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Journal articles on the topic 'GDIZ'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

ADJAKPA, Tchékpo Théodore. "EFFETS SOCIO-ECONOMIQUES ET ENVIRONNEMENTAUX DE LA CONSTRUCTION DE LA ZONE INDUSTRIELLE DE GLO-DJIGBE (GDIZ) DANS LES COMMUNES RURALES DE ZE ET DE TORI- BOSSITO." Journal de Géographie Rurale Appliquée et Développement (J_GRAD) 5, no. 2 (2025): 63–77. https://doi.org/10.5281/zenodo.14673351.

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La construction de la Zone Industrielle de Glo-Djigbé (GDIZ) affecte les conditions de vie des populations des Communes deZè et de Tori-Bossito. La présente recherche vise à étudier les effets socio-économiques et environnementaux de l’industrieinstallée. L’approche méthodologique utilisée repose sur la recherche documentaire et les enquêtes de terrain dans le milieud’étude. Il s’en est suivi le traitement des données et l’analyse des résultats à travers le modè

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2

Mosaddeghzadeh, Niloufar, Neda S. Kazemein Jasemi, Jisca Majolée, et al. "Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions." International Journal of Molecular Sciences 22, no. 22 (2021): 12493. http://dx.doi.org/10.3390/ijms222212493.

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Three decades of research have documented the spatiotemporal dynamics of RHO family GTPase membrane extraction regulated by guanine nucleotide dissociation inhibitors (GDIs), but the interplay of the kinetic mechanism and structural specificity of these interactions is as yet unresolved. To address this, we reconstituted the GDI-controlled spatial segregation of geranylgeranylated RHO protein RAC1 in vitro. Various biochemical and biophysical measurements provided unprecedented mechanistic details for GDI function with respect to RHO protein dynamics. We determined that membrane extraction of

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3

Wang, Haifeng, and Tieqiao Wen. "Modulation of Rab GDP-Dissociation Inhibitor Trafficking and Expression by the Transmembrane Protein 59 (TMEM59)." Separations 9, no. 11 (2022): 341. http://dx.doi.org/10.3390/separations9110341.

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Transmembrane protein 59 (TMEM59) is a type I transmembrane protein. However, the characterization and functions of TMEM59 in cells are not clear. Our results showed that TMEM59 localizes to vesicular structures. Further co-localization studies illustrated that TMEM59 is mainly distributed in the lysosome and acidic vesicular. TMEM59 movement between the nucleus and cell membrane was observed in living cells expressing TMEM59–EGFP fusion proteins. In addition, cell surface transport of amyloid precursor protein (APP) was significantly inhibited by TMEM59 and increased APP levels in HEK296T cel

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4

Chen, Yu, Yongqiang Deng, Jinzhong Zhang, Lu Yang, Xiangyang Xie, and Tao Xu. "GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation." Biochemical Journal 422, no. 2 (2009): 229–35. http://dx.doi.org/10.1042/bj20090624.

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Insulin stimulates GLUT4 (glucose transporter 4) translocation in adipocytes and muscles. An emerging picture is that Rab10 could bridge the gap between the insulin signalling cascade and GLUT4 translocation in adipocytes. In the present study, two potential effectors of Rab10, GDI (guanine-nucleotide-dissociation inhibitor)-1 and GDI-2, are characterized in respect to their roles in insulin-stimulated GLUT4 translocation. It is shown that both GDI-1 and GDI-2 exhibit similar distribution to GLUT4 and Rab10 at the TGN (trans-Golgi network) and periphery structures. Meanwhile, GDI-1 clearly int

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Martínez-Santiago, Oscar, Yovani Marrero-Ponce, Ricardo Vivas-Reyes, et al. "Higher-Order and Mixed Discrete Derivatives such as a Novel Graph- Theoretical Invariant for Generating New Molecular Descriptors." Current Topics in Medicinal Chemistry 19, no. 11 (2019): 944–56. http://dx.doi.org/10.2174/1568026619666190510093651.

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Background: Recently, some authors have defined new molecular descriptors (MDs) based on the use of the Graph Discrete Derivative, known as Graph Derivative Indices (GDI). This new approach about discrete derivatives over various elements from a graph takes as outset the formation of subgraphs. Previously, these definitions were extended into the chemical context (N-tuples) and interpreted in structural/physicalchemical terms as well as applied into the description of several endpoints, with good results. Objective: A generalization of GDIs using the definitions of Higher Order and Mixed Deriv

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Qiao, Jing, Oksana Holian, Bao-Shiang Lee, Fei Huang, Jihang Zhang, and Hazel Lum. "Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA." American Journal of Physiology-Cell Physiology 295, no. 5 (2008): C1161—C1168. http://dx.doi.org/10.1152/ajpcell.00139.2008.

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The cAMP-PKA cascade is a recognized signaling pathway important in inhibition of inflammatory injury events such as endothelial permeability and leucocyte trafficking, and a critical target of regulation is believed to be inhibition of Rho proteins. Here, we hypothesize that PKA directly phosphorylates GTP dissociation inhibitor (GDI) to negatively regulate Rho activity. Amino acid analysis of GDIα showed two potential protein kinase A (PKA) phosphorylation motifs, Ser174 and Thr182. Using in vitro kinase assay and mass spectrometry, we found that the purified PKA catalytic subunit phosphoryl

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7

Panarelli, Joseph F., and Anna T. Do. "Bleb Management Following Trabeculectomy and Glaucoma Drainage Device Implantation." US Ophthalmic Review 16, no. 2 (2022): 76. http://dx.doi.org/10.17925/usor.2022.16.2.76.

