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Journal articles on the topic 'Gastroprotective agents'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Nagy, Lajos, Romeo E. Morales, Martin Beinborn, Peter Vattay, and Sandor Szabo. "Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 6 (2000): G1201—G1208. http://dx.doi.org/10.1152/ajpgi.2000.279.6.g1201.

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We tested the hypothesis that recognized gastroprotective agents exert direct protection against ethanol-induced injury in isolated rat gastric mucosal cells in vitro. If protection exists, we also wanted to identify subcellular targets in the reversible and/or irreversible stages of cell injury. Ethanol-induced cell injury was quantified by measuring plasma membrane leakage (trypan blue exclusion and lactate dehydrogenase release), mitochondrial integrity (succinic dehydrogenase), and nuclear damage (ethidium bromide-DNA fluorescence). Initial cell viability and responsiveness were estimated

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2

Jones, Rachel. "Gastroprotective agents are underprescribed among NSAID users." Nature Reviews Gastroenterology & Hepatology 7, no. 7 (2010): 360. http://dx.doi.org/10.1038/nrgastro.2010.94.

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3

Ardiles, Alejandro, Ruth Barrientos, Mario Simirgiotis, Jorge Bórquez, Beatriz Sepúlveda, and Carlos Areche. "Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert." Molecules 23, no. 9 (2018): 2361. http://dx.doi.org/10.3390/molecules23092361.

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Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytre

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4

Mandel, K. G., T. A. Bertram, M. K. Eichhold, S. C. Pepple, and M. J. Doyle. "Fatty Acid-mediated Gastroprotection Does Not Correlate with Prostaglandin Elevation in Rats Exposed to Various Chemical Insults." Veterinary Pathology 31, no. 6 (1994): 679–88. http://dx.doi.org/10.1177/030098589403100608.

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This study involved a comparison of activity of several long-chain fatty acids (arachidonic acid, dihomo-[γ]-linolenic acid, linoleic acid, and oleic acid) for protection against gastric mucosal damage elicited by taurocholic acid, acidified aspirin, and ethanol in rats. Each damaging agent induced gastric mucosal lesions in the corpus. Mucosal damage was induced by all agents, and all fatty acids protected the gastric mucosa; however, ethanol and arachidonic acid were the most potent damaging and protecting agents, respectively. Maximally protective doses for prevention of taurocholic acid-in

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Slomiany, B. L., V. L. N. Murty, J. Piotrowski, and A. Slomiany. "Gastroprotective agents in mucosal defense against Helicobacter pylori." General Pharmacology: The Vascular System 25, no. 5 (1994): 833–41. http://dx.doi.org/10.1016/0306-3623(94)90084-1.

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6

Tundis, Rosa, Monica R. Loizzo, Marco Bonesi, et al. "Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301234.

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Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus b

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PUIA, Aida, Diana SCHLANGER, and Ion C. PUIA. "The role of medicinal mushrooms as gastroprotective agents: A short narrative review." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 51, no. 4 (2023): 13532. http://dx.doi.org/10.15835/nbha51413532.

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This review examines the possible clinical uses of extracts from mushrooms with medicinal properties, particularly their role as gastroprotective agents. After conducting a thorough examination of the literature, we identified and chose publications that presented six distinct types of mushroom extracts. These extracts have been experimentally demonstrated to have gastroprotective effects in animal models. Animals like rats or mice were used as subjects in experimental models to generate stomach ulcers through various approaches, such as chemical induction or inducing stress. Studies have show

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8

Majeed, Wafa, Tanweer Khaliq, Bilal Aslam, Junaid Ali Khan, and Asra Iftikhar. "Medicinal plants with gastroprotective potential." Bangladesh Journal of Pharmacology 10, no. 3 (2015): 588. http://dx.doi.org/10.3329/bjp.v10i3.23578.

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants

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9

Kudryavtsev, Konstantin V., Anna O. Markevich, Oleksandr V. Virchenko, et al. "Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile." Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/217039.

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This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluatedin vivoat water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1

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10

Cucala, M., P. Bauerfeind, C. Emde, J. J. Gonvers, H. R. Koelz, and A. L. Blum. "Is it Wise to Prescribe NSAIDs with Modern Gastroprotective Agents?" Scandinavian Journal of Rheumatology 16, sup65 (1987): 141–54. http://dx.doi.org/10.3109/03009748709102193.

