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Dissertations / Theses on the topic 'Geant4 application for emission tomography'

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Published: 10 September 2021

Last updated: 1 February 2022

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1

Guy, Matthew John. "The application of quantitative single emission tomography." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326266.

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2

Aly, Moamen. "The application of positron emission tomography in radiotherapy treatment planning." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/the-application-of-positron-emission-tomography-in-radiotherapy-treatment-planning(23a8d56c-c6da-4e3f-a27e-6ecbc979c86e).html.

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Positron emission tomography (PET) is a molecular imaging technique that provides a direct and accurate evaluation of tissue function in vivo. PET of the glucose analogue 18F-fluoro-deoxy-glucose, is increasingly in use to aid in gross target volume delineation in radiotherapy treatment planning (RTP) where it shows reduced inter-observer variability. The aim of this thesis was to develop and investigate a new technique for delineating PET-GTV with sufficient accuracy for RTP. A new technique, volume and contrast adjusted thresholding (VCAT), has been developed to automatically determine the o

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3

Persson, Daniel. "Application of GEANT4 toolkit for simulations of high gradient phenomena." Thesis, Uppsala universitet, FREIA, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353347.

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To study electron emissions and dark currents in the accelerating structures in particle colliders, a test facility with a spectrometer has been constructed at CERN. This spectrometer has been simulated in the C++ toolkit GEANT4 and in this project the simulation has been improved to handle new realistic input data of the emitted electrons. The goal was to find relations between where the electrons are emitted inside the accelerating structure and the energy or position of the particles measured by the spectrometer. The result was that there is a linear relation between the initial position of

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4

Maguire, Ralph Paul. "Application of pharmacokinetic models to projection data in positron emission tomography." Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/844467/.

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In positron emission tomography (PET), coincidence detection of annihilation photons enables the measurement of Radon transforms of the instantaneous activity concentration of labelled tracers in the human body. Using reconstruction algorithms, spatial maps of the activity distribution can be created and analysed to reveal the pharmacokinetics of the labelled tracer. This thesis considers the possibility of applying pharmacokinetic modelling to the count rate data measured by the detectors, rather than reconstructed images, A new concept is proposed - parameter projections - Radon transforms o

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5

Cree, Michael J. "The Compton Scattering Camera in application to single photon emission computed tomography." Thesis, University of Canterbury. Electrical and Electronic Engineering, 1994. http://hdl.handle.net/10092/6756.

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A study of the Compton Scattering Camera in application to single photon emission computed tomography has been carried out and is presented in this thesis. It is shown that conventional gamma camera technology is fundamentally restricted by the collimator. The collimator places restrictions on camera sensitivity and on achievable reconstructed spatial resolution. The Compton scattering camera is proposed as an alternative to conventional gamma camera technology. The Compton scattering camera uses the process of Compton scattering to determine where a photon has come from. This results in a sig

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6

Aryal, Bijaya. "Transfer of learning with an application to the physics of positron emission tomography." Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/351.

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7

Mills, J. A. "Theory of longitudinal emission computed tomography and the practical application to cardiac imaging." Thesis, University of Warwick, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383293.

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8

Dunkley, Paul. "The investigation and application of OET (Optical Emission Tomography) as a combustion diagnostic." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403115.

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9

Link, Jeanne Meyers. "Mixed-mode chromatographic separation and whole column radiation detection to improve sensitivity in radiometabolite analysis : application to (Carbon-11)-meta-hydroxyephedrine in plasma /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8578.

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10

Yu, Haiming. "Analog ASICs for a Depth of Interaction (DOI) Positron Emission Tomography (PET) dectector module /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6066.

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11

Alaamer, Abdulaziz. "Quantification in single photon emission computed tomography and its application to targeted radiotherapy and dosimetry." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296162.

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12

Fuin, N. "Estimation of the image quality in emission tomography : application to optimization of SPECT system design." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1417803/.

