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Journal articles on the topic 'Gastrointestinal ulcer'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Liu, Yifei. "Clinical Effect of Omeprazole Combined with Amoxicillin in the Treatment of Gastric Ulcer." Proceedings of Anticancer Research 7, no. 5 (2023): 1–6. http://dx.doi.org/10.26689/par.v7i5.5300.

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Objective: To investigate the therapeutic effect of omeprazole + amoxicillin in patients with gastric ulcers. Methods: 62 cases of patients with gastric ulcers who were treated from January 2022 to December 2022 were recruited and randomly divided into groups. Omeprazole + amoxicillin treatment was included in the study group, and amoxicillin treatment was included in the control group. The score of gastric ulcer symptoms, time of symptom resolution, gastrointestinal hormone index, and adverse reactions were compared. Results: The gastric ulcer symptom scores in the study group were lower than

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Zhou, Xiaomin, Songze Ding, and Ruobing Hu. "The Related Study on the Pathogenesis of Gastrointestinal Diseases in Gastrointestinal Flora and the Risk of Gastric Ulcer Carcinogenesis." Journal of Biomaterials and Tissue Engineering 11, no. 7 (2021): 1418–28. http://dx.doi.org/10.1166/jbt.2021.2755.

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Gastrointestinal diseases are common diseases of many kinds. The pathogenesis of gastrointestinal disease has not been fully understood. In this study with gastric mucosa specimen, among the three groups of chronic gastritis, gastric ulcer, and duodenal ulcer, there were differences of Helicobacter pylori (H. pylori), Lactobacillus, Prevotella, Clostridium, B. fragilis, and Enterobacteriaceae. There was no significant difference in Lactobacillus among chronic gastritis, gastric ulcers, and duodenal ulcers with fecal specimens, but there was a significant difference between these three groups a

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Guo, Kuanpeng, Zhengqiu Li, Bibo Qiu, Bin Hu, and Suwu Yi. "Analysis of Gastric Diseases and Their Symptoms Based on Indexes of Pepsinogen I (PGI) and Pepsinogen II (PGII): Take 1106 Patients as Samples." Cellular Microbiology 2022 (May 17, 2022): 1–6. http://dx.doi.org/10.1155/2022/8393351.

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In this study, preoperative analysis of 1106 gastropathy patients with abdominal pain, vomiting, dyspepsia, and other symptoms was conducted. Independent sample t -test and correlation analysis and other ways were used for data cleansing and analysis. Findings were as follows: (1) Samples of different genders showed significance in PGI and PGII. The PGI and PGII values of women were significantly lower than those of men. (2) Age showed a significant positive correlation with PGI and PGII, which indicates that as the age increases, the PGI and PGII values become higher. (3) There was a signific

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Wei, Hualin, Wei Han, Xianbo Zhang, and Ming Zhang. "Gastroscopic observation and dose-volume histogram parameter study on gastrointestinal mucous injury for pancreatic cancer treated with TOMO." Medicine 103, no. 25 (2024): e38469. http://dx.doi.org/10.1097/md.0000000000038469.

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To explore the relationships between gastrointestinal radiation injuries of pancreatic cancer patients treated with TOMO and dose-volume histogram parameters prospectively. Seventy patients with pancreatic cancer who underwent TOMO were enrolled in this prospective study from February 2015 to May 2020. The clinical and dose-volume histogram parameters of the patients were collected. The optimal dose parameters for gastrointestinal radiation ulcers were confirmed based on the receiver operating characteristic curve (ROC) and the area below the ROC curve. Acute gastrointestinal tract toxic and s

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Le, Quoc Anh, and Ngoc Le Nguyen. "Study on the relationship between traditional medicine syndromes in patients with peptic ulcer disease and peptic ulcer disease complicated by gastrointestinal hemorrhage." Tạp chí Y Dược Huế 15, no. 2 (2025): 44–50. https://doi.org/10.34071/jmp.2025.2.6.

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Background: Peptic ulcer disease is quite common in the community, prone to recurrence, and associated with many dangerous complications, including gastrointestinal bleeding. According to traditional medicine, described in peptic ulcer disease belong to the category of “gastric upset”. To assist physicians in diagnosing and effectively treating this disease, while also reducing the risk of gastrointestinal bleeding, we conducted this study. Objectives: To investigate certain characteristics of traditional medicine syndromes and patterns in patients with peptic ulcer disease and those with pept

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Zhang, Wenji, Yingyi Lian, Qiuhua Li, et al. "Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers." Molecules 25, no. 20 (2020): 4626. http://dx.doi.org/10.3390/molecules25204626.