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While treatment options available to patients with glaucoma are expanding, trabeculectomy and glaucoma drainage device implantation (GDI) remain a mainstay in glaucoma surgical care. This article reviews key aspects of bleb management following trabeculectomy and GDI surgery. Basics of postoperative management of trabeculectomy and GDIs are reviewed, as well as how to manage complications such as early and late bleb leaks, fibrosis, bleb dysesthesia and the hypertensive phase. In general, careful surgical technique, close postoperative monitoring and appropriate intervention can help patients

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8

Robins, Richard, Cindy Baldwin, Lamine Aoudjit, Indra R. Gupta та Tomoko Takano. "Loss of Rho-GDIα sensitizes podocytes to lipopolysaccharide-mediated injury". American Journal of Physiology-Renal Physiology 308, № 11 (2015): F1207—F1216. http://dx.doi.org/10.1152/ajprenal.00225.2014.

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Nephrotic syndrome is a disease of glomerular permselectivity that can arise as a consequence of heritable or acquired changes to the integrity of the glomerular filtration barrier. We recently reported two siblings with heritable nephrotic syndrome caused by a loss of function mutation in the gene ARHGDIA, which encodes for Rho guanine nucleotide dissociation inhibitor-α (GDIα). GDIs are known to negatively regulate Rho-GTPase signaling. We hypothesized that loss of GDIα sensitizes podocytes to external injury via hyperactivation of Rho-GTPases and p38 MAPK. We examined the response of cultur

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9

Soldati, T., M. A. Riederer, and S. R. Pfeffer. "Rab GDI: a solubilizing and recycling factor for rab9 protein." Molecular Biology of the Cell 4, no. 4 (1993): 425–34. http://dx.doi.org/10.1091/mbc.4.4.425.

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Rab proteins are thought to function in the processes by which transport vesicles identify and/or fuse with their respective target membranes. The bulk of these proteins are membrane associated, but a measurable fraction can be found in the cytosol. The cytosolic forms of rab3A, rab11, and Sec4 occur as equimolar complexes with a class of proteins termed "GDIs," or "GDP dissociation inhibitors." We show here that the cytosolic form of rab9, a protein required for transport between late endosomes and the trans Golgi network, also occurs as a complex with a GDI-like protein, with an apparent mas

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10

Ranganath, Akshatha, and Adnan Hashim. "Late-Onset Endophthalmitis Secondary to Exposed Glaucoma Tube Implant in a Rare Case of Paediatric Glaucoma." Case Reports in Ophthalmological Medicine 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/183647.

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Glaucoma drainage implants (GDIs) are used to treat paediatric glaucoma resistant to conventional medical and surgical treatment, achieving good intraocular pressure (IOP) control and long-term success. Late endophthalmitis is a rare complication that may develop following GDI surgery. A 17-year-old male presented with acute endophthalmitis 2 years after Ahmed glaucoma valve implantation with pericardial patch graft for management of refractory glaucoma secondary to congenital ectropion uveae. The glaucoma tube was exposed due to erosion of the overlying conjunctiva with no visible pericardial

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KIMPLE, Randall J., Francis S. WILLARD, Melinda D. HAINS, Miller B. JONES, Gift K. NWEKE, and David P. SIDEROVSKI. "Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif." Biochemical Journal 378, no. 3 (2004): 801–8. http://dx.doi.org/10.1042/bj20031686.

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GoLoco (‘Gαi/o–Loco’ interaction) motif proteins have recently been identified as novel GDIs (guanine nucleotide dissociation inhibitors) for heterotrimeric G-protein α subunits. G18 is a member of the mammalian GoLoco-motif gene family and was uncovered by analyses of human and mouse genomes for anonymous open-reading frames. The encoded G18 polypeptide is predicted to contain three 19-amino-acid GoLoco motifs, which have been shown in other proteins to bind Gα subunits and inhibit spontaneous nucleotide release. However, the G18 protein has thus far not been characterized biochemically. Here

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12

Ferland, Russell J., Xiaoyu Li, Janet E. Buhlmann, Xia Bu, Christopher A. Walsh та Bing Lim. "Characterization of Rho-GDIγ and Rho-GDIα mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIγ". Brain Research 1054, № 1 (2005): 9–21. http://dx.doi.org/10.1016/j.brainres.2005.04.088.

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13

Cherfils, Jacqueline, and Mahel Zeghouf. "Regulation of Small GTPases by GEFs, GAPs, and GDIs." Physiological Reviews 93, no. 1 (2013): 269–309. http://dx.doi.org/10.1152/physrev.00003.2012.

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Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate dissociation of the tightly bound GDP, and turned off by GAPs, which accelerate the intrinsically sluggish hydrolysis of GTP. For Ras, Rho, and Rab GTPases, this switch incorporates a membrane/cytosol alternation regulated by GDIs and GDI-like proteins. The structures and core mechanisms of representative members of small GTPase regulators from most families have now been elucidated, illuminating their general traits combi

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14

Tiedje, Christopher, Imme Sakwa, Ursula Just, and Thomas Höfken. "The Rho GDI Rdi1 Regulates Rho GTPases by Distinct Mechanisms." Molecular Biology of the Cell 19, no. 7 (2008): 2885–96. http://dx.doi.org/10.1091/mbc.e07-11-1152.

