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Relevant bibliographies by topics / GC side-effects

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Academic literature on the topic 'GC side-effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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Journal articles on the topic "GC side-effects"

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Lylova, E. S., A. V. Savinkova, E. M. Zhidkova, et al. "INHIBITION OF REDD1 EXPRESSION FOR THE REDUCTION OF GLUCOCORTICOID-INDUCED SIDE EFFECTS." Siberian journal of oncology 19, no. 6 (2020): 73–81. http://dx.doi.org/10.21294/1814-4861-2020-19-6-73-81.

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Glucocorticoids (GC ) have been an integral component of the treatment of leukemias and lymphomas for several decades. Specific cytotoxic effect of GC on transformed lymphoblasts mediates their use at the stage of the remission induction as well as consolidation of treatment. However, the main problem of the long-term GC use is the development of atrophic and metabolic side effects as well as GC resistance. The biological effects of GC are realized via activation of the glucocorticoid receptor (GR) by two mechanisms: transrepression (TR) associated with the therapeutic effects of GC , and tran

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Hua, Guoqiang, Naimah Zein, Laetitia Paulen, and Pierre Chambon. "The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids." Proceedings of the National Academy of Sciences 116, no. 28 (2019): 14200–14209. http://dx.doi.org/10.1073/pnas.1908264116.

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Seventy years after the discovery of their anti-inflammatory properties, glucocorticoids (GCs) remain the mainstay treatment for major allergic and inflammatory disorders, such as atopic dermatitis, asthma, rheumatoid arthritis, colitis, and conjunctivitis, among others. However, their long-term therapeutical administration is limited by major debilitating side effects, e.g., skin atrophy, osteoporosis, Addison-like adrenal insufficiency, fatty liver, and type 2 diabetes syndrome, as well as growth inhibition in children. These undesirable side effects are mostly related to GC-induced activati

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Catley, Matthew C. "Dissociated Steroids." Scientific World JOURNAL 7 (2007): 421–30. http://dx.doi.org/10.1100/tsw.2007.97.

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Glucocorticoids (GCs) are some of the most important drugs in clinical use today. They are mainly used to suppress disease-related inflammation and are widely used for the treatment of many inflammatory diseases including asthma and arthritis. However, GCs are also associated with debilitating side effects that place limitations on the long-term use of these drugs. The development of a GC with reduced side effects would allow more effective treatments for patients who require long-term suppression of inflammation. GCs exert their effects by binding and activating the GC receptor (GR). The acti

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Irawan, Andri. "Potensi Cadangan dan Serapan Karbon oleh Padang Lamun di bagian Utara dan Timur Pulau Bintan." Oseanologi dan Limnologi di Indonesia 2, no. 3 (2017): 35. http://dx.doi.org/10.14203/oldi.2017.v2i3.158.

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<strong>The Carbon Stock and Potential Uptake of Seagrass Beds in the Northern and Eastern Part of Bintan Island.</strong> Seagrass is marine plant vegetation which have large potention on reducing carbondioxide emission effects in the environment. Nevertheless, the information about this potention is still limited, so the seagrass beds are still having less attention. Therefore, in April 2016 a research has done to estimate the potential of carbon stock and uptake at two location in Bintan Island, that were in the northern part (Pengudang Village) and in the eastern part (Teluk Ba

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Ingawale, Deepa K., Satish K. Mandlik, and Snehal S. Patel. "An emphasis on molecular mechanisms of anti-inflammatory effects and glucocorticoid resistance." Journal of Complementary and Integrative Medicine 12, no. 1 (2015): 1–13. http://dx.doi.org/10.1515/jcim-2014-0051.

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AbstractGlucocorticoids (GC) are universally accepted agents for the treatment of anti-inflammatory and immunosuppressive disorders. They are used in the treatment of rheumatic diseases and various inflammatory diseases such as allergy, asthma and sepsis. They bind with GC receptor (GR) and form GC–GR complex with the receptor and exert their actions. On activation the GC–GR complex up-regulates the expression of nucleus anti-inflammatory proteins called as transactivation and down-regulates the expression of cytoplasmic pro-inflammatory proteins called as transrepression. It has been observed

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Marcocci, Claudio, Torquil Watt, Maria Antonietta Altea, et al. "Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association." European Journal of Endocrinology 166, no. 2 (2012): 247–53. http://dx.doi.org/10.1530/eje-11-0779.

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ObjectiveThe objective of this study was to investigate the side effects of glucocorticoid (GC) therapy observed by European thyroidologists during the treatment of Graves' orbitopathy (GO).DesignA questionnaire-based survey among members of the European Thyroid Association (ETA) who treat GO.ResultsA response was obtained from 128 ETA members of which 115 used GC therapy for GO. The majority of respondents (83/115, 72%) used intravenous (i.v.) GC, with a relatively wide variety of therapeutic regimens. The cumulative dose of methylprednisolone ranged between 0.5 and 12 g (median 4.5 g) for i.

