETENTIVE DRUG DELIVERY SYSTEM: FLOATING DRUG DELIVERY SYSTEM." International Journal of Current Pharmaceutical Review and Research 14, no. 03 (2022): 91–98. https://doi.org/10.5281/zenodo.12658753.
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The purpose of writing this review on gastro retentive drug delivery systems was to compilethe recent literature with special focus on various gastro retentive approaches that haverecently become leading methodologies in the field of site-specific orally administeredcontrolled release drug delivery. In this review, the current technological developments ofFDDS and marketed products have been discussed. In addition, the pharmaceutical basis oftheir design, their advantages and future potential for oral controlled drug delivery arediscussed.
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Kajal D. Chaudhari, Minakshee G. Nimbalwar, Nikita S. Singhal, Wrushali A. Panchale, Jagdish V. Manwar, and Ravindra L. Bakal. "Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system." GSC Advanced Research and Reviews 7, no. 1 (2021): 035–44. http://dx.doi.org/10.30574/gscarr.2021.7.1.0070.
Full textAbstract:
Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.
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Rushikesh Mahale, Rushikesh Mahale, Dr Shivraj Jadhav Dr. Shivraj Jadhav, and Dr Sunil Mahajan Dr. Sunil Mahajan. "Gastro- Retentive floating tablets: A promising strategy for improving dapsone therapeutic efficacy." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 254–70. https://doi.org/10.35629/4494-1003254270.
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This review explores the formulation and development of floating tablets for gastro-retentive drug delivery systems (GRDDS), focusing on their ability to prolong gastric retention and enhance the therapeutic efficacy of drugs with narrow absorption windows. The article discusses key components of floating tablet systems, mechanisms of buoyancy, materials, methods, and evaluation parameters. The significance of such systems for improving therapeutic outcomes and patient compliance is highlighted, along with the limitations and challenges faced in formulation.Dapsone is a widely used antimicrobial agent, suffers from limitations such as poor solubility, short gastric residence time, and variable bioavailability, leading to suboptimal therapeutic outcomes. Gastro-retentive drug delivery systems (GRDDS), particularly floating tablets, offer a promising approach to overcoming these challenges by prolonging gastric retention and enhancing drug absorption. This review explores the formulation strategies, mechanisms, and advantages of gastroretentive floating tablets for Dapsone. Key aspects such as polymer selection, effervescent and noneffervescent floating mechanisms, pharmacokinetic benefits, and in vitro/in vivo evaluation methods are discussed. Additionally, formulation challenges and future prospects, including the potential for advanced polymer technologies and nanocarriers, are highlighted. By improving gastric retention and controlled drug release, floating tablets could significantly enhance the therapeutic efficacy of Dapsone, making them a promising alternative to conventional oral dosage forms.
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S., G. Patil* S. R. Shahi J. J. Dandale R. M. Savakhande. "In-Situ Gel: A Gastro-retentive Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 258–73. https://doi.org/10.5281/zenodo.14603429.
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Conventional oral dosage forms have low bioavailability due to their rapid gastric transition from the stomach, especially for drugs that are less soluble at the alkaline pH of the intestine. Similar to this, medications that have a local effect in the stomach are quickly evacuated and do not have enough time to remain there. To avoid this problem, numerous attempts have been made to prolong the retention duration of the drug delivery method. We will talk about the several methods used to create gastro-retention in drug delivery systems with a focus on the floating in-situ gel system for stomach-specific drug administration. Ionic crosslinking, pH changes, temperature modulation, solvent exchange, and other processes are necessary for the creation of in-situ gels, which allow for the regulated and prolonged release of the medication. The in- situ gelling system uses a variety of polymers, including guar gum, xanthan mucilage, gellan epoxy resin, sodium alginate, pectin, chitosan, sodium citrate, sodium benzoate and polyethylene glycol. The present review briefly addresses the necessity of GRDDS, its pharmaceutical significance, GRDDS methods, variables influencing stomach retention, benefits, drawbacks, Procedure for creating in- situ gelling drug delivery system, the use of polymers in gastro-retentive formulations, assessment of gastro-retentive dosage forms, and comparison of gastro-retentive and conventional drug delivery systems.