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Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the

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Basak, Shiplu, Muhammad Sayedul Arefin, Rashedul Islam, Azam Jahangir, and Md Razibul Alam. "Aetiology and Pattern of Presentation of Upper Gastrointestinal Tract Ulcers among Patients Attending the Gastroenterology Department of BSMMU-A Tertiary Level Hospital." Scholars Journal of Applied Medical Sciences 11, no. 1 (2023): 204–13. http://dx.doi.org/10.36347/sjams.2023.v11i01.032.

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Background: Upper gastrointestinal endoscopy is the most common procedure performed in Gastroenterology department for numerous indications and ulceration of the upper GI tract is one of the major pathological findings during endoscopy. Early diagnosis of upper GI ulcers with definite cause is the mainstay of therapy for patient’s cure and prevention of complications. Different clinical features are observed in different types of ulcer. Objective: The objective of this study is to find out the causes of different types of ulceration in the upper gastrointestinal tract along with their clinical

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Dr., Syed Muhammad Adeel Sikandar Dr. Muhammad Waqas Dr. Rabbia Aslam. "LACK OF AWARENESS OF SELF-MEDICATION LEADING TO GASTROINTESTINAL ULCERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 16805–11. https://doi.org/10.5281/zenodo.2525788.

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<em>This paper covers the part of presentation of gastrointestinal ulcers alongside its beginning because of self-medicine and causative medications. The occurrences of gastrointestinal ulcers are straightforwardly extent to the rate of utilization of self-drug particularly of NSAIDs for relief from discomfort purposes. The pervasiveness of self-prescription and its terrible results is normal issue in creating nations. The gastrointestinal ulcers incorporate stomach, esophageal and small intestinal ulcers. There are a few causative specialists of gastrointestinal ulceration that incorporates a

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9

Singh, Karanvir, Rajesh Kumar, Ajeet Pal Singh, Meenakshi Malhotra, Amar Pal Singh, and Ritu Rani. "Peptic Ulcer: A review." International Journal of Medical, Pharmacy and Drug Research 8, no. 2 (2024): 38–46. http://dx.doi.org/10.22161/ijmpd.8.2.5.

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Peptic ulcers, characterized by painful sores that develop on the lining of the stomach, small intestine, or esophagus, are a prevalent gastrointestinal condition affecting millions worldwide. This abstract provides an overview of the causes, symptoms, and treatment options for peptic ulcers. Peptic ulcers primarily stem from the imbalance between aggressive factors such as gastric acid secretion, pepsin, and Helicobacter pylori infection, and defensive mechanisms like mucosal barrier integrity and blood flow. Lifestyle factors such as excessive alcohol consumption, smoking, and stress, along

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KHAN, SU, S. REHMAN, F. WAHAB, et al. "FREQUENCY OF PEPTIC ULCER DISEASE IN PATIENTS WITH LIVER CIRRHOSIS PRESENTING WITH UPPER GASTROINTESTINAL BLEED." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1441. https://doi.org/10.54112/bcsrj.v2024i1.1441.

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Peptic ulcer disease (PUD) is a notable cause of upper gastrointestinal bleeding (UGIB), especially in patients with liver cirrhosis, complicating their clinical outcomes. Understanding its prevalence and characteristics in this population is vital for effective management. Objective: To determine the frequency of peptic ulcer disease in patients with liver cirrhosis presenting with upper gastrointestinal bleeding (UGIB). Methods: This descriptive cross-sectional study was conducted in the Department of Gastroenterology at Hayatabad Medical Complex, Peshawar, over a six-month period. A sample

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Ali, Md Zulfikar. "Peptic ulcer disease." KYAMC Journal 3, no. 2 (2013): 270–72. http://dx.doi.org/10.3329/kyamcj.v3i2.15164.

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A peptic ulcer, also known as peptic ulcer disease (PUD) is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm. As many as 70%-90% of such ulcers are associated with Helicobacter pylori, a spiral-shaped bacterium that lives in the acidic environment of the stomach. KYAMC Journal Vol. 3, No.-2, January 2013, Page 270-272 DOI: http://dx.doi.org/10.3329/kyamcj.v3i2.15164

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KHAN, HAMZULLAH. "GASTROINTESTINAL DISEASES;." Professional Medical Journal 15, no. 04 (2008): 459–64. http://dx.doi.org/10.29309/tpmj/2008.15.04.2856.

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. Objectives: To determine the frequency of gastrointestinal (GI) diseases/symptoms in a tertiary care hospital of Peshawar.Methods: A Cross sectional observational study was conducted in Medical department Khyber teaching hospital Peshawar from August 2005to march 2006. A total of 189 patients with established diagnosis of any gastrointestinal disease were randomly selected. Out of total101(53.43%) were males and 88(46.56%) were females. Relevant information’s were recorded on a pre-designed questionnaire was designedin accordance with the objectives of the study. Results: The age range of th

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Vare, Vijay A., Tushar R. Bagle, and Rohankumar C. Hire. "Evaluation of antiulcer activity of diltiazem in rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 38. http://dx.doi.org/10.18203/2319-2003.ijbcp20175548.