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In Emission Tomography the design of the Imaging System has a great influence on the quality of the output image. Optimisation of the system design is a difficult problem due to the computational complexity and to the challenges in its mathematical formulation. In order to compare different system designs, an efficient and effective method to calculate the Image Quality is needed. In this thesis the statistical and deterministic methods for the calculation of the uncertainty in the reconstruction are presented. In the deterministic case, the Fisher Information Matrix (FIM) formalism can be emp

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13

Lau, Yiu Hon. "Application of joint intensity algorithms to the registration of emission topography and anatomical images /." Electronic version, 2004. http://adt.lib.uts.edu.au/public/adt-NTSM20040901.094913/index.html.

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14

Cluckie, Alice Jane. "Development and application of an automated analysis method for individual cerebral perfusion single photon emission tomography images." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249675.

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15

Vafaee, Manouchehr S. "Aerobic glycolysis in response to visual stimulation studied by positron emission tomography (PET) : preliminary application to mitochondrial disorders." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0018/NQ55389.pdf.

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16

Yunusa, Garba Haruna. "Assessment of the impact of the application single photon emission computerized tomography and SPECT-CT on lesion catergorization." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16777.

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Includes bibliographical references<br>Objectives: To assess initial experience with the use of a new SPECT-CT in the evaluation of lesions. Methods: The folder number, radiopharmaceutical used and type of scan of patients examined with a new Siemens T6 SPECT-CT between 2 April and 31 December 2013 were retrieved. The number of 99m Tc -MDP bone scans was sufficient for a detailed analysis. The scans were re-processed and reported by the observer before he was given any clinical information. Whole body planar, whole body planar plus SPECT and whole body planar plus SPECT-CT images were assessed

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17

Ahmadi, Ali. "Application of Collagen Matrices for Enhancing Cardiac Regeneration." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31342.

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Injectable biomaterials have emerged as a treatment for myocardial infarction (MI). They can be applied either as an enhancement for cell therapy or as a stand-alone treatment for MI. The main focus of this study was to apply circulating angiogenic cells (CACs) with or without an injectable collagen matrix for MI treatment in a mouse model. Furthermore, a collagen-chitosan matrix was tested for modulating the myocardial maladaptive remodeling post-MI. First, the in vivo thermo-gelling and retention properties of the collagen matrix were validated using positron emission tomography (PET) tracer

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18

Visser, Thomas Jakob. "Development of new muscarinic and [beta]-adrenergic receptor radiopharmaceuticals for Positron Emission Tomography application to lungs, heart and brain /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1997. http://irs.ub.rug.nl/ppn/297496689.

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19

Wilczek, Brigitte. "Application of nuclear medicine methods in patients with breast cancer /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-340-X/.

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20

Thomas, Adam J. "Characterization of cAMP-Specific Phosphodiesterase-4 (R)-[11C]Rolipram Small Animal Positron Emission Tomography and Application in a Streptozotocin-Induced Model of Hyperglycemia." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19877.

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Elevated sympathetic nervous system (SNS) tone contributes to excess cardiac mortality associated with type 2 diabetes mellitus (T2DM). Chronic SNS stimulation has detrimental effects to the heart, in particular, with its cell signaling abilities. (R)-[11C]Rolipram small animal positron emission tomography (PET), an noninvasive nuclear imaging modality, was used to assess phosphodiesterase-4 (PDE4) alterations in a high fat diet (HFD), streptozotocin (STZ) induced model of hyperglycemia in rats. Prior to investigation in the animal model, characterization of (R)-[11C]rolipram small animal PET

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21

Tadday, Klaus Alexander [Verfasser], and Hans-Christian [Akademischer Betreuer] Schultz-Coulon. "Scintillation Light Detection and Application of Silicon Photomultipliers in Imaging Calorimetry and Positron Emission Tomography / Klaus Alexander Tadday ; Betreuer: Hans-Christian Schultz-Coulon." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179783301/34.

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22

Cselényi, Zsolt. "Development, validation and application of advanced neuroimaging analysis tools for in vivo neuroreceptor studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-261-6/.

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23

Handa, Nobuhiro. "Quantitative myocardial FDG uptake by positron emission tomography in rat heart and its application for longitudinal multiple studies in progressive hypertrophy of heart model." Kyoto University, 2008. http://hdl.handle.net/2433/135924.