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The small guanosine triphosphate (GTP)-binding proteins of the Rho family are implicated in various cell functions, including establishment and maintenance of cell polarity. Activity of Rho guanosine triphosphatases (GTPases) is not only regulated by guanine nucleotide exchange factors and GTPase-activating proteins but also by guanine nucleotide dissociation inhibitors (GDIs). These proteins have the ability to extract Rho proteins from membranes and keep them in an inactive cytosolic complex. Here, we show that Rdi1, the sole Rho GDI of the yeast Saccharomyces cerevisiae, contributes to pseu

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15

Sri Gyan, Deepankar, Danny Mannix, Dina Carbone, et al. "Low-temperature nanoscale heat transport in a gadolinium iron garnet heterostructure probed by ultrafast x-ray diffraction." Structural Dynamics 9, no. 4 (2022): 045101. http://dx.doi.org/10.1063/4.0000154.

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Time-resolved x-ray diffraction has been used to measure the low-temperature thermal transport properties of a Pt/Gd3Fe5O12//Gd3Ga5O12 metal/oxide heterostructure relevant to applications in spin caloritronics. A pulsed femtosecond optical signal produces a rapid temperature rise in the Pt layer, followed by heat transport into the Gd3Fe5O12 (GdIG) thin film and the Gd3Ga5O12 (GGG) substrate. The time dependence of x-ray diffraction from the GdIG layer was tracked using an accelerator-based femtosecond x-ray source. The ultrafast diffraction measurements probed the intensity of the GdIG (1 −1

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16

Nie, Jia, Chao Sun, Zhijie Chang, Nicolas Musi та Yuguang Shi. "SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells". Endocrinology 159, № 8 (2018): 3036–47. http://dx.doi.org/10.1210/en.2017-03243.

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Abstract Rho GDP-dissociation inhibitor (GDIα) inhibits glucose-stimulated insulin secretion (GSIS) in part by locking Rho GTPases in an inactive GDP-bound form. The onset of GSIS causes phosphorylation of GDIα at Ser174, a critical inhibitory site for GDIα, leading to the release of Rho GTPases and their subsequent activation. However, the kinase regulator(s) that catalyzes the phosphorylation of GDIα in islet β cells remains elusive. We propose that SAD-A, a member of AMP-activated protein kinase–related kinases that promotes GSIS as an effector kinase for incretin signaling, interacts with

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17

Wang, Shengchao, Guiqiang Qi, Zhichen Zhang, et al. "cRGD-Conjugated GdIO Nanoclusters for the Theranostics of Pancreatic Cancer through the Combination of T1–T2 Dual-Modal MRI and DTX Delivery." Molecules 28, no. 16 (2023): 6134. http://dx.doi.org/10.3390/molecules28166134.

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Clinically, magnetic resonance imaging (MRI) often uses contrast agents (CAs) to improve image contrast, but single-signal MRI CAs are often susceptible to calcification, hemorrhage, and magnetic sensitivity. Herein, iron acetylacetone and gadolinium acetylacetone were used as raw materials to synthesize a T1–T2 dual-mode imaging gadolinium-doped iron oxide (GdIO) nanocluster. Moreover, to endow the nanoclusters with targeting properties and achieve antitumor effects, the cyclic Arg-Gly-Asp (cRGD) peptide and docetaxel (DTX) were attached to the nanocluster surface, and the efficacy of the dec

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18

Weizhen Wu, Jin Shang, Yue Feng та ін. "Identification of Glucose-Dependent Insulin Secretion Targets in Pancreatic β Cells by Combining Defined-Mechanism Compound Library Screening and siRNA Gene Silencing". Journal of Biomolecular Screening 13, № 2 (2008): 128–34. http://dx.doi.org/10.1177/1087057107313763.

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Identification and validation of novel drug targets continues to be a major bottleneck in drug development, particularly for polygenic complex diseases such as type 2 diabetes. Here, the authors describe an approach that allows researchers to rapidly identify and validate potential drug targets by combining chemical tools and RNA interference technology. As a proof-of-concept study, the known mechanism Sigma LOPAC library was used to screen for glucose-dependent insulin secretion (GDIS) in INS-1 832/13 cells. In addition to several mechanisms that are known to regulate GDIS (such as cyclic ade

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19

Kibirige, Israel, and Rebecca Mampageti Maake. "The effect of guided discovery instructional strategy on grade nine learners' performance in chemical reactions in Mankweng circuit, South Africa." Journal of Technology and Science Education 11, no. 2 (2021): 569. http://dx.doi.org/10.3926/jotse.1295.

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Teaching strategies play a vital role in improving learners’ performance. This study investigated the effect of Guided Discovery Instructional Strategy (GDIS) on Grade nine learners’ performance in chemical reactions and determined the effect of GDIS on gender. A quasi-experimental design was used with a sample comprised 75 Grade nine learners purposively selected from two schools in Mankweng Circuit based on Grade 12 poor performances. Learners were randomly assigned to the Experimental Group (EG) (N = 40) and Control Group (CG) (N = 35) taught for two weeks using GDIS for EG, and Talk and Ch

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20

Shisheva, A., T. C. Südhof, and M. P. Czech. "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle." Molecular and Cellular Biology 14, no. 5 (1994): 3459–68. http://dx.doi.org/10.1128/mcb.14.5.3459-3468.1994.