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Background: The risk factors for patients with cardiovascular diseases and gastrointestinal diseases overlap. Majority of the patients have both problems coexistent. Thus, there is need of medicine that can be used for both the diseases.Methods: Rats weighing 150-250gm of either gender were procured for the study from central animal house. The animals were divided into 7 groups. Control group (Distilled water 2ml), diclofenac sodium (12mg/kg), diltiazem (10mg/kg), diltiazem (30mg/kg), diltiazem (60mg/kg), ranitidine (8mg/kg), ranitidine (16mg/kg). After six hours, scarification of animals was

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Tomita, Toshihiko, Sumire Mori, Katsuyuki Tozawa, et al. "Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?" Gastroenterology Research and Practice 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/4653250.

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Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between N

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Włodarczyk, A. W., J. J. J. Zawadzki, A. G. G. Gajda, P. Ł. Kamiński, L. Lembas, and K. Bielecki. "Endoscopic Obliteration for Bleeding Peptic Ulcer." Diagnostic and Therapeutic Endoscopy 4, no. 2 (1997): 61–64. http://dx.doi.org/10.1155/dte.4.61.

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A group of 133 patients treated for bleeding peptic ulcer in our Department, is reviewed. Within several hours of admission, all patients underwent upper gastrointestinal tract gastroscopy and obliteration of the bleeding ulcer. Bleeding gastric ulcers were found in 41 patients, and duodenal ulcers in 92 patients. Patients were classified according to the Forrest scale: IA – 11 patients, IB – 49 patients, IIA – 35 patients, lIB – 40 patients. In 126 (94.7%) patients the bleeding was stopped, and 7 required urgent surgery: 3 patients with gastric ulcer underwent gastrectomy, and 4 with duodenal

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Mordvin, Pavel A., Mikhail Yu Kozlov, Yuri Yu Sokolov, et al. "Treatment of a Cushing's ulcer in a 7-y.o. child after a tumor (medulloblastoma) removal in ventricle IV." Russian Journal of Pediatric Surgery 28, no. 1 (2024): 82–89. http://dx.doi.org/10.17816/ps672.

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BACKGROUND: Cushing's ulcer is a stress ulcer in the stomach or duodenum which basic etiological factor is increased intracranial pressure. The increased intracranial pressure is caused, most often, by intracranial neoplasms, cranial-cerebral injury or previous neurosurgical interventions. Cushing's ulcers are usually solitary and deep, often complicated with recurrent gastrointestinal bleedings and less often with perforations. In cases of suspected perforation in a complex anatomical localization (posterior wall of the duodenum), the method of choice according to the world literature is comp

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Miller, Mark J. S., Wallace K. MacNaughton, Xiao-Jing Zhang, et al. "Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 1 (2000): G192—G200. http://dx.doi.org/10.1152/ajpgi.2000.279.1.g192.

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Sangre de grado is an Amazonian herbal medicine used to facilitate the healing of gastric ulcers and to treat gastritis, diarrhea, skin lesions, and insect stings. This study was designed to evaluate the gastrointestinal applications. Gastric ulcers were induced in rats by brief serosal exposure of the fundus to acetic acid (80%). Sangre de grado was administered in drinking water at 1:1,000 and 1:10,000 dilutions from the postoperative period to day 7. Guinea pig ileum secretory responses to capsaicin, electrical field stimulation, and the neurokinin-1 (NK-1) agonist [Sar9,Met(O2)11]substance

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18

Ruuska, T., P. Vaajalahti, P. Arajärvi, and M. Mäki. "Prospective Evaluation of Upper Gastrointestinal Mucosal Lesions in Children with Ulcerative Colitis and Crohn's Disease." Journal of Pediatric Gastroenterology and Nutrition 19, no. 2 (1994): 181–86. http://dx.doi.org/10.1002/j.1536-4801.1994.tb11273.x.

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SummaryEighty‐eight consecutive children with inflammatory bowel disease were studied, and upper gastrointestinal endoscopy was performed in 80 of them as one of the initial investigations before commencing medical or nutritional treatment. Forty‐one children were found to have Crohn's disease and 47, ulcerative colitis. Upper gastrointestinal endoscopy revealed pathology in 32 (80%) cases of Crohn's disease, esophagitis in 16, and esophageal ulcer in two, nonspecific gastritis in 22, duodenitis or duodenal ulcer in 18, and Helicobacter pylori infection in two cases. Granulomas were detected i

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Kim, Young Hak, Katsuhiro Masago, and Michiaki Mishima. "Erlotinib and Gastrointestinal Ulcer." Journal of Thoracic Oncology 5, no. 7 (2010): 1108–9. http://dx.doi.org/10.1097/jto.0b013e3181e07f29.