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24

Velikyan, Irina. "Synthesis, Characterisation and Application of 68Ga-labelled Macromolecules." Doctoral thesis, Uppsala universitet, Kemiska institutionen, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5876.

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The positron emitting radionuclide 68Ga (T1/2 = 68 min) might become of practical interest for clinical positron emission tomography (PET). The metallic cation, 68Ga(III), is suitable for complexation with chelators, either naked or conjugated with biological macromolecules. Such labelling procedures require pure and concentrated preparations of 68Ga(III), which cannot be sufficiently fulfilled by the presently available 68Ge/68Ga generator eluate. This thesis presents methods to increase the concentration and purity of 68Ga obtained from a commercial 68Ge/68Ga generator. The use of the precon

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25

Rohling, Heide. "Simulation studies for the in-vivo dose verification of particle therapy." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-175213.

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An increasing number of cancer patients is treated with proton beams or other light ion beams which allow to deliver dose precisely to the tumor. However, the depth dose distribution of these particles, which enables this precision, is sensitive to deviations from the treatment plan, as e.g. anatomical changes. Thus, to assure the quality of the treatment, a non-invasive in-vivo dose verification is highly desired. This monitoring of particle therapy relies on the detection of secondary radiation which is produced by interactions between the beam particles and the nuclei of the patient’s tissu

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26

Velikyan, Irina. "Synthesis, Characterisation and Application of ⁶⁸Ga-labelled Macromolecules." Doctoral thesis, Uppsala : Acta Universitetis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5876.

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27

Maingueneau, Clémence. "Valorisation des sultones et boratranes comme plateformes de radiomarquage au fluor-18 : application au développement de radiotraceurs pour l'imagerie de l'hypoxie par Tomographie par Emission de Positons." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC228.

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Les travaux de thèse ont porté sur le développement de deux plateformes de radiomarquage polyvalentes pour faciliter l’incorporation du fluor-18, un isotope de choix pour l’imagerie TEP (Tomographie par Emission de Positons). La première plateforme comporte une structure sultone conduisant à un [18F]fluorosulfonate par ouverture du cycle avec le [18F]fluorure. Celle-ci a été valorisée par le couplage avec des ligands 2-nitroimidazoliques pour former un agent d’imagerie TEP spécifique de l’hypoxie. Une série de dérivés caractérisés par des propriétés d’hydrophilie différentes a été synthétisée

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28

Henriques, de Figueiredo Bénédicte. "Evaluation de l’integration des donnees issues de la tomographie par emission de positons en radiotherapie : application à deux modèles cliniques : les cancers ORL et les cancers pulmonaires." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22125/document.

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Objectif : Etudier l’impact volumétrique et dosimétrique de l’intégration des données de tomographie par émission de positons (TEP) en radiothérapie (RT) à travers deux modèles cliniques : les cancers oto-rhino-laryngologiques (ORL) et les cancers pulmonaires. Matériel et méthodes : Pour les cancers ORL, après un travail préalable sur fantôme pour mise au point d’une méthode de segmentation automatique par seuillage adaptatif, deux séries de neuf et 15 patients présentant un cancer ORL traité par RT, ont bénéficié d’une TEP respectivement au 18F-Fluorodeoxyglucose (18F-FDG) et au 18F-Flu

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29

James, Damien. "Développement d'outils organométalliques en vue du transfert de méthyle, application à la synthèse de radiotraceurs pour la TEP." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13900/document.

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Le couplage de Stille modifié développé par l’équipe du Pr Fouquet a été appliqué à la méthylation de nucléosides, dinucléotides et oligonucléotides dans le but de mettre au point une méthodologie de marquage d’aptamères au carbone 11 pour le diagnostic précoce de cancer par TEP. Ce couplage pallado-catalysé est basé sur l’utilisation de monoorganoétain activé par une source de fluorure permettant d’accélérer la réaction. Dans un premier temps, les essais méthodologiques ont permis de mettre au point le transfert de groupement méthyle sur différents nucléosides et un dinucléotide modifiés dans

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30

Travere, Jean-Marcel. "Analyse automatique quantitative en tomographie par emission de positions : application a l'etude de la concentration en recepteurs muscariniques de la paroi ventriculaire gauche." Caen, 1987. http://www.theses.fr/1987CAEN2033.