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Panda, Satyajit, K. Priyanka, R. Varaprasad, and Snigdha Pattnaik. "Gastroretentive Microspheres: An Innovative Approach for Prolonging Gastric Residence." International Journal of Drug Delivery Technology 9, no. 01 (2019): 01–09. http://dx.doi.org/10.25258/ijddt.9.1.1.
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Gastro-retentive drug delivery systems (GRDDS) like gastro-retentive microspheres have gained immense popularity in the field of oral drug delivery. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, swelling systems, mucoadhesion techniques, floating systems with or without effervescence are being applied to fabricate gastroretentive microspheres. Apart from in-vitro characterization, successful gastro-retentive microspheres development demands well designed in-vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in-vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in-vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in-vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, and variable rate of gastric emptying time are the challenges that limit the availability of gastro-retentive microspheres in the market.
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Chavan, Payal B., Prashant S. Malpure, Gokul S. Talele, and Abhishek R. Kadam. "The Latest Advancements: A Comprehensive Review of Microballoons for Enhanced Gastroretention." Asian Journal of Pharmaceutical Research and Development 12, no. 3 (2024): 222–29. http://dx.doi.org/10.22270/ajprd.v11i3.1425.
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Because of their potential to remain in the gastric region for extended periods of time, gastro-retentive drug delivery methods hold great promise in oral treatment. This improves medication solubility, resulting in increased bioavailability and decreased drug waste. To achieve gastro-retentive qualities, various ways have been proposed, with microballoons in the form of hollow microspheres being a commonly investigated possibility. These microballoons, which are hollow spherical particles with no central core and have a size of less than 200 micrometers, provide an excellent method of managing medication release with site-specific absorption. Floating microballoons release via gastro-retentive mechanisms, effectively increasing bioavailability and providing a viable remedy for stomach retention. Hollow microspheres with optimized properties have the potential to revolutionize new drug delivery, particularly for secure, targeted, and efficient in vivo delivery. They represent a promising approach to gastric retention, reducing variability in plasma drug concentrations. This review provides insights into recent advances in formulation methods, evaluation techniques, the use of polymers in microballoons, and their applications as gastro-retentive drug delivery systems with controlled release capabilities.
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Pakhale, Nilesh V., S. B. Gondkar, and R. B. Saudagar. "Effervescent Floating Drug Delivery System: A review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 836–38. http://dx.doi.org/10.22270/jddt.v9i3-s.2817.
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Effervescent floating drug delivery systems release gas CO2, thus reduce the density of the system and remain buoyant in the stomach 2 for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss in detail about effervescent agent and mechanism of effervescent floating drug delivery system. Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours. This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. At attempt has been made in this review article to introduce the readers to current development in floating drug delivery system, Keywords: Effervescent system, Floating drug delivery system, Effervescent agent, floating lag time, Gastric residence time.
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J.Navya, A.Madhu Babu. "FLOATING MICROSPHERES FOR GASTROINTESTINAL DISORDERS." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 1020–24. https://doi.org/10.5281/zenodo.154529.
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Drug absorption in the gastrointestinal tract is a highly variable process. Floating microspheres are promises to be a potential approach for gastric retention enhances the bioavailability and controlled delivery of various therapeutic agents. Significant attempts have been made worldwide to explore these systems according to patient requirements, both in terms of therapeutic efficacy and compliance. Floating microspheres as gastro retentive dosage forms precisely control the release rate of target drug to a specific site and facilitate an enormous impact on health care. These systems also provide tremendous opportunities in the designing of new controlled and delayed release oral formulations, thus extending the frontier of futuristic pharmaceutical development. Furthermore, recent innovations in pharmaceutical investigation will surely provide real prospects for establishment of novel and effective means in the development of these promising drug delivery systems. Keywords: Gastro Retention, Hollow microspheres, Floating microspheres, Short halflife, Solvent Diffusion, Floating drug delivery system (FDDS).
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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.
Full textAbstract:
Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. The prepared tablets of PCZ were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of PCZ shown that the formulation F9 was found to be the best formulation as it releases 98.89% in a controlled manner for an extended period of time (up to 12 hrs). The release data was fitted to various mathematical models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F9) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months. Prepared floating tablets of PCZ may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.
 Keywords: Prochlorperazine dimaleate, Floating tablet, Gastro retentive, Total floating time.