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11

Ares, Jeffrey J., Pamela E. Outt, Jared L. Randall, et al. "Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents." Journal of Medicinal Chemistry 38, no. 25 (1995): 4937–43. http://dx.doi.org/10.1021/jm00025a011.

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12

Henry, Patricia, Fedele DePalma, Philip Elbaum, Nonye Enyinna, M. Ellionore Jarbrink-Sehgal, and Louis Chaptini. "Su1778 Adherence to Gastroprotective Agents in Patients Discharged on Aspirin." Gastroenterology 142, no. 5 (2012): S—501. http://dx.doi.org/10.1016/s0016-5085(12)61920-9.

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13

Ragab, Fatma A., Ghaneya S. Hassan, Hanan A. Yossef, and Hanna A. Hashem. "Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents." European Journal of Medicinal Chemistry 42, no. 8 (2007): 1117–27. http://dx.doi.org/10.1016/j.ejmech.2007.01.019.

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14

Frolova, A. A., T. S. Shindina, L. V. Maslovsky, M. L. Maksimov, E. B. Aleksandrova, and O. E. Kropova. "Mechanism of action of gastroprotective agent rebamipide." Glavvrač (Chief Medical Officer), no. 8 (July 25, 2022): 23–25. http://dx.doi.org/10.33920/med-03-2208-06.

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Among the diseases of the digestive system, a significant place is occupied by acid-dependent diseases caused by excessive secretion of hydrochloric acid secreted by the parietal cells of the gastric mucosa. Due to their high prevalence and risk of complications, these pathologies represent a serious medical and social problem. Gastroprotective agents have a protective effect on the mucous membrane of the stomach and intestines. This group of medicines includes a range of drugs that differ in principle and mechanism of action, such as misoprostol, bismuth salts, as well as some herbal preparat

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15

Qader, Suhailah Wasman, Lee Suan Chua, Janelle Fournier, and Mehmet Ozdemir. "Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions." Journal of Pharmacy and Nutrition Sciences 12 (December 27, 2022): 94–108. http://dx.doi.org/10.29169/1927-5951.2022.12.09.

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Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important to discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian plants were collected and analyzed to understand the underlying pathways. Keywords include peptic ulcer, gastric ulcer, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Helicobacterpylori, medicinal plant, gastroprotection, antiulcer, acid secretion, cytoprotective, and digestion processes were applied in the search engi

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Manohar, VS, M. Vinay, T. Jayasree, PV Kishan, S. Ubedulla, and Rohit Dixit. "Prescribing pattern of gastroprotective agents with non-steroidal anti-inflammatory drugs." Journal of Pharmacology and Pharmacotherapeutics 4, no. 1 (2013): 59. http://dx.doi.org/10.4103/0976-500x.107684.

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17

ARES, J. J., and P. E. OUTT. "ChemInform Abstract: Gastroprotective Agents for the Prevention of NSAID-Induced Gastropathy." ChemInform 29, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199825357.

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18

S, Menaga, Kripa Kg, and Sangeetha R. "EVALUATION OF IN VITRO INHIBITION OF PROTON􀇧PUMP BY NANOSILVER PARTICLES SYNTHESIZED USING SEEDS OF ANETHUM GRAVEOLENS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 363. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.16896.

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Objective: The green synthesis of nanoparticles is gaining popularity owing to its several advantages over the chemical methods. This study reports the biosynthesis of nanosilver mediated by the extract of the seeds of Anethum graveolens.Methods: Green synthesis of silver nanoparticles (AgNPs) was carried out using the aqueous extract of the seeds of A. graveolens (AESE). Microwave irradiation was done to hasten the process. The AgNPs synthesized were physically characterized using ultraviolet-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and scanning electro

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19

Cascinu, Stefano, Stefano Luzi Fedeli, Anna Fedeli, and Giuseppina Catalano. "Gastric Metastases from Breast Cancer: A Case Report." Tumori Journal 75, no. 2 (1989): 150–51. http://dx.doi.org/10.1177/030089168907500214.