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Cellular mechanisms for controlling membrane trafficking appear to involve small GTP-binding proteins such as the Rab proteins. Rab function is regulated by GDP dissociation inhibitor (GDI), which releases Rab proteins from membranes and inhibits GDP dissociation. Here we report the isolation of a full-length cDNA encoding a novel GDI isoform of 445 amino acids (GDI-2) with a deduced molecular weight of 50,649 from mouse skeletal muscle. Full-length and partial cDNA clones encoding a previously reported GDI protein (GDI-1) were also isolated from cDNA libraries prepared from rat brain and mous

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Shisheva, A., T. C. Südhof, and M. P. Czech. "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle." Molecular and Cellular Biology 14, no. 5 (1994): 3459–68. http://dx.doi.org/10.1128/mcb.14.5.3459.

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Cellular mechanisms for controlling membrane trafficking appear to involve small GTP-binding proteins such as the Rab proteins. Rab function is regulated by GDP dissociation inhibitor (GDI), which releases Rab proteins from membranes and inhibits GDP dissociation. Here we report the isolation of a full-length cDNA encoding a novel GDI isoform of 445 amino acids (GDI-2) with a deduced molecular weight of 50,649 from mouse skeletal muscle. Full-length and partial cDNA clones encoding a previously reported GDI protein (GDI-1) were also isolated from cDNA libraries prepared from rat brain and mous

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Kageyama, Yuya, and Yohei Sawada. "Global assessment of subnational drought impact based on the Geocoded Disasters dataset and land reanalysis." Hydrology and Earth System Sciences 26, no. 18 (2022): 4707–20. http://dx.doi.org/10.5194/hess-26-4707-2022.

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Abstract. Despite the importance of a link between hydrometeorological drought hazards and their socioeconomic impact, the link at a subnational level has yet to be evaluated due to the lack of precise subnational information on disaster locations. Using the newly developed Geocoded Disasters (GDIS) dataset, we examined whether the subnational socioeconomic drought impact information in GDIS could be represented by hydrometeorological hazards quantified from soil moisture in ERA5-Land during 1964–2018. We found that the socioeconomic drought impacts shown in GDIS were generally represented by

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23

Xie, Zhijuan, Xiaozhen Lv, Yongdong Hu, et al. "Development and validation of the geriatric depression inventory in Chinese culture." International Psychogeriatrics 27, no. 9 (2015): 1505–11. http://dx.doi.org/10.1017/s1041610215000162.

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ABSTRACTBackground:Depression among older adults is under-recognized either in the community or in general hospitals in Chinese culture. This study aimed to develop a culturally appropriate screening instrument for late-life depression in the non-psychiatric settings and to test its reliability and validity for a diagnosis of depression.Methods:Using a Delphi method, we developed a geriatric depression inventory (GDI), consisting of 12 core symptoms of depressive disorder in old age. We investigated its reliability and validity on 89 patients with late-life depression and 249 non-depression co

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Aydın, Canan Gönen, Hanife Hale Hekim, Hanifi Üçpunar, Dilek Öztaş, and Avni İlhan Bayhan. "Three dimensional gait analyses in dizygotic twin athletes." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 235, no. 8 (2021): 907–12. http://dx.doi.org/10.1177/09544119211012495.

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Gait analysis and gait indices are frequently used to evaluate gait pathologies and outcomes. The aim of this study is to investigate the differences in gait parameters of dizygotic twin athletes according to each other and athletes group who are similar age but non-twin. Eighty-four athletes without any disease that could cause gait pathology were included the study. Time-distance measurements, kinematic – kinetic variables, and gait deviation index (GDI) of the gait functions of twin athletes (17 boys and 25 girls, height: 153.9 ± 15 cm, weight: 45.9 ± 12 kg, leg length 80.5 ± 11 cm) were co

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Knezevic, Nebojsa, Arun Roy, Barbara Timblin, et al. "GDI-1 Phosphorylation Switch at Serine 96 Induces RhoA Activation and Increased Endothelial Permeability." Molecular and Cellular Biology 27, no. 18 (2007): 6323–33. http://dx.doi.org/10.1128/mcb.00523-07.

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ABSTRACT We identified the GDI-1-regulated mechanism of RhoA activation from the Rho-GDI-1 complex and its role in mediating increased endothelial permeability. Thrombin stimulation failed to induce RhoA activation and actin stress fiber formation in human pulmonary arterial endothelial cells transduced with full-length GDI-1. Expression of a GDI-1 mutant form (C-GDI) containing the C terminus (aa 69 to 204) also prevented RhoA activation, whereas further deletions failed to alter RhoA activation. We observed that protein kinase Cα-mediated phosphorylation of the C terminus of GDI-1 at Ser96 r

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Groysman, Maya, Idit Hornstein, Andres Alcover, and Shulamit Katzav. "Vav1 and Ly-GDI Two Regulators of Rho GTPases, Function Cooperatively as Signal Transducers in T Cell Antigen Receptor-induced Pathways." Journal of Biological Chemistry 277, no. 51 (2002): 50121–30. http://dx.doi.org/10.1074/jbc.m204299200.