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Kumari, Reena, Nishant Verma, Nidhi Chaudhary, and Umesh Kumar. "Gastro retentive Ethyl Cellulose Floating Microspheres containing ATENOLOL." International Journal of Advance Research and Innovation 3, no. 2 (2015): 209–19. http://dx.doi.org/10.51976/ijari.321537.
Full textAbstract:
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Incorporation of the drug in a controlled release gastro -retentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current recently developments of Stomach Specific FDDS are discussed that helps to overcome physiological adversities like short gastric residence times and unpredictable gastric emptying times
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Dhanashri, Ghude* Rushikesh Bhanage Dr. Anil Pawar Dr. V. K. Deshmukh. "Floating Tablet A Gastro- Retentive Drug Delivery System: A Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3286–95. https://doi.org/10.5281/zenodo.15465743.
Full textAbstract:
Pharmaceutical research on oral drug delivery, particularly on the gastro-retentive drug delivery system known as the Floating Drug Delivery System (FDDS), has attracted a lot of interest from the pharmaceutical industry. GRDF stands for gastro-retentive dosage forms, which are dosage forms that can be retained in the stomach. With the help of GRDFs, the drug can be released to the upper portion of the GIT more continuously and for a longer period of time. This improves the bioavailability of drugs with limited therapeutic windows, lengthening the time between doses and enhance patient compliance. Drugs with a limited stomach absorption window and local activity are of special interest to FDDS. FDDS has many benefits, particularly for medications with a limited window for absorption in the GIT, main absorption in the stomach, For medications that are least soluble In a high pH environment, prolonged stomach retention increases solubility, decreases drug waste, and increases bioavailability. The goal of this study on floating drug delivery systems (FDDS) was to gather the most recent research on the topic, with an emphasis on the main mechanism of floatation to achieve gastric retention.
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Birajdar, Anuradha A., Madhuri T. Deshmukh, and Rajkumar V. Shete. "A Review on Gastro-Retentive Floating Microspheres." Journal of Drug Delivery and Therapeutics 11, no. 1-s (2021): 131–38. http://dx.doi.org/10.22270/jddt.v11i1-s.4518.
Full textAbstract:
The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application.
 Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods
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Chauhan, Sadanand. "A Review on Gastro-Retentive Drug Delivery System." International Scientific Journal of Engineering and Management 03, no. 03 (2024): 1–9. http://dx.doi.org/10.55041/isjem01416.
Full textAbstract:
The aim of this review is to focus on the various gastro retentive approaches by investigate, compile, and present in most concise way, where the gastroprotective has gained immense popularity in the field of oral drug delivery. In the field of oral drug delivery gastro-retentive drug delivery play an important role. There are various types of GRDDS approaches which can be utilized to retain the dosage form in the stomach and release the drug slowly for an extended period of time. The various GRDDS approaches include high density, low density, mucoadhesive, expandable, magnetic systems and super porous hydrogel system. GRDDS has proved to be effective in both local and systemic actions to treat gastric or duodenal ulcers. Gastro-retentive drug delivery system can be utilized to prolong the residence time of delivery system in the stomach. Where the stomach and duodenum are separated by the pylorus, which has an important role in residence time of the ingested substances in the stomach. GRDDS can be used to overcome challenges related with conventional oral dosage forms. Keywords Gastro-retentive, GRDDS, Oral route, GIT, various approaches, floating system, non-floating system, bio adhesive system.
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Bhuyar, Sajali R., Manjiri M. Auti, Shubhangi A. Bhise, et al. "Innovations and advancements in floating tablet drug delivery systems: a comprehensive review." Pharmacy & Pharmacology International Journal 12, no. 5 (2024): 195–200. https://doi.org/10.15406/ppij.2024.12.00452.