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We describe a case of a 50 year old woman with a secondary involvement of the stomach from breast carcinoma. She complained of nausea, vomiting and epigastric pain resistant to gastroprotective drugs. Initially symptoms were attributed to the side effects of chemotherapeutic agents. Correct diagnosis led to effective treatment of gastrointestinal symptoms with consequent improvement in her quality of life.

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20

NESELLO, Luciane Angela Nottar, Adriana CAMPOS, Roseane Leandra da ROSA, Sérgio Faloni de ANDRADE, and Valdir CECHINEL FILHO. "SCREENING OF WILD FRUIT TREES WITH GASTROPROTECTIVE ACTIVITY IN DIFFERENT EXPERIMENTAL MODELS." Arquivos de Gastroenterologia 54, no. 2 (2017): 135–38. http://dx.doi.org/10.1590/s0004-2803.201700000-13.

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ABSTRACT BACKGROUND Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. OBJECTIVE The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. METHODS The different parts of the fruits were separately subjected to a process of extraction by methanol. Two

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21

Almashal, Faeza. "Synthesis of Some new Sulfonamide Schiff’s Bases and Study Their Gastroprotective Activity." University of Thi-Qar Journal of Science 3, no. 4 (2013): 117–30. http://dx.doi.org/10.32792/utq/utjsci/v3i4.528.

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Substituted sulfonamides were reacted with thiophene carbaldehydes and piperenal to form Schiff’s bases. The structures of synthesized compounds were confirmed by their IR,1 H NMR spectroscopic data and mass spectra.Different necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl) were used to induced gastric lesions. The compounds were given orally 30 min before the administration of necrotizing agents. The percentages for compounds to ulcer protective were calculated. Compound 4 was more effective than other compounds and omeprazole itself.Compound 1 was approximate equal to omeprazole act

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22

Howden, C. W. "Commentary: improving the use of gastroprotective agents among high-risk NSAID users." Alimentary Pharmacology & Therapeutics 37, no. 10 (2013): 1019. http://dx.doi.org/10.1111/apt.12281.

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23

Ares, Jeffrey J., Pamela E. Outt, Jared L. Randall, et al. "Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents." Bioorganic & Medicinal Chemistry Letters 6, no. 8 (1996): 995–98. http://dx.doi.org/10.1016/0960-894x(96)00134-5.

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24

ARES, J. J., P. E. OUTT, J. L. RANDALL, et al. "ChemInform Abstract: Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents." ChemInform 27, no. 16 (2010): no. http://dx.doi.org/10.1002/chin.199616163.

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25

Lien, Hsiu-Man, Yu-Yen Wang, Mei-Zi Huang, et al. "Gastroprotective Effect of Anisomeles indica on Aspirin-Induced Gastric Ulcer in Mice." Antioxidants 11, no. 12 (2022): 2327. http://dx.doi.org/10.3390/antiox11122327.

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Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the Helicobacter pylori infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-H. pylori and anti-gastric cancer activities of Anisomeles indica, its gastroprotective effect on ulcers

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26

Zhang, Bowei, Xiaoxiao Rao, Yunhui Zhang, et al. "Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice." Antioxidants 11, no. 12 (2022): 2459. http://dx.doi.org/10.3390/antiox11122459.

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Foxtail millet has been traditionally considered to possess gastroprotective effects, but studies evaluating its use as a treatment for gastric ulcers are lacking. Here, we assessed the antiulcer effects of foxtail millet protein hydrolysate (FPH) and explored its mechanism by using blocking agents. In a mouse model of ethanol-induced gastric ulcers, pretreatment with FPH reduced the ulcerative lesion index, downregulated the expression of inflammatory cytokines in the gastric tissue, increased the activity of antioxidant enzymes, and improved the oxidative status. FPH increased constitutive t

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27

Saldanha, Lynel Venston, Josina John, Abdul Javad K, et al. "Usage Pattern of Gastroprotective Agents Among Patients Prescribed with NSAIDS in Orthopedics Department." International Journal of Current Research and Review 13, no. 03 (2021): 126–31. http://dx.doi.org/10.31782/ijcrr.2021.13308.

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28

Mateo, H., J. Fernandez Ávila, P. Nieto Guindo, FD Fernández Ginés, and M. Giménez Ramos. "GRP-076 Gastroprotective Agents in the Emergency Room of a Tertiary-Level Hospital." European Journal of Hospital Pharmacy 20, Suppl 1 (2013): A27.3—A28. http://dx.doi.org/10.1136/ejhpharm-2013-000276.076.