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The Rho family GTPases are pivotal for T cell signaling; however, the regulation of these proteins is not fully known. One well studied regulator of Rho GTPases is Vav1; a hematopoietic cell-specific guanine nucleotide exchange factor critical for signaling in T cells, including stimulation of the nuclear factor of activated T cells (NFAT). Surprisingly, Vav1 associates with Ly-GDI, a hematopoietic cell-specific guanine nucleotide dissociation inhibitor of Rac. Here, we studied the functional significance of the interaction between Vav1 and Ly-GDI in T cells. Upon organization of the immunolog

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Lukiswati, Intan, Anik Djuraidah, and Utami Dyah Syafitri. "ANALISIS REGRESI DATA PANEL PADA INDEKS PEMBANGUNAN GENDER (IPG) JAWA TENGAH TAHUN 2011-2015." Indonesian Journal of Statistics and Its Applications 4, no. 1 (2020): 89–96. http://dx.doi.org/10.29244/ijsa.v4i1.331.

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The Gender Development Index (GDI) is a measure of the level of achievement of gender-based human development in Indonesia. Central Java Province is the largest province in Java with a GDI rate which tends to increase during the period of 2011 to 2015. Central Java's GDI, when compared to other provinces on Java Island, ranks third after DKI Jakarta and DI Yogyakarta. Central Java’s GDI consists of several observations for a certain period of time so that panel data regression analysis can be used. The purpose of this study was to model the GDI of women in Central Java with panel data regressi

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Fuentes-Alvarez, Tahimy, Pedro M. González-Jardines, José C. Fernández-Alvarez, Laura de la Torre, and Juan A. Añel. "Analysis of the Gálvez–Davison Index for the Forecasting Formation and Evolution of Convective Clouds in the Tropics: Western Cuba." Climate 11, no. 10 (2023): 209. http://dx.doi.org/10.3390/cli11100209.

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The Gálvez–Davison Index (GDI) is an atmospheric stability index recently developed to improve the prediction of thunderstorms and shallower types of moist convection in the tropics. Because of its novelty, its use for tropical regions remains largely unexplored. Cuba is a region that suffers extreme weather events, such as tropical storms and hurricanes, some of them worsened by climate change. This research analyzes the effectiveness of the GDI in detecting the potential for convective cloud development, using forecast data from the Weather Research and Forecasting (WRF) model for Western Cu

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Bilodeau, Diane, Sylvie Lamy, Richard R. Desrosiers, Denis Gingras, and Richard Béliveau. "Regulation of Rho protein binding to membranes by rhoGDI: inhibition of releasing activity by physiological ionic conditions." Biochemistry and Cell Biology 77, no. 1 (1999): 59–69. http://dx.doi.org/10.1139/o99-004.

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The Rho GDP dissociation inhibitor (GDI) is an ubiquitously expressed regulatory protein involved in the cycling of Rho proteins between membrane-bound and soluble forms. Here, we characterized the Rho solubilization activity of a glutathione S-transferase (GST) - GDI fusion protein in a cell-free system derived from rat kidney. Addition of GST-GDI to kidney brush border membranes resulted in the specific release of Cdc42 and RhoA from the membranes, while RhoB and Ras were not extracted. The release of Cdc42 and RhoA by GST-GDI was dose dependent and saturable with about 50% of both RhoA and

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EGUAVOEN, Imuetinyan, Isaac UKARIN, and Ojuye Thomas ENEWEROME. "Board Attributes and Tax Planning of Corporate Organisations in Nigeria." MANAGEMENT AND ECONOMICS REVIEW 8, no. 1 (2023): 46–57. http://dx.doi.org/10.24818/mer/2023.02-04.

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This study investigated board attributes and tax planning of corporate organisations in Nigeria. Different variables of board attributes (board independence BIND)), board size (BSIZ), and gender diversity (GDIV) were critically analysed so as to establish their relationship with tax planning (TAXP). For the aim of this very paper to be accomplished, eighty-five (85) non-financial companies that are found to be quoted on Nigerian Stock Exchange (NSE) were cautiously picked and carefully analyzed for the particular period of 2016 to 2020. Panel least squares regression was used with the help of

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Gong, Ming Cui, Isabelle Gorenne, Paul Read, et al. "Regulation by GDI of RhoA/Rho-kinase-induced Ca2+sensitization of smooth muscle myosin II." American Journal of Physiology-Cell Physiology 281, no. 1 (2001): C257—C269. http://dx.doi.org/10.1152/ajpcell.2001.281.1.c257.

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We characterized the role of guanine nucleotide dissociation inhibitor (GDI) in RhoA/Rho-kinase-mediated Ca2+ sensitization of smooth muscle. Endogenous contents (∼2–4 μM) of RhoA and RhoGDI were near stoichiometric, whereas a supraphysiological GDI concentration was required to relax Ca2+ sensitization of force by GTP and guanosine 5′- O-(3-thiotriphosphate) (GTPγS). GDI also inhibited Ca2+ sensitization by GTP · G14V RhoA, by α-adrenergic and muscarinic agonists, and extracted RhoA from membranes. GTPγS translocated Rho-kinase to a Triton X-114-extractable membrane fraction. GTP · G14V RhoA

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Claver, Alexander. "The Dutch “Digi Commissioner” (2014-2018)." Halduskultuur 21, no. 2 (2021): 4–22. http://dx.doi.org/10.32994/hk.v21i2.245.