Full textAbstract:
Floating tablets, also known as gastro retentive drug delivery systems (GRDDS), are innovative formulations designed to prolong the retention of drugs in the gastrointestinal tract, particularly the stomach. This approach is highly beneficial for medications with a narrow absorption window in the upper GI tract, requiring extended action or optimal absorption in a specific pH range. The floating mechanism helps improve bioavailability, therapeutic efficacy, and offers controlled drug release, reducing dosage frequency. The formulation of floating tablets typically involves hydrophilic polymers and gas-forming agents like sodium bicarbonate, which ensure buoyancy in gastric fluids. Key preparation techniques include direct compression, wet granulation, and hot melt extrusion. These tablets are advantageous for medications such as furosemide and ofloxacin, which have poor absorption or are extensively metabolized in the first pass. Floating tablets also show potential in enhancing patient compliance, particularly for drugs with short half-lives or those requiring a controlled release. Despite the promising benefits, challenges such as variability in gastric emptying, tablet buoyancy, and large-scale manufacturing complexities exist. Innovations in materials, including biodegradable polymers and 3D printing, aim to address these issues. Market demand for floating tablets is increasing, driven by the rising incidence of chronic diseases, especially in regions like India. In conclusion, floating tablets represent a significant advancement in gastro retentive drug delivery, offering improved therapeutic outcomes for a range of medications, though further research and development are needed to optimize their formulation and production.
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Dharmajit, Pattanayak* Dr. Ramesh Adepu Saumya Das Ramya Sri Sura. "A SYSTEMIC REVIEW ON FLOATING MUCOADHESIVE DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2970–78. https://doi.org/10.5281/zenodo.1231047.
Full textAbstract:
Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity.The floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. Thus, floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. In this regard, this review aims to provide information of different floating and mucoadhesive approaches and their importance. Keywords: Bioadhesive, floating drug delivery, gastroretentive, mucoadhesive
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Aleksovsk, Aleksandar. "FLOATING GASTRO-RETENTIVE DOSAGE FORMS – A NOVEL APPROACH FOR TARGETED AND CONTROLLED DRUG DELIVERY." Journal Human Research in Rehabilitation 2, no. 1 (2012): 23–30. http://dx.doi.org/10.21554/hrr.041201.
Full textAbstract:
Controlled (modified) release dosage forms are one of the key concepts in drug delivery, leading to enhanced drug bioavailability and increased patient’s compliance. However conventional modified release dosage forms encounter one big disadvantage- lack of site-specific drug delivery. Scientists developed different kinds of targeted oral controlled release forms. One of these are gastro-retentive systems- systems which can remain in the stomach region for prolonged period of time and thereby release the active compound in controlled fashion. Floating dosage forms are the most promising approach of all gastro-retentive systems. They are capable to float over the gastric content in longer time intervals. This article makes a review on floating dosage forms in general, different approaches for achieving floatation, advantages and disadvantages of this drug delivery concept. For better understanding the topic,an emphasis is made also on the anatomical and physiological features of the stomach and on the factors affecting gastric retention.
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Subhasish, Saha, P. Sao Anil, Gautam Jagjot, Kumar Roy Vikas, and Paul* Amrit. "ADVANCEMENTS AND CHALLENGES IN GASTRO-RETENTIVE DRUG DELIVERY SYSTEMS." World Journal of Pharmaceutical Science and Research 3, no. 4 (2024): 466–91. https://doi.org/10.5281/zenodo.13626305.
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This article examines the development, operation, applications, and future prospects of gastro-retentive drug delivery systems (GRDDS). GRDDS are designed to prolong the half-life of a drug in the stomach, thereby increasing its bioavailability and therapeutic efficacy, particularly for drugs absorbed in the upper gastrointestinal tract. Among the various GRDDS types whose formulation processes, methods of evaluation, and clinical uses are covered are floating, bioadhesive, swelling, and expandable systems. The review highlights the challenges of developing effective GRDDSs, such as ensuring system biocompatibility and controlling drug release characteristics. Future advancements in GRDDS technology are also being researched in an attempt to improve patient compliance and treatment outcomes.
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Harshdeep, Desai* Tushar Rukari Rashmi Mahabal Dr. Vijay Jagtap. "Beyond Conventional: Recent Advancement on Floating Drug Delivery Systems: An Approach to Oral Controlled and Sustained Drug Delivery Via Gastric Retention." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2971–94. https://doi.org/10.5281/zenodo.14546659.