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29

Chan, Esther W., Wallis C. Y. Lau, Wai K. Leung, et al. "Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study." Gastroenterology 149, no. 3 (2015): 586–95. http://dx.doi.org/10.1053/j.gastro.2015.05.002.

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Al-Yahya, M. A., S. Rafatullah, J. S. Mossa, A. M. Ageel, N. S. Parmar, and M. Tariq. "Gastroprotective Activity of Ginger Zingiber Officinale Rosc., in Albino Rats." American Journal of Chinese Medicine 17, no. 01n02 (1989): 51–56. http://dx.doi.org/10.1142/s0192415x89000097.

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The cytoprotective and gastric anti-ulcer studies of ginger have been carried out in albino rats. Cytodestruction was produced by 80% ethanol, 0.6M HC1, 0.2M NaOH and 25% NaC1. Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique. The results of this study demonstrate that the extract in the dose of 500 mg/kg orally exert highly significant cytoprotection against 80% ethanol, 0.6M HC1, 0.2M NaOH and 25% NaC1 induced gastric lesions. Th extract also prevented the oc

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Hurtubise, Raphaël, Marie Hudson, Geneviève Gyger, et al. "Association between gastroprotective agents and risk of incident interstitial lung disease in systemic sclerosis." Respiratory Medicine 185 (August 2021): 106482. http://dx.doi.org/10.1016/j.rmed.2021.106482.

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32

Youn, Sung Hee, Hyun Lim, Yeonmi Ju, et al. "Effect of gastroprotective agents on upper gastrointestinal bleeding in patients receiving direct oral anticoagulants." Scandinavian Journal of Gastroenterology 53, no. 12 (2018): 1490–95. http://dx.doi.org/10.1080/00365521.2018.1541478.

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Ho, C. W., and F. K. L. Chan. "Commentary: improving the use of gastroprotective agents among high-risk NSAID users - authors’ reply." Alimentary Pharmacology & Therapeutics 37, no. 10 (2013): 1019–20. http://dx.doi.org/10.1111/apt.12295.

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34

Valkhoff, Vera E., Eva M. van Soest, Giampiero Mazzaglia, et al. "Adherence to Gastroprotective Agents and the Risk of Upper Gastrointestinal Complications in Coxib Users." Gastroenterology 140, no. 5 (2011): S—585. http://dx.doi.org/10.1016/s0016-5085(11)62420-7.

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35

Bertin, Philippe. "Should gastroprotective agents be given with COX-2 inhibitors? A question worthy of scrutiny." Joint Bone Spine 71, no. 6 (2004): 454–56. http://dx.doi.org/10.1016/j.jbspin.2004.01.004.

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36

K B, Sanalkumar, Shenoy K T, Arun K, Hema Ilavarasi K M, Venugopalan P G, and Leena K B. "PATTERN OF USE OF GASTROPROTECTIVE AGENTS ALONG WITH THE ANTI – INFLAMMATORY AND ANALGESICS DRUGS." Journal of Evolution of Medical and Dental Sciences 5, no. 01 (2016): 50–54. http://dx.doi.org/10.14260/jemds/2016/12.

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Sruthi, Y.* Dr. Vishnu Kangralkar. "A Comprehensive Review of Experimental Models, Evaluation Parameters, And Natural-Synthetic Therapeutics for Peptic Ulcer Treatment." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 929–46. https://doi.org/10.5281/zenodo.15350568.

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Peptic ulcer disease (PUD) is a gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid and pepsin, and the protective mechanisms of the gastrointestinal mucosa. Common causes include Helicobacter pylori infection, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), alcohol intake, smoking, and dietary imbalances. Conventional therapeutic approaches, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists, have proven effective but are often associated with adverse effects, drug interactions, and high recurrence ra

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Foudah, Ahmed I., Fawwaz Khalaf Aloneizi, Mohammad H. Alqarni, et al. "Potential Active Constituents from Opophytum forsskalii (Hochst. ex Boiss.) N.E.Br against Experimental Gastric Lesions in Rats." Pharmaceuticals 15, no. 9 (2022): 1089. http://dx.doi.org/10.3390/ph15091089.