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Correlation of endoscopic findings with clinical diagnosis in patients with upper abdominal pain." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 2 (2024): 100–115. https://doi.org/10.5281/zenodo.15378661.

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<strong>Abstract</strong> Abdominal pain is a frequent presentation to general practice. Evaluation of patient with upper abdominal pain requires a thorough understanding of the anatomy and physiology of upper gastrointestinal system and adjacent organ systems, and an understanding of diseases that may present with upper abdominal pain. A systematic approach to the evaluation of abdominal pain is essential for the appropriate care of patients. Upper gastrointestinal tract disorders are one of the most common disorders encountered in surgical OPD causing Upper GI Pain. The common symptoms being

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Rahatullah, Haidari Said. "PREVALENCE AND ASSOCIATED FACTORS OF PEPTIC ULCER DISEASE AMONG DYSPEPTIC PATIENTS AT ENDOSCOPY UNIT IN KABUL, AFGHANISTAN." Journal of Applied Pharmaceutical Sciences and Research 6, no. 2 (2023): 19–24. http://dx.doi.org/10.31069/japsr.v6i2.04.

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Introduction: Dyspepsia is a medical term utilized to describe a cluster of symptoms related to the digestive system, particularly in the upper gastrointestinal tract. The most prevalent causes of dyspepsia encompass gastro esophageal reflux disease (GERD), peptic ulcer disease (PUD), and non-ulcer dyspepsia (NUD). A peptic ulcer is a sore or erosion that forms in the lining of the stomach, upper part of the small intestine, or lower part esophagus. Materials and Methods: The study incorporated 500 dyspeptic patients who underwent upper gastrointestinal endoscopic assessments. This hospi

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Tundis, Rosa, Monica R. Loizzo, Marco Bonesi, et al. "Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301234.

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Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus b

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Faisal, William, and Luciana Rotty. "Upper Gastrointestinal Bleeding in Critically Ill Patient: Literature Review." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 22, no. 3 (2022): 226–33. http://dx.doi.org/10.24871/2232021226-233.

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Critically ill patients are at risk for stress ulcers in the upper digestive tract. Various risk factors have been associated with this condition. Patients who are critically ill are at risk of bleeding due to stress related mucosal disease (SRMD). Upper gastrointestinal tract problems usually occur as a result of severe physiological stress. Patients may develop gastric erosion and develop stress ulcers with severe gastrointestinal bleeding which can be fatal. Routine pharmacological use of stress ulcer prophylaxis (SUP) does not reduce overall mortality in intensive care patients. This incre

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Pathak, Karishma. "A Review on Incidence of Gastric Ulcer and its Herbal Remedies." Journal of Drug Discovery and Development 5, no. 1 (2022): 22–24. http://dx.doi.org/10.24321/2581.6861.202104.

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Gastric ulcer is basically an inflamed break in the mucus lining membrane on the gastrointestinal alimentary track. The most common causes of gastric ulcers include H. pylori and gastric prostaglandin loss associated with the use of NSAIDs medication. Gastric ulcer formation depends on the presence of pepsin and acid secretions in gastric juice which breakdown the mucosal defences. It may be caused due to excessive stress or irregular food habits. Many synthetic drugs are used for the treatment of ulcer but they may have certain side effects. On the other hand, herbal medicines are completely

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Zhang, Yu-Hua, Zhi-Hua Xu, Shuang-Shuang Ni, and Hong-Xia Luo. "Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children." World Journal of Gastroenterology 30, no. 7 (2024): 705–13. http://dx.doi.org/10.3748/wjg.v30.i7.705.

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BACKGROUND The detection rate of peptic ulcer in children is improving, with development of diagnostic procedures. Gastroscopy is the gold standard for the diagnosis of peptic ulcer, but it is an invasive procedure. Gastrointestinal contrast-enhanced ultrasonography (CEUS) has the advantages of being painless, noninvasive, nonradioactive, easy to use, and safe. AIM To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in children. METHODS We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June 2022. All children were e

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RaviKKumar, V. R., Sanjesh Rathi, Shubham Singh, et al. "A Comprehensive Review on Ulcer and Their Treatment." Chinese Journal of Applied Physiology 39 (2023): e20230006. http://dx.doi.org/10.62958/j.cjap.2023.006.