Full textAbstract:
Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, High-Density Systems, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. highlighting their mechanisms of action and applications in targeted drug delivery. Furthermore, recent innovations in materials science and formulation technologies have enabled the development of novel GRDDS with improved biocompatibility, stability, and controlled release profiles. The review also addresses challenges associated with GRDDS, including physiological variability, drug stability, and regulatory considerations, and proposes potential strategies to overcome these obstacles. Gastro-retentive systems extend the residence time in the stomach, improving drug bioavailability, and ensuring maximum drug concentration at the target site. This review explores different gastro-retentive drug delivery systems, including those made from natural and synthetic polymers, and their applications. It also highlights the factors impacting these systems, as well as the challenges in the process and future prospects for their commercialization Additionally, the clinical relevance of GRDDS in the treatment of various gastrointestinal disorders and their future prospects in personalized medicine and targeted therapy are explored.
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Venkateswara Rao, Korlapati, and V. V. Venkatachalam. "Recent Advances in Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 3 (2016): 3221–54. http://dx.doi.org/10.37285/ijpsn.2016.9.3.1.
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Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, muco-adhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive drug delivery systems. Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by a narrow absorption window. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. So, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and required benefits to patients. The purpose of writing the article was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In particular, bioadhesive, size-increasing and floating drug delivery systems are presented and their major advantages and shortcomings are critically discussed in this review. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients
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SAINI, SHANTI, RAJESH ASIJA, and ANIL GOYAL. "FLOATING MICROSPHERE AS GASTRO RETENTIVE DRUG DELIVERY SYSTEM: AN UPDATED REVIEW." Tropical Journal of Pharmaceutical and Life Sciences 9, no. 2 (2022): 21–29. https://doi.org/10.61280/tjpls.v9i2.80.
Full textAbstract:
Floating drug delivery system is anticipated to float in long lasting way when come in contact with the gastric contents and subsequently to improve the drugs bioavailability. The different floating formulations which include powders, tablets, pills, capsules, granules and films are presently under research and development. Floating microspheres (FMs) are particularly getting importance because of their varied applicability for drug targeting to stomach. These gastro retentive FMs are systems having less density have the potential to float and distributed evenly through the entire gastric fluid, lessen the chances of gastric emptying and ensure the drug release for longer period of time. The FMs also enhances the patient compliance by diminishing the frequency of dosage. By employing FMs, significant therapeutic effect could be attained from drugs having short half-life. In this review we will discuss fundamentals of floating microspheres along with recent applications of floating microspheres.
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Addanki Anusha, Krishnaphanisri Ponnekanti, Dumpala Sangeetha, Vaishnavi Ekamamidi, and Lokesh Dharavath. "Brief overview of gastro-retentive drug delivery system." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 056–62. https://doi.org/10.30574/wjbphs.2025.21.2.0128.
Full textAbstract:
English oral delivery of drugs was the most commonly used modality because of patient compliance and ease of administration. After oral administration of any drug, its bioavailability is affected by its residence time in the stomach. This variability may lead to unpredictable times when achieving peak plasma levels. The purpose of writing this review on gastro-retentive drug delivery systems was to comply with the recently become leading methodologies in site-specified orally administrated controlled releasing drug delivery. GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period before it reaches its absorption site. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, and floating system with or without effervescence are being applied to fabricate GRDDS. Recently applied gastrointestinal technologies such as expandable, super porous hydrogel; bio\mucoadhesive, magnetic, ion-exchange resins; and low- high-density systems have also been examined along their merits and demerits. The purpose of factors related to GRDDS, its advantages and disadvantages, and emphasis is given on its significance over conventional forms of drug deliveries. The classification, formulation, objectives, methods, and results consideration for gastro retention drug delivery system.
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Hafeez, Abdul, Arun Maurya, Jagpal Singh, Ankit Mittal, and Lakhan Rana. "An overview on floating microsphere: Gastro Retention Floating drug delivery system (FDDS)." Journal of Phytopharmacology 2, no. 1-3 (2013): 1–12. http://dx.doi.org/10.31254/phyto.2013.21310.
Full textAbstract:
Drug absorption in the gastrointestinal tract is a highly variable process. Floating microspheres are promises to be a potential approach for gastric retention enhances the bioavailability and controlled delivery of various therapeutic agents. Significant attempts have been made worldwide to explore these systems according to patient requirements, both in terms of therapeutic efficacy and compliance. Floating microspheres as gastro retentive dosage forms precisely control the release rate of target drug to a specific site and facilitate an enormous impact on health care. These systems also provide tremendous opportunities in the designing of new controlled and delayed release oral formulations, thus extending the frontier of futuristic pharmaceutical development. Furthermore, recent innovations in pharmaceutical investigation will surely provide real prospects for establishment of novel and effective means in the development of these promising drug delivery systems.