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Hübner, Sabine, and Jan Tuckermann. "Molecular mechanisms of the glucocorticoid receptor in steroid therapy – lessons from transgenic mice." BioMolecular Concepts 3, no. 3 (2012): 241–53. http://dx.doi.org/10.1515/bmc-2011-0033.

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AbstractGlucocorticoids (GCs) are potent anti-inflammatory agents that are used to treat chronic inflammatory diseases, allergic conditions, and some cancers. However, their therapeutic effects are hampered by severe side effects, such as muscle weakness, insulin resistance, fat redistribution, and osteoporosis. GCs act on many cell types that express the GC receptor (GR) via several modes of action. One of them includes GR homodimers recognizing binding sequences in the DNA of gene promoters. Another mode involves the modulation of other DNA-bound transcription factors via dimer-independent m

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Li, Jia Xu, та Carolyn L. Cummins. "Disruption of Adipose Tissue Metabolism by Glucocorticoids Is Attenuated With LXRβ Antagonism". Journal of the Endocrine Society 5, Supplement_1 (2021): A821—A822. http://dx.doi.org/10.1210/jendso/bvab048.1674.

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Abstract Excessive exposure to glucocorticoids (GCs), either from endogenous overproduction of cortisol, or exogenous pharmacological GC treatment, potentiates the development of diabetes and obesity in a fat depot-specific manner. Undesirable metabolic side effects resulting from the activation of the glucocorticoid receptor (GR) remain a key limitation to the long-term therapeutic use of GCs as immunosuppressants. GC treatment disrupts the thermogenic function of brown adipose tissue (BAT) and enhances futile cycling within white adipose tissue (WAT). Mice lacking the liver X receptors (LXRs

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Qin, Kunming, Lijuan Zheng, Hao Cai, et al. "Characterization of Chemical Composition of Pericarpium Citri Reticulatae Volatile Oil by Comprehensive Two-Dimensional Gas Chromatography with High-Resolution Time-of-Flight Mass Spectrometry." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/237541.

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Pericarpium Citri Reticulatae (Chenpi in Chinese) has been widely used as an herbal medicine in Korea, China, and Japan. Chenpi extracts are used to treat indigestion and inflammatory syndromes of the respiratory tract such as bronchitis and asthma. This thesis will analyze chemical compositions of Chenpi volatile oil, which was performed by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS). One hundred and sixty-seven components were tentatively identified, and terpene compounds are the main components of Chenpi volatile

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Urasaki, Yasuyo, and Thuc T. Le. "Differentiation of Essential Oils Using Nanofluidic Protein Post-Translational Modification Profiling." Molecules 24, no. 13 (2019): 2383. http://dx.doi.org/10.3390/molecules24132383.

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Current methods for the authentication of essential oils focus on analyzing their chemical composition. This study describes the use of nanofluidic protein post-translational modification (PTM) profiling to differentiate essential oils by analyzing their biochemical effects. Protein PTM profiling was used to measure the effects of four essential oils, copaiba, mandarin, Melissa, and turmeric, on the phosphorylation of MEK1, MEK2, and ERK1/2 in the MAPK signaling pathway; Akt and 4EBP1 in the pI3K/Akt/mTOR signaling pathway; and STAT3 in the JAK/STAT signaling pathway in cultured HepG2 cells. T

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Dissertations / Theses on the topic "GC side-effects"

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Kaiser, Tina Katarina. "Treatment of acute Graft-versus-Host Disease using inorganic-organic hybrid nanoparticles." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-12C0-D.

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Books on the topic "GC side-effects"

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Dasgupta, Bhaskar. Polymyalgia rheumatica. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0134.

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This chapter reviews advances in pathogenesis; European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria with clinical, laboratory, and ultrasound criteria for classification as polymyalgia rheumatica (PMR); the heterogeneity and overlap between PMR, inflammatory arthritis, and large-vessel vasculitis as illustrated by representative cases; recent guidelines on early and correct recognition, investigations, and management of PMR; the scope of disease-modifying agents; socio-economic impact, outcomes, and patient experience in PMR. It also discusses

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Book chapters on the topic "GC side-effects"

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Renan Vieira da Costa Júnior, José, and Sérgio Luchini Batista. "Glucocorticoid-Induced Osteoporosis." In Osteoporosis - Recent Advances, New Perspectives and Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97416.

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The use of glucocorticoids (GC) in the medium and long term, causes several considerable side effects, being one of the main ones the reduction of bone mineral density (BMD). Prolonged corticosteroid therapy reduces BMD by up to 20% in trabecular bone and approximately 2–3% in cortical bone in the first year of use. This loss rate declines and stabilizes at approximately 2% in subsequent years. Therefore, there is a considerable increase in the incidence of pathological fractures, whether clinically symptomatic or asymptomatic (detected as a radiological finding), which varies between 30 and 50% of patients who use GC for more than three months. In view of the above, it is essential to prevent fractures and treat osteoporosis in patients using glucocorticoids for long periods (in particular, greater than or equal to 3 months), which may or may not be associated with clinical risk factors or previous fractures. The guidelines for the treatment and prevention of this comorbidity are well established for postmenopausal women and men over 50 years of age. However, for patients below this range, studies are still lacking.

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