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The Dutch governmental digital infrastructure (Generic Digital Infrastructure; GDI) is a vital element of state functioning. This article investigates the governance of the GDI as exemplified by the activities of the Digi Commissioner (officially the ‘National Coordinator Digital Government’). In 2014 the Digi Commissioner was made responsible for coordinating and re-structuring GDI-governance. Early 2018 his tasks were transferred to the Ministry of Interior Affairs. Some progress was made, but according to the Digi Commissioner himself the GDI still leaves much to be desired and is far from

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Dix, Guus. "Op weg naar prestatiebeloning in het onderwijs." Sociologie 10, no. 3 (2014): 283–300. http://dx.doi.org/10.5117/soc2014.3.gdix.

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Vasconcelos, Francisco Jose Mendes, Brenna Kelly Silva de Oliveira, Ana Paula Maria Araújo Gomes, et al. "Direito Penal na Sociedade de Risco: uma análise da expansão da tutela penal em face do paradigma penal clássico." Global Dialogue 6, no. 2 (2023): 16–35. http://dx.doi.org/10.53660/gdia.125.203.

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Este trabalho científico tem como escopo realizar uma análise crítica sobre os impactos e repercussões da nova configuração social no âmbito do Direito Penal, e sua necessária a adequação para solucionar desafios trazidos pela Sociedade do Risco em face do Paradigma Penal Clássico. Tem-se como objetivo suscitar a discussão acadêmica da moldagem do Direito Penal às necessidades modernas da Sociedade do Risco frente às situações desafiadoras insurgentes com as relações humanas em constante mudança. Aplicou-se como metodologia a pesquisa teórica-bibliográfica, baseada nos trabalhos e obras do soc

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Santiago, Giselle Feliz, and Olavo Bilac Quaresma de Oliveira Filho. "O direito das pessoas com deficiência, o meio ambiente e o contexto da sociedade de risco." Global Dialogue 6, no. 2 (2023): 1–15. http://dx.doi.org/10.53660/gdia.132.208.

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O objetivo central deste artigo é relacionar a ideia de sociedade de risco (desenvolvida pelo sociólogo Ulrich Beck), o Direito Ambiental presente na Constituição brasileira de 1988 (a partir de trabalhos de José Rubens Morato Leite e Patryck de Araujo Ayala) e a segurança alimentar de pessoas com deficiência. O artigo, através de revisão bibliográfica, se apropria dos conceitos desenvolvidos pelos autores acima citados, e opta pela montagem de um quadro teórico que situa as pessoas com deficiência no contexto da sociedade de risco. Além de contribuir com o debate acerca do lugar do grupo das

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Santiago, Giselle Feliz, and Olavo Bilac Quaresma de Oliveira Filho. "Da Lei nº 11.340/2006 a Lei nº 13.836/2019: um breve panorama sobre o processo de criminalização da violência doméstica contra mulher no Brasil." Global Dialogue 6, no. 2 (2023): 131–47. http://dx.doi.org/10.53660/gdia.131.207.

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O presente artigo tem como objetivo discutir brevemente o panorama sobre o processo de criminalização da violência doméstica contra mulher no Brasil, a partir de um quadro evolutivo que vai da publicação da Lei Maria da Penha (nº 11.340/2006) até a Lei nº 13.836/2019, que se tornou obrigatório informar sobre a condição de deficiência da vítima nos boletins de ocorrência nos casos de violência doméstica. Tratou-se de uma pesquisa bibliográfica, de natureza qualitativa, a partir do acesso a informações inerentes ao tema “Violência doméstica contra mulher” e documentos jurídicos sobre a Lei nº 11

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Zogahib, André Luiz Nunes, and João Victor Tayah Lima. "Omissão da União na contenção do garimpo ilegal: análise da responsabilidade civil pelos danos à saúde das populações amazônicas." Global Dialogue 6, no. 2 (2023): 64–87. http://dx.doi.org/10.53660/gdia.127.204.

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A presente pesquisa tem como objetivo geral analisar as políticas minerais implementadas durante o governo Jair Bolsonaro para a Amazônia Legal, correlacionando estas políticas aos danos sociais gerados à segurança alimentar das populações amazônicas e traçando um panorama jurídico da responsabilidade estatal da União por estes danos. Delineou-se uma pesquisa explicativa, utilizando-se, para tanto, das fontes documental e bibliográfica, com assento em discussões firmadas pela doutrina e jurisprudência pátrias. Utilizou-se o método dedutivo para demonstrar, em cada capítulo, se todos os pressup

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Santiago, Giselle Feliz, and Olavo Bilac Quaresma de Oliveira Filho. "Direito econômico, direito do consumidor e desenho universal (pessoas com deficiência)." Global Dialogue 6, no. 2 (2023): 51–63. http://dx.doi.org/10.53660/gdia.130.205.

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A proposta deste artigo é contribuir com as discussões acerca da condição de consumidores das pessoas com deficiência e face das normas constitucionais, direito econômico e dos demais diplomas legais que lhes asseguram proteção. Partindo-se do princípio de que esse grupo, diante do mercado de consumo, é ainda mais vulnerável que os demais consumidores, trabalharemos de que modo essas pessoas são tratadas pela lei, e qual o papel dos agentes econômicos, do Estado e da sociedade na efetivação do exercício dos direitos fundamentais desse grupo em questão.