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Navneet, Kumar Verma. "Introduction and Application of Bilayer Floating Tablet: A Brief Review." International Journal of Medical and Pharmaceutical Research 2, no. 2 (2023): 37–45. https://doi.org/10.5281/zenodo.8151947.
Full textAbstract:
Bilayer tablet is an innovation period for the successful advancement of controlled release formulation as well as a variety of features to produce a successful drug delivery system technique. Controlled release dose forms have been widely employed to improve treatment with a number of key medications. Inclusion of drugs in controlled release gastro-retentive dosage forms that can remain in the gastric region for several hours would significantly increase drug bioavailability, reduce drug waste, and improve the solubility of drugs that are less soluble in high pH environments. Floating drug delivery systems, swelling and expanding systems, polymeric bio adhesive systems, high-density systems, changed form systems, and other postponed gastric systems are now used in the extension of Gastric Retention Time.
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Patil, Nilesh Sureshrao, and Kishor Salunkhe. "FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ATORVASTATIN USING STATISTICAL DESIGN (JMP SOFTWARE)." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 19–25. http://dx.doi.org/10.22270/jddt.v9i4-a.3284.
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More complications and cost of promoting of imaginative drugs are more prominent consideration to the improvement of controlled release (CR) drug delivery systems. Sustained release or controlled release drug delivery system helps to reduced toxicity of drug and more patient compliant drug delivery system. The aim of this study is to have efficient means of manufacturirng of Gastro retentive floating tablet of Atorvastatin Calcium. Atorvastatin is used in the treatment of hyperlipidaemia. Oral bioavailability of atorvastatin calcium is less than 12% due to instability and in complete absorption. It also undergoes high first pass metabolism. It is absorbed more in the upper part of the GIT. Gastro retentive drug delivery system of Atorvastatin enhanced the bioavailability by retaining the drug in upper part of GIT and by preventing the first pass metabolism of the drug. The objective of present work was to create and assessed oral extended release gastro retentive tablet dosage form of Atorvastatin by using direct compression method using Methocel K4MDC2, Methocel K100MDC2 and Glyceryl behenate using Statistical design (JMP software). Sodium bicarbonate and Citric Acid is used as gas generating agent which helps to float the tablet.
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Ramarao, Ch Taraka, J. Vijaya Ratna, and R. B. Srinivasa. "DESIGN AND CHARACTERIZATION OF ALFUZOSIN HCL GASTRORETENTIVE FLOATING MATRIX TABLETS EMPLOYING HPMC K 100M." INDIAN DRUGS 55, no. 11 (2018): 71–73. http://dx.doi.org/10.53879/id.55.11.10741.
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The present investigation involves developing gastro retentive drug delivery systems (GFDDS) of alfuzosin HCl using HPMCK100M a is the matrixing agent and floating enhancer. Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and thereby increase the oral bioavailability. From the drug release study, it was concluded that the AFTB4 formula of HPMC K 100 M matrix tablets gives the controlled release up to 12 hours by showing increased release with floating lag time 24 seconds. Non – Fickian diffusion was the drug release mechanism from the matrix tablets formulated employing HPMC K 100 M. The matrix tablets (AFTB4) formulated employing 40 % HPMC K 100 M are best suited to be used for gastro retentive dosage form of alfuzosin HCl. Finally, it can be concluded that good candidates for the preparation of gastro retentive dosage forms due its gastric stability, gastric absorption and better bioavailability.
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Janhavi, Zope S., Sonawane L. Pradnya, A. B. Darekar, and R. B. Saudagar. "A Comprehensive Review on Gastro-Retentive Floating Drug Delivery Systems." Asian Journal of Pharmaceutical Research 5, no. 4 (2015): 211. http://dx.doi.org/10.5958/2231-5691.2015.00033.7.
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Durga Srinivasarao M, Saravanakumar K. та Chandra Sekhar Kothapalli Bannoth. "Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems". International Journal of Research in Pharmaceutical Sciences 12, № 2 (2021): 1330–37. http://dx.doi.org/10.26452/ijrps.v12i2.4684.