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A peptic ulcer is a lesion (sore) on the stomach lining, or duodenum. Peptic ulcers are probably a twentieth-century condition. The ulcer disease continues to be a significant source of worldwide morbidity and mortality. The Gastrointestinal ulcers and duodenal ulcers are considered the two most extreme types of peptic ulcers. Peptic ulcers are found to be caused by an excess of violent factors including Hydrochloric acid (HCL) pepsin, refluxed bile leukotrienes (LT), reactive oxygen species (ROS) and protective factors, these include mucus-bicarbonate barrier functions, prostaglandins (PGs),

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Singh, R., R. Trickett, CER Meyer, S. Lewthwaite, and D. Ford. "Prophylactic proton pump inhibitors in femoral neck fracture patients – A life - and cost-saving intervention." Annals of The Royal College of Surgeons of England 98, no. 6 (2016): 371–75. http://dx.doi.org/10.1308/rcsann.2016.0106.

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Introduction Acute gastrointestinal stress ulceration is a common and serious complication of trauma. Prophylactic proton pump inhibitors (PPIs) or histamine receptor antagonists have been used in poly-trauma, burns and head and spinal injuries, as well as on intensive care units, for the prevention of acute gastric stress ulcers. Methods We prospectively studied the use of prophylactic PPIs in with femoral neck fracture patients, gathering data on all acute gastric ulcer complications, including coffee-ground vomiting, malena and haematemesis. We then implemented a treatment protocol in which

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Kartheek, Chegu* Innaiah Nallaboina Divya Billi Ajay Babu Palaparthi. "A REVIEW ON SOME HOME REMEDIES ACT AS GASRTOPROTECTIVE ACTIVITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4640–43. https://doi.org/10.5281/zenodo.2581500.

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<em>Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract.</em><em> Peptic ulcers include Gastric ulcers that occur on the inside of the stomach and duodenal ulcers that occur on the inside of the upper portion of your small intestine (duodenum). The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of aspirin and certain other painkillers, such as ibuprofen and naproxen sodium. The most common pept

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ASTHA, SACHDEVA, KUMAR MOHANTY PRADEEP, and KUMAR SHARMA VIRENDRA. ""Evaluation of anti-ulcer activity of sphagenticola trilobata plant extract in alcohol induced gastric ulcer in rats"." International Journal of Multidisciplinary Research and Studies 07, no. 06 (2024): 53–62. https://doi.org/10.5281/zenodo.11652243.

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The present study investigates the anti-ulcer activity of <em>Sphagneticola trilobata </em>plant extract in an alcohol-induced gastric ulcer model in rats. Gastric ulcers, a common gastrointestinal disorder, are often exacerbated by alcohol consumption. This research aims to evaluate the protective effects and potential mechanisms of <em>Sphagneticola trilobata</em>, a plant known for its medicinal properties, against gastric mucosal damage. Rats were administered alcohol to induce gastric ulcers and subsequently treated with <em>Sphagneticola trilobata </em>extract. Gastric lesions were asses

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Vimala, G., and F. Gricilda Shoba. "A Review on Antiulcer Activity of Few Indian Medicinal Plants." International Journal of Microbiology 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/519590.

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Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gast

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Martinez, Glendy Alejandra. "Risk Factors for Developing Peptic Ulcer Disease." International Journal Of Medical Science And Clinical Research Studies 03, no. 02 (2023): 174–76. https://doi.org/10.5281/zenodo.7611536.

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Peptic ulcer disease (PUD) is predicted to affect between 0.1 and 0.3 percent of the population each year. PUD develops at a rate of roughly 1% per year in Helicobacter pylori (H. pylori) infected persons, which is 6 to 10 times higher than in uninfected people. The prevalence of PUD increases with age in both duodenal and stomach ulcers. Two factors contribute to peptic ulcer disease: H. pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs have also been related to an increased risk of complications from peptic ulcer disease, such as gastrointestinal bleeding,

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Groenen, Marcel JM, Ernst J. Kuipers, Bettina E. Hansen, and Rob J. Th Ouwendijk. "Incidence of Duodenal Ulcers and Gastric Ulcers in a Western Population: Back to Where It Started." Canadian Journal of Gastroenterology 23, no. 9 (2009): 604–8. http://dx.doi.org/10.1155/2009/181059.

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BACKGROUND/OBJECTIVES: As recently as 40 years ago, a decline in the incidence of peptic ulcers was observed. The discovery of Helicobacter pylori had a further major impact on the incidence of ulcer disease. Our aim was to evaluate the trends in the incidence and bleeding complications of ulcer disease in the Netherlands.METHODS: From a computerized endoscopy database of a district hospital, the data of all patients who underwent upper gastrointestinal endoscopy from 1996 to 2005 were analyzed. The incidence of duodenal and gastric ulcers, with and without complications, were compared over ti

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PA, Akah. "Evaluation of the Gastric Antiulcer Efficacy of Helianthus annuus L, Leaves Extract and Fractions." Journal of Natural & Ayurvedic Medicine 4, no. 2 (2020): 1–9. http://dx.doi.org/10.23880/jonam-16000251.