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Opophytum forsskalii (O. forsskalii) is a desert plant that belongs to the Aizoaceae family. Although it is a natural food source for Bedouin tribes in northern Saudi Arabia, there is little information on its active metabolites. Therefore, the secondary metabolites of the hydroalcoholic extract from the leaves of this species were analyzed by liquid chromatography-mass chromatography (LC-MS). LC-MS identified a total of 30 secondary metabolites. These compounds represented two main categories among sixteen classes. Among them, flavonoids represented the largest proportion with eleven metaboli

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Martín, M. J., C. La -Casa, C. Alarcón-de-la-Lastra, J. Cabeza, I. Villegas, and V. Motilva. "Anti-Oxidant Mechanisms Involved in Gastroprotective Effects of Quercetin." Zeitschrift für Naturforschung C 53, no. 1-2 (1998): 82–88. http://dx.doi.org/10.1515/znc-1998-1-215.

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Abstract The anti-ulcerogenic and anti-oxidant effects of various flavonoids have been frequently reported. We investigated the cytoprotective properties of quercetin, a natural flavone, in gastric mucosal injury induced by 50% ethanol, since in this experimental model the pathogenesis of the lesions has been related with production of reactive oxygen species. The involvement of neutrophil infiltration and the capacity of this flavonoid to restrain the oxidative process produced in the gastric tissue after ethanol administration were also investigated. Oral pretreatment with the highest dos

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Lister, S., G. Makinson, and T. Koncz. "PAR9 CO-PRESCRIPTION OF GASTROPROTECTIVE AGENTS FOR PATIENTS AT RISK OF NSNSAID-INDUCED GASTROINTESTINAL HARM." Value in Health 9, no. 6 (2006): A223. http://dx.doi.org/10.1016/s1098-3015(10)63268-8.

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Karoui, Amine, Fatma Allouche, Monia Deghrigue, Asma Agrebi, Abderrahman Bouraoui, and Fakher Chabchoub. "Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats." Medicinal Chemistry Research 23, no. 3 (2013): 1591–98. http://dx.doi.org/10.1007/s00044-013-0742-x.

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Ray, Arunabha, Kavita Gulati, and Peter Henke. "Stress Gastric Ulcers and Cytoprotective Strategies: Perspectives and Trends." Current Pharmaceutical Design 26, no. 25 (2020): 2982–90. http://dx.doi.org/10.2174/1381612826666200521143203.

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Stress gastric ulceration is a clinical condition leading to morbidity/mortality and complex etiopathological factors are involved. Pharmacotherapy of such gastric mucosal lesions is not consistent and novel strategies are being explored. Targeting gastrointestinal factors have showed equivocal results and there is a possibility of involvement of extra-gastrointestinal factors. Stress is a highly interactive biological response in which the brain plays a key role. The involvement of brain substrates like the limbic system (amygdala, cortex, hippocampus) and behavioral traits has been investiga

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Srivastava, Vivek, Priyanka Gupta, and Deepika Sharma. "EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF LAGENARIA SICERARIA." Journal of Applied Pharmaceutical Sciences and Research 4, no. 2 (2021): 15–20. http://dx.doi.org/10.31069/japsr.v4i2.4.

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Introduction: Ulcer is a common gastrointestinal disorder and can be characterized by inflamed lesions of the mucosa and tissue that protect the gastrointestinal tract. These ulcers can develop when the imbalance occurs between the gastroprotective (mucus, bicarbonate, and prostaglandins) and aggressive (acid, pepsin, bile salts, and Helicobacter pylori bacteria). According to research and as other species from genus Lagenaria shows analgesic, anti-inflammatory, immunomodulatory, antihyperlipidemic, diuretic, and antihelmintic activities on the fruit of Lagenaria siceraria. Methods: The

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Elshamy, Abdelsamed I., Abdel Razik H. Farrag, Iriny M. Ayoub, et al. "UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract." Molecules 25, no. 18 (2020): 4234. http://dx.doi.org/10.3390/molecules25184234.