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Gastro-retentive drug delivery systems (GRDDS) attributes to gastric maintenance time combined with the medication discharge for expanded time has essentially improved patient consistency. Medications for which the chief fundamental site of ingestion is the stomach or the proximal piece of the small digestive tract or have the assimilation issue in the distal piece of the digestive system are reasonable for GRDDS. Orally sustaining or controlling the drug release combined with gastric retention property can avoid recurrent dosing in the case of drugs with short half-lives. GRDDS is also effective in locally treating gastric and duodenal ulcers, including oesophagitis and Helicobacter pylori infections. In this current survey, the physiology of the stomach alongside its motility design, typically called migrating motor complex (MMC), was discussed. Various approaches to GRDDS with a focus on floating drug delivery systems (FDDS) were reviewed. The vacillations in plasma drug focus are limited and portion subordinate unfriendly impacts can be forestalled by FDDS, particularly for the medications with a restricted restorative list. Slow arrival of the medication into the body by means of FDDS limits the counter movement prompting higher medication proficiency. Further, the Advantages, limitations, suitable drug candidates, factors affecting and Future challenges of FDDS were discussed.
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Vinod, Kumar, Somkuwar Sushma, and Kumar Singhai Akhlesh. "A recent update on gastro retentive drug delivery systems." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 125–44. https://doi.org/10.5281/zenodo.11960559.
Full textAbstract:
Gastro retentive drug delivery systems (GRDDS) have garnered significant attention in recent years due to their potential to enhance therapeutic efficacy and patient compliance by prolonging gastric residence time and optimizing drug release kinetics. This review provides a comprehensive overview of the latest advancements in GRDDS, focusing on formulation strategies, design principles, and evaluation methodologies. Various approaches such as floating systems, mucoadhesive systems, expandable systems, and magnetic systems are discussed in detail, highlighting their mechanisms of action and applications in targeted drug delivery. Furthermore, recent innovations in materials science and formulation technologies have enabled the development of novel GRDDS with improved biocompatibility, stability, and controlled release profiles. The review also addresses challenges associated with GRDDS, including physiological variability, drug stability, and regulatory considerations, and proposes potential strategies to overcome these obstacles. Additionally, the clinical relevance of GRDDS in the treatment of various gastrointestinal disorders and their future prospects in personalized medicine and targeted therapy are explored. Overall, this review aims to provide valuable insights into the current state-of-the-art in GRDDS research and its implications for the advancement of drug delivery science.
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DA, Bansode. "Advances in the Preparation Techniques of Floating Microspheres with Exploration of AI Tool in Product Development." Pharmaceutical Drug Regulatory Affairs Journal 6, no. 1 (2023): 1–17. http://dx.doi.org/10.23880/pdraj-16000146.
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This review paper focuses on recent developments in gastroretentive drug delivery systems for controlled release oral drug administration. Gastric emptying’s variability presents challenges to drug delivery systems, making gastroretentive drug delivery systems increasingly popular for retaining drugs in the stomach and ensuring gradual release. Traditional oral delivery systems often fail to overcome gastrointestinal obstacles, resulting in incomplete drug release, decreased efficacy. Thus, achieving prolonged gastric residence times is crucial, particularly for drugs with upper small intestine absorption windows. Gastro retentive drug delivery system provide for prolonged drug release in the upper digestive system, improving bioavailability for drugs with narrow therapeutic windows, extending dosing intervals, and enhancing patient compliance. The purpose of this review is to discuss recent advancements in the preparation techniques for floating drug delivery systems and highlights the incorporation of AI-Enabled design and optimization in drug release behavior. These technologies enhance precision and efficiency in gastroretentive drug delivery systems development, promising further improvements in drug delivery effectiveness and patient adherence.
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Deshmukh, Aishwarya V., Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." Der Pharma Chemica 15, no. 6 (2023): 4. https://doi.org/10.5281/zenodo.13353444.
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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time, content uniformity and in vitro drug release.
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Aishwarya, V. Deshmukh, Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." DER PHARMA CHEMICA 15, no. 6 (2023): 4. https://doi.org/10.4172/0975-413X.15.6.142-146.
Full textAbstract:
Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time, content uniformity and in vitro drug release.
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*Shashikant, D. Modekar, T. Karpe Sujit, R. Kudale Krishna, et al. "A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY: STRATEGIES FOR PROLONGED GASTRIC RETENTION." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 1161–76. https://doi.org/10.5281/zenodo.15497951.