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Peptic ulcer disease is one of the most common gastrointestinal diseases worldwide. Its treatment is becoming increasingly difficult due to the implication of Helicobacter pylori and its increasing resistance to antimicrobial agents leading to a cyclical course of exacerbation and remission. This study evaluated the antiulcer effects of methanol leaf extract and fractions of Helianthus annuus. The crude extract was prepared by cold maceration with methanol. A portion of the extract (300 g) was partitioned with n-hexane, ethyl acetate and methanol to yield n-hexane (HF), ethyl acetate (EF) and

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Sagdati, S., and S. Milinić. "HELICOBACTER PYLORI INFECTION AND ASSOCIATED DISEASE AT DIFFERENT AGES AND SEX." Praxis medica 38, no. 1 (2010): 87–90. http://dx.doi.org/10.70949/pramed201001333s.

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&lt;p&gt;The discovery of Helicobacter pylori (Hp) and the causal relationship between Helicobacter pylori infection with chronic gastritis, gastric and duodenal ulcers and gastric cancer is an epochal event in recent times. The aim of this study was to examine the prevalence of Hp infection and prove the connection between Helicobacter pylori infection and gastric and duodenal diseases in different age and gender categories. Study included 250 subjects of both sexes, different age groups selected random sample. All respondents were subjected to Hp urease test from biopsy specimens of

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Srivastava, Vivek, Priyanka Gupta, and Deepika Sharma. "EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF LAGENARIA SICERARIA." Journal of Applied Pharmaceutical Sciences and Research 4, no. 2 (2021): 15–20. http://dx.doi.org/10.31069/japsr.v4i2.4.

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Introduction: Ulcer is a common gastrointestinal disorder and can be characterized by inflamed lesions of the mucosa and tissue that protect the gastrointestinal tract. These ulcers can develop when the imbalance occurs between the gastroprotective (mucus, bicarbonate, and prostaglandins) and aggressive (acid, pepsin, bile salts, and Helicobacter pylori bacteria). According to research and as other species from genus Lagenaria shows analgesic, anti-inflammatory, immunomodulatory, antihyperlipidemic, diuretic, and antihelmintic activities on the fruit of Lagenaria siceraria. Methods: The

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Case Jr, Robert, Patrick Stoner, Samuel Myrick, and Ellen Zimmermann. "Solitary ascending colon ulcer diagnosed as gastrointestinal CMV disease." BMJ Case Reports 12, no. 2 (2019): bcr—2018–226355. http://dx.doi.org/10.1136/bcr-2018-226355.

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A 42-year-old woman with a history of cholangiocarcinoma on adjuvant chemotherapy with capecitabine presented with painless haematochezia. She was found to have an isolated twenty-five mm ulcer in the ascending colon. Biopsies of the ulceration demonstrated typical cytomegalovirus (CMV) inclusions and her peripheral blood CMV PCR was significantly elevated. This is an unusual case of a solitary proximal colon ulcer. Non-steroidal anti-inflammatory drugs, inflammatory bowel disease and malignancy, are the most frequent causes of isolated ulcers in the proximal colon. Gastrointestinal (GI) CMV d

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Mukherjee, Deepannita Roy, Sayak Tanbir, Sohel Mondal, et al. "Exploring the Gut Microbiome's Influence on Peptic Ulcer Disease: Mechanistic Insights, Pharmacological Implications, and Emerging Therapeutic Strategies." Journal of Drug Delivery and Therapeutics 15, no. 4 (2025): 209–18. https://doi.org/10.22270/jddt.v15i4.7088.

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Background: The gastrointestinal disorder Peptic Ulcer Disease (PUD) leads to mucosal damage in either stomach or duodenal tissue because of acid-peptic injury. The available evidence demonstrates that Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) usage serve as proven ulcer causes but new research shows the gut microbiome as contributing to ulcer development and therapeutic approaches. Objective: The purpose of this section is to examine the standard H. pylori ulcer development process while examining host immune responses through gut microbial alte

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Ray-Offor, Emeka, and Kalanne Ada Opusunju. "Current status of peptic ulcer disease in Port Harcourt metropolis, Nigeria." African Health Sciences 20, no. 3 (2020): 1446–51. http://dx.doi.org/10.4314/ahs.v20i3.50.