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Cyperus has been commonly used as a multi-use medicinal plant in folk medicine worldwide. The objectives of our study were to determine the different metabolites in the Cyperus conglomeratus Rottb. methanol extract, and to assess its in vivo gastroprotective effect in ethanol-induced gastric ulcer model in rats. Serum levels of galactin-3 and TNF-α were employed as biochemical markers. To pinpoint for active agents, comprehensive metabolites profiling of extract via UPLC-qTOF-MS/MS was employed. A total of 77 chromatographic peaks were detected, of which 70 were annotated. The detected metabol

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Kartheek, Chegu* Innaiah Nallaboina Divya Billi Ajay Babu Palaparthi. "A REVIEW ON SOME HOME REMEDIES ACT AS GASRTOPROTECTIVE ACTIVITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4640–43. https://doi.org/10.5281/zenodo.2581500.

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<em>Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract.</em><em> Peptic ulcers include Gastric ulcers that occur on the inside of the stomach and duodenal ulcers that occur on the inside of the upper portion of your small intestine (duodenum). The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of aspirin and certain other painkillers, such as ibuprofen and naproxen sodium. The most common pept

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Yamamoto, Takatsugu, Taro Ishii, Kengo Hattori, et al. "Possible Role of Gastroprotective Agents On Preventing Gastroduodenal Mucosal Injury in Patients Taking Low-Dose Aspirin." Gastrointestinal Endoscopy 67, no. 5 (2008): AB276—AB277. http://dx.doi.org/10.1016/j.gie.2008.03.775.

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Erdeljic, Viktorija, Igor Francetic, Viola Macolic Sarinic, et al. "Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study." Pharmacy World & Science 28, no. 5 (2006): 318–25. http://dx.doi.org/10.1007/s11096-006-9062-2.

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Ragab, Tamer I. M., Abdulsalam M. Kassem, Heba M. I. Abdallah та ін. "Phytol nanoemulsions encapsulated alginate hydrogel beads for the protection and management of alcohol-induced gastric ulcer via nitric oxide synthase and NF-κB/IL-6/TGF-β modulation". PLOS One 20, № 7 (2025): e0327368. https://doi.org/10.1371/journal.pone.0327368.

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Background Innovative treatment strategies are required for stomach ulcers because of their multifactorial nature. Nanotechnology has emerged as a promising and transformative platform for the formulation and targeted delivery of therapeutic agents. Methods and findings The gastroprotective potential of both in its free form and encapsulated in calcium alginate beads was evaluated against ethanol-induced gastric ulceration in rats. Phytol-loaded nanoemulsions were incorporated into alginate beads to achieve controlled release. Alginate beads showed a pH-dependent release pattern. The release b

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Ismail, Muhajira, Rahmat Abubakar, Abubakar Sadiq Mohammed, and Idris Mohammed Maje. "Gastroprotective Activity Of Methanol Extract Of Mesocarp Of Unripe Carica Papaya Linn. Fruit On Experimentally-induced Gastric Ulcer In Wistar Rats." Jewel Journal of Medical Sciences 2, no. 2 (2021): 171–85. http://dx.doi.org/10.56167/jjms.2021.0202.21.

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Background: Peptic ulcer affects up to 10 % of the world’s population. There has been renewed interest in identifying natural drug sources with gastroprotective activity. Unripe Carica papaya fruit is used traditionally for the treatment of various gastrointestinal disorders including peptic ulcer which may have not been well explored. Objective: The aim of this study was to determine the gastroprotective activity of methanol extract of mesocarp of unripe Carica papaya fruit (MECP) on experimentally-induced gastric ulcer in Wistar rats. Methodology: Forty-six (46) wistar rats (150 g to 170 g)

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Trush, E. A., A. I. Ulyanin, A. V. Korolev, et al. "A case report of a patient with isolated Crohn’s disease of the stomach." Voprosy detskoj dietologii 19, no. 3 (2021): 95–101. http://dx.doi.org/10.20953/1727-5784-2021-3-95-101.

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Crohn’s disease of the esophagus, stomach or duodenum is extremely rare and characterized by an aggressive disease course with a poor prognosis. Clinical symptoms of the upper gastrointestinal tract lesion are nonspecific, therefore esophagogastroduodenoscopy with biopsy is necessary for the differential diagnosis. Crohn’s disease of the stomach is characterized by a specific endoscopic finding – bamboo-joint-like appearance of gastric folds. Granulomatous inflammation in morphological examination of gastric biopsies in patients with Crohn’s disease is rare, therefore endoscopic finding is mor

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