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The potential of gastro retentive drug delivery systems (GRDDS) to improve patient compliance and therapeutic efficacy by extending stomach residence time and improving drug release kinetics has attracted much attention recently. This review offers a thorough summary of the most recent developments in GRDDS, emphasizing formulation tactics, design tenets, and assessment techniques. A detailed discussion of several strategies is given, emphasizing their modes of action and uses in targeted drug delivery, including floating, Mucoadhesive, expandable, and magnetic systems. Furthermore, new GRDDS with enhanced stability, controlled release profiles, and biocompatibility have been made possible by recent advancements in formulation technologies and materials science. The paper also discusses the difficulties that come with GRDDS, such as medication stability, physiological variability, and regulatory issues, and suggests possible solutions. Furthermore, the clinical applicability of GRDDS in the management of different gastrointestinal conditions and their potential use in targeted therapy and personalized medicine will be examined. The overall goal of this study is to offer insightful information on the state-of-the-art in GRDDS research at the moment and how it relates to the development of drug delivery technology.
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Kam, Li-Ying, Jia-Woei Wong, and Kah-Hay Yuen. "In Vivo Evaluation of Thiamine Hydrochloride with Gastro-Retentive Drug Delivery in Healthy Human Volunteers Using Gamma Scintigraphy." Pharmaceutics 15, no. 2 (2023): 691. http://dx.doi.org/10.3390/pharmaceutics15020691.
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A floating tablet system containing thiamine hydrochloride, a model drug with a narrow absorption window, was evaluated. The tablet was found to have a floating lag time of less than 30 s with a sustained drug release over 12 h during in vitro dissolution studies. The gastro-retentive property of the tablet in relation to the bioavailability of thiamine was determined in healthy human volunteers using gamma scintigraphy under fasted and fed conditions. The gastro-retentive time of the floating tablet could be prolonged up to 10 h under the fed state, compared to about 1.8 h in the fasted state. The prolonged gastric retention under the fed state resulted in a 2.8-fold increase in oral bioavailability of thiamine compared to that of the fasted state. There was also a 1.4-fold increase in thiamine absorption compared to that of a conventional immediate release tablet in the fed state. In the fasted state, the extent of thiamine absorption from the floating tablet was only about 70% of that absorbed from the immediate release tablet. Thus, to achieve a better performance, such floating tablet systems should be administered under a fed condition, to prolong the gastric retention time.
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Toushiba, J. Khan*¹ Asra S. Shaikh² Zoya F. Shaikh³ Mohammad Jawwad⁴ Amreen Tabassum⁵ Sheikh Samir Md. Mustafa⁶ Ravi Kalsait⁷ Tina K. Ramchandani8. "Formulation And Evaluation Of Gastroretentive Floating Tablet Of Atorvastatin Calcium As A Model Drug: A Review." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 323–29. https://doi.org/10.5281/zenodo.10653282.
Full textAbstract:
Oral solid dosage forms are the preferred administration route for many drugs, especially for modified release products. However, for optimal therapeutic effect, the drug must be well absorbed throughout the gastrointestinal tract (GIT). Challenges arise when drugs have a narrow absorption window in the GIT or when they are unstable in GI fluids. Developing oral controlled release dosage forms becomes crucial not only to prolong drug delivery but also to enhance retention within the stomach or small intestine until complete drug release occurs. Gastro Retentive Drug Delivery Systems (GRDDS) offer a promising approach to address these challenges, particularly for drugs like Atorvastatin calcium, which undergo rapid clearance in the intestine. Successful formulation of a Gastro Retentive Drug Delivery System for Atorvastatin calcium was achieved using direct compression technique, employing different viscosity grades of Hydroxypropyl methylcellulose (HPMC) as binder, Avicel PH102 as diluent, sodium bicarbonate as a gas generating agent, talc as a glidant, and magnesium stearate as a lubricant. The optimized tablet formulation demonstrated 99.74% drug release over 24 hours, with sustained release characteristics and buoyancy throughout the study duration. Among the various HPMC grades tested, HPMC K100M exhibited the most significant retardation in drug release. The in vitro dissolution profile followed zero-order kinetics, indicating a controlled release mechanism.