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Souza, Sarah Lima de. "Medicina e direito no aborto legal de vítimas de estupro: as barreiras para a efetivação do princípio da dignidade da pessoa humana." Global Dialogue 6, no. 2 (2023): 148–61. http://dx.doi.org/10.53660/gdia.142.212.

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Previsto no artigo 128, inciso II, do Código Penal Brasileiro de 1940 (CPB/1940), com o fim de efetivar a Dignidade da Pessoa Humana, o procedimento abortivo em razão de gravidez resultante de estupro ainda é objeto de resistência prática por parte dos profissionais da saúde e do direito. Neste sentido, o presente artigo busca responder por quais motivos estes profissionais negam a garantia do aborto às vítimas de violência sexual, objetivando identificar tais entraves de modo a subsidiar discussões para a melhor compreensão da problemática. Para tal fim, fez-se uso de pesquisa bibliográfica s

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Sena, Raylene Rodrigues de, Alice Arlinda Santos Sobral, and Évelin Staevie dos Santos. "A violência doméstica e familiar sob a lógica das Teorias Econômica e da Desorganização Social." Global Dialogue 6, no. 2 (2023): 116–30. http://dx.doi.org/10.53660/gdia.129.206.

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A abordagem da violência doméstica e familiar contra a mulher é caminho epistemológico para possíveis respostas ao aumento de violações de direitos humanos. Desta forma, este trabalho tem por objetivo integrar as Teorias Econômica e da Desorganização Social para compreensão da violência doméstica e familiar contra a mulher. Para a consecução, adotou-se uma pesquisa exploratória, por meio de levantamento bibliográfico e documental, em abordagem qualitativa de estudos relacionados às teorias de base propostas, bem como de informação prestada pelo Ministério da Saúde, visando aplicação conceitual

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Miranda, José da Cruz Bispo de, and Leudiane Oliveira de Lima. "As ciências sociais em tempos de pandemia: ataques, desafios e proposições." Global Dialogue 6, no. 2 (2023): 36–50. http://dx.doi.org/10.53660/gdia.122.201.

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O trabalho tem o objetivo de refletir sobre as Ciências Sociais e seu campo de disputa e, em seguida, elencar a efetividade de suas contribuições no campo das análises no contexto da pandemia da COVID-19. O campo científico questiona as análises e contribuições das Ciências Sociais, contudo, nos momentos de crise essa área de conhecimento conquista protagonismo, a despeito dos concorrentes. A partir de uma revisão de literatura, o trabalho responde sobre a relevância das Ciências Sociais no campo acadêmico e, ainda, aponta, em meio à pandemia, alternativas de sociabilidades e campo político. P

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Cambi, Eduardo, Adilto Luiz Dall Oglio Junior, and André Del Grossi Assumpção. "Legitimação democrática da Corte Interamericana de Direitos Humanos." Global Dialogue 6, no. 2 (2023): 88–115. http://dx.doi.org/10.53660/gdia.140.211.

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Na América Latina, o contexto neoconstitucionalista implica inexorável revisão das fontes de cognição do Direito para refundação das bases de sustentação da pirâmide normativa. Especialmente em matéria de direitos fundamentais, abandona-se a tradicional perspectiva centrada na soberania estatal (State Approach) para afirmação internacionalizada e pluralística dos direitos humanos para além dos limites dos ordenamentos nacionais (Human Rights Approach). Nesse contexto, a atividade das Cortes Constitucionais avança pelo limiar nem sempre claro entre Direito versus Moral ou Direito versus Polític

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Ferreira, Mariana Colucci Goulart Martins, and Guilherme Coelho Colen. "A proteção do preso contra qualquer forma de sensacionalismo e a liberdade de imprensa na imagética sociedade contemporânea." Global Dialogue 6, no. 2 (2023): 162–80. http://dx.doi.org/10.53660/gdia.124.202.

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O presente artigo almeja discutir a relação existente entre os direitos às liberdades de imprensa, de informação, de pensamento e de expressão e os direitos à imagem e às integridades física e moral dos presos, somados à proteção contra qualquer forma de sensacionalismo. Isso porque, não raras vezes, as pessoas presas têm as suas imagens utilizadas sob um viés meramente sensacionalista, o que pode ocasionar uma colisão entre tais direitos, ferindo-se, inclusive, a presunção de inocência. Ressalta-se que, para melhor compreensão, estudar-se-á também o significado do termo “sensacionalismo” cons

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Bezerra Neto, Francisco das Chagas, Agílio Tomaz Marques, Mateus Ferreira de Almeida Lima, et al. "O futuro do Estado: estará o Estado Moderno em crise?" Global Dialogue 6, no. 2 (2023): 181–93. http://dx.doi.org/10.53660/gdia.133.209.