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31

Jouvie, Camille. "Estimation de la fonction d’entrée en tomographie par émission de positons dynamique : application au fluorodesoxyglucose." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112303/document.

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La tomographie par émission de positons (TEP) est une méthode d’imagerie fonctionnelle, utilisée en particulier lors du développement de nouveaux médicaments et pour imager les tumeurs. En TEP, l’estimation de la concentration plasmatique artérielle d’activité du traceur non métabolisé (nommée « fonction d’entrée ») est nécessaire pour l’extraction des paramètres pharmacocinétiques. Ceux-ci permettent de quantiﬁer le comportement du traceur dans les tissus, ou plus précisément le traitement du traceur par les tissus. Cette thèse constitue une contribution à l’étude de la fonction d’entrée, par

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32

Nguyen, Pham Truong. "Imagerie corrélative : autoradiographie - tomographie par émission de positons : application à l’imagerie cérébrale dans le lupus." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAE027.

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L’imagerie nucléaire se révèle essentielle dans le domaine clinique et pré-clinique pour l’étude de la biodistribution du médicament et le suivi de l’évolution de la pathologie. La TEP (Tomographie par Émission de Positons) est aujourd’hui un standard pour l’imagerie fonctionnelle avec une sensibilité de l’ordre du picomole. Elle offre une résolution de l’ordre du millimètre. Dans le cadre de cette thèse, l’autoradiographie, avec des capteurs semi-conducteurs Mimosa-28, permet d’obtenir une résolution sub-millimètre tout en gardant une bonne sensibilité afin de mieux visualiser la distribution

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33

Irace, Zacharie. "Modélisation statistique et segmentation d'images TEP : application à l'hétérogénéité et au suivi de tumeurs." Phd thesis, Toulouse, INPT, 2014. http://oatao.univ-toulouse.fr/12201/1/irace.pdf.

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Cette thèse étudie le traitement statistique des images TEP. Plus particulièrement, la distribution binomiale négative est proposée pour modéliser l’activité d’une région mono-tissulaire. Cette représentation a l’avantage de pouvoir prendre en compte les variations d’activité biologique (ou hétérogénéité) d’un même tissu. A partir de ces résultats, il est proposé de modéliser la distribution de l’image TEP entière comme un mélange spatialement cohérent de lois binomiales négatives. Des méthodes Bayésiennes sont considérées pour la segmentation d’images TEP et l’estimation conjointe des paramèt

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34

Fall, Mame Diarra. "Modélisation stochastique de processus pharmaco-cinétiques, application à la reconstruction tomographique par émission de positrons (TEP) spatio-temporelle." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112035.

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L'objectif de ce travail est de développer de nouvelles méthodes statistiques de reconstruction d'image spatiale (3D) et spatio-temporelle (3D+t) en Tomographie par Émission de Positons (TEP). Le but est de proposer des méthodes efficaces, capables de reconstruire des images dans un contexte de faibles doses injectées tout en préservant la qualité de l'interprétation. Ainsi, nous avons abordé la reconstruction sous la forme d'un problème inverse spatial et spatio-temporel (à observations ponctuelles) dans un cadre bayésien non paramétrique. La modélisation bayésienne fournit un cadre pour la r

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35

Razifar, Pasha. "Novel Approaches for Application of Principal Component Analysis on Dynamic PET Images for Improvement of Image Quality and Clinical Diagnosis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6053.

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36

Sihver, Sven. "Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485.

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The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. The SP plates showed superior sensitivity and a linear response over a wide radioactivity range. Autoradioradiography provided reliable resu

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37

Macías, Montero José Gabriel. "VIPPIX: A readout ASIC for the next generation of human brain PET scanners." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663182.