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Background: Epidemiological studies on peptic ulcer disease (PUD) have shown a recent decrease in hospital admissions in Western countries. Objective: This paper aimed to study the current status and risk factors of PUD in a Nigerian metropolis. Methods: A cross-sectional study of symptomatic patients at upper gastrointestinal (GI) endoscopy diagnosed with PUD from February 2014 to September 2019 at a referral endoscopy facility in Port Harcourt, Niger delta region of Nigeria. The variables studied included demographics, symptoms and duration, blood group, chronic non-steroidal ant

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Williams, R., E.-N. Ialani, and G. W. H. Stamp. "Natural Gastrointestinal Ulcer Healing Mechanism?" Journal of the Royal Society of Medicine 87, no. 11 (1994): 649–51. http://dx.doi.org/10.1177/014107689408701104.

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Pattullo, V., J. Tomlinson, and C. Bell. "Gastrointestinal: Solitary rectal ulcer syndrome." Journal of Gastroenterology and Hepatology 22, no. 12 (2007): 2362. http://dx.doi.org/10.1111/j.1440-1746.2007.05231.x.

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Dzhaksymbaev, N., O. Kochorov, B. Niyazov, S. Niyazova, and O. Dinlossan. "Endoscopic Hemostasis in Ulcer Gastroduodenal Bleeding." Bulletin of Science and Practice 11, no. 1 (2025): 97–104. https://doi.org/10.33619/2414-2948/110/14.

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Gastroduodenal hemorrhages are bleedings in which blood flows from an ulcerated area affected by an inflammatory process with damage to a blood vessel and from where it flows in a stream or drip into the lumen of the gastrointestinal tract. The stomach and duodenum are most often the source of hemorrhage. This is always a formidable complication and a dangerous condition that often poses a threat to life and often ends in death. However, this is not the only variant of internal bleeding with effusion into the gastrointestinal tract: in a number of diseases - varicose veins of the esophagus, no

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Mantry, Shubhrajit, Sahil Shaikh, Shubham Shinde, Shital Bidkar, and Ganesh Dama. "Preliminary Study on the Composition of Nanoparticles for the Treatment of Peptic Ulcer." International Journal of Current Research and Review 14, no. 08 (2022): 16–25. http://dx.doi.org/10.31782/ijcrr.2022.14803.

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One of the most frequent gastrointestinal issues is a gastric ulcer. Throughout their lives, peptic ulcer disease affects more than 10% of the adult population in Western countries. The pathogenesis of peptic ulcer disease is based on an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and hazardous chemicals (acid and pepsin). Certain acid-related illnesses can be addressed and prevented by lowering gastric acidity or improving mucosal protection. In the treatment of stomach ulcers, nanoparticles are being devel

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MAHMOOD, KHALID, Hamzullah Khan, ZIA-U. DIN, Riaz Mohammad, MOHAMMAD ILYAS SAEEDI, and Mustafa Kamal. "DIAGNOSTIC UPPER GASTROINTESTINAL ENDOSCOP." Professional Medical Journal 16, no. 04 (2009): 503–9. http://dx.doi.org/10.29309/tpmj/2009.16.04.2725.

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O b j e c t i v e : To evaluate Oesophagogastroduedensocopy (OGD) in term of it's indications and endoscopic findings. Design:Retrospective, audit.Place a n d d u r a t i o n of t h e study: Medical "C" unit, Department of Medicine Government Lady Reading Hospital PostGraduate Medical Institute Khyber Medical University Peshawar from July 2002 to June 2007. S u b j e c t s a n d M e t h o d s : Adult patients whounderwent upper gastrointestinal (Gl) endoscopies during the last 5 years period were included in the study. The procedure was performedas per the standard protocol with diagnosis base

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Al-Ganmi, Ali Hussein Alek, Haider Mohammed Majeed, and Ahmed Fleih Hassan. "Examining of Predictive Factors for Developing Gastroduodenal Ulcer among Patients Attending Gastrointestinal Teaching Hospitals in Baghdad." Journal of Nature and Science of Medicine 8, no. 2 (2025): 146–50. https://doi.org/10.4103/jnsm.jnsm_107_24.

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Background and Objectives: Duodenal and gastric ulcers remain the two most common perforations of the gastrointestinal tract and might be reduced by the early detection of predictive factors, which has limitedly researched. This study conducted to examine the predictive factors for developing of gastroduodenal ulcer among patients attending Gastrointestinal Teaching Hospitals in Baghdad, Iraq. Materials and Methods: A cross-sectional survey with a total of 100 patients with gastric and duodenal ulcers was recruited using a nonprobability (purposive) sampling technique from September 10, 2022 t

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Sheptulin, Arkadiy A. "Contribution of Vladimir Kharitonovich Vasilenko and his disciples to the study of ulcer disease." Clinical Medicine (Russian Journal) 95, no. 6 (2017): 495–98. http://dx.doi.org/10.18821/0023-2149-2017-95-6-495-498.