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O presente artigo discorre uma breve contextualização do referencial teórico e conceitual do futuro do Estado e a sociedade civil, referente as bases do pensamento político elaboradas desde a antiguidade grega, perpassando os pensadores e as suas respectivas formas de concepção política, que contribuíram para a análise sobre o futuro do Estado. O Estado Moderno está em crise, muitas vezes devido a ter mantido sua estrutura com elementos do primeiro liberalismo, que não se ajustaram às mudanças profundas ocorridas na sociedade. Logo, há necessidade de refletir sobre o futuro do Estado, seus des

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Bezerra Neto, Francisco das Chagas, Milena Nunes Alves de Sousa, Aline Carla De Medeiros, et al. "Direito basilar à livre iniciativa e regularização da atividade econômica." Global Dialogue 6, no. 2 (2023): 194–204. http://dx.doi.org/10.53660/gdia.134.210.

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O princípio à livre iniciativa garante o direito de averiguar as atividades econômicas sem o impacto maciço do Estado, oferecendo a população o direito de exercer a sua atividade laborativa, independentemente de sua execução, em um ambiente de livre concorrência, dentro dos limites legais e satisfeitas as exigências do bem comum. Neste contexto, através de um estudo bibliográfico e documental, com o nível de profundidade exploratória, a presente pesquisa objetiva a discussão acerca do princípio da livre concorrência na Constituição Federal de 1988 e suas singularidades aplicáveis ao Direito Ec

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Breitenbach, Fabio Gabriel, Lorena Braga d’Almeida Guedes, and Sérgio Torres Teixeira. "Introdução de um sistema de precedentes judiciais no Brasil: stare decisis brasiliensis." Global Dialogue 6, no. 1 (2023): 1–25. http://dx.doi.org/10.53660/gdia.102.104.

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Sob a perspectiva de um novo paradigma – o Código de Processo Civil de 2015 – o ordenamento normativo brasileiro clama pelo amadurecimento de uma nova sistemática na sua processualística. Assim, tem-se observado que, ao julgador, foi direcionado o dever de neutralizar as incertezas e imprecisões legislativas para melhor adequá-las aos casos concretos. No entanto, a produção jurisdicional do direito não tem acompanhado aos anseios do sistema de precedentes judiciais, de modo que a doutrina passou a protagonizar um relevante papel no direcionamento da atuação dos julgadores. O presente estudo é

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Castilho, Fábio Francisco de Almeida, and Diego dos Santos Alves. "O final do escravismo na imprensa alagoana: os abolicionistas de Maceió e a resistência proprietária em O Orbe." Global Dialogue 6, no. 1 (2023): 69–89. http://dx.doi.org/10.53660/gdia.103.105.

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Este artigo estuda dois posicionamentos rivais encontrados nas folhas que circularam em Maceió durante a década final do escravismo. De um lado, temos a argumentação favorável à libertação dos escravizados em O Lincoln e O Gutenberg, periódicos que organizaram campanha abolicionista e procuraram fomentar o final da escravidão na província alagoana, tendo como principal estratégia o incentivo para que os escravizados acionassem a justiça e obtivessem a liberdade pela via legal. Por outro lado, temos os empedernidos de O Orbe, que tentava convencer seus leitores da necessidade de manutenção da e

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Araújo, Fabio Caldas de. "O princípio da primazia do mérito no recurso especial e extraordinário." Global Dialogue 6, no. 1 (2023): 25–34. http://dx.doi.org/10.53660/gdia.106.105.

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O sistema processual passa por uma importante mudança pautada pelo repúdio ao formalismo e pela necessidade de entrega efetiva e adequada da tutela jurisdicional para aquele que confia na atividade jurisdicional e no Estado de Direito. A simples prolação de uma decisão não atende ao interesse das partes. Exige-se que esta decisão seja de mérito para que a pacificação e estabilidade das relações sociais possa ser alcançada. Este estudo examina a primazia do mérito na seara recursal e com foco voltado para os recursos de estrito direito que também permitem a sanação de vícios processuais para pr

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Wolffenbüttel, Cristina Rolim. "O ensino de música nas escolas públicas municipais do litoral do Rio Grande do Sul." Global Dialogue 6, no. 1 (2023): 54–68. http://dx.doi.org/10.53660/gdia.100.102.

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Este artigo apresenta os resultados da investigação que objetivou investigar a presença da música em escolas públicas do Conselho Regional de Desenvolvimento do Litoral do Rio Grande do Sul (COREDE Litoral/RS). A pesquisa configurou-se metodologicamente por um survey interseccional de grande porte e uma abordagem quantitativa. Para coleta dos dados foi utilizado um questionário autoadministrado que foi encaminhado para as secretarias de educação de cada município, via e-mail. Posteriormente, procedeu-se à análise do conteúdo, verificando como ocorre a inserção da música. Através da análise dos

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Aparecido Contelli, Everson, and Ilton Garcia Da Costa. "A investigação criminal e o princípio constitucional implícito da dialogicidade no enfrentamento de fenômenos criminais complexos." Global Dialogue 6, no. 1 (2023): 35–53. http://dx.doi.org/10.53660/gdia.114.111.

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A investigação criminal é um instituto normalmente compreendido de forma isolada no sistema de justiça criminal, que exige iminente e aprofundado debate científico acerca da necessária interdisciplinaridade envolvendo não apenas a instrumentalidade constitucional. Para tanto será realizado um estudo de forma transversal, que comunique com a análise empírica em busca de uma dialogicidade, decorrência da necessária conexão entre direito material, processual, por meio de pesquisa bibliográfica, teórica e documental. Como resultado dos estudos, espera-se produzir material suficiente para uma análi

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