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Positron emission tomography (PET) is a molecular imaging technique used for several decades in nuclear medicine that provides precise physiological information of the human body, what is crucial in oncology, cardiology, and neuropsychiatry. Due to physical, the best spatial resolution of PET is approximately 1 mm for human brain scanners. Unfortunately, the minimum resolution of the best commercial PET scanners for humans is 4-5 mm due to technological limitations. In this thesis, an application specific integrated circuit (ASIC) to readout the energy and the time stamp of a high-density and

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38

Lian, Chunfeng. "Information fusion and decision-making using belief functions : application to therapeutic monitoring of cancer." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2333/document.

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La radiothérapie est une des méthodes principales utilisée dans le traitement thérapeutique des tumeurs malignes. Pour améliorer son efficacité, deux problèmes essentiels doivent être soigneusement traités : la prédication fiable des résultats thérapeutiques et la segmentation précise des volumes tumoraux. La tomographie d’émission de positrons au traceur Fluoro- 18-déoxy-glucose (FDG-TEP) peut fournir de manière non invasive des informations significatives sur les activités fonctionnelles des cellules tumorales. Les objectifs de cette thèse sont de proposer: 1) des systèmes fiables pour prédi

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Lamprou, Efthymios. "Development and Performance Evaluation of High Resolution TOF-PET Detectors Suitable for Novel PET Scanners." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/162991.

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[ES] La Tomografía por Emisión de Positrones (PET) es una de las técnicas más importantes en la medicina de diagnóstico actual y la más representativa en el campo de la Imagen Molecular. Esta modalidad de imagen es capaz de producir información funcional única, que permite la visualización en detalle, cuantificación y conocimiento de una variedad de enfermedades y patologías. Áreas como la oncología, neurología o la cardiología, entre otras, se han beneficiado en gran medida de esta técnica. A pesar de que un elevado número de avances han ocurrido durante el desarrollo del PET, existen otros q

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Benoit, Didier. "Conception, reconstruction et évaluation d'une géométrie de collimation multi-focale en tomographie d'émission monophotonique préclinique." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00949951.

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La tomographie d'émission monophotonique (TEMP) dédiée au petit animal est une technique d'imagerie nucléaire qui joue un rôle important en imagerie moléculaire. Les systèmes TEMP, à l'aide de collimateurs pinholes ou multi-pinholes, peuvent atteindre des résolutions spatiales submillimétriques et une haute sensibilité pour un petit champ de vue, ce qui est particulièrement attractif pour imager des souris. Une géométrie de collimation originale a été proposée, dans le cadre d'un projet, appelé SIGAHRS, piloté par la société Biospace. Ce collimateur présente des longueurs focales qui varient s

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Monteiro, André Miguel Martins Costa Correia. "GATE Model of a SPECT-CT equipment for breast cancer diagnosis." Master's thesis, 2016. http://hdl.handle.net/10451/26323.

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Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Radiações em Diagnóstico e Terapia)Universidade de Lisboa, Faculdade de Ciências, 2016<br>Dedicated imaging systems for breast cancer imaging have been comprehensively studied over the past decade. However, since they comprise only one imaging modality these systems are only able to provide either anatomical or functional information of the object of interest. The aim of this work was to simulate and evaluate the implementation of a dedicated system that would be able to extract information regarding both systems in order to provide

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42

Agasthya, Greeshma Ananth. "Low-dose imaging of liver diseases through neutron stimulated emission computed tomography: Simulations in GEANT4." Diss., 2013. http://hdl.handle.net/10161/7121.

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<p>Neutron stimulated emission computed tomography (NSECT) is a non-invasive, tomographic imaging technique with the ability to locate and quantify elemental concentration in a tissue sample. Previous studies have shown that NSECT has the ability to differentiate between benign and malignant tissue and diagnose liver iron overload while using a neutron beam tomographic acquisition protocol followed by iterative image reconstruction. These studies have shown that moderate concentrations of iron can be detected in the liver with moderate dose levels and long scan times. However, a low-dose, redu

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Kapadia, Anuj. "Accuracy and Patient Dose in Neutron Stimulated Emission Computed Tomography for Diagnosis of Liver Iron Overload: Simulations in GEANT4." Diss., 2007. http://hdl.handle.net/10161/380.