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The article outlines the contribution of V.Kh. Vasilenko and his disciples to the study of ulcer disease including substantiation of its pathogenesis as a result of disbalance between the aggressive action of acidic and peptic factors and protective potential of gastric and duodenal mucosa based on the evaluation of their role in mucus production, epithelial cell regeneration, secretion of gastrointestinal peptides, and other processes. Special emphasis is laid on the differentiation between ulcer disease and symptomatic gastroduodenal ulcers as proposed by Vasilenko, his analysis of the clini

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Ergashov, Ozodjon Ilkhomovich. "The Importance of Plant Extract in Improving the Microflora of the Gastrointestinal Tract in the Treatment of Diseases of the Stomach and Duodenum." Aug-Sep 2023, no. 35 (August 8, 2023): 12–18. http://dx.doi.org/10.55529/jhtd.35.12.18.

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The paper presents the results of studying the anti-ulcer activity of a combination of complex plant extracts on experimental models of stress and acetylsalicylic gastric ulcers when administered per os extract at a dose of 150 mg/ kg to laboratory animals. The experiments were performed on nonlinear male rats and mongrel male mice. Determination of the Pauls index, the anti–ulcer action index (AUE) - the main criteria for evaluating the anti-ulcer activity of drugs. It is shown that in stress ulcers, the effectiveness of the extract is characterized by a decrease in large, point, stripe-shape

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van de Laar, Mart A. F. J., Rainer Schöfl, Marlou Prevoo, and Jan Jastorff. "Predictive value of gastrointestinal symptoms and patient risk factors for NSAID-associated gastrointestinal ulcers defined by endoscopy? Insights from a pooled analysis of two naproxen clinical trials." PLOS ONE 18, no. 4 (2023): e0284358. http://dx.doi.org/10.1371/journal.pone.0284358.

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Objective Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain and rheumatic conditions. To facilitate patient management, we determined the predictive value of gastrointestinal (GI) symptoms and risk factors for the development of NSAID-associated GI injuries. Methods Post-hoc analysis of pooled data from naproxen treatment arms of two identical, randomized, double-blind, controlled phase 3 trials in arthritis patients at risk of GI adverse events. Endoscopic incidence of GI ulcers at baseline, and 1, 3, and 6 months was employed as a surrogate parameter for GI injury.

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Byrne, William J. "Diagnosis and Treatment of Peptic Ulcer Disease in Children." Pediatrics In Review 7, no. 6 (1985): 182–90. http://dx.doi.org/10.1542/pir.7.6.182.

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With advances in diagnostic technology, specifically upper gastrointestinal tract endoscopy, peptic ulcer disease in infants and children should no longer be considered rare. Whereas secondary ulcers are usually gastric and are often multiple, primary ulcers occur with almost equal frequency in the duodenum or stomach and tend to be solitary. In spite of intensive scientific investigation, the etiology of peptic ulcer disease remains unclear. Genetic factors appear to play a role and a polygenic mode of inheritance has been proposed. Emotional factors also seem to be important. Children with p

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Brodaric, Alen, and Rajkumar Srinivasan. "Life-threatening upper gastrointestinal hemorrhage from a Cameron ulcer." Journal of Case Reports and Images in Surgery 10, no. 1 (2024): 1–5. http://dx.doi.org/10.5348/100128z12ab2024cr.

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Introduction: Acute upper gastrointestinal bleeding can be life-threatening; however, Cameron lesions are an uncommon etiology. These lesions should be suspected with a previous history or endoscopic evidence of hiatus hernia. Case Report: A male in his 60s presented to the emergency department with hematemesis and melena for two days. He had no prior medical, surgical, or endoscopic history and took no regular medications. He was resuscitated with packed red blood cell transfusion and treated with proton pump inhibitor infusion then transferred to operating theaters for endoscopic hemostasis.

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Oraekei, Daniel Ikechukwu, Sonne Ikechukwu Mbagwu, and Kelechukwu Emmanuel Iduma. "Evaluation of the pharmacological interactions between coadministered Newbouldia laevis root bark extract and omeprazole in ulcer induced rat model." Journal of Current Biomedical Research 2, no. 6, November-December (2022): 659–67. http://dx.doi.org/10.54117/jcbr.v2i6.7.

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Ulcers are wounds on the lining of the gastrointestinal tract. There are different types of ulcers some of which include: duodenal, gastric and esophageal ulcers. The most common type of ulcers is peptic ulcers which occur mostly in those portions that come into contact with stomach acids and enzymes. Other causes of ulcers comprise antibiotics, anti-inflammatory drugs, alcohol and a microorganism called Helicobacter pylori. There are numerous antiulcer drugs in current use. These drugs are associated with many problems some of which are life-threatening. In other to avert these complications,

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