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Neutron stimulated emission computed tomography (NSECT) is being proposed as an experimental technique to diagnose iron overload in patients. Proof-of-concept experiments have suggested that NSECT may have potential to make a non-invasive diagnosis of iron overload in a clinical system. The technique's sensitivity to high concentrations of iron combined with tomographic acquisition ability gives it a unique advantage over other competing modalities. While early experiments have demonstrated the efficacy of detecting samples with high concentrations of iron, a tomography application for patient

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Kapadia, Anuj Jawahar. "Accuracy and Patient Dose in Neutron Stimulated Emission Computed Tomography for Diagnosis of Liver Iron Overload Simulations in GEANT4." Diss., 2007. http://hdl.handle.net/10161/380.

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45

"Application of Joint Intensity Algorithms to the Registration of Emission Tomography and Anatomical Images." University of Technology, Sydney. Department of Applied Physics, 2004. http://hdl.handle.net/2100/288.

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In current practice, it is common in medical diagnosis or treatment monitoring for a patient to require multiple examinations using different imaging techniques. Magnetic resonance (MR) imaging and computed tomography (CT) are good at providing anatomical information. Three-dimensional functional information about tissues and organs is often obtained with radionuclide imaging modalities: positron emission tomography (PET) and single photon emission tomography (SPET). In nuclear medicine, such techniques must contend with poor spatial resolution, poor counting statistics of functional images an

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Ma, Kuo-Hsing, and 馬國興. "Application and evaluation of dual-isotope single photon emission tomography in non-human primates." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/01243234491396911211.

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博士<br>國防醫學院<br>生命科學研究所<br>91<br>Parkinson's disease (PD) is a degeneration of the nigrostriatal dopaminergic pathway, leading to a selective loss of dopamine in the striatum (ST). In addition to decline of dopamine, serotonergic neurons are affected by the disease process. [99mTc]TRODAT and [123I]IBZM are two imaging radioligands, respectively specific for pre- and post-synaptic dopamine binding sites. Using single-photon emission computed tomography (SPECT), [99mTc]TRODAT can demonstrate the status of dopaminergic neurons in vivo, whereas [123I]IBZM reflect the density of dopamine D2 receptor

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Hsu, Shih Chieh, and 許詩婕. "Investigation on the preparative requirements of hydroxymethyl fenbufen octyl amide for application in positron emission tomography." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/tq995p.

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Lin, Chang-Shiun, and 林昌勳. "Application of the Intraoperative Dual Photon Emission Computed Tomography System in Sentinel Lymph Node Detection: A Simulation Study." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/55283983834524927141.

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博士<br>國立清華大學<br>生醫工程與環境科學系<br>104<br>The sentinel lymph node (SLN) hypothesis is applied as part of the standard procedure for identifying early-stage breast cancer. Thus, an imaging system that can locate SLNs in operating rooms is desired. Several 2-D probe imaging systems and a freehand single-photon emission-computed tomography (fhSPECT) system have been proposed. However, 2-D probe imaging systems are affected by shine-through and shadowing effects. Here, we proposed an alternative to 3D imaging systems, i.e., a dual-photon emission computed tomography (DuPECT) system, which integrates bo

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Chuang, Yen-Chi, and 莊彥騏. "Application of machine learning methodology on the diagnosis of Parkinson''s disease with single photon emission computed tomography." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/gvn95x.

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Lu, Kuan-Pai, and 陸冠百. "Application of A Dual Photons Emission Computed Tomography (DuPECT) System in the Sentinel Lymph Node Location Detection : A Monte Carlo Simulation Study." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/49015349973724801655.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>100<br>In clinic, the detection of breast metastasis utilizes the aggregating effect of 99mTc labeled pharmaceuticals in sentinel lymph node (SLN). The doctor hold the gamma counting probe to locate the most radioactive (“hottest”) node (i.e. SLN) during operation and perform the resection. But the gamma counting probe technique is susceptible to noise and lack of depth information. In recent years, many groups devoted to develop an imaging probe suitable for the use in the operating room, hoping to overcome the drawbacks of the gamma counting probe. However, tr

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